研究者詳細 - 豊國　伸哉

論文 - 豊國　伸哉

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Angiotensin II, oxidative stress, and extracellular matrix degradation during transition to LV failure in rats with hypertension. 査読有り

Takenaka H, Kihara Y, Iwanaga Y, Onozawa Y, Toyokuni S, Kita T.

J. Mol. Cell. Cardiol. 41 巻頁： 989-997 2007年

Leukemia inhibitory factor enhances formation of germ cell colonies in neonatal mouse testis culture.

Kanatsu-Shinohara M, Inoue K, Ogonuki N, Miki H, Yoshida S, Toyokuni S, Lee J, Ogura A and Shinohara T.

Biol. Reprod. 76 巻頁： 55-62 2007年

Adult pancreatic islets require differential pax6 gene dosage. 査読有り

Hamasaki A, Yamada Y, Kurose T, Ban N, Nagashima K, Takahashi A, Fujimoto S, Shimono D, Fujiwara M, Toyokuni S, Seino Y and Inagaki N.

Biochem. Biophys. Res. Commun. 353 巻頁： 40-46 2007年

Adenovirus-mediated gene delivery into mouse spermatogonial stem cells. 査読有り

Takehashi M, Kanatsu-Shinohara M, Inoue K, Ogonuki N, Miki H, Toyokuni S, Ogura A, and Shinohara T.

Proc. Natl. Acad. Sci. USA 104 巻頁： 2596-2601 2007年

Pathological investigation of oxidative stress in the post-genomic era. 招待有り査読有り

Toyokuni S and Akatsuka S.

Pathol. Int. 57 巻頁： 461-473 2007年

Overexpressin of a transcription factor LYL-1 induces T- and B-cell lymphoma in mice. 査読有り

Zhong Y, Li J, Hiai H, Toyokuni S* and Yamada Y* (*corresponding author).

Oncogene 26 巻頁： 6937-6947 2007年

ARMET is a soluble ER protein induced by the unfolded protein response via ERSE-II element. 査読有り

Mizobuchi N, Hoseki J, Kubota H, Toyokuni S, Nozaki J, Naitoh M, Koizumi A and Nagata K.

Cell Struct. Funct. 32 巻頁： 41-50 2007年

Akt mediates self-renewal division of mouse spermatogonial stem cells. 査読有り

Lee J, Kanatsu-Shinohara M, Inoue K, Ogonuki N, Miki H, Toyokuni S, Kimura T, Nakano T, Ogura A and Shinohara T.

Development 134 巻頁： 1853-1859 2007年

Association of microRNA-34a overexpression with proliferation is cell type-dependent. 査読有り

Dutta KK, Zhong Y, Liu YT, Yamada T, Akatsuka S, Hu Q, Yoshihara M, Ohara H, Takehashi M, Shinohara T, Masutani H, Onuki J and Toyokuni S.

Cancer Sci. 98 巻頁： 1845-1852 2007年

FasL expression in hepatic antigen-presenting cells and phagocytosis of apoptotic T cells by FasL+ Kupffer cells are indicators of rejection activity in human liver allografts. 査読有り

Miyagawa-Hayashino A, Tsuruyama T, Egawa H, Haga H, Sakashita H, Okuno T, Toyokuni S, Tamaki K, Yamabe H, Manabe T and Uemoto S.

Am J. Pathol. 171 巻頁： 1499-1508 2007年

Production of knockout mice by gene targeting in multipotent germline stem cells. 査読有り

Takehashi M, Kanatsu-Shinohara M, Miki H, Lee J, Kazuki Y, Inoue K, Ogonuki N, Toyokuni S, Oshimura M, Ogura A and Shinohara T.

Dev. Biol. 312 巻頁： 344-352 2007年

Analysis of genes associated with karyo-megalic cells in rat kidney after ferric nitilotriacetate treatment 国際誌

Lee, WH; Toyokuni, S

FREE RADICAL BIOLOGY AND MEDICINE 43 巻頁： S24 - S24 2007年

ARMET is a soluble ER protein induced by the unfolded protein response via ERSE-II element.

Mizobuchi N, Hoseki J, Kubota H, Toyokuni S, Nozaki J, Naitoh M, Koizumi A, Nagata K

Cell structure and function 32 巻 ( 1 ) 頁： 41 - 50 2007年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Cell Structure and Function

Arginine rich, mutated in early stage of tumors (ARMET) was first identified as a human gene highly mutated in a variety of cancers. However, little is known about the characteristics of the ARMET protein and its expression. We identified ARMET as a gene upregulated by endoplasmic reticulum (ER) stress. Here, we show that the mouse homologue of ARMET is an 18-kDa soluble ER protein that is mature after cleavage of a signal sequence and has four intramolecular disulfide bonds, including two in CXXC sequences. ER stress stimulated ARMET expression, and the expression patterns of ARMET mRNA and protein in mouse tissues were similar to those of Grp78, an Hsp70-family protein required for quality control of proteins in the ER. A reporter gene assay using a mouse ARMET promoter revealed that the unfolded protein response of the ARMET gene is regulated by an ERSE-II element whose sequence is identical to that of the HERP gene. ARMET is the second fully characterized ERSE-II-dependent gene and likely contributes to quality control of proteins in the ER. © 2007 by Japan Society for Cell Biology.

DOI： 10.1247/csf.07001

Scopus

PubMed

CiNii Research

Chronic oxidative stress causes amplification and overexpresson of ptprzl protein tyrosine phosphatase to activate beta-catenin pathway

Liu, Y; Toyokuni, S

FREE RADICAL BIOLOGY AND MEDICINE 43 巻頁： S154 - S155 2007年

Visualization and characterization of UVB-induced reactive oxygen species in a human skin equivalent model. 査読有り

Hakozaki T, Date A, Yoshii T, Toyokuni S, Yasui H, Sakurai H

J. Dermatol. Res. 300 (Supplement 1) 巻頁： S51-56 2007年

Oxidative stress is related to formation of Antoni B pattern and eosinophilic hyaline droplets in schwannoma. 査読有り

Yokoo H, Oishi T, Isoda, K, Nakazato Y, Toyokuni S

Neuropathology 27 巻頁： 237-244 2007年

ARMET is a soluble ER protein induced by the unfolded protein response via ERSE-II element 査読有り

Naomi Mizobuchi, Jun Hoseki, Hiroshi Kubota, Shinya Toyokuni, Jun-ichi Nozaki, Motoko Naitoh, Akio Koizumi, Kazuhiro Nagata

CELL STRUCTURE AND FUNCTION 32 巻 ( 1 ) 頁： 41 - 50 2007年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC CELL BIOLOGY

Arginine rich, mutated in early stage of tumors ( ARMET) was first identified as a human gene highly mutated in a variety of cancers. However, little is known about the characteristics of the ARMET protein and its expression. We identified ARMET as a gene upregulated by endoplasmic reticulum ( ER) stress. Here, we show that the mouse homologue of ARMET is an 18- kDa soluble ER protein that is mature after cleavage of a signal sequence and has four intramolecular disulfide bonds, including two in CXXC sequences. ER stress stimulated ARMET expression, and the expression patterns of ARMET mRNA and protein in mouse tissues were similar to those of Grp78, an Hsp70- family protein required for quality control of proteins in the ER. A reporter gene assay using a mouse ARMET promoter revealed that the unfolded protein response of the ARMET gene is regulated by an ERSE- II element whose sequence is identical to that of the HERP gene. ARMET is the second fully characterized ERSE- II- dependent gene and likely contributes to quality control of proteins in the ER.

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Angiotensin II, oxidative stress, and extracellular matrix degradation during transition to LV failure in rats with hypertension. 査読有り

Takenaka H, Kihara Y, Iwanaga Y, Onozawa Y, Toyokuni S, Kita T

J. Mol. Cell. Cardiol. 41 巻頁： 989-997 - 997 2007年

ARMET is a soluble ER protein induced by the unfolded protein response via ERSE-II element

Mizobuchi Naomi, Hoseki Jun, Kubota Hiroshi, Toyokuni Shinya, Nozaki Jun-ichi, Naitoh Motoko, Koizumi Akio, Nagata Kazuhiro

CELL STRUCTURE AND FUNCTION 32 巻 ( 1 ) 頁： 41 - 50 2007年

Novel screening method for ultraviolet protection : Combination of a human skin-equivalent model and 8-hydroxy-2'-deoxyguanosine

TOYOKUNI Shinya, YASUI Hiroyuki, DATE Akira, HAKOZAKI Tomohiro, AKATSUKA Shinya, KOHDA Haruyasu, YOSHII Takashi, SAKURAI Hiromu

Pathology international 56 巻 ( 12 ) 頁： 760 - 762 2006年12月

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論文 - 豊國　伸哉