研究者詳細 - 豊國　伸哉

論文 - 豊國　伸哉

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Ferroptosis resistance is induced by BRCA1 deficiency in asbestos-induced mesothelioma 査読有り国際誌

Luo, YG; Motooka, Y; Akatsuka, S; Mashimo, T; Imaoka, T; Toyokuni, S

CANCER SCIENCE 114 巻頁： 1308 - 1308 2023年2月

Cooperation of Poly(rC)-binding Proteins 1/2 and Glutathione in Ferroptosis Induced by Plasmaactivated Ringer's Lactate 査読有り国際誌

Zheng, H; Jiang, L; Lyu, QY; Akatsuka, S; Motooka, Y; Sekido, Y; Nakamura, K; Tanaka, H; Ishikawa, K; Kajiyama, H; Mizuno, M; Hori, M; Toyokuni, S

CANCER SCIENCE 114 巻頁： 1340 - 1340 2023年2月

Cooperation of Poly(rC)-binding Proteins 1/2 and Glutathione in Ferroptosis Induced by Plasma-activated Ringer's Lactate 査読有り国際誌

Zheng, H; Jiang, L; Lyu, QY; Akatsuka, S; Motooka, Y; Sekido, Y; Nakamura, K; Tanaka, H; Ishikawa, K; Kajiyama, H; Mizuno, M; Hori, M; Toyokuni, S

CANCER SCIENCE 114 巻頁： 749 - 749 2023年2月

Carcinogenic genome toxicity of environmental factors, asbestos and talc in ovary 査読有り国際誌

Motooka, Y; Onimaru, K; Suzuki, HI; Katabuchi, M; Kondoh, E; Tashiro, H; Katabuchi, H; Toyokuni, S

CANCER SCIENCE 114 巻頁： 1085 - 1085 2023年2月

A/J mice exhibit a high susceptibility to ferric nitrilotriacetate-induced RCC through the resistance to ferroptosis 査読有り国際誌

Akatsuka, S; Cheng, Z; Toyokuni, S

CANCER SCIENCE 114 巻頁： 1315 - 1315 2023年2月

Plasma activated Ringer's lactate solution. 査読有り国際誌 Open Access

Tanaka H, Mizuno M, Ishikawa K, Miron C, Okazaki Y, Toyokuni S, Nakamura K, Kajiyama H, Hori M

Free radical research 57 巻 ( 1 ) 頁： 14 - 20 2023年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Free Radical Research

Low-temperature plasma (LTP) has been widely used in life science. Plasma-activated solutions were defined as solutions irradiated with LTP, and water, medium, and Ringer’s solutions have been irradiated with LTP to produce plasma-activated solutions. They contain chemical compounds produced by reactions among LTP, air, and solutions. Reactive oxygen and nitrogen species (RONS) are major components in plasma-activated solutions and recent studies revealed that plasma-activated organic compounds are produced in plasma-activated Ringer’s lactate solution (PAL). Many in vitro and in vivo studies demonstrated that PAL exhibits anti-tumor effects on cancers, and biochemical analyses revealed intracellular molecular mechanisms of cancer cell death by PAL.

DOI： 10.1080/10715762.2023.2182663

Non-thermal plasma elicits ferrous chloride-catalyzed DMPO-OH. 査読有り国際誌

Okazaki Y, Ito N, Tanaka H, Hori M, Toyokuni S

Free radical research 56 巻 ( 9-10 ) 頁： 595 - 606 2022年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Free Radical Research

Non-thermal plasma (NTP) induces the generation of reactive oxygen species (ROS) and reactive nitrogen species, such as hydroxyl radicals (<sup>•</sup>OH), hydrogen peroxide (H<inf>2</inf>O<inf>2</inf>), singlet oxygen, superoxide, ozone, and nitric oxide, at near-physiological temperatures. These molecules promote blood coagulation, wound healing, disinfection, and selective cancer cell death. Based on these evidences, clinical trials of NTP have been conducted for treating chronic wounds and head and neck cancers. Although clinical applications have progressed, the stoichiometric quantification of NTP-induced ROS remains unclear in the liquid phase in the presence of FeCl<inf>2</inf> or FeCl<inf>3</inf> in combination with biocompatible reducing agents, which may modulate the final biological effects of NTP. In this study, we employed electron paramagnetic resonance spectroscopy to quantify ROS using spin-trapping probe, 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and H<inf>2</inf>O<inf>2</inf>, using luminescent probe in the presence of FeCl<inf>2</inf> or FeCl<inf>3</inf>. NTP-induced DMPO-OH levels were elevated 10–100 µM FeCl<inf>2</inf> or 500 and 1000 µM FeCl<inf>3</inf>. NTP-induced DMPO-OH with 10 µM FeCl<inf>2</inf> or FeCl<inf>3</inf> was significantly scavenged by ascorbate, α-tocopherol, dithiothreitol, reduced glutathione, or oxidized glutathione, whereas dehydroascorbate was ineffective in 2 mM DMPO. NTP-induced H<inf>2</inf>O<inf>2</inf> was significantly degraded by 100 µM FeCl<inf>2</inf> and FeCl<inf>3</inf> in an iron-dependent manner. Meanwhile, decomposition of H<inf>2</inf>O<inf>2</inf> by catalase decayed DMPO-OH efficiently in the presence of iron, indicating iron causes DMPO-OH production and degradation simultaneously. These results suggest that NTP-induced DMPO-OH is generated by the H<inf>2</inf>O<inf>2</inf>-consuming, iron-dependent Fenton reaction and ferryl intermediates. The potential iron-mediated ROS production by NTP is also discussed to clarify the interaction between NTP-induced ROS and biomolecules.

DOI： 10.1080/10715762.2022.2157272

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Editorial: Centennial anniversary of vitamin E discovery. 査読有り国際誌 Open Access

Toyokuni S, Noguchi N, Niki E

Free radical biology & medicine 183 巻頁： 125 - 126 2022年4月