研究者詳細 - 豊國　伸哉

論文 - 豊國　伸哉

分割表示 1,276 件中 61 - 80 件目／全件表示 >>

The differences between cigarette smoke and electronic cigarette smoke in inducing oxidative stress 査読有り国際誌

Lyu, QY; Toyokuni, S

CANCER SCIENCE 113 巻頁： 1652 - 1652 2022年2月

Pathologic findings toward the concept of cancer as ferroptosis-resistance 査読有り国際誌

Toyokuni, S; Zheng, H; Kong, YY; Luo, YG; Motooka, Y

CANCER SCIENCE 113 巻頁： 661 - 661 2022年2月

Iron overload led by genital talc exposure contributes to ovarian carcinogenesis 査読有り国際誌

Motooka, Y; Ito, F; Tashiro, H; Katabuchi, H; Toyokuni, S

CANCER SCIENCE 113 巻頁： 725 - 725 2022年2月

Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation. 査読有り国際誌 Open Access

Omori S, Tsugita M, Hoshikawa Y, Morita M, Ito F, Yamaguchi SI, Xie Q, Noyori O, Yamaguchi T, Takada A, Saitoh T, Toyokuni S, Akiba H, Nagata S, Kinoshita K, Nakayama M

Cell reports 34 巻 ( 6 ) 頁： 108734 - 108734 2021年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Cell Reports

Needle-like multi-walled carbon nanotubes (MWCNTs) are engulfed by macrophages, which cause inflammation and asbestosis-like pathogenesis in rodents; however, how macrophages recognize MWCNTs remains unclear. Omori et al. demonstrate that Tim4 recognizes MWCNTs through aromatic-aromatic interactions and mediates macrophage phagocytosis leading to granulomas.

DOI： 10.1016/j.celrep.2021.108734

Ferroptosis and Oxidative DNA Damage 査読有り国際誌

Toyokuni, S; Yanatori, I

DNA DAMAGE, DNA REPAIR AND DISEASE, VOL. 1 14 巻頁： 140 - 153 2021年

Induction of cancer cell-specific ferroptosis by non-thermal plasma exposure 査読有り国際誌

Okazaki, Y; Toyokuni, S

JAPANESE JOURNAL OF APPLIED PHYSICS 59 巻 ( 11 ) 2020年11月

Chemical reaction mechanism in non-thermal plasma from the viewpoint of oxidative stress toward clinical cancer applications 査読有り国際共著国際誌

Toyokuni, S; Shi, L; Okazaki, Y; Richardson, DR

FREE RADICAL BIOLOGY AND MEDICINE 100 巻頁： S131 - S131 2016年11月

CANCER AS A FERROTOXIC DISEASE: WHAT WE HAVE LEARNED FROM ANIMAL STUDIES TOWARD ITS PREVENTION 査読有り国際誌

Toyokuni, S, Jiang, L, Okazaki, Y, Akatsuka, S

AMERICAN JOURNAL OF HEMATOLOGY 88 巻 ( 5 ) 頁： E168 - E169 2013年5月

Mysterious link between iron overload and CDKN2A/2B. 国際誌 Open Access

Toyokuni S

Journal of clinical biochemistry and nutrition 48 巻 ( 1 ) 頁： 46 - 9 2011年1月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Clinical Biochemistry and Nutrition

Persistent oxidative stress has been associated with carcinogenesis. Iron overload is considered one such condition that causes oxidative stress. Epidemiological studies support a close link between iron overload and carcinogenesis. Reportedly, regular semiannual phlebotomies reduced cancer risk in an otherwise normal population. More specifically, genetic hemochromatosis, chronic viral hepatitis, ovarian endometriosis and asbestosis induce iron overload, which can lead to hepatocellular carcinoma, ovarian carcinoma or mesothelioma in humans. Through a combination of animal experiments and microarray analyses, homozygous deletion of CDKN2A/2B has been recognized as one of the major target genes involved in iron overload-induced carcinogenesis. CDKN2A/2B are the second most frequently inactivated tumor suppressing genes in human cancers. Currently, when infection is becoming sufficiently controlled worldwide, iron regulation may be the next target for human longevity. ©2011 JCBN.

DOI： 10.3164/jcbn.11-001FR

Asbestos-induced Carcinogenesis is Oxidative Stress-dependent 査読有り国際誌

Toyokuni, S; Jiang, L; Nagai, H; Ohara, H; Okazaki, Y; Akatsuka, S; Yamashita, Y

FREE RADICAL BIOLOGY AND MEDICINE 49 巻頁： S72 - S72 2010年

Spaciotemporal alteration of 8-hydroxy-2'-deoxyguanosine levels in cardiomyocytes after myocardial infarction in rats. 査読有り国際誌 Open Access

Miwa S, Toyokuni S, Nishina T, Nomoto T, Hiroyasu M, Nishimura K, Komeda M

Free radical research 36 巻 ( 8 ) 頁： 853 - 8 2002年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Free Radical Research

Temporary or persistent heart failure is one of the major complications after myocardial infarction (MI). In order to elucidate the pathogenesis of MI, we studied the spaciotemporal alteration of 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels in cardiomyocytes in a rat model of ligation of the left anterior descending branch of the coronary artery. The lethality in this model was 18%. Hearts were dissected at 0, 3, 6, 12, 24, 48h, and 1, 2, 4, 6 weeks after the operation. The cardiac level of 8-OHdG was evaluated biochemically as well as by immunohistochemistry with monoclonal antibody N45.1. Three to 6h after ligation, the 8-OHdG levels were increased in the cardiomyocytes of MI (six-fold) and peri-MI (four-fold) areas. After 24h, the myocardium in the MI area was necrotized, and thereafter the 8-OHdG level decreased. 8-OHdG levels in the myocardium of peri-MI areas returned once to a normal level, but were significantly increased at 2-4 weeks along with the appearance of apoptotic cardiomyocytes in this area. The heart after MI has been generally considered as clinically stable after four weeks. However, cardiomyocytes near the infarcted area were oxidatively stressed even after four weeks when the affected lesion was extensive. The present data support the use of supplementary antioxidant therapies to save functional myocardium after MI. (213 words).

DOI： 10.1081/1071576021000005285

Endogenous formation of protein adducts with carcinogenic aldehydes - Implications for oxidative stress 査読有り国際誌

Ichihashi K, Osawa T, Toyokuni S, Uchida K

JOURNAL OF BIOLOGICAL CHEMISTRY 276 巻 ( 26 ) 頁： 23903 - 23913 2001年6月

Antioxidant alpha-tocopherol improves glycemic control of GK rats, a model of type 2 diabetes 査読有り国際誌

Ihara Y, Yamada Y, Toyokuni S, Ban N, Kuroe A, Seino Y

DIABETES 49 巻頁： A429 - A429 2000年5月

4-hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress - Identification of proteasomes as target molecules 査読有り国際共著国際誌

Okada K, Wangpoengtrakul C, Osawa T, Toyokuni S, Tanaka K, Uchida K

JOURNAL OF BIOLOGICAL CHEMISTRY 274 巻 ( 34 ) 頁： 23787 - 23793 1999年8月

8-hydroxy-2'-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure (vol 107, pg 733, 1996) 査読有り国際誌

Hattori, Y, Nishigori, C, Tanaka, T, Uchida, K, Nikaido, O, Osawa, T, Hiai, H, Imamura, S, Toyokuni, S

JOURNAL OF INVESTIGATIVE DERMATOLOGY 108 巻 ( 2 ) 頁： 237 - 237 1997年2月

ACUTE NEPHROTOXICITY OF A CARCINOGENIC IRON CHELATE - SELECTIVE-INHIBITION OF A PROTEOLYTIC CONVERSION OF ALPHA(2U)-GLOBULIN TO THE KIDNEY FATTY-ACID-BINDING PROTEIN 査読有り国際誌

UCHIDA K, FUKUDA A, KAWAKISHI S, TOYOKUNI S, HIAI H, IKEDA S, HORIO F

FEBS LETTERS 357 巻 ( 2 ) 頁： 165 - 167 1995年1月

Susceptibility of Brca1((L63X/+)) rat to ovarian reserve dissipation by chemotherapeutic agents to breast cancer. 査読有り国際誌 Open Access

Kaseki S, Sonehara R, Motooka Y, Tanaka H, Nakamura T, Osuka S, Akatsuka S, Kajiyama H, Mashimo T, Imaoka T, Toyokuni S

Cancer science 116 巻 ( 4 ) 頁： 1139 - 1152 2025年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Cancer Science

BRCA1 is one of the causative genes for hereditary breast and ovarian cancer syndrome with a high risk of early-onset breast cancer. Whereas olaparib (OLA), an inhibitor of poly-ADP-ribose polymerase, has been applied as adjuvant therapy to those cancer patients, its effect on ovarian reproductive function remains unelucidated. Recently, a rat model (MUT; Brca1(L63X/+) mutation) mimicking a human BRCA1 pathogenic variant has been established. Using this model, we evaluated the effects of OLA on ovarian reproductive function in comparison with the wild-type (WT) rats. MUT showed a significantly reduced number of primordial follicles and subfertility in accordance with aging. Oxidative stress was significantly elevated in the young MUT granulosa cells (GCs) accompanied by increased mTOR but decreased PTEN signals. OLA administration in MUT further decreased primordial follicles, with gene set enrichment analysis, indicating upregulated DNA repair pathways. Furthermore, a combination of OLA and cyclophosphamide (CPA) induced empty primordial follicles, recognized as CPA-induced severe ovarian toxicity. Whereas OLA + CPA caused greater reduction in primordial follicles both in MUT and WT in comparison with CPA alone, MUT ovaries were more susceptible to oxidative stress, potentially depleting primordial follicles via activation of GCs and inducing oocyte death due to accumulated DNA damage by OLA treatment. Our findings in this preclinical model underscore the importance of evaluating ovarian reserve prior to chemotherapy by performing reproductive consultation with female patients with BRCA1 pathogenic variants.

DOI： 10.1111/cas.16412

Heterozygous mutation in BRCA2 induces accelerated age-dependent decline in sperm quality with male subfertility in rats. 査読有り国際誌 Open Access

Motooka Y, Tanaka H, Maeda Y, Katabuchi M, Mashimo T, Toyokuni S

Scientific reports 15 巻 ( 1 ) 頁： 447 - 447 2025年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

Tumor suppressor BRCA2 executes homologous recombination to repair DNA double-strand breaks in collaboration with RAD51, involving exon 11 and 27. Exon 11 constitutes a region where pathogenic variants (PVs) accumulate, and mutations in this region are known to contribute to carcinogenesis. However, the impact of the heterozygous PVs of BRCA2 exon 11 on the life quality beyond cancer risk, including male fertility, remains unclear. Here, we established a rat model with a frameshift on the seventh BRC repeat in Brca2 exon 11 (Brca2+/p.T1942fs), which is homologous to human BRCA2+/p.T1974fs, using CRISPR/Cas9 system. Our analyses revealed that the heterozygous rats with the PV in the BRCA2 exon 11 showed increased DNA double-strand breaks and apoptosis in spermatogonia and spermatocytes, accelerated testicular germ cell loss, and deterioration in sperm quality according with aging, ultimately resulting in early male reproductive dysfunction. Of note, these alterations in testes and sperm, including DNA fragmentation in spermatozoa, were observed from completion of sexual maturation. The present findings suggest that it is crucial to consider not only cancer risk but also potential declines in reproductive capacity in men carrying BRCA2 exon 11 PVs. Further investigation is warranted to determine whether similar traits appear in humans.

DOI： 10.1038/s41598-024-84184-8

細胞外微粒子が鉄代謝と酸化ストレスに及ぼす影響と発がんへの関与査読有り国際誌

本岡大社, 豊國伸哉

大気環境学会誌 60 巻 ( 1 ) 頁： A32 - A38 2025年1月

BRCA2 mutant induce ferroptosis resistance via AKT and promote cell cycle under Fenton reaction-based carcinogenesis 査読有り国際誌

Maeda, Y; Mashimo, T; Toyokuni, S

CANCER SCIENCE 116 巻頁： 875 - 875 2025年1月

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