Faculty Profiles - TAKAHASHI, Yoshiyuki

Papers - TAKAHASHI, Yoshiyuki

Division display 81 - 100 of about 483 ／ All the affair displays >>

Macromolecular organic matter in samples of the asteroid (162173) Ryugu. Open Access

Yabuta H, Cody GD, Engrand C, Kebukawa Y, De Gregorio B, Bonal L, Remusat L, Stroud R, Quirico E, Nittler L, Hashiguchi M, Komatsu M, Okumura T, Mathurin J, Dartois E, Duprat J, Takahashi Y, Takeichi Y, Kilcoyne D, Yamashita S, Dazzi A, Deniset-Besseau A, Sandford S, Martins Z, Tamenori Y, Ohigashi T, Suga H, Wakabayashi D, Verdier-Paoletti M, Mostefaoui S, Montagnac G, Barosch J, Kamide K, Shigenaka M, Bejach L, Matsumoto M, Enokido Y, Noguchi T, Yurimoto H, Nakamura T, Okazaki R, Naraoka H, Sakamoto K, Connolly HC Jr, Lauretta DS, Abe M, Okada T, Yada T, Nishimura M, Yogata K, Nakato A, Yoshitake M, Iwamae A, Furuya S, Hatakeda K, Miyazaki A, Soejima H, Hitomi Y, Kumagai K, Usui T, Hayashi T, Yamamoto D, Fukai R, Sugita S, Kitazato K, Hirata N, Honda R, Morota T, Tatsumi E, Sakatani N, Namiki N, Matsumoto K, Noguchi R, Wada K, Senshu H, Ogawa K, Yokota Y, Ishihara Y, Shimaki Y, Yamada M, Honda C, Michikami T, Matsuoka M, Hirata N, Arakawa M, Okamoto C, Ishiguro M, Jaumann R, Bibring JP, Grott M, Schröder S, Otto K, Pilorget C, Schmitz N, Biele J, Ho TM, Moussi-Soffys A, Miura A, Noda H, Yamada T, Yoshihara K, Kawahara K, Ikeda H, Yamamoto Y, Shirai K, Kikuchi S, Ogawa N, Takeuchi H, Ono G, Mimasu Y, Yoshikawa K, Takei Y, Fujii A, Iijima YI, Nakazawa S, Hosoda S, Iwata T, Hayakawa M, Sawada H, Yano H, Tsukizaki R, Ozaki M, Terui F, Tanaka S, Fujimoto M, Yoshikawa M, Saiki T, Tachibana S, Watanabe SI, Tsuda Y

Science (New York, N.Y.) Vol. 379 ( 6634 ) page： eabn9057 2023.2

Formation and evolution of carbonaceous asteroid Ryugu: Direct evidence from returned samples. Open Access

Nakamura T, Matsumoto M, Amano K, Enokido Y, Zolensky ME, Mikouchi T, Genda H, Tanaka S, Zolotov MY, Kurosawa K, Wakita S, Hyodo R, Nagano H, Nakashima D, Takahashi Y, Fujioka Y, Kikuiri M, Kagawa E, Matsuoka M, Brearley AJ, Tsuchiyama A, Uesugi M, Matsuno J, Kimura Y, Sato M, Milliken RE, Tatsumi E, Sugita S, Hiroi T, Kitazato K, Brownlee D, Joswiak DJ, Takahashi M, Ninomiya K, Takahashi T, Osawa T, Terada K, Brenker FE, Tkalcec BJ, Vincze L, Brunetto R, Aléon-Toppani A, Chan QHS, Roskosz M, Viennet JC, Beck P, Alp EE, Michikami T, Nagaashi Y, Tsuji T, Ino Y, Martinez J, Han J, Dolocan A, Bodnar RJ, Tanaka M, Yoshida H, Sugiyama K, King AJ, Fukushi K, Suga H, Yamashita S, Kawai T, Inoue K, Nakato A, Noguchi T, Vilas F, Hendrix AR, Jaramillo-Correa C, Domingue DL, Dominguez G, Gainsforth Z, Engrand C, Duprat J, Russell SS, Bonato E, Ma C, Kawamoto T, Wada T, Watanabe S, Endo R, Enju S, Riu L, Rubino S, Tack P, Takeshita S, Takeichi Y, Takeuchi A, Takigawa A, Takir D, Tanigaki T, Taniguchi A, Tsukamoto K, Yagi T, Yamada S, Yamamoto K, Yamashita Y, Yasutake M, Uesugi K, Umegaki I, Chiu I, Ishizaki T, Okumura S, Palomba E, Pilorget C, Potin SM, Alasli A, Anada S, Araki Y, Sakatani N, Schultz C, Sekizawa O, Sitzman SD, Sugiura K, Sun M, Dartois E, De Pauw E, Dionnet Z, Djouadi Z, Falkenberg G, Fujita R, Fukuma T, Gearba IR, Hagiya K, Hu MY, Kato T, Kawamura T, Kimura M, Kubo MK, Langenhorst F, Lantz C, Lavina B, Lindner M, Zhao J, Vekemans B, Baklouti D, Bazi B, Borondics F, Nagasawa S, Nishiyama G, Nitta K, Mathurin J, Matsumoto T, Mitsukawa I, Miura H, Miyake A, Miyake Y, Yurimoto H, Okazaki R, Yabuta H, Naraoka H, Sakamoto K, Tachibana S, Connolly HC Jr, Lauretta DS, Yoshitake M, Yoshikawa M, Yoshikawa K, Yoshihara K, Yokota Y, Yogata K, Yano H, Yamamoto Y, Yamamoto D, Yamada M, Yamada T, Yada T, Wada K, Usui T, Tsukizaki R, Terui F, Takeuchi H, Takei Y, Iwamae A, Soejima H, Shirai K, Shimaki Y, Senshu H, Sawada H, Saiki T, Ozaki M, Ono G, Okada T, Ogawa N, Ogawa K, Noguchi R, Noda H, Nishimura M, Namiki N, Nakazawa S, Morota T, Miyazaki A, Miura A, Mimasu Y, Matsumoto K, Kumagai K, Kouyama T, Kikuchi S, Kawahara K, Kameda S, Iwata T, Ishihara Y, Ishiguro M, Ikeda H, Hosoda S, Honda R, Honda C, Hitomi Y, Hirata N, Hirata N, Hayashi T, Hayakawa M, Hatakeda K, Furuya S, Fukai R, Fujii A, Cho Y, Arakawa M, Abe M, Watanabe S, Tsuda Y

Science (New York, N.Y.) Vol. 379 ( 6634 ) page： eabn8671 2023.2

Fetal growth restriction followed by early catch-up growth impairs pancreatic islet morphology in male rats. International journal Open Access

Mahboba Jabary, Atsuto Onoda, Yuma Kitase, Kazuto Ueda, Haruka Mimatsu, Shoji Go, Ryosuke Miura, Masahiro Tsuji, Yoshiyuki Takahashi, Masahiro Hayakawa, Yoshiaki Sato

Scientific reports Vol. 13 ( 1 ) page： 2732 - 2732 2023.2

Language：English Publishing type：Research paper (scientific journal)

Fetal growth restriction (FGR), followed by postnatal early catch-up growth, is associated with an increased risk of metabolic dysfunction, including type 2 diabetes in humans. This study aims to determine the effects of FGR and early catch-up growth after birth on the pathogenesis of type 2 diabetes, with particular attention to glucose tolerance, pancreatic islet morphology, and fibrosis, and to elucidate its mechanism using proteomics analysis. The FGR rat model was made by inducing mild intrauterine hypoperfusion using ameroid constrictors (ACs). On day 17 of pregnancy, ACs were affixed to the uterine and ovarian arteries bilaterally, causing a 20.9% reduction in birth weight compared to sham pups. On postnatal day 4 (P4), the pups were assigned to either the good nutrition (GN) groups with 5 pups per dam to ensure postnatal catch-up growth or poor nutrition groups with 15 pups per dam to maintain lower body weight. After weaning, all pups were fed regular chow food ad libitum (P21). Rats in both FGR groups developed glucose intolerance; however, male rats in the FGR good nutrition (FGR-GN) group also developed hypertriglyceridemia and dysmorphic pancreatic islets with fibrosis. A comprehensive and functional analysis of proteins expressed in the pancreas showed that FGR, followed by early catch-up growth, severely aggravated cell adhesion-related protein expression in male offspring. Thus, FGR and early catch-up growth caused pancreatic islet morphological abnormalities and fibrosis associated with the disturbance of cell adhesion-related protein expressions. These changes likely induce glucose intolerance and dyslipidemia in male rats.

DOI： 10.1038/s41598-023-28584-2

Open Access

Web of Science

PubMed

新規新生児マススクリーニングで診断し,乳児期にHLAハプロ移植を施行したムコ多糖症I型

若松学, 村松秀城, 横井克幸, 中島葉子, 山下大紀, 佐治木大知, 前村遼, 津村悠介, 山森彩子, 今屋雅之, 成田幸太郎, 谷口理恵子, 片岡伸介, 成田敦, 西尾信博, 酒井好美, 伊藤哲哉, 高橋義行

日本小児科学会雑誌 Vol. 127 ( 2 ) page： 244 - 244 2023.2

EBウイルス関連血球貪食性リンパ組織球症のシングルセルシーケンスによる病態解析

鈴木高子, 佐藤好隆, 鳥居ゆか, 福田悠人, 春田一憲, 山口慎, 奥野友介, 濱麻人, 高橋義行, 木村宏, 伊藤嘉規, 川田潤一

日本小児科学会雑誌 Vol. 127 ( 2 ) page： 190 - 190 2023.2

Medical records as screening tools for child death review in Japan. Open Access

Numaguchi A, Ishii A, Natsume J, Saitoh S, Aoki Y, Yoshikawa T, Isobe I, Okumura A, Seno H, Takahashi Y

Pediatrics international : official journal of the Japan Pediatric Society Vol. 65 ( 1 ) page： e15692 2023.1

Late gastroenterological complications in children after allogeneic hematopoietic stem cell transplantation: A retrospective cohort study and a case series of children treated with Kampo medicines Open Access

Nozomu Kawashima, Shinsuke Kataoka, Motoharu Hamada, Eri Nishikawa, Rieko Taniguchi, Atsushi Narita, Hideki Muramatsu, Nobuhiro Nishio, Yoshiyuki Takahashi

Traditional and Kampo Medicine 2023

Language：English Publishing type：Research paper (scientific journal)

Aim: This study aimed to describe children developing late gastrointestinal (GI) complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT), focusing on Kampo medicine. Methods: At the Nagoya University Hospital Department of Pediatrics, 179 consecutive patients underwent allo-HSCT over five years, of whom 167 achieved engraftment and survived at least 100 days post transplant and therefore were included in the study. Results: Thirteen patients (7.8%) developed late GI symptoms. Among these, three had upper GI symptoms, three had lower GI symptoms, while seven had upper/lower GI symptoms. Total parenteral nutrition was administered in 10 (77%) patients for a median of 81 days (range: 20–303). Four (31%) had histologically proven graft-versus-host-disease (GVHD), two (15%) had adverse drug reactions, and one (8%) had a viral infection. All three patients with lower GI symptoms responded to Kampo formulas' warming interior [TM1]. Two patients with upper GI symptoms had epigastric rigidity and responded to Aurantii Fructus Immaturus-based formulas. One patient developed severe cachexia, which was successfully reversed with Kampo medicines. There were no adverse effects due to Kampo medicines. Conclusions: Late GI complications may be a burden on children after allo-HSCT. Kampo medicines may provide a safe and promising therapy to resolve GI symptoms not otherwise specified.

DOI： 10.1002/tkm2.1392

Open Access

Scopus

[Chimeric antigen receptor (CAR) T cells targeting CD19 for acute lymphoblastic leukemia].

Takahashi Y, Nishio N

[Rinsho ketsueki] The Japanese journal of clinical hematology Vol. 64 ( 9 ) page： 1184 - 1191 2023

Ruxolitinib in Pediatric Patients with Treatment-<i>Naive</i> or Steroid-Refractory Acute Graft-Versus-Host Disease: Primary Findings from the Phase I/II REACH4 Study

Locatelli, F; Kang, HJ; Bruno, B; Gandemer, V; Rialland, F; Faraci, M; Takahashi, Y; Koh, K; Bittencourt, H; Cleary, G; Rosko, C; Roussou, P; St Pierre, A; Prahallad, A; Díaz-de-Heredia, C

BLOOD Vol. 140 page： 1376 - 1378 2022.11

Impact of the Coronavirus Disease 2019 Pandemic on the Clinical Features of Pediatric Respiratory Syncytial Virus Infection in Japan Reviewed Open Access

Shoko Ozeki, Jun-ichi Kawada, Daiki Yamashita, Chika Yasufuku, Takuya Akano, Masahiro Kato, Konomi Suzuki, Chihiro Tano, Kazuki Matsumoto, Shu-hei Mizutani, Ayumi Mori, Nobuhiro Nishio, Hiroyuki Kidokoro, Yoshihiro Yasui, Yoshiyuki Takahashi, Yoshiaki Sato, Anna Shiraki, Kazuto Ueda, Shotaro Ando, Noriko Nagai, Tsutomu Aoshima, Michio Suzuki, Tetsuo Kubota, Motomasa Suzuki, Satoru Doi, Daichi Fukumi, Yuichiro Sugiyama, Masafumi Morishita, Naoko Nishimura, Mizuki Takagi, Hirokazu Kurahashi, Yohei Takeuchi, Kenji Kuraishi, Osamu Shinohara, Takashi Kawabe, Nobuhiro Watanabe, Shinji Hasegawa, Taichiro Muto, Shinji Kido, Shinya Hara, Shin Hoshino

Open Forum Infectious Diseases Vol. 9 ( 11 ) page： ofac562 2022.11

Language：English Publishing type：Research paper (scientific journal) Publisher：Oxford University Press (OUP)

Abstract

Background

Mitigation measures implemented during the coronavirus disease 2019 (COVID-19) pandemic remarkably reduced the incidence of infectious diseases among children. However, a re-emergence of respiratory syncytial virus (RSV) infection was observed in 2021 in Japan. We compared the clinical characteristics of hospitalized patients with RSV infection before and during COVID-19.

Methods

We retrospectively enrolled children aged &lt;6 years who were hospitalized with RSV infection in 18 hospitals and compared their clinical characteristics before (January 2019 to April 2020, 1675 patients) and during COVID-19 (September 2020 to December 2021, 1297 patients).

Results

The mean age of patients with RSV infection was significantly higher during COVID-19 than before (17.4 vs 13.7 months, P &lt; .001). Compared with before COVID-19, a 2.6-fold increase in RSV cases in the 2–5 years age group was observed from sentinel surveillance during COVID-19, whereas a 1.2-fold increase was noted in the same age group among hospitalized patients. On average for all patients, consolidation shadows obtained on radiography were less frequently observed (26.1 vs 29.6%, P = .04), and reduced respiratory assistance (42.2% vs 48.7%, P &lt; .001) and hospitalization stay (5.7 vs 6.0 days, P &lt; .001) was required in patients with RSV infection during COVID-19.

Conclusions

Coronavirus disease 2019 and social activity restriction caused epidemiological changes in pediatric RSV infections, and a majority of patients with RSV infection aged ≥2 years did not develop severe symptoms requiring hospitalization. The RSV symptoms during the COVID-19 outbreak were equivalent to or milder than in the previous seasons.

DOI： 10.1093/ofid/ofac562

Open Access

Web of Science

PubMed

Other Link： https://academic.oup.com/ofid/article-pdf/9/11/ofac562/47043659/ofac562.pdf

CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY FOLLOWED BY UR-BMT IN TYROSINE KINASE INHIBITOR RESISTANT PEDIATRIC PH1-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA

Imaya, M; Narita, A; Nishio, N; Wakamatsu, M; Taniguchi, R; Kataoka, S; Muramatsu, H; Ichikawa, D; Maeda, N; Takahashi, Y