研究者詳細 - 豊國　伸哉

論文 - 豊國　伸哉

分割表示 1,287 件中 41 - 60 件目／全件表示 >>

Analysis of spontaneous pancreatic endocrine tumors in Gcggfp/gfp mice 査読有り国際誌

Hori, M; Maeda, K; Imai, T; Hippo, Y; Toyokuni, S; Hayashi, Y

CANCER SCIENCE 115 巻頁： 181 - 181 2024年3月

Tracking BRCA1 haploinsufficiency focusing mitochondrial metabolism under Fenton reactionbased carcinogenesis 査読有り国際誌

Kong, YY; Mashimo, T; Imaoka, T; Toyokuni, S

CANCER SCIENCE 115 巻頁： 195 - 195 2024年3月

Role of iron, oxygen and ferroptosis in tumor evolutionary biology 査読有り国際誌

Toyokuni, S; Kong, YY; Luo, YG; Zheng, H; Motooka, Y; Imaoka, T; Akatsuka, S

CANCER SCIENCE 115 巻頁： 907 - 907 2024年3月

Involvement of iron-sulphur cofactors in regulation of mammalian THP-1 macrophage iron homeostasis and redox status 査読有り国際誌

Lyu, QY; Toyokuni, S; Kouketsu, Y

CANCER SCIENCE 115 巻頁： 908 - 908 2024年3月

Genomic distribution of 8-oxoguanines in the kidney genome of ferric nitrilotriacetate -treated mice 査読有り国際誌

Akatsuka, S; Toyokuni, S

CANCER SCIENCE 115 巻頁： 1279 - 1279 2024年3月

Effect of aging and PARP inhibitor, olaparib on ovarian function with BRCA1 mutant model rats 査読有り国際誌

Sonehara, R; Motooka, Y; Mashimo, T; Imaoka, T; Kajiyama, H; Toyokuni, S

CANCER SCIENCE 115 巻頁： 170 - 170 2024年3月

BRCA2 germline mutation promotes follicle development and induces diminished ovarian reserve 査読有り国際誌

Tanaka, H; Motooka, Y; Maeda, Y; Mashimo, T; Kajiyama, H; Toyokuni, S

CANCER SCIENCE 115 巻頁： 172 - 172 2024年3月

Epstein-Barr virus lytic gene BNRF1 promotes B-cell lymphomagenesis via IFI27 upregulation. 査読有り国際誌

Sagou K, Sato Y, Okuno Y, Watanabe T, Inagaki T, Motooka Y, Toyokuni S, Murata T, Kiyoi H, Kimura H

PLoS pathogens 20 巻 ( 2 ) 頁： e1011954 2024年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Plos Pathogens

Epstein-Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus that is causally associated with several malignancies. In addition to latent factors, lytic replication contributes to cancer development. In this study, we examined whether the lytic gene BNRF1, which is conserved among gamma-herpesviruses, has an important role in lymphomagenesis. We found that lymphoblastoid cell lines (LCLs) established by BNRF1-knockout EBV exhibited remarkably lower pathogenicity in a mice xenograft model than LCLs produced by wild-type EBV (LCLs-WT). RNA-seq analyses revealed that BNRF1 elicited the expression of interferon-inducible protein 27 (IFI27), which promotes cell proliferation. IFI27 knockdown in LCLs-WT resulted in excessive production of reactive oxygen species, leading to cell death and significantly decreased their pathogenicity in vivo. We also confirmed that IFI27 was upregulated during primary infection in B-cells. Our findings revealed that BNRF1 promoted robust proliferation of the B-cells that were transformed by EBV latent infection via IFI27 upregulation both in vitro and in vivo.

DOI： 10.1371/journal.ppat.1011954

Scopus

PubMed

The blue light hazard and its use on the evaluation of photochemical risk for domestic lighting. An in vivo study 査読有り国際誌 Open Access

Francon, A; Behar-Cohen, F; Torriglia, A

ENVIRONMENT INTERNATIONAL 184 巻 2024年2月

Cold Atmospheric Pressure Plasma-Activated Liquids for Cancer Treatment 査読有り国際誌

Miron C., Hiromasa T., Britun N., Hashizume H., Ishikawa K., Du L., Yamakawa T., Kurebayashi Y., Kondo T., Kondo H., Kajiyama H., Toyokuni S., Mizuno M., Hori M.

Ifmbe Proceedings 111 IFMBE 巻頁： 150 - 162 2024年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Ifmbe Proceedings

Low-temperature plasma (LTP) is a promising tool that can assist in cancer treatment. Plasma-treated liquids have shown a selective cytotoxic effect on cancer cells attributed to reactive species formed in discharge, but this mechanism is not completely understood. In this study, the chemical compounds formed by plasma irradiation of Ringer’s lactate solutions and their effects on non-tumorigenic breast epithelial cells (MCF-10A) and breast cancer cells (MCF-7) were investigated. Among these compounds, glyceric acid increased the cell viability by more than two-fold compared to the control samples for MCF-10A and MCF-7 cells, whereas the tricarballylic acid had a pronounced cytotoxic effect on the cells when incubated with solutions of 0.6 mM to 50 mM concentrations. A good selectivity in killing the cancer cells was observed when the chemical compounds identified in plasma-treated liquids (such as ethyl acetate, glyceric acid, and tricarballylic acid) were used in a mixture solution of a certain concentration. The results show that the LTP-generated chemical compounds have both, stimulatory and inhibitory effects on cell viability, and the best selectivity is achieved only when these compounds are combined in a certain amount and have a synergistic effect, completely killing only the cancer cells.

DOI： 10.1007/978-3-031-62523-7_17

Web of Science

Scopus

Role of Iron, Oxygen and Ferroptosis in Tumor Evolutionary Biology 査読有り国際誌

Toyokuni, S; Kong, Y; Luo, Y; Zheng, H; Motooka, Y; Akatsuka, S

FREE RADICAL BIOLOGY AND MEDICINE 208 巻頁： S112 - S112 2023年11月

Retinal ferroptosis as a critical mechanism for the induction of retinochoroiditis during ocular toxoplasmosis. 査読有り国際誌 Open Access

Yamada K, Tazaki A, Ushio-Watanabe N, Usui Y, Takeda A, Matsunaga M, Suzumura A, Shimizu H, Zheng H, Ariefta NR, Yamamoto M, Hara H, Goto H, Sonoda KH, Nishiguchi KM, Kato M, Nishikawa Y, Toyokuni S, Kaneko H

Redox biology 67 巻頁： 102890 2023年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Redox Biology

Toxoplasmosis is a major infectious disease, affecting approximately one-third of the world's population; its main clinical manifestation, ocular toxoplasmosis (OT), is a severe sight-threatening disease. Nevertheless, the diagnosis of OT is based on clinical findings, which needs improvement, even with biochemical tests, such as polymerase chain reaction and antibody detections. Furthermore, the efficacy of OT-targeted treatment is limited; thus, additional measures for diagnosis and treatments are needed. Here, we for the first time report a significantly reduced iron concentration in the vitreous humor (VH) of human patients infected with OT. To obtain further insights into molecular mechanisms, we established a mouse model of T. gondii infection, in which intravitreally injected tracer 57Fe, was accumulated in the neurosensory retina. T. gondii-infected eyes showed increased lipid peroxidation, reduction of glutathione peroxidase-4 expression and mitochondrial deformity in the photoreceptor as cristae loss. These findings strongly suggest the involvement of ferroptotic process in the photoreceptor of OT. In addition, deferiprone, an FDA-approved iron chelator, reduced the iron uptake but also ameliorated toxoplasma-induced retinochoroiditis by reducing retinal inflammation. In conclusion, the iron levels in the VH could serve as diagnostic markers and iron chelators as potential treatments for OT.

DOI： 10.1016/j.redox.2023.102890

Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression. 査読有り国際誌 Open Access

Van San E, Debruyne AC, Veeckmans G, Tyurina YY, Tyurin VA, Zheng H, Choi SM, Augustyns K, van Loo G, Michalke B, Venkataramani V, Toyokuni S, Bayir H, Vandenabeele P, Hassannia B, Vanden Berghe T

Cell death and differentiation 30 巻 ( 9 ) 頁： 2092 - 2103 2023年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Cell Death and Differentiation

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by central nervous (CNS) demyelination resulting in axonal injury and neurological deficits. Essentially, MS is driven by an auto-amplifying mechanism of inflammation and cell death. Current therapies mainly focus on disease modification by immunosuppression, while no treatment specifically focuses on controlling cell death injury. Here, we report that ferroptosis, an iron-catalyzed mode of regulated cell death (RCD), contributes to MS disease progression. Active and chronic MS lesions and cerebrospinal fluid (CSF) of MS patients revealed several signs of ferroptosis, reflected by the presence of elevated levels of (labile) iron, peroxidized phospholipids and lipid degradation products. Treatment with our candidate lead ferroptosis inhibitor, UAMC-3203, strongly delays relapse and ameliorates disease progression in a preclinical model of relapsing-remitting MS. In conclusion, the results identify ferroptosis as a detrimental and targetable factor in MS. These findings create novel treatment options for MS patients, along with current immunosuppressive strategies. [Figure not available: see fulltext.]

DOI： 10.1038/s41418-023-01195-0

Open Access

Scopus

PubMed

Organic decomposition and synthesis reactions in lactated solution exposed to nonequilibrium atmospheric pressure plasma 査読有り国際誌 Open Access

Liu Y., Ishikawa K., Tanaka H., Miron C., Kondo T., Nakamura K., Mizuno M., Kajiyama H., Toyokuni S., Hori M.

Plasma Processes and Polymers 20 巻 ( 5 ) 2023年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Plasma Processes and Polymers

Lactate is used in the food and pharmaceutical industries and is a crucial intermediate for synthesis. Plasma-activated lactate (PAL) in Ringer's solution was recently shown to have effective antitumor action. Small molecule aldehydes, ketones, and organic acids were produced from lactate during plasma exposure, and five-membered conjugated lactone isomers of furanone (C<inf>5</inf>H<inf>6</inf>O<inf>2</inf>) were detected formed by interactions of lactate or its fragments with •OH, organic radicals, and H<inf>2</inf>O<inf>2</inf>. 2,3-Dimethyl-tartaric acid may be the effective component in PAL for the selective killing of cancer but not normal cells and possible pathways for its synthesis are provided. Aqueous reaction mechanisms are explained, including dehydration, esterification, hydrolysis, and dimerization. This study will help develop novel cancer therapies and further plasma organic chemistry.

DOI： 10.1002/ppap.202200193

Open Access

Web of Science

Scopus

Commentary on "Mechanisms of asbestos-induced carcinogenesis" published in 2009. 査読有り国際誌 Open Access

Toyokuni S

Nagoya journal of medical science 85 巻 ( 1 ) 頁： 13 - 15 2023年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nagoya Journal of Medical Science

Respiratory exposure to asbestos fibers has been associated with diffuse malignant mesothelioma (DMM) in humans. Despite advancements in the molecular analyses of human DMM and the development of animal models, the carcinogenic mechanisms of the disease remain unclear. There are basically three hypotheses regarding the pathogenesis of asbestos-induced DMM, which may be summarized as follows: (1) the “oxidative stress theory” is based on the fact that phagocytic cells that engulf asbestos fibers produce large amounts of free radicals due to their inability to digest the fibers, and epidemiological studies indicating that iron-containing asbestos fibers appear more carcinogenic; (2) the “chromosome tangling theory” postulates that asbestos fibers damage chromosomes when cells divide; and (3) the “theory of adsorption of many specific proteins as well as carcinogenic molecules” states that asbestos fibers in vivo concentrate proteins or chemicals including the components of cigarette smoke. Elucidation of the major mechanisms underlying DMM would be helpful for the development of novel strategies to prevent DMM induction in people who have already been exposed to asbestos

DOI： 10.18999/nagjms.85.1.13

Toward the next century of the Nagoya Journal of Medical Science: message from the Editor-in-chief. 査読有り国際誌 Open Access

Toyokuni S

Nagoya journal of medical science 85 巻 ( 1 ) 頁： 1 - 4 2023年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nagoya Journal of Medical Science

It is my great pleasure and honor as the Editor-in-chief to congratulate the centennial anniversary of the Nagoya Journal of Medical Science in 2023 with all the editorial board members and the technical staffs as well as the authors and the readers. One hundred years are quite a long period, and the persistent publication from a medical school of national university in Japan has not been so easy. Especially, the publication was suspended from 1940 to 1950 due to the World War II.

DOI： 10.18999/nagjms.85.1.1

BRCA1 haploinsufficiency promotes chromosomal amplification under renal carcinogenesis through ferroptosis-resistance 査読有り国際誌

Kong, YY; Akatsuka, S; Motooka, Y; Zheng, H; Shiraki, Y; Mashimo, T; Imaoka, T; Toyokuni, S

CANCER SCIENCE 114 巻頁： 1534 - 1534 2023年2月