Faculty Profiles - TAKAHASHI, Yoshiyuki

Papers - TAKAHASHI, Yoshiyuki

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Late gastroenterological complications in children after allogeneic hematopoietic stem cell transplantation: A retrospective cohort study and a case series of children treated with Kampo medicines Open Access

Nozomu Kawashima, Shinsuke Kataoka, Motoharu Hamada, Eri Nishikawa, Rieko Taniguchi, Atsushi Narita, Hideki Muramatsu, Nobuhiro Nishio, Yoshiyuki Takahashi

Traditional and Kampo Medicine 2023

Language：English Publishing type：Research paper (scientific journal)

Aim: This study aimed to describe children developing late gastrointestinal (GI) complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT), focusing on Kampo medicine. Methods: At the Nagoya University Hospital Department of Pediatrics, 179 consecutive patients underwent allo-HSCT over five years, of whom 167 achieved engraftment and survived at least 100 days post transplant and therefore were included in the study. Results: Thirteen patients (7.8%) developed late GI symptoms. Among these, three had upper GI symptoms, three had lower GI symptoms, while seven had upper/lower GI symptoms. Total parenteral nutrition was administered in 10 (77%) patients for a median of 81 days (range: 20–303). Four (31%) had histologically proven graft-versus-host-disease (GVHD), two (15%) had adverse drug reactions, and one (8%) had a viral infection. All three patients with lower GI symptoms responded to Kampo formulas' warming interior [TM1]. Two patients with upper GI symptoms had epigastric rigidity and responded to Aurantii Fructus Immaturus-based formulas. One patient developed severe cachexia, which was successfully reversed with Kampo medicines. There were no adverse effects due to Kampo medicines. Conclusions: Late GI complications may be a burden on children after allo-HSCT. Kampo medicines may provide a safe and promising therapy to resolve GI symptoms not otherwise specified.

DOI： 10.1002/tkm2.1392

Open Access

Scopus

[Chimeric antigen receptor (CAR) T cells targeting CD19 for acute lymphoblastic leukemia].

Takahashi Y, Nishio N

[Rinsho ketsueki] The Japanese journal of clinical hematology Vol. 64 ( 9 ) page： 1184 - 1191 2023

Ruxolitinib in Pediatric Patients with Treatment-<i>Naive</i> or Steroid-Refractory Acute Graft-Versus-Host Disease: Primary Findings from the Phase I/II REACH4 Study

Locatelli, F; Kang, HJ; Bruno, B; Gandemer, V; Rialland, F; Faraci, M; Takahashi, Y; Koh, K; Bittencourt, H; Cleary, G; Rosko, C; Roussou, P; St Pierre, A; Prahallad, A; Díaz-de-Heredia, C

BLOOD Vol. 140 page： 1376 - 1378 2022.11

Impact of the Coronavirus Disease 2019 Pandemic on the Clinical Features of Pediatric Respiratory Syncytial Virus Infection in Japan Reviewed Open Access

Shoko Ozeki, Jun-ichi Kawada, Daiki Yamashita, Chika Yasufuku, Takuya Akano, Masahiro Kato, Konomi Suzuki, Chihiro Tano, Kazuki Matsumoto, Shu-hei Mizutani, Ayumi Mori, Nobuhiro Nishio, Hiroyuki Kidokoro, Yoshihiro Yasui, Yoshiyuki Takahashi, Yoshiaki Sato, Anna Shiraki, Kazuto Ueda, Shotaro Ando, Noriko Nagai, Tsutomu Aoshima, Michio Suzuki, Tetsuo Kubota, Motomasa Suzuki, Satoru Doi, Daichi Fukumi, Yuichiro Sugiyama, Masafumi Morishita, Naoko Nishimura, Mizuki Takagi, Hirokazu Kurahashi, Yohei Takeuchi, Kenji Kuraishi, Osamu Shinohara, Takashi Kawabe, Nobuhiro Watanabe, Shinji Hasegawa, Taichiro Muto, Shinji Kido, Shinya Hara, Shin Hoshino

Open Forum Infectious Diseases Vol. 9 ( 11 ) page： ofac562 2022.11

Language：English Publishing type：Research paper (scientific journal) Publisher：Oxford University Press (OUP)

Abstract

Background

Mitigation measures implemented during the coronavirus disease 2019 (COVID-19) pandemic remarkably reduced the incidence of infectious diseases among children. However, a re-emergence of respiratory syncytial virus (RSV) infection was observed in 2021 in Japan. We compared the clinical characteristics of hospitalized patients with RSV infection before and during COVID-19.

Methods

We retrospectively enrolled children aged &lt;6 years who were hospitalized with RSV infection in 18 hospitals and compared their clinical characteristics before (January 2019 to April 2020, 1675 patients) and during COVID-19 (September 2020 to December 2021, 1297 patients).

Results

The mean age of patients with RSV infection was significantly higher during COVID-19 than before (17.4 vs 13.7 months, P &lt; .001). Compared with before COVID-19, a 2.6-fold increase in RSV cases in the 2–5 years age group was observed from sentinel surveillance during COVID-19, whereas a 1.2-fold increase was noted in the same age group among hospitalized patients. On average for all patients, consolidation shadows obtained on radiography were less frequently observed (26.1 vs 29.6%, P = .04), and reduced respiratory assistance (42.2% vs 48.7%, P &lt; .001) and hospitalization stay (5.7 vs 6.0 days, P &lt; .001) was required in patients with RSV infection during COVID-19.

Conclusions

Coronavirus disease 2019 and social activity restriction caused epidemiological changes in pediatric RSV infections, and a majority of patients with RSV infection aged ≥2 years did not develop severe symptoms requiring hospitalization. The RSV symptoms during the COVID-19 outbreak were equivalent to or milder than in the previous seasons.

DOI： 10.1093/ofid/ofac562

Open Access

Web of Science

PubMed

Other Link： https://academic.oup.com/ofid/article-pdf/9/11/ofac562/47043659/ofac562.pdf

CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY FOLLOWED BY UR-BMT IN TYROSINE KINASE INHIBITOR RESISTANT PEDIATRIC PH1-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA

Imaya, M; Narita, A; Nishio, N; Wakamatsu, M; Taniguchi, R; Kataoka, S; Muramatsu, H; Ichikawa, D; Maeda, N; Takahashi, Y