Faculty Profiles - TAKAHASHI, Yoshiyuki

Papers - TAKAHASHI, Yoshiyuki

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蛋白同化ステロイド内服を11年継続している先天性角化不全症の一例(A case of dyskeratosis congenital who showed the improvement of telomere length after receiving androgens for 11 years)

Wakamatsu Manabu, Nishio Nobuhiro, Miwata Shunsuke, Narita Kotaro, Kitazawa Hironobu, Kataoka Shinsuke, Hamada Motoharu, Murakami Norihiro, Ichikawa Daisuke, Taniguchi Rieko, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Okuno Yusuke, Narita Atsushi, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 55 ( 4 ) page： 246 - 246 2018.10

小児再生不良性貧血に対するUpfront移植を含むハプロ移植の7例(Urgent successful HLA-haploidentical stem cell transplantation in children with aplastic anemia considering upfront SCT strategy)

Nishikawa Eri, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Murakami Norihiro, Kataoka Shinsuke, Hamada Motoharu, Ichikawa Daisuke, Kitazawa Hironobu, Taniguchi Rieko, Suzuki Kyogo, Kawashima Nozomu, Okuno Yusuke, Narita Atsushi, Muramatsu Hideki, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 55 ( 4 ) page： 247 - 247 2018.10

シーケンスによる先天性骨髄不全症の診断(Diagnosis of Inherited Bone Marrow Failure Syndromes Using Sequencing Approaches)

Narita Atsushi, Muramatsu Hideki, Okuno Yusuke, Yoshida Kenichi, Shiraishi Yuichi, Sakaguchi Hirotoshi, Kawashima Nozomu, Wang Xinan, Xu Yinyan, Chiba Kenichi, Tanaka Hiroko, Hama Asahito, Sanada Masashi, Kanno Hitoshi, Yamaguchi Hiroki, Ohga Shouichi, Manabe Atsushi, Harigae Hideo, Kunishima Shinji, Ishii Eiichi, Kobayashi Masao, Koike Kenichi, Watanabe Kenichiro, Ito Etsuro, Takata Minoru, Yabe Miharu, Ogawa Seishi, Miyano Satoru, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 55 ( 4 ) page： 153 - 153 2018.10

初発時および再発時に骨髄浸潤を認めなかったMLL/AF9融合遺伝子を持つ悪性リンパ腫の1例(A case of MLL-AF9 fusion positive malignant lymphoma without bone marrow infiltration either at first diagnosis or at relapse)

Narita Kotaro, Kataoka Shinsuke, Hamada Motoharu, Ichikawa Daisuke, Taniguchi Rieko, Murakami Norihiro, Suzuki Kyogo, Nishikawa Eri, Nishio Nobuhiro, Okuno Yusuke, Kawashima Nozomu, Narita Atsushi, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 55 ( 4 ) page： 316 - 316 2018.10

小児がん拠点病院単一施設における漢方診療の患者ニーズ調査(Unmet medical needs for Japanese Kampo medicine in children with hematological and oncological disease)

Kawashima Nozomu, Miwata Shunsuke, Narita Kotaro, Kataoka Shinsuke, Hamada Motoharu, Murakami Norihiro, Ichikawa Daisuke, Suzuki Kyogo, Kitazawa Hironobu, Nishikawa Eri, Okuno Yusuke, Taniguchi Rieko, Narita Atsushi, Muramatsu Hideki, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 55 ( 4 ) page： 219 - 219 2018.10

SMARCA4の不活化変異により発症した胸部腫瘍の1例(A case of thoracic tumor caused by SMARCA4 biallelic inactivation)

Ichikawa Daisuke, Muramatsu Hideki, Okuno Yusuke, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Kitazawa Hironobu, Hamada Motoharu, Kataoka Shinsuke, Taniguchi Rieko, Murakami Norihiro, Suzuki Kyogo, Nishikawa Eri, Kawashima Nozomu, Narita Atsushi, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 55 ( 4 ) page： 255 - 255 2018.10

RNAシーケンスが早期診断に有用であったNUT carcinomaの1例(Application of RNA sequencing for early diagnosis of NUT carcinoma: a case report)

Miwata Shunsuke, Narita Atsushi, Wakamatsu Manabu, Narita Kotaro, Kitazawa Hironobu, Kataoka Shinsuke, Hamada Motoharu, Murakami Norihiro, Taniguchi Rieko, Ichikawa Daisuke, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Okuno Yusuke, Nishio Nobuhiro, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 55 ( 4 ) page： 255 - 255 2018.10

DREAM法を用いた若年性骨髄単球性白血病に対するメチル化解析(NGS-based methylation analysis of juvenile myelomonocytic leukemia using the digital restriction enzyme analysis of methylation(DREAM) method)

Kitazawa Hironobu, Murakami Norihiro, Okuno Yusuke, Muramatsu Hideki, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Kataoka Shinsuke, Hamada Motoharu, Ichikawa Daisuke, Taniguchi Rieko, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Narita Atsushi, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

日本小児血液・がん学会雑誌 Vol. 55 ( 4 ) page： 206 - 206 2018.10

Defibrotide for Prophylaxis of Hepatic Veno-Occlusive Disease Hematopoietic Stem Cell Transplantation: Results from the Japanese Prophylactic Use, Phase II, Randomized Trial

Kikuta, A; Fukuda, T; Ohashi, K; Taniguchi, S; Asano-Mori, Y; Horibe, K; Goto, H; Nakamae, H; Ogawa, H; Tamaki, H; Takahashi, Y; Kimura, T; Yoshimura, K; Umemura, K; Ogawa, C

BONE MARROW TRANSPLANTATION Vol. 53 page： 316 - 317 2018.9

Defibrotide for Treatment of Hepatic Veno-Occlusive Disease Following Hematopoietic Stem Cell Transplantation: Results from the Japanese Therapeutic Use Protocol

Kikuta, A; Fukuda, T; Ohashi, K; Taniguchi, S; Asano-Mori, Y; Horibe, K; Goto, H; Nakamae, H; Ogawa, H; Tamaki, H; Takahashi, Y; Kimura, T; Yoshimura, K; Umemura, K; Ogawa, C

BONE MARROW TRANSPLANTATION Vol. 53 page： 318 - 319 2018.9

Updated Treatment Algorism for Children with Acquired Aplastic Anemia: A Report from the Japan Childhood Aplastic Anemia Study Group

Yoshida, N; Narita, A; Muramatsu, H; Kobayashi, R; Yabe, H; Kudo, K; Yagasaki, H; Watanabe, K; Morimoto, A; Ito, E; Ohga, S; Ohara, A; Takahashi, Y; Kojima, S

BONE MARROW TRANSPLANTATION Vol. 53 page： 34 - 35 2018.9

Whole-exome analysis to detect congenital hemolytic anemia mimicking congenital dyserythropoietic anemia. Reviewed

Motoharu Hamada, Sayoko Doisaki, Yusuke Okuno, Hideki Muramatsu, Asahito Hama, Nozomu Kawashima, Atsushi Narita, Nobuhiro Nishio, Kenichi Yoshida, Hitoshi Kanno, Atsushi Manabe, Takashi Taga, Yoshiyuki Takahashi, Satoru Miyano, Seishi Ogawa, Seiji Kojima

International journal of hematology Vol. 108 ( 3 ) page： 306 - 311 2018.9

Language：English Publishing type：Research paper (scientific journal)

Congenital dyserythropoietic anemia (CDA) is a heterogeneous group of rare congenital disorders characterized by ineffective erythropoiesis and dysplastic changes in erythroblasts. Diagnosis of CDA is based primarily on the morphology of bone marrow erythroblasts; however, genetic tests have recently become more important. Here, we performed genetic analysis of 10 Japanese patients who had been diagnosed with CDA based on laboratory findings and morphological characteristics. We examined 10 CDA patients via central review of bone marrow morphology and genetic analysis for congenital bone marrow failure syndromes. Sanger sequencing for CDAN1, SEC23B, and KLF1 was performed for all patients. We performed whole-exome sequencing in patients without mutation in these genes. Three patients carried pathogenic CDAN1 mutations, whereas no SEC23B mutations were identified in our cohort. WES unexpectedly identified gene mutations known to cause congenital hemolytic anemia in two patients: canonical G6PD p.Val394Leu mutation and SPTA1 p.Arg28His mutation. Comprehensive genetic analysis is warranted for more effective diagnosis of patients with suspected CDA.

DOI： 10.1007/s12185-018-2482-7

Web of Science

PubMed

Risk Factors for Viral Infections in Pediatric Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Narita, A; Ito, Y; Torii, Y; Kawada, JI; Miwata, S; Narita, K; Kitazawa, H; Hamada, M; Kataoka, S; Ichikawa, D; Ito, R; Murakami, N; Kojima, D; Suzuki, K; Nishikawa, E; Kawashima, N; Okuno, Y; Muramatsu, H; Hama, A; Kojima, S; Takahashi, Y

BONE MARROW TRANSPLANTATION Vol. 53 page： 588 - 589 2018.9

Serum anti-<i>Helicobacter pylori</i> antibody titer and its association with gastric nodularity, atrophy, and age: A cross-sectional study. Reviewed International journal Open Access

Toyoshima O, Nishizawa T, Sakitani K, Yamakawa T, Takahashi Y, Yamamichi N, Hata K, Seto Y, Koike K, Watanabe H, Suzuki H

World journal of gastroenterology Vol. 24 ( 35 ) page： 4061 - 4068 2018.9

Language：English Publishing type：Research paper (scientific journal)

AIM: To clarify the role of serum anti-Helicobacter pylori (H. pylori) antibody titers in gastric cancer. METHODS: In this cross-sectional study, the effect of patients' baseline characteristics and endoscopic findings on their serum antibody titers were assessed. We evaluated consecutive patients who underwent esophagogastroduodenoscopy and their first evaluation for H. pylori infection using a serum antibody test. We excluded patients with a history of eradication therapy. The participants were divided into four groups according to their E-plate serum antibody titer. Patients with serum antibody titers < 3, 3-9.9, 10-49.9, and ≥ 50 U/mL were classified into groups A, B, C, and D, respectively. RESULTS: In total, 874 participants were analyzed with 70%, 16%, 8.7%, and 5.1% of them in the groups A, B, C, and D, respectively. Patients in group C were older than patients in groups A and B. Gastric open-type atrophy, intestinal metaplasia, enlarged folds, diffuse redness, and duodenal ulcers were associated with a high titer. Regular arrangements of collecting venules, fundic gland polyps, superficial gastritis, and gastroesophageal reflux disease were related to a low titer. Multivariate analysis revealed that nodularity (P = 0.0094), atrophy (P = 0.0076), and age 40-59 years (vs age ≥ 60 years, P = 0.0090) were correlated with a high serum antibody titer in H. pylori-infected patients. Intestinal metaplasia and atrophy were related to age ≥ 60 years in group C and D. CONCLUSION: Serum antibody titer changes with age, reflects gastric mucosal inflammation, and is useful in predicting the risk of gastric cancer.

DOI： 10.3748/wjg.v24.i35.4061

Open Access

PubMed

Risk Factors for Viral Infections in Pediatric Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Narita Atsushi, Ito Yoshinori, Torii Yuka, Kawada Jun-Ichi, Miwata Shunsuke, Narita Kotaro, Kitazawa Hironobu, Hamada Motoharu, Kataoka Shinsuke, Ichikawa Daisuke, Ito Rieko, Murakami Norihiro, Kojima Daiei, Suzuki Kyogo, Nishikawa Eri, Kawashima Nozomu, Okuno Yusuke, Muramatsu Hideki, Hama Asahito, Kojima Seiji, Takahashi Yoshiyuki

BONE MARROW TRANSPLANTATION Vol. 53 page： 588-589 2018.9

Integration Mapping of piggyBac-Mediated CD19 Chimeric Antigen Receptor T Cells Analyzed by Novel Tagmentation-Assisted PCR. Reviewed International journal Open Access

Motoharu Hamada, Nobuhiro Nishio, Yusuke Okuno, Satoshi Suzuki, Nozomu Kawashima, Hideki Muramatsu, Shoma Tsubota, Matthew H Wilson, Daisuke Morita, Shinsuke Kataoka, Daisuke Ichikawa, Norihiro Murakami, Rieko Taniguchi, Kyogo Suzuki, Daiei Kojima, Yuko Sekiya, Eri Nishikawa, Atsushi Narita, Asahito Hama, Seiji Kojima, Yozo Nakazawa, Yoshiyuki Takahashi

EBioMedicine Vol. 34 page： 18 - 26 2018.8

Language：English Publishing type：Research paper (scientific journal)

Insertional mutagenesis is an important risk with all genetically modified cell therapies, including chimeric antigen receptor (CAR)-T cell therapy used for hematological malignancies. Here we describe a new tagmentation-assisted PCR (tag-PCR) system that can determine the integration sites of transgenes without using restriction enzyme digestion (which can potentially bias the detection) and allows library preparation in fewer steps than with other methods. Using this system, we compared the integration sites of CD19-specific CAR genes in final T cell products generated by retrovirus-based and lentivirus-based gene transfer and by the piggyBac transposon system. The piggyBac system demonstrated lower preference than the retroviral system for integration near transcriptional start sites and CpG islands and higher preference than the lentiviral system for integration into genomic safe harbors. Integration into or near proto-oncogenes was similar in all three systems. Tag-PCR mapping is a useful technique for assessing the risk of insertional mutagenesis.

DOI： 10.1016/j.ebiom.2018.07.008

Open Access

Web of Science

PubMed

Late-phase human herpesvirus 6B reactivation in hematopoietic stem cell transplant recipients. Reviewed International journal

Hiroki Miura, Yoshiki Kawamura, Fumihiko Hattori, Makito Tanaka, Kazuko Kudo, Masaru Ihira, Hiroshi Yatsuya, Yoshiyuki Takahashi, Seiji Kojima, Tetsushi Yoshikawa

Transplant infectious disease : an official journal of the Transplantation Society Vol. 20 ( 4 ) page： e12916 2018.8

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: We sought to determine whether late-phase human herpesvirus 6B (HHV-6B) infection in hematopoietic stem cell transplant (HSCT) recipients was associated with serious outcomes and mortality. METHODS: The occurrence and course of HHV-6B infection was monitored for at least 60 days after transplant using virus isolation and real-time polymerase chain reaction. Risk factors for late-phase HHV-6B infection were examined, and the propensity score was calculated with significant risk factors. The inverse probability-weighted multivariable logistic regression analysis was performed to estimate odds ratios (ORs) and the 95% confidence intervals (95% CI) for mortality. RESULTS: Late-phase HHV-6B infection was observed in 12/89 (13.5%) of the HSCT recipients. Older age (OR: 10.3, 95% CI: 2.1/72.9, P = .0027), hematologic malignancy (OR: 10.3, 95% CI: 1.8/97.1, P = .0063), unrelated donor transplantation (OR: 5.3, 95% CI: 1.1/36.0, P = .0345), and sex-mismatched donor transplantation (OR: 6.3, 95% CI: 1.4/39.5, P = .0149) were identified as risk factors for late-phase HHV-6B infection. Fifteen subjects died (17%). Inverse probability-weighted multivariable logistic model analysis revealed that late-phase HHV-6B infection was an independent risk factor for mortality (OR: 4.2, 95% CI: 1.7/11.0, P = .0012). Among 5 of the fatal cases of late-phase HHV-6B infection, viral infection might be associated with severe clinical manifestations. CONCLUSION: Late-phase HHV-6B infection in HSCT recipients was associated with worse outcomes. The full spectrum of clinical features of the infection has not been fully elucidated, and therefore, recipients with high-risk factors for late-phase HHV-6B infection should be carefully monitored.

DOI： 10.1111/tid.12916

Web of Science

PubMed

Expression and localization of aquaporins 3 and 7 in bull spermatozoa and their relevance to sperm motility after cryopreservation. Reviewed Open Access

Fujii T, Hirayama H, Fukuda S, Kageyama S, Naito A, Yoshino H, Moriyasu S, Yamazaki T, Sakamoto K, Hayakawa H, Takahashi K, Takahashi Y, Sawai K

The Journal of reproduction and development Vol. 64 ( 4 ) page： 327 - 335 2018.8

Language：English Publishing type：Research paper (scientific journal)

Artificial insemination with cryopreserved semen is a well-developed technique commonly used for controlled reproduction in cattle. However, despite current technical advances, cryopreservation continues to damage bull spermatozoa, resulting in a loss of approximately 30 to 50% of viable spermatozoa post thawing. To further improve the efficiency of cryopreservation of bull spermatozoa, understanding the molecular mechanisms underlying the cryobiological properties that affect cryoinjuries during cryopreservation process of bull spermatozoa is required. In this study, we examined the expression and localization of aquaporin (AQP) 3 and AQP7 in fresh, cooled, and frozen-thawed bull spermatozoa. Furthermore, we investigated the relevance of AQP3 and AQP7 to motility and to membrane integrity in frozen-thawed bull spermatozoa. Western blotting against AQP3 and AQP7 in bull spermatozoa revealed bands with molecular weights of approximately 42 kDa and 53 kDa, respectively. In immunocytochemistry analyses, immunostaining of AQP3 was clearly observed in the principal piece of the sperm tail. Two immunostaining patterns were observed for AQP7 -pattern 1: diffuse staining in head and entire tail, and pattern 2: diffuse staining in head and clear staining in mid-piece. Cooling and freeze-thawing did not affect the localization pattern of AQP7 and the relative abundances of AQP3 and AQP7 evaluated by Western blotting. Furthermore, we demonstrated that the relative abundances of AQP3 and AQP7 varied among ejaculates, and they were positively related to sperm motility, particularly sperm velocity, post freeze-thawing. Our findings suggest that AQP3 and AQP7 are possibly involved in the tolerance to freeze-thawing in bull spermatozoa, particularly in the sperm's tail.

DOI： 10.1262/jrd.2017-166

Open Access

PubMed

小児循環器疾患の基礎研究から臨床への応用家族性大動脈弁上狭窄において、遺伝子内微小欠失の頻度は高い次世代シーケンサーによる7家系の解析と臨床応用への可能性

早野聡, 奥野友介, 堤真紀子, 稲垣秀人, 深澤佳絵, 倉橋浩樹, 小島勢二, 高橋義行, 加藤太一

日本小児循環器学会雑誌 Vol. 34 ( Suppl.1 ) page： s1 - 122 2018.7

冠動脈病変合併リスクの高い川崎病患者に対する投与期間を短縮した免疫グロブリン・プレドニゾロン初期併用療法多施設共同ランダム化比較試験による検証

加藤太一, 深澤佳絵, 山本英範, 沼口敦, 早野聡, 岸本泰明, 長井典子, 安藤昌彦, 高橋義行

日本小児循環器学会雑誌 Vol. 34 ( Suppl.1 ) page： s1 - 283 2018.7

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Papers - TAKAHASHI, Yoshiyuki