Faculty Profiles - TAKAHASHI, Yoshiyuki

Papers - TAKAHASHI, Yoshiyuki

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A Novel Treatment with Stem Cells from Human Exfoliated Deciduous Teeth for Hypoxic-Ischemic Encephalopathy in Neonatal Rats. Reviewed International journal

Yuma Kitase, Yoshiaki Sato, Kazuto Ueda, Toshihiko Suzuki, Alkisti Mikrogeorgiou, Yuichiro Sugiyama, Kohki Matsubara, Yuka Tsukagoshi Okabe, Shinobu Shimizu, Hitoshi Hirata, Hiroshi Yukawa, Yoshinobu Baba, Masahiro Tsuji, Yoshiyuki Takahashi, Akihito Yamamoto, Masahiro Hayakawa

Stem cells and development Vol. 29 ( 2 ) page： 63 - 74 2020.1

Language：English Publishing type：Research paper (scientific journal)

Recently, cell therapy has been developed as a novel treatment for perinatal hypoxic-ischemic encephalopathy (HIE), which is an important cause of neurological disorder and death, and stem cells from human exfoliated deciduous teeth (SHED) express early markers for mesenchymal and neuroectodermal stem cells. We investigated the treatment effect of SHED for HIE in neonatal rats. Seven-day-old rats underwent ligation of the left carotid artery and were exposed to 8% hypoxic treatment. SHED (1 × 105 cells) were injected via the right external jugular vein 24 h after the insult. The effect of intravenous administration of SHED cells was evaluated neurologically and pathophysiologically. In the evaluation of engraftment using quantum dots 655, only a few SHED were detected in the injured cortex. In the immunohistological evaluation 24 h after injection, the numbers of positive cells of active caspase-3 and anti-4 hydroxynonenal antiserum were lower in the SHED group than in the vehicle group. The number of Iba-1+ cells in the cortex was higher in the SHED group. However, the proportion of M1 microglia (Iba-1+/ED-1+) was significantly decreased, whereas M2 microglia (Iba-1+/CD206+) tended to increase in the SHED group. In the behavioral tests performed 5 months after hypoxic treatment, compared to the vehicle group, the SHED group showed significant elongation of the endurance time in the rotarod treadmill test, significantly ameliorated proportion of using the impaired hand in the cylinder test, significantly lower ratio of right/left front paw area in gait analysis, and significantly higher avoidance rate in the active avoidance test. In the in vitro experiment with cultured neurons exposed to oxygen-glucose deprivation, we confirmed the neuroprotective effect of the condition medium of SHED. These results suggested that intravenous administration of SHED exerted a treatment effect both histologically and functionally, possibly via a paracrine effect.

DOI： 10.1089/scd.2019.0221

Web of Science

PubMed

A Case of a 14-Year-Old Boy who had Difficulty Walking Due to Drug-Induced Neuropathy During T-Cell Acute Lymphocytic Leukemia Treatment

Taro Yoshida, Aya Sawamura, Hideki Muramatsu, Masayuki Imaya, Ayako Yamamori, Manabu Wakamatsu, Shunsuke Miwata, Kotaro Narita, Hironobu Kitazawa, Rieko Taniguchi, Daisuke Ichikawa, Eri Nishikawa, Motoharu Hamada, Nozomu Kawashima, Atsushi Narita, Nobuhiro Nishio, Seiji Kojima, Tomohiko Nakata, Hiroyuki Kidokoro, Jun Natxume, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S30 - S30 2019.12

A CaseWith Dyskeratosis Congenita Achieved Transfusion Independence after Eltrombopag Treatment

Wakamatsu, M; Muramatsu, H; Imaya, M; Yamamori, A; Yoshida, T; Miwata, S; Kitazawa, H; Narita, K; Ichikawa, D; Hamada, M; Taniguchi, R; Kawasima, N; Nishikawa, E; Narita, A; Okuno, Y; Nishio, N; Kojima, S; Takahashi, Y

PEDIATRIC BLOOD & CANCER Vol. 66 page： S46 - S46 2019.12

Clinical and Laboratory Characteristics of Atypical Chronic Myeloid Leukemia and Chronic Myelomonocytic Leukemia in Japanese Children

Hama, A; Ito, M; Hasegawa, D; Nozawa, K; Muramatsu, H; Takahashi, Y; Watanabe, K; Ohara, A; Manabe, A; Kojima, S

PEDIATRIC BLOOD & CANCER Vol. 66 page： S21 - S22 2019.12

An Infant With Hereditary Folate Malabsorption Requiring Differentiation from Acute Megakaryoblastic Leukemia

Eri Nishikawa, Rieko Taniguchi, Tarou Yoshida, Masayuki Imaya, Manabu Wakamatsu, Syunsuke Miwata, Koutarou Narita, Ayako Yamamori, Hironobu Kitazawa, Daisuke Ichikawa, Motoharu Hamada, Nozomu Kawashima, Atsushi Narita, Yusuke Okuno, Hideki Muramatsu, Nobuhiro Nishio, Seiji Kojima, Shimaa Said, Yusuke Tozawa, Masafumi Yamada, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S73 - S73 2019.12

Identification of <i>FANCI</i> Mutation in Fanconi Anemia in Infancy

Urata, T; Imamura, T; Osone, S; Muramatsu, H; Takahashi, Y; Hosoi, H

PEDIATRIC BLOOD & CANCER Vol. 66 page： S44 - S44 2019.12

Integrating FANCD2 Functional Analysis With High-Throughput Sequencing for Diagnosing Fanconi Anemia

Nozomu Kawashima, Yusuke Okuno, Hideki Muramatsu, Rieko Taniguchi, Taro Yoshida, Masayuki Imaya, Ayako Yamamori, Manabu Wakamatsu, Shunsuke Miwata, Kotaro Narita, Motoharu Hamada, Daisuke Ichikawa, Nobuhiro Kitazawa, Eri Nishikawa, Atsushi Narita, Nobuhiro Nishio, Seiji Kojima, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S44 - S45 2019.12

Induction of Partial Response With Ceritinib for a Child With Chemotherapy-Refractory ALK-rearranged Neuroblastoma

Kotaro Narita, Taro Yoshida, Ayako Yamamori, Manabu Wakamatsu, Masayuki Imaya, Shunsuke Miwata, Hironobu Kitazawa, Rieko Taniguchi, Daisuke Ichikawa, Motoharu Hamada, Eri Nishikawa, Nobuhiro Nishio, Yusuke Okuno, Nozomu Kawashima, Atsushi Narita, Hideki Muramatsu, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S104 - S104 2019.12

Conditioning Regimen for Allogeneic Bone Marrow Transplantation in Children With Acquired Bone Marrow Failure: Fludarabine/Melphalan vs. Fludarabine/Cyclophosphamide

Yoshida, N; Takahashi, Y; Yabe, H; Kobayashi, R; Watanabe, K; Kudo, K; Yabe, M; Miyamura, T; Koh, K; Kawaguchi, H; Goto, H; Fujita, N; Hara, J; Okamoto, Y; Kato, K; Inoue, M; Suzuki, R; Atsuta, Y; Kojima, S

PEDIATRIC BLOOD & CANCER Vol. 66 page： S95 - S95 2019.12

Genetic Diagnosis Based on a Comprehensive Fusion Gene Analysis of Pediatric Malignant Solid Tumors

Daisuke Ichikawa, Hideki Muramatsu, Yusuke Okuno, Motoharu Hamada, Rieko Taniguchi, Eri Nishikawa, Nozomu Kawashima, Atsushi Narita, Nobuhiro Nishio, Yoshie Shimoyama, Masato Nakaguro, Shigeo Nakamura, Seiji Kojima, Atsuko Nakazawa, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S61 - S61 2019.12

Evaluation of the Outcome of KIR-Ligand Mismatched Cord Blood Transplantation for High Risk Metastatic Neuroblastoma Using New SIOPEN Risk Stratification

Nobuhiro Nishio, Daisuke Ichikawa, Manabu Wakamatsu, Kotaro Narita, Shunsuke Miwata, Hironobu Kitazawa, Rieko Taniguchi, Motoharu Hamada, Eri Nishikawa, Nozomu Kawashima, Yusuke Okuno, Atsushi Narita, Hideki Muramatsu, Seiji Kojima, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S106 - S106 2019.12

Correlation Between Plasma Rabbit Anti-Thymocyte Globulin Level and Response to Immunosuppressive Therapy in Patients With Severe Aplastic Anemia

Atsushi Narita, Hideki Muramatsu, Motoharu Hamada, Daisuke Ichikawa, Eri Nishikawa, Nozomu Kawashima, Yusuke Okuno, Nobuhiro Nishio, Hirohito Yamazaki, Shinji Nakao, Seiji Kojima, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S45 - S45 2019.12

Two Cases Effectively Treated with Oral Budesonide Administration for Steroid-resistant Intestinal Acute Graft Versus Host Disease

Ayako Yamamori, Eri Nishikawa, Atsushi Narita, Masayuki Imaya, Manabu Wakamatsu, Taro Yoshida, Shunsuke Miwata, Hironobu Kitazawa, Kotaro Narita, Rieko Taniguchi, Daisuke Ichikawa, Motoharu Hamada, Nozomu Kawashima, Yusuke Okuno, Nobuhiro Nishio, Hideki Muramatsu, Seiji Kojima, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S37 - S38 2019.12

Whole Exome Sequencing Contributes to Genetic Diagnosis of IBMFS Patients

Hideki Muramatsu, Motoharu Hamada, Yusuke Okuno, Manabu Wakamatsu, Rieko Taniguchi, Koutarou Narita, Nozomu Kawashima, Hironobu Kitazawa, Daisuke Ichikawa, Eri Nishikawa, Nazomu Kawashima, Atsushi Narita, Nobuhiro Nishio, Seiji Kojima, Tomoo Ogi, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S63 - S64 2019.12

Prediction of postnatal clinical course in primary congenital dilated cardiomyopathy. Reviewed International journal

Hidenori Yamamoto, Yoshie Fukasawa, Naoki Ohashi, Takehiko Yokoyama, Kazutaka Suzuki, Takaya Ota, Kazushi Yasuda, Kentaro Omoya, Yoshiyuki Takahashi, Taichi Kato

Pediatrics international : official journal of the Japan Pediatric Society Vol. 61 ( 12 ) page： 1196 - 1201 2019.12

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The aim of this study was to investigate the prediction of postnatal prognosis using fetal and perinatal data in patients with primary congenital dilated cardiomyopathy (PCDCM), and to estimate the incidence of this disease. METHODS: We examined correlations between fetal or perinatal data and postnatal clinical course in a multicenter retrospective study of eight patients with PCDCM. Incidence was calculated in a population-based study. RESULTS: All patients developed heart failure at a median of 8 days (range, 0-43 days), and six patients died or required extracorporeal artificial heart therapy at a median of 67 days (range, 0-92 days). The cardiothoracic area ratio from fetal echocardiography, the Apgar score, and the standard deviation of birth weight correlated significantly with the date at onset of heart failure. However, no data correlated with survival. Cumulative incidence of PCDCM was calculated as 1.21 per 100 000 total births (95% confidence interval, 0.37 to 2.06). CONCLUSIONS: Primary congenital dilated cardiomyopathy has a poor prognosis, but cardiothoracic area ratio from fetal echocardiography, body weight at birth, and Apgar score correlate with the timing of the onset of heart failure, and these indicators might therefore be useful for peri- and postnatal management.

DOI： 10.1111/ped.14029

Web of Science

PubMed

Successfully Treated Three Children With Pericardial Effusion After Hematopoietic Stem Cell Transplantation

Hironobu Kitazawa, Atsushi Narita, Taro Yoshida, Masayuki Imaya, Ayako Yamamori, Manabu Wakamatsu, Shunsuke Miwata, Kotaro Narita, Rieko Taniguchi, Motoharu Hamada, Daisuke Ichikawa, Eri Nishikawa, Nozomu Kawashima, Yusuke Okuno, Nobuhiro Nishio, Hideki Muramatsu, Seiji Kojima, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S97 - S97 2019.12

Successful Treatment of Central Nervous System Relapses of Neuroblastoma Stage 4 After a KIR-ligand Mismatched Allogeneic Cord Blood Transplantation

Masayuki Imaya, Atsushi Narita, Taro Yoshida, Ayako Yamamori, Manabu Wakamatsu, Syunsuke Miwata, Kotaro Narita, Hironobu Kitazawa, Rieko Taniguchi, Daisuke Ichikawa, Motoharu Hamada, Eri Nishikawa, Nozomu Kawashima, Hideki Muramatsu, Nobuhiro Nishio, Seiji Kojima, Yoshiyuki Takahashi

PEDIATRIC BLOOD & CANCER Vol. 66 page： S102 - S102 2019.12

Comprehensive Mutational Analysis of Juvenile Myelomonocytic Leukemia Using Whole-Genome Sequencing Open Access

Yusuke Okuno, Hideki Muramatsu, Norihiro Murakami, Nozomu Kawashima, Manabu Wakamatsu, Hironobu Kitazawa, Tomoo Ogi, Yoshiyuki Takahashi

BLOOD Vol. 134 2019.11

Genome-Wide Methylation Analysis Using the Digital Restriction Enzyme Analysis of Methylation for Stratification of Patients with Juvenile Myelomonocytic Leukemia Open Access

Hironobu Kitazawa, Hideki Muramatsu, Norihiro Murakami, Yusuke Okuno, Manabu Wakamatsu, Taro Yoshida, Masayuki Imaya, Ayako Yamamori, Shunsuke Miwata, Kotaro Narita, Motoharu Hamada, Daisuke Ichikawa, Rieko Taniguchi, Nozomu Kawashima, Eri Nishikawa, Atsushi Narita, Nobuhiro Nishio, Seiji Kojima, Yoshiyuki Takahashi

BLOOD Vol. 134 2019.11

DNA Methylation As a Biomarker of Outcome in JMML: An International Effort Towards Clinical Implementation

Meyer, J; Schönung, M; Flotho, C; Olshen, AB; Hartmann, M; Plass, C; Okuno, Y; Takahashi, Y; Murakami, N; Wakamatsu, M; Loh, ML; Niemeyer, CM; Muramatsu, H; Lipka, DB; Stieglitz, E

BLOOD Vol. 134 2019.11

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Papers - TAKAHASHI, Yoshiyuki