研究者詳細 - 豊國　伸哉

論文 - 豊國　伸哉

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The 4-hydroxy-2-nonenal-derived fluorescent pigment 国際誌

Uchida, K, Itakura, K, Oya-Ito, T, Toyokuni, S

FREE RADICAL BIOLOGY AND MEDICINE 27 巻頁： S100 - S100 1999年

The malondialdehyde-derived fluorescent pigment 国際誌

Uchida, K, Sakamoto, S, Itakura, K, Kumazawa, S, Nakayama, T, Toyokuni, S, Osawa, T

FREE RADICAL BIOLOGY AND MEDICINE 27 巻頁： S100 - S100 1999年

Oxidative stress in the human stomach infected with Helicobacter pylori: effect of bacterial eradication 国際誌

Pignatelli B, Li CQ, Bancel B, Toyokuni S, Ohshima H

2ND INTERNATIONAL CONGRESS ON GASTROENTEROLOGICAL CARCINOGENESIS 頁： 39 - 42 1999年

Iron chelators modulate the production of DNA strand breaks and 8-hydroxy-2 '-deoxyguanosine

Toyokuni S, Sagripanti JL

FREE RADICAL RESEARCH 31 巻 ( 2 ) 頁： 123 - 128 1999年

hOGG1 overexpression and high 8-Oxo-2'-deoxyguanosine lyase activity in human colorectal carcinoma 国際誌

Toyokuni, S, Kondo, S, Tanaka, T, Hiai, H, Onodera, H, Imamura, M

FREE RADICAL BIOLOGY AND MEDICINE 27 巻頁： S149 - S149 1999年

Hyperglycemia causes oxidative stress in pancreatic β-cells of GK rats, a model of type 2 diabetes

Ihara Y., Toyokuni S., Uchida K., Odaka H., Tanaka T., Ikeda H., Hiai H., Seino Y., Yamada Y.

Diabetes 48 巻 ( 4 ) 頁： 927 - 932 1999年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Diabetes

Reactive oxygen species are involved in a diversity of biological phenomena such as inflammation, carcinogenesis, aging, and atherosclerosis. We and other investigators have shown that the level of 8-hydroxy-2'- deoxyguanosine (8-OHdG), a marker for oxidative stress, is increased in either the urine or the mononuclear cells of the blood of type 2 diabetic patients. However, the association between type 2 diabetes and oxidative stress in the pancreatic β-cells has not been previously described. We measured the levels of 8-OHdG and 4-hydroxy-2-nonenal (HNE)-modified proteins in the pancreatic β-cells of GK rats, a model of nonobese type 2 diabetes. Quantitative immunohistochemical analyses with specific antibodies revealed higher levels of 8-OHdG and HNE-modified proteins in the pancreatic β-cells of GK rats than in the control Wistar rats, with the levels increasing proportionally with age and fibrosis of the pancreatic islets. We further investigated whether the levels of 8-OHdG and HNE-modified proteins would be modified in the pancreatic β-cells of GK rats fed with 30% sucrose solution or 50 ppm of voglibose (α-glucosidase inhibitor). In the GK rats, the levels of 8-OHdG and HNE-modified proteins, as well as islet fibrosis, were increased by sucrose treatment but reduced by voglibose treatment. These results indicate that the pancreatic β-cells of GK rats are oxidatively stressed, and that chronic hyperglycemia might be responsible for the oxidative stress observed in the pancreatic β-cells.

DOI： 10.2337/diabetes.48.4.927

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Detection of 8-hydroxy-2′-deoxyguanosine by a monoclonal antibody N45.1 and its application 国際誌

Toyokuni, S

ADVANCES IN DNA DAMAGE AND REPAIR 302 巻頁： 395 - 405 1999年

Association between M/L55-polymorphism of paraoxonase enzyme and oxidative DNA damage in patients with type 2 diabetes mellitus and in control subjects

Malin R, Rantalaiho V, Huang XH, Wirta O, Pasternack A, Leinonen JS, Alho H, Jokela H, Koivula T, Tanaka T, Okada K, Ochi H, Toyokuni S, Lehtimaki T

HUMAN GENETICS 105 巻 ( 1-2 ) 頁： 179 - 180 1999年

Oxidative stress in the human stomach infected with <i>Helicobacter pylori</i>:: effect of bacterial eradication 国際誌

Pignatelli, B, Li, CQ, Bancel, B, Toyokuni, S, Ohshima, H

2ND INTERNATIONAL CONGRESS ON GASTROENTEROLOGICAL CARCINOGENESIS 頁： 39 - 42 1999年

卵巣粘液性腫瘍の術中腫瘍捺印細胞像の検討 : 境界悪性例を中心に

清水恵子, 小椋聖子, 村田匡好, 高尾由美, 豊國伸哉, 桜井幹己

日本臨床細胞学会雑誌 37 巻 ( 6 ) 頁： 583 - 590 1998年11月

卵巣粘液性腫瘍の術中腫瘍捺印細胞像の検討 : 境界悪性例を中心に

清水恵子, 小椋聖子, 村田匡好, 高尾由美, 豊國伸哉, 桜井幹己

日本臨床細胞学会雑誌 37 巻 ( 6 ) 頁： 583 - 590 1998年11月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：特定非営利活動法人日本臨床細胞学会

1990年〜1997年迄に術中腫瘍捺印細胞診が施行された卵巣粘液性腫瘍は34例で,良性が16例,境界悪性が12例,悪性が6例であった.術中腫瘍捺印細胞診の正診率は,良性と悪性に関しては100%であったが,境界悪性では75%で誤判定例は全て良性と判定していた.著者等は境界悪性例を中心とした細胞像と,誤判定を防ぐための新しい圧挫標本の併用について検討した.境界悪性腫瘍の細胞像の特徴は,背景が比較的綺麗で,良性例に比べて重積性が増し,乳頭状の集団やボール状の集団が出現していることであった.個々の細胞異型に関しては,良性例に比べてN/C比の増大や,核クロマチン増量,核小体の肥大が部分的に観察されるものの著明ではなく,悪性例とは区別が可能と思われた.良性と誤判定した例は,上皮性成分の出現数の少なさがその最大の原因と思われ,圧挫標本の作製を加えることにより正診率の向上が期待できるものと思われた

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Improvement in hepatic lipid peroxidation in patients with complete response to interferon-α treatment for chronic hepatitis C. 国際誌

Kageyama, F; Kobayashi, Y; Kawasaki, T; Toyokuni, S; Uchida, K; Nakamura, H

HEPATOLOGY 28 巻 ( 4 ) 頁： 250A - 250A 1998年10月

Role of cytochrome P450 isoforms and free radicals in endotoxemic liver injury.

Minamiyama, Y; Takemura, S; Imaoka, S; Toyokuni, S; Funae, Y; Kinoshita, H; Inoue, M

HEPATOLOGY 28 巻 ( 4 ) 頁： 251A - 251A 1998年10月

Role of cytochrome P450 isoforms and free radicals in endotoxemic liver injury. 査読有り

Minamiyama Y, Takemura S, Imaoka S, Toyokuni S, Funae Y, Kinoshita H, Inoue M

HEPATOLOGY 28 巻 ( 4 ) 頁： 251A - 251A 1998年10月

Improvement in hepatic lipid peroxidation in patients with complete response to interferon-alpha treatment for chronic hepatitis C. 査読有り国際誌

Kageyama F, Kobayashi Y, Kawasaki T, Toyokuni S, Uchida K, Nakamura H

HEPATOLOGY 28 巻 ( 4 ) 頁： 250A - 250A 1998年10月

Improvement in hepatic lipid peroxidation in patients with complete response to interferon-α treatment for chronic hepatitis C. 国際誌

Kageyama, F, Kobayashi, Y, Kawasaki, T, Toyokuni, S, Uchida, K, Nakamura, H

HEPATOLOGY 28 巻 ( 4 ) 頁： 250A - 250A 1998年10月

Heat shock preconditioning ameliorates liver injury following normothermic ischemia-reperfusion in steatotic rat livers

Yamagami K, Yamamoto Y, Kume M, Kimoto S, Yamamoto H, Ozaki N, Yamamoto M, Shimahara Y, Toyokuni S, Yamaoka Y

JOURNAL OF SURGICAL RESEARCH 79 巻 ( 1 ) 頁： 47 - 53 1998年9月

Heat shock preconditioning ameliorates liver injury following normothermic ischemia-Reperfusion in steatotic rat livers

Yamagami K., Yamamoto Y., Kume M., Kimoto S., Yamamoto H., Ozaki N., Yamamoto M., Shimahara Y., Toyokuni S., Yamaoka Y.

Journal of Surgical Research 79 巻 ( 1 ) 頁： 47 - 53 1998年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Surgical Research

The decreased tolerance of steatotic livers to warm ischemia complicates liver surgery. The efficacy of heat shock preconditioning in steatotic livers to lessen ischemia-reperfusion injury was studied in rats. Steatotic liver was produced in Lewis rats with a choline-deficient diet. Rats with steatotic livers were divided into a heat shock preconditioned group (group HS) and a control group (group C). All rats received 45 min of hepatic warm ischemia. Survival rates and changes in biochemical and histological parameters were compared in both groups. Heat shock protein 72 (HSP72) was produced only in group HS. The 7-day survival of the rats after warm ischemic intervention was significantly better in group HS (13/15) than in group C (5/15) (P < 0.01). The concentration of ATP in liver tissue (n = 10, P < 0.01) and serum levels of aspartate aminotransferase (n = 10, P < 0.05), alanine aminotransferase (n = 10, P < 0.01), and lactic dehydrogenase (n = 10, P < 0.01) at 40 min reperfusion were also significantly better in group HS than in group C. Histological examination at 40 min reperfusion showed severe sinusoidal congestion, hepatocyte necrosis, and increased positivity to 4-hydroxy-2- nonenal-modified proteins in group C livers; these signs were markedly suppressed in group HS livers. The data indicate that heat shock preconditioning provides the steatotic rat liver with significant tolerance to warm ischemia-reperfusion injury.

DOI： 10.1006/jsre.1998.5403

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CiNii Research

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Development of High-grade Renal Cell Carcinomas in Rats Independently of Somatic Mutations in the Tsc2 and VHL Tumor Suppressor Genes

TOYOKUNI Shinya, OKADA Kunihiko, KONDO Shohei, NISHIOKA Hiroaki, TANAKA Tomoyuki, NISHIYAMA Yasuyuki, HINO Okio, HIAI Hiroshi

Japanese journal of cancer research : gann 89 巻 ( 8 ) 頁： 814 - 820 1998年8月

Development of High-grade Renal Cell Carcinomas in Rats Independently of Somatic Mutations in the Tsc2 and VHL Tumor Suppressor Genes 国際誌

TOYOKUNI Shinya, OKADA Kunihiko, KONDO Shohei, NISHIOKA Hiroaki, TANAKA Tomoyuki, NISHIYAMA Yasuyuki, HINO Okio, HIAI Hiroshi

Japanese journal of cancer research : gann 89 巻 ( 8 ) 頁： 814 - 820 1998年8月

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