研究者詳細 - 八谷　寛

論文 - 八谷　寛

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Synergistic and Non-synergistic Associations for Cigarette Smoking and Non-tobacco Risk Factors for Cardiovascular Disease Incidence in the Atherosclerosis Risk In Communities (ARIC) Study 査読有り国際共著国際誌

Lubin, JH; Couper, D; Lutsey, PL; Yatsuya, H

NICOTINE & TOBACCO RESEARCH 19 巻 ( 7 ) 頁： 826 - 835 2017年7月

Matsunaga, M; Yatsuya, H; Iso, H; Yamashita, K; Li, YY; Yamagishi, K; Tanabe, N; Wada, Y; Wang, CC; Ota, A; Tamakoshi, K; Tamakoshi, A

ATHEROSCLEROSIS 261 巻頁： 124 - 130 2017年6月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Atherosclerosis

Background and aims Coronary heart disease (CHD) and stroke have common risk factors, but some of these differ in the magnitude or direction of associations between CHD and stroke. We assessed whether the impact of each risk factor differed between CHD and stroke mortality in Asians. Methods In total, 104 910 subjects aged 40–79 years without histories of cancer, CHD and stroke at baseline were followed between 1988 and 2009. Competing-risks analysis was used to test for differences in the associations of each risk factor with two endpoints (CHD and stroke). Population attributable fractions (PAFs) were also calculated for these endpoints to estimate the population impact of each risk factor. Results During a median 19.1-year follow-up, 1554 died from CHD and 3163 from stroke. The association of hypertension with CHD was similar to that with stroke in terms of the magnitude and direction (multivariable-adjusted hazard ratio for CHD: 1.63 vs. stroke: 1.73 in men and 1.70 vs. 1.66 in women). Conversely, the magnitude of these associations differed for smoking (CHD: 1.95 vs. stroke: 1.23 in men and 2.45 vs. 1.35 in women) and diabetes (1.49 vs. 1.09 in men and 2.08 vs. 1.39 in women). The highest PAF for CHD was caused by smoking in men and by hypertension in women; that for stroke was caused by hypertension in both sexes. Conclusions Hypertension associations and PAFs were consistent between CHD and stroke, but not for other risk factors. These findings may be useful to optimize public health intervention strategies.

DOI： 10.1016/j.atherosclerosis.2017.03.003

Descriptive Epidemiology of Hypertension and Its Association With Obesity: Based on the WHO STEPwise Approach to Surveillance in Palau 査読有り国際共著国際誌

Wang, CC; Chiang, CF; Yatsuya, H; Hilawe, EH; Ikerdeu, E; Honjo, K; Mita, T; Cui, RZ; Hirakawa, Y; Madraisau, S; Iso, H; Aoyama, A

ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH 29 巻 ( 4 ) 頁： 278 - 287 2017年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Asia-Pacific Journal of Public Health

The rise of noncommunicable diseases is a serious health burden for Palau. This study described the prevalence of hypertension, and assessed its association with obesity. Surveys following the WHO STEPwise approach to surveillance were conducted in 2529 adults. Multivariate prevalence ratios (PR) of hypertension for body mass index (BMI) categories were calculated by logistic regression models using conditional standardization procedure. Age- and sex-specified analyses were performed. Overall prevalence of obesity and hypertension were 40.4% and 46.8%, respectively. Prevalence of hypertension was positively associated with BMI. However, overweight men had as high prevalence of hypertension as the obese (multivariable-adjusted PR was 1.84 for overweight and 1.91 for obese compared with nonoverweight). The association between hypertension and BMI was similar across age groups. The prevalence of hypertension in women increased gradually with the increase of BMI whereas that in men reached a plateau already in the overweight.

DOI： 10.1177/1010539517704042

Disparity in metabolic risk factors of non-communicable diseases between Palauans and Filipinos living in Palau 査読有り国際共著国際誌

Osako, A; Chiang, CF; Ito, K; Yatsuya, H; Hilawe, EH; Ikerdeu, E; Honjo, K; Mita, T; Cui, RZ; Hirakawa, Y; Madraisau, S; Ngirmang, G; Iso, H; Aoyama, A

NAGOYA JOURNAL OF MEDICAL SCIENCE 79 巻 ( 2 ) 頁： 157 - 165 2017年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nagoya Journal of Medical Science

Non-communicable diseases have been recognized as a serious threat to public health in Palau. To tackle the problem, different strategies might be necessary for populations with different ethnic backgrounds. This study aims to find the differences in the prevalence of metabolic risk factors of non-communicable diseases between Palauans and Filipinos living in Palau, and examine possible determinants of the differences. We selected data of 2,032 participants, including native Palauans and Filipinos, from the Palau STEPS Survey 2011-2013 for this study. Logistic regression models were used to inspect the association of each metabolic risk factor with ethnicity by calculating odds ratios adjusted for potential confounding factors. Palauans had higher age-standardized prevalence of overweight or obesity (84% vs. 45%), hypertension (50% vs. 38%) and diabetes (19% vs. 13%) than Filipinos. However, after adjusting for BMI and various lifestyle related factors, there are no statistical significant differences in the prevalence of hypertension and diabetes between these two ethnic groups. Palauan men were less likely to have elevated total cholesterol, especially after adjusting for BMI (odds ratio=0.55, 95% confidence interval: 0.33-0.91), while Palauan women were more likely to have elevated triglycerides than their Filipino counterparts (odds ratio=1.45, 95% confidence interval: 1.02-2.06). Our findings suggested that Palauans' higher BMI distribution might be able to explain their higher prevalence of hypertension and partially explain their higher diabetes prevalence. Palauans were not consistently more likely to have all metabolic risk factors, namely dyslipidemia were less likely to be observed in Palauan men.

DOI： 10.18999/nagjms.79.2.157

Passive smoking and chronic obstructive pulmonary disease mortality: findings from the Japan collaborative cohort study 査読有り国際誌

Ukawa, S; Tamakoshi, A; Yatsuya, H; Yamagishi, K; Ando, M; Iso, H

INTERNATIONAL JOURNAL OF PUBLIC HEALTH 62 巻 ( 4 ) 頁： 489 - 494 2017年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Public Health

Objectives: To elucidate the association between passive smoking at home and chronic obstructive pulmonary disease (COPD) mortality via a large-scale nationwide cohort study in Japan. Methods: Never smokers (n = 34,604) aged 40–79 years at baseline (1988–1990; 4884 men, 29,720 women) were included in the analysis. Passive smoking at home was measured based on self-reported frequency of weekly exposure to passive smoking at home. An inverse probability of treatment-weighted competing risk model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for COPD mortality. Results: During a median follow-up of 16.4 years, 33 participants (10 men, 23 women) died of COPD. The HR for participants exposed to passive smoking at home ≤4 days per week or those who had almost daily exposure to passive smoking at home had a significantly increased risk of COPD mortality (HR 2.40, 95% CI 1.39–4.15, HR 2.88, 95% CI 1.68–4.93, respectively). Conclusions: The present findings suggest that avoiding passive smoking at home may be beneficial for preventing death due to COPD among never smokers.

DOI： 10.1007/s00038-016-0938-1

Increased airway hyperresponsiveness to adenosine in patients with aspirin intolerant asthma 査読有り国際誌

Isogai, S; Niwa, Y; Yatsuya, H; Hayashi, M; Yamamoto, N; Okamura, T; Minezawa, T; Goto, Y; Yamaguchi, T; Takeyama, T; Sakakibara, Y; Morikawa, S; Horiguchi, T; Gotoh, Y; Mieno, Y; Uozu, S; Nakanishi, T; Okazawa, M; Sakakibara, H; Imaizumi, K

ALLERGOLOGY INTERNATIONAL 66 巻 ( 2 ) 頁： 360 - 362 2017年4月

Long-term weight-change slope, weight fluctuation and risk of type 2 diabetes mellitus in middle-aged Japanese men and women: findings of Aichi Workers' Cohort Study 査読有り国際誌

Zhang, Y; Yatsuya, H; Li, Y; Chiang, C; Hirakawa, Y; Kawazoe, N; Tamakoshi, K; Toyoshima, H; Aoyama, A

NUTRITION & DIABETES 7 巻 ( 3 ) 頁： e252 2017年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nutrition and Diabetes

OBJECTIVE: This study aims to investigate the association of long-term weight-change slopes, weight fluctuation and the risk of type 2 diabetes mellitus (T2DM) in middle-aged Japanese men and women. METHODS: A total of 4234 participants of Aichi Workers' Cohort Study who were aged 35-66 years and free of diabetes in 2002 were followed through 2014. Past body weights at the ages of 20, 25, 30, 40 years, and 5 years before baseline as well as measured body weight at baseline were regressed on the ages. Slope and root-mean-square-error of the regression line were obtained and used to represent the weight changes and the weight fluctuation, respectively. The associations of the weight-change slopes and the weight fluctuation with incident T2DM were estimated by Cox proportional hazards models. RESULTS: During the median follow-up of 12.2 years, 400 incident cases of T2DM were documented. After adjustment for baseline overweight and other lifestyle covariates, the weight-change slopes were significantly associated with higher incidence of T2DM (hazard ratio (HR): 1.80, 95% confident interval (CI): 1.17-2.77 for men; and HR: 2.78, 95% CI: 1.07-7.23 for women), while the weight fluctuation was not (HR: 1.08, 95% CI: 1.00-1.18 for men and HR: 1.02, 95% CI: 0.84-1.25 for women). CONCLUSIONS: Regardless of the presence of overweight, the long-term weight-change slopes were significantly associated with the increased risk of T2DM; however, the weight fluctuation was not associated with the risk of T2DM in middle-aged Japanese men and women.

DOI： 10.1038/nutd.2017.5

Daily Walking Time and Pneumonia Mortality Among Elderly With/Without Medical History of Myocardial Infarction or Stroke 査読有り

Ukawa Shigekazu, Zhao Wenjing, Yatsuya Hiroshi, Yamagishi Kazumasa, Iso Hiroyasu, Tamakoshi Akiko

CIRCULATION 135 巻 2017年3月

A Point-based Prediction Model for Predicting 10-year Risk of Developing Type 2 Diabetes Mellitus in Japanese Men: Aichi Workers' Cohort Study 査読有り

Li, YY; Yatsuya, H; Hirakawa, Y; Ota, A; Matsunaga, M; Haregot, HE; Chiang, CF; Zhang, Y; Tamakoshi, K; Toyoshima, H; Aoyama, A

CIRCULATION 135 巻 2017年3月

Daily Walking Time and Pneumonia Mortality Among Elderly With/Without Medical History of Myocardial Infarction or Stroke 査読有り

Shigekazu Ukawa, Wenjing Zhao, Hiroshi Yatsuya, Kazumasa Yamagishi, Hiroyasu Iso, Akiko Tamakoshi

CIRCULATION 135 巻 2017年3月

No modifying effect of education level on the association between lifestyle behaviors and cardiovascular mortality: the Japan Collaborative Cohort Study 査読有り国際誌

Eguchi, E; Iso, H; Honjo, K; Yatsuya, H; Tamakoshi, A

SCIENTIFIC REPORTS 7 巻頁： 39820 2017年1月

Population profile and residential environment of an urban poor community in Dhaka, Bangladesh 査読有り国際共著国際誌

Khalequzzaman, M; Chiang, CF; Hoque, BA; Choudhury, SR; Nizam, S; Yatsuya, H; Matsuyama, A; Hirakawa, Y; Islam, SS; Iso, H; Aoyama, A

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE 22 巻 ( 1 ) 頁： 1 2017年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Environmental Health and Preventive Medicine

Objectives: A population survey was conducted in an urban shantytown in Bangladesh, as a baseline study of future epidemiological studies. This paper aims to describe the findings of the study, including the population profile and residential environment of the urban poor. Methods: We conducted a complete count household survey in an urban poor community in Dhaka. Using a brief structured questionnaire in Bengali language, trained interviewers visited each household and asked questions such as: duration of residence; ownership of house, toilet and kitchen; water supply; number of family members; age, sex, education, occupation, tobacco use, and history of diseases of each family member. Results: We found that there were 8604 households and 34,170 people in the community. Average number of household members was 4.0. Most people had access to safe water, but only 16% lived in the house with a toilet. Based on the proxy indicators of household wealth levels, we identified that about 39% were relatively well-off, while the rest were very poor. Tobacco use was prevalent in men regardless of age and in women aged over 35 years. Prevalence of self-reported hypertension and diabetes was slightly higher in women than in men, although over 70% of the respondents didn't know if they had such diseases. Incidences of diarrhea in the last one month were relatively low. Conclusions: The study showed population profile and sanitation environment in an urban poor community by a complete count survey. We expect the study to serve as a baseline for future epidemiological studies.

DOI： 10.1186/s12199-017-0610-2

Risk Factor of Cardiovascular Disease Among Older Individuals 査読有り国際誌

Yatsuya, H; Matsunaga, M; Li, YY; Ota, A

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 24 巻 ( 3 ) 頁： 258 - 261 2017年

Age-specific impact of diabetes mellitus on the risk of cardiovascular mortality: An overview from the evidence for Cardiovascular Prevention from Observational Cohorts in the Japan Research Group (EPOCH-JAPAN) 査読有り

Yoichiro Hirakawa, the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Research Group (EPOCH-JAPAN), Toshiharu Ninomiya, Yutaka Kiyohara, Yoshitaka Murakami, Shigeyuki Saitoh, Hideaki Nakagawa, Akira Okayama, Akiko Tamakoshi, Kiyomi Sakata, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura, Yutaka Imai, Takayoshi Ohkubo, Fujiko Irie, Hiroyasu Iso, Akihiko Kitamura, Takeo Nakayama, Toshimi Sairenchi, Ichiro Tsuji, Michiko Yamada, Masahiko Kiyama, Yoshihiro Miyamoto, Shizukiyo Ishikawa, Hiroshi Yatsuya

Journal of Epidemiology 27 巻 ( 3 ) 頁： 123 - 129 2017年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japan Epidemiology Association

Background: Diabetes mellitus is a strong risk factor for cardiovascular disease. However, the age-specific association of diabetes with cardiovascular risk, especially in the elderly, remains unclear in non-Western populations. Methods: A pooled analysis was conducted using 8 cohort studies (mean follow-up period, 10.3 years) in Japan, combining the data from 38,854 individual participants without history of cardiovascular disease. In all, 1867 of the participants had diabetes, defined based on the 1998 World Health Organization criteria. The association between diabetes and the risk of death from cardiovascular disease, coronary heart disease (CHD), and stroke was estimated using a stratified Cox model, accounting for variability of baseline hazard functions among cohorts. Results: During the follow-up, 1376 subjects died of cardiovascular disease (including 268 of coronary heart disease and 621 of stroke). Diabetes was associated with an increased risk of cardiovascular death after multivariable adjustment (hazard ratio [HR] 1.62
95% confidence interval [CI], 1.35-1.94). Similarly, diabetes was a risk factor for CHD (HR 2.13
95% CI, 1.47-3.09) and stroke (HR 1.40
95% CI, 1.05-1.85). In the age-stratified analysis of the risk of cardiovascular death, the relative effects of diabetes were consistent across age groups (p for heterogeneity = 0.18), whereas the excess absolute risks of diabetes were greater in participants in their 70s and 80s than in younger subjects. Conclusions: The management of diabetes is important to reduce the risk of death from cardiovascular disease, not only in midlife but also in late life, in the Japanese population.

DOI： 10.1016/j.je.2016.04.001

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Dietary intake of saturated fatty acids and mortality from cardiovascular disease in Japanese: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) Study 査読有り

Yamagishi K, Iso H, Yatsuya H, Tanabe N, Date C, Kikuchi S, Yamamoto A, Inaba Y, Tamakoshi A; JACC Study Group.

Am J Clin Nutr 92 巻 ( 4 ) 頁： 759-765 2010年10月

Sex-Specific HDL Cholesterol Changes With Weight Loss and Their Association With Anthropometric Variables: The LIFE Study 査読有り国際共著

Yatsuya H, Jeffery RW, Erickson DJ, Welsh EM, Flood AP, Jaeb MA, Laqua PS, Mitchell NR, Langer SL, Levy RL

Obesity (Silver Spring) Epub 巻 2010年9月

Associations of obesity measures with subtypes of ischemic stroke in the ARIC Study. 査読有り国際共著

Yatsuya H, Yamagishi K, North KE, Brancati FL, Stevens J, Folsom AR; ARIC Study Investigators.

J Epidemiol 20 巻 ( 5 ) 頁： 347-354 2010年9月

Risk of incident cardiovascular disease among users of smokeless tobacco in the Atherosclerosis Risk in Communities (ARIC) study. 査読有り国際共著

Yatsuya H, Folsom AR; ARIC Investigators.

Am J Epidemiol 172 巻 ( 5 ) 頁： 600-605 2010年9月

Body mass index and risk of stroke and myocardial infarction in a relatively lean population: meta-analysis of 16 Japanese cohorts using individual data. 査読有り

Yatsuya H, Toyoshima H, Yamagishi K, Tamakoshi K, Taguri M, Harada A, Ohashi Y, Kita Y, Naito Y, Yamada M, Tanabe N, Iso H, Ueshima H; Japan Arteriosclerosis Longitudinal Study (JALS) group.

Circ Cardiovasc Qual Outcomes. 3 巻 ( 5 ) 頁： 498-505 2010年9月

Maintenance-tailored therapy vs. standard behavior therapy for 30-month maintenance of weight loss. 査読有り国際共著

Levy RL, Jeffery RW, Langer SL, Graham DJ, Welsh EM, Flood AP, Jaeb MA, Laqua PS, Finch EA, Hotop AM, Yatsuya H.

Prev Med Epub 巻 2010年9月

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