Faculty Profiles - TAKAHASHI, Yoshiyuki

Papers - TAKAHASHI, Yoshiyuki

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Combination of tumor necrosis factor-α and epidermal growth factor induces the adrenergic-to-mesenchymal transdifferentiation in SH-SY5Y neuroblastoma cells. International journal Open Access

Yue Huang, Shoma Tsubota, Nobuhiro Nishio, Yoshiyuki Takahashi, Kenji Kadomatsu

Cancer science Vol. 112 ( 2 ) page： 715 - 724 2021.2

Language：English Publishing type：Research paper (scientific journal)

Neuroblastoma, a type of cancer that is common in children, is composed of two genetically clonal but epigenetically distinct cell types: mesenchymal (MES) and adrenergic (ADRN) types, controlled by super-enhancer-associated lineage-specific transcription factor networks. Mesenchymal-type cells are more migratory, resistant to chemotherapy, and prevalent in relapse tumors. Importantly, both cell types spontaneously transdifferentiate into one another, and this interconversion can be induced by genetic manipulations. However, the mechanisms of their spontaneous transdifferentiation and extracellular factors inducing this phenomenon have not yet been elucidated. Using a unique approach involving gene set enrichment analysis, we selected six ADRN and 10 MES candidate factors, possibly inducing ADRN and MES phenotypes, respectively. Treatment with a combination of 10 MES factors clearly induced the MES gene expression profile in ADRN-type SH-SY5Y neuroblastoma cells. Considering the effects on gene expression profile, migration ability, and chemoresistance, a combination of tumor necrosis factor alpha (TNF-α) and epidermal growth factor (EGF) was sufficient to synergistically induce the ADRN-to-MES transdifferentiation in SH-SY5Y cells. In addition, human neuroblastoma cohort analysis revealed that the expression of TNF and EGF receptors was strongly associated with MES gene expression signatures, supporting their important roles in transdifferentiation in vivo. Collectively, we propose a mechanism of neuroblastoma transdifferentiation induced by extracellular growth factors, which can be controlled in clinical situations, providing a new therapeutic possibility.

DOI： 10.1111/cas.14760

Open Access

Web of Science

PubMed

Shuffling babies and autism spectrum disorder. International journal

Yu Okai, Tomohiko Nakata, Kiyokuni Miura, Atsuko Ohno, Rie Wakako, Osamu Takahashi, Yuki Maki, Masaharu Tanaka, Yoko Sakaguchi, Yuji Ito, Hiroyuki Yamamoto, Hiroyuki Kidokoro, Yoshiyuki Takahashi, Jun Natsume

Brain & development Vol. 43 ( 2 ) page： 181 - 185 2021.2

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND AND PURPOSE: Bottom shuffling is a locomotion strategy that precedes independent walking in some infants. Shuffling babies are generally considered to have favorable outcomes. The aim of the present study was to reveal clinical features and neurodevelopmental outcomes of shuffling babies who visited a child developmental center. METHODS: We studied 48 shuffling babies who visited Toyota Municipal Child Development Center from April 2007 to March 2015. We excluded patients with cerebral palsy, Down syndrome, or congenital disorders. In 2018, we retrospectively reviewed the clinical charts of the enrolled children. We investigated family history, neurological findings, and the developmental outcome during the follow-up period. RESULTS: During the follow-up period, 20 children (42%) were diagnosed with ASD. Gross motor development in infancy was not different between infants with and without ASD. The rate of poor eye contact at the first visit and a delay in the first word speech were significantly higher in infants with ASD than in infants without ASD. A family history of bottom shuffling was significantly less frequent in infants with ASD (10%) than in those without (39%). CONCLUSION: Some of bottom shufflers may represent ASD during follow-up. Paying attention to social and cognitive functions in shuffling babies is important.

DOI： 10.1016/j.braindev.2020.08.007

Web of Science

PubMed

術前診断にて良性腫瘍と考えられたが全摘出できなかった腰髄腫瘍の2歳男児

吉田太郎, 村松秀城, 今屋雅之, 山森彩子, 若松学, 三輪田俊介, 成田幸太郎, 北澤宏展, 谷口理恵子, 市川大輔, 濱田太立, 西川英里, 川島希, 成田敦, 西尾信博, 小島勢二, 高橋義行, 田中智史, 安藤圭, 小林和克, 今釜史郎, 中黒匡人, 平戸純子

日本小児血液・がん学会雑誌 Vol. 57 ( 5 ) page： 409 - 410 2021.2

胎児発育不全に伴う脳発達異常の早期診断法確立に向けたバイオマーカーの探索

小野田淳人, 北瀬悠磨, 辻雅弘, 上田一仁, 高橋義行, 早川昌弘, 佐藤義朗

日本小児科学会雑誌 Vol. 125 ( 2 ) page： 216 - 216 2021.2

化学療法による治療介入を行った生後2ヵ月未満発症の神経芽腫4S

今屋雅之, 西川英里, 吉田太郎, 山森彩子, 若松学, 三輪田俊介, 成田幸太郎, 北澤宏展, 谷口理恵子, 市川大輔, 濱田太立, 川島希, 成田敦, 村松秀城, 西尾信博, 小島勢二, 高橋義行

日本小児血液・がん学会雑誌 Vol. 57 ( 5 ) page： 411 - 411 2021.2

Long-term outcome in patients with Fanconi anemia who received hematopoietic stem cell transplantation: a retrospective nationwide analysis.

Miharu Yabe, Tomohiro Morio, Ken Tabuchi, Daisuke Tomizawa, Daiichiro Hasegawa, Hiroyuki Ishida, Nao Yoshida, Takashi Koike, Yoshiyuki Takahashi, Katsuyoshi Koh, Yasuhiro Okamoto, Hideki Sano, Keisuke Kato, Yoshinobu Kanda, Hiroaki Goto, Junko Takita, Takako Miyamura, Maiko Noguchi, Koji Kato, Yoshiko Hashii, Yoshiko Astuta, Hiromasa Yabe

International journal of hematology Vol. 113 ( 1 ) page： 134 - 144 2021.1

Language：English Publishing type：Research paper (scientific journal)

We retrospectively analyzed nationwide records of 163 Fanconi anemia (FA) patients [aplastic anemia (AA), n = 118; myelodysplastic syndrome (MDS), n = 30; acute leukemia, n = 15] who underwent first allogeneic hematopoietic stem cell transplantation (HSCT) between 1987 and 2015 in Japan. An alternative donor was used in 119 (73%) patients, and 160 (98%) patients received a non-T-cell-depleted graft. With an 8.7-year median follow-up, 5-year overall survival (OS) was 81%. The 5-year OS was significantly higher in AA patients than in MDS and acute leukemia patients (89%, 71%, and 44%, respectively). In the MDS/leukemia group, factors associated with poor outcome in univariate analysis were older age at HSCT (≥ 18 years), conditioning regimen without anti-thymocyte or lymphocyte globulin, and grade II-IV acute graft-versus-host disease. After 1 year, of 137 survivors, 15 developed subsequent malignancies, of whom 12 were diagnosed with head and neck (HN)/esophageal cancer. An irradiation regimen and older age were associated with the risk of HN/esophageal cancer. Five of seven deaths were attributed to subsequent malignancies more than 5 years after HSCT. On the basis of the risk factors for HSCT in MDS/leukemia patients and subsequent malignancies, a more effective HSCT approach is required.

DOI： 10.1007/s12185-020-02991-x

Web of Science

PubMed

Detection of subclonal SETBP1 and JAK3 mutations in juvenile myelomonocytic leukemia using droplet digital PCR. Reviewed International journal

Manabu Wakamatsu, Yusuke Okuno, Norihiro Murakami, Shunsuke Miwata, Hironobu Kitazawa, Kotaro Narita, Shinsuke Kataoka, Daisuke Ichikawa, Motoharu Hamada, Rieko Taniguchi, Kyogo Suzuki, Nozomu Kawashima, Eri Nishikawa, Atsushi Narita, Nobuhiro Nishio, Seiji Kojima, Hideki Muramatsu, Yoshiyuki Takahashi

Leukemia Vol. 35 ( 1 ) page： 259 - 263 2021.1

A Breast-Fed Baby with Low KREC in TREC/KREC Newborn Screening Whose Mother Received Azathioprine Treatment

Manabu Wakamatsu, Hideki Muramatsu, Daiei Kojima, Yusuke Okuno, Yoshimi Sakai, Yoko Nakajima, Tetsuya Ito, Nozomu Kawashima, Atsushi Narita, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 67 2020.12

Allogeneic Stem Cell Transplantation from Alternative Donors for Children with Aplastic Anemia

Atsushi Narita, Hideki Muramatsu, Masayuki Imaya, Ayako Yamamori, Taro Yoshida, Manabu Wakamatsu, Shunsuke Miwata, Koutaro Narita, Hironobu Kitazawa, Rieko Taniguchi, Motoharu Hamada, Daisuke Ichikawa, Eri Nishikawa, Nozomu Kawashima, Yusuke Okuno, Nobuhiro Nishio, Seiji Kojima, Yoshiyuki Takahashi

BONE MARROW TRANSPLANTATION Vol. 55 ( SUPPL 1 ) page： 215 - 216 2020.12

Allogeneic Hematopoietic Cell Transplantation in First Remission in Children with AML: A Comparison of RIC and MAC

Asahito Hama, Daiki Yamashita, Daichi Sajiki, Hironobu Kitazawa, Hirotoshi Sakaguchi, Nao Yoshida, Nozomu Kawashima, Atsushi Narita, Hideki Muramatsu, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 67 2020.12

Clinical Features of Cord Colitis Syndrome in Children

Ryo Maemura, Atsushi Narita, Daisuke Ichikawa, Motoharu Hamada, Eri Nishikawa, Nozomu Kawashima, Nobuhiro Nishio, Hideki Muramatsu, Seiji Kojima, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 67 2020.12

Biomarkers for Distinguishing between acute GVHD and HHV-6B-Associated Skin Rash after Hematopoietic Stem Cell Transplantation

Miura, H; Kudo, K; Tanaka, M; Takahashi, Y; Kojima, S; Yoshikawa, T

PEDIATRIC BLOOD & CANCER Vol. 67 2020.12

INFANTILE HEMISPHERIC BRAIN TUMOR WITH A GOPC-ROS1 FUSION GENE: A CASE REPORT Open Access

Rieko Taniguchi, Atsushi Natsume, Nozomu Kawashima, Shinji Tanioka, Hideki Muramatsu, Motoharu Hamada, Daisuke Ichikawa, Masayuki Imaya, Kotaro Narita, Michihiro Kurimoto, Yoshiki Shiba, Kosuke Aoki, Fumiharu Ohka, Junko Hirato, Toshihiko Wakabayashi, Yoshiyuki Takahashi

NEURO-ONCOLOGY Vol. 22 page： 377 - 377 2020.12

Development of Donor-Derived T cell EBV-LPD with Identical EBV Genome after Allogeneic CBT in the NK Cell-Type CAEBV Patient

Masayuki Imaya, Yusuke Okuno, Nozomu Kawashima, Manabu Wakamatsu, Hideki Muramatsu, Nobuhiro Nishio, Akihisa Sawada, Junichi Kawada, Yoshinori Ito, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 67 2020.12

Favorable Prognosis of Patients with Intermediate-Risk Neuroblastoma Having Residual Tumor after Treatment

Nobuhiro Nishio, Daisuke Ichikawa, Motoharu Hamada, Eri Nishikawa, Nozomu Kawashima, Atsushi Narita, Hideki Muramatsu, Seiji Kojima, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 67 2020.12

Effect of Azacitidine in a Child with Fanconi Anemia and Myelodysplastic Syndrome Harboring Monosomy 7

Nozomu Kawashima, Masafumi Ito, Kotaro Narita, Daisuke Ichikawa, Eri Nishikawa, Atsushi Narita, Hideki Muramatsu, Nobuhiro Nishio, Seiji Kojima, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 67 2020.12

Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome Open Access

Yasuyoshi Oka, Motoharu Hamada, Yuka Nakazawa, Hideki Muramatsu, Yusuke Okuno, Koichiro Higasa, Mayuko Shimada, Honoka Takeshima, Katsuhiro Hanada, Taichi Hirano, Toshiro Kawakita, Hirotoshi Sakaguchi, Takuya Ichimura, Shuichi Ozono, Kotaro Yuge, Yoriko Watanabe, Yuko Kotani, Mutsumi Yamane, Yumiko Kasugai, Miyako Tanaka, Takayoshi Suganami, Shinichiro Nakada, Norisato Mitsutake, Yuichiro Hara, Kohji Kato, Seiji Mizuno, Noriko Miyake, Yosuke Kawai, Katsushi Tokunaga, Masao Nagasaki, Seiji Kito, Keiichi Isoyama, Masafumi Onodera, Hideo Kaneko, Naomichi Matsumoto, Fumihiko Matsuda, Keitaro Matsuo, Yoshiyuki Takahashi, Tomoji Mashimo, Seiji Kojima, Tomoo Ogi

Science Advances Vol. 6 ( 51 ) page： eabd7197 - eabd7197 2020.12

Language：English Publishing type：Research paper (scientific journal) Publisher：American Association for the Advancement of Science (AAAS)

Rs671 in the aldehyde dehydrogenase 2 gene (<italic>ALDH2</italic>) is the cause of Asian alcohol flushing response after drinking. ALDH2 detoxifies endogenous aldehydes, which are the major source of DNA damage repaired by the Fanconi anemia pathway. Here, we show that the rs671 defective allele in combination with mutations in the alcohol dehydrogenase 5 gene, which encodes formaldehyde dehydrogenase (<italic>ADH5FDH</italic>), causes a previously unidentified disorder, AMeD (aplastic anemia, mental retardation, and dwarfism) syndrome. Cellular studies revealed that a decrease in the formaldehyde tolerance underlies a loss of differentiation and proliferation capacity of hematopoietic stem cells. Moreover, <italic>Adh5−/−Aldh2</italic>E506K/E506K double-deficient mice recapitulated key clinical features of AMeDS, showing short life span, dwarfism, and hematopoietic failure. Collectively, our results suggest that the combined deficiency of formaldehyde clearance mechanisms leads to the complex clinical features due to overload of formaldehyde-induced DNA damage, thereby saturation of DNA repair processes.

DOI： 10.1126/sciadv.abd7197

Open Access

Web of Science

PubMed

Hematopoietic Stem Cell Transplantation for Inborn Errors of Immunity in Japan: Overview of a Nationwide Retrospective Analysis

Miyamoto, S; Yanagimachi, M; Umeda, K; Iguchi, A; Sasahara, Y; Takada, H; Yamada, M; Ishimura, M; Koike, T; Yasui, M; Takahashi, Y; Kawaguchi, H; Kajiwara, M; Inoue, M; Kato, K; Hashii, Y; Atsuta, Y; Yabe, H; Imai, K; Morio, T

BONE MARROW TRANSPLANTATION Vol. 55 ( SUPPL 1 ) page： 102 - 103 2020.12

Hematopoietic Stem Cell Transplantation for Severe Combined Immunodeficiency in Japan: A Nationwide Retrospective Analysis

Miyamoto, S; Yanagimachi, M; Umeda, K; Iguchi, A; Sasahara, Y; Takada, H; Takahashi, Y; Kajiwara, M; Inoue, M; Kato, K; Hashii, Y; Atsuta, Y; Yabe, H; Imai, K; Morio, T

BONE MARROW TRANSPLANTATION Vol. 55 ( SUPPL 1 ) page： 443 - 443 2020.12

Viral Reactivations in Children with Aplastic Anemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Atsushi Narita, Yoshinori Ito, Nozomu Kawashima, Yusuke Okuno, Hideki Muramatsu, Nobuhiro Nishio, Yuka Torii, Junichi Kawada, Seiji Kojima, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 67 2020.12

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Papers - TAKAHASHI, Yoshiyuki