研究者詳細 - 豊國　伸哉

論文 - 豊國　伸哉

分割表示 1,287 件中 521 - 540 件目／全件表示 >>

多層カーボンナノチューブの直径と剛性は、中皮細胞傷害と中皮腫形成に重要な因子である

永井裕崇, 岡崎泰昌, 周珊瑚, 三澤伸明, 山下依子, 赤塚慎也, 石原敏和, 山下享子, 吉川豊, 安井裕之, 蒋麗, 高橋隆, 市原学, 宮田耕充, 篠原久典, 豊國伸哉

日本病理学会会誌 101 巻 ( 1 ) 頁： 280 - 280 2012年3月

Array CGH Analysis Reveals Amplification of Met and AKT2 in Clear Cell Carcinoma of the Ovary 査読有り国際誌

Yamashita, Y; Akatsuka, S; Yatabe, Y; Toyokuni, S

LABORATORY INVESTIGATION 92 巻頁： 302A - 302A 2012年2月

Array CGH Analysis Reveals Amplification of Met and AKT2 in Clear Cell Carcinoma of the Ovary 査読有り国際誌

Yamashita, Y; Akatsuka, S; Yatabe, Y; Toyokuni, S

MODERN PATHOLOGY 25 巻頁： 302A - 302A 2012年2月

FGF2 mediates mouse spermatogonial stem cell self-renewal via upregulation of Etv5 and Bcl6b genes through MAP2K1 activation. 査読有り

Ishii K, Kanatsu-Shinohara M, Toyokuni S and Shinohara T.

Development 139 巻頁： 1734-1743 2012年

Differences and similarities between carbon nanotubes and asbestos fibers during mesothelial carcinogenesis. 査読有り

Nagai H and Toyokuni S.

Cancer Sci 103 巻頁： 1378-1390 2012年

The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis. 査読有り

Kobayashi H, Yamashita Y, Iwase A, Yoshikawa Y, Yasui H, Kawai Y, Uchida K, Uno N, Akatsuka S, Takahashi T, Kikkawa F, Toyokuni S.

Fertil Steril 98 巻頁： 415-422 2012年

Mitochondria and free radical studies on health, disease and pollusion (editorial). 招待有り

Majima HJ and Toyokuni S.

Free Radic Res 46 巻頁： 925-926 2012年

Distinct affinity of nuclear proteins to the surface of chrysotile and crocidolite. 招待有り査読有り Open Access

Kubo Y, Takenaka H, Nagai H and Toyokuni S.

J Clin Biochem Nutr 51 巻頁： 221-226 2012年

The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma. 査読有り

Elshazley M, Sato M, Hase T, Yamashita R, Yoshida K, Toyokuni S, Ishiguro F, Osada H, Sekido Y, Yokoi K, Usami N, Shames DS, Kondo M, Gazdar AF, Minna JD and Hasegawa Y.

INt J Cancer 131 巻頁： 2820-2831 2012年

YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle promoting genes. 査読有り

Mizuno T, Murakami H, Fujii M, Ishiguro F, Tanaka I, Kondo Y, Akatsuka S, Toyokuni S and Sekido Y.

Oncogene 31 巻頁： 5117-5122 2012年

Transient but not stable ZEB1 knockdown dramatically inhibits growth of malignant pleural mesothalioma cells. 査読有り

Horio M, Sato M, Takayama Y, Elshazley M, Yamashita R, Hase T, Yoshida K, Usami N, Yokoi K, Sekido Y, Kondo M, Toyokuni S, Gazdar AF, Minna JD and Hasegawa Y.

Ann Surg Oncol 19 巻 ( Suppl 3 ) 頁： 634-645 2012年

Genome-wide assessment of oxidatively generated DNA damage. 査読有り

Akatsuka S and Toyokuni S.

Free Radic Res 46 巻頁： 523-530 2012年

Bovine lactoferrin ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats. 査読有り

Okazaki Y, Kono H, Kuriki R, Funahashi S, Fushimi S, Iqbal M, Okada S and Toyokuni S.

J Clin Biochem Nutr 51 巻頁： 84-90 2012年

Differences and similarities between carbon nanotubes and asbestos fibers during mesothelial carcinogenesis. 査読有り

Nagai H, Toyokuni S

Cancer Sci 103 巻頁： 1378-1390 2012年

FGF2 mediates mouse spermatogonial stem cell self-renewal via upregulation of Etv5 and Bcl6b genes through MAP2K1 activation. 査読有り

Ishii K, Kanatsu-Shinohara M, Toyokuni S, Shinohara T

Development 139 巻頁： 1734-1743 2012年

Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer. 査読有り国際誌 Open Access

Akatsuka S, Yamashita Y, Ohara H, Liu YT, Izumiya M, Abe K, Ochiai M, Jiang L, Nagai H, Okazaki Y, Murakami H, Sekido Y, Arai E, Kanai Y, Hino O, Takahashi T, Nakagama H, Toyokuni S

PloS one 7 巻 ( 8 ) 頁： e43403 2012年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PLoS ONE

Iron overload has been associated with carcinogenesis in humans. Intraperitoneal administration of ferric nitrilotriacetate initiates a Fenton reaction in renal proximal tubules of rodents that ultimately leads to a high incidence of renal cell carcinoma (RCC) after repeated treatments. We performed high-resolution microarray comparative genomic hybridization to identify characteristics in the genomic profiles of this oxidative stress-induced rat RCCs. The results revealed extensive large-scale genomic alterations with a preference for deletions. Deletions and amplifications were numerous and sometimes fragmented, demonstrating that a Fenton reaction is a cause of such genomic alterations in vivo. Frequency plotting indicated that two of the most commonly altered loci corresponded to a Cdkn2a/2b deletion and a Met amplification. Tumor sizes were proportionally associated with Met expression and/or amplification, and clustering analysis confirmed our results. Furthermore, we developed a procedure to compare whole genomic patterns of the copy number alterations among different species based on chromosomal syntenic relationship. Patterns of the rat RCCs showed the strongest similarity to the human RCCs among five types of human cancers, followed by human malignant mesothelioma, an iron overload-associated cancer. Therefore, an iron-dependent Fenton chemical reaction causes large-scale genomic alterations during carcinogenesis, which may result in distinct genomic profiles. Based on the characteristics of extensive genome alterations in human cancer, our results suggest that this chemical reaction may play a major role during human carcinogenesis. © 2012 Akatsuka et al.

DOI： 10.1371/journal.pone.0043403

過剰鉄と活性酸素を介した発がん機構と予防・治療への展開

豊國伸哉

臨床血液 53 巻 ( 4 ) 頁： 401 - 408 2012年

酸化ストレスによるゲノム変化と発がん

赤塚慎也, 豊國伸哉

実験医学 vol.30 巻頁： 2779 - 2785 2012年

Asbestos surface provides a niche for oxidative modification

NAGAI Hirotaka, ISHIHARA Toshikazu, LEE Wen-Hua, OHARA Hiroki, OKAZAKI Yasumasa, OKAWA Katsuya, TOYOKUNI Shinya

Cancer science 102 巻 ( 12 ) 頁： 2118 - 2125 2011年12月

Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis. 査読有り国際誌

Nagai H, Okazaki Y, Chew SH, Misawa N, Yamashita Y, Akatsuka S, Ishihara T, Yamashita K, Yoshikawa Y, Yasui H, Jiang L, Ohara H, Takahashi T, Ichihara G, Kostarelos K, Miyata Y, Shinohara H, Toyokuni S

Proceedings of the National Academy of Sciences of the United States of America 108 巻 ( 49 ) 頁： E1330-8 - 8 2011年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Proceedings of the National Academy of Sciences of the United States of America

Multiwalled carbon nanotubes (MWCNTs) have the potential for widespread applications in engineering and materials science. However, because of their needle-like shape and high durability, concerns have been raised that MWCNTs may induce asbestos-like pathogenicity. Although recent studies have demonstrated that MWCNTs induce various types of reactivities, the physicochemical features of MWCNTs that determine their cytotoxicity and carcinogenicity in mesothelial cells remain unclear. Here, we showed that the deleterious effects of nonfunctionalized MWCNTs on human mesothelial cells were associated with their diameter-dependent piercing of the cell membrane. Thin MWCNTs (diameter ∼ 50 nm) with high crystallinity showed mesothelial cell membrane piercing and cytotoxicity in vitro and subsequent inflammogenicity and mesotheliomagenicity in vivo. In contrast, thick (diameter ∼ 150 nm) or tangled (diameter ∼ 2-20 nm) MWCNTs were less toxic, inflammogenic, and carcinogenic. Thin and thick MWCNTs similarly affected macrophages. Mesotheliomas induced by MWCNTs shared homozygous deletion of Cdkn2a/2b tumor suppressor genes, similar to mesotheliomas induced by asbestos. Thus, we propose that different degrees of direct mesothelial injury by thin and thick MWCNTs are responsible for the extent of inflammogenicity and carcinogenicity. This work suggests that control of the diameter of MWCNTs could reduce the potential hazard to human health.

DOI： 10.1073/pnas.1110013108

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論文 - 豊國　伸哉