Faculty Profiles - TAKAHASHI, Yoshiyuki

Papers - TAKAHASHI, Yoshiyuki

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Detection of Subclonal <i>SETBP1</i> and <i>JAK3</i> Mutations in Patients with Juvenile Myelomonocytic Leukemia Using Droplet Digital PCR Open Access

Wakamatsu, M; Muramatsu, H; Murakami, N; Okuno, Y; Kitazawa, H; Kojima, S; Takahashi, Y

BLOOD Vol. 134 2019.11

High Natural Killer Cell Count at Diagnosis Predicts a Good Response to Immunosuppressive Therapy in Aplastic Anemia

Atsushi Narita, Hideki Muramatsu, Yinyan Xu, Motoharu Hamada, Daisuke Ichikawa, Eri Nishikawa, Nozomu Kawashima, Yusuke Okuno, Nobuhiro Nishio, Hirohito Yamazaki, Shinji Nakao, Seiji Kojima, Yoshiyuki Takahashi

BLOOD Vol. 134 2019.11

Utility of Newborn Screening for Severe Combined Immunodeficiency and X-Linked Agammaglobulinemia Using TREC and KREC Assays Open Access

Wakamatsu, M; Muramatsu, H; Kataoka, S; Okuno, Y; Yoshimi, S; Nakajima, Y; Ito, T; Tsuge, I; Kojima, S; Takahashi, Y

BLOOD Vol. 134 2019.11

Phase I Study of Cord Blood Transplantation with Intra-Bone Marrow Injection of Mesenchymal Stem Cells

Goto, T; Murata, M; Nishida, T; Terakura, S; Kamoshita, S; Ishikawa, Y; Ushijima, Y; Adachi, Y; Kato, K; Hirakawa, A; Nishiwaki, S; Nishio, N; Takahashi, Y; Kodera, Y; Matsushita, T; Kiyoi, H

BLOOD Vol. 134 2019.11

Corrigendum to "Frequent intragenic microdeletions of elastin in familial supravalvular aortic stenosis." [Int. J. Cardiol., 274 (2019) 290-295]. Reviewed International journal Open Access

Satoshi Hayano, Yusuke Okuno, Makiko Tsutsumi, Hidehito Inagaki, Yoshie Fukasawa, Hiroki Kurahashi, Seiji Kojima, Yoshiyuki Takahashi, Taichi Kato

International journal of cardiology Vol. 292 page： 283 - 283 2019.10

Prospective randomized trial comparing two doses of rabbit anti-thymocyte globulin in patients with severe aplastic anaemia. Reviewed International journal Open Access

Atsushi Narita, Xiaofan Zhu, Hideki Muramatsu, Xiaojuan Chen, Ye Guo, Wenyu Yang, Jingliao Zhang, Fang Liu, Jun H Jang, Hoon Kook, Hawk Kim, Kensuke Usuki, Hirohito Yamazaki, Yoshiyuki Takahashi, Shinji Nakao, Jong Wook Lee, Seiji Kojima

British journal of haematology Vol. 187 ( 2 ) page： 227 - 237 2019.10

Language：English Publishing type：Research paper (scientific journal)

The treatment of choice for patients with severe aplastic anaemia (SAA) includes immunosuppressive therapy (IST) with anti-thymocyte globulin (ATG) and ciclosporin A. However, the optimal dose for rabbit ATG has yet to be established. We herein report the first prospective, randomized, multicentre study comparing two doses of rabbit ATG in patients with SAA. Patients with SAA who required initial IST in Japan (n = 89), China (n = 85) and Korea (n = 48) were enrolled between May 2012 and October 2017. A 1:1 block randomization was employed for two doses of rabbit ATG. In total, 222 patients were randomized, with 112 patients receiving 2·5 mg/kg and 110 receiving 3·5 mg/kg of rabbit ATG for 5 days. The primary endpoint was the haematological response at day 180. After 6 months, no significant difference in response rates was observed between the 2·5 and 3·5 mg/kg groups (49% vs. 48%, P = 0·894). Overall survival at 3 years was similar between the two groups [85% (95% confidence interval [CI], 76%-91%) vs. 91% (95% CI, 82%-96%); P = 0·107]. The current study revealed no significant differences in the efficacy and safety between the 2·5 and 3·5 mg/kg doses of rabbit ATG in patients with SAA. Trial registration: UMIN000011134.

DOI： 10.1111/bjh.16055

Web of Science

PubMed

Retrospective analysis of children with high-risk acute myeloid leukemia who underwent allogeneic hematopoietic stem cell transplantation following complete remission with initial induction chemotherapy in the AML-05 clinical trial. Reviewed International journal

Nobuyuki Hyakuna, Yoshiko Hashii, Hiroyuki Ishida, Katsutsugu Umeda, Yoshiyuki Takahashi, Masayuki Nagasawa, Hiromasa Yabe, Yozo Nakazawa, Katsuyoshi Koh, Hiroaki Goto, Hiroyuki Fujisaki, Kimikazu Matsumoto, Harumi Kakuda, Michihiro Yano, Akio Tawa, Daisuke Tomizawa, Takashi Taga, Souichi Adachi, Koji Kato

Pediatric blood & cancer Vol. 66 ( 10 ) page： e27875 2019.10

Language：English Publishing type：Research paper (scientific journal)

In the AML-05 clinical trial conducted by the Japanese Pediatric Leukemia/Lymphoma Group from 2006 to 2010, children with high-risk acute myeloid leukemia (HR AML) received allogeneic hematopoietic stem cell transplantation (allo-HSCT) at first complete remission (CR1). The aim of this study was to investigate the impact of allo-HSCT on the outcome of HR AML. Patients with either monosomy 7, 5q-, t(16;21), Ph1, FLT3-ITD, or induction failure after the first course of chemotherapy were eligible for transplant. Of 53 children with HR AML, 51 received allo-HSCT-45 in CR1, five in CR2, and one with non-CR. t(8;21), t(9;11), and t(16;21) abnormalities were identified in eight, five, and four patients, respectively. The stem cell sources varied-bone marrow in 30 patients, peripheral blood in three, and cord blood in 18. The median follow-up was 62 months. The overall survival (OS) rates at 3 years were 73% and 25% for patients who received transplant at CR1 and ≥CR2, respectively. Multivariable analysis showed that patients with chronic graft-versus-host disease (cGVHD) had better OS. This study supports that allo-HSCT is a suitable treatment for HR AML in CR1. The favorable outcome associated with cGVHD indicates that a graft-versus-leukemia effect might be occurring.

DOI： 10.1002/pbc.27875

Web of Science

PubMed

重症複合型免疫不全患児から排泄されたRV1ワクチン株の院内伝播

三浦浩樹, 河村吉紀, 小澤慶, 成田幸太郎, 村松秀城, 高橋義行, 安岡竜平, 井平勝, 吉川哲史

日本小児感染症学会総会・学術集会プログラム・抄録集 Vol. 51回 page： 195 - 195 2019.10

日本のAYA世代のがん対策の方向性を読み解く

栗本景介, 堀部敬三, 園原史訓, 猪川祥邦, 高見秀樹, 林真路, 神田光郎, 小林大介, 田中千恵, 山田豪, 中山吾郎, 小池聖彦, 清水千佳子, 高橋義行, 小寺泰弘

日本癌治療学会学術集会抄録集 Vol. 57回 page： P166 - 5 2019.10

最期の時間を在宅で過ごすことを選んだ高校生の一例予後告知前後の発言に焦点を当てて

佐々木美和, 滝良梨子, 牧田夏美, 萩原沙織, 清水直子, 梶山早苗, 谷口理恵子, 村松秀城, 高橋義行

日本小児血液・がん学会雑誌 Vol. 56 ( 4 ) page： 375 - 375 2019.10

造血幹細胞移植後に心嚢液貯留をきたした3例(Successfully treated three children with pericardial effusion after hematopoietic stem cell transplantation)

Kitazawa Hironobu, Narita Atsushi, Yoshida Taro, Imaya Masayuki, Yamamori Ayako, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Taniguchi Rieko, Hamada Motoharu, Ichikawa Daisuke, Nishikawa Eri, Kawashima Nozomu, Okuno Yusuke, Nishio Nobuhiro, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 56 ( 4 ) page： 258 - 258 2019.10

遺伝性造血不全症候群に対する全エクソーム解析(Whole exome sequencing contributes to genetic diagnosis of IBMFS patients)

Muramatsu Hideki, Hamada Motoharu, Okuno Yusuke, Wakamatsu Manabu, Taniguchi Rieko, Narita Kotaro, Miwata Shunsuke, Kitazawa Hironobu, Ichikawa Daisuke, Nishikawa Eri, Kawashima Nozomu, Narita Atsushi, Nishio Nobuhiro, Kojima Seiji, Ogi Tomoo, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 56 ( 4 ) page： 229 - 229 2019.10

急性リンパ性白血病治療中に薬剤性神経障害により歩行困難となった14歳男児例(A case of a 14-year-old boy who had difficulty walking due to drug-induced neuropathy during T-cell acute lymphocytic leukemia treatment)

Yoshida Taro, Sawamura Aya, Muramatsu Hideki, Imaya Masayuki, Yamamori Ayako, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Kitazawa Hironobu, Taniguchi Rieko, Ichikawa Daisuke, Nishikawa Eri, Hamada Motoharu, Kawashima Nozomu, Narita Atsushi, Nishio Nobuhiro, Kojima Seiji, Nakata Tomohiko, Kidokoro Hiroyuki, Natxume Jun, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 56 ( 4 ) page： 200 - 200 2019.10

小児発熱性好中球減少症における次世代シークエンス病原微生物診断

堀場千尋, 鳥居ゆか, 原雄一郎, 嶋田繭子, 鈴木高子, 武内俊, 奥村俊彦, 川田潤一, 村松秀城, 高橋義行, 荻朋男, 伊藤嘉規

日本小児感染症学会総会・学術集会プログラム・抄録集 Vol. 51回 page： 196 - 196 2019.10

小児悪性固形腫瘍における網羅的な融合遺伝子検出に基づいた遺伝子診断(Genetic diagnosis based on a comprehensive fusion gene analysis of pediatric malignant solid tumors)

Ichikawa Daisuke, Muramatsu Hideki, Okuno Yusuke, Hamada Motoharu, Taniguchi Rieko, Nishikawa Eri, Kawashima Nozomu, Narita Atsushi, Nishio Nobuhiro, Shimoyama Yoshie, Nakaguro Masato, Nakamura Shigeo, Kojima Seiji, Nakazawa Atsuko, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 56 ( 4 ) page： 227 - 227 2019.10

小児がん拠点病院におけるQuality Indicator

藤崎弘之, 小松裕美, 井口晶裕, 笹原洋二, 康勝好, 湯坐有希, 後藤裕明, 高橋義行, 平山雅浩, 滝田順子, 家原知子, 井上雅美, 小阪嘉之, 川口浩史, 田口智章, 木下義晶, 米田光宏, 瀧本哲也, 松本公一

日本小児血液・がん学会雑誌 Vol. 56 ( 4 ) page： 343 - 343 2019.10

SIPOENスコアリングシステムを用いた、転移性高リスク神経芽腫に対するKIRリガンド不一致臍帯血移植の評価(Evaluation of the outcome of KIR-ligand mismatched cord blood transplantation for high risk metastatic neuroblastoma using new SIOPEN risk stratification)

Nishio Nobuhiro, Ichikawa Daisuke, Wakamatsu Manabu, Narita Kotaro, Miwata Shunsuke, Kitazawa Hironobu, Taniguchi Rieko, Hamada Motoharu, Nishikawa Eri, Kawashima Nozomu, Okuno Yusuke, Narita Atsushi, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 56 ( 4 ) page： 266 - 266 2019.10

がん免疫療法のUp to Date PiggyBacトランスポゾン法によるがんに対する遺伝子改変T細胞療法コスト削減の試み

高橋義行

日本癌治療学会学術集会抄録集 Vol. 57回 page： SSY3 - 3 2019.10

ステロイド抵抗性腸管急性移植片対宿主病に対して経口ブデゾニド投与が有効であった2例(Two cases effectively treated with oral budesonide administration for steroid-resistant intestinal acute graft versus host disease)

Yamamori Ayako, Nishikawa Eri, Narita Atsushi, Imaya Masayuki, Wakamatsu Manabu, Yoshida Taro, Miwata Shunsuke, Kitazawa Hironobu, Narita Kotaro, Taniguchi Rieko, Ichikawa Daisuke, Hamada Motoharu, Kawashima Nozomu, Okuno Yusuke, Nishio Nobuhiro, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 56 ( 4 ) page： 207 - 207 2019.10

セリチニブにより部分奏効が得られたALK転座陽性の治療抵抗性神経芽腫の1例(Induction of partial response with ceritinib for a child with chemotherapy-refractory ALK-rearranged neuroblastoma)

Narita Kotaro, Yoshida Taro, Yamamori Ayako, Wakamatsu Manabu, Imaya Masayuki, Miwata Shunsuke, Kitazawa Hironobu, Taniguchi Rieko, Ichikawa Daisuke, Hamada Motoharu, Nishikawa Eri, Nishio Nobuhiro, Okuno Yusuke, Kawashima Nozomu, Narita Atsushi, Muramatsu Hideki, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 56 ( 4 ) page： 264 - 264 2019.10

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<TAKAHASHI, Yoshiyuki>

Papers - TAKAHASHI, Yoshiyuki