研究者詳細 - 八谷　寛

論文 - 八谷　寛

分割表示 371 件中 161 - 180 件目／全件表示 >>

Non-High-Density Lipoprotein Cholesterol and Risk of Stroke Subtypes and Coronary Heart Disease The Japan Public Health Center-Based Prospective (JPHC) Study 査読有り

Saito, I; Yamagishi, K; Kokubo, Y; Yatsuya, H; Iso, H; Sawada, N; Inoue, M; Tsugane, S

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 27 巻 ( 4 ) 頁： 363 - 374 2020年

Depressive Tendency and the Risk of Death from Pneumonia: The JACC Study 査読有り

Tanabe, N; Seki, N; Horikawa, C; Yatsuya, H; Yamagishi, K; Iso, H; Ukawa, S; Tamakoshi, A

INTERNAL MEDICINE 59 巻 ( 24 ) 頁： 3123 - 3130 2020年

Cross-sectional association between working and depression prevalence in cancer survivors: a literature review 査読有り国際誌

Atsuhiko Ota, Kenji Kawada, Akizumi Tsutsumi, Hiroshi Yatsuya

Environmental and Occupational Health Practice 2 巻 ( 1 ) 頁： n/a - n/a 2020年

Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study 査読有り国際誌

Murai, U; Yamagishi, K; Sata, M; Kokubo, Y; Saito, I; Yatsuya, H; Ishihara, J; Inoue, M; Sawada, N; Iso, H; Tsugane, S

AMERICAN JOURNAL OF CLINICAL NUTRITION 110 巻 ( 6 ) 頁： 1449 - 1455 2019年12月

Association Between Body Mass Index and All-Cause Death in Japanese Population: Pooled Individual Participant Data Analysis of 13 Cohort Studies 査読有り Open Access

Hozawa, A; Hirata, T; Yatsuya, H; Murakami, Y; Kuriyama, S; Tsuji, I; Sugiyama, D; Satoh, A; Tanaka-Mizuno, S; Miura, K; Ueshima, H; Okamura, T

JOURNAL OF EPIDEMIOLOGY 29 巻 ( 12 ) 頁： 457 - 463 2019年12月

Diagnostic contribution of cytological examination to endobronchial ultrasound-guided transbronchial biopsy for lung malignancies 査読有り Open Access

Kajikawa, S; Imai, N; Okachi, S; Yatsuya, H; Souma, T; Watanabe, T; Goto, Y; Minezawa, T; Hashimoto, N; Imaizumi, K; Hasegawa, Y

NAGOYA JOURNAL OF MEDICAL SCIENCE 81 巻 ( 4 ) 頁： 613 - 620 2019年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nagoya Journal of Medical Science

Although endobronchial ultrasound guided transbronchial biopsy (TBB) with a guide sheath (EBUSGS) is widely used for diagnosis of peripheral pulmonary lesions, the diagnostic contribution of cytology (bronchial brushing, bronchial washing and biopsy forceps rinse) has not been established. To determine the diagnostic contribution of cytological examination to EBUS-GS-TBB, we reviewed medical records of patients with lung malignancies who had undergone TBB with EBUS-GS (EBUS-GS group, n=187) or TBB without EBUS-GS (conventional TBB [CTBB] group, n=197) at Nagoya University Hospital. Although the mean size of target lesions was significantly larger in the CTBB group than the EBUS-GS group, the total diagnostic rate was equivalent between two groups (EBUS-GS: 73.3%, CTBB: 66.0%). In the EBUS-GS group, cytological procedures increased the diagnostic rate by 9.1% (17/137), compared with only 4.1% (8/130) in the CTBB group. Sensitivity of cytology among biopsy-negative patients was significantly higher in EBUS-GS group than CTBB group (P=0.022). Furthermore, in the EBUS-GS group, among 17 patients whose malignant diagnoses could only be established cytologically, bronchial brushing contributed to the malignant diagnosis in 64.7% (11/17). These data may suggest that cytological examination, especially bronchial brushing, may be an important diagnostic contributor in EBUS-GS-TBB.

DOI： 10.18999/nagjms.81.4.613

Comparing different definitions of prediabetes with subsequent risk of diabetes: an individual participant data meta-analysis involving 76 513 individuals and 8208 cases of incident diabetes 査読有り国際共著国際誌 Open Access

Lee, CMY; Colagiuri, S; Woodward, M; Gregg, EW; Adams, R; Azizi, F; Gabriel, R; Gill, TK; Gonzalez, C; Hodge, A; Jacobs, DR ; Joseph, JJ; Khalili, D; Magliano, DJ; Mehlig, K; Milne, R; Mishra, G; Mongraw-Chaffin, M; Pasco, JA; Sakurai, M; Schreiner, PJ; Selvin, E; Shaw, JE; Wittert, G; Yatsuya, H; Huxley, RR

BMJ OPEN DIABETES RESEARCH & CARE 7 巻 ( 1 ) 頁： e000794 2019年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMJ Open Diabetes Research and Care

Objective There are currently five widely used definition of prediabetes. We compared the ability of these to predict 5-year conversion to diabetes and investigated whether there were other cut-points identifying risk of progression to diabetes that may be more useful. Research design and methods We conducted an individual participant meta-analysis using longitudinal data included in the Obesity, Diabetes and Cardiovascular Disease Collaboration. Cox regression models were used to obtain study-specific HRs for incident diabetes associated with each prediabetes definition. Harrell's C-statistics were used to estimate how well each prediabetes definition discriminated 5-year risk of diabetes. Spline and receiver operating characteristic curve (ROC) analyses were used to identify alternative cut-points. Results Sixteen studies, with 76 513 participants and 8208 incident diabetes cases, were available. Compared with normoglycemia, current prediabetes definitions were associated with four to eight times higher diabetes risk (HRs (95% CIs): 3.78 (3.11 to 4.60) to 8.36 (4.88 to 14.33)) and all definitions discriminated 5-year diabetes risk with good accuracy (C-statistics 0.79-0.81). Cut-points identified through spline analysis were fasting plasma glucose (FPG) 5.1 mmol/L and glycated hemoglobin (HbA1c) 5.0% (31 mmol/mol) and cut-points identified through ROC analysis were FPG 5.6 mmol/L, 2-hour postload glucose 7.0 mmol/L and HbA1c 5.6% (38 mmol/mol). Conclusions In terms of identifying individuals at greatest risk of developing diabetes within 5 years, using prediabetes definitions that have lower values produced non-significant gain. Therefore, deciding which definition to use will ultimately depend on the goal for identifying individuals at risk of diabetes.

DOI： 10.1136/bmjdrc-2019-000794

Television Viewing Time and Breast Cancer Incidence or Japanese Premenopausal and Postmenopausal Women: The JACC Study 査読有り Open Access

Cao, JH; Eshak, ES; Liu, KY; Muraki, I; Cui, RZ; Iso, H; Tamakoshi, A; Mori, M; Kaneko, Y; Tsuji, I; Nakamura, Y; Yamagishi, K; Mikami, H; Kurosawa, M; Hoshiyama, Y; Tanabe, N; Tamakoshi, K; Wakai, K; Tokudome, S; Suzuki, K; Hashimoto, S; Yatsuya, H; Kikuchi, S; Wada, Y; Kawamura, T; Watanabe, Y; Ozasa, K; Mikami, K; Date, C; Sakata, K; Yoshimura, T; Fujino, Y; Shibata, A; Okamoto, N; Shio, H; Kurozawa, Y

CANCER RESEARCH AND TREATMENT 51 巻 ( 4 ) 頁： 1509 - 1517 2019年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Cancer Research and Treatment

Purpose The evidence on effects of TV viewing time among premenopausal and postmenopausal women for breast cancer risk remains controversial and limited. Materials and Methods A prospective study encompassing 33,276 (17,568 premenopausal, and 15,708 postmenopausal) women aged 40-79 years in whom TV viewing time, menstrual, and reproductive histories were determined by a self-administered questionnaire. The follow-up was from 1988 to 2009 and hazard ratios (HRs) with 95% confidence intervals (CIs) of breast cancer incidence were calculated for longer TV viewing time in reference to shorter TV viewing time by Cox proportional hazard models. Results During 16.8-year median follow-up, we found positive associations between TV viewing time and breast cancer incidence with a borderline significant trend among total women and a significant trend among postmenopausal women. Among total women, the multivariable HRs (95% CIs) for risk of breast cancer in reference to < 1.5 hr/day of TV viewing time were 0.89 (0.59-1.34) for 1.5 to < 3.0 hr/day, 1.19 (0.82-1.74) for 3.0 to < 4.5 hr/day, and 1.45 (0.91-2.32) for ≥ 4.5 hr/day (p for trend=0.053) and among postmenopausal women, the corresponding risk estimates were 1.10 (0.42-2.88), 2.54 (1.11-5.80), and 2.37 (0.92-6.10) (p for trend=0.009), respectively. Conclusion Prolonged TV viewing time was associated with increased risk of breast cancer, especially among postmenopausal women.

DOI： 10.4143/crt.2018.705

The association between weight fluctuation and all-cause mortality A systematic review and meta-analysis 査読有り国際共著国際誌

Zhang, Y; Hou, FF; Li, JX; Yu, HY; Li, L; Hu, SL; Shen, GD; Yatsuya, H

MEDICINE 98 巻 ( 42 ) 頁： e17513 2019年10月

メタボリックシンドローム、空腹時血糖、腹囲身長比による6年後の2型糖尿病発症予測能査読有り

金子佳世, 八谷寛, 李媛英, 江啓発, 平川仁尚, 太田充彦, 玉腰浩司, 青山温子

日本公衆衛生学会総会抄録集 78回巻頁： 220 - 220 2019年10月

メタボリックシンドローム、空腹時血糖、腹囲身長比による6年後の2型糖尿病発症予測能

金子佳世, 八谷寛, 李媛英, 江啓発, 平川仁尚, 太田充彦, 玉腰浩司, 青山温子

日本公衆衛生学会総会抄録集 78回巻頁： 220 - 220 2019年10月

Body Mass Index and Risks of Incident Ischemic Stroke Subtypes: The Japan Public Health Center-Based Prospective (JPHC) Study. 査読有り国際誌 Open Access

Li Y, Yatsuya H, Iso H, Yamagishi K, Saito I, Kokubo Y, Sawada N, Tsugane S

Journal of epidemiology 29 巻 ( 9 ) 頁： 325 - 333 2019年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: The association of body mass index (BMI) with risks of ischemic stroke subtypes have not been established. Methods: Cumulative average BMI was calculated using self-reported body weight and height obtained from baseline (Cohort I in 1990, and Cohort II from 1993-1994) and 5- and 10-year questionnaire surveys of Japan Public Health Center-based prospective (JPHC) study. A total of 42,343 men and 46,413 women aged 40-69 years were followed-up for the incidence of lacunar, large-artery occlusive, and cardioembolic strokes. A sub-distribution hazard model was used to estimate subdistribution hazard ratios (SHRs) and the 95% confidence intervals (CIs). Results: During a median of 20.0 years of follow-up, we documented 809 and 481 lacunar, 395 and 218 large-artery occlusive, and 568 and 298 cardioembolic strokes in men and women, respectively. After adjustment for baseline age, updated smoking, alcohol consumption, leisure-time physical activity, and histories of hypertension, dyslipidemia, and diabetes mellitus, cumulative average BMI was positively linearly associated with lacunar (trend P = 0.007), large-artery occlusive (trend P = 0.002), and cardioembolic (trend P < 0.001) strokes in men, and with lacunar (trend P < 0.001) and large-artery occlusive (trend P = 0.003) strokes in women. There were approximately two-fold excess risk of cardioembolic stroke in both sexes and of lacunar and large-artery occlusive strokes in women for cumulative average BMI ≥30 kg=m2 compared to BMI 23-<25 kg=m2. Conclusion: Cumulative average BMI showed a positive linear effect on sub-distribution hazards of lacunar, large-artery occlusive, and cardioembolic strokes in both sexes, except for cardioembolic stroke in women.

DOI： 10.2188/jea.JE20170298

労働災害における休業見込期間と実休業日数の差異労働者死傷病報告と実休業日数との乖離

加藤善士, 太田充彦, 八谷寛

労働安全衛生研究 12 巻 ( 3 ) 頁： 173 - 179 2019年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：(独)労働者健康安全機構労働安全衛生総合研究所

労働基準監督署では，労働災害の重篤度を休業見込期間により判断し，労働災害防止施策を展開している．しかし，労働災害の休業が当初の休業見込期間を超えて長期に及ぶことがある．的確な労働災害防止施策を展開するためには，休業期間を早期に正確に把握することが重要となる．そこで某労働基準監督署管内の過去3 年間に発生した労働災害1,672件(男性1,204名，女性468名)について，事業場から報告される労働者死傷病報告と労働者災害補償内容を対比し，休業見込期間と実際の実休業日数の乖離状況を調べ，業種，事業場規模，性別，年齢，業務経験期間，平均賃金との関連を検討した．休業見込期間を超えて実際に休業した者の割合は男性で71.2%，女性で63.9%であった．休業見込期間（中央値：男性30日，女性28日）と実休業日数（中央値：男性50日，女性39日）は男性の方が長かった．休業見込期間を超えて休業する者の割合は，男性において事業場業種，事業場規模，年齢で有意な差が認められた．また，実休業日数／休業見込期間比の中央値は男性1.38，女性1.20と男女間で有意な差があった．労働災害の重篤度を休業見込期間で判断することは，重篤度を過小評価する可能性が高く，実休業日数が休業見込期間を超える割合には，男女で差があった．

DOI： 10.2486/josh.JOSH-2019-0009-CHO

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エチオピア北部の公務員における糖尿病および前糖尿病の危険因子(Risk factors of diabetes and prediabetes among public employees in northern Ethiopia) 国際共著

He Yupeng, Chiang Chifa, Gebremariam Lemlem W., Yatsuya Hiroshi, Hirakawa Yoshihisa, Aoyama Atsuko

国際保健医療 34 巻 ( 3 ) 頁： 140 - 141 2019年9月

High-fat and high-cholesterol diet decreases phosphorylated inositol-requiring kinase-1 and inhibits autophagy process in rat liver 査読有り国際誌 Open Access

Naito, H; Yoshikawa-Bando, Y; Yuan, Y; Hashimoto, S; Kitamori, K; Yatsuya, H; Nakajima, T

SCIENTIFIC REPORTS 9 巻 ( 1 ) 頁： 12514 - 12514 2019年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

Precise molecular pathways involved in the progression of non-alcoholic steatohepatitis (NASH) remain to be elucidated. As Mallory–Denk bodies were occasionally observed in the enlarged hepatocytes in NASH model rat (SHRSP5/Dmcr) fed high-fat and high-cholesterol (HFC) diet, we aimed to clarify the roles of autophagy and endoplasmic reticulum (ER) stress in NASH progression. Male SHRSP5/Dmcr were randomly divided into 4 groups. Two groups were fed a control diet; the other two groups were fed a HFC diet for 2 and 8 weeks, respectively. The HFC diet increased the autophagy-related proteins levels and microtubule-associated protein 1 light chain 3-II/I ratio after 2 and 8 weeks, respectively. However, regarding ER stress-related proteins, the HFC diet decreased the levels of phosphorylated (p-) inositol-requiring kinase-1 (p-IRE-1) and p-protein kinase RNA-like ER kinase after 2 weeks. Additionally, the HFC diet increased anti-ubiquitin-positive cells and the level of the autophagy substrate p62, suggesting that the HFC diet induced dysfunction in ubiquitin-dependent protein degradation pathways. In conclusion, the HFC diet arrested the autophagy process in the liver; this was particularly associated with decreases in p-IRE-1 expression.

DOI： 10.1038/s41598-019-48973-w

Automated Feedback Messages With Shichifukujin Characters Using IoT System-Improved Glycemic Control in People With Diabetes: A Prospective, Multicenter Randomized Controlled Trial. 査読有り国際誌

Kobayashi T, Tsushita K, Nomura E, Muramoto A, Kato A, Eguchi Y, Onoue T, Goto M, Muto S, Yatsuya H, Arima H

Journal of diabetes science and technology 13 巻 ( 4 ) 頁： 796 - 798 2019年7月

Associations of Daily Walking Time With Pneumonia Mortality Among Elderly Individuals With or Without a Medical History of Myocardial Infarction or Stroke: Findings From the Japan Collaborative Cohort Study 査読有り Open Access

Ukawa, S; Zhao, WJ; Yatsuya, H; Yamagishi, K; Tanabe, N; Iso, H; Tamakoshi, A; Mori, M; Sakauchi, F; Motohashi, Y; Tsuji, I; Nakamura, Y; Iso, H; Mikami, H; Kurosawa, M; Hoshiyama, Y; Tanabe, N; Tamakoshi, K; Wakai, K; Tokudome, S; Suzuki, K; Hashimoto, S; Kikuchi, S; Wada, Y; Kawamura, T; Watanabe, Y; Ozasa, K; Miki, T; Date, C; Sakata, K; Kurozawa, Y; Yoshimura, T; Fujino, Y; Shibata, A; Okamoto, N; Shio, H

JOURNAL OF EPIDEMIOLOGY 29 巻 ( 6 ) 頁： 233 - 237 2019年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: The association between daily walking and pneumonia mortality, stratified by the presence of disease conditions, such as myocardial infarction (MI) or stroke, was investigated. Methods: The study participants were 22,280 Japanese individuals (9,067 men and 13,213 women) aged 65-79 years. Inverse propensity weighted competing risk model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for pneumonia mortality. Results: After a median of 11.9 years of follow-up, 1,203 participants died of pneumonia. Participants who did not have a history of MI or stroke and who walked for 1 hour=day or more were less likely to die from pneumonia (HR 0.90; 95% CI, 0.82-0.98) than those walked for 0.5 hours=day. A similar inverse association of pneumonia and walking (0.5 hours=day) was observed among participants with a history of MI (HR 0.66; 95% CI, 0.48-0.90). Among the participants with a history of stroke, those who walked for 0.6-0.9 hours=day were less likely to die because of pneumonia (HR 0.65; 95% CI, 0.43-0.98). Conclusions: Regular walking for?1 hour=day may reduce the risk of pneumonia mortality in elderly individuals with or without cardiovascular disease history.

DOI： 10.2188/jea.JE20170341

Socioeconomic and lifestyle factors associated with depressive tendencies in general Japanese men and women: NIPPON DATA2010 査読有り国際誌 Open Access

Suzuki, H; Kadota, A; Okuda, N; Hayakawa, T; Nishi, N; Nakamura, Y; Arima, H; Miyagawa, N; Satoh, A; Miyamatsu, N; Yanagita, M; Yatsuya, H; Yamagata, Z; Ohkubo, T; Okamura, T; Ueshima, H; Okayama, A; Miura, K

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE 24 巻 ( 1 ) 頁： 37 - 37 2019年5月

Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 査読有り国際共著国際誌 Open Access

Johnson, CO; Nguyen, M; Roth, GA; Nichols, E; Alam, T; Abate, D; Abd-Allah, F; Abdelalim, A; Abraha, HN; Abu-Rmeileh, NM; Adebayo, OM; Adeoye, AM; Agarwal, G; Agrawal, S; Aichour, AN; Aichour, I; Aichour, MTE; Alahdab, F; Ali, R; Alvis-Guzman, N; Anber, NH; Anjomshoa, M; Arabloo, J; Arauz, A; Ärnlöv, J; Arora, A; Awasthi, A; Banach, M; Barboza, MA; Barker-Collo, SL; Bärnighausen, TW; Basu, S; Belachew, AB; Belayneh, YM; Bennett, DA; Bensenor, IM; Bhattacharyya, K; Biadgo, B; Bijani, A; Bikbov, B; Bin Sayeed, MS; Butt, ZA; Cahuana-Hurtado, L; Carrero, JJ; Carvalho, F; Castañeda-Orjuela, CA; Castro, F; Catalá-López, F; Chaiah, Y; Chiang, PPC; Choi, JYJ; Christensen, H; Chu, DT; Cortinovis, M; Damasceno, AAM; Dandona, L; Dandona, R; Daryani, A; Davletov, K; De Courten, B; De la Cruz-Góngora, V; Degefa, MG; Dharmaratne, SD; Diaz, D; Dubey, M; Duken, EE; Edessa, D; Endres, M; Faraon, EJA; Farzadfar, F; Fernandes, E; Fischer, F; Flor, LS; Ganji, M; Gebre, AK; Gebremichael, TG; Geta, B; Gezae, KE; Gill, PS; Gnedovskaya, EV; Gómez-Dantés, H; Goulart, AC; Grosso, G; Guo, YM; Gupta, R; Haj-Mirzaian, A; Haj-Mirzaian, A; Hamidi, S; Hankey, GJ; Hassen, HY; Hay, SI; Hegazy, MI; Heidari, B; Herial, NA; Hosseini, MA; Hostiuc, S; Irvani, SSN; Islam, SMS; Jahanmehr, N; Javanbakht, M; Jha, RP; Jonas, JB; Józwiak, JJ; Jürisson, M; Kahsay, A; Kalani, R; Kalkonde, Y; Kamil, TA; Kanchan, T; Karch, A; Karimi, N; Karimi-Sari, H; Kasaeian, A; Kassa, TD; Kazemeini, H; Kefale, AT; Khader, YS; Khalil, IA; Khan, EA; Khang, YH; Khubchandani, J; Kim, D; Kim, YJ; Kisa, A; Kivimäki, M; Koyanagi, A; Krishnamurthi, RK; Kumar, GA; Lafranconi, A; Lewington, S; Li, SS; Lo, WD; Lopez, AD; Lorkowski, S; Lotufo, PA; Mackay, MT; Majdan, M; Majdzadeh, R; Majeed, A; Malekzadeh, R; Manafi, N; Mansournia, MA; Mehndiratta, MM; Mehta, V; Mengistu, G; Meretoja, A; Meretoja, TJ; Miazgowski, B; Miazgowski, T; Miller, TR; Mirrakhimov, EM; Mohajer, B; Mohammad, Y; Mohammadoo-Khorasani, M; Mohammed, S; Mohebi, F; Mokdad, AH; Mokhayeri, Y; Moradi, G; Morawska, L; Velásquez, IM; Mousavi, SM; Muhammed, OSS; Muruet, W; Naderi, M; Naghavi, M; Naik, G; Nascimento, BR; Negoi, RI; Nguyen, CT; Nguyen, LH; Nirayo, YL; Norrving, B; Noubiap, JJ; Ofori-Asenso, R; Ogbo, FA; Olagunju, AT; Olagunju, TO; Owolabi, MO; Pandian, JD; Patel, S; Perico, N; Piradov, MA; Polinder, S; Postma, MJ; Poustchi, H; Prakash, V; Qorbani, M; Rafiei, A; Rahim, F; Rahimi, K; Rahimi-Movaghar, V; Rahman, M; Rahman, MA; Reis, C; Remuzzi, G; Renzaho, AMN; Ricci, S; Roberts, NLS; Robinson, SR; Roever, L; Roshandel, G; Sabbagh, P; Safari, H; Safari, S; Safiri, S; Sahebkar, A; Zahabi, SS; Samy, AM; Santalucia, P; Santos, IS; Santos, JV; Milicevic, MMS; Sartorius, B; Sawant, AR; Schutte, AE; Sepanlou, SG; Shafieesabet, A; Shaikh, MA; Shams-Beyranvand, M; Sheikh, A; Sheth, KN; Shibuya, K; Shigematsu, M; Shin, MJ; Shiue, I; Siabani, S; Sobaih, BH; Sposato, LA; Sutradhar, I; Sylaja, PA; Szoeke, CEI; Ao, BJT; Temsah, MH; Temsah, O; Thrift, AG; Tonelli, M; Topor-Madry, R; Tran, BX; Tran, KB; Truelsen, TC; Tsadik, AG; Ullah, I; Uthman, OA; Vaduganathan, M; Valdez, PR; Vasankari, TJ; Vasanthan, R; Venketasubramanian, N; Vosoughi, K; Vu, GT; Waheed, Y; Weiderpass, E; Weldegwergs, KG; Westerman, R; Wolfe, CDA; Wondafrash, DZ; Xu, GL; Yadollahpour, A; Yamada, T; Yatsuya, H; Yimer, EM; Yonemoto, N; Yousefifard, M; Yu, CH; Zaidi, Z; Zamani, M; Zarghi, A; Zhang, YQ; Zodpey, S; Feigin, VL; Vos, T; Murray, CJL

LANCET NEUROLOGY 18 巻 ( 5 ) 頁： 439 - 458 2019年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Lancet Neurology

Background: Stroke is a leading cause of mortality and disability worldwide and the economic costs of treatment and post-stroke care are substantial. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic, comparable method of quantifying health loss by disease, age, sex, year, and location to provide information to health systems and policy makers on more than 300 causes of disease and injury, including stroke. The results presented here are the estimates of burden due to overall stroke and ischaemic and haemorrhagic stroke from GBD 2016. Methods: We report estimates and corresponding uncertainty intervals (UIs), from 1990 to 2016, for incidence, prevalence, deaths, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs). DALYs were generated by summing YLLs and YLDs. Cause-specific mortality was estimated using an ensemble modelling process with vital registration and verbal autopsy data as inputs. Non-fatal estimates were generated using Bayesian meta-regression incorporating data from registries, scientific literature, administrative records, and surveys. The Socio-demographic Index (SDI), a summary indicator generated using educational attainment, lagged distributed income, and total fertility rate, was used to group countries into quintiles. Findings: In 2016, there were 5·5 million (95% UI 5·3 to 5·7) deaths and 116·4 million (111·4 to 121·4) DALYs due to stroke. The global age-standardised mortality rate decreased by 36·2% (−39·3 to −33·6) from 1990 to 2016, with decreases in all SDI quintiles. Over the same period, the global age-standardised DALY rate declined by 34·2% (−37·2 to −31·5), also with decreases in all SDI quintiles. There were 13·7 million (12·7 to 14·7) new stroke cases in 2016. Global age-standardised incidence declined by 8·1% (−10·7 to −5·5) from 1990 to 2016 and decreased in all SDI quintiles except the middle SDI group. There were 80·1 million (74·1 to 86·3) prevalent cases of stroke globally in 2016; 41·1 million (38·0 to 44·3) in women and 39·0 million (36·1 to 42·1) in men. Interpretation: Although age-standardised mortality rates have decreased sharply from 1990 to 2016, the decrease in age-standardised incidence has been less steep, indicating that the burden of stroke is likely to remain high. Planned updates to future GBD iterations include generating separate estimates for subarachnoid haemorrhage and intracerebral haemorrhage, generating estimates of transient ischaemic attack, and including atrial fibrillation as a risk factor. Funding: Bill & Melinda Gates Foundation

DOI： 10.1016/S1474-4422(19)30034-1

Association of gamma-glutamyl transferase and alanine aminotransferase with type 2 diabetes mellitus incidence in middle-aged Japanese men: 12-year follow up 査読有り Open Access

Kaneko, K; Yatsuya, H; Li, YY; Uemura, M; Chiang, CF; Hirakawa, Y; Ota, A; Tamakoshi, K; Aoyama, A

JOURNAL OF DIABETES INVESTIGATION 10 巻 ( 3 ) 頁： 837 - 845 2019年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Diabetes Investigation

Aims/Introduction: To prospectively investigate whether simultaneous elevation of gamma-glutamyl transferase (GGT) and alanine aminotransferase (ALT) is associated with the increase of type 2 diabetes mellitus incidence independent of alcohol drinking, body mass index and triglycerides. Methods: A total of 2,775 Japanese male workers who had no history of type 2 diabetes mellitus were followed. High GGT and ALT were defined as the top tertiles (GGT cutpoint: 49 IU/L, ALT cutpoint: 28 IU/L). Three groups were created using these dichotomized GGT and ALT cutpoints: both low, either high or both high. Multivariable Cox proportional hazards models were carried out adjusted for potential confounding factors. Results: A total of 276 type 2 diabetes mellitus cases were identified during 12 years (27,040 person-years) of follow up. Participants with simultaneously elevated GGT and ALT had a significantly higher incidence of type 2 diabetes mellitus, even after adjustment for fasting insulin and fasting blood glucose compared with the group without GGT or ALT elevation. Similar associations were observed in non- or light-to-moderate alcohol drinkers, as well as in participants with normal weight. However, the association was weaker in participants with triglycerides <150 mg/dL. We then evaluated whether the addition of GGT and ALT would improve the prediction of type 2 diabetes mellitus incidence, and found that their inclusion significantly increased the C-statistic, net reclassification improvement and integrated discrimination improvement. Conclusions: Simultaneous elevation of GGT and ALT was significantly associated with type 2 diabetes mellitus incidence, independent of potential confounding factors, including alcohol drinking and obesity, although the association might require concomitant elevation of triglycerides. Inclusion of GGT and ALT improved type 2 diabetes mellitus risk prediction.

DOI： 10.1111/jdi.12930

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