Faculty Profiles - TAKAHASHI, Yoshiyuki

Papers - TAKAHASHI, Yoshiyuki

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先天性および後天性造血不全375例に対するクリニカルシーケンス(Clinical sequencing of 375 patients with inherited and acquired bone marrow failure syndromes)

Muramatsu Hideki, Okuno Yusuke, Yoshida Kenichi, Shiraishi Yuichi, Narita Atsushi, Sakaguchi Hirotoshi, Kawashima Nozomu, Xu Yinyan, Chiba Kenichi, Tanaka Hiroko, Hama Asahito, Sanada Masashi, Takahashi Yoshiyuki, Kanno Hitoshi, Yamaguchi Hiroki, Ohga Shouichi, Manabe Atsushi, Harigae Hideo, Kunishima Shinji, Ishii Eiichi, Kobayashi Masao, Koike Kenichi, Watanabe Kenichiro, Ito Etsuro, Takata Minoru, Yabe Miharu, Miyano Satoru, Ogawa Seishi, Kojima Seiji

臨床血液 Vol. 58 ( 9 ) page： 1519 - 1519 2017.9

Comparison of sperm subpopulation structures in first and second ejaculated semen from Japanese black bulls by a cluster analysis of sperm motility evaluated by a CASA system Reviewed Open Access

Chihiro Kanno, Kentaro Q. Sakamoto, Yojiro Yanagawa, Yoshiyuki Takahashi, Seiji Katagiri, Masashi Nagano

JOURNAL OF VETERINARY MEDICAL SCIENCE Vol. 79 ( 8 ) page： 1359 - 1365 2017.8

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN SOC VET SCI

In the present study, bull sperm in the first and second ejaculates were divided into subpopulations based on their motility characteristics using a cluster analysis of data from computer-assisted sperm motility analysis (CASA). Semen samples were collected from 4 Japanese black bulls. Data from 9,228 motile sperm were classified into 4 clusters; 1) very rapid and progressively motile sperm, 2) rapid and circularly motile sperm with widely moving heads, 3) moderately motile sperm with heads moving frequently in a short length, and 4) poorly motile sperm. The percentage of cluster 1 varied between bulls. The first ejaculates had a higher proportion of cluster 2 and lower proportion of cluster 3 than the second ejaculates.

DOI： 10.1292/jvms.17-0012

Open Access

Web of Science

PubMed

Bone marrow transplantation for children with acquired bone marrow failure

Hama A., Manabe A., Hasegawa D., Nozawa K., Suzuki K., Narita A., Muramatsu H., Takahashi Y., Watanabe K., Ohara A., Ito M., Kojima S.

BONE MARROW TRANSPLANTATION Vol. 52 page： S414 - S414 2017.7

Clinical utility of next-generation sequencing for inherited bone marrow failure syndromes. Reviewed International journal Open Access

Hideki Muramatsu, Yusuke Okuno, Kenichi Yoshida, Yuichi Shiraishi, Sayoko Doisaki, Atsushi Narita, Hirotoshi Sakaguchi, Nozomu Kawashima, Xinan Wang, Yinyan Xu, Kenichi Chiba, Hiroko Tanaka, Asahito Hama, Masashi Sanada, Yoshiyuki Takahashi, Hitoshi Kanno, Hiroki Yamaguchi, Shouichi Ohga, Atsushi Manabe, Hideo Harigae, Shinji Kunishima, Eiichi Ishii, Masao Kobayashi, Kenichi Koike, Kenichiro Watanabe, Etsuro Ito, Minoru Takata, Miharu Yabe, Seishi Ogawa, Satoru Miyano, Seiji Kojima

Genetics in medicine : official journal of the American College of Medical Genetics Vol. 19 ( 7 ) page： 796 - 802 2017.7

Language：English Publishing type：Research paper (scientific journal) Publisher：NATURE PUBLISHING GROUP

PURPOSE: Precise genetic diagnosis of inherited bone marrow failure syndromes (IBMFS), a heterogeneous group of genetic disorders, is challenging but essential for precise clinical decision making. METHODS: We analyzed 121 IBMFS patients using a targeted sequencing covering 184 associated genes and 250 IBMFS patients using whole-exome sequencing (WES). RESULTS: We achieved successful genetic diagnoses for 53 of 121 patients (44%) using targeted sequencing and for 68 of 250 patients (27%) using WES. In the majority of cases (targeted sequencing: 45/53, 85%; WES: 63/68, 93%), the detected variants were concordant with, and therefore supported, the clinical diagnoses. However, in the remaining 13 cases (8 patients by target sequencing and 5 patients by WES), the clinical diagnoses were incompatible with the detected variants. CONCLUSION: Our approach utilizing targeted sequencing and WES achieved satisfactory diagnostic rates and supported the efficacy of massive parallel sequencing as a diagnostic tool for IBMFS.Genet Med advance online publication 19 January 2017.

DOI： 10.1038/gim.2016.197

Web of Science

PubMed

PiggyBac transposon, a non-viral gene transfer system, mediated T cells expressing CD19 chimeric antigen receptor for a 'first in human' clinical trial

Takahashi, Y; Nishio, N; Hamada, M; Tanaka, M; Morita, D; Kawashima, N; Okuno, Y; Narita, A; Muramatsu, H; Hama, A; Kojima, S; Dotti, G; Nakazawa, Y

BONE MARROW TRANSPLANTATION Vol. 52 page： S161 - S162 2017.7

Recurrent MYB rearrangement in blastic plasmacytoid dendritic cell neoplasm

K Suzuki, Y Suzuki, A Hama, H Muramatsu, M Nakatochi, M Gunji, D Ichikawa, M Hamada, R Taniguchi, S Kataoka, N Murakami, D Kojima, Y Sekiya, E Nishikawa, N Kawashima, A Narita, N Nishio, Y Nakazawa, H Iwafuchi, K-i Watanabe, Y Takahashi, M Ito, S Kojima, S Kato, Y Okuno

Leukemia Vol. 31 ( 7 ) page： 1629 - 1633 2017.7

肺高血圧症(PH)をきたしtadalafilで治療した造血幹細胞移植(HSCT)後の3例

深澤佳絵, 早野聡, 沼口敦, 高橋義行, 加藤太一

日本小児循環器学会雑誌 Vol. 33 ( Suppl.1 ) page： s1 - 402 2017.7

PiggyBac transposon, a non-viral gene transfer system, mediated T cells expressing CD19 chimeric antigen receptor for a 'first in human' clinical trial

Takahashi Y, Nishio N, Hamada M, Tanaka M, Morita D, Kawashima N, Okuno Y, Narita A, Muramatsu H, Hama A, Kojima S, Dotti G, Nakazawa Y

BONE MARROW TRANSPLANTATION Vol. 52 page： S161-S162 2017.7

RECURRENT MYB REARRANGEMENT IN BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM

K. Suzuki, Y. Okuno, Y. Suzuki, A. Hama, H. Muramatsu, M. Nakatochi, M. Gunji, D. Ichikawa, M. Hamada, R. Taniguchi, S. Kataoka, N. Murakami, D. Kojima, Y. Sekiya, E. Nishikawa, N. Kawashima, A. Narita, N. Nishio, Y. Nakazawa, H. Iwafuchi, K. Watanabe, M. Ito, S. Kojima, S. Kato, Y. Takahashi

HAEMATOLOGICA Vol. 102 page： 35 - 35 2017.6

Efficacy of neutrophil non-muscle myosin heavy chain-IIA immunofluorescence analysis in determining the pathogenicity of MYH9 variants. Reviewed International journal

Shinji Kunishima, Okuno Yusuke, Hideki Muramatsu, Daiei Kojima, Noriko Nagai, Yoshiyuki Takahashi, Seiji Kojima

Annals of hematology Vol. 96 ( 6 ) page： 1065 - 1066 2017.6

Long-term outcomes of 95 children with moderate aplastic anemia treated with horse antithymocyte globulin and cyclosporine. Reviewed International journal

Eri Nishikawa, Hiroshi Yagasaki, Asahito Hama, Hiromasa Yabe, Akira Ohara, Yoshiyuki Kosaka, Kazuko Kudo, Ryoji Kobayashi, Shouichi Ohga, Akira Morimoto, Ken-Ichiro Watanabe, Nao Yoshida, Hideki Muramatsu, Yoshiyuki Takahashi, Seiji Kojima

Pediatric blood & cancer Vol. 64 ( 5 ) 2017.5

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY

BACKGROUND: Currently, the standard management of moderate aplastic anemia (MAA) has not been well described, although the superiority of the combination of antithymocyte globulin (ATG) and cyclosporine (CyA) over CyA alone has been demonstrated in terms of hematological responses and failure-free survival (FFS). PROCEDURE: We adopted this therapeutic strategy and treated 95 children with MAA who were enrolled in two consecutive prospective studies between October 1992 and August 2009. RESULTS: For these patients, the 6-month response rate was 54.7% (complete response, 13.7%; partial response, 41.1%). There were no statistically significant differences in the overall response rates between the transfusion-dependent (48.8%, n = 41) and transfusion-independent groups (59.3%, n = 54; P = 0.4). Treatment failure was defined as the requirement of salvage treatment, and was observed in 52 patients. The 10-year FFS was 44.0% (95% confidence interval [CI], 32.9%-54.6%). Of the 22 patients who underwent a second immunosuppressive therapy (IST), 12 responded. Forty patients underwent hematopoietic stem cell transplantation as second- or third-line therapy and three died of complications. Consequently, the 10-year overall survival rate was 96.0% (95% CI, 88.0%-98.7%) with a median follow-up period of 103 months (range, 29-221 months). CONCLUSIONS: Although current guidelines recommend only observation for patients with transfusion-independent MAA, the results of our study justify early intervention with ATG and CyA in those patients. A prospective randomized trial is warranted to clarify the risks and benefits of early intervention with IST and observation alone until progression to severe AA in patients with MAA.

DOI： 10.1002/pbc.26305

Web of Science

PubMed

Paroxysmal nonepileptic events in children with epilepsy. Reviewed International journal

Yuji Ito, Hiroyuki Kidokoro, Tamiko Negoro, Masaharu Tanaka, Yu Okai, Yoko Sakaguchi, Chikako Ogawa, Tomoya Takeuchi, Atsuko Ohno, Hiroyuki Yamamoto, Tomohiko Nakata, Satoshi Maesawa, Kazuyoshi Watanabe, Yoshiyuki Takahashi, Jun Natsume

Epilepsy research Vol. 132 page： 59 - 63 2017.5

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE BV

OBJECTIVE: The aim of this study was to clarify the characteristics of paroxysmal nonepileptic events (PNEs) suspected as being epileptic seizures by families of children with epilepsy. METHODS: The video-EEG (vEEG) recordings of habitual paroxysmal events in children with epilepsy at Nagoya University Hospital between October 2006 and January 2016 were reviewed. Based on the doctor's suspicion before the vEEG, the PNEs were divided into two groups that included PNEs suspected as epileptic seizures and PNEs suspected as PNEs. PNEs in the former group were classified based on the suspected seizure type. RESULTS: Of 886 habitual paroxysmal events, vEEG confirmed that 83 events (68 children) were PNEs. The median age of the 68 children was 3.2 years. Concurrent epilepsies included focal epilepsies (n=33), infantile spasms (n=16), and other types (n=19). The most common types of PNEs were sleep myoclonus (n=11), followed by stereotypies (n=9), awake myoclonus (n=8), paroxysmal ocular deviations (PODs, n=8), and tonic posturing (n=8). Even after direct observation or video viewing, the doctors suspected epileptic seizures in all three of the PODs and two of the tonic posturing children. Before the vEEG, however, the accurate visual information led to the speculation that the four psychogenic and two sleep myoclonus events were all PNEs. Myoclonus, stereotypies, and head drops were often misdiagnosed as epileptic spasms, while PODs and tonic posturing were often misdiagnosed as focal seizures with motor components. Additionally, staring and motion arrest during a drowsy state were often misdiagnosed as focal dyscognitive seizures. Seven of eight patients with PODs had epileptic spasms that were concurrent with epileptic seizures. A diffuse cerebral lesion or reduced visual acuity was seen in seven patients with PODs. CONCLUSION: We re-emphasize that vEEG is essential for accurate diagnosis and provides evidence for listing POD in the differential diagnosis of oculomotor paroxysmal events.

DOI： 10.1016/j.eplepsyres.2017.02.009

Web of Science

PubMed

PiggyBac Mediated T Cells Expressing Anti CD19 Chimeric Antigen Receptor for a Clinical Trial

Nobuhiro Nishio, Yozo Nakazawa, Motoharu Hamada, Satoshi Suzuki, Miyuki Tanaka, Daisuke Morita, Nozomu Kawashima, Yusuke Okuno, Atsushi Narita, Asahito Hama, Hideki Muramatsu, Hideki Muramatsu, Seiji Kojima, Yoshiyuki Takahashi

MOLECULAR THERAPY Vol. 25 ( 5 ) page： 291 - 291 2017.5

Germline IKAROS mutation associated with primary immunodeficiency that progressed to T-cell acute lymphoblastic leukemia Reviewed

N. Yoshida, H. Sakaguchi, H. Muramatsu, Y. Okuno, C. Song, S. Dovat, A. Shimada, M. Ozeki, H. Ohnishi, T. Teramoto, T. Fukao, N. Kondo, Y. Takahashi, K. Matsumoto, K. Kato, S. Kojima

LEUKEMIA Vol. 31 ( 5 ) page： 1221 - 1223 2017.5

Early germinal vesicle breakdown is a predictor of high preimplantation developmental competent oocytes in mice Reviewed

Shogo Higaki, Masao Kishi, Keisuke Koyama, Masashi Nagano, Seiji Katagiri, Tatsuyuki Takada, Yoshiyuki Takahashi

ZYGOTE Vol. 25 ( 1 ) page： 41 - 48 2017.2

Language：English Publishing type：Research paper (scientific journal) Publisher：CAMBRIDGE UNIV PRESS

The preselection of highly developmentally competent oocytes for in vitro maturation (IVM) is crucial for improving assisted reproductive technology. Although several intrinsic markers of oocyte quality are known to be closely related to the onset of nuclear maturation (germinal vesicle break down, GVBD), a direct comparison between GVBD timing and oocyte quality has never been reported. In this study, we established a non-invasive oocyte evaluation method based on GVBD timing for preselecting more developmental competent oocytes in mice. Because the O-2 concentration during IVM may affect the nuclear kinetics, all experiments were performed under two distinct O-2 concentrations: 20% and 5% O-2. First, we determined the time course of changes in nuclear maturation and preimplantation developmental competence of in vitro-matured oocytes to estimate GVBD timing in high developmental competent oocytes. Two-thirds of oocytes that underwent GVBD in early IVM seemed to mainly contribute to the blastocyst yield. To confirm this result, we compared the preimplantation developmental competence of the early and late GVBD oocytes. Cleavage and blastocyst formation rates of early GVBD oocytes (80.2% and 52.7% under 20% O-2, respectively, and 67.6% and 47.3% under 5% O-2, respectively) were almost double those of late GVBD oocytes (44.8% and 26.0% under 20% O-2, respectively, and 40.4% and 17.9% under 5% O-2, respectively). With no observable alterations by checking the timing of GVBD in preimplantation developmental competence, oocyte evaluation based on GVBD timing can be used as an efficient and non-invasive preselection method for high developmental competent oocytes.

DOI： 10.1017/S0967199416000290

Web of Science

PubMed

Investigation of a Rotavirus Gastroenteritis Outbreak among Immunosuppressed Patients in a Hospital Setting.

Sugata K, Hull J, Wang H, Foytich K, Moon SS, Takahashi Y, Kojima S, Yoshikawa T, Jiang B

Journal of immunological techniques in infectious diseases Vol. 6 ( 1 ) 2017.1

Clinical utility of next-generation sequencing-based minimal residual disease in paediatric B-cell acute lymphoblastic leukaemia. Reviewed International journal Open Access

Yuko Sekiya, Yinyan Xu, Hideki Muramatsu, Yusuke Okuno, Atsushi Narita, Kyogo Suzuki, Xinan Wang, Nozomu Kawashima, Hirotoshi Sakaguchi, Nao Yoshida, Asahito Hama, Yoshiyuki Takahashi, Koji Kato, Seiji Kojima

British journal of haematology Vol. 176 ( 2 ) page： 248 - 257 2017.1

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

We assessed the clinical utility of next-generation sequencing (NGS)-based monitoring of minimal residual disease (MRD) in a uniformly treated cohort of 79 patients with paediatric B-cell acute lymphoblastic leukaemia. Bone marrow samples were collected at the time of diagnosis, days 33 and 80, pre- (4-5 months) and post- (24 months) maintenance therapy time points, and at relapse. We identified leukaemia-specific CDR3 sequences in 72 of 79 patients (91%) and detected MRD in 59 of 232 samples. Although MRD was detected in 28 of 55 samples (51%) on day 33, the frequencies of MRD detection decreased to 25% (16/65) at day 80, 19% (11/58) at 4-5 months and 7·4% (4/54) at 24 months. In a univariate analysis, positive MRD results on day 80 [relative risk (RR) 95% confidence interval (CI) = 7·438 (2·561-21·6), P < 0·001], at 4-5 months [RR (95% CI) = 10·24 (3·374-31·06), P < 0·001], and at 24 months [RR (95% CI) = 19·26 (4·974-74·59), P < 0·001] exhibited statistically significant associations with inferior leukaemia-free survival; this was confirmed using a Cox proportional hazard model. Our study suggests the promising potential of NGS-MRD for patients with B-cell ALL.

DOI： 10.1111/bjh.14420

Web of Science

PubMed

Allogeneic hematopoietic stem cell transplantation using ATG: prophylaxis and treatment. Reviewed

Nishio N, Takahashi Y, Kojima S

[Rinsho ketsueki] The Japanese journal of clinical hematology Vol. 58 ( 10 ) page： 2104 - 2110 2017

The Measurement of X-ray Fluoroscopy Input-output Characteristics in Angiography System. Reviewed

Hagihara Y, Umehara T, Matsumoto K, Fujita T, Ikeuchi Y, Fujikawa K, Takahashi Y, Kotoura N

Nihon Hoshasen Gijutsu Gakkai zasshi Vol. 73 ( 2 ) page： 96 - 103 2017

*Relapse of leukemia with loss of mismatched HLA due to uniparental disomy following haploidentical hematopoietic stem cell transplantation. Reviewed

Villalobos IB, Takahashi Y, Akatsuka Y, Muramatsu H, Nishio N, Hama A, Yagasaki H, Saji H, Kato M, Ogawa S, Kojima S.

Blood Vol. Epub ahead of print page： Epub ahead of print 2010

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Papers - TAKAHASHI, Yoshiyuki