Faculty Profiles - TAKAHASHI, Yoshiyuki

Papers - TAKAHASHI, Yoshiyuki

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Conditioning Regimen for Allogeneic Bone Marrow Transplantation in Children With Acquired Bone Marrow Failure: Fludarabine/Melphalan vs. Fludarabine/Cyclophosphamide

Yoshida, N; Takahashi, Y; Yabe, H; Kobayashi, R; Watanabe, K; Kudo, K; Yabe, M; Miyamura, T; Koh, K; Kawaguchi, H; Goto, H; Fujita, N; Hara, J; Okamoto, Y; Kato, K; Inoue, M; Suzuki, R; Atsuta, Y; Kojima, S

PEDIATRIC BLOOD & CANCER Vol. 66 page： S95 - S95 2019.12

Integrating FANCD2 Functional Analysis With High-Throughput Sequencing for Diagnosing Fanconi Anemia

Nozomu Kawashima, Yusuke Okuno, Hideki Muramatsu, Rieko Taniguchi, Taro Yoshida, Masayuki Imaya, Ayako Yamamori, Manabu Wakamatsu, Shunsuke Miwata, Kotaro Narita, Motoharu Hamada, Daisuke Ichikawa, Nobuhiro Kitazawa, Eri Nishikawa, Atsushi Narita, Nobuhiro Nishio, Seiji Kojima, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S44 - S45 2019.12

Induction of Partial Response With Ceritinib for a Child With Chemotherapy-Refractory ALK-rearranged Neuroblastoma

Kotaro Narita, Taro Yoshida, Ayako Yamamori, Manabu Wakamatsu, Masayuki Imaya, Shunsuke Miwata, Hironobu Kitazawa, Rieko Taniguchi, Daisuke Ichikawa, Motoharu Hamada, Eri Nishikawa, Nobuhiro Nishio, Yusuke Okuno, Nozomu Kawashima, Atsushi Narita, Hideki Muramatsu, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S104 - S104 2019.12

Correlation Between Plasma Rabbit Anti-Thymocyte Globulin Level and Response to Immunosuppressive Therapy in Patients With Severe Aplastic Anemia

Atsushi Narita, Hideki Muramatsu, Motoharu Hamada, Daisuke Ichikawa, Eri Nishikawa, Nozomu Kawashima, Yusuke Okuno, Nobuhiro Nishio, Hirohito Yamazaki, Shinji Nakao, Seiji Kojima, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S45 - S45 2019.12

Genetic Diagnosis Based on a Comprehensive Fusion Gene Analysis of Pediatric Malignant Solid Tumors

Daisuke Ichikawa, Hideki Muramatsu, Yusuke Okuno, Motoharu Hamada, Rieko Taniguchi, Eri Nishikawa, Nozomu Kawashima, Atsushi Narita, Nobuhiro Nishio, Yoshie Shimoyama, Masato Nakaguro, Shigeo Nakamura, Seiji Kojima, Atsuko Nakazawa, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S61 - S61 2019.12

Evaluation of the Outcome of KIR-Ligand Mismatched Cord Blood Transplantation for High Risk Metastatic Neuroblastoma Using New SIOPEN Risk Stratification

Nobuhiro Nishio, Daisuke Ichikawa, Manabu Wakamatsu, Kotaro Narita, Shunsuke Miwata, Hironobu Kitazawa, Rieko Taniguchi, Motoharu Hamada, Eri Nishikawa, Nozomu Kawashima, Yusuke Okuno, Atsushi Narita, Hideki Muramatsu, Seiji Kojima, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S106 - S106 2019.12

Two Cases Effectively Treated with Oral Budesonide Administration for Steroid-resistant Intestinal Acute Graft Versus Host Disease

Ayako Yamamori, Eri Nishikawa, Atsushi Narita, Masayuki Imaya, Manabu Wakamatsu, Taro Yoshida, Shunsuke Miwata, Hironobu Kitazawa, Kotaro Narita, Rieko Taniguchi, Daisuke Ichikawa, Motoharu Hamada, Nozomu Kawashima, Yusuke Okuno, Nobuhiro Nishio, Hideki Muramatsu, Seiji Kojima, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S37 - S38 2019.12

Whole Exome Sequencing Contributes to Genetic Diagnosis of IBMFS Patients

Hideki Muramatsu, Motoharu Hamada, Yusuke Okuno, Manabu Wakamatsu, Rieko Taniguchi, Koutarou Narita, Nozomu Kawashima, Hironobu Kitazawa, Daisuke Ichikawa, Eri Nishikawa, Nazomu Kawashima, Atsushi Narita, Nobuhiro Nishio, Seiji Kojima, Tomoo Ogi, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S63 - S64 2019.12

Prediction of postnatal clinical course in primary congenital dilated cardiomyopathy. Reviewed International journal

Hidenori Yamamoto, Yoshie Fukasawa, Naoki Ohashi, Takehiko Yokoyama, Kazutaka Suzuki, Takaya Ota, Kazushi Yasuda, Kentaro Omoya, Yoshiyuki Takahashi, Taichi Kato

Pediatrics international : official journal of the Japan Pediatric Society Vol. 61 ( 12 ) page： 1196 - 1201 2019.12

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The aim of this study was to investigate the prediction of postnatal prognosis using fetal and perinatal data in patients with primary congenital dilated cardiomyopathy (PCDCM), and to estimate the incidence of this disease. METHODS: We examined correlations between fetal or perinatal data and postnatal clinical course in a multicenter retrospective study of eight patients with PCDCM. Incidence was calculated in a population-based study. RESULTS: All patients developed heart failure at a median of 8 days (range, 0-43 days), and six patients died or required extracorporeal artificial heart therapy at a median of 67 days (range, 0-92 days). The cardiothoracic area ratio from fetal echocardiography, the Apgar score, and the standard deviation of birth weight correlated significantly with the date at onset of heart failure. However, no data correlated with survival. Cumulative incidence of PCDCM was calculated as 1.21 per 100 000 total births (95% confidence interval, 0.37 to 2.06). CONCLUSIONS: Primary congenital dilated cardiomyopathy has a poor prognosis, but cardiothoracic area ratio from fetal echocardiography, body weight at birth, and Apgar score correlate with the timing of the onset of heart failure, and these indicators might therefore be useful for peri- and postnatal management.

DOI： 10.1111/ped.14029

Web of Science

PubMed

Successful Treatment of Central Nervous System Relapses of Neuroblastoma Stage 4 After a KIR-ligand Mismatched Allogeneic Cord Blood Transplantation

Masayuki Imaya, Atsushi Narita, Taro Yoshida, Ayako Yamamori, Manabu Wakamatsu, Syunsuke Miwata, Kotaro Narita, Hironobu Kitazawa, Rieko Taniguchi, Daisuke Ichikawa, Motoharu Hamada, Eri Nishikawa, Nozomu Kawashima, Hideki Muramatsu, Nobuhiro Nishio, Seiji Kojima, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S102 - S102 2019.12

Successfully Treated Three Children With Pericardial Effusion After Hematopoietic Stem Cell Transplantation

Hironobu Kitazawa, Atsushi Narita, Taro Yoshida, Masayuki Imaya, Ayako Yamamori, Manabu Wakamatsu, Shunsuke Miwata, Kotaro Narita, Rieko Taniguchi, Motoharu Hamada, Daisuke Ichikawa, Eri Nishikawa, Nozomu Kawashima, Yusuke Okuno, Nobuhiro Nishio, Hideki Muramatsu, Seiji Kojima, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S97 - S97 2019.12

Comprehensive Mutational Analysis of Juvenile Myelomonocytic Leukemia Using Whole-Genome Sequencing Open Access

Yusuke Okuno, Hideki Muramatsu, Norihiro Murakami, Nozomu Kawashima, Manabu Wakamatsu, Hironobu Kitazawa, Tomoo Ogi, Yoshiyuki Takahashi

BLOOD Vol. 134 2019.11

Detection of Subclonal <i>SETBP1</i> and <i>JAK3</i> Mutations in Patients with Juvenile Myelomonocytic Leukemia Using Droplet Digital PCR Open Access

Wakamatsu, M; Muramatsu, H; Murakami, N; Okuno, Y; Kitazawa, H; Kojima, S; Takahashi, Y

BLOOD Vol. 134 2019.11

High Natural Killer Cell Count at Diagnosis Predicts a Good Response to Immunosuppressive Therapy in Aplastic Anemia

Atsushi Narita, Hideki Muramatsu, Yinyan Xu, Motoharu Hamada, Daisuke Ichikawa, Eri Nishikawa, Nozomu Kawashima, Yusuke Okuno, Nobuhiro Nishio, Hirohito Yamazaki, Shinji Nakao, Seiji Kojima, Yoshiyuki Takahashi

BLOOD Vol. 134 2019.11

Genome-Wide Methylation Analysis Using the Digital Restriction Enzyme Analysis of Methylation for Stratification of Patients with Juvenile Myelomonocytic Leukemia Open Access

Hironobu Kitazawa, Hideki Muramatsu, Norihiro Murakami, Yusuke Okuno, Manabu Wakamatsu, Taro Yoshida, Masayuki Imaya, Ayako Yamamori, Shunsuke Miwata, Kotaro Narita, Motoharu Hamada, Daisuke Ichikawa, Rieko Taniguchi, Nozomu Kawashima, Eri Nishikawa, Atsushi Narita, Nobuhiro Nishio, Seiji Kojima, Yoshiyuki Takahashi

BLOOD Vol. 134 2019.11

DNA Methylation As a Biomarker of Outcome in JMML: An International Effort Towards Clinical Implementation

Meyer, J; Schönung, M; Flotho, C; Olshen, AB; Hartmann, M; Plass, C; Okuno, Y; Takahashi, Y; Murakami, N; Wakamatsu, M; Loh, ML; Niemeyer, CM; Muramatsu, H; Lipka, DB; Stieglitz, E

BLOOD Vol. 134 2019.11

Utility of Newborn Screening for Severe Combined Immunodeficiency and X-Linked Agammaglobulinemia Using TREC and KREC Assays Open Access

Wakamatsu, M; Muramatsu, H; Kataoka, S; Okuno, Y; Yoshimi, S; Nakajima, Y; Ito, T; Tsuge, I; Kojima, S; Takahashi, Y

BLOOD Vol. 134 2019.11

Phase I Study of Cord Blood Transplantation with Intra-Bone Marrow Injection of Mesenchymal Stem Cells

Goto, T; Murata, M; Nishida, T; Terakura, S; Kamoshita, S; Ishikawa, Y; Ushijima, Y; Adachi, Y; Kato, K; Hirakawa, A; Nishiwaki, S; Nishio, N; Takahashi, Y; Kodera, Y; Matsushita, T; Kiyoi, H

BLOOD Vol. 134 2019.11

Corrigendum to "Frequent intragenic microdeletions of elastin in familial supravalvular aortic stenosis." [Int. J. Cardiol., 274 (2019) 290-295]. Reviewed International journal Open Access

Satoshi Hayano, Yusuke Okuno, Makiko Tsutsumi, Hidehito Inagaki, Yoshie Fukasawa, Hiroki Kurahashi, Seiji Kojima, Yoshiyuki Takahashi, Taichi Kato

International journal of cardiology Vol. 292 page： 283 - 283 2019.10

Prospective randomized trial comparing two doses of rabbit anti-thymocyte globulin in patients with severe aplastic anaemia. Reviewed International journal Open Access

Atsushi Narita, Xiaofan Zhu, Hideki Muramatsu, Xiaojuan Chen, Ye Guo, Wenyu Yang, Jingliao Zhang, Fang Liu, Jun H Jang, Hoon Kook, Hawk Kim, Kensuke Usuki, Hirohito Yamazaki, Yoshiyuki Takahashi, Shinji Nakao, Jong Wook Lee, Seiji Kojima

British journal of haematology Vol. 187 ( 2 ) page： 227 - 237 2019.10

Language：English Publishing type：Research paper (scientific journal)

The treatment of choice for patients with severe aplastic anaemia (SAA) includes immunosuppressive therapy (IST) with anti-thymocyte globulin (ATG) and ciclosporin A. However, the optimal dose for rabbit ATG has yet to be established. We herein report the first prospective, randomized, multicentre study comparing two doses of rabbit ATG in patients with SAA. Patients with SAA who required initial IST in Japan (n = 89), China (n = 85) and Korea (n = 48) were enrolled between May 2012 and October 2017. A 1:1 block randomization was employed for two doses of rabbit ATG. In total, 222 patients were randomized, with 112 patients receiving 2·5 mg/kg and 110 receiving 3·5 mg/kg of rabbit ATG for 5 days. The primary endpoint was the haematological response at day 180. After 6 months, no significant difference in response rates was observed between the 2·5 and 3·5 mg/kg groups (49% vs. 48%, P = 0·894). Overall survival at 3 years was similar between the two groups [85% (95% confidence interval [CI], 76%-91%) vs. 91% (95% CI, 82%-96%); P = 0·107]. The current study revealed no significant differences in the efficacy and safety between the 2·5 and 3·5 mg/kg doses of rabbit ATG in patients with SAA. Trial registration: UMIN000011134.

DOI： 10.1111/bjh.16055

Web of Science

PubMed

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Papers - TAKAHASHI, Yoshiyuki