Faculty Profiles - TAKAHASHI, Yoshiyuki

Papers - TAKAHASHI, Yoshiyuki

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Planetary-scale streak structure reproduced in high-resolution simulations of the Venus atmosphere with a low-stability layer Reviewed Open Access

Hiroki Kashimura, Norihiko Sugimoto, Masahiro Takagi, Yoshihisa Matsuda, Wataru Ohfuchi, Takeshi Enomoto, Kensuke Nakajima, Masaki Ishiwatari, Takao M. Sato, George L. Hashimoto, Takehiko Satoh, Yoshiyuki O. Takahashi, Yoshi-Yuki Hayashi

NATURE COMMUNICATIONS Vol. 10 ( 1 ) page： 23 2019.1

Language：English Publishing type：Research paper (scientific journal) Publisher：NATURE PUBLISHING GROUP

Cloud patterns are important clues for revealing the atmospheric circulation of Venus. Recently, a planetary-scale streak structure has been discovered in middle- and lower-cloud images of Venus' night-side taken by IR2, the 2-mu m camera, on board the Akatsuki orbiter. However, its formation mechanism has not been investigated. Here we succeed, for the first time, in reproducing the patterns of the observed streak structure, as regions of strong downward flows that develop in high-resolution global simulations of the Venus atmosphere. The streaks are formed in both hemispheres with equatorial symmetry, which is caused by equatorial Rossby-like and Kelvin-like waves with zonal wavenumber one. The low-stability layer that has been suggested by past observations is essential for reproducing the streak structure. The streaks of downward flow result from the interaction of the meridionally tilted phase lines of the Rossby-like waves and the characteristics of baroclinic instability produced around the low-stability layer.

DOI： 10.1038/s41467-018-07919-y

Open Access

Web of Science

PubMed

Investigation of appropriate semi-quantitative index for assessment of esophageal and breast cancer treatment response in Japanese patients using <sup>18</sup>F-FDG PET/CT findings. Reviewed

Tsuchitani T, Takahashi Y, Maeda Y, Oda M, Enoki T, Kotoura N, Kitajima K

Hellenic journal of nuclear medicine Vol. 22 ( 1 ) page： 20 - 24 2019.1

A novel CUL4B splice site variant in a young male exhibiting less pronounced features. Reviewed International journal

Yuji Nakamura, Yusuke Okuno, Hideki Muramatsu, Tomoko Kawai, Kazuhito Satou, Daisuke Ieda, Ikumi Hori, Kei Ohashi, Yutaka Negishi, Ayako Hattori, Yoshiyuki Takahashi, Seiji Kojima, Shinji Saitoh

Human genome variation Vol. 6 page： 43 - 43 2019

Language：English Publishing type：Research paper (scientific journal)

Patients with variants in CUL4B exhibit syndromic intellectual disability (MIM #300354). A seven-year-old boy presented with intellectual disability, a history of seizure, characteristic facial features, and short stature. Whole-exome sequencing detected a c.974+3A>G variant in CUL4B, which was subsequently confirmed to disrupt mRNA splicing. The current patient showed less pronounced phenotypic features compared with the previously reported cases. This report, therefore, provides evidence of genotype-phenotype correlations in CUL4B-related disorders.

DOI： 10.1038/s41439-019-0074-6

Web of Science

PubMed

[LOCALIZED AMYLOIDOSIS OF THE RENAL SINUS: A CASE REPORT].

Ohashi T, Tanaka J, Asai K, Shimada S, Takahashi Y, Furukawa T

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology Vol. 110 ( 3 ) page： 191 - 195 2019

Ureteral dilatation detected in magnetic resonance imaging predicts vesicoureteral reflux in children with urinary tract infection. Reviewed International journal Open Access

Norihiro Murakami, Jun-Ichi Kawada, Azumi Watanabe, Toshinao Arakawa, Takamasa Kano, Takako Suzuki, Ryo Tanaka, Daiei Kojima, Yoshihiko Kawano, Shin Hoshino, Hideki Muramatsu, Yoshiyuki Takahashi, Yoshiaki Sato, Masashi Koyama, Jun Natsume

PloS one Vol. 13 ( 12 ) page： e0209595 2018.12

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Urinary tract infection (UTI), one of the most common bacterial infections occurring during infancy and early childhood, is frequently associated with vesicoureteral reflux (VUR). Although several guidelines recommend performing ultrasonography as a screening test, its utility is not adequate and appropriate screening tests are strongly desirable. In this study, we evaluate the use of magnetic resonance imaging (MRI) as a screening test for VUR in children with UTI. METHODS: We prospectively studied 108 patients with suspected UTI between April 2014 and March 2016. UTI was diagnosed on the basis of diffusion-weighted MRI (DW-MRI) and urine culture findings. We measured ureteral dilatation using MRI in 96 patients with UTI and assessed the relationship between ureteral dilatation in MRI and VUR in 46 patients who underwent voiding cystourethrography (VCUG). RESULTS: Among 108 patients, 88 and 8 were diagnosed with upper and lower UTI, respectively. Among 46 patients who underwent VCUG, 23 had VUR (14 low grade and 9 high grade). Patients with ureteral dilatation detected on MRI had VUR more frequently than those without ureteral dilatation (any grades VUR, 71% vs. 32%; P = 0.02; high-grade VUR, 38% vs. 2%, P = 0.007). Overall, ureteral dilatation findings on MRI achieved sensitivity 65.2% and specificity 73.9% as a screening test for VUR. In addition, DW-MRI achieved sensitivity 100% and specificity 81.8% in the diagnosis of upper UTI. CONCLUSION: These findings suggested that MRI is a valuable tool for screening of VUR as well as diagnosis of upper UTI.

DOI： 10.1371/journal.pone.0209595

Open Access

Web of Science

PubMed

Identification of potential pathogenic viruses in patients with acute myocarditis using next-generation sequencing. Reviewed International journal

Suguru Takeuchi, Jun-Ichi Kawada, Yusuke Okuno, Kazuhiro Horiba, Takako Suzuki, Yuka Torii, Kazushi Yasuda, Atsushi Numaguchi, Taichi Kato, Yoshiyuki Takahashi, Yoshinori Ito

Journal of medical virology Vol. 90 ( 12 ) page： 1814 - 1821 2018.12

Language：English Publishing type：Research paper (scientific journal)

Myocarditis is an inflammatory disease of the myocardium and leads to cardiac dysfunction and heart failure. Although viral infections are considered to be the most common etiology of myocarditis, the identification of the causative virus is still challenging. Recently, next-generation sequencing (NGS) has been applied in the diagnosis of infectious diseases. The aim of the current study was to comprehensively analyze potential pathogenic microorganisms using NGS in the sera of patients with myocarditis. Twelve pediatric and five adult patients hospitalized for acute myocarditis were included. Serum samples in the acute phase were obtained and analyzed using NGS to detect pathogen-derived DNA and RNA. Viral sequence reads were detected in 7 (41%) of the 17 myocarditis patients by NGS. Among these patients, detection of Epstein-Barr virus, human parvovirus B19, torque teno virus, and respiratory syncytial virus reads by NGS was consistent with polymerase chain reaction or antigen test results in one patient each. A large number of human pegivirus reads were detected from one patient by RNA sequencing; however, its pathogenicity to human is unknown. Conversely, the number of detected virus-derived reads was small in most cases, and the pathophysiological role of these viruses remains to be clarified. No significant bacterial or fungal reads other than normal bacterial flora was detected. These data indicate that comprehensive detection of virus-derived DNA and RNA using NGS can be useful for the identification of potential pathogenic viruses in myocarditis.

DOI： 10.1002/jmv.25263

Web of Science

PubMed

Reduction of stratum corneum ceramides in Neu-Laxova syndrome caused by phosphoglycerate dehydrogenase deficiency. Reviewed International journal Open Access

Takuya Takeichi, Yusuke Okuno, Akane Kawamoto, Takeshi Inoue, Eiko Nagamoto, Chiaki Murase, Eri Shimizu, Kenichi Tanaka, Yuichi Kageshita, Satoshi Fukushima, Michihiro Kono, Junko Ishikawa, Hironobu Ihn, Yoshiyuki Takahashi, Masashi Akiyama

Journal of lipid research Vol. 59 ( 12 ) page： 2413 - 2420 2018.12

Language：English Publishing type：Research paper (scientific journal)

Neu-Laxova syndrome (NLS) is a very rare autosomal recessive congenital disorder characterized by disturbed development of the central nervous system and the skin and caused by mutations in any of the three genes involved in de novo l-serine biosynthesis: PHGDH, PSAT1, and PSPH l-Serine is essential for the biosynthesis of phosphatidylserine and sphingolipids. The extracellular lipid of the stratum corneum, of which sphingolipid constitutes a significant part, plays a primary role in skin barrier function. Here, we describe a Japanese NLS pedigree with a previously unreported nonsense mutation in PHGDH and a unique inversion of chromosome 1. In addition, the levels of 11 major ceramide classes in the tape-stripped stratum corneum of the NLS patient's skin were assessed by LC/MS. Notably, lower amounts of ceramides of all classes were found in the patient's stratum corneum than in those of controls. This is the first report to demonstrate the reduction of ceramides in the stratum corneum of an NLS patient due to PHGDH mutations. The clinical findings and a detailed analysis of ceramides from the stratum corneum in the family extend the spectrum of clinical anomalies and give us a clue to the pathomechanisms of ichthyosis in NLS patients with phosphoglycerate dehydrogenase deficiency.

DOI： 10.1194/jlr.P087536

Open Access

Web of Science

PubMed

The presence of defective Epstein-Barr virus (EBV) infection in EBV-associated hematological malignancies

Okuno, Y; Murata, T; Sato, Y; Ito, Y; Yoshida, K; Sawada, A; Shiraishi, Y; Miyano, S; Takahashi, Y; Kojima, S; Ogawa, S; Kimura, H

CANCER SCIENCE Vol. 109 page： 642 - 642 2018.12

The presence of defective Epstein-Barr virus (EBV) infection in EBV-associated hematological malignancies

Okuno Yusuke, Murata Takayuki, Sato Yoshitaka, Ito Yoshinori, Yoshida Kenichi, Sawada Akihisa, Shiraishi Yuichi, Miyano Satoru, Takahashi Yoshiyuki, Kojima Seiji, Ogawa Seishi, Kimura Hiroshi

CANCER SCIENCE Vol. 109 page： 642-642 2018.12

Clinical and Genetic Characteristics of Patients with Shwachman-Diamond Syndrome in Japan Open Access

Watanabe Kenichiro, Kanegane Hirokazu, Hamabata Takayuki, Kozuki Kagehiro, Umeda Katsutsugu, Ueno Hiroo, Yoshida Kenichi, Hama Asahito, Okuno Yusuke, Muramatsu Hideki, Takahashi Yoshiyuki, Hasegawa Daisuke, Manabe Atsushi, Ohara Akira, Ito Masafumi, Ogawa Seishi, Kojima Seiji, Ito Etsuro

BLOOD Vol. 132 2018.11

Combination of TREC Measurement and Next-Generation Sequencing in Newborn Screening for Severe Combined Immunodeficiency: A Pilot Program in Japan Open Access

Muramatsu Hideki, Kojima Daiei, Okuno Yusuke, Kataoka Shinsuke, Nakajima Yoko, Ito Tetsuya, Tsuge Ikuya, Yoshimi Sakai, Kato Tomoaki, Kojima Seiji, Takahashi Yoshiyuki

BLOOD Vol. 132 2018.11

<i>Piggybac</i> CD19 CAR T Cells Eradicate CNS Leukemia By Direct Delivery into Cerebral Ventricle of Xenograft Mice Model Open Access

Tanaka, K; Kato, I; Tanaka, M; Morita, D; Takahashi, Y; Nakahata, T; Umeda, K; Hiramatsu, H; Adachi, S; Takita, J; Nakazawa, Y

BLOOD Vol. 132 2018.11

Randomized Trial of Two Dosages of Rabbit Antithymocyte Globulin in Patients with Aplastic Anemia Open Access

Narita, A; Zhu, XF; Muramatsu, H; Chen, XJ; Guo, Y; Yang, WY; Zhang, JL; Liu, F; Jang, JH; Kook, H; Kim, H; Usuki, K; Yamazaki, H; Takahashi, Y; Nakao, S; Lee, JW; Kojima, S

BLOOD Vol. 132 2018.11

The Presence of Defective Epstein-Barr Virus (EBV) Infection in Patients with EBV-Associated Hematological Malignancy

Okuno Yusuke, Murata Takayuki, Sato Yoshitaka, Muramatsu Hideki, Ito Yoshinori, Watanabe Takahiro, Okuno Tatsuya, Murakami Norihiro, Yoshida Kenichi, Sawada Akihisa, Inoue Masami, Kawa Keisei, Seto Masao, Ohshima Koichi, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Narita Yohei, Yoshida Masahiro, Goshima Fumi, Kawada Junichi, Nishida Tetsuya, Kiyoi Hitoshi, Kato Seiichi, Nakamura Shigeo, Morishima Satoko, Fujiwara Shigeyoshi, Shimizu Norio, Isobe Yasushi, Noguchi Masaaki, Kikuta Atsushi, Iwatsuki Keiji, Takahashi Yoshiyuki, Kojima Seiji, Ogawa Seishi, Kimura Hiroshi

BLOOD Vol. 132 2018.11

Application of RNA Sequencing for Early Diagnosis of NUT Carcinoma: A Case Report

Miwata Shunsuke, Narita Atsushi, Wakamatsu Manabu, Narita Kotaro, Kitazawa Hironobu, Kataoka Shinsuke, Hamada Motoharu, Murakami Norihiro, Taniguchi Rieko, Ichikawa Daisuke, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Okuno Yusuke, Nishio Nobuhiro, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

PEDIATRIC BLOOD & CANCER Vol. 65 page： S74 - S74 2018.11

A Case of Thoracic Tumor Caused by SMARCA4 Biallelic Inactivation

Ichikawa Daisuke, Muramatsu Hideki, Okuno Yusuke, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Kitazawa Hironobu, Hamada Motoharu, Kataoka Shinsuke, Taniguchi Rieko, Murakami Norihiro, Suzuki Kyogo, Nishikawa Eri, Kawashima Nozomu, Narita Atsushi, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

PEDIATRIC BLOOD & CANCER Vol. 65 page： S74 - S74 2018.11

A Case of MLL-AF9 Fusion Positive Malignant Lymphoma Without Bone Marrow Infiltration Either at First Diagnosis or at Relapse

Narita Kotaro, Kataoka Shinsuke, Hamada Motoharu, Ichikawa Daisuke, Taniguchi Rieko, Murakami Norihiro, Suzuki Kyogo, Nishikawa Eri, Nishio Nobuhiro, Okuno Yusuke, Kawashima Nozomu, Narita Atsushi, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

PEDIATRIC BLOOD & CANCER Vol. 65 page： S99 - S99 2018.11

A Case of Dyskeratosis Congenital who Showed the Improvement of Telomere Length After Receiving Androgens for 11 Years

Wakamatsu Manabu, Nishio Nobuhiro, Miwata Shunsuke, Narita Kotaro, Kitazawa Hironobu, Kataoka Shinsuke, Hamada Motoharu, Murakami Norihiro, Ichikawa Daisuke, Taniguchi Rieko, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Okuno Yusuke, Narita Atsushi, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

PEDIATRIC BLOOD & CANCER Vol. 65 page： S65 - S65 2018.11

Diagnosis of Inherited Bone Marrow Failure Syndromes Using Sequencing Approaches

Narita, A; Muramatsu, H; Okuno, Y; Yoshida, K; Shiraishi, Y; Sakaguchi, H; Kawashima, N; Wang, XA; Xu, YY; Chiba, K; Tanaka, H; Hama, A; Sanada, M; Hitoshi, K; Yamaguchi, H; Ohga, S; Manabe, A; Harigae, H; Kunishima, S; Ishii, E; Kobayashi, M; Koike, K; Watanabe, K; Ito, E; Takata, M; Yabe, M; Ogawa, S; Miyano, S; Kojima, S; Takahashi, Y

PEDIATRIC BLOOD & CANCER Vol. 65 page： S7 - S7 2018.11

Disappearance of Minimal Residual Disease Demonstrates Graft Versus Neuroblastoma Effect After KIR-Ligand Mismatched Allogeneic Cord Blood Transplantation

Nishio, N; Kataoka, S; Miwata, S; Narita, K; Kitazawa, H; Hamada, M; Ichikawa, D; Taniguchi, R; Murakami, N; Suzuki, K; Kawashima, N; Nishikawa, E; Okuno, Y; Narita, A; Muramatsu, H; Kojima, S; Takahashi, Y

PEDIATRIC BLOOD & CANCER Vol. 65 page： S8 - S8 2018.11

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Papers - TAKAHASHI, Yoshiyuki