Faculty Profiles - TAKAHASHI, Yoshiyuki

Papers - TAKAHASHI, Yoshiyuki

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Retrospective Analysis of High Risk Childhood AML Undergoing Allo-SCT in First CR: Results of AML-05 by JPLSG

Nobuyuki Hyakuna, Yoshiko Hashii, Hiroyuki Ishida, Katsutsugu Umeda, Yoshiyuki Takahashi, Masayuki Nagasawa, Hiromasa Yabe, Yozo Nakazawa, Katsuyoshi Koh, Hiroaki Goto, Hiroyuki Fujisaki, Kimikazu Matsumoto, Harumi Kakuda, Michihiro Yano, Akio Tawa, Daisuke Tomizawa, Takashi Taga, Souichi Adachi, Koji Kato

PEDIATRIC BLOOD & CANCER Vol. 64 page： S68 - S68 2017.11

Successful Allogeneic Cord Blood Transplantation in three Children with Aplastic Anemia Pretreated with Flu plus Mel plus TBI

Eri Nishikawa, Hironobu Kitazawa, Koutarou Narita, Motoharu Hamada, Shinsuke Kataoka, Norihiro Murakami, Daisuke Ichikawa, Daiei Kojima, Kyogo Suzuki, Rieko Taniguchi, Nozomu Kawashima, Atsushi Narita, Yusuke Okuno, Hideki Muramatsu, Nobuhiro Nishio, Asahito Hama, Seiji Kojima, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 64 page： S75 - S76 2017.11

Treatment Outcomes and Prognostic Factors after Allogeneic-HSCT for Patients with Low and Intermediate Risk in JPLSG AML-05 study

Yoshiko Hashii, Nobuyuki Hyakuna, Hiroyuki Ishida, Katsutsugu Umeda, Yoshiyuki Takahashi, Masayuki Nagasawa, Hiromasa Yabe, Yozo Nakazawa, Hiroyuki Fujisaki, Michihiro Yano, Kimikazu Matsumoto, Hiroaki Goto, Harumi Kakuda, Katsuyoshi Koh, Daisuke Tomizawa, Akio Tawa, Takashi Taga, Souichi Adachi, Koji Kato

PEDIATRIC BLOOD & CANCER Vol. 64 page： S19 - S19 2017.11

Vorinostat and Bortezomib Combined Intensive Chemotherapy for Children with KMT2A (MLL)-rearranged Acute Lymphoblastic Leukemia

Suzuki Kyogo, Muramatsu Hideki, Okuno Yusuke, Narita Kotaro, Kitazawa Hironobu, Huang Yue, Ichikawa Daisuke, Kataoka Shinsuke, Hamada Motoharu, Murakami Norihiro, Taniguchi Rieko, Kojima Daiei, Sekiya Yuko, Nishikawa Eri, Kawashima Nozomu, Narita Atsushi, Nishio Nobuhiro, Hama Asahito, Kojima Seiji, Takahashi Yoshiyuki

PEDIATRIC BLOOD & CANCER Vol. 64 page： S90-S90 2017.11

難治性進行神経芽腫に対するKIRリガンド不一致同種臍帯血移植による再発抑制効果と生存率の向上(Killer cell immunoglobulin-like receptor ligand-mismatched allogeneic cord blood transplantation reduces relapse and improves survival in children with refractory neuroblastoma)

Nishio Nobuhiro, Kataoka Shinsuke, Hamada Motoharu, Ichikawa Daisuke, Taniguchi Rieko, Murakami Norihiro, Kojima Daiei, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Okuno Yusuke, Narita Atsushi, Muramatsu Hideki, Hama Asahito, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 54 ( 4 ) page： 227 - 227 2017.10

若年性骨髄単球性白血病に対する包括的遺伝子解析(Integrated molecular profiling of juvenile myelomonocytic leukemia)

Murakami Norihiro, Muramatsu Hideki, Okuno Yusuke, Yoshida Kenichi, Shiraishi Yuichi, Nagae Genta, Suzuki Kyogo, Narita Atsushi, Sakaguchi Hirotoshi, Kawashima Nozomu, Wang Xinan, Xu Yinyan, Chiba Kenichi, Tanaka Hiroko, Nishio Nobuhiro, Hama Asahito, Sanada Masashi, Hirayama Masashi, Watanabe Arata, Ueno Toshihide, Kojima Seiji, Aburatani Hiroyuki, Mano Hiroyuki, Miyano Satoru, Ogawa Seishi, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 54 ( 4 ) page： 224 - 224 2017.10

愛知県における重症複合免疫不全症に対する新生児マススクリーニング(Newborn screening for severe combined immunodeficiency in Aichi Prefecture)

Kojima Daiei, Muramatsu Hideki, Okuno Yusuke, Narita Kotaro, Murakami Norihiro, Ichikawa Daisuke, Hamada Motoharu, Kataoka Shinsuke, Kitazawa Hironobu, Taniguchi Rieko, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Narita Atsushi, Nishio Nobuhiro, Hama Asahito, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 54 ( 4 ) page： 238 - 238 2017.10

小児再生不良性貧血における胚細胞変異(Germline mutation in pediatric patients with aplastic anemia)

Narita Atsushi, Muramatsu Hideki, Okuno Yusuke, Wang Xinan, Xu Yinyan, Kawashima Nozomu, Nishio Nobuhiro, Hama Asahito, Sakaguchi Hirotoshi, Yoshida Nao, Kato Koji, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 54 ( 4 ) page： 233 - 233 2017.10

再発小児脳腫瘍に対するベバシズマブ・イリノテカン・テモゾロミド併用救援化学療法(Bevacizumab, Irinotecan, and Temozolomide combination as salvage chemotherapy for relapsed pediatric brain tumor)

Kataoka Shinsuke, Muramatsu Hideki, Narita Kotaro, Hamada Motoharu, Murakami Norihiro, Tanigushi Rieko, Ichikawa Daisuke, Kitazawa Hironori, Kojima Daiei, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Narita Atsushi, Okuno Yusuke, Nishio Nobuhiro, Hama Asahito, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 54 ( 4 ) page： 256 - 256 2017.10

ヒト遺伝性無効造血の原因となる新規FLVCR1遺伝子変異の同定(Identification of FLVCR1 as a novel causative gene of inherited ineffective erythropoiesis in humans)

Kawashima Nozomu, Okuno Yusuke, Shiota Mitsutaka, Muramatsu Hideki, Yoshida Kenichi, Ikawa Masahito, Hama Asahito, Ito Masafumi, Doisaki Sayoko, Murakami Norihiro, Suzuki Kyogo, Narita Atsushi, Nishio Nobuhiro, Takahashi Yoshiyuki, Ogawa Seishi, Kojima Seiji

日本小児血液・がん学会雑誌 Vol. 54 ( 4 ) page： 224 - 224 2017.10

KMT2A(MLL)遺伝子再構成陽性急性リンパ性白血病に対するボリノスタット・ボルテゾミブ併用化学療法(Vorinostat and bortezomib combined intensive chemotherapy for children with KMT2A(MLL)-rearranged acute lymphoblastic leukemia)

日本小児血液・がん学会雑誌 Vol. 54 ( 4 ) page： 287 - 287 2017.10

Flu+Mel+TBI前処置で同種臍帯血移植を施行した小児再生不良性貧血の3例(Successful allogeneic cord blood transplantation in three children with aplastic anemia pretreated with Flu+Mel+TBI)

Nishikawa Eri, Kitazawa Hironobu, Narita Kotaro, Hamada Motoharu, Kataoka Shinsuke, Murakami Norihiro, Ichikawa Daisuke, Kojima Daiei, Suzuki Kyogo, Taniguchi Rieko, Kawashima Nozomu, Narita Atsushi, Okuno Yusuke, Muramatsu Hideki, Nishio Nobuhiro, Hama Asahito, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 54 ( 4 ) page： 274 - 274 2017.10

Development of clinical paroxysmal nocturnal haemoglobinuria in children with aplastic anaemia. Reviewed International journal Open Access

Atsushi Narita, Hideki Muramatsu, Yusuke Okuno, Yuko Sekiya, Kyogo Suzuki, Motoharu Hamada, Shinsuke Kataoka, Daisuke Ichikawa, Rieko Taniguchi, Norihiro Murakami, Daiei Kojima, Eri Nishikawa, Nozomu Kawashima, Nobuhiro Nishio, Asahito Hama, Yoshiyuki Takahashi, Seiji Kojima

British journal of haematology Vol. 178 ( 6 ) page： 954 - 958 2017.9

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY

The clinical significance of paroxysmal nocturnal haemoglobinuria (PNH) in children with aplastic anaemia (AA) remains unclear. We retrospectively studied 57 children with AA between 1992 and 2010. During the follow-up, five patients developed clinical PNH, in whom somatic PIGA mutations were detected by targeted sequencing. The 10-year probability of clinical PNH development was 10·2% (95% confidence interval, 3·6-20·7%). Furthermore, the detection of minor PNH clones by flow cytometry at AA diagnosis was a risk factor for the subsequent development of clinical PNH. These patients with PNH clones at AA diagnosis should undergo periodic monitoring for potential clinical PNH development.

DOI： 10.1111/bjh.14790

Web of Science

PubMed

若年性骨髄単球性白血病に対する包括的遺伝子解析(Integrated molecular profiling of juvenile myelomonocytic leukemia)

Murakami Norihiro, Okuno Yusuke, Yoshida Kenichi, Shiraishi Yuichi, Nagae Genta, Suzuki Kyogo, Narita Atsushi, Sakaguchi Hirotoshi, Kawashima Nozomu, Wang Xinan, Xu Yinyan, Chiba Kenichi, Tanaka Hiroko, Hama Asahito, Sanada Masashi, Hirayama Masashi, Watanabe Arata, Ueno Toshihide, Kojima Seiji, Aburatani Hiroyuki, Mano Hiroyuki, Miyano Satoru, Ogawa Seishi, Takahashi Yoshiyuki, Muramatsu Hideki

臨床血液 Vol. 58 ( 9 ) page： 1457 - 1457 2017.9

先天性および後天性造血不全375例に対するクリニカルシーケンス(Clinical sequencing of 375 patients with inherited and acquired bone marrow failure syndromes)

Muramatsu Hideki, Okuno Yusuke, Yoshida Kenichi, Shiraishi Yuichi, Narita Atsushi, Sakaguchi Hirotoshi, Kawashima Nozomu, Xu Yinyan, Chiba Kenichi, Tanaka Hiroko, Hama Asahito, Sanada Masashi, Takahashi Yoshiyuki, Kanno Hitoshi, Yamaguchi Hiroki, Ohga Shouichi, Manabe Atsushi, Harigae Hideo, Kunishima Shinji, Ishii Eiichi, Kobayashi Masao, Koike Kenichi, Watanabe Kenichiro, Ito Etsuro, Takata Minoru, Yabe Miharu, Miyano Satoru, Ogawa Seishi, Kojima Seiji

臨床血液 Vol. 58 ( 9 ) page： 1519 - 1519 2017.9

Comparison of sperm subpopulation structures in first and second ejaculated semen from Japanese black bulls by a cluster analysis of sperm motility evaluated by a CASA system Reviewed Open Access

Chihiro Kanno, Kentaro Q. Sakamoto, Yojiro Yanagawa, Yoshiyuki Takahashi, Seiji Katagiri, Masashi Nagano

JOURNAL OF VETERINARY MEDICAL SCIENCE Vol. 79 ( 8 ) page： 1359 - 1365 2017.8

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN SOC VET SCI

In the present study, bull sperm in the first and second ejaculates were divided into subpopulations based on their motility characteristics using a cluster analysis of data from computer-assisted sperm motility analysis (CASA). Semen samples were collected from 4 Japanese black bulls. Data from 9,228 motile sperm were classified into 4 clusters; 1) very rapid and progressively motile sperm, 2) rapid and circularly motile sperm with widely moving heads, 3) moderately motile sperm with heads moving frequently in a short length, and 4) poorly motile sperm. The percentage of cluster 1 varied between bulls. The first ejaculates had a higher proportion of cluster 2 and lower proportion of cluster 3 than the second ejaculates.

DOI： 10.1292/jvms.17-0012

Open Access

Web of Science

PubMed

Bone marrow transplantation for children with acquired bone marrow failure

Hama A., Manabe A., Hasegawa D., Nozawa K., Suzuki K., Narita A., Muramatsu H., Takahashi Y., Watanabe K., Ohara A., Ito M., Kojima S.

BONE MARROW TRANSPLANTATION Vol. 52 page： S414 - S414 2017.7

Clinical utility of next-generation sequencing for inherited bone marrow failure syndromes. Reviewed International journal Open Access

Hideki Muramatsu, Yusuke Okuno, Kenichi Yoshida, Yuichi Shiraishi, Sayoko Doisaki, Atsushi Narita, Hirotoshi Sakaguchi, Nozomu Kawashima, Xinan Wang, Yinyan Xu, Kenichi Chiba, Hiroko Tanaka, Asahito Hama, Masashi Sanada, Yoshiyuki Takahashi, Hitoshi Kanno, Hiroki Yamaguchi, Shouichi Ohga, Atsushi Manabe, Hideo Harigae, Shinji Kunishima, Eiichi Ishii, Masao Kobayashi, Kenichi Koike, Kenichiro Watanabe, Etsuro Ito, Minoru Takata, Miharu Yabe, Seishi Ogawa, Satoru Miyano, Seiji Kojima

Genetics in medicine : official journal of the American College of Medical Genetics Vol. 19 ( 7 ) page： 796 - 802 2017.7

Language：English Publishing type：Research paper (scientific journal) Publisher：NATURE PUBLISHING GROUP

PURPOSE: Precise genetic diagnosis of inherited bone marrow failure syndromes (IBMFS), a heterogeneous group of genetic disorders, is challenging but essential for precise clinical decision making. METHODS: We analyzed 121 IBMFS patients using a targeted sequencing covering 184 associated genes and 250 IBMFS patients using whole-exome sequencing (WES). RESULTS: We achieved successful genetic diagnoses for 53 of 121 patients (44%) using targeted sequencing and for 68 of 250 patients (27%) using WES. In the majority of cases (targeted sequencing: 45/53, 85%; WES: 63/68, 93%), the detected variants were concordant with, and therefore supported, the clinical diagnoses. However, in the remaining 13 cases (8 patients by target sequencing and 5 patients by WES), the clinical diagnoses were incompatible with the detected variants. CONCLUSION: Our approach utilizing targeted sequencing and WES achieved satisfactory diagnostic rates and supported the efficacy of massive parallel sequencing as a diagnostic tool for IBMFS.Genet Med advance online publication 19 January 2017.

DOI： 10.1038/gim.2016.197

Web of Science

PubMed

PiggyBac transposon, a non-viral gene transfer system, mediated T cells expressing CD19 chimeric antigen receptor for a 'first in human' clinical trial

Takahashi, Y; Nishio, N; Hamada, M; Tanaka, M; Morita, D; Kawashima, N; Okuno, Y; Narita, A; Muramatsu, H; Hama, A; Kojima, S; Dotti, G; Nakazawa, Y

BONE MARROW TRANSPLANTATION Vol. 52 page： S161 - S162 2017.7

Recurrent MYB rearrangement in blastic plasmacytoid dendritic cell neoplasm

K Suzuki, Y Suzuki, A Hama, H Muramatsu, M Nakatochi, M Gunji, D Ichikawa, M Hamada, R Taniguchi, S Kataoka, N Murakami, D Kojima, Y Sekiya, E Nishikawa, N Kawashima, A Narita, N Nishio, Y Nakazawa, H Iwafuchi, K-i Watanabe, Y Takahashi, M Ito, S Kojima, S Kato, Y Okuno

Leukemia Vol. 31 ( 7 ) page： 1629 - 1633 2017.7

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Papers - TAKAHASHI, Yoshiyuki