Faculty Profiles - TAKAHASHI, Yoshiyuki

Papers - TAKAHASHI, Yoshiyuki

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Impact of center volume on acute graft versus host disease in allogeneic stem cell transplant recipients.

Shimomura Y, Terakura S, Matsuo K, Ito Y, Ichinohe T, Hashii Y, Goto H, Kato K, Kawamura K, Onizuka M, Ishimaru F, Takahashi Y, Yanagisawa A, Ohbiki M, Tabuchi K, Atsuta Y, Fukuda T, Kanda J, Murata M

International journal of hematology Vol. 122 ( 4 ) page： 559 - 571 2025.10

Whole-genome sequencing reveals genetic backgrounds in Japanese patients with hemophagocytic lymphohistiocytosis treated with the HLH-2004 protocol.

Yanagisawa R, Wakamatsu M, Tomomasa D, Sakamoto K, Ono R, Doi T, Kudo K, Fujino H, Kudo K, Morimoto A, Shioda Y, Yasumi T, Makishima H, Muramatsu H, Takahashi Y, Kanegane H, Nakazawa Y, HLH/LCH Committee Members of the Japan Children’s Cancer Group

International journal of hematology Vol. 122 ( 4 ) page： 583 - 589 2025.10

Cystathionine as a Potential Urinary Marker for Diagnosing and Assessing Pretreatment Risk in Neuroblastoma.

Amano H, Hayashi Y, Harada K, Narita A, Fumino S, Yamada Y, Karakawa S, Sakairi M, Shirota C, Tainaka T, Yokota K, Makita S, Kato D, Ishii H, Deie K, Mori M, Mitani Y, Tomioka Y, Taguri M, Koh K, Tajiri T, Kato M, Matsumoto K, Takahashi Y, Iehara T, Hinoki A, Uchida H

Cancer science 2025.8

Prevalence and outcome of VEXAS syndrome in unrelated hematopoietic cell transplantation for bone marrow failure.

Zaimoku Y, Imi T, Hatada T, Mizumaki H, Mura H, Yoshino H, Kano Y, Kobayashi M, Morishita E, Fushida N, Matsushita T, Mizuguchi K, Ikeda H, Nannya Y, Ogawa S, Hosomichi K, Doki N, Katayama Y, Koike T, Matsuoka KI, Nishida T, Takahashi Y, Kataoka K, Nakazawa H, Ueda Y, Fukuda T, Ichinohe T, Ishimaru F, Onizuka M, Atsuta Y, Miyamoto T, Japanese Society of Transplantation and Cellular Therapy

Clinical and experimental medicine Vol. 25 ( 1 ) page： 300 2025.8

Motor and functional characteristics in school-age survivors of congenital diaphragmatic hernia: a cross-sectional observational study.

Mitsumatsu T, Ito Y, Muramatsu Y, Sato Y, Ito T, Narahara S, Miura R, Yamamoto H, Ito M, Shiraki A, Nakata T, Kotani T, Natsume J, Hayakawa M, Takahashi Y, Kidokoro H

Archives of disease in childhood. Fetal and neonatal edition Vol. 110 ( 5 ) page： 492 - 497 2025.8

Clinical outcomes of Japanese patients treated with out-of-specification tisagenlecleucel in a phase 3b trial.

Kato K, Kato J, Goto H, Kobayashi T, Takahashi Y, Sakaida E, Hiramatsu H, Yamamoto M, Yoshihara S, Ando J, Koh K, Fukushima K, Iwamoto F, Tiwari R, Fujii N

Cytotherapy Vol. 27 ( 8 ) page： 938 - 943 2025.8

Post-transplant maintenance with blinatumomab for children, adolescents, and young adults with relapsed and refractory B-cell acute lymphoblastic leukemia: results of phase I in SCT-ALL-BLIN21.

Sakaguchi H, Sakaguchi K, Kato I, Noma H, Hiramatsu H, Ishida H, Yabe H, Goto H, Kawahara Y, Yamashita YI, Sanada M, Deguchi T, Takahashi Y, Saito AM, Takagi M, Okuno K, Taga T, Horibe K, Okamoto Y, Koh K, Manabe A, Umeda K

Haematologica 2025.7

Retrospective nationwide survey of pediatric RDD in Japan: a high prevalence of mutations in the kinase pathway genes.

Asano T, Morimoto A, Nakazawa A, Ueda T, Ogawa C, Sakata N, Sugimoto K, On J, Takahashi Y, Otsuki N, Taneyama Y, Hyakuna N, Ishihara T, Matsumine A, Shioda Y, Sakamoto K, Nakazawa Y, Yasumi T, Doi T, Koga Y, Histiocytosis Study Group of the Japanese Society of Pediatric Hematology/Oncology

International journal of hematology Vol. 122 ( 1 ) page： 128 - 137 2025.7

Diffuse but Non-homogeneous Brain Atrophy: Identification of Specific Brain Regions and Their Correlation with Clinical Severity in Rett Syndrome Open Access

Hajime Narita, Jun Natsume, Takeshi Suzuki, Tadashi Shiohama, Masahiro Kawaguchi, Masaki Okazaki, Atsushi Hashizume, Shinji Naganawa, Yuji Ito, Hiroyuki Yamamoto, Tomohiko Nakata, Hiroyuki Kidokoro, Yoshiyuki Takahashi, Satoru Takahashi, Keita Tsujimura

Brain and Development Vol. 47 ( 3 ) page： 104348 - 104348 2025.6

Comparable impact of lymph node metastases in T2 gallbladder cancer on postoperative prognosis irrespective of the extent of the metastases: A retrospective analysis.

Kishi Y, Sugiura T, Mizuno T, Ito H, Takahashi Y, Noji T, Abe Y, Otsuka S, Kawakatsu S, Kato A, Tanaka M, Ebata T, Hirano S

Journal of hepato-biliary-pancreatic sciences Vol. 32 ( 6 ) page： 443 - 451 2025.6

Characteristics of neonatal-onset and presumed neonatal arterial ischemic stroke.

Ueda K, Kataoka E, Natsume J, Hori I, Tsuji T, Miyake M, Suzuki M, Kobayashi S, Kurahashi H, Sato Y, Okumura A, Yoshikawa T, Saitoh S, Takahashi Y

Brain & development Vol. 47 ( 3 ) page： 104343 2025.6

Impact of 10% vs. 5% immunoglobulin products on treatment outcomes in Kawasaki disease: a multicenter retrospective study. Open Access

Sajiki D, Nishio N, Kato T, Hirao T, Suzuki K, Go K, Kinoshita F, Kidokoro H, Kawada JI, Sato Y, Takahashi Y

Scientific reports Vol. 15 ( 1 ) page： 18502 2025.5

Impact of surgical treatment on patient reported outcome in patients with spinal metastases from prostate cancer.

Hirota R, Oshigiri T, Iesato N, Emori M, Teramoto A, Shiratani Y, Suzuki A, Terai H, Shimizu T, Kakutani K, Kanda Y, Tominaga H, Kawamura I, Ishihara M, Paku M, Takahashi Y, Funayama T, Miura K, Shirasawa E, Inoue H, Kimura A, Iimura T, Moridaira H, Nakajima H, Watanabe S, Akeda K, Takegami N, Nakanishi K, Sawada H, Matsumoto K, Funaba M, Suzuki H, Funao H, Hirai T, Otsuki B, Kobayakawa K, Uotani K, Manabe H, Tanishima S, Hashimoto K, Iwai C, Yamabe D, Hiyama A, Seki S, Goto Y, Miyazaki M, Watanabe K, Nakamae T, Kaito T, Nakashima H, Nagoshi N, Kato S, Imagama S, Watanabe K, Inoue G, Furuya T

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association Vol. 30 ( 3 ) page： 423 - 432 2025.5

Effects of Palliative Surgical Treatment for Spinal Metastases on the Patient's Quality of Life With a Focus on the Segment of the Metastasis: A Prospective Multicenter Study.

Segi N, Nakashima H, Ito S, Ouchida J, Shiratani Y, Shimizu T, Suzuki A, Terai H, Kakutani K, Kanda Y, Tominaga H, Kawamura I, Ishihara M, Paku M, Takahashi Y, Funaba M, Funayama T, Nakajima H, Akeda K, Hirai T, Inoue H, Nakanishi K, Funao H, Oshigiri T, Otsuki B, Kobayakawa K, Tanishima S, Hashimoto K, Iimura T, Sawada H, Uotani K, Manabe H, Iwai C, Yamabe D, Hiyama A, Seki S, Goto Y, Miyazaki M, Watanabe K, Nakamae T, Kaito T, Nagoshi N, Kato S, Watanabe K, Imagama S, Inoue G, Furuya T

Global spine journal Vol. 15 ( 4 ) page： 2286 - 2299 2025.5

Application of simple preparation for pediatric magnetic resonance imaging: a multicenter study in Japan.

Sawada N, Kawada JI, Kito S, Takeo T, Narita H, Fukushima M, Masuda Y, Mitsumatsu T, Kawano Y, Sakaguchi Y, Nishio N, Kidokoro H, Sato Y, Takahashi Y, Nagoya Collaborative Clinical Research Team

Pediatric radiology Vol. 55 ( 5 ) page： 976 - 982 2025.5

Reply to Cukierman BS.

Sawada N, Kawada JI, Sato Y, Takahashi Y

Pediatric radiology Vol. 55 ( 5 ) page： 985 - 986 2025.5

Dyskeratosis Congenita Complicated by Pulmonary Fibrosis and Myelodysplastic Syndrome with a Germline Mutation of the DKC1 Gene and a Somatic Mutation of the U2AF1 Gene in Leukocytes.

Watanabe H, Takahashi Y, Namiki T, Nakagawa R, Inui T, Ishikawa H, Wakamatsu M, Muramatsu H, Sakamoto T

Internal medicine (Tokyo, Japan) 2025.4

Early discontinuation of steroid treatment in children with abdominal pain due to IgA vasculitis.

Kambara S, Nishio N, Sugiyama Y, Nishio Y, Takamoto Y, Kitai F, Takahashi Y, Hayashi N, Haruta K, Kondo M, Oike N, Miwa T, Watanabe N, Omori M, Kinoshita F, Furukawa T, Kawada JI, Kidokoro H, Sato Y, Takahashi Y, Nagoya Collaborative Clinical Research Team

European journal of pediatrics Vol. 184 ( 5 ) page： 279 2025.4

Adjunctive effects of eltrombopag on immunosuppressive therapy for childhood aplastic anemia.

Eguchi K, Ishimura M, Ohga S, Endo S, Saito S, Kamimura S, Keino D, Kato S, Azuma Y, Watanabe A, Inoue A, Higa T, Ozono S, Fujita N, Watanabe K, Takahashi Y, Japan Childhood Aplastic Anemia Study Group

International journal of hematology Vol. 121 ( 4 ) page： 533 - 542 2025.4

Plasma Proteomic Profiles of Pediatric Patients With Human Herpesvirus 6B Encephalitis Following Umbilical Cord Blood Transplantation Reviewed Open Access

Kazunori Haruta, Yuto Fukuda, Hisateru Yamaguchi, Yoshiki Kawamura, Takako Suzuki, Yuka Torii, Atsushi Narita, Hideki Muramatsu, Hiroyuki Kidokoro, Jun Natsume, Yoshiyuki Takahashi, Tetsushi Yoshikawa, Jun‐ichi Kawada

Journal of Medical Virology Vol. 97 ( 3 ) page： e70311 2025.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

ABSTRACT

Human herpesvirus 6B (HHV‐6B) encephalitis is a rare but severe complication of hematopoietic cell transplantation. This study investigated the pathogenesis of HHV‐6B encephalitis by comparing plasma proteomic profiles of four pediatric patients with HHV‐6B encephalitis to three with asymptomatic HHV‐6B reactivation following umbilical cord blood transplantation (UCBT). Plasma proteomic profiling was conducted using liquid chromatography‐mass spectrometry. Overall, 260 proteins were identified and quantified in plasma samples. At the onset of HHV‐6B encephalitis and asymptomatic reactivation, 20 and 24 proteins, respectively, were significantly upregulated compared to their respective pre‐onset levels. Of these, 11 proteins were uniquely upregulated in HHV‐6B encephalitis. S100‐A9 and S100‐A8 were the most and second‐most upregulated proteins in HHV‐6B encephalitis, respectively. Elevated plasma S100A8/A9 heterodimer levels were confirmed via enzyme‐linked immunosorbent assay in three of the four patients with HHV‐6B encephalitis. Pathway analysis identified neutrophil degranulation as the most enriched category among upregulated proteins in HHV‐6B encephalitis. Additionally, proteins related to the protein‐lipid complex remodeling pathway were more prominently upregulated in HHV‐6B encephalitis than in asymptomatic reactivation. Proteomic analysis revealed distinct plasma protein profiles between HHV‐6B encephalitis and asymptomatic HHV‐6B reactivation in pediatric UCBT recipients. The inflammatory response mediated by S100A8/A9 proteins may play a critical role in the pathogenesis of HHV‐6B encephalitis. These findings indicate that proteomic analysis may provide novel insights into the host response to HHV‐6B reactivation and the subsequent development of HHV‐6B encephalitis.

DOI： 10.1002/jmv.70311

PubMed

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Papers - TAKAHASHI, Yoshiyuki