Faculty Profiles - TAKAHASHI, Yoshiyuki

Papers - TAKAHASHI, Yoshiyuki

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Increased response to granulocyte-macrophage colony-stimulating factor in peripheral blood cells and transient manifestations mimicking juvenile myelomonocytic leukemia in a male patient with NEMO deficiency caused by a deep intronic pathogenic variant of IKBKG. Reviewed Open Access

Ueki M, Hirabayashi S, Honda Y, Takezaki S, Ohata H, Abdrabou SSMA, Sawai S, Terashita Y, Cho Y, Muramatsu H, Izawa K, Yasumi T, Takahashi Y, Yamada M, Manabe A

Immunological medicine Vol. 48 ( 1 ) page： 94 - 101 2025.3

Successful Treatment with Sirolimus of a Patient with a Novel CARD11 Germline Mutation in B-Cell Expansion with Nuclear Factor Kappa B and T-Cell Anergy: Case Report and Literature Review. Reviewed

Nishinosono T, Muramatsu H, Wakamatsu M, Yamashita D, Fukasawa T, Shirakawa Y, Sajiki D, Maemura R, Tsumura Y, Yamamori A, Narita K, Kataoka S, Narita A, Nishio N, Miyajima Y, Takahashi Y

Journal of clinical immunology Vol. 45 ( 1 ) page： 78 2025.2

Real-world Outcomes of Commercial Tisagenlecleucel for Children, Adolescents, and Young Adults With Acute Lymphoblastic Leukemia in Japan. Reviewed Open Access

Kato I, Tomizawa D, Kato M, Hirabayashi S, Manabe A, Irie M, Sasahara Y, Arakawa Y, Koh K, Sakaguchi H, Sugiyama M, Ogawa C, Kamiya T, Saito S, Nakazawa Y, Nishio N, Takahashi Y, Iwai N, Adachi S, Takita J, Miyamura T, Yokoyama S, Oba U, Ueda T, Koga Y, Hiramatsu H

Transplantation and cellular therapy Vol. 31 ( 2 ) page： 86 - 96 2025.2

Cord Blood Transplantation Using Myeloablative Conditioning for Pediatric Advanced Myelodysplastic Syndrome in AMeD Syndrome With a Novel ADH5 Variant. Reviewed Open Access

Morishita Y, Hamada M, Uemura S, Kikuchi H, Hisakawa H, Fujikawa T, Tamura A, Okuno Y, Wakamatsu M, Muramatsu H, Takahashi Y, Hasegawa D, Kosaka Y

Pediatric blood & cancer Vol. 72 ( 2 ) page： e31465 2025.2

Frequency of SARS-CoV-2 antecedent infection in patients with Kawasaki disease. Reviewed

Go K, Kawano Y, Nagai N, Omori D, Morimoto Y, Yamamoto H, Fukasawa Y, Ito Y, Takahashi Y, Kato T

Nagoya journal of medical science Vol. 87 ( 1 ) page： 76 - 83 2025.2

Association between adeno-associated virus 2 and severe acute hepatitis of unknown etiology in Japanese children Reviewed

Ken-ichi Iwata, Yuka Torii, Aiko Sakai, Yuto Fukuda, Kazunori Haruta, Makoto Yamaguchi, Takako Suzuki, Yuri Etani, Yoshiyuki Takahashi, Shuichiro Umetsu, Ayano Inui, Ryo Sumazaki, Jun-ichi Kawada

Journal of Infection and Chemotherapy Vol. 31 ( 1 ) page： 102462 2025.1

Sleep state-dependent development of resting-state functional connectivity during the preterm period. Reviewed

Shiraki A, Kidokoro H, Watanabe H, Taga G, Ushida T, Narita H, Mitsumatsu T, Kumai S, Suzui R, Sawamura F, Ito Y, Yamamoto H, Nakata T, Sato Y, Hayakawa M, Takahashi Y, Natsume J

Sleep Vol. 47 ( 12 ) 2024.12

Ruxolitinib for pediatric patients with treatment-naïve and steroid-refractory acute graft-versus-host disease: the REACH4 study. Reviewed Open Access

Locatelli F, Kang HJ, Bruno B, Gandemer V, Rialland F, Faraci M, Takahashi Y, Koh K, Bittencourt H, Cleary G, Rosko C, Li X, St Pierre A, Prahallad A, Diaz-de-Heredia C

Blood Vol. 144 ( 20 ) page： 2095 - 2106 2024.11

Frequent loss of HLA-B*40:02 from leucocytes in male patients with hepatitis-associated aplastic anaemia. Reviewed Open Access

Katagiri T, Takahashi R, Zaimoku Y, Hosokawa K, Ogawa S, Takahashi Y, Miyamura T, Onishi Y, Koike T, Nishida T, Uchida N, Doki N, Tanaka M, Eto T, Itagaki M, Sawa M, Fukuda T, Onizuka M, Atsuta Y, Nakao S

British journal of haematology Vol. 205 ( 5 ) page： 2084 - 2088 2024.11

A Retrospective Study of Pediatric Patients With Low- or Intermediate-Risk Acute Myeloid Leukemia Who Underwent Allogeneic Hematopoietic Cell Transplantation for the AML-05 Study Conducted by the Japanese Pediatric Leukemia/Lymphoma Study Group. Reviewed Open Access

Hashii Y, Kawaguchi K, Kurakami H, Umeda K, Hasegawa D, Taki T, Hyakuna N, Ishida H, Takahashi Y, Nagasawa M, Yabe H, Yano M, Nakazawa Y, Fujisaki H, Matsumoto K, Yanagimachi M, Yoshida N, Kakuda H, Satou A, Tabuchi K, Tomizawa D, Taga T, Adachi S, Koh K, Kato K

Transplantation and cellular therapy Vol. 30 ( 11 ) page： 1102.e1 - 1102.e12 2024.11

A Japanese retrospective study of non-tuberculous mycobacterial infection in children, adolescents, and young adult patients with hematologic-oncologic diseases. Reviewed

Tsumura Y, Muramatsu H, Tetsuka N, Imaizumi T, Sato K, Inoue K, Motomura Y, Cho Y, Yamashita D, Sajiki D, Maemura R, Yamamori A, Imaya M, Wakamatsu M, Narita K, Kataoka S, Hamada M, Taniguchi R, Nishikawa E, Narita A, Nishio N, Kojima S, Hoshino Y, Takahashi Y

Haematologica Vol. 109 ( 9 ) page： 2988 - 2997 2024.9

High threshold of total developmental quotient at 3 years for follow-up in extremely preterm infants. Reviewed

Maeda T, Tanahashi Y, Asada H, Kidokoro H, Takahashi Y, Sato Y

Early human development Vol. 196 page： 106098 2024.9

Correction: Harmonizing definitions for hematopoietic recovery, graft rejection, graft failure, poor graft function, and donor chimerism in allogeneic hematopoietic cell transplantation: a report on behalf of the EBMT, ASTCT, CIBMTR, and APBMT. Reviewed

Sureda A, Carpenter PA, Bacigalupo A, Bhatt VR, de la Fuente J, Ho A, Kean L, Lee JW, Sánchez-Ortega I, Savani BN, Schetelig J, Stadtmauer EA, Takahashi Y, Atsuta Y, Koreth J, Kröger N, Ljungman P, Okamoto S, Popat U, Soiffer R, Stefanski HE, Kharfan-Dabaja MA

Bone marrow transplantation Vol. 59 ( 9 ) page： 1335 2024.9

Risk factors of bloodstream infection after allogeneic hematopoietic cell transplantation in children/adolescent and young adults. Reviewed Open Access

Sajiki D, Muramatsu H, Wakamatsu M, Yamashita D, Maemura R, Tsumura Y, Imaya M, Yamamori A, Narita K, Kataoka S, Taniguchi R, Narita A, Nishio N, Takahashi Y

PloS one Vol. 19 ( 8 ) page： e0308395 2024.8

Ruxolitinib in treatment-naive or corticosteroid-refractory paediatric patients with chronic graft-versus-host disease (REACH5): interim analysis of a single-arm, multicentre, phase 2 study. Reviewed

Locatelli F, Antmen B, Kang HJ, Koh K, Takahashi Y, Kupesiz A, Dias Matos MGA, Chopra Y, Bhat S, Im HJ, Güngör T, Lu MY, Stefanelli T, Rosko C, St Pierre A, Burock K, Smith Y, Sinclair K, Diaz-de-Heredia C

The Lancet. Haematology Vol. 11 ( 8 ) page： e580 - e592 2024.8

Clinical features of immature leukemias in children. Reviewed

Daichi Sajiki, Nao Yoshida, Hideki Muramatsu, Kimiyoshi Sakaguchi, Naoko Maeda, Norifumi Yokoyama, Yuji Miyajima, Makito Tanaka, Yoshiyuki Takahashi, Asahito Hama

International journal of hematology Vol. 120 ( 1 ) page： 117 - 127 2024.7

Language：English Publishing type：Research paper (scientific journal)

Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL), mixed phenotypic acute leukemia (MPAL), and acute myeloid leukemia with minimal differentiation (AML-M0) all originate from immature hematopoietic progenitor cells and have a poor prognosis. We investigated the clinical characteristics of these immature leukemias in 17 children (ETP-ALL: 8, MPAL: 5, AML-M0: 4) at seven institutions. Clinical and laboratory findings were comparable across disease types. Eleven and six patients received ALL- and AML-oriented induction chemotherapy, with six and four achieving complete remission (CR), respectively. Five additional patients achieved CR after salvage with the other type of chemotherapy. Eight patients received hematopoietic cell transplantation (HCT) in first CR, and six survived without relapse. However, six of seven patients who did not receive HCT during first CR relapsed; all underwent HCT later, and only three survived. The 5-year event-free survival (EFS) and overall survival (OS) rate were 37% and 69%, respectively. Patients who achieved CR after induction chemotherapy and received HCT in first CR had favorable EFS and OS. Notably, all patients who received HCT in first CR survived 5 years after diagnosis. Appropriate induction chemotherapy and HCT in first CR could improve the outcome of immature leukemias.

DOI： 10.1007/s12185-024-03771-7

PubMed

A retrospective analysis of gene fusions and treatment outcomes in pediatric acute megakaryoblastic leukemia without Down syndrome. Reviewed International journal

Kyogo Suzuki, Asahito Hama, Yusuke Okuno, Yinyan Xu, Atsushi Narita, Nao Yoshida, Hideki Muramatsu, Nobuhiro Nishio, Koji Kato, Seiji Kojima, Keon Hee Yoo, Yoshiyuki Takahashi

Haematologica Vol. 109 ( 6 ) page： 1936 - 1940 2024.6

Novel mutation in <i>KIF23</i> causing congenital dyserythropoietic anemia type III in patients who underwent allogeneic hematopoietic stem cell transplantation Reviewed

Tomoko Fujikawa, Suguru Uemura, Daiichiro Hasegawa, Naoya Morisada, Sayaka Nakamura, Aiko Kozaki, Atsuro Saito, Kenji Kishimoto, Toshiaki Ishida, Takeshi Mori, Kimikazu Yakushijin, Yoshio Katayama, Daiki Yamashita, Manabu Wakamatsu, Motoharu Hamada, Hideki Muramatsu, Yoshiyuki Takahashi, Yoshiyuki Kosaka

Pediatric Blood & Cancer Vol. 71 ( 6 ) page： e30736 2024.6

Harmonizing definitions for hematopoietic recovery, graft rejection, graft failure, poor graft function, and donor chimerism in allogeneic hematopoietic cell transplantation: a report on behalf of the EBMT, ASTCT, CIBMTR, and APBMT. Reviewed

Bone marrow transplantation Vol. 59 ( 6 ) page： 832 - 837 2024.6

Integrated proteogenomic analysis for inherited bone marrow failure syndrome. Reviewed International journal

Manabu Wakamatsu, Hideki Muramatsu, Hironori Sato, Masaki Ishikawa, Ryo Konno, Daisuke Nakajima, Motoharu Hamada, Yusuke Okuno, Yusuke Kawashima, Asahito Hama, Masafumi Ito, Hideto Iwafuchi, Yoshiyuki Takahashi, Osamu Ohara

Leukemia Vol. 38 ( 6 ) page： 1256 - 1265 2024.6

Language：English Publishing type：Research paper (scientific journal)

Recent advances in in-depth data-independent acquisition proteomic analysis have enabled comprehensive quantitative analysis of >10,000 proteins. Herein, an integrated proteogenomic analysis for inherited bone marrow failure syndrome (IBMFS) was performed to reveal their biological features and to develop a proteomic-based diagnostic assay in the discovery cohort; dyskeratosis congenita (n = 12), Fanconi anemia (n = 11), Diamond-Blackfan anemia (DBA, n = 9), Shwachman-Diamond syndrome (SDS, n = 6), ADH5/ALDH2 deficiency (n = 4), and other IBMFS (n = 18). Unsupervised proteomic clustering identified eight independent clusters (C1-C8), with the ribosomal pathway specifically downregulated in C1 and C2, enriched for DBA and SDS, respectively. Six patients with SDS had significantly decreased SBDS protein expression, with two of these not diagnosed by DNA sequencing alone. Four patients with ADH5/ALDH2 deficiency showed significantly reduced ADH5 protein expression. To perform a large-scale rapid IBMFS screening, targeted proteomic analysis was performed on 417 samples from patients with IBMFS-related hematological disorders (n = 390) and healthy controls (n = 27). SBDS and ADH5 protein expressions were significantly reduced in SDS and ADH5/ALDH2 deficiency, respectively. The clinical application of this first integrated proteogenomic analysis would be useful for the diagnosis and screening of IBMFS, where appropriate clinical screening tests are lacking.

DOI： 10.1038/s41375-024-02263-1

PubMed

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Papers - TAKAHASHI, Yoshiyuki