研究者詳細 - 石川　健治

論文 - 石川　健治

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窒化物半導体プラズマエッチングにおける原子層反応制御と低ダメージプロセス招待有り査読有り

堤隆嘉，石川健治，近藤博基，関根誠，堀勝

プラズマ核融合学会誌 97 巻 ( 9 ) 頁： 517 - 521 2021年9月

先端デバイス構造を実現する超絶ドライエッチング技術の最前線はじめに招待有り査読有り

石川健治，竹田圭吾

プラズマ核融合学会誌 97 巻 ( 9 ) 頁： 508 - 510 2021年9月

Novel Method of Rebound Tailing Pulse (RTP) for Water Dissociation 査読有り

Shimizu, N; Borude, RR; Tanaka, R; Ishikawa, K; Oda, O; Hosoe, H; Ino, S; Inoue, Y; Hori, M

IEEE TRANSACTIONS ON PLASMA SCIENCE 49 巻 ( 9 ) 頁： 2893 - 2900 2021年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：IEEE Transactions on Plasma Science

Simple low-temperature pulsed power dissociation method for high resistive liquid is proposed in this article. Active high voltage rebound tailing pulse (RTP) diodes are adopted to conventional high voltage pulse power sources. In order to explain this method, the study was performed using deionized water (DIW) (high resistive >17MΩcm) electrolysis with two immersed electrodes. The forward pulses, the full-width at half-maximum (FWHM) of 400 ns and forward voltage (7 kV) with rising-up ratio (dV/dt) of 1011 V/s, were applied to the electrodes. When a 5 kV RTP diode was simply adopted to this electrical circuit and DIW load in series, the high forward voltage pulse and continuous high reverse current were applied to this circuit. Then, H2 was generated at the anode electrode and OH radical (OH) in the water vessel. Those phenomena were apparently dependent on the anode electrode area. At the beginning of the forwarded high voltage application, the circuit behaved as capacitance load with generated ions and built up charges at the interface between DIW and the electrode. Continuous rebounded high reverse voltage and highly built-up reverse recovery charges induce avalanche breakdown of RTP diode. The rebounded electrical current was found to be collected in the circuit, accompanied by the generation of hydrogen and OH, as well as the tailing current flowing at the interface as a resistive load. In consequence, we point out that rebounded electrons injected from the surrounding water to the anode electrode interface induced the water electrolysis characteristically, according to RTP-diode inserted in the circuit.

DOI： 10.1109/TPS.2021.3102639

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Scopus

酸素ラジカル照射したl-トリプトファン溶液の殺菌効果査読有り

石川健治, 堀勝, 伊藤昌文, 岩田直幸, 田中宏昌, 橋爪博司

応用物理学会学術講演会講演予稿集 2021.2 巻 ( 0 ) 頁： 1677 - 1677 2021年8月

原子層エッチングの反応素過程とその設計、制御査読有り

石川健治, Nguyen Thi-Thuy-Nga, 堤隆嘉, 蕭世男, 関根誠, 堀勝, 近藤博基

応用物理学会学術講演会講演予稿集 2021.2 巻 ( 0 ) 頁： 120 - 120 2021年8月

低温プラズマ照射した養殖餌料アルテミアの成長促進査読有り

堀勝, 山内拓海, 石川健治, 田中宏昌, 秋山真一, 橋爪博司

応用物理学会学術講演会講演予稿集 2021.2 巻 ( 0 ) 頁： 1693 - 1693 2021年8月

Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated Ringer's lactate 査読有り Open Access

Jiang, L; Zheng, H; Lyu, QY; Hayashi, S; Sato, K; Sekido, Y; Nakamura, K; Tanaka, H; Ishikawa, K; Kajiyama, H; Mizuno, M; Hori, M; Toyokuni, S

REDOX BIOLOGY 43 巻頁： 101989 2021年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Redox Biology

Non-thermal plasma (NTP), an engineered technology to generate reactive species, induces ferroptosis and/or apoptosis specifically in various-type cancer cells. NTP-activated Ringer's lactate (PAL) is another modality for cancer therapy at preclinical stage. Here we found that PAL induces selective ferroptosis of malignant mesothelioma (MM) cells, where non-targeted metabolome screening identified upregulated citrulline-nitric oxide (.NO) cycle as a PAL target .NO probe detected biphasic peaks transiently at PAL exposure with time-dependent increase, which was responsible for inducible .NO synthase (iNOS) overexpression through NF-κB activation. .NO and lipid peroxidation occupied lysosomes as a major compartment with increased TFEB expression. Not only ferrostatin-1 but inhibitors for .NO and/or iNOS could suppress this ferroptosis. PAL-induced ferroptosis accompanied autophagic process in the early phase, as demonstrated by an increase in essential amino acids, LC3B-II, p62 and LAMP1, transforming into the later phase with boosted lipid peroxidation. Therefore, .NO-mediated lysosomal impairment is central in PAL-induced ferroptosis.

DOI： 10.1016/j.redox.2021.101989

Brain cell proliferation in adult rats after irradiation with nonequilibrium atmospheric pressure plasma 査読有り Open Access

Yamato, M; Tamura, Y; Tanaka, H; Ishikawa, K; Ikehara, Y; Hori, M; Kataoka, Y

APPLIED PHYSICS EXPRESS 14 巻 ( 6 ) 頁： 067002 2021年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Applied Physics Express

Nonequilibrium atmospheric pressure plasma (NEAPP) has the potential for a wide range of medical applications, including wound healing, blood coagulation, and malignant cell apoptosis. However, its effect on the mammalian central nervous system remains unclear. We studied histological changes in the cerebral cortex of adult rats, following irradiation of the brain surface with NEAPP. NEAPP irradiation made three laminar tissue structures and induced high proliferation of brain-resident immature cells as well as bone marrow-derived cells. These observations indicate that NEAPP irradiation induced rearrangement of cellular and tissue organization, including cell proliferation in the central nervous system in vivo.

DOI： 10.35848/1882-0786/ac03c1

Open Access

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Scopus

Hydrogen peroxide in lactate solutions irradiated by non-equilibrium atmospheric pressure plasma 査読有り

Liu, Y; Ishikawa, K; Miron, C; Hashizume, H; Tanaka, H; Hori, M

PLASMA SOURCES SCIENCE & TECHNOLOGY 30 巻 ( 4 ) 2021年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Plasma Sources Science and Technology

A mechanism of hydrogen peroxide (H2O2) generation in plasma-activated lactated Ringer's solution (PAL) has been analyzed. PAL was produced by irradiating a sodium lactate solution, a class of hydroxy acid, with non-equilibrium atmospheric pressure plasma (NEAPP). The concentration of H2O2 generation was dependent on the initial lactate concentrations, which ranged from 0-28 mM. However, the generation of H2O2 was inhibited by higher lactate concentration. The formation of H2O2 is proposed by catalyzed lactate and radicals in aqueous solution, such as OH, H and OO, during the plasma treatments.

DOI： 10.1088/1361-6595/abbbd4

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Influences of substrate temperatures on etch rates of PECVD-SiN thin films with a CF4/H2 plasma 査読有り

Hsiao, SN; Nakane, K; Tsutsumi, T; Ishikawa, K; Sekine, M; Hori, M

APPLIED SURFACE SCIENCE 542 巻頁： 148550 2021年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Applied Surface Science

The dependence of substrate temperatures (50 to −20 °C) on etch rate in two kinds of PECVD SiN films were investigated by a CF<inf>4</inf>/H<inf>2</inf> mixture plasma. The XRR and XPS results indicate that the chemical composition and film density were almost identical for the films. The FTIR shows that the ratio of N[sbnd]H and Si[sbnd]H groups were found to be significantly different in the SiN films. The N[sbnd]H rich films exhibited a lower etch rate at −20 °C than that observed at room temperature or higher, whereas the Si[sbnd]H rich films showed a higher etch rate at −20 °C. We found that the fluorocarbon thickness was thicker in the Si[sbnd]H rich samples than N[sbnd]H rich samples. The fact suggests that hydrogen originated from the broken Si[sbnd]H bonds enhanced the polymerization, which causes the decrease of etch rate. A thinner fluorocarbon thickness was found in the Si[sbnd]H rich samples at low temperature, which results in the higher etch rate. Angular-resolved XPS indicates that N[sbnd]H bonding formed easier on film surface at −20 °C. These results indicate that the bonding structure and substrate temperature affected the fluorocarbon thickness, fluorine reaction probability and hydrogen dissociation during the SiN etching.

DOI： 10.1016/j.apsusc.2020.148550

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Selective etching of SiN against SiO2 and poly-Si films in hydrofluoroethane chemistry with a mixture of CH2FCHF2, O2, and Ar 査読有り

Hsiao, SN; Ishikawa, K; Hayashi, T; Ni, JW; Tsutsumi, T; Sekine, M; Hori, M

APPLIED SURFACE SCIENCE 541 巻頁： 148439 2021年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Applied Surface Science

Gas chemistry has a significant impact on etch selectivity in semiconductor device fabrication, which is important for realization of atomic-scale removal and formation of high-aspect ratio features. To widen the controllable changes in the etchant composition in etching processes, our previous calculation showed the possibility of the controllable generation of CH<inf>2</inf>F and CHF<inf>2</inf> related ions and radicals from a 1,1,2-trifluoroethane (CH<inf>2</inf>FCHF<inf>2</inf>) parent gas. The etch selectivity among silicon nitride (SiN), silicon dioxide (SiO<inf>2</inf>) and poly-Si films using CH<inf>2</inf>FCHF<inf>2</inf> plasma mixed with O<inf>2</inf> and Ar was investigated. The effects of the CH<inf>2</inf>FCHF<inf>2</inf> and O<inf>2</inf> partial pressures on the composition of CHF<inf>2</inf>+ and CH<inf>2</inf>F+ ions, which were measured with a quadrupole mass spectrometer, and on the possible reactions with respect to the CH<inf>2</inf>FCHF<inf>2</inf> and O<inf>2</inf> mixed gas phase were investigated using quantum chemical calculations. The etch selectivity was investigated through surface etching reactions for SiN, SiO<inf>2</inf>, and poly-Si films.

DOI： 10.1016/j.apsusc.2020.148439

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酸素ラジカル処理肥料溶液を用いた殺菌でのピロール化合物の重要性査読有り

岩田直幸, 石川健治, 堀勝, 田中宏昌, 伊藤昌文, 橋爪博司

応用物理学会学術講演会講演予稿集 2021.1 巻 ( 0 ) 頁： 1554 - 1554 2021年2月

かいわれ大根種子の発芽と発芽の成長に対する大気圧プラズマ照射の影響－種子の色と貯蔵の効果査読有り

奥村賢直, 石川健治, 古閑一憲, 白谷正治, ヴィダミルダズィネ, アトリパンカジ

応用物理学会学術講演会講演予稿集 2021.1 巻 ( 0 ) 頁： 1514 - 1514 2021年2月

FOREWORD Mechanistic understanding of cold atmospheric plasma applications 査読有り Open Access

Kurihara, K; Ishikawa, K; Takaki, K; Shiratani, M

JAPANESE JOURNAL OF APPLIED PHYSICS 60 巻 ( 2 ) 2021年2月

Growth inhibition effect on Trypanosoma brucei gambiense by the oxidative stress supplied from low-temperature plasma at atmospheric pressure 査読有り Open Access

Yokoyama, N; Sivakumar, T; Ikehara, S; Akimoto, Y; Yamaguchi, T; Wakai, K; Ishikawa, K; Hori, M; Shimizu, T; Sakakita, H; Ikehara, Y

JAPANESE JOURNAL OF APPLIED PHYSICS 60 巻 ( 2 ) 頁： 020601 2021年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Journal of Applied Physics

Trypanosoma brucei (Tb) is a pathogenic protozoan causing sleeping sickness in humans. Despite little knowledge of how the produced reactive oxygen species (ROS) kills this protozoan, the research on the killing mechanism using chemical compounds and the phagosome in the macrophages has suggested that the protozoan is highly susceptible to the increased oxidative stress. Because the prescribed drug can react with various kinds of molecules and the second produced intermediate compounds, in this study, we clarified the immediate killing effect on Tb in the condition of increased oxidative stress using a low-temperature plasma at atmospheric pressure (LTP) equipment. Results Show the significant growth inhibition of Tb in the LTP-treated medium, the loss of morphological homeostasis with twisted to puffed appearance, and demonstrated the swelled changes on mitochondria and endoplasmic reticulum. In conclusion, this study revealed how the increased oxidative stress kills Tb using LTP technology.

DOI： 10.35848/1347-4065/abd464

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Scopus

Effects of Carbon Nanowalls (CNWs) Substrates on Soft Ionization of Low-Molecular-Weight Organic Compounds in Surface-Assisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) 査読有り Open Access

Sakai, R; Ichikawa, T; Kondo, H; Ishikawa, K; Shimizu, N; Ohta, T; Hiramatsu, M; Hori, M

NANOMATERIALS 11 巻 ( 2 ) 頁： 1 - 11 2021年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nanomaterials

Carbon nanowalls (CNWs), which are vertically oriented multi-layer graphene sheets, were employed in surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) measurements to detect low-molecular-weight organic compounds. CNWs substrates with widely different wall-to-wall distances from 142 to 467 nm were synthesized using a radical-injection plasma-enhanced chemical vapor deposition (RI-PECVD) system with nanosecond pulse biasing to a sample stage. When survival yield (SY) values of N-benzylpyridinium chloride (N-BP-Cl) were examined, which is commonly used to evaluate desorption/ionization efficiency, a narrower wall-to-wall distance presented a higher SY value. The highest SY value of 0.97 was realized at 4 mJ/cm2 for the highest-density CNWs with a wall-to-wall distance of 142 nm. The laser desorption/ionization effect of arginine, an amino acid, was also investigated. When CNWs with a narrower wall-to-wall distance were used, the signal-to-noise (SN) ratios of the arginine signals were increased, while the intensity ratios of fragment ions to arginine signals were suppressed. Therefore, the CNWs nanostructures are a powerful tool when used as a SALDI substrate for the highly efficient desorption/ionization of low-molecular-weight biomolecules.

DOI： 10.3390/nano11020262

Impact of seed color and storage time on the radish seed germination and sprout growth in plasma agriculture 査読有り国際共著 Open Access

Attri, P; Ishikawa, K; Okumura, T; Koga, K; Shiratani, M; Mildaziene, V

SCIENTIFIC REPORTS 11 巻 ( 1 ) 頁： 2539 2021年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

The use of low-temperature plasma for the pre-sowing seed treatment is still in the early stage of research; thus, numerous factors affecting germination percentage, seedling growth, and yield remains unknown. This study aimed to estimate how two critical factors, such as harvest year and seed coat color, affect the percentage of germination and seedling growth after plasma treatment. Radish seeds stored for 2 and 1 year after harvesting (harvested in 2017 and 2018) were sorted into two colors (brown and grey) to investigate the plasma effect on harvest year and seed coat color. We analyzed the amounts of seed phytohormones and antioxidant (γ-tocopherol) were analyzed using mass spectrometry, and physical changes were studied using SEM, EDX, and EPR to understand the mechanism of plasma-induced changes in radish seeds. The obtained results revealed that plasma treatment on seeds affects the germination kinetics, and the maximal germination percentage depends on seed color and the time of seed storage after harvest. Through this study, for the first time, we demonstrated that physical and chemical changes in radish seeds after plasma treatment depends upon the seed color and harvest year. Positive effects of plasma treatment on growth are stronger for sprouts from seeds harvested in 2017 than in 2018. The plasma treatment effect on the sprouts germinated from grey seeds effect was stronger than sprouts from brown radish seeds. The amounts of gibberellin A3 and abscisic acid in control seeds strongly depended on the seed color, and plasma induced changes were better in grey seeds harvested in 2017. Therefore, this study reveals that Air scalar-DBD plasma's reactive oxygen and nitrogen species (RONS) can efficiently accelerate germination and growth in older seeds.

DOI： 10.1038/s41598-021-81175-x

Insights into normothermic treatment with direct irradiation of atmospheric pressure plasma for biological applications 査読有り

Yoshimura S., Otsubo Y., Yamashita A., Ishikawa K.

Japanese Journal of Applied Physics 60 巻 ( 1 ) 頁： 010502 2021年1月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Journal of Applied Physics

Characterizing the interactions between plasma and living organisms has become a multidisciplinary topic in the field of low-temperature plasma science and technology. Living organisms are hierarchically comprised of cells, tissues, organs, and organ systems. Adaptive responses are systematically controlled by the state of the surrounding environment, such as when living organisms are irradiated with discharge plasma. This review is written from a biological perspective and focuses on the importance of gas temperature control in nonequilibrium atmospheric pressure plasmas. We discuss the critical parameters associated with direct plasma treatments of living organisms. This review provides an assessment of the status of this research field and addresses the prospects for further developments in understanding the interactions between plasma and living organisms. We address the importance and necessity of normothermic plasma treatment, where an experimental system involving living organisms is controlled at an optimal temperature, which plays a significant role in plasma biology.

DOI： 10.35848/1347-4065/abcbd2

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Scopus

Reduction in photon-induced interface defects by optimal pulse repetition rate in the pulse-modulated inductively coupled plasma 査読有り

Miyoshi Y., Ishikawa K., Sekine M., Hori M., Tatsumi T.

Japanese Journal of Applied Physics 60 巻 ( 1 ) 頁： 010906 2021年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Journal of Applied Physics

The ultraviolet photon-induced interface defects that degrade the performance of a semiconductor device are reduced by the optimal pulse repetition rate of a pulse-modulated inductively coupled plasma. The defect density depends on the pulse repetition rates; it takes minimum value at a few hundred pulses s−1 and peaks at a few k pulses s−1. The repetition rate-dependent behavior is suggested to be caused by the transient behavior between the plasma's ON and OFF phases. Note that controlling the transient behavior for reducing the photon-induced damage is essential.

DOI： 10.35848/1347-4065/abd113

Web of Science

Scopus

Improvement of yield and grain quality by periodic cold plasma treatment with rice plants in a paddy field 査読有り

Hashizume, H; Kitano, H; Mizuno, H; Abe, A; Yuasa, G; Tohno, S; Tanaka, H; Ishikawa, K; Matsumoto, S; Sakakibara, H; Nikawa, S; Maeshima, M; Mizuno, M; Hori, M

PLASMA PROCESSES AND POLYMERS 18 巻 ( 1 ) 頁： 2000181 2021年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Plasma Processes and Polymers

The application of cold plasma has attracted considerable attention in the field of agriculture. We examined the effects of plasma irradiation and treatment with plasma-activated Ringer's lactate solution (PAL) on rice seedlings in a paddy field. Irradiation during the vegetative growth period increased seedling growth, panicle number, and grain yield. In contrast, treatment during the reproductive growth period had a negative or no effect. Moreover, treatment with PAL solution promoted the growth of the main stem, such as grain number and panicle weight, and grain quality, but the grain yield from the whole plant was decreased. The results suggest that cold plasma treatment of rice seedlings is effective for improving plant growth, grain yield, and grain quality.

DOI： 10.1002/ppap.202000181

Web of Science

Scopus

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