Faculty Profiles - TAKAHASHI, Yoshiyuki

Papers - TAKAHASHI, Yoshiyuki

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Respiratory illness and acute flaccid myelitis in the Tokai district in 2018. Reviewed International journal

Akihisa Okumura, Shingo Numoto, Hideyuki Iwayama, Hirokazu Kurahashi, Jun Natsume, Shinji Saitoh, Tetsushi Yoshikawa, Toshiyuki Fukao, Masahiro Hirayama, Yoshiyuki Takahashi

Pediatrics international : official journal of the Japan Pediatric Society Vol. 62 ( 3 ) page： 337 - 340 2020.3

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: An outbreak of acute flaccid myelitis was chronologically correlated with an outbreak of severe respiratory illness in Japan in 2015. We hypothesized that increases in children hospitalized with severe respiratory illnesses might also be associated with increase in acute flaccid myelitis in autumn 2018. METHODS: We explored the temporal correlations between respiratory illness outbreaks and acute flaccid myelitis during autumn season between 2016 and 2018 using questionnaire surveys. One questionnaire explored the monthly numbers of children with acute flaccid myelitis, Guillain-Barré syndrome, and other acute flaccid paralyses. The other questionnaire explored the monthly numbers of children hospitalized with respiratory illnesses associated with wheezing. A correlation between the monthly numbers of children with acute flaccid myelitis and those with respiratory illness was analyzed using the Pearson correlation test. RESULTS: Although the number of patients hospitalized with respiratory illness did not correlate with the number of those admitted with myelitis, increases in children aged 7-12 and 13-19 years requiring intensive care unit admission correlated temporally with an outbreak of acute flaccid myelitis. CONCLUSIONS: An increase in intensive care unit admissions to treat respiratory disease occurred in association with a cluster of acute flaccid myelitis. An increase in the number of intensive care unit admissions due to respiratory illness may be a clue to expect the occurrence of acute flaccid myelitis.

DOI： 10.1111/ped.14128

Web of Science

PubMed

繰り返す胸痛の経過中に突然発症した心室頻拍の1例

三輪剛士, 山本英範, 深澤佳絵, 六鹿雅登, 加藤太一, 高橋義行

日本小児科学会雑誌 Vol. 124 ( 3 ) page： 611 - 612 2020.3

早期よりエトレチナートを投与し効果がみられた道化師様魚鱗癬の1例

近藤真生, 浅田英之, 本部和也, 郷間環, 新井紗記子, 上田一仁, 三浦良介, 呉尚治, 兵藤玲奈, 鈴木俊彦, 伊藤美春, 齊藤明子, 村松友佳子, 佐藤義朗, 山本ひかる, 加藤有一, 杉山裕一郎, 高橋義行, 早川昌弘

日本小児科学会雑誌 Vol. 124 ( 3 ) page： 609 - 610 2020.3

急性弛緩性脊髄炎による左上肢麻痺に対して神経移行術を施行した1例

西尾洋介, 中田智彦, 白木杏奈, 鈴木健史, 川口将宏, 牧祐輝, 田中雅大, 坂口陽子, 成田敦, 山本啓之, 城所博之, 梶田光春, 平田仁, 高橋義行, 夏目淳

日本小児科学会雑誌 Vol. 124 ( 3 ) page： 604 - 604 2020.3

小児がん・白血病治療における最新医療次世代シークエンサーの臨床応用と遺伝子導入T細胞療法

高橋義行

日本小児科学会雑誌 Vol. 124 ( 3 ) page： 582 - 582 2020.3

TREC/KRECキットを用いた新生児マススクリーニング検査法の有用性

若松学, 村松秀城, 片岡伸介, 山森彩子, 今屋雅之, 吉田太郎, 三輪田俊介, 成田幸太郎, 北澤宏展, 濱田太立, 市川大輔, 谷口理恵子, 西川英里, 川島希, 成田敦, 奥野友介, 西尾信博, 中島葉子, 伊藤哲哉, 柘植郁哉, 中村富美子, 酒井好美, 小島勢二, 高橋義行

日本小児科学会雑誌 Vol. 124 ( 3 ) page： 605 - 605 2020.3

Multilineage-differentiating stress enduring cellsの新生児低酸素性虚血性脳症に対する治療効果の検討

鈴木俊彦, 佐藤義朗, 上田一仁, 北瀬悠磨, 呉尚治, 三浦良介, 浅田英之, 兵藤玲奈, 伊藤美春, 齊藤明子, 村松友佳子, 高橋義行, 早川昌弘

日本小児科学会雑誌 Vol. 124 ( 3 ) page： 595 - 596 2020.3

Human herpesvirus-6B infection in pediatric allogenic hematopoietic stem cell transplant patients: Risk factors and encephalitis. Reviewed International journal

Hiroki Miura, Yoshiki Kawamura, Fumihiko Hattori, Makito Tanaka, Kazuko Kudo, Masaru Ihira, Hiroshi Yatsuya, Yoshiyuki Takahashi, Seiji Kojima, Hirotoshi Sakaguchi, Nao Yoshida, Asahito Hama, Tetsushi Yoshikawa

Transplant infectious disease : an official journal of the Transplantation Society Vol. 22 ( 1 ) page： e13203 2020.2

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Human herpesvirus-6B (HHV-6B) infection after allogenic hematopoietic stem cell transplantation (allo-HSCT) is known to be associated with post-transplant limbic encephalitis in adults. Meanwhile, the association between HHV-6B infection and central nervous system complications remains unclear in pediatric allo-HSCT patients. METHODS: In this study, HHV-6B infection was monitored for more than 50 days after HSCT using virus isolation and real-time PCR. Clinical information such as patient background and encephalitis status was collected retrospectively from medical records. Risk factors for HHV-6B infection were determined by the Cox proportional hazards model, and the clinical features of HHV-6B encephalitis in pediatric allo-HSCT patients were elucidated. RESULTS: Human herpesvirus-6B infection was observed in 74 (33.8%) of 219 patients at 3-47 days (median 18, interquartile range 13-20). Risk factors identified in multivariable analysis were hematological malignancy (hazards ratio [HR], 5.0; 95% confidence interval [CI], 2.3/12.5; P < .0001), solid tumor (HR, 4.8; CI, 1.5/16.3; P = .0104), unrelated donor (HR, 2.1; CI, 1.0/4.6; P = .0378), and sex-mismatched donor (HR 1.8; CI, 1.1/3.0; P = .0257). HHV-6B encephalitis occurred in only one of the 219 patients (0.46%); this patient demonstrated the typical clinical course of posterior reversible encephalopathy syndrome. CONCLUSION: Hematological malignancy, solid tumor, unrelated donor, and sex-mismatched donor were significant risk factors for HHV-6B infection after pediatric allo-HSCT. In pediatric allo-HSCT patients, the incidence of HHV-6B encephalitis was low and the clinical features differed from those in adult patients.

DOI： 10.1111/tid.13203

Web of Science

PubMed

Pseudo-sawtooth pattern on amplitude-integrated electroencephalography in neonatal hypoxic-ischemic encephalopathy. International journal Open Access

Masaharu Tanaka, Hiroyuki Kidokoro, Tetsuo Kubota, Tatsuya Fukasawa, Yu Okai, Yoko Sakaguchi, Yuji Ito, Hiroyuki Yamamoto, Atsuko Ohno, Tomohiko Nakata, Tamiko Negoro, Akihisa Okumura, Toru Kato, Kazuyoshi Watanabe, Yoshiyuki Takahashi, Jun Natsume

Pediatric research Vol. 87 ( 3 ) page： 529 - 535 2020.2

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: The objective of this study was to describe a novel amplitude-integrated electroencephalography (aEEG) pattern in infants with hypoxic-ischemic encephalopathy (HIE) and to assess the clinical significance. METHODS: The aEEG traces of infants with HIE who were treated with therapeutic hypothermia (TH) from 2012 to 2017 were analyzed. A pseudo-sawtooth (PST) pattern was defined as a periodic increase of the upper and/or lower margin of the trace on aEEG without showing seizure activities on conventional EEG (CEEG). RESULTS: Of the 46 infants, 6 (13%) had the PST pattern. The PST pattern appeared following a flat trace or a continuous low-voltage pattern and was followed by a burst-suppression pattern. On CEEG, the PST pattern consists of alternating cycles of low-voltage irregular activities and almost flat tracing. The PST pattern was associated with neuroimaging abnormalities and with various degrees of neurodevelopmental outcomes. Positive predictive values of the PST or worse pattern for adverse outcomes were high at 12 h after birth. CONCLUSION: A novel aEEG background pattern in infants with HIE was reported. The PST pattern likely indicates a suppressed background pattern and may be linked to unfavorable outcomes. Further multicenter validation study is needed to clarify its clinical significance.

DOI： 10.1038/s41390-019-0567-5

Web of Science

PubMed

造血幹細胞移植を受けた小児における拡散テンソル画像解析

坂口陽子, 城所博之, 白木杏奈, 鈴木健史, 川口将宏, 牧祐輝, 田中雅大, 山本啓之, 中田智彦, 村松秀城, 高橋義行, 夏目淳

日本小児科学会雑誌 Vol. 124 ( 2 ) page： 290 - 290 2020.2

神経芽腫寛解導入療法における重症呼吸器症状のリスク因子の検討(Severe respiratory symptoms during induction chemotherapy in neuroblastoma)

松井基浩, 山岡祥子, 斎藤雄弥, 横川裕一, 牧本敦, 西川英里, 川島希, 成田敦, 西尾信博, 村松秀城, 高橋義行, 浦島充佳, 湯坐有希

日本小児科学会雑誌 Vol. 124 ( 2 ) page： 294 - 294 2020.2

腫瘍性疾患と鑑別を要したPhlegmonous gastritisの小児例

三輪田俊介, 成田敦, 吉田太郎, 今屋雅之, 山森彩子, 若松学, 成田幸太郎, 北澤宏展, 濱田太立, 市川大輔, 谷口理恵子, 西川英里, 川島希, 奥野友介, 村松秀城, 西尾信博, 小島勢二, 阿部直紀, 岩田直美, 高橋義行

日本小児科学会雑誌 Vol. 124 ( 2 ) page： 333 - 333 2020.2

川崎病症例における血清中微生物メタゲノム解析

鳥居ゆか, 堀場千尋, 早野聡, 加藤太一, 鈴木高子, 川田潤一, 高橋義行, 小島勢二, 伊藤嘉規

日本小児科学会雑誌 Vol. 124 ( 2 ) page： 223 - 223 2020.2

Targetable driver mutations in multicentric reticulohistiocytosis. Reviewed International journal Open Access

Norihiro Murakami, Tomohisa Sakai, Eisuke Arai, Hideki Muramatsu, Daisuke Ichikawa, Shuji Asai, Yoshie Shimoyama, Naoki Ishiguro, Yoshiyuki Takahashi, Yusuke Okuno, Yoshihiro Nishida

Haematologica Vol. 105 ( 2 ) page： E61 - E64 2020.1

A Novel Treatment with Stem Cells from Human Exfoliated Deciduous Teeth for Hypoxic-Ischemic Encephalopathy in Neonatal Rats. Reviewed International journal

Yuma Kitase, Yoshiaki Sato, Kazuto Ueda, Toshihiko Suzuki, Alkisti Mikrogeorgiou, Yuichiro Sugiyama, Kohki Matsubara, Yuka Tsukagoshi Okabe, Shinobu Shimizu, Hitoshi Hirata, Hiroshi Yukawa, Yoshinobu Baba, Masahiro Tsuji, Yoshiyuki Takahashi, Akihito Yamamoto, Masahiro Hayakawa

Stem cells and development Vol. 29 ( 2 ) page： 63 - 74 2020.1

Language：English Publishing type：Research paper (scientific journal)

Recently, cell therapy has been developed as a novel treatment for perinatal hypoxic-ischemic encephalopathy (HIE), which is an important cause of neurological disorder and death, and stem cells from human exfoliated deciduous teeth (SHED) express early markers for mesenchymal and neuroectodermal stem cells. We investigated the treatment effect of SHED for HIE in neonatal rats. Seven-day-old rats underwent ligation of the left carotid artery and were exposed to 8% hypoxic treatment. SHED (1 × 105 cells) were injected via the right external jugular vein 24 h after the insult. The effect of intravenous administration of SHED cells was evaluated neurologically and pathophysiologically. In the evaluation of engraftment using quantum dots 655, only a few SHED were detected in the injured cortex. In the immunohistological evaluation 24 h after injection, the numbers of positive cells of active caspase-3 and anti-4 hydroxynonenal antiserum were lower in the SHED group than in the vehicle group. The number of Iba-1+ cells in the cortex was higher in the SHED group. However, the proportion of M1 microglia (Iba-1+/ED-1+) was significantly decreased, whereas M2 microglia (Iba-1+/CD206+) tended to increase in the SHED group. In the behavioral tests performed 5 months after hypoxic treatment, compared to the vehicle group, the SHED group showed significant elongation of the endurance time in the rotarod treadmill test, significantly ameliorated proportion of using the impaired hand in the cylinder test, significantly lower ratio of right/left front paw area in gait analysis, and significantly higher avoidance rate in the active avoidance test. In the in vitro experiment with cultured neurons exposed to oxygen-glucose deprivation, we confirmed the neuroprotective effect of the condition medium of SHED. These results suggested that intravenous administration of SHED exerted a treatment effect both histologically and functionally, possibly via a paracrine effect.

DOI： 10.1089/scd.2019.0221

Web of Science

PubMed

A Case of a 14-Year-Old Boy who had Difficulty Walking Due to Drug-Induced Neuropathy During T-Cell Acute Lymphocytic Leukemia Treatment

Taro Yoshida, Aya Sawamura, Hideki Muramatsu, Masayuki Imaya, Ayako Yamamori, Manabu Wakamatsu, Shunsuke Miwata, Kotaro Narita, Hironobu Kitazawa, Rieko Taniguchi, Daisuke Ichikawa, Eri Nishikawa, Motoharu Hamada, Nozomu Kawashima, Atsushi Narita, Nobuhiro Nishio, Seiji Kojima, Tomohiko Nakata, Hiroyuki Kidokoro, Jun Natxume, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S30 - S30 2019.12

A CaseWith Dyskeratosis Congenita Achieved Transfusion Independence after Eltrombopag Treatment

Wakamatsu, M; Muramatsu, H; Imaya, M; Yamamori, A; Yoshida, T; Miwata, S; Kitazawa, H; Narita, K; Ichikawa, D; Hamada, M; Taniguchi, R; Kawasima, N; Nishikawa, E; Narita, A; Okuno, Y; Nishio, N; Kojima, S; Takahashi, Y

PEDIATRIC BLOOD & CANCER Vol. 66 page： S46 - S46 2019.12

Clinical and Laboratory Characteristics of Atypical Chronic Myeloid Leukemia and Chronic Myelomonocytic Leukemia in Japanese Children

Hama, A; Ito, M; Hasegawa, D; Nozawa, K; Muramatsu, H; Takahashi, Y; Watanabe, K; Ohara, A; Manabe, A; Kojima, S

PEDIATRIC BLOOD & CANCER Vol. 66 page： S21 - S22 2019.12

An Infant With Hereditary Folate Malabsorption Requiring Differentiation from Acute Megakaryoblastic Leukemia

Eri Nishikawa, Rieko Taniguchi, Tarou Yoshida, Masayuki Imaya, Manabu Wakamatsu, Syunsuke Miwata, Koutarou Narita, Ayako Yamamori, Hironobu Kitazawa, Daisuke Ichikawa, Motoharu Hamada, Nozomu Kawashima, Atsushi Narita, Yusuke Okuno, Hideki Muramatsu, Nobuhiro Nishio, Seiji Kojima, Shimaa Said, Yusuke Tozawa, Masafumi Yamada, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S73 - S73 2019.12

Identification of <i>FANCI</i> Mutation in Fanconi Anemia in Infancy

Urata, T; Imamura, T; Osone, S; Muramatsu, H; Takahashi, Y; Hosoi, H

PEDIATRIC BLOOD & CANCER Vol. 66 page： S44 - S44 2019.12

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Papers - TAKAHASHI, Yoshiyuki