Faculty Profiles - TAKAHASHI, Yoshiyuki

Papers - TAKAHASHI, Yoshiyuki

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A Case of Dyskeratosis Congenital who Showed the Improvement of Telomere Length After Receiving Androgens for 11 Years

Wakamatsu Manabu, Nishio Nobuhiro, Miwata Shunsuke, Narita Kotaro, Kitazawa Hironobu, Kataoka Shinsuke, Hamada Motoharu, Murakami Norihiro, Ichikawa Daisuke, Taniguchi Rieko, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Okuno Yusuke, Narita Atsushi, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

PEDIATRIC BLOOD & CANCER Vol. 65 page： S65-S65 2018.11

A Case of MLL-AF9 Fusion Positive Malignant Lymphoma Without Bone Marrow Infiltration Either at First Diagnosis or at Relapse

Narita Kotaro, Kataoka Shinsuke, Hamada Motoharu, Ichikawa Daisuke, Taniguchi Rieko, Murakami Norihiro, Suzuki Kyogo, Nishikawa Eri, Nishio Nobuhiro, Okuno Yusuke, Kawashima Nozomu, Narita Atsushi, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

PEDIATRIC BLOOD & CANCER Vol. 65 page： S99-S99 2018.11

A Case of Thoracic Tumor Caused by SMARCA4 Biallelic Inactivation

Ichikawa Daisuke, Muramatsu Hideki, Okuno Yusuke, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Kitazawa Hironobu, Hamada Motoharu, Kataoka Shinsuke, Taniguchi Rieko, Murakami Norihiro, Suzuki Kyogo, Nishikawa Eri, Kawashima Nozomu, Narita Atsushi, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

PEDIATRIC BLOOD & CANCER Vol. 65 page： S74-S74 2018.11

Application of RNA Sequencing for Early Diagnosis of NUT Carcinoma: A Case Report

Miwata Shunsuke, Narita Atsushi, Wakamatsu Manabu, Narita Kotaro, Kitazawa Hironobu, Kataoka Shinsuke, Hamada Motoharu, Murakami Norihiro, Taniguchi Rieko, Ichikawa Daisuke, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Okuno Yusuke, Nishio Nobuhiro, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

PEDIATRIC BLOOD & CANCER Vol. 65 page： S74-S74 2018.11

骨髄MRDの消失は神経芽腫に対するKIRリガンド不一致同種臍帯血移植後の移植片対腫瘍効果を示唆する(Disappearance of minimal residual disease demonstrates graft versus neuroblastoma effect after KIR-ligand mismatched allogeneic cord blood transplantation)

Nishio Nobuhiro, Kataoka Shinsuke, Miwata Shunsuke, Narita Kotaro, Kitazawa Hironobu, Hamada Motoharu, Ichikawa Daisuke, Taniguchi Rieko, Murakami Norihiro, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Okuno Yusuke, Narita Atsushi, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 55 ( 4 ) page： 154 - 154 2018.10

自然寛解後に再発をきたしたKAT6A-EP300融合転写を伴う先天性急性骨髄性白血病(Relapse after spontaneous molecular remission in a female with congenital acute myeloid leukemia with KAT6A-EP300 fusion transcript)

Taniguchi Rieko, Kawashima Nozomu, Ikawa Yasuhiro, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Kataoka Shinsuke, Hamada Motoharu, Murakami Norihiro, Ichikawa Daisuke, Kitazawa Hironobu, Suzuki Kyogo, Nishikawa Eri, Narita Atsushi, Okuno Yusuke, Muramatsu Hideki, Nishio Nobuhiro, Nishimura Ryosei, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 55 ( 4 ) page： 314 - 314 2018.10

蛋白同化ステロイド内服を11年継続している先天性角化不全症の一例(A case of dyskeratosis congenital who showed the improvement of telomere length after receiving androgens for 11 years)

日本小児血液・がん学会雑誌 Vol. 55 ( 4 ) page： 246 - 246 2018.10

小児再生不良性貧血に対するUpfront移植を含むハプロ移植の7例(Urgent successful HLA-haploidentical stem cell transplantation in children with aplastic anemia considering upfront SCT strategy)

Nishikawa Eri, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Murakami Norihiro, Kataoka Shinsuke, Hamada Motoharu, Ichikawa Daisuke, Kitazawa Hironobu, Taniguchi Rieko, Suzuki Kyogo, Kawashima Nozomu, Okuno Yusuke, Narita Atsushi, Muramatsu Hideki, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 55 ( 4 ) page： 247 - 247 2018.10

小児がん拠点病院単一施設における漢方診療の患者ニーズ調査(Unmet medical needs for Japanese Kampo medicine in children with hematological and oncological disease)

Kawashima Nozomu, Miwata Shunsuke, Narita Kotaro, Kataoka Shinsuke, Hamada Motoharu, Murakami Norihiro, Ichikawa Daisuke, Suzuki Kyogo, Kitazawa Hironobu, Nishikawa Eri, Okuno Yusuke, Taniguchi Rieko, Narita Atsushi, Muramatsu Hideki, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 55 ( 4 ) page： 219 - 219 2018.10

SMARCA4の不活化変異により発症した胸部腫瘍の1例(A case of thoracic tumor caused by SMARCA4 biallelic inactivation)

日本小児血液・がん学会雑誌 Vol. 55 ( 4 ) page： 255 - 255 2018.10

シーケンスによる先天性骨髄不全症の診断(Diagnosis of Inherited Bone Marrow Failure Syndromes Using Sequencing Approaches)

Narita Atsushi, Muramatsu Hideki, Okuno Yusuke, Yoshida Kenichi, Shiraishi Yuichi, Sakaguchi Hirotoshi, Kawashima Nozomu, Wang Xinan, Xu Yinyan, Chiba Kenichi, Tanaka Hiroko, Hama Asahito, Sanada Masashi, Kanno Hitoshi, Yamaguchi Hiroki, Ohga Shouichi, Manabe Atsushi, Harigae Hideo, Kunishima Shinji, Ishii Eiichi, Kobayashi Masao, Koike Kenichi, Watanabe Kenichiro, Ito Etsuro, Takata Minoru, Yabe Miharu, Ogawa Seishi, Miyano Satoru, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 55 ( 4 ) page： 153 - 153 2018.10

初発時および再発時に骨髄浸潤を認めなかったMLL/AF9融合遺伝子を持つ悪性リンパ腫の1例(A case of MLL-AF9 fusion positive malignant lymphoma without bone marrow infiltration either at first diagnosis or at relapse)

日本小児血液・がん学会雑誌 Vol. 55 ( 4 ) page： 316 - 316 2018.10

RNAシーケンスが早期診断に有用であったNUT carcinomaの1例(Application of RNA sequencing for early diagnosis of NUT carcinoma: a case report)

日本小児血液・がん学会雑誌 Vol. 55 ( 4 ) page： 255 - 255 2018.10

DREAM法を用いた若年性骨髄単球性白血病に対するメチル化解析(NGS-based methylation analysis of juvenile myelomonocytic leukemia using the digital restriction enzyme analysis of methylation(DREAM) method)

Kitazawa Hironobu, Murakami Norihiro, Okuno Yusuke, Muramatsu Hideki, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Kataoka Shinsuke, Hamada Motoharu, Ichikawa Daisuke, Taniguchi Rieko, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Narita Atsushi, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 55 ( 4 ) page： 206 - 206 2018.10

Defibrotide for Prophylaxis of Hepatic Veno-Occlusive Disease Hematopoietic Stem Cell Transplantation: Results from the Japanese Prophylactic Use, Phase II, Randomized Trial

Kikuta, A; Fukuda, T; Ohashi, K; Taniguchi, S; Asano-Mori, Y; Horibe, K; Goto, H; Nakamae, H; Ogawa, H; Tamaki, H; Takahashi, Y; Kimura, T; Yoshimura, K; Umemura, K; Ogawa, C

BONE MARROW TRANSPLANTATION Vol. 53 page： 316 - 317 2018.9

Defibrotide for Treatment of Hepatic Veno-Occlusive Disease Following Hematopoietic Stem Cell Transplantation: Results from the Japanese Therapeutic Use Protocol

Kikuta, A; Fukuda, T; Ohashi, K; Taniguchi, S; Asano-Mori, Y; Horibe, K; Goto, H; Nakamae, H; Ogawa, H; Tamaki, H; Takahashi, Y; Kimura, T; Yoshimura, K; Umemura, K; Ogawa, C

BONE MARROW TRANSPLANTATION Vol. 53 page： 318 - 319 2018.9

Updated Treatment Algorism for Children with Acquired Aplastic Anemia: A Report from the Japan Childhood Aplastic Anemia Study Group

Yoshida, N; Narita, A; Muramatsu, H; Kobayashi, R; Yabe, H; Kudo, K; Yagasaki, H; Watanabe, K; Morimoto, A; Ito, E; Ohga, S; Ohara, A; Takahashi, Y; Kojima, S

BONE MARROW TRANSPLANTATION Vol. 53 page： 34 - 35 2018.9

Whole-exome analysis to detect congenital hemolytic anemia mimicking congenital dyserythropoietic anemia. Reviewed

Motoharu Hamada, Sayoko Doisaki, Yusuke Okuno, Hideki Muramatsu, Asahito Hama, Nozomu Kawashima, Atsushi Narita, Nobuhiro Nishio, Kenichi Yoshida, Hitoshi Kanno, Atsushi Manabe, Takashi Taga, Yoshiyuki Takahashi, Satoru Miyano, Seishi Ogawa, Seiji Kojima

International journal of hematology Vol. 108 ( 3 ) page： 306 - 311 2018.9

Language：English Publishing type：Research paper (scientific journal)

Congenital dyserythropoietic anemia (CDA) is a heterogeneous group of rare congenital disorders characterized by ineffective erythropoiesis and dysplastic changes in erythroblasts. Diagnosis of CDA is based primarily on the morphology of bone marrow erythroblasts; however, genetic tests have recently become more important. Here, we performed genetic analysis of 10 Japanese patients who had been diagnosed with CDA based on laboratory findings and morphological characteristics. We examined 10 CDA patients via central review of bone marrow morphology and genetic analysis for congenital bone marrow failure syndromes. Sanger sequencing for CDAN1, SEC23B, and KLF1 was performed for all patients. We performed whole-exome sequencing in patients without mutation in these genes. Three patients carried pathogenic CDAN1 mutations, whereas no SEC23B mutations were identified in our cohort. WES unexpectedly identified gene mutations known to cause congenital hemolytic anemia in two patients: canonical G6PD p.Val394Leu mutation and SPTA1 p.Arg28His mutation. Comprehensive genetic analysis is warranted for more effective diagnosis of patients with suspected CDA.

DOI： 10.1007/s12185-018-2482-7

Web of Science

PubMed

Risk Factors for Viral Infections in Pediatric Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Narita, A; Ito, Y; Torii, Y; Kawada, JI; Miwata, S; Narita, K; Kitazawa, H; Hamada, M; Kataoka, S; Ichikawa, D; Ito, R; Murakami, N; Kojima, D; Suzuki, K; Nishikawa, E; Kawashima, N; Okuno, Y; Muramatsu, H; Hama, A; Kojima, S; Takahashi, Y

BONE MARROW TRANSPLANTATION Vol. 53 page： 588 - 589 2018.9

Serum anti-<i>Helicobacter pylori</i> antibody titer and its association with gastric nodularity, atrophy, and age: A cross-sectional study. Reviewed International journal Open Access

Toyoshima O, Nishizawa T, Sakitani K, Yamakawa T, Takahashi Y, Yamamichi N, Hata K, Seto Y, Koike K, Watanabe H, Suzuki H

World journal of gastroenterology Vol. 24 ( 35 ) page： 4061 - 4068 2018.9

Language：English Publishing type：Research paper (scientific journal)

AIM: To clarify the role of serum anti-Helicobacter pylori (H. pylori) antibody titers in gastric cancer. METHODS: In this cross-sectional study, the effect of patients' baseline characteristics and endoscopic findings on their serum antibody titers were assessed. We evaluated consecutive patients who underwent esophagogastroduodenoscopy and their first evaluation for H. pylori infection using a serum antibody test. We excluded patients with a history of eradication therapy. The participants were divided into four groups according to their E-plate serum antibody titer. Patients with serum antibody titers < 3, 3-9.9, 10-49.9, and ≥ 50 U/mL were classified into groups A, B, C, and D, respectively. RESULTS: In total, 874 participants were analyzed with 70%, 16%, 8.7%, and 5.1% of them in the groups A, B, C, and D, respectively. Patients in group C were older than patients in groups A and B. Gastric open-type atrophy, intestinal metaplasia, enlarged folds, diffuse redness, and duodenal ulcers were associated with a high titer. Regular arrangements of collecting venules, fundic gland polyps, superficial gastritis, and gastroesophageal reflux disease were related to a low titer. Multivariate analysis revealed that nodularity (P = 0.0094), atrophy (P = 0.0076), and age 40-59 years (vs age ≥ 60 years, P = 0.0090) were correlated with a high serum antibody titer in H. pylori-infected patients. Intestinal metaplasia and atrophy were related to age ≥ 60 years in group C and D. CONCLUSION: Serum antibody titer changes with age, reflects gastric mucosal inflammation, and is useful in predicting the risk of gastric cancer.

DOI： 10.3748/wjg.v24.i35.4061

Open Access

PubMed

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Papers - TAKAHASHI, Yoshiyuki