研究者詳細 - 豊國　伸哉

論文 - 豊國　伸哉

分割表示 1,236 件中 261 - 280 件目／全件表示 >>

Primary extraskeletal osteosarcoma: a clinicopathological study of 18 cases focusing on MDM2 amplification status. 査読有り国際誌

Yamashita K, Kohashi K, Yamada Y, Nishida Y, Urakawa H, Oda Y, Toyokuni S

Human Pathology 63 巻頁： 63-69 2017年2月

今月の特集2 微量金属元素と生体機能-メタロミクス研究から臨床検査へがんと微量金属元素

伊藤文哉, 豊國伸哉

臨床検査 61 巻 ( 2 ) 頁： 168 - 173 2017年2月

Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma. 査読有り

Chew SH, Okazaki Y, Akatsuka S, Wang S, Jiang L, Ohara Y, Ito F, Saya H, Sekido Y, Toyokuni S.

Free Radical Biology & Medicine 106 巻頁： 91-99 2017年2月

Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma. 査読有り国際誌

Chew SH, Okazaki Y, Akatsuka S, Wang S, Jiang L, Ohara Y, Ito F, Saya H, Sekido Y, Toyokuni S

Free Radical Biology & Medicine 106 巻頁： 91-99 2017年2月

Clinicopathological and Molecular Features of Dedifferentiated Liposarcoma with Ossification: A Comparative Study with Dedifferentiated Liposarcoma without Ossification and Extraskeletal Osteosarcoma

Yamashita Kyoko, Kohashi Kenichi, Yamada Yuichi, Oda Yoshinao, Toyokuni Shinya

MODERN PATHOLOGY 30 巻頁： 27A-27A 2017年2月

Clinicopathological and Molecular Features of Dedifferentiated Liposarcoma with Ossification: A Comparative Study with Dedifferentiated Liposarcoma without Ossification and Extraskeletal Osteosarcoma

Yamashita Kyoko, Kohashi Kenichi, Yamada Yuichi, Oda Yoshinao, Toyokuni Shinya

LABORATORY INVESTIGATION 97 巻頁： 27A - 27A 2017年2月

Clinicopathological and Molecular Features of Dedifferentiated Liposarcoma with Ossification: A Comparative Study with Dedifferentiated Liposarcoma without Ossification and Extraskeletal Osteosarcoma 国際誌

Kyoko Yamashita, Kenichi Kohashi, Yuichi Yamada, Yoshinao Oda, Shinya Toyokuni

LABORATORY INVESTIGATION 97 巻頁： 27A - 27A 2017年2月

Kyoko Yamashita, Kenichi Kohashi, Yuichi Yamada, Yoshinao Oda, Shinya Toyokuni

MODERN PATHOLOGY 30 巻頁： 27A - 27A 2017年2月

Future perspective of strategic non-thermal plasma therapy for cancer treatment.

Kajiyama H, Utsumi F, Nakamura K, Tanaka H, Toyokuni S, Hori M, Kikkawa F

Journal of clinical biochemistry and nutrition 60 巻 ( 1 ) 頁： 33 - 38 2017年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人　日本酸化ストレス学会

The therapeutic effects of non-thermal plasma are expected in the medical fields, including hemostasis, vascularization, prevention of organ adhesion, and cell proliferation. Cancer is an internal enemy arising from normal tissue in the body. The prognosis of metastatic and recurrent cancers is still poor despite advances in medicine. To apply non-thermal plasma in cancer treatment is now on going. The mechanism of the proliferation-inhibitory effect of plasma is reactive nitrogen oxide species/reactive oxygen species production in cells. There are a number of problems to be overcome, such as existence of intrinsic reactive oxygen species/ reactive nitrogen species scavengers and the shallow infiltration of plasma on tumor surface. The current reviews makes referral to the study results of plasma therapy clarified so far, the possibility of its application in the future.

DOI： 10.3164/jcbn.16-65

豊國伸哉

日本毒性学会学術年会 44 巻 ( 0 ) 頁： S11 - S11 2017年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本毒性学会

地球の生命体において鉄は必須であり、高等生物の生命は鉄・酸素・食物によって紡がれる。細胞内で電子の流れを作り制御された化学反応を行うのが酸素の主な役割であるが、体内に取り込まれた酸素の数％は活性酸素・フリーラジカルとなり生体分子に切断・修飾・重合などの傷害を与える。この反応は２価鉄触媒によるFenton反応として1894年より認識されていた。当初放射線の生物作用として理解されたが、1968年SOD発見により活性酸素・フリーラジカルの化学反応が細胞内で常時発生していることが認識されるようになった。発がんは1980年代に始まるがん遺伝子・がん抑制遺伝子の概念の確立により、論理的に理解されるようになった。発がん要因分類として、環境因子・習慣・職業曝露・食習慣・感染症・慢性炎症・遺伝的要因などが列挙され、それを防ぐような手立てが取られてきた。しかし日本では1981年以降、がんが死因の第１位であり右上りである。2014年には英国男性で初めてがんが死因の第１位になった。死因としてのがんの独走は今のがん予防法に大きな疑問を投げかける。私はこれまでの研究より、がんの独走を私たちが酸素と鉄を使用する宿命と理解したい。Wild typeのラットにFenton反応を起こすことでヒトのがんのゲノム変化と酷似したがんが発生することはこの仮説を強く支持する。アスベストや多層カーボンナノチューブによる発がんも異物発がんで基本的には過剰鉄を介するものであり、ラットとヒトで極めて類似したゲノム変化が見られることも注目に値する。これまでの観察により、これらの動物発がんは1ヶ月程度までの初期変化と正比例関係にあることは、毒性学にとって極めて重要であると考えたい。鉄の制御こそが今、がん制御に重要であると考えられる。鉄は一旦、血液内に入ると、体外への積極的な排泄経路はない。50才を過ぎると基礎代謝も低下し、女性は閉経を迎え、鉄が余分になる。私が年２回の全血献血を推奨する所以である。

DOI： 10.14869/toxpt.44.1.0_SL5

CiNii Research

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がんと微量金属元素 (Cancer and trace metal element)

伊藤文哉, 豊國伸哉

臨床検査Journal of clinical laboratory medicine 61 巻 2017年

がんと微量金属元素 (Cancer and trace metal element) 国際誌

伊藤文哉, 豊國伸哉

臨床検査Journal of clinical laboratory medicine 61 巻 2017年

Future perspective of strategic non-thermal plasma therapy for cancer treatment. 査読有り

Kajiyama H, Utsumi F, Nakamura K, Tanaka H, Toyokuni S, Hori M, Kikkawa F.

Journal of Clinical Biochemistry and Nutrition 60 巻 ( 1 ) 頁： 33-38 2016年12月

Future perspective of strategic non-thermal plasma therapy for cancer treatment. 査読有り国際誌

Kajiyama H, Utsumi F, Nakamura K, Tanaka H, Toyokuni S, Hori M, Kikkawa F

Journal of Clinical Biochemistry and Nutrition 60 巻 ( 1 ) 頁： 33-38 2016年12月

Editorial: The cutting edge of zinc biology. 国際誌

Kambe T, Fukada T, Toyokuni S

Archives of biochemistry and biophysics 611 巻頁： 1 - 2 2016年12月

The emerging role of progesterone receptor membrane component 1 (PGRMC1) in cancer biology. 国際誌

Cahill MA, Jazayeri JA, Catalano SM, Toyokuni S, Kovacevic Z, Richardson DR

Biochimica et biophysica acta 1866 巻 ( 2 ) 頁： 339 - 349 2016年12月

Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model 査読有り国際誌

Ushida, T; Kotani, T; Tsuda, H; Imai, K; Nakano, T; Hirako, S; Ito, Y; Li, H; Mano, Y; Wang, J; Miki, R; Yamamoto, E; Iwase, A; Bando, YK; Hirayama, M; Ohno, K; Toyokuni, S; Kikkawa, F

FREE RADICAL BIOLOGY AND MEDICINE 101 巻 ( 16 ) 頁： 524 - 533 2016年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Free Radical Biology and Medicine

Oxidative stress plays an important role in the pathogenesis of preeclampsia. Recently, molecular hydrogen (H2) has been shown to have therapeutic potential in various oxidative stress-related diseases. The aim of this study is to investigate the effect of H2 on preeclampsia. We used the reduced utero-placental perfusion pressure (RUPP) rat model, which has been widely used as a model of preeclampsia. H2 water (HW) was administered orally ad libitum in RUPP rats from gestational day (GD) 12–19, starting 2 days before RUPP procedure. On GD19, mean arterial pressure (MAP) was measured, and samples were collected. Maternal administration of HW significantly decreased MAP, and increased fetal and placental weight in RUPP rats. The increased levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and diacron reactive oxygen metabolites as a biomarker of reactive oxygen species in maternal blood were decreased by HW administration. However, vascular endothelial growth factor level in maternal blood was increased by HW administration. Proteinuria, and histological findings in kidney were improved by HW administration. In addition, the effects of H2 on placental villi were examined by using a trophoblast cell line (BeWo) and villous explants from the placental tissue of women with or without preeclampsia. H2 significantly attenuated hydrogen peroxide-induced sFlt-1 expression, but could not reduce the expression induced by hypoxia in BeWo cells. H2 significantly attenuated sFlt-1 expression in villous explants from women with preeclampsia, but not affected them from normotensive pregnancy. The prophylactic administration of H2 attenuated placental ischemia-induced hypertension, angiogenic imbalance, and oxidative stress. These results support the theory that H2 has a potential benefit in the prevention of preeclampsia.

DOI： 10.1016/j.freeradbiomed.2016.10.491

Preclinical Use of CTGF-Specific Monoclonal Antibody for the Treatment of Malignant Mesothelioma 国際誌

Ohara, Y; Wang, SQ; Jiang, L; Toyokuni, S

FREE RADICAL BIOLOGY AND MEDICINE 100 巻頁： S127 - S127 2016年11月

Urokinase-type plasminogen activator receptor promotes proliferation and invasion with reduced cisplatin sensitivity in malignant mesothelioma. 査読有り国際誌

Wang S, Jiang L, Han Y, Chew SH, Ohara Y, Akatsuka S, Weng L, Kawaguchi K, Fukui T, Sekido Y, Yokoi K, Toyokuni S

Oncotarget 7 巻 ( 43 ) 頁： 69565 - 69578 2016年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oncotarget

Malignant mesothelioma (MM) is a rare neoplasm associated with asbestos exposure. The prognosis of MM is poor because it is aggressive and highly resistant to chemotherapy. Using a rat model of asbestos-induced MM, we found elevated urokinase-type plasminogen activator receptor (uPAR; Plaur) expression in rat tissues, which was associated with poor prognosis. The proliferation, migration and invasion of MM cells were suppressed by uPAR knockdown and increased by overexpression experiments, irrespective of urokinase-type plasminogen activator (uPA; Plau) levels. More importantly, we found that uPAR expression is associated with sensitivity to cisplatin in MM through the PI3K/AKT pathway, which was demonstrated with specific inhibitors, LY294002 and Akti-1/2. uPAR knockdown significantly increased sensitivity to cisplatin whereas its overexpression significantly decreased cisplatin sensitivity. Furthermore, sera and tissues from MM patients showed significantly high uPAR levels, which suggested the pathogenic role of uPAR in the tumor biology of human MM. In conclusion, our findings indicate that uPAR levels are associated with malignant characteristics and cisplatin sensitivity of MM. In addition to the potential use of uPAR as a prognostic marker, the combination of uPAR abrogation and cisplatin may reveal a promising therapeutic approach for MM.

DOI： 10.18632/oncotarget.11829

Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model. 査読有り

Ushida T, Kotani T, Tsuda H, Imai K, Nakano T, Hirako S, Ito Y, Li H, Mano Y, Wang J, Miki R, Yamamoto E, Iwase A, Bando YK, Hirayama M, Ohno K, Toyokuni S, Kikkawa F.

Free Radic Biol Med. pii: S0891-5849 巻 ( 16 ) 頁： 30978-9. 2016年10月

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