Faculty Profiles - TAKAHASHI, Yoshiyuki

Papers - TAKAHASHI, Yoshiyuki

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Dyskeratosis Congenita Complicated by Pulmonary Fibrosis and Myelodysplastic Syndrome with a Germline Mutation of the DKC1 Gene and a Somatic Mutation of the U2AF1 Gene in Leukocytes. Open Access

Watanabe H, Takahashi Y, Namiki T, Nakagawa R, Inui T, Ishikawa H, Wakamatsu M, Muramatsu H, Sakamoto T

Internal medicine (Tokyo, Japan) 2025.4

Early discontinuation of steroid treatment in children with abdominal pain due to IgA vasculitis.

Kambara S, Nishio N, Sugiyama Y, Nishio Y, Takamoto Y, Kitai F, Takahashi Y, Hayashi N, Haruta K, Kondo M, Oike N, Miwa T, Watanabe N, Omori M, Kinoshita F, Furukawa T, Kawada JI, Kidokoro H, Sato Y, Takahashi Y, Nagoya Collaborative Clinical Research Team

European journal of pediatrics Vol. 184 ( 5 ) page： 279 2025.4

Adjunctive effects of eltrombopag on immunosuppressive therapy for childhood aplastic anemia.

Eguchi K, Ishimura M, Ohga S, Endo S, Saito S, Kamimura S, Keino D, Kato S, Azuma Y, Watanabe A, Inoue A, Higa T, Ozono S, Fujita N, Watanabe K, Takahashi Y, Japan Childhood Aplastic Anemia Study Group

International journal of hematology Vol. 121 ( 4 ) page： 533 - 542 2025.4

Diffuse but Non-homogeneous Brain Atrophy: Identification of Specific Brain Regions and Their Correlation with Clinical Severity in Rett Syndrome

Hajime Narita, Jun Natsume, Takeshi Suzuki, Tadashi Shiohama, Masahiro Kawaguchi, Masaki Okazaki, Atsushi Hashizume, Shinji Naganawa, Yuji Ito, Hiroyuki Yamamoto, Tomohiko Nakata, Hiroyuki Kidokoro, Yoshiyuki Takahashi, Satoru Takahashi, Keita Tsujimura

Brain and Development Vol. 47 ( 3 ) page： 104348 - 104348 2025.3

Comparable impact of lymph node metastases in T2 gallbladder cancer on postoperative prognosis irrespective of the extent of the metastases: A retrospective analysis. Open Access

Kishi Y, Sugiura T, Mizuno T, Ito H, Takahashi Y, Noji T, Abe Y, Otsuka S, Kawakatsu S, Kato A, Tanaka M, Ebata T, Hirano S

Journal of hepato-biliary-pancreatic sciences 2025.3

Direct Extraction and Evaluation of Intraluminal Vesicles Inside a Single Cell.

Ida H, Yoshida T, Kumatani A, Hanayama R, Takahashi Y

Nano letters Vol. 25 ( 11 ) page： 4322 - 4329 2025.3

Characteristics of neonatal-onset and presumed neonatal arterial ischemic stroke.

Ueda K, Kataoka E, Natsume J, Hori I, Tsuji T, Miyake M, Suzuki M, Kobayashi S, Kurahashi H, Sato Y, Okumura A, Yoshikawa T, Saitoh S, Takahashi Y

Brain & development Vol. 47 ( 3 ) page： 104343 2025.3

Retrospective nationwide survey of pediatric RDD in Japan: a high prevalence of mutations in the kinase pathway genes.

Asano T, Morimoto A, Nakazawa A, Ueda T, Ogawa C, Sakata N, Sugimoto K, On J, Takahashi Y, Otsuki N, Taneyama Y, Hyakuna N, Ishihara T, Matsumine A, Shioda Y, Sakamoto K, Nakazawa Y, Yasumi T, Doi T, Koga Y, Histiocytosis Study Group of the Japanese Society of Pediatric Hematology/Oncology

International journal of hematology 2025.3

Predicting Postoperative Neurological Outcomes in Metastatic Spinal Tumor Surgery Using Machine Learning.

Maki S, Shiratani Y, Orita S, Suzuki A, Tamai K, Shimizu T, Kakutani K, Kanda Y, Tominaga H, Kawamura I, Ishihara M, Paku M, Takahashi Y, Funayama T, Miura K, Shirasawa E, Inoue H, Kimura A, Iimura T, Moridaira H, Nakajima H, Watanabe S, Akeda K, Takegami N, Nakanishi K, Sawada H, Matsumoto K, Funaba M, Suzuki H, Funao H, Oshigiri T, Hirai T, Otsuki B, Kobayakawa K, Uotani K, Manabe H, Tanishima S, Hashimoto K, Iwai C, Yamabe D, Hiyama A, Seki S, Kato K, Miyazaki M, Watanabe K, Nakamae T, Kaito T, Nakashima H, Nagoshi N, Inoue G, Imagama S, Watanabe K, Kato S, Ohtori S, Furuya T, JASA Study Group

Spine 2025.3

Plasma Proteomic Profiles of Pediatric Patients With Human Herpesvirus 6B Encephalitis Following Umbilical Cord Blood Transplantation

Kazunori Haruta, Yuto Fukuda, Hisateru Yamaguchi, Yoshiki Kawamura, Takako Suzuki, Yuka Torii, Atsushi Narita, Hideki Muramatsu, Hiroyuki Kidokoro, Jun Natsume, Yoshiyuki Takahashi, Tetsushi Yoshikawa, Jun‐ichi Kawada

Journal of Medical Virology Vol. 97 ( 3 ) page： e70311 2025.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

ABSTRACT

Human herpesvirus 6B (HHV‐6B) encephalitis is a rare but severe complication of hematopoietic cell transplantation. This study investigated the pathogenesis of HHV‐6B encephalitis by comparing plasma proteomic profiles of four pediatric patients with HHV‐6B encephalitis to three with asymptomatic HHV‐6B reactivation following umbilical cord blood transplantation (UCBT). Plasma proteomic profiling was conducted using liquid chromatography‐mass spectrometry. Overall, 260 proteins were identified and quantified in plasma samples. At the onset of HHV‐6B encephalitis and asymptomatic reactivation, 20 and 24 proteins, respectively, were significantly upregulated compared to their respective pre‐onset levels. Of these, 11 proteins were uniquely upregulated in HHV‐6B encephalitis. S100‐A9 and S100‐A8 were the most and second‐most upregulated proteins in HHV‐6B encephalitis, respectively. Elevated plasma S100A8/A9 heterodimer levels were confirmed via enzyme‐linked immunosorbent assay in three of the four patients with HHV‐6B encephalitis. Pathway analysis identified neutrophil degranulation as the most enriched category among upregulated proteins in HHV‐6B encephalitis. Additionally, proteins related to the protein‐lipid complex remodeling pathway were more prominently upregulated in HHV‐6B encephalitis than in asymptomatic reactivation. Proteomic analysis revealed distinct plasma protein profiles between HHV‐6B encephalitis and asymptomatic HHV‐6B reactivation in pediatric UCBT recipients. The inflammatory response mediated by S100A8/A9 proteins may play a critical role in the pathogenesis of HHV‐6B encephalitis. These findings indicate that proteomic analysis may provide novel insights into the host response to HHV‐6B reactivation and the subsequent development of HHV‐6B encephalitis.

DOI： 10.1002/jmv.70311

PubMed

Increased response to granulocyte-macrophage colony-stimulating factor in peripheral blood cells and transient manifestations mimicking juvenile myelomonocytic leukemia in a male patient with NEMO deficiency caused by a deep intronic pathogenic variant of IKBKG. Open Access

Ueki M, Hirabayashi S, Honda Y, Takezaki S, Ohata H, Abdrabou SSMA, Sawai S, Terashita Y, Cho Y, Muramatsu H, Izawa K, Yasumi T, Takahashi Y, Yamada M, Manabe A

Immunological medicine Vol. 48 ( 1 ) page： 94 - 101 2025.3

Successful Treatment with Sirolimus of a Patient with a Novel CARD11 Germline Mutation in B-Cell Expansion with Nuclear Factor Kappa B and T-Cell Anergy: Case Report and Literature Review. Open Access

Nishinosono T, Muramatsu H, Wakamatsu M, Yamashita D, Fukasawa T, Shirakawa Y, Sajiki D, Maemura R, Tsumura Y, Yamamori A, Narita K, Kataoka S, Narita A, Nishio N, Miyajima Y, Takahashi Y

Journal of clinical immunology Vol. 45 ( 1 ) page： 78 2025.2

Application of simple preparation for pediatric magnetic resonance imaging: a multicenter study in Japan.

Sawada N, Kawada JI, Kito S, Takeo T, Narita H, Fukushima M, Masuda Y, Mitsumatsu T, Kawano Y, Sakaguchi Y, Nishio N, Kidokoro H, Sato Y, Takahashi Y, Nagoya Collaborative Clinical Research Team

Pediatric radiology 2025.2

Nanoscale visualization of the anti-tumor effect of a plasma-activated Ringer's lactate solution. Open Access

Usuda J, Yagyu K, Tanaka H, Hori M, Ishikawa K, Takahashi Y

Faraday discussions Vol. 257 ( 0 ) page： 212 - 223 2025.2

Motor and functional characteristics in school-age survivors of congenital diaphragmatic hernia: a cross-sectional observational study.

Mitsumatsu T, Ito Y, Muramatsu Y, Sato Y, Ito T, Narahara S, Miura R, Yamamoto H, Ito M, Shiraki A, Nakata T, Kotani T, Natsume J, Hayakawa M, Takahashi Y, Kidokoro H

Archives of disease in childhood. Fetal and neonatal edition 2025.2

Surgical strategy for metastatic spinal tumors based on Spine Instability Neoplastic Score and patient-reported outcomes: JASA multicenter prospective study. Open Access

Nakajima H, Watanabe S, Honjoh K, Kubota A, Shiratani Y, Suzuki A, Terai H, Shimizu T, Kakutani K, Kanda Y, Tominaga H, Kawamura I, Ishihara M, Paku M, Takahashi Y, Funayama T, Miura K, Shirasawa E, Inoue H, Kimura A, Iimura T, Moridaira H, Akeda K, Takegami N, Nakanishi K, Sawada H, Matsumoto K, Funaba M, Suzuki H, Funao H, Oshigiri T, Hirai T, Otsuki B, Kobayakawa K, Uotani K, Manabe H, Tanishima S, Hashimoto K, Iwai C, Yamabe D, Hiyama A, Seki S, Goto Y, Miyazaki M, Watanabe K, Nakamae T, Kaito T, Nakashima H, Nagoshi N, Kato S, Imagama S, Watanabe K, Inoue G, Furuya T

Journal of neurosurgery. Spine Vol. 42 ( 2 ) page： 203 - 214 2025.2

Real-world Outcomes of Commercial Tisagenlecleucel for Children, Adolescents, and Young Adults With Acute Lymphoblastic Leukemia in Japan. Open Access

Kato I, Tomizawa D, Kato M, Hirabayashi S, Manabe A, Irie M, Sasahara Y, Arakawa Y, Koh K, Sakaguchi H, Sugiyama M, Ogawa C, Kamiya T, Saito S, Nakazawa Y, Nishio N, Takahashi Y, Iwai N, Adachi S, Takita J, Miyamura T, Yokoyama S, Oba U, Ueda T, Koga Y, Hiramatsu H

Transplantation and cellular therapy Vol. 31 ( 2 ) page： 86 - 96 2025.2

Mechanical signaling through membrane tension induces somal translocation during neuronal migration. Open Access

Minegishi T, Hasebe H, Aoyama T, Naruse K, Takahashi Y, Inagaki N

The EMBO journal Vol. 44 ( 3 ) page： 767 - 780 2025.2

Cord Blood Transplantation Using Myeloablative Conditioning for Pediatric Advanced Myelodysplastic Syndrome in AMeD Syndrome With a Novel ADH5 Variant.

Morishita Y, Hamada M, Uemura S, Kikuchi H, Hisakawa H, Fujikawa T, Tamura A, Okuno Y, Wakamatsu M, Muramatsu H, Takahashi Y, Hasegawa D, Kosaka Y

Pediatric blood & cancer Vol. 72 ( 2 ) page： e31465 2025.2

Identification of a Novel Stomatal Opening Chemical, PP242, That Inhibits Early Abscisic Acid Signal Transduction in Guard Cells.

Oh A, Kimura R, Inoue S, Sato T, Hayashi Y, Sato A, Takahashi Y, Kinoshita T

Plant & cell physiology 2025.1

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Papers - TAKAHASHI, Yoshiyuki