研究者詳細 - 石川　健治

Li Jiang, Hao Zheng, Moe Ishida, Qinying Lyu, Shinya Akatsuka, Yashiro Motooka, Kotaro Sato, Yoshitaka Sekido, Kae Nakamura, Hiromasa Tanaka, Kenji Ishikawa, Hiroaki Kajiyama, Masaaki Mizuno, Masaru Hori, and Shinya Toyokuni

Free Radical Biology and Medicine 214 巻頁： 28 - 41 2024年2月

Surface sulfurization of amorphous carbon films in the chemistry of oxygen plasma added with SO2 or OCS for high-aspect-ratio etching 査読有り Open Access

Kenji Ishikawa, Thi-Thuy-Nga Nguyen, Yuta Aoki, Hiroyasu Sato, Junichi Kawakami, Shuji Tsuno, Shin-Nan Hsiao, and Masaru Hori

Applied Surface Science 645 巻頁： 158876 2024年2月

Oxygen radical irradiation transforms an organic fertilizer l-tryptophan into an environment and human-friendly bactericide 査読有り Open Access

Naoyuki Iwata, Kenji Ishikawa, Yasuhiro Nishikawa, Hiroyuki Kato, Motoyuki Shimizu, Masashi Kato, Hiromasa Tanaka, Masafumi Ito, and Masaru Hori

Environmental Technology and Innovation 33 巻頁： 103496 2024年2月

High linear energy transfer (LET) nature of alanine radical yield by soft X-ray irradiations studied by electron spin resonance (ESR) applications 査読有り

Seiko Nakagawa, Akinari Yokoya, Maki Ohara, Noriko Usami, Mizue Asada, Motoyasu Fujiwara, Toshikazu Nakamura, and Kenji Ishikawa

Radiation Physics and Chemistry 214 巻頁： 111304 2024年1月

Cold Atmospheric Pressure Plasma-Activated Liquids for Cancer Treatment 査読有り

Miron C., Hiromasa T., Britun N., Hashizume H., Ishikawa K., Du L., Yamakawa T., Kurebayashi Y., Kondo T., Kondo H., Kajiyama H., Toyokuni S., Mizuno M., Hori M.

IFMBE Proceedings 111 IFMBE 巻頁： 150 - 162 2024年

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）出版者・発行元：IFMBE Proceedings

Low-temperature plasma (LTP) is a promising tool that can assist in cancer treatment. Plasma-treated liquids have shown a selective cytotoxic effect on cancer cells attributed to reactive species formed in discharge, but this mechanism is not completely understood. In this study, the chemical compounds formed by plasma irradiation of Ringer’s lactate solutions and their effects on non-tumorigenic breast epithelial cells (MCF-10A) and breast cancer cells (MCF-7) were investigated. Among these compounds, glyceric acid increased the cell viability by more than two-fold compared to the control samples for MCF-10A and MCF-7 cells, whereas the tricarballylic acid had a pronounced cytotoxic effect on the cells when incubated with solutions of 0.6 mM to 50 mM concentrations. A good selectivity in killing the cancer cells was observed when the chemical compounds identified in plasma-treated liquids (such as ethyl acetate, glyceric acid, and tricarballylic acid) were used in a mixture solution of a certain concentration. The results show that the LTP-generated chemical compounds have both, stimulatory and inhibitory effects on cell viability, and the best selectivity is achieved only when these compounds are combined in a certain amount and have a synergistic effect, completely killing only the cancer cells.

DOI： 10.1007/978-3-031-62523-7_17

Scopus

Bias-supply timing tailored to the aspect ratio dependence of silicon trench etching in Ar plasma with alternately injected C4F8 and SF6 査読有り Open Access

Taito Yoshie, Kenji Ishikawa, Thi-Thuy-Nga Nguyen, Shih-Nan Hsiao, Takayoshi Tsutsumi, Makoto Sekine, and Masaru Hori

Applied Surface Science 638 巻頁： 157981 2023年11月

An approach to reduce surface charging with cryogenic plasma etching using hydrogen-fluoride contained gases 査読有り

Shih-Nan Hsiao, Makoto Sekine, Kenji Ishikawa, Yuki Iijima, Yoshinobu Ohya, and Masaru Hori

Applied Physics Letters 123 巻 ( 21 ) 頁： 1 - 4 2023年11月

Gas-phase study of the behavior of trimethyl gallium and triethyl gallium by optical emission spectroscopy and quadrupole mass spectroscopy for the growth of GaN by REMOCVD (radical-enhanced metalorganic chemical vapor deposition) 査読有り

Arun Kumar Dhasiyan, Swathy Jayaprasad, Frank Wilson Amalraj, Naohiro Shimizu, Osamu Oda, Kenji Ishikawa, and Masaru Hori

Japanese Journal of Applied Physics 62 巻 ( SN ) 頁： SN1019 2023年11月

Deposition of carbon-based materials directly on copper foil and nickel foam as 2D-and 3D-networked metal substrates by in-liquid plasma 査読有り Open Access

Ma. Shanlene D.C. Dela Vega, Thi-Thuy-Nga Nguyen, Hiroki Kondo, Takayoshi Tsutsumi, Kenji Ishikawa, and Masaru Hori

Plasma Processes and Polymers 20 巻 ( 11 ) 頁： 1 - 5 2023年11月

低温プラズマおよびハイパーサーミア併用効果を用いたがん治療の可能性招待有り査読有り

近藤隆, 橋爪博司, 田中宏昌, 石川健治, 齋藤淳一, 堀勝

Thermal Medicine 39 巻 ( 3 ) 頁： 21 - 30 2023年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本ハイパーサーミア学会

プラズマは固体・液体・気体に続く物質の第4の状態である．狭義のプラズマは，気体を構成する分子が電離し，陽イオンと電子に分かれて運動している状態であり，電離気体に相当する．いわゆる熱プラズマはすでに消化管や鼻腔表面の組織凝固壊死を誘導する熱凝固装置治療に使われている．近年，低温プラズマ技術の発展が目覚ましく，止血，がん治療，遺伝子・薬物導入，殺菌・滅菌，創傷治療等，多くの医療分野への利用が注目されている．低温大気圧プラズマは水溶液中には多量の活性種を生成する．但し，直接照射の場合の課題はその深達性にある．そこで，我々はハイパーサーミアの併用により大気圧プラズマ誘発活性種がより多く細胞内に導入されることを期待してアポトーシスを指標にその増強効果を検討した．　実験にはヒトリンパ腫細胞株であるU937細胞を用いた．プラズマにはHeプラズマを用いた．その結果，単独では細胞致死効果を示さない42 ℃の温熱処理を付加することでプラズマ併用により相乗的なアポトーシスの増強効果が得られた．同時に細胞内活性酸素種も増加した．単独では致死効果が十分でない場合でもハイパーサーミアを付加することで細胞内への活性酸素種の導入が増え，致死効果の増強に寄与したものと思われる．　最近，プラズマ照射された溶液の生物作用が注目されている．プラズマ活性培養液やプラズマ活性乳酸リンゲル液のがん細胞致死効果が注目されている．これらプラズマ活性化溶液と温熱処理は細胞内に酸化ストレス誘導をすることが知られており，ハイパーサーミアとの併用による相乗効果が期待される．本稿ではプラズマを用いたがん治療の現状について解説するともにハイパーサーミア併用の有用性について言及する．

DOI： 10.3191/thermalmed.39.21

CiNii Research

Development of an experimental system for cell viability assays of yeasts using gas-temperature controllable plasma jets 査読有り Open Access

Yoshimura, S; Otsubo, Y; Yamashita, A; Johzuka, K; Tsutsumi, T; Ishikawa, K; Hori, M

Japanese Journal of Applied Physics 62 巻 ( SL ) 2023年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Journal of Applied Physics

The characteristics of a gas-temperature-controllable atmospheric-pressure helium plasma jet and the development of an experimental system for cell viability assays of yeasts (fission yeast Schizosaccharomyces pombe and budding yeast Saccharomyces cerevisiae) are reported. The physicochemical properties of the plasma plume, which can maintain the temperature of the irradiated object at a temperature suitable for yeast, were not significantly different from those of a typical helium plasma jet. Furthermore, good reproducibility of cell viability was observed when gas temperature, gas flow rate, applied high voltage, and irradiation distance remained fixed, and only irradiation time was used as a parameter. This experimental system allows us to carry out various experiments, such as the search for plasma-resistant mutants that will contribute to the identification of genes involved in resistance to direct plasma irradiation.

DOI： 10.35848/1347-4065/acd4ca

Web of Science

Scopus

Organic decomposition and synthesis reactions in lactated solution exposed to nonequilibrium atmospheric pressure plasma 査読有り

Liu, Y; Ishikawa, K; Tanaka, H; Miron, C; Kondo, T; Nakamura, K; Mizuno, M; Kajiyama, H; Toyokuni, S; Hori, M

PLASMA PROCESSES AND POLYMERS 20 巻 ( 5 ) 2023年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Plasma Processes and Polymers

Lactate is used in the food and pharmaceutical industries and is a crucial intermediate for synthesis. Plasma-activated lactate (PAL) in Ringer's solution was recently shown to have effective antitumor action. Small molecule aldehydes, ketones, and organic acids were produced from lactate during plasma exposure, and five-membered conjugated lactone isomers of furanone (C5H6O2) were detected formed by interactions of lactate or its fragments with •OH, organic radicals, and H2O2. 2,3-Dimethyl-tartaric acid may be the effective component in PAL for the selective killing of cancer but not normal cells and possible pathways for its synthesis are provided. Aqueous reaction mechanisms are explained, including dehydration, esterification, hydrolysis, and dimerization. This study will help develop novel cancer therapies and further plasma organic chemistry.

DOI： 10.1002/ppap.202200193

Web of Science

Scopus

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