研究者詳細 - 八谷　寛

論文 - 八谷　寛

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The association of work-related stress with aggravation of pre-existing disease during COVID-19 emergency in Japan

He, YP; Yatsuya, H; Chiang, C; Ota, A; Okubo, R; Ishimaru, T; Tabuchi, T

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 50 巻 2021年9月

小学2年非肥満児における男女別の推定食塩摂取量、尿中Na/K比と収縮期血圧の関連

金子佳世, 伊藤由起, 加藤沙耶香, 玉田葉月, 松木太郎, 榎原毅, 井上貴子, 杉浦真弓, 齋藤伸治, 八谷寛, 藤田直也, 上島通浩

東海公衆衛生雑誌 9 巻 ( 1 ) 頁： 49 - 49 2021年7月

Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019 査読有り国際共著国際誌

Reitsma, MB; Reitsma, MB; Kendrick, PJ; Ababneh, E; Abbafati, C; Abbasi-Kangevari, M; Abdoli, A; Abedi, A; Abhilash, ES; Abila, DB; Aboyans, V; Abu-Rmeileh, NME; Adebayo, OM; Advani, SM; Aghaali, M; Ahinkorah, BO; Ahmad, S; Ahmadi, K; Ahmed, H; Aji, B; Akunna, CJ; Al-Aly, Z; Alanzi, TM; Alhabib, KF; Ali, L; Alif, SM; Alipour, V; Aljunid, SM; Alla, F; Allebeck, P; Alvis-Guzman, N; Amin, TT; Amini, S; Amu, H; Amul, GGH; Ancuceanu, R; Anderson, JA; Ansari-Moghaddam, A; Antonio, CAT; Antony, B; Anvari, D; Arabloo, J; Arian, ND; Arora, M; Asaad, M; Ausloos, M; Awan, AT; Ayano, G; Aynalem, GL; Azari, S; Darshan, BB; Badiye, AD; Baig, AA; Bakhshaei, MH; Banach, M; Banik, PC; Barker-Collo, SL; Bärnighausen, TW; Barqawi, HJ; Basu, S; Bayati, M; Bazargan-Hejazi, S; Behzadifar, M; Bekuma, TT; Bennett, DA; Bensenor, IM; Berfield, KSS; Bhagavathula, AS; Bhardwaj, N; Bhardwaj, P; Bhattacharyya, K; Bibi, S; Bijani, A; Bintoro, BS; Biondi, A; Birara, S; Braithwaite, D; Brenner, H; Brunoni, AR; Burkart, K; Butt, ZA; dos Santos, FLC; Cámera, LA; Car, J; Cárdenas, R; Carreras, G; Carrero, JJ; Castaldelli-Maia, JM; Cattaruzza, MSS; Chang, JC; Chen, SM; Chu, DT; Chung, SC; Cirillo, M; Costa, VM; Couto, RAS; Dadras, O; Dai, XC; Damasceno, AAM; Damiani, G; Dandona, L; Dandona, R; Daneshpajouhnejad, P; Gela, JD; Davletov, K; Molla, MD; Dessie, GA; Desta, AA; Dharmaratne, SD; Dianatinasab, M; Diaz, D; Do, HT; Douiri, A; Duncan, BB; Duraes, AR; Eagan, AW; Kalan, ME; Edvardsson, K; Elbarazi, I; El Tantawi, M; Esmaeilnejad, S; Fadhil, I; Faraon, EJA; Farinha, CSES; Farwati, M; Farzadfar, F; Fazlzadeh, M; Feigin, VL; Feldman, R; Prendes, CF; Ferrara, P; Filip, I; Filippidis, F; Fischer, F; Flor, LS; Foigt, NA; Folayan, MO; Foroutan, M; Gad, MM; Gaidhane, AM; Gallus, S; Geberemariyam, BS; Ghafourifard, M; Ghajar, A; Ghashghaee, A; Giampaoli, S; Gill, PS; Glozah, FN; Gnedovskaya, EV; Golechha, M; Gopalani, SV; Gorini, G; Goudarzi, H; Goulart, AC; Greaves, F; Guha, A; Guo, YM; Gupta, B; Das Gupta, R; Gupta, R; Gupta, T; Gupta, V; Hafezi-Nejad, N; Haider, MR; Hamadeh, RR; Hankey, GJ; Hargono, A; Hartono, RK; Hassankhani, H; Hay, SI; Heidari, G; Herteliu, C; Hezam, K; Hird, TR; Hole, MK; Holla, R; Hosseinzadeh, M; Hostiuc, S; Househ, M; Hsiao, T; Huang, JJ; Iannucci, VC; Ibitoye, SE; Idrisov, B; Ilesanmi, OS; Ilic, IM; Ilic, MD; Inbaraj, LR; Irvani, SSN; Islam, JY; Islam, RM; Islam, SMS; Islami, F; Iso, H; Itumalla, R; Iwagami, M; Jaafari, J; Jain, V; Jakovljevic, M; Jang, SI; Janjani, H; Jayaram, S; Jeemon, P; Jha, RP; Jonas, JB; Joo, T; Jürisson, M; Kabir, A; Kabir, Z; Kalankesh, LR; Kanchan, T; Kandel, H; Kapoor, N; Karimi, SE; Katikireddi, SV; Kebede, HK; Kelkay, B; Kennedy, RD; Khoja, AT; Khubchandani, J; Kim, GR; Kim, YE; Kimokoti, RW; Kivimäki, M; Kosen, S; Laxminarayana, SLK; Koyanagi, A; Krishan, K; Kugbey, N; Kumar, GA; Kumar, N; Kurmi, OP; Kusuma, D; Lacey, B; Lam, JO; Landires, I; Lasrado, S; Lauriola, P; Lee, DW; Lee, YH; Leung, JN; Li, SS; Lin, HL; Linn, S; Liu, W; Lopez, AD; Lopukhov, PD; Lorkowski, S; Lugo, A; Majeed, A; Maleki, A; Malekzadeh, R; Malta, DC; Mamun, AA; Manjunatha, N; Mansouri, B; Mansournia, MA; Martinez-Raga, J; Martini, S; Mathur, MR; Medina-Solís, CE; Mehata, S; Mendoza, W; Menezes, RG; Meretoja, A; Meretoja, TJ; Miazgowski, B; Michalek, IM; Miller, TR; Mirrakhimov, EM; Mirzaei, H; Mirzaei-Alavijeh, M; Misra, S; Moghadaszadeh, M; Mohammad, Y; Mohammadian-Hafshejani, A; Mohammed, S; Mokdad, AH; Monasta, L; Moni, MA; Moradi, G; Moradi-Lakeh, M; Moradzadeh, R; Morrison, SD; Mossie, TB; Mubarik, S; Mullany, EC; Murray, CJL; Naghavi, M; Naghshtabrizi, B; Nair, S; Nalini, M; Nangia, V; Naqvi, AA; Swamy, SN; Naveed, M; Nayak, S; Nayak, VC; Nazari, J; Nduaguba, SO; Kandel, SN; Nguyen, CT; Nguyen, HLT; Nguyen, SH; Nguyen, TH; Nixon, MR; Nnaji, CA; Norrving, B; Noubiap, JJ; Nowak, C; Ogbo, FA; Oguntade, AS; Oh, IH; Olagunju, AT; Oren, E; Otstavnov, N; Otstavnov, SS; Owolabi, MO; Pakhale, MPAS; Pakshir, K; Palladino, R; Pana, A; Panda-Jonas, S; Pandey, A; Parekh, U; Park, EC; Park, EK; Kan, FP; Patton, GC; Pawar, S; Pestell, RG; Pinheiro, M; Piradov, MA; Pirouzpanah, S; Pokhrel, KN; Polibin, RV; Prashant, A; Pribadi, DRA; Radfar, A; Rahimi-Movaghar, V; Rahman, A; Rahman, MHU; Rahman, MA; Rahmani, AM; Rajai, N; Ram, P; Ranabhat, CL; Rathi, P; Rawal, L; Renzaho, AMN; Reynales-Shigematsu, LM; Rezapour, A; Riahi, SM; Riaz, MA; Roever, L; Ronfani, L; Roshandel, G; Roy, A; Roy, B; Sacco, S; Saddik, B; Sahebkar, A; Salehi, S; Salimzadeh, H; Samaei, M; Samy, AM; Santos, IS; Santric-Milicevic, MM; Sarrafzadegan, N; Sathian, B; Sawhney, M; Saylan, M; Schaub, MP; Schmidt, MI; Schneider, IJC; Schutte, AE; Schwendicke, F; Seidu, AA; Kumar, NS; Sepanlou, SG; Seylani, A; Shafaat, O; Shah, SM; Shaikh, MA; Shalash, AS; Shannawaz, M; Sharafi, K; Sheikh, A; Sheikhbahaei, S; Shigematsu, M; Shiri, R; Shishani, K; Shivakumar, KM; Shivalli, S; Shrestha, R; Siabani, S; Sidemo, NB; Sigfusdottir, ID; Sigurvinsdottir, R; Silva, DAS; Silva, JP; Singh, A; Singh, JA; Singh, V; Sinha, DN; Sitas, F; Skryabin, VY; Skryabina, AA; Soboka, M; Soriano, JB; Soroush, A; Soshnikov, S; Soyiri, IN; Spurlock, EE; Sreeramareddy, CT; Stein, DJ; Steiropoulos, P; Stortecky, S; Straif, K; Abdulkader, RS; Sulo, G; Sundström, J; Tabuchi, T; Tadakamadla, SK; Taddele, BW; Tadesse, EG; Tamiru, AT; Tareke, M; Tareque, MI; Tarigan, IU; Temsah, MH; Thankappan, KR; Thapar, R; Tichopad, A; Tolani, MA; Topouzis, F; Tovani-Palone, MR; Tran, BX; Tripathy, JP; Tsegaye, GW; Tsilimparis, N; Tymeson, HD; Ullah, A; Ullah, S; Unim, B; Updike, RL; Vacante, M; Valdez, PR; Vardavas, C; Pérez, PV; Vasankari, TJ; Venketasubramanian, N; Verma, M; Vetrova, MV; Vo, B; Vu, GT; Waheed, Y; Wang, YZ; Welding, K; Werdecker, A; Whisnant, JL; Wickramasinghe, ND; Yamagishi, K; Yandrapalli, S; Yatsuya, H; Yazdi-Feyzabadi, V; Yeshaw, Y; Yimmer, MZ; Yonemoto, N; Yu, CH; Yunusa, I; Yusefzadeh, H; Moghadam, TZ; Zaman, MS; Zamanian, M; Zandian, H; Zar, HJ; Zastrozhin, MS; Zastrozhina, A; Zavala-Arciniega, L; Zhang, JR; Zhang, ZJ; Zhong, CW; Zuniga, YMH; Gakidou, E

LANCET 397 巻 ( 10292 ) 頁： 2337 - 2360 2021年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：The Lancet

Background: Ending the global tobacco epidemic is a defining challenge in global health. Timely and comprehensive estimates of the prevalence of smoking tobacco use and attributable disease burden are needed to guide tobacco control efforts nationally and globally. Methods: We estimated the prevalence of smoking tobacco use and attributable disease burden for 204 countries and territories, by age and sex, from 1990 to 2019 as part of the Global Burden of Diseases, Injuries, and Risk Factors Study. We modelled multiple smoking-related indicators from 3625 nationally representative surveys. We completed systematic reviews and did Bayesian meta-regressions for 36 causally linked health outcomes to estimate non-linear dose-response risk curves for current and former smokers. We used a direct estimation approach to estimate attributable burden, providing more comprehensive estimates of the health effects of smoking than previously available. Findings: Globally in 2019, 1·14 billion (95% uncertainty interval 1·13–1·16) individuals were current smokers, who consumed 7·41 trillion (7·11–7·74) cigarette-equivalents of tobacco in 2019. Although prevalence of smoking had decreased significantly since 1990 among both males (27·5% [26·5–28·5] reduction) and females (37·7% [35·4–39·9] reduction) aged 15 years and older, population growth has led to a significant increase in the total number of smokers from 0·99 billion (0·98–1·00) in 1990. Globally in 2019, smoking tobacco use accounted for 7·69 million (7·16–8·20) deaths and 200 million (185–214) disability-adjusted life-years, and was the leading risk factor for death among males (20·2% [19·3–21·1] of male deaths). 6·68 million [86·9%] of 7·69 million deaths attributable to smoking tobacco use were among current smokers. Interpretation: In the absence of intervention, the annual toll of 7·69 million deaths and 200 million disability-adjusted life-years attributable to smoking will increase over the coming decades. Substantial progress in reducing the prevalence of smoking tobacco use has been observed in countries from all regions and at all stages of development, but a large implementation gap remains for tobacco control. Countries have a clear and urgent opportunity to pass strong, evidence-based policies to accelerate reductions in the prevalence of smoking and reap massive health benefits for their citizens. Funding: Bloomberg Philanthropies and the Bill & Melinda Gates Foundation.

DOI： 10.1016/S0140-6736(21)01169-7

Web of Science

Scopus

PubMed

What constitutes healthiness of Washoku or Japanese diet? 招待有り国際誌

Yatsuya, H; Tsugane, S

EUROPEAN JOURNAL OF CLINICAL NUTRITION 75 巻 ( 6 ) 頁： 863 - 864 2021年6月

Predictive risk factors for pneumothorax after transbronchial biopsy using endobronchial ultrasonography with a guide sheath 査読有り国際誌

Gotoh, Y; Yamaguchi, T; Yatsuya, H; Ikeda, A; Okamura, T; Sakakibara, Y; Ina, T; Maeda, Y; Hirochi, M; Kako, H; Goto, Y; Isogai, S; Yamamoto, N; Kondo, M; Imaizumi, K

BMC PULMONARY MEDICINE 21 巻 ( 1 ) 頁： 181 - 181 2021年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMC Pulmonary Medicine

Background: Pneumothorax is one complication of transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath (EBUS-GS-TBB). We sought to clarify the risk factors for pneumothorax after EBUS-GS-TBB under fluoroscopic guidance. Methods: We retrospectively reviewed data from 916 patients who underwent EBUS-GS-TBB at Fujita Health University Hospital. We evaluated the following risk factors for pneumothorax after EBUS-GS-TBB: patient characteristics (sex, age, and pulmonary comorbidities); lesion data (location, size, existence of ground-glass opacities [GGOs], pleural involvement, computed tomography [CT] bronchus sign, visibility on fluoroscopy, and EBUS findings); final diagnosis; years of bronchoscopist experience; and guide sheath size. Univariate and multivariate logistic regression analyses were performed. Results: Among the 916 patients, 30 (3.28%) presented with pneumothorax. With a univariate analysis, factors that independently predisposed to pneumothorax included lesions containing GGOs, lesions in sagittal lung segments on fluoroscopy, lesions that were not visible on fluoroscopy, and infectious lesions. A univariate analysis also showed that lesions in the right upper lobe or left upper division, as well as malignant lesions, were less likely to lead to pneumothorax. Age, underlying pulmonary disease, CT bronchus sign, EBUS findings, bronchoscopist experience, and guide sheath size did not influence the incidence of pneumothorax. A multivariate analysis revealed that only lesions containing GGOs (odds ratio [OR] 6.47; 95% confidence interval [CI] 2.13–19.6, P = 0.001) and lesions in lung segments with a sagittal orientation on fluoroscopy (OR 2.47; 95% CI 1.09–5.58, P = 0.029) were significant risk factors for EBUS-GS-TBB-related pneumothorax. Conclusions: EBUS-GS-TBB of lesions containing GGOs or lesions located in sagittal lung segments on fluoroscopy correlate with a higher pneumothorax risk.

DOI： 10.1186/s12890-021-01551-1

Prevalence of and factors associated with dilated choroidal vessels beneath the retinal pigment epithelium among the Japanese 査読有り

Ito, Y; Ito, M; Iwase, T; Kataoka, K; Yamada, K; Yasuda, S; Ito, H; Takeuchi, J; Nakano, Y; Fujita, A; Horiguchi, E; Taki, Y; Yatsuya, H; Terasaki, H

SCIENTIFIC REPORTS 11 巻 ( 1 ) 頁： 11278 2021年5月

記述言語：英語出版者・発行元：Scientific Reports

Pachyvessels are pathologically dilated large choroidal vessels and are associated with the pathogenesis of several pachychoroid-related disorders, including central serous chorioretinopathy. We aimed to investigate the prevalence of and risk factors for pachyvessels in the Japanese population. We included 316 participants (aged ≥ 40 years) with normal right eyes. The presence of pachyvessels (vertical diameter > 300 µm, distance to the retinal pigment epithelium < 50 µm) was determined using 6 × 6 mm macular swept-source optical coherence tomography images, and associated risk factors were investigated. Subfoveal choroidal thickness was measured, and its associated risk factors investigated. The overall prevalence of pachychoroids was 9.5%. Regression analysis showed that a younger age, shorter axial length, male sex, and smoking were significantly associated with the presence of pachyvessels (p = 0.047; odds ratio [OR] 0.96 per year, p = 0.021; OR 0.61 per 1 mm, p = 0.012; OR 3.08 vs. female, and p = 0.011; OR 3.15 vs. non-smoker, respectively) and greater choroidal thickness (p < 0.001, p < 0.001, p < 0.003, and p < 0.017, respectively). The results were consistent with other research findings which showed that pachychoroid-related disorders such as central serous chorioretinopathy were associated with younger age, male sex, shorter axial length, and smoking. Smoking may be associated with choroidal circulatory disturbance in the Japanese population.

DOI： 10.1038/s41598-021-90493-z

Web of Science

Scopus

PubMed

Inherited Chromosomally Integrated Human Herpesvirus 6 Is a Risk Factor for Spontaneous Abortion 査読有り国際誌

Miura, H; Kawamura, Y; Ohye, T; Hattori, F; Kozawa, K; Ihira, M; Yatsuya, H; Nishizawa, H; Kurahashi, H; Yoshikawa, T

JOURNAL OF INFECTIOUS DISEASES 223 巻 ( 10 ) 頁： 1717 - 1723 2021年5月

Perceptions and behaviors related to noncommunicable diseases in Palau: a qualitative study 査読有り

Shimizu, H; Hirakawa, Y; Chiang, C; Ngiralmau, B; Tellei, J; Rehuher-Marugg, FK; Mita, T; Yatsuya, H; Aoyama, A

NAGOYA JOURNAL OF MEDICAL SCIENCE 83 巻 ( 2 ) 頁： 287 - 298 2021年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nagoya Journal of Medical Science

The increasing burden of noncommunicable diseases (NCDs) is a major public health concern in Palau. This study aims to identify social and psychological factors related to NCDs among Palauan people using a qualitative approach. We conducted eight key informant interviews and eight focus group discussions, which were audio-recorded, transcribed and translated into English. Ideas of the respondents were extracted and labeled, and the labels were analyzed using an inductive multistage approach referred to as qualitative content analysis. Three themes emerged: (1) home education, (2) traditional local community, and (3) modernization and westernization of lifestyle. Respondents believed that the influence of the family on lifestyle was significant, but that disciplining children at home had become difficult. They considered that the traditional lifestyle was mostly healthy, and were reluctant to abandon certain unhealthy customs, such as serving abundant food to guests as a sign of fraternity. They also thought that they overate because of their stressful modernized lifestyle. This is the first qualitative study to analyze perception and behavior of the Palauan people in relation to NCDs. We found that the increase in NCDs was related to two concurrent trends: preserving certain traditional customs unfavorable to good health, and abandoning time-consuming healthy traditional lifestyle to adopt a modernized one. We also found that Palauan people were not confident in their ability to prevent NCDs. Therefore, health promotion activities should be designed to empower people to make positive changes.

DOI： 10.18999/nagjms.83.2.287

Weight change during middle age and risk of stroke and coronary heart disease: The Japan Public Health Center?based Prospective Study 査読有り国際誌

Kisanuki, K; Muraki, I; Yamagishi, K; Kokubo, Y; Saito, I; Yatsuya, H; Sawada, N; Iso, H; Tsugane, S

ATHEROSCLEROSIS 322 巻頁： 67 - 73 2021年4月

Avoid clinical inertia: Importance of asking and advising patients with diabetes who smoke about quitting 査読有り

Yatsuya, H

JOURNAL OF DIABETES INVESTIGATION 12 巻 ( 3 ) 頁： 317 - 319 2021年3月

Factors Associated With Prediabetes and Diabetes Among Public Employees in Northern Ethiopia 査読有り国際共著国際誌

He, YP; Chiang, CF; Gebremariam, LW; Hirakawa, Y; Yatsuya, H; Aoyama, A

ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH 33 巻 ( 2-3 ) 頁： 242 - 250 2021年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Asia-Pacific Journal of Public Health

The increasing burden of diabetes mellitus is one of the major public health challenges in African countries, including Ethiopia. This is the first study aimed to identify factors associated with prediabetes and diabetes defined by both fasting blood glucose and glycated hemoglobin in Ethiopians. We analyzed data of a cross-sectional survey (1372 adults aged 25-64 years) conducted between October 2015 and February 2016; multinomial logistic regression models were applied. Abdominal obesity, total cholesterol, and non–high-density lipoprotein cholesterol were independently associated with prediabetes and diabetes in both sexes. Increased triglycerides and religious fasting practices were independently associated with prediabetes and diabetes only in men; hypertension was associated with prediabetes and diabetes only in women, while high-density lipoprotein cholesterol was not associated with prediabetes and diabetes in either sex. Sex differences in the association of triglycerides, hypertension, and dietary habit suggest that different approaches of lifestyle modification may be required for men and women.

DOI： 10.1177/1010539520974848

Determinants of alcohol consumption and marijuana use among young adults in the Republic of Palau 査読有り国際共著

Sata, M; Cui, RZ; Chiang, CF; Singeo, ST; Watson, BM; Yatsuya, H; Honjo, K; Mita, T; Temengil, EJ; Madraisau, S; Yamagishi, K; Aoyama, A; Iso, H

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE 26 巻 ( 1 ) 頁： 12 2021年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Environmental Health and Preventive Medicine

Background: This study aimed to describe the status of alcohol consumption and drug use among young adults as well as their determinants. Methods: We conducted a cross-sectional study of 356 young adults (aged 18 to 24 years) living in Palau in 2013. The prevalence of self-reported alcohol and marijuana usage were compared within and between sexes, age groups, ethnicities, and education levels. Results: The proportion of current drinking was higher in people aged 21–24 than in those aged 18–20 (73.2% vs. 60.9%, p = 0.09 in men and 48.3% vs. 30.0%, p = 0.02 in women), while that of marijuana use did not differ between the age groups. The proportions of current drinking and marijuana use were higher in Palauan than in other ethnicities (current drinking: 70.6% vs. 40.6%, p = 0.005 in men and 38.8% vs. 16.6%, p = 0.04 in women; lifetime marijuana use: 80.0% vs. 52.9%, p = 0.02 in men and 56.1% vs. 30.6%, p = 0.09 in women). The proportion of frequent (3 times or more) marijuana users was higher for the lower educated than for the higher educated (62.5% vs. 32.1%, p < 0.001 in men and 33.9% vs. 24.4%, p = 0.12 in women). Conclusions: Sex, age, ethnicity, and education were significant determinants of alcohol and marijuana use.

DOI： 10.1186/s12199-020-00928-8

その他リンク： http://link.springer.com/article/10.1186/s12199-020-00928-8/fulltext.html

Health of university students under job and financial insecurity during COVID-19 pandemic 招待有り

Yatsuya, H; Ishitake, T

JOURNAL OF OCCUPATIONAL HEALTH 63 巻 ( 1 ) 頁： e12223 2021年1月

Saif-Ur-Rahman, KM; Mamun, R; Li, YY; Matsunaga, M; Ota, A; Yatsuya, H

JOURNAL OF OCCUPATIONAL HEALTH 63 巻 ( 1 ) 頁： e12278 2021年1月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Occupational Health

Background: Diabetes is a major risk factor for cardiovascular diseases (CVD). This systematic review aims to explore the work-related factors among people with diabetes in developing CVD. Methods: Four electronic databases were searched on 1 February 2021 using a comprehensive search strategy without any time restriction. Two independent researchers screened the articles and extracted data. The risk of bias was assessed independently using the risk of bias assessment tool for non-randomized studies (RoBANS). A narrative synthesis was conducted considering the heterogeneity of the included articles. Results: A total of five articles incorporating 4 409 810 participants from three geographic regions were included that highlights the research gap. As per the included studies, Occupational drivers with diabetes were at a higher risk of CVD in comparison to the nondrivers, workers with diabetes having a long working hour were at a higher risk of CVD mortality, workers with a lower occupational status were at a higher risk of 10-years stroke risk, and occupational physical activity and occupational commuting lowered the risk of CVD deaths. Conclusions: This systematic review summarized the available evidence on work-related factors influencing the risk of CVD in people with diabetes. The findings should be interpreted cautiously pondering the limited evidence and imprecision. We identified only five articles related to the topic, and there were no studies from Japan. The scarcity of studies on work-related factors on the prognosis of diabetic patients implies the need for more research in this field. We recommend further exploration of the topic designing primary studies.

DOI： 10.1002/1348-9585.12278

その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/1348-9585.12278

一般的な代謝結果を予測するための人工ニューラルネットワークおよびロジスティック回帰の比較(Comparison of artificial neural network and logistic regression for predicting common metabolic outcomes)

He Yupeng, Chiang Chifa, Hirakawa Yoshihisa, Yatsuya Hiroshi

Journal of Epidemiology 31 巻 ( Suppl.1 ) 頁： 138 - 138 2021年1月

Apolipoprotein A2 Isoforms in Relation to the Risk of Myocardial Infarction: A Nested Case-Control Analysis in the JPHC Study 査読有り

Kihara, T; Yamagishi, K; Honda, K; Ikeda, A; Yatsuya, H; Saito, I; Kokubo, Y; Yamaji, T; Shimazu, T; Sawada, N; Iwasaki, M; Iso, H; Tsugane, S; Group, JS

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 28 巻 ( 5 ) 頁： 483 - 490 2021年

Estimation of 10-Year Risk of Death from Coronary Heart Disease, Stroke, and Cardiovascular Disease in a Pooled Analysis of Japanese Cohorts: EPOCH-JAPAN 査読有り

Li, YY; Yatsuya, H; Tanaka, S; Iso, H; Okayama, A; Tsuji, I; Sakata, K; Miyamoto, Y; Ueshima, H; Miura, K; Murakami, Y; Okamura, T

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 28 巻 ( 8 ) 頁： 816 - 825 2021年

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Atherosclerosis and Thrombosis

Aims: We aimed to develop and validate risk prediction models to estimate the absolute 10-year risk of death from coronary heart disease (CHD), stroke, and cardiovascular disease (CVD). Methods: We evaluated a total of 44,869 individuals aged 40-79 years from eight Japanese prospective cohorts to derive coefficients of risk equations using cohort-stratified Cox proportional hazard regression models. Discrimination (C-index) of the equation was examined in each cohort and summarised using random-effect metaanalyses. Calibration of the equation was assessed using Hosmer-Lemeshow chi-squared statistic. Results: Within a median follow-up of 12.7 years, we observed 765 deaths due to CVD (276 CHDs and 489 strokes). After backward selection, age, sex, current smoking, systolic blood pressure (SBP), proteinuria, prevalent diabetes mellitus, the ratio of total cholesterol to high-density lipoprotein cholesterol (TC/HDLC), interaction terms of age by SBP, and age by current smoking were retained as predictors for CHD. Sex was excluded in the stroke equation. We did not consider TC/HDLC as a risk factor for the stroke and CVD equations. The pooled C-indices for CHD, stroke, and CVD were 0.83, 0.80, and 0.81, respectively, and the corresponding p-values of the Hosmer-Lemeshow tests were 0.18, 0.003, and 0.25, respectively. Conclusions: Risk equations in the present study can adequately estimate the absolute 10-year risk of death from CHD, stroke, and CVD. Future work will evaluate the system as an education and risk communication tool for primary prevention of CHD and stroke.

DOI： 10.5551/jat.58958

Pelvic exenteration associated with future renal dysfunction 査読有り

Sando, M; Uehara, K; Li, YY; Alba, T; Ogura, A; Ebata, T; Kodera, Y; Yatsuya, H; Nagino, M

SURGERY TODAY 50 巻 ( 12 ) 頁： 1601 - 1609 2020年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Surgery Today

Purpose: This study aimed to clarify the long-term change in the renal function after pelvic exenteration (PE) and to evaluate the risk factors for any future dysfunction. Methods: This study comprised 40 patients. A greater than 25% decline in the estimated glomerular filtration rate (eGFR) at 3 years was defined as early renal function disorder (ERFD), possibly predicting future chronic kidney disease (CKD). Results: In the entire cohort, the median eGFR decreased by 23% at 3 years, and CKD developed in 50%. The patients were divided into the ERFD (n = 16) and non-ERFD (n = 24) groups. In the ERFD group, the eGFR significantly decreased by 28% during the first 1.5 years and continued to decline after that, resulting in 81.3% of patients reaching CKD, whereas it was 4% and 37.5%, respectively, in the non-ERFD group. In a growth model analysis, late urinary tract complications (UTC) and small bowel obstruction were shown to be risk factors for ERFD. Conclusion: Although PE was associated with a high incidence of future CKD, ERFD could predict it. Close observation of the eGFR decline over 1.5 years might be beneficial to identify ERFD patients. High-risk patients with late UTC and small bowel obstruction should, therefore, be observed carefully.

DOI： 10.1007/s00595-020-02036-0

Increased risk of occupational trichloroethylene hypersensitivity syndrome at exposure levels higher than 15 mg/L of urinary trichloroacetic acid, regardless of whether the patients had the <i>HLA-B*13:01</i> allele 査読有り国際共著国際誌

Wang, HL; Nakajima, T; Ito, Y; Naito, H; Zhao, N; Li, HL; Qiu, XX; Xia, LH; Chen, JB; Wu, QF; Li, LY; Huang, HL; Yanagiba, Y; Qu, HY; Yatsuya, H; Kamijima, M

ENVIRONMENTAL RESEARCH 191 巻頁： 109972 - 109972 2020年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Environmental Research

Occupational trichloroethylene (TCE) exposure can cause hypersensitivity syndrome (TCE-HS). The human leukocyte antigen (HLA)-B*13:01 is reportedly an important allele involved in TCE-HS onset. However, the threshold exposure level causing TCE-HS in relation to HLA-B*13:01 remains unknown. We conducted a case-control study comprising 37 TCE-HS patients and 97 age- and sex-matched TCE-tolerant controls from the Han Chinese population. Urine and blood of patients were collected on the first day of hospitalization, and those of controls were collected at the end of their shifts. Urinary trichloroacetic acid (TCA) was measured as an exposure marker, and end-of-shift levels in the patients were estimated using the biological half-life of 83.7 h. HLA-B genotype was identified using DNA from blood. Crude odds ratios (ORs) for TCE-HS in the groups with urinary TCA concentration >15 mg/L to ≤50 mg/L and of >50 mg/L were 21.9 [95% confidence interval (CI) 4.2–114.1] and 27.6 (6.1–125.8), respectively, when the group with urinary TCA ≤15 mg/L was used as a reference. The frequency of HLA-B*13:01, the most common allele in the patients, was 62.2% (23/37), which was significantly higher than 17.5% (17/97) in the TCE-tolerant controls, with a crude OR of 8.4 (3.1–22.6). The mutually-adjusted ORs for urinary TCA >15 to ≤50 mg/L, >50 mg/L, and for HLA-B*13:01 were 33.4 (4.1–270.8), 34.0 (5.3–217.1), and 11.0 (2.4–50.7), respectively. In conclusion, reduction of TCE exposure to ≤15 mg/L is required for TCE-HS prevention because urinary TCA concentration >15 mg/L showed increased risk of TCE-HS, regardless of whether the patients had the HLA-B*13:01 allele.

DOI： 10.1016/j.envres.2020.109972

Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study 査読有り国際共著

Roth G.A., Mensah G.A., Johnson C.O., Addolorato G., Ammirati E., Baddour L.M., Barengo N.C., Beaton A., Benjamin E.J., Benziger C.P., Bonny A., Brauer M., Brodmann M., Cahill T.J., Carapetis J.R., Catapano A.L., Chugh S., Cooper L.T., Coresh J., Criqui M.H., DeCleene N.K., Eagle K.A., Emmons-Bell S., Feigin V.L., Fernández-Sola J., Fowkes F.G.R., Gakidou E., Grundy S.M., He F.J., Howard G., Hu F., Inker L., Karthikeyan G., Kassebaum N.J., Koroshetz W.J., Lavie C., Lloyd-Jones D., Lu H.S., Mirijello A., Misganaw A.T., Mokdad A.H., Moran A.E., Muntner P., Narula J., Neal B., Ntsekhe M., Oliveira G.M.M., Otto C.M., Owolabi M.O., Pratt M., Rajagopalan S., Reitsma M.B., Ribeiro A.L.P., Rigotti N.A., Rodgers A., Sable C.A., Shakil S.S., Sliwa K., Stark B.A., Sundström J., Timpel P., Tleyjeh I.I., Valgimigli M., Vos T., Whelton P.K., Yacoub M., Zuhlke L.J., Abbasi-Kangevari M., Abdi A., Abedi A., Aboyans V., Abrha W.A., Abu-Gharbieh E., Abushouk A.I., Acharya D., Adair T., Adebayo O.M., Ademi Z., Advani S.M., Afshari K., Afshin A., Agarwal G., Agasthi P., Ahmad S., Ahmadi S., Ahmed M.B., Aji B., Akalu Y., Akande-Sholabi W., Aklilu A., Akunna C.J., Alahdab F., Al-Eyadhy A., Alhabib K.F., Alif S.M., Alipour V., Aljunid S.M., Alla F., Almasi-Hashiani A., Almustanyir S.

Journal of the American College of Cardiology 76 巻 ( 25 ) 頁： 2982 - 3021 2020年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of the American College of Cardiology

Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019. Prevalent cases of total CVD nearly doubled from 271 million (95% uncertainty interval [UI]: 257 to 285 million) in 1990 to 523 million (95% UI: 497 to 550 million) in 2019, and the number of CVD deaths steadily increased from 12.1 million (95% UI:11.4 to 12.6 million) in 1990, reaching 18.6 million (95% UI: 17.1 to 19.7 million) in 2019. The global trends for disability-adjusted life years (DALYs) and years of life lost also increased significantly, and years lived with disability doubled from 17.7 million (95% UI: 12.9 to 22.5 million) to 34.4 million (95% UI:24.9 to 43.6 million) over that period. The total number of DALYs due to IHD has risen steadily since 1990, reaching 182 million (95% UI: 170 to 194 million) DALYs, 9.14 million (95% UI: 8.40 to 9.74 million) deaths in the year 2019, and 197 million (95% UI: 178 to 220 million) prevalent cases of IHD in 2019. The total number of DALYs due to stroke has risen steadily since 1990, reaching 143 million (95% UI: 133 to 153 million) DALYs, 6.55 million (95% UI: 6.00 to 7.02 million) deaths in the year 2019, and 101 million (95% UI: 93.2 to 111 million) prevalent cases of stroke in 2019. Cardiovascular diseases remain the leading cause of disease burden in the world. CVD burden continues its decades-long rise for almost all countries outside high-income countries, and alarmingly, the age-standardized rate of CVD has begun to rise in some locations where it was previously declining in high-income countries. There is an urgent need to focus on implementing existing cost-effective policies and interventions if the world is to meet the targets for Sustainable Development Goal 3 and achieve a 30% reduction in premature mortality due to noncommunicable diseases.

DOI： 10.1016/j.jacc.2020.11.010

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