研究者詳細 - 八谷　寛

論文 - 八谷　寛

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特定保健指導レベルと2型糖尿病発症の関連・その臨床疫学的指標愛知職域コホート

金子佳世, 八谷寛, 李媛英, 上村真由, 江啓発, 平川仁尚, 内藤久雄, 太田充彦, 玉腰浩司, 青山温子

産業衛生学雑誌 61 巻 ( 臨増 ) 頁： 321 - 321 2019年5月

トリクロロエチレンによるCYP2E1抗体上昇とhypersensitivity syndromeとの関係

那須民江, 王海蘭, 袁媛, 内藤久雄, 伊藤由起, 八谷寛, 上島通浩

産業衛生学雑誌 61 巻 ( 臨増 ) 頁： 332 - 332 2019年5月

Recent Status and Methodological Quality of Return-to-Work Rates of Cancer Patients Reported in Japan: A Systematic Review 査読有り国際誌

Ota, A; Fujisawa, A; Kawada, K; Yatsuya, H

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 16 巻 ( 8 ) 2019年4月

Validation of the Japanese Version of the Yale Food Addiction Scale 2.0 (J-YFAS 2.0) 査読有り国際共著

Khine, MT; Ota, A; Gearhardt, AN; Fujisawa, A; Morita, M; Minagawa, A; Li, YY; Naito, H; Yatsuya, H

NUTRIENTS 11 巻 ( 3 ) 頁： 687 - 687 2019年3月

Multicenter feasibility study of bowel preparation with castor oil for colon capsule endoscopy 査読有り国際誌

Ohmiya, N; Hotta, N; Mitsufuji, S; Nakamura, M; Omori, T; Maeda, K; Okuda, K; Yatsuya, H; Tajiri, H

DIGESTIVE ENDOSCOPY 31 巻 ( 2 ) 頁： 164 - 172 2019年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Digestive Endoscopy

Background and Aim: Extensive use of laxatives and incomplete excretion rates are problematic for colon capsule endoscopy (CCE). The aim of the present study was to determine the effectiveness of castor oil as a booster. Methods: At four Japanese hospitals, 319 examinees undergoing CCE were enrolled retrospectively. Before and after the introduction of castor oil, other preparation reagents were unchanged. Results: Of 319 examinees who underwent CCE, 152 and 167 examinees took regimens with castor oil (between November 2013 and June 2016) and without castor oil (between October 2015 and September 2017), respectively. Capsule excretion rates within its battery life in the groups with and without castor oil were 97% and 81%, respectively (P < 0.0001). Multivariate analysis showed that ages younger than 65 years (adjusted odds ratio [OR], 3.00; P = 0.0048), male gender (adjusted OR, 3.20; P = 0.0051), and use of castor oil (adjusted OR, 6.29; P = 0.0003) were predictors of capsule excretion within its battery life. Small bowel transit time was shorter and total volume of lavage and fluid intake was lower with castor oil than without (P = 0.0154 and 0.0013, respectively). Overall adequate cleansing level ratios with and without castor oil were 74% and 83%, respectively (P = 0.0713). Per-examinee sensitivity for polyps ≥6 mm with and without castor oil was 83% and 85%, respectively, with specificities of 80% and 78%, respectively. Conclusion: Bowel preparation with castor oil was effective for improving capsule excretion rate and reducing liquid loading.

DOI： 10.1111/den.13259

Prevalence and Correlates of Dyslipidemia Among Men and Women in Palau: Findings of the Palau STEPS Survey 2011-2013 査読有り国際共著

Cui, MS; Chiang, CF; Cui, RZ; Honjo, K; Yatsuya, H; Watson, BM; Ikerdeu, E; Mita, T; Madraisau, S; Aoyama, A; Iso, H

JOURNAL OF EPIDEMIOLOGY 29 巻 ( 3 ) 頁： 97 - 103 2019年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: Epidemiological evidence of dyslipidemia in Pacific Island countries is limited despite the knowledge that non-communicable diseases have a high burden in the region. We aimed to examine the prevalence and correlates of dyslipidemia among residents of Palau. Methods: The Palau STEPwise approach to Surveillance (STEPS), which was conducted from 2011 through 2013, comprised three parts: behavioral risk factors; physical measurements; and biochemical tests, covering areas such as blood lipids. We used STEPS-generated data to perform a cross-sectional study of 2,184 randomly selected Palau residents, comprising Palauans and non-Palauans aged 25–64 years. Results: The age-adjusted mean BMI was 29.3 kg/m 2 in men and 29.9 kg/m 2 in women; age-adjusted mean triglycerides value was 182 mg/dL in men and 166 mg/dL in women; and age-adjusted mean cholesterol was 178 mg/dL in men and 183 mg/dL in women. The prevalence of overweight/obesity (BMI ≥25 kg/m 2 ) was 75% in men and 76% in women, and those of hypertriglyceridemia (triglycerides ≥150 mg/dL) and hypercholesterolemia (total cholesterol ≥200 mg/dL) were 48% in men and 41% in women and 18% in men and 23% in women, respectively. Mean values of total cholesterol were 177 mg/dL in Palauan men and 182 mg/dL in non-Palauan men. Mean values of triglycerides were 171 mg/dL in Palauan women and 150 mg/dL in non-Palauan women. Women living in rural areas showed a higher mean value of total cholesterol than those in urban areas. Conclusion: We found a high mean BMI and high prevalence of overweight/obesity and hypertriglyceridemia, but low mean total cholesterol and a low prevalence of hypercholesterolemia in Palau. Lipid profiles varied by age, ethnicity, and living area.

DOI： 10.2188/jea.JE20170127

Sleep duration and risk of breast cancer: The JACC Study 査読有り

Cao, JH; Eshak, ES; Liu, KY; Muraki, I; Cui, RZ; Iso, H; Tamakoshi, A; Tamakoshi, A; Mori, M; Kaneko, Y; Tsuji, I; Nakamura, Y; Yamagishi, K; Mikami, H; Kurosawa, M; Hoshiyama, Y; Tanabe, N; Tamakoshi, K; Wakai, K; Tokudome, S; Suzuki, K; Hashimoto, S; Yatsuya, H; Kikuchi, S; Wada, Y; Kawamura, T; Watanabe, Y; Ozasa, K; Mikami, K; Date, C; Sakata, K; Kurozawa, Y; Yoshimura, T; Fujino, Y; Shibata, A; Okamoto, N; Shio, H

BREAST CANCER RESEARCH AND TREATMENT 174 巻 ( 1 ) 頁： 219 - 225 2019年2月

Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium 査読有り国際共著国際誌

Inker, LA; Grams, ME; Levey, AS; Coresh, J; Cirillo, M; Collins, JF; Gansevoort, RT; Gutierrez, OM; Hamano, T; Heine, GH; Ishikawa, S; Jee, SH; Kronenberg, F; Landray, MJ; Miura, K; Nadkarni, GN; Peralta, CA; Rothenbacher, D; Schaeffner, E; Sedaghat, S; Shlipak, MG; Zhang, LX; van Zuilen, AD; Hallan, S; Kovesdy, CP; Woodward, M; Levin, A; Astor, B; Appel, LJ; Greene, T; Chen, TK; Chalmers, J; Arima, H; Perkovic, V; Yatsuya, H; Tamakoshi, K; Li, YY; Hirakawa, Y; Matsushita, K; Grams, M; Sang, YY; Polldnghorne, K; Chadban, S; Atkins, R; Djurdjev, O; Liu, LS; Zhao, MH; Wang, F; Wang, JW; Ebert, N; Martus, P; Tang, ML; Heine, G; Emrich, I; Seiler, S; Zawada, A; Nally, J; Navaneethan, SD; Schold, JD; Zhao, MH; Sarnak, MJ; Katz, R; Hiramoto, J; Iso, H; Yamagishi, K; Umesawa, M; Murald, I; Fukagawa, M; Maruyama, S; Hasegawa, T; Fujii, N; Wheeler, DC; Emberson, J; Townend, J; Landray, M; Brenner, H; Schöttker, B; Saum, KU; Fox, C; Hwang, SJ; Köttgen, A; Schneider, MP; Eckardt, KU; Green, JA; Kirchner, HL; Chang, AR; Ho, K; Ito, S; Miyazaki, M; Nakayama, M; Yamada, G; Irie, F; Sairenchi, T; Yano, Y; Kotani, K; Nakamura, T; Kimm, H; Mok, Y; Chodick, G; Shalev, V; Wetzels, JFM; Blankestijn, PJ; van den Brand, JA; Sarnak, M; Peralta, C; Kollerits, B; Ritz, E; Nitsch, D; Roderick, P; Fletcher, A; Bottinger, E; Ellis, SB; Nadukuru, R; Ueshima, H; Okayama, A; Miura, K; Tanaka, S; Okamura, T; Kadota, A; Kenealy, T; Elley, CR; Drury, PL; Ohkubo, T; Asayama, K; Metold, H; Kikuya, M; Nelson, RG; Knowler, WC; Bakker, SJL; Hak, E; Heerspink, HJL; Brunskill, NJ; Major, RW; Shepherd, D; Medcalf, JF; Bernardo, R; Jassal, SK; Bergstrom, J; Ix, JH; Barrett-Connor, E; Kalantar-Zadeh, K; Sumida, K; Muntner, P; Warnock, D; McClellan, W; de Zeeuw, D; Brenner, B; Ikram, MA; Hoorn, EJ; Dehghan, A; Carrero, JJ; Gasparini, A; Wettermark, B; Elinder, CG; Wong, TY; Sabanayagam, C; Cheng, CY; Sokor, RBBMA; Visseren, FLJ; Evans, M; Segelmark, M; Stendahl, M; Schön, S; Tangri, N; Sud, M; Naimark, DM; Wen, CP; Tsao, CK; Tsai, MK; Chen, CH; Konta, T; Hirayama, A; Ichikawa, K; Lannfelt, L; Larsson, A; Ärnlöv, J; Bilo, HJG; Landman, GWD; van Hateren, KJJ; Kleefstra, N; Hallan, S; Ballew, SH; Chen, JS; Kwak, L; Surapaneni, A

AMERICAN JOURNAL OF KIDNEY DISEASES 73 巻 ( 2 ) 頁： 206 - 217 2019年2月

Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium 査読有り国際共著

Chang, AR; Grams, ME; Ballew, SH; Bilo, H; Correa, A; Evans, M; Gutierrez, OM; Hosseinpanah, F; Iseki, K; Kenealy, T; Klein, B; Kronenberg, F; Lee, BJ; Li, YY; Miura, K; Navaneethan, SD; Roderick, PJ; Valdivielso, JM; Visseren, FLJ; Zhang, LX; Gansevoort, RT; Hallan, SI; Levey, AS; Matsushita, K; Shalev, V; Woodward, M; Astor, B; Appel, L; Greene; Chen, T; Chalmers, J; Woodward, M; Arima, H; Perkovic, V; Yatsuya, H; Tamakoshi, K; Li, Y; Hirakawa, Y; Coresh, J; Matsushita, K; Grams, M; Sang, Y; Polkinghorne, K; Chadban, S; Atkins, R; Levin, A; Djurdjev, O; Dam, B; Klein, R; Klein, B; Lee, K; Zhang, LX; Liu, LS; Zhao, MH; Wang, F; Wang, JW; Levin, A; Djurdjev, O; Tang, M; Heine, G; Emrich, I; Zawada, A; Bauer, L; Nally, J; Navaneethan, S; Schold, J; Zhang, LX; Zhao, MH; Wang, F; Wang, JW; Shlipak, M; Sarnak, M; Katz, R; Hiramoto, J; Iso, H; Yamagishi, K; Umesawa, M; Muraki, I; Fukagawa, M; Maruyama, S; Hamano, T; Hasegawa, T; Fujii, N; Jafar, T; Hatcher, J; Poulter, N; Chaturvedi, N; Wheeler, D; Emberson, J; Townend, J; Landray, M; Hermann; Brenner; Schöttker, B; Saum, KU; Rothenbacher, D; Fox, C; Hwang, SJ; Köttgen, A; Kronenberg, F; Schneider, MP; Eckardt, KU; Green, J; Kirchner, HL; Chang, AR; Ito, S; Miyazaki, M; Nakayama, M; Yamada, G; Cirillo, M; Hallan, S; Romundstad, S; Ovrehus, M; Langlo, KA; Irie, F; Sairenchi, T; Correa, A; Rebholz, CM; Young, B; Boulware, LE; Ishikawa, S; Yano, Y; Kotani, K; Nakamura, T; Jee, SH; Kimm, H; Mok, Y; Lee, BJ; Chodick, G; Shalev, V; Wetzels, JFM; Blankestijn, PJ; van Zuilen, AD; Bots, M; Sarnak, M; Inker, L; Shlipak, M; Sarnak, M; Katz, R; Peralta, C; Kronenberg, F; Kollerits, B; Ritz, E; Nitsch, D; Roderick, P; Fletcher, A; Bottinger, E; Nadkarni, GN; Ellis, SB; Nadukuru, R; Valdivielso, JM; Fernandez, E; Betriu, A; Bermudez-Lopez, M; Stengel, B; Metzger, M; Flamant, M; Houillier, P; Haymann, JP; Froissart, M; Sang, YY; Ueshima, H; Okayama, A; Miura, K; Tanaka, S; Ueshima, H; Okamura, T; Miura, K; Tanaka, S; Kenealy, T; Elley, CR; Collins, JF; Drury, PL; Ohkubo, T; Asayama, K; Metoki, H; Kikuya, M; Nakayama, M; Iseki, K; Iseki, C; Nelson, RG; Knowler, WC; Gansevoort, RT; Bakker, SJL; Heerspink, HJL; Brunskill, N; Major, R; Shepherd, D; Medcalf, J; Bernardo, R; Jassal, SK; Bergstrom, J; Joachim, H; Barrett-Connor, E; Kovesdy, C; Kalantar-Zadeh, K; Sumida, K; Muntner, P; Warnock, D; Judd, S; Panwar, B; Heerspink, HJL; de Zeeuw, D; Brenner, B; Sedaghat, S; Ikram, MA; Hoorn, EJ; Dehghan, A; Wong, TY; Sabanayagam, C; Cheng, CY; Binte, RB; Sokor, MA; Visseren, FLJ; Evans, M; Segelmark, M; Stendahl, M; Schön, S; Tangri, N; Sud, M; Naimark, D; Wen, CP; Tsao, K; Tsai, MK; Chen, CH; Konta, T; Hirayama, A; Ichikawa, K; Hosseinpanah, F; Hadaegh, F; Mirbolouk, M; Azizi, F; Solbu, MD; Jenssen, TG; Eriksen, BO; Eggen, AE; Lannfelt, L; Larsson, A; Ärnlöv, J; Bilo, HJG; Landman, GWD; Van Hateren, KJJ; Kleefstra, N; Coresh, J; Gansevoort, RT; Grams, ME; Hallan, S; Kovesdy, CP; Levey, AS; Matsushita, K; Shalev, V; Woodward, M; Ballew, SH; Chen, JS; Coresh, J; Grams, ME; Kwak, L; Matsushita, K; Sang, YY; Surapaneni, A; Woodward, M

BMJ-BRITISH MEDICAL JOURNAL 364 巻 2019年1月

Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 査読有り国際共著国際誌

James, SL; Theadom, A; Ellenbogen, RG; Bannick, MS; Mountjoy-Venning, WC; Lucchesi, LR; Abbasi, N; Abdulkader, R; Abraha, HN; Adsuar, JC; Afarideh, M; Agrawal, S; Ahmadi, A; Ahmed, MB; Aichour, AN; Aichour, I; Aichour, MTE; Akinyemi, RO; Akseer, N; Alahdab, F; Alebel, A; Alghnam, SA; Ali, BA; Alsharif, U; Altirkawi, K; Andrei, CL; Anjomshoa, M; Ansari, H; Ansha, MG; Antonio, CAT; Appiah, SCY; Ariani, F; Asefa, NG; Asgedom, SW; Atique, S; Awasthi, A; Quintanilla, BPA; Ayuk, TB; Azzopardi, PS; Badali, H; Badawi, A; Balalla, S; Banstola, A; Barker-Collo, SL; Bärnighausen, TW; Bedi, N; Behzadifar, M; Behzadifar, M; Bekele, BB; Belachew, AB; Belay, YA; Bennett, DA; Bensenor, IM; Berhane, A; Beuran, M; Bhalla, A; Bhaumik, S; Bhutta, ZA; Biadgo, B; Biffino, M; Bijani, A; Bililign, N; Birungi, C; Boufous, S; Brazinova, A; Brown, AW; Car, M; Cárdenas, R; Carrero, JJ; Carvalho, F; Castañeda-Orjuela, CA; Catalá-López, F; Chaiah, Y; Champs, AP; Chang, JC; Choi, JYJ; Christopher, DJ; Cooper, C; Crowe, CS; Dandona, L; Dandona, R; Daryani, A; Davitoiu, DV; Degefa, MG; Demoz, GT; Deribe, K; Djalalinia, S; Do, HP; Doku, DT; Drake, TM; Dubey, M; Dubljanin, E; El-Khatib, Z; Eskandarieh, S; Esteghamati, A; Esteghamati, S; Faro, A; Farzadfar, F; Farzaei, MH; Fereshtehnejad, SM; Fernandes, E; Feyissa, GT; Filip, I; Fischer, F; Fukumoto, T; Ganji, M; Gankpe, FG; Gebre, AK; Gebrehiwot, TT; Gezae, KE; Gopalkrishna, G; Goulart, AC; Haagsma, JA; Haj-Mirzaian, A; Haj-Mirzaian, A; Hamadeh, RR; Hamidi, S; Haro, JM; Hassankhani, H; Hassen, HY; Havmoeller, R; Hawley, C; Hay, SI; Hegazy, MI; Hendrie, D; Henok, A; Hibstu, DT; Hoffman, HJ; Hole, MK; Rad, EH; Hosseini, SM; Hostiuc, S; Hu, G; Hussen, MA; Ilesanmi, OS; Irvani, SN; Jakovljevic, M; Jayaraman, S; Jha, RP; Jonas, JB; Jones, KM; Shushtari, ZJ; Jozwiak, JJ; Jürisson, M; Kabir, A; Kahsay, A; Kahssay, M; Kalani, R; Karch, A; Kasaeian, A; Kassa, GM; Kassa, TD; Kassa, ZY; Kengne, AP; Khader, YS; Khafaie, MA; Khalid, N; Khalil, I; Khan, EA; Khan, MS; Khang, YH; Khazaie, H; Khoja, AT; Khubchandani, J; Kiadaliri, AA; Kim, D; Kim, YE; Kisa, A; Koyanagi, A; Krohn, KJ; Defo, BK; Bicer, BK; Kumar, GA; Kumar, M; Lalloo, R; Lami, FH; Lansingh, VC; Laryea, DO; Latifi, A; Leshargie, CT; Levi, M; Li, SS; Liben, ML; Lotufo, PA; Lunevicius, R; Mahotra, NB; Majdan, M; Majeed, A; Malekzadeh, R; Manda, AL; Mansournia, MA; Massenburg, BB; Mate, KKV; Mehndiratta, MM; Mehta, V; Meles, H; Melese, A; Memiah, PTN; Mendoza, W; Mengistu, G; Meretoja, A; Meretoja, TJ; Mestrovic, T; Miazgowski, T; Miller, TR; Mini, GK; Mirica, A; Mirrakhimov, EM; Moazen, B; Mohammadi, M; Mokdad, AH; Molokhia, M; Monasta, L; Mondello, S; Moosazadeh, M; Moradi, G; Moradi, M; Moradi-Lakeh, M; Moradinazar, M; Morrison, SD; Moschos, MM; Mousavi, SM; Murthy, S; Musa, KI; Mustafa, G; Naghavi, M; Naik, G; Najafi, F; Nangia, V; Nascimento, BR; Negoi, I; Nguyen, TH; Nichols, E; Ningrum, DNA; Nirayo, YL; Nyasulu, PS; Ofori-Asenso, R; Ogbo, FA; Oh, IH; Okoro, A; Olagunju, AT; Olagunju, TO; Olivares, PR; Otstavnov, SS; Owolabi, MO; Mahesh, PA; Pakhale, S; Pandey, AR; Pesudovs, K; Pinilla-Monsalve, GD; Polinder, S; Poustchi, H; Prakash, S; Qorbani, M; Radfar, A; Rafay, A; Rafiei, A; Rahimi-Movaghar, A; Rahimi-Movaghar, V; Rahman, M; Rahman, MA; Rai, RK; Rajati, F; Ram, U; Rawaf, DL; Rawaf, S; Reiner, RC; Reis, C; Renzaho, AMN; Resnikoff, S; Rezaei, S; Rezaeian, S; Roever, L; Ronfani, L; Roshandel, G; Roy, N; Ruhago, GM; Saddik, B; Safari, H; Safiri, S; Sahraian, MA; Salamati, P; Saldanha, RD; Samy, AM; Sanabria, J; Santos, JV; Milicevic, MMMS; Sartorius, B; Satpathy, M; Schneider, IJC; Schwebel, DC; Sepanlou, SG; Shabaninejad, H; Shaikh, MAA; Shams-Beyranvand, M; Sharif, M; Sharif-Alhoseini, M; Islam, SMS; She, J; Sheikh, A; Shen, JB; Sheth, KN; Shibuya, K; Shiferaw, MS; Shigematsu, M; Shiri, R; Shiue, I; Shoman, H; Siabani, S; Siddiqi, TJ; Silva, JP; Silveira, DGA; Sinha, DN; Smith, M; Soares, AM; Sobhani, S; Soofi, M; Soriano, JB; Soyiri, IN; Stein, DJ; Stokes, MA; Sufiyan, MB; Sunguya, BF; Sunshine, JE; Sykes, BL; Szoeke, CEI; Tabares-Seisdedos, R; Ao, BJT; Tehrani-Banihashemi, A; Tekle, MG; Temsah, MH; Temsah, O; Topor-Madry, R; Tortajada-Girbés, M; Tran, BX; Tran, KB; Car, LT; Ukwaja, KN; Ullah, I; Usman, MS; Uthman, OA; Valdez, PR; Vasankari, TJ; Venketasubramanian, N; Violante, FS; Wagnew, FS; Waheed, Y; Wang, YP; Weldegwergs, KG; Werdecker, A; Wijeratne, T; Winkler, AS; Wyper, GMA; Yano, Y; Yaseri, M; Yasin, YJ; Ye, PP; Yimer, EM; Yip, P; Yisma, E; Yonemoto, N; Yoon, SJ; Yost, MG; Younis, MZ; Yousefifard, M; Yu, CH; Zaidi, Z; Bin Zaman, S; Zamani, M; Zenebe, ZM; Zodpey, S; Feigin, VL; Vos, T; Murray, CJL

LANCET NEUROLOGY 18 巻 ( 1 ) 頁： 56 - 87 2019年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：The Lancet Neurology

Background: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders. Methods: We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach. Findings: Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247–308]) and second leading cause of deaths (9·0 million [8·8–9·4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34–44] and DALYs by 15% [9–21]) whereas their age-standardised rates decreased (deaths by 28% [26–30] and DALYs by 27% [24–31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42·2% [38·6–46·1]), migraine (16·3% [11·7–20·8]), Alzheimer's and other dementias (10·4% [9·0–12·1]), and meningitis (7·9% [6·6–10·4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1·12 [1·05–1·20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0·7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88·8% (86·5–90·9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer's disease and other dementias (22·3% [11·8–35·1] of DALYs are risk attributable) and idiopathic epilepsy (14·1% [10·8–17·5] of DALYs are risk attributable). Interpretation: Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies. Funding: Bill & Melinda Gates Foundation.

DOI： 10.1016/S1474-4422(18)30415-0

Lifetime Risk of Stroke and Coronary Heart Disease Deaths According to Blood Pressure Level: EPOCH-JAPAN (Evidence for Cardiovascular Prevention From Observational Cohorts in Japan) 査読有り国際誌

Satoh, M; Ohkubo, T; Asayama, K; Murakami, Y; Sugiyama, D; Yamada, M; Saitoh, S; Sakata, K; Irie, F; Sairenchi, T; Ishikawa, S; Kiyama, M; Ohnishi, H; Miura, K; Imai, Y; Ueshima, H; Okamura, T; Iso, H; Kitamura, A; Ninomiya, T; Kiyohara, Y; Nakagawa, H; Nakayama, T; Okayama, A; Sairenchi, T; Tamakoshi, A; Tsuji, I; Miyamoto, Y; Ishikawa, S; Yatsuya, H; Okamura, T

HYPERTENSION 73 巻 ( 1 ) 頁： 52 - 59 2019年1月

Smoking results in accumulation of ectopic fat in the liver 査読有り国際誌

Kato, A; Li, YY; Ota, A; Naito, H; Yamada, H; Nihashi, T; Hotta, Y; Chiang, C; Hirakawa, Y; Aoyama, A; Tamakoshi, K; Yatsuya, H

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY 12 巻頁： 1075 - 1079 2019年

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Diabetes, Metabolic Syndrome and Obesity

Objective: An association between smoking and nonalcoholic fatty liver disease has been reported. However, objective quantification of intrahepatic fat via magnetic resonance spectroscopy (MRS) in relation to smoking has rarely been performed in previous studies. Moreover, the possible pathways via which smoking could induce ectopic fat accumulation have not yet been addressed. The current study aimed to examine the association between smoking status and intrahepatic fat quantity and explore the possible mediating effects of triglycerides (TG) and adiponectin. Subjects and methods: Magnetic resonance imager (MRI) spectra were analyzed to quantify intrahepatic fat in 45 men who were on average 62.3 years of age. Smoking status and alcohol intake were self-reported. Accelerometers were used to record daily total physical activity. Fasting blood TG and adiponectin levels were measured enzymatically. Differences in mean intrahepatic fat values according to smoking status were assessed using analysis of covariance. Results: A stepwise increase in mean intrahepatic fat was observed between never, former, and current smokers, respectively, independent of age, physical activity, alcohol intake, and body mass index (BMI) (P=0.005). Adjustment for TG and adiponectin significantly attenuated this association (P=0.074). Conclusion: Current smoking was significantly associated with increased intrahepatic fat, which may be a result of adipocyte dysfunction, manifested as high circulating TG concentrations and low adiponectin levels.

DOI： 10.2147/DMSO.S212495

Self-Reported Eczema in Relation with Mortality from Cardiovascular Disease in Japanese: the Japan Collaborative Cohort Study 査読有り

Nishida, Y; Kubota, Y; Iso, H; Tamakoshi, A; Tamakoshi, A; Mori, M; Kaneko, Y; Tsuji, I; Nakamura, Y; Iso, H; Yamagishi, K; Mikami, H; Kurosawa, M; Hoshiyama, Y; Tanabe, N; Tamakoshi, K; Wakai, K; Ando, M; Suzuki, K; Hashimoto, S; Yatsuya, H; Kikuchi, S; Wada, Y; Kawamura, T; Watanabe, Y; Ozasa, K; Mikami, K; Date, C; Sakata, K; Kurozawa, Y; Fujino, Y; Shibata, A

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 26 巻 ( 9 ) 頁： 775 - 782 2019年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Atherosclerosis and Thrombosis

Aim: Previous studies suggested a positive association between eczema and cardiovascular disease (CVD), probably through enhanced systemic inflammation. However, several studies reported null findings about eczema and CVD, so the evidence is still controversial. Methods: We asked 85,099 participants (35,489 men and 49,610 women), aged 40 to 79 years, without a history of CVD or cancer at baseline between 1988 and 1990, to complete a lifestyle questionnaire, including information eczema frequency (seldom, sometimes or often). Results: During the 6,389,818 person-years of follow-up, there were 1,174 deaths from coronary heart disease (CHD), 979 from heart failure, 366 from cardiac arrhythmia, 2,454 from total stroke, 1,357 from ischemic stroke, 1,013 from hemorrhagic stroke, and 201 from aortic aneurysm or dissection. The multivariable-adjusted model showed that individuals who “sometimes” or “often” had eczema had 0.82 (95%confidence interval (CI): 0.69–0.97) or 1.26 (95%CI: 1.01–1.56) times the risk of mortality from CHD, respectively, compared to those who “seldom” did. Individuals who “often” had 1.30 (95%CI: 1.05–1.61) times the risk of mortality from CHD, compared to those who “seldom or sometimes” did. There was no association of eczema with mortality from other CVD, or no interaction between eczema and sex or age, in relation to any CVD mortality risk. Conclusions: Self-reported frequent eczema was associated with increased risk of mortality from CHD, but not other major CVD, in a Japanese general population. Since steroid usage was not considered, future studies should include it as a potential confounding factor.

DOI： 10.5551/jat.46383

Web of Science

Scopus

PubMed

Smoking results in accumulation of ectopic fat in the liver. 査読有り

Smoking results in accumulation of, ectopic fat in, the, liver, Kato A, Li Y, Ota A, Naito H, Yamada H, Nihashi T, Hotta Y, Chiang C, Hirakawa Y, Aoyama A, Tamakoshi K, Yatsuya H

Diabetes Metab Syndr Obes 9 巻 ( 12 ) 頁： 1075 - 1080 2019年

Multicenter feasibility study of bowel preparation with castor oil for colon capsule endoscopy 査読有り国際誌

Ohmiya N., Hotta N., Mitsufuji S., Nakamura M., Omori T., Maeda K., Okuda K., Yatsuya H., Tajiri H.

Gastroenterological Endoscopy 61 巻 ( 12 ) 頁： 2646 - 2655 2019年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Gastroenterological Endoscopy

Background and Aim: Extensive use of laxatives and incomplete excretion rates are problematic for colon capsule endoscopy (CCE). The aim of the present study was to determine the effectiveness of castor oil as a booster. Methods: At four Japanese hospitals, 319 examinees undergoing CCE were enrolled retrospectively. Before and after the introduction of castor oil, other preparation reagents were unchanged. Results: Of 319 examinees who underwent CCE, 152 and 167 examinees took regimens with castor oil (between November 2013 and June 2016) and without castor oil (between October 2015 and September 2017), respectively. Capsule excretion rates within its battery life in the groups with and without castor oil were 97% and 81%, respectively (P＜0.0001). Multivariate analysis showed that ages younger than 65 years (adjusted odds ratio [OR], 3.00; P=0.0048), male gender (adjusted OR, 3.20; P=0.0051), and use of castor oil (adjusted OR, 6.29; P=0.0003) were predictors of capsule excretion within its battery life. Small bowel transit time was shorter and total volume of lavage and fluid intake was lower with castor oil than without (P = 0.0154 and 0.0013, respectively). Overall adequate cleansing level ratios with and without castor oil were 74% and 83%, respectively (P = 0.0713). Per-examinee sensitivity for polyps ≥ 6 mm with and without castor oil was 83% and 85%, respectively, with specificities of 80% and 78%, respectively. Conclusion: Bowel preparation with castor oil was effective for improving capsule excretion rate and reducing liquid loading.

DOI： 10.11280/gee.61.2646

Scopus

CiNii Research

Perception and practice of 'healthy' diet in relation to noncommunicable diseases among the urban and rural people in northern Ethiopia: a community-based qualitative study 査読有り国際共著

Gebremariam, LW; Aoyama, A; Kahsay, AB; Hirakawa, Y; Chiang, CF; Yatsuya, H; Matsuyama, A

NAGOYA JOURNAL OF MEDICAL SCIENCE 80 巻 ( 4 ) 頁： 451 - 464 2018年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nagoya Journal of Medical Science

Dietary habits are related to the risks of noncommunicable diseases (NCDs), such as cardiovascular disease and diabetes, of which burdens are increasing in low-income countries including Ethiopia. Although several epidemiological studies of NCD risk factors were conducted in Ethiopia, qualitative studies on people's dietary habit in relation to NCDs have not been conducted yet. This study aims to describe people's perception and practice of 'healthy' diet, and barriers to practice 'healthy' diet, paying attention to the dynamics between the perception and practice. We conducted 16 key informant interviews and eight focus group discussions in an urban and a rural areas in northern Ethiopia between November 2014 and January 2016. Audio-records in local language were transcribed word-for-word, and translated into English. English text data were analyzed qualitatively, through constant comparative analysis following the principles of the grounded theory. Three themes have emerged: (1) dietary habit perceived as 'good' or 'bad' for health; (2) reasons for continuing current 'unhealthy' dietary habit; and (3) current dietary habit perceived as 'traditional.' People's practice was mostly consistent with their perception, while they sometimes practiced contrary to the perception because of personal preference and physical or financial obstacles. People were often indifferent of health implications of their habitual dietary practice, such as drinking a lot of sweet coffee. We showed dynamics between perception and practice of 'healthy' diet among people in northern Ethiopia. It is needed to increase awareness of NCDs both among the urban and rural people and to improve the social environment for removing the obstacles.

DOI： 10.18999/nagjms.80.4.451

Perceptions and behavior related to noncommunicable diseases among slum dwellers in a rapidly urbanizing city, Dhaka, Bangladesh: a qualitative study 査読有り国際共著

Al-Shoaibi, AAA; Matsuyama, A; Khalequzzaman, M; Haseen, F; Choudhury, SR; Hoque, BA; Chiang, CF; Hirakawa, Y; Yatsuya, H; Aoyama, A

NAGOYA JOURNAL OF MEDICAL SCIENCE 80 巻 ( 4 ) 頁： 559 - 569 2018年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nagoya Journal of Medical Science

The increasing burden of noncommunicable diseases (NCDs) in Bangladesh can be attributable to rapid urbanization and coinciding changes in lifestyle accompanied by nutrition transition. The objective of this study is to explore respondents' lived experiences and perceptions relating to NCDs and nutrition change in an urban slum community in Dhaka. Qualitative methods were employed to explore a general understanding of behavior related to NCDs among residents of the slum community. We conducted key informant interviews of six men and seven women of various backgrounds and five focus group discussions to focus salient topics emerged from the interviews. The transcriptions of the audio-recordings were thematically analyzed, using the constant comparison method. Four major themes emerged: (1) financial hardship influencing health; (2) urbanized lifestyle affecting diet; (3) tobacco and sweetened tea as cornerstones of social life; and (4) health-seeking behavior utilizing local resources. One notable finding was that even with general economic improvement, respondents perceived poverty to be one of the major causes of NCDs. A promising finding for potentially curbing NCDs was the current trend for women to walk for exercise contrary to the commonly held notion that urban dwellers generally lead sedentary lifestyles. This study described how urban slum dwellers in Dhaka, experiencing a transition from a traditional to urbanized lifestyle, perceived their daily practices in relation to NCDs and nutrition. Our research revealed both adverse and encouraging elements of perceptions and behavior related to NCDs, which may contribute to the optimal design of NCD prevention and health promotion programs.

DOI： 10.18999/nagjms.80.4.559

Clinical course of human herpesvirus 6 infection in pediatric living donor liver transplantation 査読有り国際誌

Yasui, T; Suzuki, T; Yoshikawa, T; Yatsuya, H; Kawamura, Y; Miura, H; Hara, F; Watanabe, S; Uga, N; Naoe, A

PEDIATRIC TRANSPLANTATION 22 巻 ( 7 ) 頁： e13239 2018年11月

HYPERTENSION DETECTION, TREATMENT AND CONTROL RATES IN URBAN SLUM POPULATION IN BANGLADESH 査読有り国際共著

Choudhury, S; Al-Shoaibi, AAA; Khalequzzaman, M; Al Mamun, MA; Chiang, CF; Yatsuya, H; Aoyama, A

JOURNAL OF HYPERTENSION 36 巻頁： E337 - E338 2018年10月

Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study 査読有り国際誌

Kokubo, Y; Saito, I; Iso, H; Yamagishi, K; Yatsuya, H; Ishihara, J; Maruyama, K; Inoue, M; Sawada, N; Tsugane, S

CLINICAL NUTRITION 37 巻 ( 5 ) 頁： 1602 - 1608 2018年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Clinical Nutrition

Background & aims: The associations between dietary magnesium intake and stroke and coronary heart disease (CHD) incidences are inconsistent and not established in Asian. We aimed to determine the association between dietary magnesium intake and the risk of stroke and CHD in a Japanese population. Subjects/Methods: We studied 85,293 Japanese subjects by questionnaire at baseline (age 45–74 years, without cardiovascular disease or cancer in 1995 and 1998 for Cohorts I and II, respectively). The participants were followed until the end of 2009 and 2010 in Cohorts I and II, respectively. Dietary magnesium intake was estimated from a self-administered 138-item food-frequency questionnaire. Results: After 1,305,738 person-years of follow-up, 4110 strokes and 1283 cases of CHD were documented. The multivariable-adjusted hazard ratios (HRs, 95% confidence intervals, 95%CIs) of CHD for the fourth and fifth quintiles of dietary magnesium intake were 0.70 (0.50–0.99) and 0.66 (0.44–0.97) in men (P for trend = 0.036), respectively, and third quintile of dietary magnesium intake was 0.61 (0.39–0.96) in women (P for trend = 0.241), compared with the lowest quintile in men and women. We observed no decreased risks of incident stroke in men or women with higher dietary magnesium intakes. Conclusions: Higher dietary magnesium intake was associated with a reduced risk of CHD in Japanese men.

DOI： 10.1016/j.clnu.2017.08.006

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