研究者詳細 - 豊國　伸哉

論文 - 豊國　伸哉

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CHARACTERIZATION OF IMMORTALIZED CELL-LINES ISOLATED FROM A SOFT-TISSUE TUMOR-DERIVED FROM A RABBIT SUBCHRONICALLY EXPOSED TO 60HZ MAGNETIC-FIELDS AT 1-G

NING, JT; BUSHAR, G; LI, L; TOYOKUNI, S; THOMAS, D; CRESS, L; CZERSKA, EM; SWICORD, ML; ELSON, E; DAVIS, CC

ELECTRICITY AND MAGNETISM IN BIOLOGY AND MEDICINE 頁： 405 - 408 1993年

PATHOLOGICAL EVALUATION OF RABBITS SUBCHRONICALLY EXPOSED TO 60HZ MAGNETIC-FIELDS AT 1 G AND 5 G

NING, JT; TOYOKUNI, S; THOMAS, D; CZERSKA, EM; CASAMENTO, J; SWICORD, ML; DAVIS, CC; ELSON, E

ELECTRICITY AND MAGNETISM IN BIOLOGY AND MEDICINE 頁： 835 - 838 1993年

DOSE-DEPENDENT HEALTH-EFFECTS EXHIBITED IN RABBITS EXPOSED TO 60HZ MAGNETIC-FIELDS AT 1 G AND 5 G

NING, JT; CZERSKA, EM; CASAMENTO, J; TOYOKUNI, S; SWICORD, ML; STCHARLES, C; EINSMANN, FE; PERRY, B; ELSON, E; DAVIS, CC

ELECTRICITY AND MAGNETISM IN BIOLOGY AND MEDICINE 頁： 845 - 848 1993年

PATHOLOGICAL EVALUATION OF RABBITS SUBCHRONICALLY EXPOSED TO 60HZ MAGNETIC-FIELDS AT 1 G AND 5 G 国際誌

NING, JT, TOYOKUNI, S, THOMAS, D, CZERSKA, EM, CASAMENTO, J, SWICORD, ML, DAVIS, CC, ELSON, E

ELECTRICITY AND MAGNETISM IN BIOLOGY AND MEDICINE 頁： 835 - 838 1993年

DOSE-DEPENDENT HEALTH-EFFECTS EXHIBITED IN RABBITS EXPOSED TO 60HZ MAGNETIC-FIELDS AT 1 G AND 5 G 国際誌

NING, JT, CZERSKA, EM, CASAMENTO, J, TOYOKUNI, S, SWICORD, ML, STCHARLES, C, EINSMANN, FE, PERRY, B, ELSON, E, DAVIS, CC

ELECTRICITY AND MAGNETISM IN BIOLOGY AND MEDICINE 頁： 845 - 848 1993年

CHARACTERIZATION OF IMMORTALIZED CELL-LINES ISOLATED FROM A SOFT-TISSUE TUMOR-DERIVED FROM A RABBIT SUBCHRONICALLY EXPOSED TO 60HZ MAGNETIC-FIELDS AT 1-G 査読有り国際共著国際誌

NING, JT, BUSHAR, G, LI, L, TOYOKUNI, S, THOMAS, D, CRESS, L, CZERSKA, EM, SWICORD, ML, ELSON, E, DAVIS, CC

ELECTRICITY AND MAGNETISM IN BIOLOGY AND MEDICINE 頁： 405 - 408 1993年

IRON-MEDIATED DNA DAMAGE - SENSITIVE DETECTION OF DNA STRAND BREAKAGE CATALYZED BY IRON

TOYOKUNI S, SAGRIPANTI JL

JOURNAL OF INORGANIC BIOCHEMISTRY 47 巻 ( 3-4 ) 頁： 241 - 248 1992年8月

REPORT OF A PATIENT WITH POEMS-TAKATSUKI-CROW-FUKASE SYNDROME ASSOCIATED WITH FOCAL SPINAL PACHYMENINGEAL AMYLOIDOSIS

TOYOKUNI S, EBINA Y, OKADA S, YAMABE H, ISHIKAWA T, UCHIYAMA T, YODOI J, UCHINO H, TAKATSUKI K

CANCER 70 巻 ( 4 ) 頁： 882 - 886 1992年8月

Report of a patient with POEMS/takatsuki/crow‐fukase syndrome associated with focal spinal pachymeningeal amyloidosis

Toyokuni S., Ebina Y., Okada S., Yamabe H., Ishikawa T., Uchiyama T., Yodoi J., Uchino H., Takatsuki K.

Cancer 70 巻 ( 4 ) 頁： 882 - 886 1992年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Cancer

The authors present the results of an autopsy of a 67‐year‐old Japanese man with POEMS/Takatsuki/Crow‐Fukase syndrome (P/T/CFS) diagnosed in 1972. Each component of the syndrome was gradually recognized after the resection of lumbar vertebral solitary plasma‐cytoma in 1967. The patient died in 1989 of generalized infection and renal failure. Autopsy revealed in the vertebral canal between the fifth and seventh thoracic vertebrae dorsal pachymeningeal fibrosis, with prominent amyloid deposition that oppressed the spinal cord. This condition was consistent with the final neurologic manifestation of the patient, bilateral motor and sensory disturbance below the sixth thoracic level. Myelopathy remained clinically unnoticed because neurologic disturbance had begun as peripheral polyneuropathy. Normo‐cellular marrow with heterogeneously scattered lambda light chain‐positive plasma cells and degeneration of the myelinated fibers of sciatic nerve also were observed. This is the first report of focal spinal amyloidosis associated with P/T/CFS. Cancer 1992; 70:882–886. Copyright © 1992 American Cancer Society

DOI： 10.1002/1097-0142(19920815)70:4<882::AID-CNCR2820700426>3.0.CO;2-R

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REPORT OF A PATIENT WITH POEMS-TAKATSUKI-CROW-FUKASE SYNDROME ASSOCIATED WITH FOCAL SPINAL PACHYMENINGEAL AMYLOIDOSIS

TOYOKUNI S, EBINA Y, OKADA S, YAMABE H, ISHIKAWA T, UCHIYAMA T, YODOI J, UCHINO H, TAKATSUKI K

CANCER 70 巻 ( 4 ) 頁： 882 - 886 1992年8月

IRON-MEDIATED DNA DAMAGE - SENSITIVE DETECTION OF DNA STRAND BREAKAGE CATALYZED BY IRON

TOYOKUNI S, SAGRIPANTI JL

JOURNAL OF INORGANIC BIOCHEMISTRY 47 巻 ( 3-4 ) 頁： 241 - 248 1992年8月

肝未分化肉腫の1例 Open Access

奥山隆三, 豊國伸哉, 岡田茂, 中嶋安彬, 山辺博彦, 韓秀〓, 森敬一郎, 小沢和惠

日臨細胞会誌 31 巻頁： 89 - 90 1992年

肝未分化肉腫の１例

奥山隆三, 豊國伸哉, 岡田茂, 中嶋安彬, 山辺博彦, 韓秀絃, 森敬一郎, 小沢和恵

日本臨床細胞学会雑誌 31 巻 ( 1 ) 頁： 89 - 90 1992年

肝未分化肉腫の1例 Open Access

奥山隆三, 豊國伸哉, 岡田茂, 中嶋安彬, 山辺博彦, 韓秀〓, 森敬一郎, 小沢和惠

日臨細胞会誌 31 巻頁： 89 - 90 1992年

Iron-mediated DNA damage: Sensitive detection of DNA strand breakage catalyzed by iron

Toyokuni S., Sagripanti J.

Journal of Inorganic Biochemistry 47 巻 ( 1 ) 頁： 241 - 248 1992年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Inorganic Biochemistry

Oxidative DNA damage is involved in mutagenesis, carcinogenesis, aging, radiation effects, and the action of several anticancer drugs. Accumulated evidence indicates that iron may play an important role in those processes. We studied the in vitro effect of low concentrations of Fe(II) alone or Fe(III) in the presence of reducing agents on supercoiled plasmid DNA. The assay, based on the relaxation and linearization of supercoiled DNA, is simple yet sensitive and quantitative. Iron mediated the production of single and double strand breaks in supercoiled DNA. Iron chelators, free radical scavengers, and enzymes of the oxygen reduction pathways modulated the DNA damage. Fe(III)-nitrilotriacetate (NTA) plus either H2O2, L-ascorbate, or L-cysteine produced single and double strand breaks as a function of reductant concentration. A combination of 0.1 μM Fe(III)-NTA and 100 μM L-ascorbate induced detectable DNA strand breaks after 30 min at 24°C. Whereas superoxide dismutase was inhibitory only in systems containing H2O2 as reductant, catalase inhibited DNA breakage in all the iron-mediated systems studied. The effect of scavengers and enzymes indicates that H2O2 and .OH are involved in the DNA damaging process. These reactions may account for the toxicity and carcinogenicity associated with iron overload. © 1992.

DOI： 10.1016/0162-0134(92)84069-Y

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Erratum: Combined histochemical and biochemical analysis of sex hormone dependence of ferric nitrilotriacetate-induced renal lipid peroxidation in ddY mice (Cancer Research (September 1, 1990) (5574-5580)) 査読有り国際誌

Toyokuni

Cancer Research 52 巻 ( 21 ) 1992年

Histochemical detection of burn-induced lipid peroxidation in sebaceous glands of rat skin. 国際誌

Kitajima T, Hamanaka H, Miyachi Y, Ono Y, Moriguchi T, Toyokuni S, Imamura S

The Journal of dermatology 18 巻 ( 7 ) 頁： 393 - 6 1991年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Dermatology

Increased lipid peroxide levels both in skin and serum have been reported after cutaneous thermal injury. However, it still remains unclear where lipid peroxides are produced at the site of burned skin. In the present study, a histochemical method using cold Schiff's reagent was applied in order to detect the localization of lipid peroxide. Schiff positivity was detected in sebaceous glands, and the extent of positivity seemed to correlate with the serum lipid peroxide levels. These results may suggest that lipid peroxides produced in sebaceous glands after thermal injury enter the blood stream and are partially responsible for the elevated serum lipid peroxide levels.

DOI： 10.1111/j.1346-8138.1991.tb03104.x

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SEX-DIFFERENCES IN THE LOCALIZATION AND SEVERITY OF FERRIC NITRILOTRIACETATE-INDUCED LIPID-PEROXIDATION IN THE MOUSE KIDNEY

OKADA, S; FUKUNAGA, Y; HAMAZAKI, S; YAMADA, Y; TOYOKUNI, S

ACTA PATHOLOGICA JAPONICA 41 巻 ( 3 ) 頁： 221 - 226 1991年3月

SEX-DIFFERENCES IN THE LOCALIZATION AND SEVERITY OF FERRIC NITRILOTRIACETATE-INDUCED LIPID-PEROXIDATION IN THE MOUSE KIDNEY

OKADA S, FUKUNAGA Y, HAMAZAKI S, YAMADA Y, TOYOKUNI S

ACTA PATHOLOGICA JAPONICA 41 巻 ( 3 ) 頁： 221 - 226 1991年3月

Sex Differences in the Localization and Severity of Ferric Nitrilotriacetate‐induced Lipid Peroxidation in the Mouse Kidney 国際誌

Okada S., Fukunaga Y., Hamazaki S., Yamada Y., Toyokuni S.

Pathology International 41 巻 ( 3 ) 頁： 221 - 226 1991年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Pathology International

Male mice are much more susceptible than female mice to acute renal proximal tubular necrosis as well as the carcinogenic effect induced by an iron chelate, ferric nitrilotriacetate (Fe‐NTA). In the present study, iron‐promoted lipid peroxidation was analyzed histochemically in frozen kidney sections using cold Schiffs reagent and biochemically by measuring thiobarbituric acid‐reactive substance in the kidney. When untreated mouse frozen kidney sections were exposed to ascorbic acid‐Fe‐NTA (0.8 mM, 0.2 mM and 0.4 mM) in vitro for 40 min and washed, diffuse Schiff positivity was obtained along the proximal tubules, and no sex differences were evident. When non‐reduced Fe‐NTA (0.2 mM and 0.4 mM) was layered on untreated kidney sections from males, about half of the cortical proximal tubules showed a positive reaction with Schiffs reagent, whereas in females the proximal tubules of the outer stripe of the outer medulla were positive. In an ex vivo study, 30 to 40 min after i.p. injection of Fe‐NTA (5 mg Fe/kg), Schiff‐positive areas corresponded to those observed in the in vitro non‐reduced Fe‐NTA study in each sex. However, in males, the positive tubular cells gradually became necrotic, whereas in females the positivity disappeared with time and there was no tubular necrosis. Results of the thiobarbituric acid test were correlated with the above findings. In conclusion, the localization and severity of FeNTA induced lipid peroxidation in the tubules differed between the sexes. We suspect that these results reflect functional heterogeneity in the ability of the tubules to reduce iron. Copyright © 1991, Wiley Blackwell. All rights reserved

DOI： 10.1111/j.1440-1827.1991.tb01651.x

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