研究者詳細 - 豊國　伸哉

論文 - 豊國　伸哉

分割表示 1,287 件中 341 - 360 件目／全件表示 >>

Preliminary characterization of a murine model for 1-bromopropane neurotoxicity: Role of cytochrome P450. 査読有り

Zong C, Garner CE, Huang C, Zhang X, Zhang L, Chang J, Toyokuni S, Ito H, Kato M, Sakurai T, Ichihara S, Ichihara G.

Toxicol Lett. 258 巻頁： 249-58 2016年9月

Biphasic effects of l-ascorbate on the tumoricidal activity of non-thermal plasma against malignant mesothelioma cells. 査読有り

Shi L, Wang Y, Ito F, Okazaki Y, Tanaka H, Mizuno M, Hori M, Richardson DR, Toyokuni S.

Arch Biochem Biophys. 605 巻頁： 106-16 2016年9月

Antenatal Saireito (TJ-114) Can Improve Pulmonary Hypoplasia and Pulmonary Vascular Remodeling in Nitrofen-Induced Congenital Diaphragmatic Hernia. 査読有り国際誌

Hirako S, Tsuda H, Kotani T, Sumigama S, Mano Y, Nakano T, Imai K, Li H, Toyokuni S, Kikkawa F

Phytotherapy research : PTR 30 巻 ( 9 ) 頁： 1474 - 80 2016年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Phytotherapy Research

Congenital diaphragmatic hernia (CDH) can induce lung hypoplasia and pulmonary hypertension and is associated with high mortality. The purpose of this study is to examine the efficacy and safety of antenatal Saireito (TJ-114), a traditional Japanese herbal medicine, in a rat CDH model. Sprague-Dawley rats were exposed to an herbicide (nitrofen, 100 mg) on embryonic day 9 (E9) to induce CDH, and antenatal Saireito (2000 mg/kg/day) was orally administered from E10 to E20. On E21, fetuses were delivered. Antenatal Saireito significantly decreased the incidence of CDH (p < 0.01), increased lung volume (p < 0.01), improved alveolarization and pulmonary artery remodeling using histological analysis, and improved respiratory function using gasometric analysis (pH; p < 0.05, and PCO2; p < 0.01). In addition, antenatal Saireito significantly decreased endothelin-1 and endothelin receptor A expression in the pulmonary arteries. Taken together, our results demonstrated that antenatal Saireito can improve fetal pulmonary hypoplasia and pulmonary vascular remodeling and, as a result, can improve respiratory function in a rat CDH model. Copyright © 2016 John Wiley & Sons, Ltd.

DOI： 10.1002/ptr.5645

Molecular hydrogen suppresses activated Wnt/beta-catenin signaling 査読有り国際誌 Open Access

Lin Yingni, Ohkawara Bisei, Ito Mikako, Misawa Nobuaki, Miyamoto Kentaro, Takegami Yasuhiko, Masuda Akio, Toyokuni Shinya, Ohno Kinji

SCIENTIFIC REPORTS 6 巻 ( 6 ) 頁： 31986 2016年8月

Contrasting intra- and extracellular distribution of catalytic ferrous iron in ovalbumin-induced peritonitis. 査読有り国際誌

Ito F, Nishiyama T, Shi L, Mori M, Hirayama T, Nagasawa H, Yasui H, Toyokuni S

Biochemical and biophysical research communications 476 巻 ( 4 ) 頁： 600 - 606 2016年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Biochemical and Biophysical Research Communications

Iron is an essential nutrient for every type of life on earth. However, excess iron is cytotoxic and can lead to an increased cancer risk in humans. Catalytic ferrous iron [Fe(II)] is an initiator of the Fenton reaction, which causes oxidative stress by generating hydroxyl radicals. Recently, it became possible to localize catalytic Fe(II) in situ with a turn-on fluorescent probe, RhoNox-1. Here, we screened each organ/cell of rats to globally evaluate the distribution of catalytic Fe(II) and found that eosinophils showed the highest abundance. In various cells, lysosomes were the major organelle, sharing ∼40–80% of RhoNox-1 fluorescence. We then used an ovalbumin-induced allergic peritonitis model to study the dynamics of catalytic Fe(II). Peritoneal lavage revealed that the total iron contents per cell were significantly decreased, whereas an increase in the number of inflammatory cells (macrophages, neutrophils, eosinophils and lymphocytes) resulted in an increased total iron content of the peritoneal inflammatory cells. Notably, macrophages, eosinophils and neutrophils exhibited significantly increased catalytic Fe(II) with increased DMT1 expression and decreased ferritin expression, though catalytic Fe(II) was significantly decreased in the peritoneal lavage fluid. In conclusion, catalytic Fe(II) in situ more directly reflects cellular activity and the accompanying pathology than total iron does.

DOI： 10.1016/j.bbrc.2016.06.003

Contrasting intra- and extracellular distribution of catalytic ferrous iron in ovalbumin-induced peritonitis. 査読有り

Ito F, Nishiyama T, Shi L, Mori M, Hirayama T, Nagasawa H, Yasui H, Toyokuni S.

Biochem Biophys Res Commun. 476 巻 ( 4 ) 頁： 600-6 2016年8月

Molecular hydrogen suppresses activated Wnt/β-catenin signaling. 査読有り

Lin Y, Ohkawara B, Ito M, Misawa N, Miyamoto K, Takegami Y, Masuda A, Toyokuni S, Ohno K.

Sci Rep. 25 巻 ( 6 ) 頁： 31986 2016年8月

Iron function and carcinogenesis 査読有り国際誌

Akatsuka S., Toyokuni S.

Nihon rinsho. Japanese journal of clinical medicine 74 巻 ( 7 ) 頁： 1168 - 1175 2016年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nihon rinsho. Japanese journal of clinical medicine

Though iron is an essential micronutrient for humans, the excess state is acknowledged to be associated with oncogenesis. For example, iron overload in the liver of the patients with hereditary hemocromatosis highly increases the risk of hepatocellular carcinoma. Also, as to asbestos-related mesothelioma, such kinds of asbestos with a higher iron content are considered to be more carcinogenic. Iron is a useful element, which enables fundamental functions for life such as oxygen carrying and electron transport. However, in the situation where organisms are unable to have good control of it, iron turns into a dangerous element which catalyzes generation of reactive oxygen. In this review, I first outline the relationships between iron and cancer in general, then give an explanation about iron-related animal carcinogenesis models.

Scopus

The emerging role of progesterone receptor membrane component 1 (PGRMC1) in cancer biology. 査読有り

Cahill MA, Jazayeri JA, Catalano SM, Toyokuni S, Kovacevic Z, Richardson DR.

Biochim Biophys Acta. 2016 Jul 22. pii: S0304-419X 巻 ( 16 ) 頁： 30049-X. 2016年7月

Dual preventive benefits of iron elimination by desferal in asbestos-induced mesothelial carcinogenesis 査読有り国際誌 Open Access

Jiang Li, Chew Shan-Hwu, Nakamura Kosuke, Ohara Yuuki, Akatsuka Shinya, Toyokuni Shinya

CANCER SCIENCE 107 巻 ( 7 ) 頁： 908 - 915 2016年7月

Possible therapeutic option of aqueous plasma for refractory ovarian cancer 査読有り国際誌

Kajiyama Hiroaki, Utsumi Fumi, Nakamura Kae, Tanaka Hiromasa, Mizuno Masaaki, Toyokuni Shinya, Hori Masaru, Kikkawa Fumitaka

CLINICAL PLASMA MEDICINE 4 巻 ( 1 ) 頁： 14 - 18 2016年7月

The emerging role of progesterone receptor membrane component 1 (PGRMC1) in cancer biology. 査読有り国際誌

Cahill MA, Jazayeri JA, Catalano SM, Toyokuni S, Kovacevic Z, Richardson DR

Biochim Biophys Acta. 2016 Jul 22. pii: S0304-419X 巻 ( 16 ) 頁： 30049-X. 2016年7月

[Iron function and carcinogenesis].

Akatsuka S, Toyokuni S

Nihon rinsho. Japanese journal of clinical medicine 74 巻 ( 7 ) 頁： 1168 - 75 2016年7月

[Iron function and carcinogenesis].

Akatsuka S, Toyokuni S

Nihon rinsho. Japanese journal of clinical medicine 74 巻 ( 7 ) 頁： 1168 - 75 2016年7月

Variable susceptibility of ovarian cancer cells to non-thermal plasma-activated medium. 査読有り

35 巻 ( 6 ) 頁： 3169-77 2016年6月

Dual preventive benefits of iron elimination by desferal in asbestos-induced mesothelial carcinogenesis. 査読有り

Jiang L, Chew SH, Nakamura K, Ohara Y, Akatsuka S, Toyokuni S.

Cancer Sci. 2016 Jul;107(7):908-15. 107 巻 ( 7 ) 頁： 908-15 2016年6月

Dual preventive benefits of iron elimination by desferal in asbestos-induced mesothelial carcinogenesis. 査読有り国際誌

Jiang L, Chew SH, Nakamura K, Ohara Y, Akatsuka S, Toyokuni S

Cancer Sci. 2016 Jul;107(7):908-15. 107 巻 ( 7 ) 頁： 908-15 2016年6月

Variable susceptibility of ovarian cancer cells to non-thermal plasma-activated medium. 査読有り国際誌

Utsumi F, Kajiyama H, Nakamura K, Tanaka H, Mizuno M, Toyokuni S, Hori M, Kikkawa F

Oncology reports 35 巻 ( 6 ) 頁： 3169 - 77 2016年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oncology Reports

Non- Thermal atmospheric pressure plasma has been widely studied in recent years in many fields,including cancer treatment. However,its efficiency for inducing apoptosis sometimes varies depending on the cell species and experimental conditions. The aim of this study was to elucidate what causes these differences in responses to plasma treatment. Using four ovarian cancer cell lines,the cell density had a markedly negative impact on the proliferation inhibition rate (PIR) and it was more obvious in OVCAR-3 and NOS2 cells. Furthermore,TOV21G and ES-2 cells were drastically sensitive to plasma- Activated medium (PAM) compared with the other two cell lines. We demonstrated that the proportion of reactive oxygen species and cell number had a marked impact on the effect of PAM against ovarian cancer cells. Additionally it was suggested that the morphological features of cells were also closely related to the sensitivity of cancer cells to the plasma treatment.

DOI： 10.3892/or.2016.4726

The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis-resistance to non-thermal plasma therapy 査読有り国際誌 Open Access

Toyokuni S.

Pathology International 66 巻 ( 5 ) 頁： 245 - 259 2016年5月

The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis-resistance to non-thermal plasma therapy. 招待有り査読有り国際誌

Toyokuni S

Pathol Int. 66 巻 ( 5 ) 頁： 245-259 2016年5月

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