研究者詳細 - 八谷　寛

Body mass index and activities of daily living impairment: systematic review and meta-analysis. 査読有り国際共著 Open Access

Mamun MR, Nuamah HG, Hong YJ, Song Z, Akter T, Yoshida Y, Nakano Y, Saif-Ur-Rahman KM, Yatsuya H, Otsuka R

European journal of clinical nutrition 2026年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：European Journal of Clinical Nutrition

Both underweight and obesity have been linked to increased risk of disability, yet evidence on the relationship between body mass index (BMI) and activities of daily living (ADL) impairment remains inconsistent. To examine these associations in adults, we conducted this systematic review and meta-analysis following the standard methods and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Six databases were searched from inception to August 12, 2024. The protocol is registered in the PROSPERO (CRD42022357046). Abstracts and full-text articles describing associations between BMI and ADL impairment were screened using Rayyan software. Study quality was assessed using the RoBANS tool. A random-effects model meta-analysis was performed using metaanalysisonline, a web-based meta-analytic platform, with BMI categories of <18.5 (underweight), 25–29.9 (overweight), and ≥30 (obese) as exposures, and 18.5–24.9 (normal) as the reference. Of the initial 25,212 articles identified, 132 studies met the inclusion criteria. The meta-analysis showed positive association in both longitudinal studies [odds ratio (OR) 1.77, 95% confidence interval (CI): 1.54–2.03] and cross-sectional studies (OR: 1.56, 95% CI: 1.38–1.76). Overweight individuals exhibited a moderate increase in ADL risk in longitudinal studies (OR: 1.19, 95% CI: 1.09–1.30), but not in cross-sectional studies (OR: 1.06, 95% CI: 0.95–1.18). Both longitudinal and cross-sectional studies revealed a positive association between underweight participants and ADL impairment (OR: 1.20, 95% CI: 1.02–1.42; OR: 1.46, 95% CI: 1.24–1.72, respectively). Individuals with higher BMI, as well as those who are underweight, are at increased risk of ADL limitations.

DOI： 10.1038/s41430-026-01707-4

Multidimensional fatigue profiles, workplace factors, and work-related outcomes in long-term cancer survivors: findings from the Aichi workers' cohort study 査読有り

Impact of normoglycaemia and prediabetes definitions on the estimated benefits of regression from prediabetes to normoglycaemia for type 2 diabetes risk. Reply to Choi W [Letter] 査読有り国際共著

Davoodian, N; Lotfaliany, M; Huxley, RR; Lee, CMY; Pasco, JA; Adams, RJ; Azizi, F; Bertoni, AG; Colagiuri, S; Gregg, EW; Gill, TK; Hadaegh, F; Khalili, D; Magliano, DJ; Mongraw-Chaffin, M; Mishra, GD; Shaw, JE; Sakurai, M; Yatsuya, H; Mohebbi, M

DIABETOLOGIA 69 巻 ( 2 ) 頁： 531 - 532 2026年2月

Association of Work-Related Stressors, Support and Satisfaction with Cardiovascular Disease Incidence Among Japanese Civil Servants: A Prospective Cohort Study. 査読有り Open Access

Song Z, Takada M, Wang S, Nishio N, Shi X, Kobayashi M, Matsunaga M, Hosaka Y, Ota A, Otsuka R, Tamakoshi K, Yatsuya H

Journal of occupational health 2026年1月

Matsunaga, M; He, YP; Song, Z; Takada, M; Yatsuya, H; Ota, A

JOURNAL OF CANCER SURVIVORSHIP 2026年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Cancer Survivorship

Purpose: This study aimed to (1) identify distinct multidimensional fatigue profiles among employed cancer survivors, (2) examine associations between workplace factors and these profiles, and (3) assess how these profiles are associated with occupational outcomes. Methods: Seventy-two employed cancer survivors aged 27 to 64 years (median 9.4 years since diagnosis) from a local government in Japan completed questionnaires in 2023 assessing cancer-related fatigue (Cancer Fatigue Scale), workplace factors (job demands, job control, workplace support), and occupational outcomes (work engagement, presenteeism, cognitive function at work, and quality of life). Fatigue profiles were identified using hierarchical cluster analysis. Associations between workplace factors and profiles were examined using multinomial logistic regression. Occupational outcome differences among profiles were examined using linear regression. Results: Three profiles were identified: Low Global Fatigue (n = 12), Dominant Mental Fatigue (n = 36), and High Global Fatigue (n = 24). Workplace support—particularly supervisor understanding, colleague understanding, and schedule flexibility—was associated with approximately 75% lower odds of belonging to the High Global Fatigue group. Job demands and job control showed no associations. The High Global Fatigue group reported lower work engagement, higher presenteeism, reduced cognitive function at work, and poorer quality of life compared to the other groups. Conclusions: Three multidimensional fatigue profiles were identified among employed cancer survivors. Workplace support factors were more strongly associated with fatigue profiles than job characteristics. These profiles were associated with occupational outcomes. Implication for Cancer Survivors: These distinct fatigue profiles can guide personalized workplace interventions to optimize support for employed cancer survivors.

DOI： 10.1007/s11764-026-01975-w

The association between chronotype and metabolic syndrome in middle-aged Japanese civil servants: A longitudinal study from Aichi Workers' Cohort 査読有り

Psychological distress and mental health service use trends in Japan (2013-2022): Focusing on the change before and after the COVID-19 pandemic 査読有り Open Access

Sasaki, N; Takae, A; Asaoka, H; Kuroda, N; Yatsuya, H; Nishio, N; Tabuchi, T; Nishi, D

JOURNAL OF AFFECTIVE DISORDERS 393 巻 ( Pt A ) 頁： 120398 2026年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Affective Disorders

This study investigated trends in psychological distress and mental health service use in Japan before and after the COVID-19 pandemic using nationally representative data from the Comprehensive Survey of Living Conditions (2013–2022). Psychological distress was assessed using the Japanese version of the Kessler 6 Scale, with scores of 5–12 indicating moderate distress and scores of ≥13 indicating high distress. Mental health service use was defined as regular visits to hospitals or clinics for depression or other psychological disorders. Analysis of data from 1,765,102 participants revealed that while the prevalence of moderate distress decreased from 24.9 % in 2019 to 21.8 % in 2022, the prevalence of high distress increased from 4.7 % to 5.0 % over the same period. Notably, increases in high distress were most prominent among aged 35–49 population. Cross-sectionally, women aged 26–34 showed highest prevalence of high distress (7.6 %). Additionally, mental health service use rose markedly, especially among young adults with high distress, with women consistently reporting higher distress and service utilization than men. These findings suggest a polarization in psychological distress in Japan, with a decline in moderate symptoms concurrent with a rise in severe distress, highlighting emerging gaps in mental health care. The results underscore the need for targeted interventions and the expansion of accessible, diverse mental health services to address unmet needs, particularly among vulnerable subgroups including young women and middle-aged population.

DOI： 10.1016/j.jad.2025.120398

Regression from prediabetes to normoglycaemia and the role of cardiometabolic risk factors on the subsequent risk of developing type 2 diabetes 査読有り国際共著 Open Access

DIABETOLOGIA 69 巻 ( 1 ) 頁： 69 - 80 2026年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Diabetologia

Aims/hypothesis: We aimed to investigate the association between reversion to normoglycaemia among individuals with prediabetes (fasting plasma glucose 5.6–6.9 mmol/l in the absence of other criteria for type 2 diabetes) and the subsequent risk of type 2 diabetes, and to examine whether concurrent favourable cardiometabolic risk factor profiles modify this association. Methods: We used individual-level data from prospective cohorts in the USA, Australia and Asia. Participants with prediabetes at baseline, with at least two follow-ups (n=8191) at median intervals of 2.9 years (IQR 2.3–9.0) and 3.1 years (IQR 2.6–3.6), were classified into restoration of normoglycaemia and persistent prediabetes groups based on the glucose status at the first follow-up (normoglycaemia or prediabetes). Type 2 diabetes occurrence was assessed at subsequent follow-ups. Hierarchical mixed-effects proportional hazards Weibull models estimated type 2 diabetes risk, adjusting for age, sex and cardiometabolic risk factors. A subgroup analysis evaluated the combined association of normoglycaemia restoration and normal cardiometabolic risk factor levels on subsequent type 2 diabetes risk. Results: In individuals with prediabetes, normoglycaemia restoration compared with persistent prediabetes was associated with a 51% lower risk of developing type 2 diabetes. Even lower risks were observed among individuals with concurrent favourable cardiometabolic profiles, including non-smokers (HR 0.20, 95% CI 0.10, 0.31), and those with normal BMI (0.16, 95% CI 0.06, 0.27), waist circumference (0.22, 95% CI 0.12, 0.33), waist-to-height ratio (0.15, 95% CI 0.03, 0.26), WHR (0.17, 95% CI 0.05, 0.28), and systolic (0.20, 95% CI 0.11, 0.30) and diastolic (0.25, 95% CI 0.12, 0.38) blood pressure, triacylglycerol (0.24, 95% CI 0.13, 0.35) and HDL-cholesterol levels (0.21, 95% CI 0.13, 0.29). Weight loss combined with normoglycaemia restoration was also associated with lower type 2 diabetes risk (0.18, 95% CI 0.07, 0.30) compared with weight gain and persistent prediabetes. Conclusions/interpretation: Our results suggest that prioritising normoglycaemia restoration during the prediabetes stage in clinical guidelines may contribute to reducing the risk of type 2 diabetes, particularly when accompanied by favourable cardiometabolic health profiles.

DOI： 10.1007/s00125-025-06555-8

Association of Adipose Tissue Insulin Resistance with Risk of Diabetes Incidents in Middleaged Japanese Workers according to BMI states: 17 years of Follow-up of Aichi Worker's Cohort study 査読有り Open Access

Akter, T; Song, Z; Takada, M; Hamrah, MH; Wang, S; Endale, BT; Paththamesthrige, SEP; Khine, MT; Matsunaga, M; Ota, A; Tamakoshi, K; Yatsuya, H

JOURNAL OF EPIDEMIOLOGY 36 巻 ( 1 ) 頁： 44 - 50 2026年1月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: Insulin resistance in adipocytes, manifested as high basal circulating free fatty acid (FFA) is thought to contribute to the development of type 2 diabetes mellitus (T2DM). However, the association between adipocyte insulin resistance (Adipo-IR) index and T2DM has rarely been explored in prospective studies. We examined this association in a middle-aged Japanese workers’ cohort. Since the association may differ according to the degree of overall adiposity, the analysis was stratified by the presence of overweight/obesity defined with body mass index (BMI). Methods: A total of 3,257 subjects (men 2501, women 756) aged 35–66 years were followed-up for up to 17 years. T2DM incidence was defined as fasting blood glucose level ≥126 mg/dL, glycated hemoglobin level ≥6.5%, or self-reported initiation of glucose-lowering medications. Adipo-IR was calculated as the product of FFA (mmol/L) and insulin (pmol/L) obtained from baseline fasting blood samples and divided into sex- and BMI category (<25 or ≥25 kg/m2)-specific tertiles. Cox-proportional hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for age, BMI, smoking status, physical activity, drinking habit, and family history of diabetes. Results: During a median of 14.6 years of follow-up, 365 developed T2DM. Compared with the lowest tertile, T2DM risk was significantly increased among the highest tertile category in overweight/obese men (HR 2.94; 95% CI, 1.76–4.90) and women (HR 4.24; 95% CI, 1.08–16.61). Conclusion: Adipo-IR was positively associated with T2DM risk in overweight/obese men and women.

DOI： 10.2188/jea.JE20250025

Endale, BT; Song, Z; Takada, M; Paththamesthrige, SEP; Matsunaga, M; Kitajima, T; Ota, A; Tamakoshi, K; Yatsuya, H

CHRONOBIOLOGY INTERNATIONAL 頁： 1 - 12 2025年12月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Chronobiology International

Chronotype, which reflects an individual’s preference for activity and sleep timing, has been associated with various chronic conditions, particularly the evening chronotype. Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that collectively increase the risk of developing type 2 diabetes mellitus and cardiovascular diseases. Previous studies on chronotype and MetS have been inconsistent, and none has explored the longitudinal association between MetS and its components. Therefore, this study investigated these associations in middle-aged Japanese civil servants. We analyzed 2231 non-rotating, non-night shift workers (aged 29–69, 71.6% male) from the Aichi Workers’ Cohort Study who participated in surveys in 2018 (baseline) and 2022 and were free of MetS at baseline. Participants were classified into morning, evening, or intermediate chronotypes using the shortened Morningness–Eveningness Questionnaire. MetS was defined according to the harmonized criteria for Japanese, based on waist circumference (≥85 cm for men and ≥90 cm for women), triglycerides, HDL cholesterol, blood pressure, and blood sugar levels. Over 4 y, 232 participants (10.4%) developed MetS, with a cumulative incidence rate of 9.9% in morning, 17.6% in evening, and 9.5% in intermediate types. Logistic regression analysis adjusted for sex, age, educational background, occupation, leisure-time physical activity, alcohol intake, sleep duration, smoking status, snoring, night-time awakening, sleep medication use, working hours, breakfast eating habit, and medication use for diabetes, hypertension, and dislipdemia, revealed that the evening type individuals had a significantly higher risk of MetS (OR: 2.30, 95% CI: 1.48–3.57) compared to intermediate types. In conclusion, evening chronotype was independently associated with a higher risk of developing MetS in middle-aged Japanese civil servants.

DOI： 10.1080/07420528.2025.2606278

Association between occupational stress responses and cardiovascular disease incidence in middle-aged Japanese: findings from the Aichi workers' cohort study 査読有り

Song, Z; Takada, M; Hong, YJ; Endale, BT; Nishio, N; Horikoshi, M; Khine, MT; Matsunaga, M; He, YP; Ota, A; Otsuka, R; Tamakoshi, K; Yatsuya, H

INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH 99 巻 ( 1 ) 頁： 3 2025年12月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Archives of Occupational and Environmental Health

Objectives: This study aimed to investigate the association between occupational stress responses indicated by fatigue and nonspecific physical complaints and the incidence of subsequent cardiovascular disease (CVD) in middle-aged Japanese workers. Methods: A cohort of 4,820 Japanese workers (3876 men and 944 women) aged 35–65 years was followed up from 2007 to March 2022 for CVD incidence. Fatigue and nonspecific physical complaints were evaluated using the 57-item Brief Job Stress Questionnaire, and each was categorized into two groups based on the presence or absence. Hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) for stress responses to CVD were estimated using a multivariable Cox proportional hazard model adjusted for age, sex, smoking status, alcohol consumption, regular exercise, sleep duration, working hours, body mass index, systolic blood pressure, total cholesterol, and histories of hypertension, hyperlipidemia, and diabetes, night shift and job type. Results: During the median follow-up of 13.7 years, 116 patients with CVD were identified. The presence of fatigue was independently associated with CVD incidence (HR: 2.28, 95% CI: 1.05–4.94). Similarly, the presence of nonspecific physical complaints was significantly associated with CVD incidence (HR: 2.54, 95% CI: 1.43–4.52). The sex-stratified analysis showed consistent results in men but not in women. Conclusions: These findings suggest that fatigue and nonspecific physical complaints may serve as early indicators of CVD risk among middle-aged Japanese male workers. Incorporating routine assessment of these stress responses into workplace health screening could facilitate targeted prevention strategies.

DOI： 10.1007/s00420-025-02189-w

Prevalence, severity, and risk factors of cancer-related fatigue among working cancer survivors: a systematic review and meta-analysis 査読有り

Association between eveningness and low back pain among public servants in Japan: a cross-sectional analysis of the Aichi Workers' Cohort Study 査読有り Open Access

Matsunaga, M; Okegawa, R; Fujita, N; Kitajima, T; Yatsuya, H; Ota, A

EUROPEAN SPINE JOURNAL 34 巻 ( 12 ) 頁： 5424 - 5430 2025年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：European Spine Journal

Purpose: Low back pain (LBP) is a common occupational health problem. Chronotype, an individual’s preferred timing of activity and sleep, has been linked to pain perception. Previous studies have found a potential association between chronotype and LBP, although the findings were limited by small sample sizes and restricted population types. We investigated the association between evening chronotype (eveningness) and LBP in a cohort comprising public servants of various ages. Methods: We conducted a cross-sectional analysis of 4728 full-time public servants in Japan. LBP was assessed using a self-reported question. Individuals’ chronotypes were determined using the reduced Morningness–Eveningness Questionnaire. The association between chronotype and LBP was analyzed using the chi-squared test and multiple logistic regression models adjusted for age, sex, occupation, overtime work, use of the internet/email, body mass index, smoking status, exercise habits, sedentary behavior, sleep duration, sleep medication use, and depressive symptoms. Results: In total, 30% of the subjects reported LBP. The most common chronotype was intermediate type (51%), followed by morningness (38%) and eveningness (11%). A significant association between eveningness and LBP was observed. After adjusting for potential confounders, individuals with eveningness had a higher prevalence of LBP than those with morningness (36.2% vs. 28.7%; odds ratio: 1.46; 95% confidence interval: 1.16–1.83). Conclusion: Eveningness was statistically associated with LBP in a cohort of public servants. The present findings would strengthen the association’s generalizability to more varied populations.

DOI： 10.1007/s00586-025-09048-9

新世代の認知行動療法（ACTやマインドフルネスなど）の産業保健での展開 Open Access

成定明彦, 髙﨑正子, 水口要平, 八谷寛

産業ストレス研究 32 巻 ( 4 ) 頁： 347 - 352 2025年11月

Analysis of the changes in health-related quality of life and employment status after surgery in patients with lung cancer: a single-center longitudinal study 査読有り Open Access

Kadomatsu, Y; Oga, T; Ota, A; Yatsuya, H; Kawasumi, Y; Ueno, H; Kato, T; Nakamura, S; Mizuno, T; Chen-Yoshikawa, TF

GENERAL THORACIC AND CARDIOVASCULAR SURGERY 73 巻 ( 11 ) 頁： 819 - 828 2025年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：General Thoracic and Cardiovascular Surgery

Objective: This study analyzed the changes in health-related quality of life (HRQOL) and employment status of patients undergoing lung cancer surgery in Japan. Methods: This was a single-center, prospective study on patients who underwent lung anatomical resection. The eligible patients completed self-reported HRQOL and employment surveys at baseline and 6 and 12 months postoperatively. HRQOL was assessed using questionnaires including the European Organization for Research and Treatment of Cancer Core Quality of Life questionnaire (EORTC QLQ-C30) and EORTC QLQ and Lung Cancer module and additional social engagement and work-related stress evaluation tools. Results: In total, 93 patients completed the baseline survey, and 80 provided survey data at 6 months postoperatively. The HRQOL scores of several factors significantly declined immediately after the surgery and then gradually improved. The EORTC global health score, which represents overall health status, returned to baseline levels at 12 months postoperatively. However, symptoms such as fatigue, dyspnea, and coughing did not return to baseline levels at 12 months postoperatively. Approximately 68% of the patients who were employed preoperatively continued to work at 12 months postoperatively. Conclusions: Lung cancer surgery significantly affected the HRQOL and employment status of the patients within the first 6 months after surgery. For patients who decide to return to work before full recovery of QOL, we consider the need for enhanced support to assist them as they can reintegrate into work and activities of daily living.

DOI： 10.1007/s11748-025-02144-z

その他リンク： https://link.springer.com/article/10.1007/s11748-025-02144-z/fulltext.html

Relationship between abdominal visceral adipose tissue and cardiovascular events in patients with acute coronary syndrome 査読有り Open Access

Ueyama, C; Horibe, H; Maekawa, Y; Hiramatsu, S; Yamase, Y; Funabiki, J; Takemoto, Y; Shigeta, T; Hibino, T; Kondo, T; Yatsuya, H; Ishii, H; Murohara, T

HEART AND VESSELS 40 巻 ( 11 ) 頁： 961 - 972 2025年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Heart and Vessels

Abdominal visceral adipose tissue (AVAT) is associated with the incidence of cardiovascular events (CVEs). We retrospectively evaluated the association between AVAT and the incidence of CVEs in 602 patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI). Patients were divided into four groups according to the quartiles of AVAT areas using computed tomography. The incidence of CVEs (cardiovascular death, ACS recurrence and stroke) during the follow-up period (median 49.5 months) was evaluated. Cox analysis adjusting for cardiovascular risk factors revealed that the AVAT quartile classification exhibited a significant association with the incidence of CVEs. The risk in quartile 3 (moderate AVAT areas, ≥ 106.0 to < 142.6 cm2) was significantly lower than in quartiles 1 (low AVAT areas, < 71.0cm2; P < 0.01; hazard ratio [HR], 5.06), 2 (mild AVAT areas, ≥ 71.0 to < 106.0 cm2; P < 0.01; HR, 4.25) and 4 (severe AVAT areas, ≥ 142.6 cm2; P < 0.01; HR, 4.52). Polynomial analyses revealed that quadratic model was the most appropriate to illustrate the relationship between AVAT area and the hazard ratios for CVEs (corrected Akaike's information criterion, 49.2; R2, 0.47). The AVAT area and the incidence of CVEs exhibited a U-shaped relationship in patients with ACS undergoing PCI independent of conventional cardiovascular risk factors. The risk of CVEs was the lowest in patients with moderate AVAT areas. Evaluating AVAT may provide additional information for the assessment of long-term prognosis in patients with ACS.

DOI： 10.1007/s00380-025-02557-z

Otsuka, R; Zhang, S; Nishita, Y; Kubota, S; Tange, C; Shimokata, H; Yatsuya, H

ARCHIVES OF GERONTOLOGY AND GERIATRICS 137 巻頁： 105943 2025年10月

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Archives of Gerontology and Geriatrics

Objective: To quantify annual changes and develop population-normalized aging curves for height, body weight, and grip strength according to specific birth cohorts. Methods: This longitudinal study analyzed data from the National Institute for Longevity Sciences – Longitudinal Study of Aging, following 1901 community-dwelling adults aged 40−79 years for up to 12 years. Annual changes in height, body weight, body mass index (BMI), body fat percentage, skeletal muscle mass, and grip strength were assessed by sex using linear mixed-effects models. Birth cohort-specific reference values according to sex were developed using participants who participated in at least one wave between 1997 and 2022 (n = 1990) with generalized additive mixed models. Results: Significant negative follow-up years × age interactions were observed for height, body weight, BMI, skeletal muscle mass, and grip strength in men (all p-values < 0.001) and for height, body weight, BMI, body fat percentage, and skeletal muscle mass in women (all p-values < 0.01). Grip strength began declining preceding any significant change in other indicators. For height and grip strength, birth cohort-specific reference values for age-related changes showed a gradual decline with age in both sexes, with more recent birth cohorts being consistently taller but having weaker grip strength than earlier cohorts. Men experienced slight weight increases until ages 60−70 years, followed by a decline. Women maintained a stable weight until age 60 years before declining. Conclusions: These reference values provide evidence-based tools for detecting age-related changes in body composition and function among relatively healthy participants and guiding preventive interventions in clinical and community settings.

DOI： 10.1016/j.archger.2025.105943

Prediabetes transitions to normoglycaemia or type 2 diabetes and associated risk factors in the Obesity, Diabetes and Cardiovascular Disease Collaboration: an individual-level pooled analysis of 19 prospective cohort studies 査読有り国際共著 Open Access

Davoodian, N; Lotfaliany, M; Huxley, RR; Lee, CMY; Pasco, JA; Adams, RJ; Azizi, F; Bertoni, AG; Björkelund, C; Colagiuri, S; Fahimfar, N; Gabriel, R; Giedraitis, V; Gill, TK; González, C; Gregg, EW; Hadaegh, F; Hange, D; Harland, JW; Hodge, AM; Holloway-Kew, KL; Hosseini, SR; Jacobs, DR ; Khalili, D; Magliano, DJ; Mongraw-Chaffin, M; Mishra, G; Lissner, L; Mehlig, K; Najafipour, H; Nieto-Martinez, R; Ostovar, A; Shadkam, M; Shaw, JE; Sundh, V; Schreiner, PJ; Sakurai, M; Wittert, GA; Yatsuya, H; Zethelius, B; Mohebbi, M

LANCET GLOBAL HEALTH 13 巻 ( 9 ) 2025年9月

Matsunaga, M; He, YP; Khine, MT; Shi, XL; Okegawa, R; Li, YY; Yatsuya, H; Ota, A

JOURNAL OF CANCER SURVIVORSHIP 19 巻 ( 4 ) 頁： 1346 - 1356 2025年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Cancer Survivorship

Purpose: The aim of this study is to evaluate the prevalence, severity, and risk factors of cancer-related fatigue among currently working cancer survivors. Methods: We searched the PubMed, Embase, Scopus, CINAHL, Cochrane Library, and ICHUSHI databases. The risk of bias was evaluated independently using the Risk of Bias Assessment Tool for Non-randomized Studies (RoBANS). A meta-analysis was conducted to determine the prevalence, severity, and related factors associated with cancer-related fatigue among currently working cancer survivors. Results: Our meta-analysis included 18 studies and revealed that 42.2% of currently working cancer survivors experience cancer-related fatigue. The fatigue severity in this group was significantly higher than that in workers without cancer (absolute standardized mean difference (SMD) = 0.67), but lower than that in cancer survivors who had previously worked and were not currently working (absolute SMD = 0.72). Distress was identified as a potential risk factor for cancer-related fatigue in working cancer survivors (partial correlation coefficient = 0.38). Conclusions: The high prevalence of cancer-related fatigue among employed cancer survivors underscores the need for targeted workplace interventions and fatigue management strategies. While the severity of fatigue is less than that seen in non-working survivors, the comparison with the general working population highlights a significant health disparity. The association between distress and fatigue suggests the necessity for a holistic approach to fatigue management that considers both physical and mental factors in working cancer survivors. Implications for Cancer Survivors: Our findings highlight the critical need for healthcare professionals and employers to monitor fatigue levels among working cancer survivors and offer appropriate support.

DOI： 10.1007/s11764-024-01557-8

その他リンク： https://link.springer.com/article/10.1007/s11764-024-01557-8/fulltext.html

Psychiatric and psychological adverse effects associated with dulaglutide, semaglutide, and liraglutide: A vigibase study 査読有り国際共著 Open Access

Nishida, K; Chrétien, B; Dolladille, C; Ebina, T; Aleksic, B; Cabé, N; Savey, V; Onoue, T; Yatsuya, H

CLINICAL NUTRITION 51 巻頁： 252 - 265 2025年8月

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Clinical Nutrition

Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are crucial in managing type 2 diabetes mellitus (T2DM) and obesity. Agents like dulaglutide, semaglutide, and liraglutide mimic endogenous GLP-1, enhancing insulin secretion and promoting satiety. Beyond glycemic control, they offer cardioprotective and neuroprotective benefits. However, concerns about psychiatric adverse effects have emerged, necessitating a systematic assessment of their safety profile. Material & Methods: This multinational pharmacovigilance study utilized VigiBase® data up to December 1, 2024, focusing on adverse drug reaction (ADR) reports for GLP-1 RAs. Psychiatric ADRs were classified using MedDRA terminology. Disproportionality analyses were conducted via logistic regression to calculate reporting adjusted Reporting Odds Ratios (aRORs) within reports involving antidiabetic or anti-obesity medications. A causal forest model assessed the individual treatment effect (ITE) of semaglutide on depression and suicidality reporting. Results: Among 2,061,901 reports, 21,414 involved psychiatric ADRs for GLP-1 RAs. Significant signals were observed for anxiety (aROR: 1.26, 95%CI: 1.18–1.35), depressed mood disorders (aROR: 1.70, 95%CI: 1.57–1.84) and suicidality (aROR 1.45, 95%CI: 1.29–1.63) with semaglutide, and eating disorders with all three GLP-1 RAs (aRORs between 4.17 and 6.80). The causal forest model estimated an average treatment effect of 0.0046 for semaglutide on depression and suicidality reporting, with significant heterogeneity across regions and demographic groups. Discussion: The study found no significant increase in overall psychiatric ADR reporting for GLP-1 RAs, except for eating disorders and depression/suicidality in semaglutide-treated patients. Sensitivity analyses before June 4, 2021, found no signals, aligning with RCT data. Post-marketing reports linked semaglutide to depression and suicidal ideation, prompting regulatory investigations. The causal forest model revealed significant heterogeneity in the psychiatric safety profile of semaglutide, with regional factors influencing ADR reporting. Conclusion: While GLP-1 RAs do not show a significant increase in overall psychiatric ADR reporting, findings suggest that clinicians should remain vigilant for potential depressive symptoms and suicidality, particularly in individuals with obesity treated with semaglutide since its approval for weight management.

DOI： 10.1016/j.clnu.2025.06.011

A comparison of the diagnostic ability of 1-mm computed tomography and 3-mm magnetic resonance imaging for detecting lateral pelvic lymph node metastases from rectal cancer 査読有り

Kobayashi, R; Uehara, K; Ebata, T; Yatsuya, H; Li, YY; Hida, K; Hashiguchi, Y; Ishihara, S; Ogawa, S; Shiomi, A; Kawai, K; Ajioka, Y

SURGERY TODAY 55 巻 ( 8 ) 頁： 1189 - 1197 2025年8月

記述言語：英語出版者・発行元：Surgery Today

Aim: The best modality for evaluating lateral pelvic lymph node (LPLN) metastases from rectal cancer remains unclear. This study compared the diagnostic ability of 1-mm computed tomography (CT) and 3-mm magnetic resonance imaging (MRI) in identifying LPLN metastases based on size. Methods: This observational study analyzed not individual patients but 191 sides from 100 rectal cancer patients without preoperative treatment for whom preoperative CT and MRI and corresponding pathological results for LPLNs were available. A swollen LPLN was defined as an LN with a short-axis size of ≥5 mm on 1-mm CT. Results: LPLNs were detected significantly more frequently with 1-mm CT than with 3-mm MRI (p < 0.001). Among the 117 sides without swollen LPLNs, metastasis was observed in 1.7% of patients. In contrast, LPLN metastasis was confirmed in 28.4% of 74 sides with swollen LPLNs. In the evaluation of swollen LPLNs, 3-mm MRI yielded a 34% improvement in the diagnostic performance of LPLN metastasis over 1-mm CT (categorical net reclassification improvement: 0.341, p = 0.045). Conclusions: In conclusion, 1-mm CT should be performed preoperatively to evaluate LPLNs. Further evaluations can be omitted in the absence of swollen LPLNs. In patients with swollen LPLNs, a careful assessment of LPLN metastasis should be conducted via additional MRI, even in early T-stage tumors.

DOI： 10.1007/s00595-025-03018-w

Lifestyle-attributable burden of young-onset stroke in Chinese and global populations aged 20-54 years: A three decades comparative study (1990-2021) using Global Burden of Disease study data 査読有り国際共著 Open Access

Yang, DR; Fan, GH; Cheng, JJ; Meng, QZ; Liu, KY; Shirai, K; Yatsuya, H; Chen, R; Zhang, Y

TOBACCO INDUCED DISEASES 23 巻 2025年8月

A comparison of modifiable risk factors for dementia among South Asian migrants and non-migrants aged 50 or older in Tasmania, Australia 査読有り国際共著 Open Access

Hamrah, MS; Alty, J; Goldberg, LR; Doherty, K; Kitsos, A; Bindoff, A; Roccati, E; Yatsuya, H; Vickers, JC

BMC PUBLIC HEALTH 25 巻 ( 1 ) 頁： 2362 2025年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMC Public Health

Background: South Asian migrants are one of the fastest-growing populations in Australia, particularly in the southern island state of Tasmania. However, there is limited research evaluating their modifiable dementia risk factors. This study aimed to fill this gap by comparing risk factors in South Asian migrants to non-migrant Australians in Tasmania. Methods: A cross-sectional study was conducted with 136 South Asian migrants and 2743 non-migrant Australians aged 50 or older residing in Tasmania. Participants completed a survey questionnaire. Logistic regression models were used to assess differences in the odds of reporting modifiable dementia risk factors between the two cohorts as they responded to a survey. Results: South Asian migrants had higher odds of reporting hypertension (OR, 5.5; 95% CI, 3.5 to 8.4; p < 0.001), hypercholesterolaemia (OR, 4.4; 95% CI, 2.3 to 6.4; p < 0.001), cognitive inactivity (OR, 16.9; 95% CI, 10.4 to 28.9; p < 0.001), diabetes (OR, 5.2; 95% CI, 3.5 to 7.6; p < 0.001), smoking (OR, 3.6; 95% CI, 1.7 to 7.1; p < 0.001) and nonadherence to a Mediterranean-type diet (OR, 7.4; 95% CI, 3.5 to 18.9; p < 0.001), compared to non-migrant Australians. However, South Asian migrants had lower odds of reporting alcohol consumption (OR, 0.25; 95% CI, 0.14 to 0.43; p < 0.001). Conclusions: The risk profiles were different between South Asian migrants and non-migrant Australians, highlighting the need for targeted interventions addressing group-specific risk factors. However, the use of convenience sampling for the South Asian migrant group may limit the representativeness of the findings and affect their generalizability. However, the use of convenience sampling and the relatively small sample size of the South Asian migrant group may limit the representativeness and generalizability of the findings. Additionally, the South Asian migrant group may represent a more socioeconomically disadvantaged population compared to the non-migrant sample, which may be relatively healthier and more financially advantaged than the general Tasmanian population. The study highlights the need for targeted, culturally appropriate interventions to address these risks. Further research is needed to comprehensively assess the prevalence and determinants of modifiable dementia risk factors among South Asian migrants.

DOI： 10.1186/s12889-025-23426-4

Risk factors for intracerebral hemorrhage by five specific bleeding sites: Japan Public Health Center-based Prospective Study 査読有り Open Access

Ariyada, K; Yamagishi, K; Kihara, T; Muraki, I; Imano, H; Kokubo, Y; Saito, I; Yatsuya, H; Iso, H; Tsugane, S; Sawada, N

EUROPEAN STROKE JOURNAL 10 巻 ( 2 ) 頁： 600 - 609 2025年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：European Stroke Journal

Background: Evaluating the risk factors for intracerebral hemorrhage is indispensable for primary prevention. However, the pathogenesis varies depending on the bleeding site, and few prospective studies have explored risk factors in detail for each site. Participants and methods: The Japan Public Health Center-based Prospective Study is a prospective study comprising a population-based sample of Japanese adults in 1990 (Cohort I) and in 1993 (Cohort II). A total of 34,137 participants (11,907 men and 22,230 women) were enrolled in this study and followed up until 2009 for Cohort I and until 2012 for Cohort II. The association between risk factors (age, sex, blood pressure, serum cholesterol, triglycerides, blood glucose, body mass index, smoking, and drinking status) and intracerebral hemorrhage by its bleeding site (lobes, putamen, thalamus, cerebellum, and brainstem) was assessed using Cox proportional hazards analysis. Results: During a median 20-year follow-up, 571 intracerebral hemorrhage events occurred. Hypertension was associated with an increased risk of total intracerebral hemorrhage, but not lobar hemorrhage. The multivariable hazard ratio (95% confidence intervals) was 2.09 (1.75–2.50) for total intracerebral hemorrhage. In contrast, a low serum total cholesterol level was associated only with lobar hemorrhage (1.73 (1.01–2.96)). Heavy drinking was associated with the risk of total and putamen hemorrhage, and obesity was associated with the risk of putamen hemorrhage. Discussion and conclusion: The present study identified different risk factors depending on the bleeding site of intracerebral hemorrhage.

DOI： 10.1177/23969873241290680

その他リンク： https://journals.sagepub.com/doi/full-xml/10.1177/23969873241290680

Utility of long-term systolic blood pressure variability for predicting the development of type 2 diabetes mellitus 査読有り

Song, Z; Li, YY; Hong, YJ; Chiang, CF; Matsunaga, M; He, YP; Ota, A; Tamakoshi, K; Yatsuya, H

NAGOYA JOURNAL OF MEDICAL SCIENCE 87 巻 ( 2 ) 頁： 220 - 236 2025年5月

担当区分：最終著者,　責任著者記述言語：英語出版者・発行元：Nagoya Journal of Medical Science

Better identification of individuals at high risk for type 2 diabetes mellitus (T2DM) requires risk-prediction models incorporating novel predictors. Accordingly, this study aimed to evaluate the merits of including long-term systolic blood pressure variability (SBPV) in predicting T2DM incidence in a Japanese cohort of 3017 participants (2446 men, 571 women; age, 36–65 years) in 2007, who were followed up until March 2019. Consecutive SBP values, recorded between 2003 and 2007, were regressed annually for each participant. The slope and root-mean-square error of the regression line were calculated for each individual to represent SBPV. The significance of SBPV was examined by adding it to a multivariate Cox model incorporating age, sex, smoking status, regular exercise, family history of diabetes, body mass index, blood levels of triglycerides, high-density lipoprotein cholesterol, and fasting blood glucose. The c-index, net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were used to compare the performance of the prediction models without (Model 1) and with (Model 2) SBPV. During the 9.8-year follow-up period, 135 participants developed T2DM. Although a statistically significant difference in c-index between Model 1 (0.785) and Model 2 (0.786) was not found, the NRI (8.312% [p < 0.001]) and IDI (0.700% [p = 0.012]) demonstrated that the performance of Model 2 improved compared with Model 1. In conclusion, results suggested that long-term SBPV slightly improved predictive utility for T2DM when added to a conventional prediction model. The study was registered at University Hospital Medical Information Network Clinical Trial registry (UMIN000052544, https://www.umin.ac.jp/).

DOI： 10.18999/nagjms.87.2.220

Association between eveningness and depressive symptoms in daytime workers: A cross-sectional analysis of the Aichi Workers' Cohort Study. 査読有り Open Access

Ishihara K, Kitajima T, Ota A, Yatsuya H, Iwata N

Fujita medical journal 11 巻 ( 2 ) 頁： 64 - 69 2025年5月

記述言語：英語出版者・発行元：Fujita Medical Journal

Objectives: Eveningness (evening preference in chronotype) has been reported to be associated with a number of psychiatric problems. We examined a cross-sectional association between eveningness and depressive symptoms in daytime workers. Methods: The subjects were 4410 civil servants (71.7% male, aged 18–69 years [mean, 43.5 years]) with no history of depressive disorder who did not perform shift work, and for whom there were no missing data. The association between eveningness, determined using the reduced Morningness–Eveningness Questionnaire, and depressive symptoms, determined using the shorter form of the Central Epidemiological Studies Depression scale, was assessed with logistic regression analysis adjusted for potential confounding factors (gender, income, living alone, breakfast intake, coffee consumption, drinking habits, exercise, smoking, working hours, sleep duration, and difficulty falling asleep). Results: Of the subjects, 529 (12.0%) had eveningness, and 1408 (31.9%) reported depressive symptoms. Depressive symptoms were reported more frequently by those with eveningness than by those with other chronotypes (57.3% vs 28.5%). The association between eveningness and depression (gender-and age-adjusted odds ratio, 3.27; 95% confidence interval, 2.71–3.95) was significant after adjustment for the other confounding factors (odds ratio, 2.40; 95% confidence interval, 1.96–2.95). Conclusions: Our results suggest that eveningness is associated with depressive symptoms among day workers and that this association is independent of potential confounding factors. Further longitudinal studies are needed to examine the causal relationship.

DOI： 10.20407/fmj.2024-021

Mortality after partner's cancer diagnosis or death: A population-based prospective cohort study in Japan 査読有り Open Access

Makiuchi, T; Kakizaki, M; Sobue, T; Kitamura, T; Yatsuya, H; Yamaji, T; Iwasaki, M; Inoue, M; Tsugane, S; Sawada, N

JOURNAL OF EPIDEMIOLOGY 35 巻 ( 3 ) 頁： 118 - 128 2025年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: The health statuses of closely connected individuals are interdependent. Little is known about mortality risk associated with partner’s cancer diagnosis and cause-specific mortality risk associated with partner’s death. Methods: Relative risks for all-cause and cause-specific mortality following a partner’s cancer diagnosis or death compared to the period when the partner is cancer-free and alive were investigated in the population-based prospective cohort study that enrolled 140,420 people at the age between 40–69 years in 1990–1994. Results: 55,050 participants (27,665 men and 27,385 women) who were identified as married couples were followed-up for 1,073,746.1 (518,368.5 in men and 555,377.6 in women) person-years, during which 9,816 deaths were observed (7,217 in men and 2,599 in women). After a partner’s cancer diagnosis, the mortality rate ratio (MRR) of all-cause mortality was not increased among both men and women, while an increase of externally-caused MRR was observed. The suicide MRR significantly increased among men (MRR 2.90; 95% confidence interval, 1.70–4.93), and it persisted for more than 5 years. After a partner’s death, the MRRs of all-cause, cardiovascular disease (CVD), respiratory disease (RD), and externally-caused mortality significantly increased only among men. Stratified analysis by smoking status among men showed significantly increased MRRs of CVD and RD mortality among former/current smokers, but not among never-smokers. Conclusion: Partner’s cancer diagnosis did not increase all-cause mortality risk, but increased externally-caused mortality risk, especially suicide among men. The impact of partner’s death on mortality risk differed by the mortality causes and sex, and smoking affected some of cause-specific mortality risk.

DOI： 10.2188/jea.JE20240114

日比野瑞歩, 李媛英, 宋澤安, 髙田碧, 洪英在, 福田知里, 王爽, 桶川龍世, 西尾七海, 服部優奈, 太田充彦, 玉腰浩司, 八谷寛

東海公衆衛生雑誌 12 巻 ( 2 ) 頁： 135 - 142 2025年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：東海公衆衛生学会

目的　中部地方の自治体職員を対象に，朝食欠食と5年後の抑うつ状態発症との関連を，愛知職域コホート研究のデータを用いて検討することを目的とした。方法　愛知職域コホート研究の2013年のベースライン調査に参加した20-54歳の対象者のうちベースライン時に抑うつがない,あるいはうつ病の治療中ではない者のうち2018年調査にも参加した2004人 (男性1452人,女性552人)を研究対象とした。抑うつ状態の評価はCenter for Epidemiologic Studies Depression Scale日本語短縮 (11項目)を使用し，8点以上を抑うつとみなした。朝食欠食は朝食摂取頻度が週6回以下と定義した。さらに，5年間の朝食欠食の変化を「非欠食 (2013年)→非欠食 (2018年)」，「欠食→非欠食」，「非欠食→欠食」，「欠食→欠食」の4パターンに分けた分析も実施した。多変量ロジスティック回帰分析を用いて，性 (男性，女性[閉経前]，女性[閉経後])，年齢，学歴，配偶者・14歳未満の子供の同居の有無，肥満 (BMI≧25 kg/m2），喫煙状況，運動頻度，アルコール摂取量，睡眠時間，ストレス，ファミリー・ワーク・コンフリクト，ワーク・ファミリー・コンフリクトを調整し，2018年の抑うつ発症のオッズ比 (OR)と95%信頼区間 (CI)を推定した。結果　2018年に新たに抑うつ状態となったのは261人 (13%)であった。朝食欠食と抑うつ発症には調整要因に独立した統計学的に有意な正の関連が認められた (OR: 1.39，95%CI: 1.01-1.90)。朝食欠食の変化パターン別の分析でも「非欠食→非欠食」群に比べて「欠食→欠食」群は抑うつ発症と有意な正の関連を示した (OR: 1.53，95%CI: 1.06-2.21)。結論　朝食欠食と抑うつ発症には調整要因に独立した正の関連が認められた。

DOI： 10.24802/tpha.2024-07

都市部職域コホートにおける危険因子の集積と心血管疾患発症リスクとの関連及びその集団寄与危険割合査読有り

田島里菜, 宋澤安, 洪英在, 福田知里, 史旭良, 吉田裕子, 清水宏子, 村上美晴, 小林芽生, 中野嘉久, 松永眞章, 太田充彦, 玉腰浩司, 八谷寛

日本循環器病予防学会誌 60 巻 ( 1 ) 頁： 64 - 73 2025年2月

記述言語：日本語出版者・発行元：一般社団法人日本循環器病予防学会

【目的】心血管疾患 (冠動脈疾患及び脳卒中) の発症予防のために、我が国では腹部肥満の存在を必須とするメタボリックシンドロームに着目した特定健診・特定保健指導が実施されている。しかし、非肥満者であっても危険因子の存在や集積が心血管疾患発症リスクとなり、日本人ではその割合が大きいことから、非肥満者で危険因子を有する者への保健指導実施の必要性が指摘されている。肥満の有無による危険因子集積数と心血管疾患発症との関連については、地方住民を対象とした研究が多く、都市部職域勤労者を対象とした研究は少ない。そこで本研究は都市部の自治体職員を対象とする愛知職域コホート研究において、危険因子とその集積数による心血管疾患発症リスク及び集団寄与危険割合 (PAF) を肥満の有無別に推定することを目的とした。【方法】2002～08年をベースラインとする愛知職域コホート研究対象者の内、心血管疾患・がん既往のある者、血圧・血糖・脂質・肥満度・蛋白尿・喫煙に欠損のある者、追跡期間1年未満の者を除外した7,179人を対象とした。高血圧 (収縮期血圧≧140 mmHgかつ／又は拡張期血圧≧90 mmHg、又は高血圧治療者)、糖尿病 (空腹時血糖≧126 mg/dL又はHbA1c≧6.5％、又は糖尿病治療者)、高LDLコレステロール血症 (LDLコレステロール≧140 mg/dL又は脂質異常症治療者)、腎臓病 (尿蛋白±以上、又は腎臓病治療者)、現喫煙の5つの危険因子の保有数 (0、1、2、≧3) により4群に分け、心血管疾患発症との関連について多変量調整Cox比例ハザードモデルによるハザード比 (HR) と人口寄与危険度割合 (PAF) を推定した。【結果】追跡期間中の心血管疾患発症者数は99名 (非肥満群66名、肥満群33名) であった。非肥満者で危険因子を有さない群と比較し、非肥満者で危険因子1個の群 (HR: 2.43, 95％CI: 1.14-5.21)、2個の群 (HR: 3.96, 95％CI: 1.79-8.74)、3個以上の群 (HR: 4.75, 95％CI: 1.73-13.0)、肥満者で危険因子1個の群 (HR: 4.31, 95％CI: 1.85-10.00)、2個の群 (HR: 3.75, 95％CI: 1.47-9.57)、3個以上の群 (HR: 7.53, 95％CI: 2.86-19.8) における心血管疾患発症リスクは有意に高かった。PAFは、非肥満者で危険因子1個の群、2個の群、3個以上の群でそれぞれ16.7％、16.6％、5.6％、肥満者の危険因子1個の群、2個の群、3個以上の群でそれぞれ10.9％、6.7％、7.0％でいずれも有意であった。【結論】肥満の有無によらず危険因子が集積するほど心血管疾患発症リスクは高くなった。危険因子2個以上の集積によるPAFの合計は非肥満群で22.2％、肥満群で13.7％であった。

DOI： 10.11381/jjcdp.60.1_64

Associations of maternal urinary nitrophenol concentrations with adverse birth outcomes and neurodevelopment delay at 4 years of age: The Japan environment and children's study 査読有り

Sex-specific association of comorbid heart failure on mortality after Alzheimer's disease diagnosis in older adults aged 75 years and above: A health insurance claims data analysis in Japan 査読有り Open Access

Matsunaga, M; Tanihara, S; He, YP; Yatsuya, H; Ota, A

JOURNAL OF ALZHEIMERS DISEASE 103 巻 ( 3 ) 頁： 749 - 757 2025年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Alzheimer S Disease

Background: Research on the influence of heart failure on mortality after Alzheimer's disease diagnosis is limited. Objective: To evaluate the association between comorbid heart failure and mortality following Alzheimer's disease diagnosis, particularly considering sex differences. Methods: We analyzed administrative claims data from Japan, involving 32,363 individuals (11,064 men and 21,299 women) aged 75 or older newly diagnosed with Alzheimer's disease, with 7% having comorbid heart failure. Cox proportional hazard models and population attributable fractions (PAFs) were used to evaluate the association between comorbid heart failure and mortality within one year following Alzheimer's disease diagnosis. Results: Individuals with Alzheimer's disease and heart failure had a multivariate-adjusted hazard ratio of 1.51 (95% confidence interval [CI], 1.32–1.73) for mortality during the one-year follow-up period compared to those with Alzheimer's disease and without heart failure. Subgroup analysis by sex revealed a higher mortality hazard ratio in women of 1.63 (95% CI, 1.36–1.95) than that in men of 1.39 (95% CI, 1.13–1.71). Further age and sex subgroup analysis indicated that women across all age brackets—75–79, 80–84, and ≥ 85 years—had higher mortality hazard ratios. The PAF for heart failure increased with age in both sexes, with women having higher PAFs than men, and the sex difference in PAF being most pronounced in the 75–79 age category (men: 1.4%, women: 4.0%). Conclusions: Hazard ratios and PAFs for mortality associated with comorbid heart failure in newly diagnosed Alzheimer's disease are higher in women than in men, which persists across all age subgroups.

DOI： 10.1177/13872877241305813

その他リンク： https://journals.sagepub.com/doi/full-xml/10.1177/13872877241305813

Exploring the development of safety culture among physicians with text mining of patient safety reports: a retrospective study 査読有り Open Access

Koike, D; Ito, M; Horiguchi, A; Yatsuya, H; Ota, A

INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE 37 巻 ( 1 ) 頁： mzae108 2025年1月

記述言語：英語出版者・発行元：International Journal for Quality in Health Care

Background: Safety culture development is essential for patient safety in healthcare institution. Perceptions of patient safety and cultural changes are reflected in patient safety reports; however, they were rarely investigated. The aim of this study was to investigate the perception of physicians and to explore the development of safety culture using quantitative content analysis for patient safety reports. Methods: A retrospective analysis of free descriptions of harmful patient safety reports submitted by physicians was performed. Natural language processing and text analysis were conducted using the "KH Coder."A co-occurrence analysis was performed in each period to identify and analyze the safety concepts. The study period was grouped into three for comparison. Results: The patient safety reports from physicians were collected between April 2004 and March 2020. Of these, 3351 reports were harmful: 839 reports were included in period 1, 1016 reports in period 2, and 1496 reports in period 3. Natural language processing identified 316 307 words in the free descriptions of 3351 reports. We identified seven concepts from the cluster in co-occurrence analysis as follows: "explanation of adverse event to patients and families,""central venous catheter,""intraoperative procedure and injury,""minimally invasive surgery,""life-Threatening events,""blood loss,"and "medical emergency team and critical care."These seven concepts showed significant differences among the three periods, except for "blood loss."The "explanation of adverse event to patients and families"decreased in proportion from 11.3% to 8.8% (P <. 05). The "central venous catheter"decreased from 17.3% to 11.3% (P <. 01). Meanwhile, "minimally invasive surgeries"and "intraoperative procedures"increased from 3.9% to 12.9% (P <. 01) and from 10.8% to 14.6% (P <. 05), respectively. Focusing on patients' events, "life-Threatening events"decreased from 13.0% to 8.1% (P <. 01); however, "medical emergency teams and critical care"increased from 3.3% to 10.6% (P <. 01). Conclusion: Free description in patient safety reports is useful for evaluating the safety culture. Co-occurrence analysis revealed multiple concepts of physicians' perceptions. Quantitative content analysis revealed changes in perceptions and attitudes, and a disclosure policy of adverse events and the priority of patient care appeared with the development of safety culture.

DOI： 10.1093/intqhc/mzae108

Kaneko, K; Ito, Y; Ebara, T; Yatsuya, H; Sugiura-Ogasawara, M; Saitoh, S; Sekiyama, M; Isobe, T; Kamijima, M

ENVIRONMENTAL RESEARCH 264 巻 ( Pt 1 ) 頁： 120290 - 120290 2025年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Environmental Research

Maternal urinary nitrophenol concentrations are reportedly associated with preterm birth and foetal/offspring development delay, but the evidence is still inconclusive. We investigated the association between maternal urinary concentrations of 4-nitrophenol (4NP) and 3-methyl-4-nitrophenol (3M4NP) and adverse birth outcomes, as well as offspring neurodevelopment delay, defined using the Ages and Stages Questionnaires at 4 years of age, stratified by offspring sex. A total of 3650 non-hypertensive mothers with singleton births were enrolled from the Japan Environment and Children's Study. High 4NP (≥0.41 μg/L) and 3M4NP (≥0.29 μg/L) were defined as ≥ lowest concentration minimum reporting level. Four groups were created using these dichotomized 4NP and 3M4NP concentrations: ‘both low’, ‘either high/low’, and ‘both high’. Multivariable logistic regression models were used to estimate the adjusted odds ratios (aOR) and population attributable fraction (PAF). For 4NP and 3M4NP, 68.4% and 19.0% of participants had ’high’ urinary concentrations, respectively. Compared to ‘both low’, the overall analysis showed no significant associations between ‘both high’ and any of the outcomes. However, the stratified analysis showed that the aOR (95% confidence interval [CI]) and PAF (95% CI) for ‘both high’ regarding preterm birth (<37 weeks' gestation) were 2.7 (1.3, 5.7) and 16.3% (2.5%, 28.1%), respectively, in male offspring. Among female offspring, the aOR and PAF for the ‘both high’ regarding small-for-gestational-age (SGA)—defined as weight-for-gestational age <10 percentile based on the Japanese neonatal anthropometric charts—were 1.7 (1.0, 2.8) and 10.6% (−0.2%, 20.2%), respectively. Urinary 4NP and 3M4NP concentrations showed no association with low birth weight (<2500 g) and neurodevelopment delay. In conclusion, offspring sex-specific associations of maternal urinary nitrophenols with preterm birth and SGA were observed. Even slight elevations in their levels may explain a certain proportion of preterm birth and SGA. The exposure source, expressed by urinary nitrophenols, should be identified.

DOI： 10.1016/j.envres.2024.120290

Lifetime Risk of Incident Coronary Heart Disease, Stroke, and Cardiovascular Disease: The Japan Public Health Center-Based Prospective Study 査読有り Open Access

Saito, I; Yamagishi, K; Kokubo, Y; Yatsuya, H; Muraki, I; Iso, H; Inoue, M; Tsugane, S; Sawada, N

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 32 巻 ( 1 ) 頁： 48 - 57 2025年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Atherosclerosis and Thrombosis

Aim: The constellation of cardiovascular disease (CVD) risk factors greatly impacts the lifetime risk (LTR) of incident CVD, but the LTR has not been thoroughly evaluated in the Japanese population. Methods: We conducted a prospective study involving a total of 25,896 individuals 40-69 years old without a history of CVD in 1995 (Cohort I) and 1993-1994 (Cohort II) in Japan. CVD risk factors (blood pressure, non-high-density lipoprotein [HDL] cholesterol levels, smoking status, and glucose concentrations) were used to stratify them by risk. The sex-specific LTR of incident coronary heart disease, stroke, atherosclerotic CVD, and total CVD were estimated for participants 45 years old in the 4 risk categories with the cumulative incidence rate, adjusting for the competing risk of death. Results: We found apparent differences in the LTR of total CVD according to the risk stratification. Individuals with ≥ 2 of the risk factors of blood pressure ≥ 140/90 mmHg or treated, non-HDL cholesterol level ≥ 170 mg/ dL or treated, current smoker, and diabetes had substantially higher adjusted LTRs of CVD than those in other groups, with a LTR of 26.5% (95% confidence interval, 24.0%-29.0%) for men and 15.3% (13.1%-17.5%) for women at 45 years. The LTR of incident stroke was the highest among CVDs, and the presence of hypertension and diabetes mellitus strongly influenced the LTR of total CVD. Conclusion: The impact of risk accumulation on LTR of CVD was greater in men, and 1 in 4 men with ≥ 2 major risk factors at 45 years of age developed CVD in their lifetime.

DOI： 10.5551/jat.64934

Association between fasting blood glucose level and difficulty with chewing: the Aichi Workers' Cohort Study Open Access

Hamrah, MH; Song, Z; Hong, Y; Akter, T; Nuamah, HG; Gondo, N; Matsunaga, M; Ota, A; Takada, M; Otsuka, R; Tamakoshi, K; Yatsuya, H

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE 30 巻 ( 0 ) 頁： 95 - 95 2025年

記述言語：英語出版者・発行元：Environmental Health and Preventive Medicine

Background: Difficulty in chewing has been shown to be associated with increased mortality, geriatric syndromes, and poor activities of daily living, indicating the need for intervention. Chewing difficulties are related to tooth loss, periodontitis, dry mouth, and a number of oral health conditions. Diabetes mellitus (DM) is one of the major causes of global burden of diseases, and has been associated with poor oral health. Prospective association between oral health status and the development of diabetes has also been reported. However, relationship between glycemic control and self-reported chewing difficulty remains less explored in working-age populations. The objective of this study is to cross-sectionally explore the association between fasting blood glucose (FBG) and self-reported chewing difficulty in adults working in a Japanese worksite. Methods: Participants from the Aichi Workers’ Cohort Study who responded to the 2018 survey were included. Participants were categorized into five FBG groups (<100, 100–109, 110–125, 126–159, and ²160 mg/dl). Multivariable odds ratios (ORs) and 95% confidence intervals (CIs) for chewing difficulty were estimated using logistic regression adjusted for age, sex, body mass index, smoking and alcohol consumption status, number of teeth, presence of periodontal disease and the number of anti-diabetic medication classes. Results: A total of 164 participants (4.2%) reported difficulty with chewing, the prevalence of which tended to increase with increasing FBG level. FBG ²160 mg/dl was significantly and strongly associated with difficulty with chewing in the final multivariable model (multivariable OR 3.84 [95% CI 1.13–13.0]). Conclusions: A relationship between higher FBG levels and difficulty with chewing was observed, independent of potential confounding factors. However, prospective or interventional studies are needed to determine causality.

DOI： 10.1265/ehpm.25-00284

Association between predicted level of water turnover deficit and all-cause and cause-specific mortalities among Japanese adults: The Japan Collaborative Cohort Study 査読有り国際誌 Open Access

Watanabe, D; Muraki, I; Yatsuya, H; Tamakoshi, A

AMERICAN JOURNAL OF CLINICAL NUTRITION 120 巻 ( 6 ) 頁： 1399 - 1408 2024年12月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：American Journal of Clinical Nutrition

Background: Although water is essential for maintaining health and life, the association between water turnover as an indicator of daily water requirement and water deficit and mortality is unclear. Objectives: We aimed to investigate this association in Japanese adults. Methods: A total of 63,488 (36,739 females and 26,749 males) Japanese aged 40–79 y in the Japan Collaborative Cohort Study in 1988–1990 were followed up their mortality through 2009. Water turnover was calculated considering lifestyle and environmental factors using an equation previously developed by the International Doubly Labeled Water Database Group. Participants were classified into sex-specific quintiles based on their water turnover. Water deficit levels were calculated from water turnover and dietary water consumption, which were estimated using a validated questionnaire. Results: The mean daily water turnovers were 2950 and 3466 mL in females and males, respectively. During 19.4 years of median follow-up (1,039,914 person-years), 12,551 deaths were recorded. After adjusting for lifestyle and medical history, the bottom quintile was associated with higher hazard ratios (HRs) of mortality from all causes (females—HR: 1.26; 95% CI: 1.12, 1.41; males—HR: 1.18; 95% CI: 1.07, 1.29) and cardiovascular disease (CVD). In spline analyses, the water turnover range with the lowest HR for all-cause mortality was 3000–3300 mL/d in females and the water turnover at which the HR for all-cause mortality plateaued was ∼3500–3700 mL/d in males. Water deficiency levels were associated with all-cause and CVD-related mortality in both sexes. Conclusions: The association between water turnover and deficit and all-cause and CVD-related mortalities (especially coronary artery disease and ischemic stroke) in adults is L-shaped. These findings may be useful for setting the target values of water requirement, and differences between dietary requirements and actual intake may bridge the knowledge gap in water–mortality associations.

DOI： 10.1016/j.ajcnut.2024.09.021

RISK FACTORS FOR INTRACEREBRAL HEMORRHAGE BY BLEEDING SITE

Ariyada, K; Yamagishi, K; Kihara, T; Muraki, I; Imano, H; Kokubo, Y; Saito, I; Yatsuya, H; Inoue, M; Tsugane, S; Iso, H; Sawada, N

ATHEROSCLEROSIS 399 巻 2024年12月

Chronotype and leisure-time physical activity among civil servants in Japan: a cross-sectional analysis of the Aichi workers' cohort study 査読有り Open Access

Okegawa, R; He, YP; Matsunaga, M; Khine, MT; Li, YY; Kitajima, T; Yatsuya, H; Ota, A

ARCHIVES OF PUBLIC HEALTH 82 巻 ( 1 ) 頁： 205 2024年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Archives of Public Health

Background: The association between chronotype and leisure-time physical activity (LTPA) remains unclear. We investigated the difference in regular LTPA and for a sufficient duration between those with evening-type (ET) and morning-type chronotypes (MT). Methods: We conducted a cross-sectional analysis using the data of the Aichi Workers’ Cohort Study. It included 3,221 men (mean [standard deviation] age: 45.0 [11.6] years) and 1,294 women (39.8 [11.2] years). Chronotypes were determined with the reduced version of the Morningness-Eveningness Questionnaire. We calculated the metabolic equivalents (METs) consumed per week based on the four types of LTPA: strolling, brisk walking, light- and moderate-intensity PA, and vigorous-intensity PA. Regular LTPA and for a sufficient duration was defined as doing once or more per week and for 30 min or longer per session, respectively. Logistic regression analysis was conducted separately by sex to calculate odds ratios of ET for regular LTPA and for a sufficient duration, adjusted for age and other factors, for each type of LTPA. Results: ET men consumed fewer total METs per week than MT men (p <.001), although this pattern is not found in women. Compared to MT men, ET men were less likely to be engaged in regular LTPA in all types of LTPA (prevalence and adjusted odds ratio [95% confidence interval]: strolling: 39.1% vs. 28.7%, 0.685 [0.524–0.895]; brisk walking: 23.9% vs. 14.4%, 0.639 [0.454–0.899]; light- and moderate-intensity PA: 15.4% vs. 8.4%, 0.613 [0.404–0.929]; vigorous-intensity PA: 21.4% vs. 16.8%, 0.715 [0.518–0.989]). They were less likely to spend a sufficient duration in brisk walking (25.9% vs. 16.5%, 0.635 [0.461–0.875]), light- and moderate-intensity PA (37.1% vs. 26.8%, 0.684 [0.521–0.899]), and vigorous-intensity PA (35.3% vs. 35.8%, 0.741 [0.568–0.968]). Compared with MT women, ET women were less likely to be engaged in strolling (30.5% vs. 22.2%, 0.629 [0.398–0.995]), and less likely to spend a sufficient duration in light- and moderate-intensity PA (27.3% vs. 15.3%, 0.561 [0.335–0.937]). Conclusions: ET was inversely associated with LTPA in men and partly in women.

DOI： 10.1186/s13690-024-01440-z

その他リンク： https://link.springer.com/article/10.1186/s13690-024-01440-z/fulltext.html

Factors influencing interprofessional collaboration in long-term care from a multidisciplinary perspective: a case study approach 査読有り

Yoshida, Y; Hirakawa, Y; Hong, YJ; Mamun, MR; Shimizu, H; Nakano, Y; Yatsuya, H

HOME HEALTH CARE SERVICES QUARTERLY 43 巻 ( 4 ) 頁： 239 - 258 2024年10月

記述言語：英語出版者・発行元：Home Health Care Services Quarterly

Systematic assessments of interprofessional collaboration barriers and enablers in long-term care settings are critical for delivering person-centered healthcare. However, research on factors influencing interprofessional collaboration in long-term care settings is limited. For this study, 65 healthcare professionals across multiple facilities experienced in long-term care in Japan participated in online focus group discussions and individual interviews to discuss cases. The qualitative data were analyzed using qualitative content analysis. Seven themes emerged: coordination, the need for care manager training, hierarchy among healthcare professionals, specialization but not the mind-set of overspecialization, casual conversations, electronic group communication tools, and excessive fear of personal information protection. These findings highlight the need to develop coordinator roles and for interprofessional education on the proper approach to personal information protection laws. Furthermore, daily casual conversations, the use of online platforms, and the prevention of patients being left behind due to overspecialization are required.

DOI： 10.1080/01621424.2024.2331452

Global, regional, and national burden of stroke and its risk factors, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021 Open Access

Feigin, VL; Abate, MD; Abate, YH; Abd ElHafeez, S; Abd-Allah, F; Abdelalim, A; Abdelkader, A; Abdelmasseh, M; Abd-Elsalam, S; Abdi, P; Abdollahi, A; Abdoun, M; Abd-Rabu, R; Abdulah, DM; Abdullahi, A; Abebe, M; Zuniga, RAA; Abhilash, ES; Abiodun, OO; Abiodun, O; Kasem, RA; Aboagye, RG; Abouzid, M; Abreu, LG; Abrha, WA; Abtahi, D; Abu Rumeileh, S; Abualhasan, A; Abualruz, H; Abu-Gharbieh, E; Abukhadijah, HJ; Abu-Rmeileh, NME; Aburuz, S; Abu-Zaid, A; Acuna, JM; Adane, DE; Adane, MM; Addo, IY; Adedoyin, RA; Adegboye, OA; Adekanmbi, V; Adhikari, K; Adnani, QES; Adra, S; Adzigbli, LA; Afify, AY; Afolabi, AA; Afrashteh, F; Afzal, MS; Afzal, S; Aghamiri, S; Agyemang-Duah, W; Ahinkorah, BO; Ahmad, A; Ahmad, MM; Ahmad, S; Ahmad, S; Ahmad, T; Ahmadzade, AM; Ahmed, A; Ahmed, A; Ahmed, H; Ahmed, SA; Ajami, M; Aji, B; Akara, EM; Akinyemi, RO; Akkaif, MA; Akrami, AE; Al Awaidy, S; Al Hamad, H; Al Hasan, SM; Al Qadire, M; Al Ta'ani, O; Al-Ajlouni, Y; Alalalmeh, SO; Alalwan, TA; Al-Aly, Z; Al-amer, RM; Aldhaleei, WA; Aldossary, MS; Alemohammad, SY; Al-Fatly, B; Al-Gheethi, AAS; Alhalaiqa, FN; Alharrasi, M; Ali, A; Ali, MU; Ali, R; Ali, SS; Ali, W; Al-Ibraheem, A; Alif, SM; Aljunid, SM; Almahmeed, W; Al-Marwani, S; Alomari, MA; Alonso, J; Alqahtani, JS; Al-Raddadi, RMM; Alrawashdeh, A; Alsabri, MA; Alshahrani, NZ; Altaany, Z; Altaf, A; Al-Tammemi, AB; Altwalbeh, D; Alvis-Guzman, N; Alwafi, H; Al-Wardat, M; Al-Worafi, YM; Aly, H; Aly, S; Alyahya, MSI; Alzoubi, KH; Al-Zyoud, WA; Amani, R; Amegbor, PM; Amera, TG; Amin, TT; Amindarolzarbi, A; Amiri, S; Amu, H; Amugsi, DA; Amusa, GA; Ancuceanu, R; Anderlini, D; Angappan, D; Anil, A; Ansari, MTT; Ansari-Moghaddam, A; Ansong, R; Anvari, S; Anwar, S; Anwar, SL; Anyabolo, EE; Anyasodor, AE; Apostol, GLC; Appiah, F; Aqeel, M; Arabloo, J; Bahri, RA; Arafat, M; Aravkin, AY; Ardekani, A; Areda, D; Aregawi, BB; Aregu, GM; Aremu, O; Arifin, H; Ärnlöv, J; Artamonov, AA; Arulappan, J; Aryal, UR; Aryan, Z; Asbeutah, AM; Asemahagn, MA; Asemu, MT; Asghari-Jafarabadi, M; Ashemo, MY; Ashraf, T; Aslani, A; Asmerom, HA; Astell-Burt, T; Athari, SS; Atorkey, P; Atout, MMW; Atreya, A; Aujayeb, A; Ausloos, M; Avan, A; Awad, H; Awotidebe, AW; Ayana, LAA; Aychiluhm, SB; Aynalem, AA; Aynalem, ZB; Azadnajafabad, S; Azami, H; Aziz, S; Azzam, AY; Babu, AS; Babu, GR; Badar, M; Badiye, AD; Taghanaki, PB; Bahramian, S; Bai, R; Baig, AA; Bakkannavar, SM; Bako, AT; Baltatu, OC; Bam, K; Banach, M; Banakar, M; Bandyopadhyay, S; Banik, PC; Bansal, K; Bao, YP; Barboza, MA; Bardhan, M; Barengo, NC; Barker-Collo, SL; Bärnighausen, TW; Barqawi, HJ; Barrow, A; Barua, L; Bashiri, A; Bashiru, HA; Basiru, A; Bastan, MM; Basu, S; Basu, S; Batra, K; Begde, A; Behnam, B; Behnoush, AH; Belayneh, MBY; Belingheri, M; Bello, UM; Bennett, DA; Bensenor, IM; Berhe, FT; Bermudez, ANC; Beyene, HBB; Beyene, KA; Bhagat, DS; Bhagavathula, AS; Bhala, N; Bhalla, A; Bhardwaj, N; Bhardwaj, P; Bhaskar, S; Bhat, AN; Bhat, V; Bhatti, GK; Bhatti, JSS; Bhuiyan, MA; Bhusal, S; Bikbov, B; Bilgin, C; Biondi, A; Bishaw, KA; Biswas, A; Biswas, B; Bodhare, T; Bogale, EK; Boloor, A; Hashemi, MB; Bonny, A; Basara, BB; Borhany, H; Bosoka, SA; Bouaoud, S; Bouyahya, A; Boyko, EJ; Bozic, MM; Braithwaite, D; Breitner, S; Brenner, H; Britton, G; Brunoni, AR; Bryazka, D; Bugiardini, R; Bulto, LN; Burkart, K; Bustanji, Y; Butt, ZA; dos Santos, FLC; Cámera, LA; Campos, LA; Campos-Nonato, IR; Cao, F; Capodici, A; Cárdenas, R; Carr, S; Carreras, G; Carvalho, AF; Carvalho, F; Castaldelli-Maia, JM; Castañeda-Orjuela, CA; Castelpietra, G; Catapano, AL; Cattaruzza, MS; Cegolon, L; Cembranel, F; Cenko, E; Cerin, E; Chadwick, J; Chakraborty, C; Chakraborty, S; Chan, JSK; Chandika, RM; Chandrasekar, EK; Chanie, GS; Chattu, VK; Chaudhary, AA; Chaurasia, A; Chen, HW; Chen, ML; Chen, SM; Chi, G; Chichagi, F; Chimoriya, R; Ching, PR; Chitheer, A; Cho, SMJ; Choi, DW; Chong, B; Chong, CL; Chopra, H; Choudhari, SG; Choudhary, R; Chu, DT; Chukwu, IS; Chung, SC; Cindi, Z; Cioffi, I; Cogen, RM; Columbus, A; Costanzo, S; Couto, RAS; Criqui, MH; Cruz-Martins, N; Cuadra-Hernández, SM; da Silva, AG; Dadana, S; Dadras, O; Dai, XC; Dalal, K; Dalli, LL; Damiani, G; D'Amico, E; Dandona, L; Dandona, R; Darwish, AH; Das, S; Dashti, M; Dashtkoohi, M; Dashtkoohi, M; Dastmardi, M; Davletov, K; De la Cruz-Góngora, V; DeAngelo, S; Debele, AT; Debopadhaya, S; Delgado-Enciso, I; Demessa, BH; Demetriades, AK; Denova-Gutiérrez, E; Dervisevic, E; Desai, HD; Desale, AT; Desta, F; Devanbu, VGC; Devegowda, D; Dewan, SMR; Dhane, AS; Dhimal, M; Dhulipala, VR; Diaz, MJ; Diress, M; Dodangeh, M; Doegah, PT; Dohare, S; Doheim, MF; Dokova, KG; Dongarwar, D; D'Oria, M; Doshi, OP; Doshi, RP; Douiri, A; Dowou, RK; Dsouza, AC; Dsouza, HL; Dsouza, VS; Duncan, BB; Duraes, AR; Dziedzic, AM; Ekholuenetale, M; El Bayoumy, IF; Zaki, ME; Elbarazi, I; El-Dahiyat, F; Elgendy, IY; Elhadi, M; El-Huneidi, W; Elmonem, MA; Elmoselhi, AB; Eltaha, C; Emeto, TI; Esezobor, CI; Esfandiari, N; Esmaeili, Z; Esposito, F; Etoom, M; Fabin, N; Fadhil, I; Fagbamigbe, AF; Fagbule, OF; Faghani, S; Fahim, A; Fakhradiyev, IR; Falzone, L; Fareed, M; Fares, J; Farinha, CSES; Faris, MEM; Faris, PS; Kouhanjani, MF; Faro, A; Farrokhpour, H; Fasanmi, AO; Fauk, NK; Fazeli, P; Fazylov, T; Feizkhah, A; Fekadu, G; Feng, XQ; Fereshtehnejad, SM; Ferrara, P; Ferreira, N; Fetensa, G; Feyisa, BR; Fischer, F; Flor, LS; Foley, KM; Fonseca, AC; Foroumadi, R; Foroutan, B; Fortuna, D; Foschi, M; Franklin, RC; Fridayani, NKY; Sridevi, G; Gaal, PA; Gaidhane, AM; Gaipov, A; Galali, Y; Gallus, S; Gandhi, AP; Ganesan, B; Gasevic, D; Gautam, P; Gautam, RK; Gebregergis, MW; Gebrehiwot, M; Gebrekidan, KG; Getacher, L; Getahun, GK; Getie, M; Ghadimi, DJ; Ghadirian, F; Jolfayi, AG; Ghafourifard, M; Ghasemi, MR; Ghasemzadeh, A; Ghazy, RM; Gholami, E; Gholami, Z; Ghozy, S; Luza, SG; Gilani, JA; Gill, TK; Gillum, RF; Gindaba, EZ; Gnedovskaya, EV; Goel, A; Goldust, M; Golechha, M; Goleij, P; Golinelli, D; Gona, PN; Gorini, G; Goulart, AC; Goulart, BNG; Gouravani, M; Grivna, M; Grosso, G; Grover, A; 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LANCET NEUROLOGY 23 巻 ( 10 ) 頁： 973 - 1003 2024年10月

掲載種別：研究論文（学術雑誌）出版者・発行元：Lancet Neurology

Background: Up-to-date estimates of stroke burden and attributable risks and their trends at global, regional, and national levels are essential for evidence-based health care, prevention, and resource allocation planning. We aimed to provide such estimates for the period 1990–2021. Methods: We estimated incidence, prevalence, death, and disability-adjusted life-year (DALY) counts and age-standardised rates per 100 000 people per year for overall stroke, ischaemic stroke, intracerebral haemorrhage, and subarachnoid haemorrhage, for 204 countries and territories from 1990 to 2021. We also calculated burden of stroke attributable to 23 risk factors and six risk clusters (air pollution, tobacco smoking, behavioural, dietary, environmental, and metabolic risks) at the global and regional levels (21 GBD regions and Socio-demographic Index [SDI] quintiles), using the standard GBD methodology. 95% uncertainty intervals (UIs) for each individual future estimate were derived from the 2·5th and 97·5th percentiles of distributions generated from propagating 500 draws through the multistage computational pipeline. Findings: In 2021, stroke was the third most common GBD level 3 cause of death (7·3 million [95% UI 6·6–7·8] deaths; 10·7% [9·8–11·3] of all deaths) after ischaemic heart disease and COVID-19, and the fourth most common cause of DALYs (160·5 million [147·8–171·6] DALYs; 5·6% [5·0–6·1] of all DALYs). In 2021, there were 93·8 million (89·0–99·3) prevalent and 11·9 million (10·7–13·2) incident strokes. We found disparities in stroke burden and risk factors by GBD region, country or territory, and SDI, as well as a stagnation in the reduction of incidence from 2015 onwards, and even some increases in the stroke incidence, death, prevalence, and DALY rates in southeast Asia, east Asia, and Oceania, countries with lower SDI, and people younger than 70 years. Globally, ischaemic stroke constituted 65·3% (62·4–67·7), intracerebral haemorrhage constituted 28·8% (28·3–28·8), and subarachnoid haemorrhage constituted 5·8% (5·7–6·0) of incident strokes. There were substantial increases in DALYs attributable to high BMI (88·2% [53·4–117·7]), high ambient temperature (72·4% [51·1 to 179·5]), high fasting plasma glucose (32·1% [26·7–38·1]), diet high in sugar-sweetened beverages (23·4% [12·7–35·7]), low physical activity (11·3% [1·8–34·9]), high systolic blood pressure (6·7% [2·5–11·6]), lead exposure (6·5% [4·5–11·2]), and diet low in omega-6 polyunsaturated fatty acids (5·3% [0·5–10·5]). Interpretation: Stroke burden has increased from 1990 to 2021, and the contribution of several risk factors has also increased. Effective, accessible, and affordable measures to improve stroke surveillance, prevention (with the emphasis on blood pressure, lifestyle, and environmental factors), acute care, and rehabilitation need to be urgently implemented across all countries to reduce stroke burden. Funding: Bill & Melinda Gates Foundation.

DOI： 10.1016/S1474-4422(24)00369-7

高齢男性の疲労感は独立した非就労関連因子である愛知職域コホート研究

洪英在, 大塚礼, 高田碧, 李媛英, 宋澤安, 松永眞章, He Yupeng, 太田充彦, 玉腰浩司, 八谷寛

日本公衆衛生学会総会抄録集 83回巻頁： 277 - 277 2024年10月

Nonrestorative Sleep and Type 2 Diabetes Incidence: the Aichi Workers' Cohort Study 査読有り Open Access

Lin, JY; Song, Z; Li, YY; Chiang, CF; Hirakawa, Y; Nakano, Y; Hong, YJ; Matsunaga, M; Ota, A; Tamakoshi, K; Yatsuya, H

JOURNAL OF EPIDEMIOLOGY 34 巻 ( 9 ) 頁： 428 - 433 2024年9月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: The term “nonrestorative sleep (NRS)” refers to an unrefreshed feeling at wake-up and is a domain of poor sleep quality. Previous research has demonstrated that NRS is linked to a number of diseases and adverse health outcomes, but less is known regarding the link between NRS and diabetes, particularly in Japanese. Methods: We studied 3,665 middle-aged male participants of the Aichi Workers’ Cohort Study who were followed-up from 2002 through 2019. Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) of incident type 2 diabetes mellitus (T2DM) in relation to NRS adjusted for potential confounding variables. Results: During a median follow-up of 14.6 years, 421 type 2 diabetes cases were identified. Participants with NRS had a higher crude incidence rate of T2DM (11.2/1,000 person-years), compared to participants without NRS (9.3/1,000 person-years). In the fully adjusted model, individuals who reported having NRS had a significantly higher risk of developing T2DM (HR1.36; 95% CI, 1.10–1.67). The association was observed only in participants under 50 years old (HR 1.82; 95% CI, 1.36–2.43), not in the older (50 years or older) participants (P for interaction = 0.025). In contrast, stratified analyses by the presence of shift work, obesity, or sleep duration showed similar associations in all the strata. Conclusion: NRS was associated with higher risk of T2DM in middle-aged Japanese male workers independent of a variety of lifestyle factors and other sleep problems.

DOI： 10.2188/jea.JE20230184

Impact of diabetes on mortality and hospitalization after dementia diagnosis: Health insurance claims data analysis 査読有り

Matsunaga, M; Tanihara, S; He, YP; Yatsuya, H; Ota, A

GERIATRICS & GERONTOLOGY INTERNATIONAL 24 巻 ( 8 ) 頁： 773 - 781 2024年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Geriatrics and Gerontology International

Aim: Japan faces a public health challenge of dementia, further complicated by the increasing complications from diabetes within its rapidly aging population. This study assesses the impact of diabetes on mortality and hospitalization among individuals aged ≥75 years with new dementia diagnoses. Methods: We analyzed administrative claims data in Japan from 73 324 individuals aged ≥75 years with dementia, of whom 17% had comorbid diabetes. Dementia and diabetes were identified from the International Classification of Diseases, Tenth Revision codes. We used Kaplan–Meier survival analysis, Cox proportional hazards analysis, and population attributable fractions (PAFs) to evaluate the impact on mortality and hospitalization after dementia diagnosis. Results: One-year mortality and 1-year hospitalization probabilities in individuals with dementia and diabetes (10.3% and 31.7%, respectively) were higher than those without diabetes (8.3% and 25.4%, respectively). The adjusted hazard ratios for individuals with diabetes, as compared to those without, were 1.126 (95% confidence interval [CI], 1.040–1.220) for mortality and 1.191 (95% CI, 1.140–1.245) for hospitalization. The PAFs from the comorbidity of dementia and diabetes were 2.2% for mortality and 3.1% for hospitalization. Subgroup analysis showed that the PAFs were highest in men aged 75–79 years and women aged 80–84 years for mortality and in individuals aged 75–79 for hospitalization. Conclusion: During the early postdiagnosis period, comorbid diabetes increases mortality and hospitalization risks in older adults with dementia. The variation in disease burden across age groups underscores the need for age-specific health care strategies to manage comorbid diabetes in individuals with dementia. Geriatr Gerontol Int 2024; 24: 773–781.

DOI： 10.1111/ggi.14926

Efficacy of Immune Checkpoint Inhibitors in Postoperative Recurrence of Wild-type EGFR Non-Small Cell Lung Cancer 査読有り Open Access

Imamura, Y; Kato, T; Nomata, Y; Okado, S; Watanabe, H; Kawasumi, Y; Nakanishi, K; Kadomatsu, Y; Ueno, H; Nakamura, S; Mizuno, T; Hase, T; Tanaka, I; Ishii, M; Yatsuya, H; Chen-yoshikawa, TF

ANTICANCER RESEARCH 44 巻 ( 8 ) 頁： 3451 - 3461 2024年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Anticancer Research

Background/Aim: Immune checkpoint inhibitors (ICIs) have been widely used in the treatment of non-small cell lung cancer (NSCLC), but specific outcomes of ICIs treatment among patients with postoperative recurrence of NSCLC remain unclear. The objective of the study was to compare the efficacy of ICIs and chemotherapy with conventional chemotherapy only in patients with postoperative recurrence of epidermal growth factor receptor (EGFR) wild-type NSCLC. Patients and Methods: A retrospective analysis was performed on patients who underwent anatomical lung resection at the Nagoya University Hospital and were treated for postoperative recurrence of wild-type EGFR NSCLC. This study evaluated the prognosis for postoperative recurrence, including ICIs treatment and other clinicopathological factors. Results: Of the 83 patients included in the analysis, 20 patients underwent chemotherapy and 63 patients underwent chemotherapy combined with ICIs. The combination of ICIs and chemotherapy significantly prolonged survival after recurrence (median survival: 33.1 months vs. 22.0 months, p=0.01). In the ICIs group, no significant differences in survival were detected between patients with different programmed death ligand 1 (PD-L1) status (Tumor Proportion Scores: <1%, 1%-49%, ≥50%, p=0.27). Multivariate analysis revealed that postoperative distant recurrence was a significant poor prognostic factor for survival after recurrence (HR=1.85, 95% CI=1.06-3.25, p=0.03), and combining ICIs with chemotherapy significantly improved survival after recurrence (HR=0.43, 95% CI=0.24-0.78, p<0.01). Conclusion: Combination of ICIs with chemotherapy significantly prolonged survival of postoperative recurrence with wild-type EGFR NSCLC regardless of PD-L1 status.

DOI： 10.21873/anticanres.17165

Association between milk consumption in middle age and frailty in later life: The Aichi Workers' cohort study 査読有り Open Access

Hong, YJ; Otsuka, R; Song, Z; Fukuda, C; Tajima, R; Lin, JY; Hibino, M; Kobayashi, M; He, YP; Matsunaga, M; Ota, A; Nakano, Y; Li, YY; Tamakoshi, K; Yatsuya, H

GERIATRICS & GERONTOLOGY INTERNATIONAL 24 巻 ( 7 ) 頁： 700 - 705 2024年7月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Geriatrics and Gerontology International

Aim: Several studies have shown that dairy consumption in old age is effective in preventing frailty. However, there is a lack of evidence regarding the association between milk consumption during middle age and the development of frailty in old age. Therefore, we carried out an investigation to explore the association between milk consumption during middle age and development of frailty examined after over 15 years of follow up in a long-term cohort study in Japan. Methods: We studied 265 participants aged 60–79 years (212 men and 53 women) in 2018, who participated in both the baseline survey in 2002 and the frailty assessment in 2018. The amount of milk consumption (g/day) at baseline was age- and energy-adjusted, and classified into three categories (no, low and high consumption: 0 g/day, ≤135.86 g/day, >135.86 g/day in men and 0 g/day, ≤126.44 g/day, >126.44 g/day in women). Odds ratios (OR) and 95% confidence intervals (CI) for prefrailty/frailty after adjusting for lifestyles at baseline, stratified by sex, were estimated using logistic regression analysis. Results: The prevalence of prefrailty/frailty in 2018 was 37.7% and 28.3% in men and women, respectively. Milk consumption categories were inversely associated with the prevalence of prefrailty/frailty in men (OR 0.34, 95% CI 0.14–0.84 in low consumption; OR 0.31, 95% CI 0.10–0.95 in high consumption; P < 0.05), but not in women (OR 0.53, 95% CI 0.11–2.65; P = 0.44). Conclusions: In this study, milk intake in middle-aged men was inversely associated with the prevalence of prefrailty/frailty later in life. Geriatr Gerontol Int 2024; 24: 700–705.

DOI： 10.1111/ggi.14916

定年退職期の就労継続と脳灰白質容積の10年間の変化

大塚礼, 西田裕紀子, 丹下智香子, 八谷寛, 久保田彩, 安藤富士子, 下方浩史, 加藤隆司, 中村昭範, 荒井秀典

日本老年医学会雑誌 61 巻 ( Suppl. ) 頁： 141 - 141 2024年5月

20歳から老年期にかけての体重変動はフレイル発症関連要因である愛知職域コホート研究

洪英在, 大塚礼, 宋澤安, 福田知里, 小林芽生, 松永眞章, 太田充彦, 李媛英, 玉腰浩司, 八谷寛

日本老年医学会雑誌 61 巻 ( Suppl. ) 頁： 133 - 133 2024年5月

Relationship between size of pharyngeal and palatine tonsils and apnea-hypopnea index in pediatric obstructive sleep apnea. 査読有り

Kaneko M, Hirata M, Kimura A, Inada H, Shikano K, Ito S, Okano T, Yatsuya H, Nakata S

Fujita medical journal 10 巻 ( 2 ) 頁： 60 - 63 2024年5月

記述言語：英語出版者・発行元：Fujita Medical Journal

Objective: To determine whether the combination of the pharyngeal tonsil grade and palatine tonsil grade results in differences in the apnea–hypopnea index (AHI) and to determine whether each parameter separately (pharyngeal tonsil grade and palatine tonsil grade) results in differences in severe obstructive sleep apnea (OSA). Methods: This cross-sectional study involved 107 children (mean age, 7.2 years; range, 4–12 years) suspected of having OSA because of snoring or sleep-related complaints. The patients underwent polysomnography, and their palatine and pharyngeal tonsils were graded. Results: In examining whether the palatine tonsils and pharyngeal tonsils could be risk factors for severe OSA, the adjusted odds ratios were 4.42 for palatine tonsil grade 4 versus 1–3 and 10.40 for pharyngeal tonsil grade 4 versus 1–3; both were highly statistically significant. We also found that the AHI when both the pharyngeal and palatine tonsils were grade 4 was higher than the AHI expected for the pharyngeal and palatine tonsils alone. Conclusions: The combination of grade 4 pharyngeal tonsils and grade 4 palatine tonsils resulted in an AHI much higher than the AHI of other combinations (pharyngeal tonsils grades 1–3 and 4, palatine tonsils grades 1–3 and 4). We believe that grade 4 pharyngeal tonsils and grade 4 palatine tonsils have a great influence on severe OSA and that grade 4 pharyngeal tonsils increase the AHI.

DOI： 10.20407/fmj.2023-011

Anti-Factor Xa Activity in Patients With Chronic Thromboembolic Pulmonary Disease With or Without Pulmonary Hypertension Treated With Factor Xa Inhibitors

日本人中年男性における長期的な収縮期血圧変動とうつ状態発症との関連

小林芽生, 李媛英, 宋澤安, 洪英在, 日比野瑞歩, 田島里菜, 太田充彦, 大塚礼, 玉腰浩司, 八谷寛

日本循環器病予防学会誌 59 巻 ( 2 ) 頁： 127 - 127 2024年4月

鈴木貞夫, 尾島俊之, 永田知里, 八谷寛, 若井建志

東海公衆衛生雑誌 11 巻 ( 2 ) 頁： 143 - 144 2024年3月

Associations of overweight and obesity with the risk of cardiovascular disease according to metabolic risk factors among middle-aged Japanese workers: The Aichi Workers' cohort study 査読有り国際共著 Open Access

Al-shoaibi, AAA; Li, YY; Chiang, CF; Nakano, Y; Hirakawa, Y; Matsunaga, M; Ota, A; Tamakoshi, K; Yatsuya, H

OBESITY RESEARCH & CLINICAL PRACTICE 18 巻 ( 2 ) 頁： 101 - 108 2024年3月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Obesity Research and Clinical Practice

Background: The association between obesity and cardiovascular disease (CVD) remains unclear, particularly for those with established CVD risk factors. We analyzed follow-up data from the Aichi Workers’ Cohort Study. We studied the association between the degree of obesity and risk of CVD and its subtypes specifically among individuals with hypertension, hyper-low-density lipoprotein (LDL)-cholesterolemia, or diabetes. Methods: Pooled data of 8972 adults (7076 men and 1896 women) who were recruited between 2002 and 2008 were used in the current analysis. We used multivariable Cox proportional hazard model to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between the degree of obesity assessed with body mass index (BMI) and the risk of CVD and its subtypes, i.e., coronary heart disease (CHD) and stroke. Results: During a median of 12 years, there were 197 CVDs (80 CHDs and 117 strokes). BMI ≥ 27.5 compared to 21.0–22.9 kg/m2 was positively and significantly associated with the risks of CVD, CHD, and total stroke. Hypertension, hyper-LDL-cholesterolemia, and diabetes mediated 15.9%, 5.8%, and 8.7% of obesity-CVD associations, respectively, and 28.3% by their combination. In the stratified analyses by the presence of risk factors, BMI ≥ 25.0 (overweight/obesity) compared to BMI < 25 kg/m2 was associated with a higher risk of CVD in those with and without hypertension, but only with hyper-LDL-cholesterolemia, and without diabetes. Conclusions: Overweight/obesity was associated with the risk of CVD and its subtypes. About 30% of the risk was explained by hypertension, hyper-LDL-cholesterolemia, and diabetes, of which hypertension accounted for approximately the half of the explained risk. However, overweight/obesity increased the risk of CVD even in those without hypertension. These findings highlight the importance of controlling and preventing overweight/obesity regardless of chronic disease status.

DOI： 10.1016/j.orcp.2024.02.006

Prediction model of the risk for lateral local recurrence in locally advanced rectal cancer without enlarged lateral lymph nodes: Lessons from a Japanese multicenter pooled analysis of 812 patients 査読有り Open Access

Ogura, A; Shiomi, A; Yamamoto, S; Komori, K; Hamamoto, H; Manabe, S; Miyakita, H; Okuda, J; Yatsuya, H; Uehara, K

ANNALS OF GASTROENTEROLOGICAL SURGERY 8 巻 ( 2 ) 頁： 284 - 292 2024年3月

記述言語：英語出版者・発行元：Annals of Gastroenterological Surgery

Aim: Although the oncological impact of lateral lymph node dissection on enlarged lateral lymph nodes has been gradually accepted over the last decade, that on lateral lymph nodes without swelling remains doubtful. This study aimed to develop a prediction model for the future risk of lateral local recurrence and to clarify the value of adding lateral lymph node dissection in locally advanced rectal cancer without enlarged lateral lymph nodes. Methods: This retrospective, multi-institutional study recruited 812 patients with cStage II/III low rectal cancer without enlarged lateral lymph nodes <7 mm. Total lateral local recurrence was a hypothetical value of future risk of lateral local recurrence when lateral lymph node dissection was never performed. Results: Overall, total lateral local recurrences were observed in 67 patients (8.3%). In the multivariate analyses, the strongest risk factor for total local recurrences was no preoperative chemoradiotherapy (odds ratio [OR][95%Cl]: 33.2 [4.56–241.7], P < 0.001), followed by tumor distance ≤40 mm (OR [95%Cl]: 2.71 [1.51–4.86], P < 0.001) and lateral lymph node 5–7 mm (OR[95%Cl]: 2.38 [1.26–4.48], P = 0.007). In patients with lateral lymph nodes of 5–7 mm, the total lateral recurrence rate was 4.8% after preoperative chemoradiotherapy. Lateral lymph node dissection could reduce from a total lateral local recurrence of 21.6% to an actual lateral local recurrence of 8.0% in patients without preoperative treatment. Conclusion: We introduce a novel prediction model of future risk of lateral local recurrences, which has the potential to enable us to indicate lateral lymph node dissection selectively according to the patients' risks.

DOI： 10.1002/ags3.12742

The effect of age on the relationship between body mass index and risks of incident stroke subtypes: The JPHC study 査読有り国際誌 Open Access

Nuamah, HG; Li, YY; Yatsuya, H; Yamagishi, K; Saito, I; Kokubo, Y; Muraki, I; Iso, H; Inoue, M; Tsugane, S; Sawada, N

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 33 巻 ( 2 ) 頁： 107486 - 107486 2024年2月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Stroke and Cerebrovascular Diseases

Objective: The associations between body mass index (BMI) and stroke subtypes, particularly intracerebral hemorrhage, have not been consistent. Such inconsistencies may be due to differences in the age at which BMI was obtained. We examined the possible age modifications in the association between BMI and stroke risk. Materials and Methods: We followed 88,754 participants, aged 40–69 years at baseline (1990-1994), of the Japan Public Health Center-based prospective (JPHC) study for stroke incidence. BMI was obtained using self-reported body weight and height, which were categorized using the following cut-off points: 18.5, 21, 23, 25, 27.5, and 30 kg/m2. Time-dependent Cox proportional hazards models that updated BMI and covariates using 5- and 10-year questionnaire responses were used to estimate hazard ratios and 95 % confidence intervals. The analyses were stratified by age group (40–59 and ≥60 years) and the age of the individuals was updated. Results: During the median follow-up period of 19 years, we documented 4,690 strokes, including 2,781 ischemic strokes and 1,358 intracerebral hemorrhages. After adjusting for sex, age, smoking, alcohol consumption, leisure-time physical activity, history of hypertension, dyslipidemia, and diabetes mellitus, we observed a positive linear association between BMI and ischemic stroke (linear trend, p < 0.001) in both age groups (interaction p>0.05). In contrast, a curvilinear association between BMI and intracerebral hemorrhage was observed in both the middle (curvilinear trend, p=0.017) and the older group (curvilinear trend, p=0.098) (interaction p>0.05). Conclusion: BMI and stroke associations did not vary significantly with age, although the association may differ according to subtype.

DOI： 10.1016/j.jstrokecerebrovasdis.2023.107486

Nakano, Y; Adachi, S; Kondo, H; Hirose, M; Adachi, T; Nishiyama, I; Yasuda, K; Yoshida, M; Yatsuya, H; Murohara, T

CIRCULATION 148 巻 2023年11月

肥満疫学研究の最前線高齢期の身体指標の加齢変化と要介護予防

大塚礼, 八谷寛

肥満研究 29 巻 ( 合同学術集会抄録集 ) 頁： 131 - 131 2023年11月

The electrophysiological index can effectively predict subsequent coronary artery aneurysm in children with Kawasaki disease. 査読有り国際誌

Suzuki D, Suzuki T, Fujino M, Asai Y, Kojima A, Uchida H, Saito K, Kusuki H, Li Y, Yatsuya H, Sadanaga T, Hata T, Yoshikawa T

Fujita medical journal 9 巻 ( 4 ) 頁： 275 - 281 2023年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Fujita Medical Journal

Objectives: The Gunma score is used to predict the severity of Kawasaki disease (KD), including coronary artery aneurysm (CAA) as a cardiac complication, in Japan. Additionally, the characteristic ratio of ventricular repolarization (T-peak to T-end interval to QT interval [Tp-e/QT]) on a surface electrocardiogram reflects myocardial inflammation. This study aimed to determine whether the Tp-e/QT can be used to predict CAA in children with KD. Methods: We analyzed chest surface electrocardiograms of 112 children with KD before receiving intravenous immunoglobulin therapy using available software (QTD; Fukuda Denshi, Tokyo, Japan). Results: The Tp-e/QT (lead V5) was positively correlated with the Gunma score (r=0.352, p<0.001). The Tp-e/QT was larger in patients with CAA (residual CAA at 1 month after onset) than in those without CAA (0.314±0.026 versus 0.253±0.044, p=0.003). A receiver operating characteristic curve analysis was performed to assess whether the Gunma score and Tp-e/QT could predict subsequent CAA. The area under the curve of the Gunma score was 0.719 with the cutoff set at 5 points. The area under the curve of the Tp-e/QT was 0.892 with a cutoff value of 0.299. The fit of the prediction models to the observed probability was tested by the Hosmer–Lemeshow test with calibration plots using Locally weighted scatterplot smoothing (LOESS) fit. The Gunma score (p=0.95) and Tp-e/QT (p=0.95) showed a good fit. Conclusions: The Tp-e/QT is a useful biomarker in predicting coronary aneurysm complications in KD.

DOI： 10.20407/fmj.2023-001

Applicability of a Web-based 24-hour Dietary Recall Tool for Japanese Populations in Large-scale Epidemiological Studies Open Access

Association of psychological factors with advanced-level functional competency: Findings from the Aichi workers' cohort study, 2002-2019 査読有り国際共著 Open Access

Saif-Ur-Rahman, K; Hong, YJ; Li, YY; Matsunaga, M; Song, Z; Shimoda, M; Al-Shoaibi, A; He, YP; Mamun, MR; Hirano, Y; Chiang, CF; Hirakawa, Y; Aoyama, A; Tamakoshi, K; Ota, A; Otsuka, R; Yatsuya, H

HELIYON 9 巻 ( 11 ) 頁： e21931 - e21931 2023年11月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Heliyon

Objective: This study examined the longitudinal association of perceived stress, ikigai, and having someone one can count on in middle age with the advanced-level functional competency in older age, which is crucial for the maintenance of independent life among older adults. The issue is especially relevant in super-aged countries like contemporary Japan, where more and more older people live in a household consisting only of older people. Methods: Data were collected in 2019 from a total of 1692 retirees of the Aichi Workers’ Cohort Study participants in which baseline survey including psychological factors was conducted during their employment in 2002. Japan Science and Technology Agency Index of Competence (JST-IC) was used to measure the advanced-level functional competency. Multivariable-adjusted odds ratios (ORs) were obtained for having low JST-IC in later life by the degrees of psychological factors reported in the middle age adjusting for the presence of depressive mood in 2019. Results: Those who were not sure about ikigai (OR: 2.02, 95 % CI: 1.33 to 3.08) and who have no one to count on (OR: 2.19, 95 % CI: 1.52 to 3.16) in the middle age were significantly associated with low JST-IC after retirement. Having much stress was significantly inversely associated with a low JST-IC (OR: 0.69, 95 % CI: 0.50 to 0.97). Conclusion: Having ikigai and someone reliable, and stress during middle age might play a role in preventing impaired advanced-level functional competency. Improved ikigai and increased social interaction and support might improve functional competency. Further research might explore avenues for improving ikigai.

DOI： 10.1016/j.heliyon.2023.e21931

Good death for people living with dementia: a qualitative study 査読有り Open Access

Mamun, MR; Hirakawa, Y; Saif-Ur-Rahman, KM; Hong, YJ; Song, Z; Yoshida, Y; Yatsuya, H

BMC GERIATRICS 23 巻 ( 1 ) 頁： 665 2023年10月

記述言語：英語出版者・発行元：BMC Geriatrics

Background: Ensuring a good death is one of the primary objectives of palliative care and end-of-life care. There is insufficient evidence regarding what defines a good death for people living with dementia. Obtaining an understanding of what constitutes a good death could help improve dementia care. This study aimed to explore how multiple stakeholders perceive a good death for people living with dementia. Methods: This qualitative study was carried out across six prefectures in Japan. Enrollment of participants took place within dementia outpatient clinics, hospitals, daycare centers, and community centers. A total of thirty-three in-depth interviews with people living with dementia, physicians, and nurses were conducted. Six focus group discussions were performed with family caregivers and care workers. Verbatim transcripts of the interviews were prepared, and inductive content analysis was used to examine the data. Findings: Regarding the perception of a good death, the following themes were derived: (1) painless death; (2) dying in a preferred environment; (3) family’s coping with loss; (4) maintaining regular life; (5) living with respect; and (6) preparation for death. All these themes are interrelated. Participants viewed a good death as a process rather than a single event. Conclusion: This study identifies crucial components of a good death for people living with dementia. The findings could be used to improve dementia care.

DOI： 10.1186/s12877-023-04395-y

Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes An Individual-Participant Data Meta-Analysis 査読有り国際共著国際誌 Open Access

Grams, ME; Coresh, J; Matsushita, K; Ballew, SH; Sang, YY; Surapaneni, A; de Pinho, NA; Anderson, A; Appel, LJ; Ärnlöv, J; Azizi, F; Bansal, N; Bell, S; Bilo, HJG; Brunskill, NJ; Carrero, JJ; Chadban, S; Chalmers, J; Chen, J; Ciemins, E; Cirillo, M; Ebert, N; Evans, M; Ferreiro, A; Fu, EL; Fukagawa, M; Green, JA; Gutierrez, OM; Herrington, WG; Hwang, SJ; Inker, LA; Iseki, K; Jafar, T; Jassal, SK; Jha, V; Kadota, A; Katz, R; Köttgen, A; Konta, T; Kronenberg, F; Lee, BJ; Lees, J; Levin, A; Looker, HC; Major, R; Cohen, CM; Mieno, M; Miyazaki, M; Moranne, O; Muraki, I; Naimark, D; Nitsch, D; Oh, W; Pena, M; Purnell, TS; Sabanayagam, C; Satoh, M; Sawhney, S; Schaeffner, E; Schöttker, B; Shen, JI; Shlipak, MG; Sinha, S; Stengel, B; Sumida, K; Tonelli, M; Valdivielso, JM; van Zuilen, AD; Visseren, FLJ; Wang, AYM; Wen, CP; Wheeler, DC; Yatsuya, H; Yamagata, K; Yang, JW; Young, A; Zhang, HT; Zhang, L; Levey, AS; Gansevoort, RT

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 330 巻 ( 13 ) 頁： 1266 - 1277 2023年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAMA

Importance: Chronic kidney disease (low estimated glomerular filtration rate [eGFR] or albuminuria) affects approximately 14% of adults in the US. Objective: To evaluate associations of lower eGFR based on creatinine alone, lower eGFR based on creatinine combined with cystatin C, and more severe albuminuria with adverse kidney outcomes, cardiovascular outcomes, and other health outcomes. Design, Setting, and Participants: Individual-participant data meta-analysis of 27503140 individuals from 114 global cohorts (eGFR based on creatinine alone) and 720736 individuals from 20 cohorts (eGFR based on creatinine and cystatin C) and 9067753 individuals from 114 cohorts (albuminuria) from 1980 to 2021. Exposures: The Chronic Kidney Disease Epidemiology Collaboration 2021 equations for eGFR based on creatinine alone and eGFR based on creatinine and cystatin C; and albuminuria estimated as urine albumin to creatinine ratio (UACR). Main Outcomes and Measures: The risk of kidney failure requiring replacement therapy, all-cause mortality, cardiovascular mortality, acute kidney injury, any hospitalization, coronary heart disease, stroke, heart failure, atrial fibrillation, and peripheral artery disease. The analyses were performed within each cohort and summarized with random-effects meta-analyses. Results: Within the population using eGFR based on creatinine alone (mean age, 54 years [SD, 17 years]; 51% were women; mean follow-up time, 4.8 years [SD, 3.3 years]), the mean eGFR was 90 mL/min/1.73 m2(SD, 22 mL/min/1.73 m2) and the median UACR was 11 mg/g (IQR, 8-16 mg/g). Within the population using eGFR based on creatinine and cystatin C (mean age, 59 years [SD, 12 years]; 53% were women; mean follow-up time, 10.8 years [SD, 4.1 years]), the mean eGFR was 88 mL/min/1.73 m2(SD, 22 mL/min/1.73 m2) and the median UACR was 9 mg/g (IQR, 6-18 mg/g). Lower eGFR (whether based on creatinine alone or based on creatinine and cystatin C) and higher UACR were each significantly associated with higher risk for each of the 10 adverse outcomes, including those in the mildest categories of chronic kidney disease. For example, among people with a UACR less than 10 mg/g, an eGFR of 45 to 59 mL/min/1.73 m2based on creatinine alone was associated with significantly higher hospitalization rates compared with an eGFR of 90 to 104 mL/min/1.73 m2(adjusted hazard ratio, 1.3 [95% CI, 1.2-1.3]; 161 vs 79 events per 1000 person-years; excess absolute risk, 22 events per 1000 person-years [95% CI, 19-25 events per 1000 person-years]). Conclusions and Relevance: In this retrospective analysis of 114 cohorts, lower eGFR based on creatinine alone, lower eGFR based on creatinine and cystatin C, and more severe UACR were each associated with increased rates of 10 adverse outcomes, including adverse kidney outcomes, cardiovascular diseases, and hospitalizations.

DOI： 10.1001/jama.2023.17002

孤食は、世帯構成や孤独感とは独立した抑うつ関連因子である愛知職域コホート研究

洪英在, 大塚礼, 平川仁尚, 太田充彦, 玉腰浩司, 八谷寛

日本公衆衛生学会総会抄録集 82回巻頁： 286 - 286 2023年10月

Hose, Y; Ishihara, J; Kotemori, A; Nakadate, M; Maruya, S; Tanaka, J; Yatsuya, H; Aoyama, A; Chiang, CF; Konta, T; Kayama, T; Ueno, Y; Inoue, M; Sawada, N; Tsugane, S; Takachi, R

JOURNAL OF EPIDEMIOLOGY 33 巻 ( 8 ) 頁： 419 - 427 2023年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: Recent innovations in information and communication technology have made it possible to assess diet using web-based methods; however, their applicability in the general population remains unclear. Hence, we aimed to examine the applicability of a web-based 24-hour dietary recall (24HR) tool to large-scale epidemiological studies by determining the sampling rate and characteristics of randomly selected participants from a Japanese cohort study. Methods: In total, 5,013 individuals were recruited from a cohort of 21,537 individuals, and 975 agreed to participate in this study. The participants selected either self-administered web-based dietary 24HR (self-administered 24HR) or interviewer-administered telephone-based 24HR (interviewer-administered 24HR) as the method for the dietary assessment and answered questions regarding the acceptability of the system. Results: The response rate of the 975 participants was 19.4%, corresponding to approximately 4.5% of the total study sample. About half of them chose the self-administered 24HR (46.9%). The median time required for the self-administered and interviewer-administered 24HR was 25 and 27 minutes, respectively. In the self-administered 24HR, older people, regardless of sex, tended to require a longer time, and approximately 60% of the participants rated the ease of use of the system as “somewhat difficult” or “difficult.” Conclusion: Characteristics of the participants in this study were not systemically different from those of the entire study sample. Improvements in the approach to entering cooking details and the dish name selection may be necessary for better acceptability in order to be accepted as a self-administered dietary recall tool.

DOI： 10.2188/jea.JE20220071

Impact of Cardiovascular Disease on the Death Certificate Diagnosis of Heart Failure, Ischemic Heart Disease, and Cerebrovascular Disease ? The Japan Public Health Center-Based Prospective Study ? 査読有り Open Access

Saito, I; Yamagishi, K; Kokubo, Y; Yatsuya, H; Iso, H; Sawada, N; Inoue, M; Tsugane, S

CIRCULATION JOURNAL 87 巻 ( 9 ) 頁： 1196 - + 2023年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Circulation Journal

Background: There is considerable interest in the trending discrepancy between ischemic heart disease (IHD) and heart failure (HF) in vital statistics. Clinically, acute myocardial infarction (AMI) and stroke are closely associated with HF, but their contribution to HF as the underlying cause of death (UCD) is unclear. Methods and Results: In 1990 and 1992–1993, we enrolled a total of 140,420 residents of Japanese nationality (aged 40–69 years) from 11 public health center areas. We prospectively examined the occurrence of cardiovascular disease (CVD), including AMI, sudden cardiac death within 1 h (SCD), and stroke, and analyzed the 14,375 participants without a history of CVD at baseline who died during the 20-year follow-up. A time-dependent Cox proportional hazards model was used to estimate hazard ratios and the population attributable fraction (PAF) of AMI, AMI+SCD, stroke, and CVD for deaths due to HF, IHD, and cerebrovascular disease as the UCD, adjusted for individuals’ lifestyles and comorbid conditions. The PAF of AMI for HF deaths was 2.4% (95% confidence interval [CI] 1.7–2.9%), which increased to 12.0% (95% CI 11.6–12.2%) for AMI+SCD. The PAF of CVD-attributed HF deaths was estimated to be 17.6% (95% CI 15.9–18.9%). Conclusions: HF as the UCD was partly explained by CVD. The data imply that most HF deaths reported in vital statistics may be associated with underlying causes other than CVD.

DOI： 10.1253/circj.CJ-22-0805

Associations between changes in social contact pattern and the mental health status of Chinese adults: cross-sectional findings 査読有り国際共著 Open Access

Zhang, JY; Zhou, S; Wang, Q; Hou, FF; Han, X; Shen, GD; Chiang, CF; Yatsuya, H; Zhang, Y

NAGOYA JOURNAL OF MEDICAL SCIENCE 85 巻 ( 3 ) 頁： 476 - 489 2023年8月

記述言語：英語出版者・発行元：Nagoya Journal of Medical Science

The study aims to examine the associations between social contact pattern changes and mental health status, including depression, anxiety, and loneliness, among Chinese adults in the context of coronavirus disease 2019 (COVID-19). Data on social contact patterns before and after the outbreak of COVID-19 were obtained from 3511 participants. Mental health (ie, depression, anxiety, and loneliness) was assessed by the 9-item Patient Health Questionnaire, Dark Future Scale, and the 9-scale Three-Item Loneliness Scale, respectively. Poisson regression analyses revealed that the participants who had increased in-person communication were more likely to have mental disorders [depression: prevalence ratio (PR)=1.13, 95% confidence interval (CI): 1.02, 1.26; anxiety: PR=1.15, 95% CI: 1.01, 1.30]. The current study concluded that the in-person communication increase before and after the outbreak of COVID-19 was associated with mental disorders among Chinese adults.

DOI： 10.18999/nagjms.85.3.476

Risk and population attributable fraction of stroke subtypes in Japan 査読有り Open Access

Yatsuya, H; Yamagishi, K; Li, YY; Saito, I; Kokubo, Y; Muraki, I; Inoue, M; Tsugane, S; Iso, H; Sawada, N

JOURNAL OF EPIDEMIOLOGY 34 巻 ( 5 ) 頁： 211 - 217 2023年7月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: Associations of major risk factors for stroke with total and each type of stroke, as well as subtypes of ischemic stroke, and their population attributable fractions had not been examined comprehensively. Methods: Participants of the Japan Public Health Center-based prospective (JPHC) Study Cohort II without histories of cardiovascular disease and cancer (n = 14,797) were followed from 1993 through 2012. Associations of current smoking, hypertension, diabetes, overweight (body mass index ≥25 kg/m2), non-high-density lipoprotein cholesterol (non-HDLC) categories, low HDLC (<40 mg/dL), urine protein, and history of arrhythmia were examined in a mutually-adjusted Cox regression model that included age and sex. Population attributable fractions (PAFs) were estimated using the hazard ratios and the prevalence of risk factors among cases. Results: Subjects with hypertension were 1.63 to 1.84 times more likely to develop any type of stroke. Diabetes, low HDLC, current smoking, overweight, urine protein, and arrhythmia were associated with risk of overall and ischemic stroke. Hypertension and urine protein were associated with risk of intracerebral hemorrhage, while current smoking, hypertension, and low non-HDLC were associated with subarachnoid hemorrhage. Hypertension alone accounted for more than a quarter of stroke incidence, followed by current smoking and diabetes. High non-HDLC, current smoking, low HDLC, and overweight contributed mostly to large-artery occlusive stroke. Arrhythmia explained 13.2% of embolic stroke. Combined PAFs of all the modifiable risk factors for total, ischemic, and large-artery occlusive strokes were 36.7%, 44.5%, and 61.5%, respectively. Conclusion: Although there are differences according to subtypes, hypertension could be regarded as the most crucial target for preventing strokes in Japan.

DOI： 10.2188/jea.JE20220364

Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021 Open Access

Ong, KL; Stafford, LK; Mclaughlin, SA; Boyko, EJ; Vollset, SE; Smith, AE; Dalton, BE; Duprey, J; Cruz, JA; Hagins, H; Lindstedt, PA; Aali, A; Abate, YH; Abate, MD; Abbasian, M; Abbasi-Kangevari, Z; Abbasi-Kangevari, M; Abd ElHafeez, S; Abd-Rabu, R; Abdulah, DM; Abdullah, AM; Abedi, V; Abidi, H; Aboagye, RG; Abolhassani, H; Abu-Gharbieh, E; Abu-Zaid, A; Adane, TD; Adane, DE; Addo, IY; Adegboye, OA; Adekanmbi, V; Adepoju, AV; Adnani, QES; Afolabi, RF; Agarwal, G; Aghdam, ZB; Agudelo-Botero, M; Arriagada, CEA; Agyemang-Duah, W; Ahinkorah, BO; Ahmad, D; Ahmad, R; Ahmad, S; Ahmad, A; Ahmadi, A; Ahmadi, K; Ahmed, A; Ahmed, A; Ahmed, LA; Ahmed, SA; Ajami, M; Akinyemi, RO; Al Hamad, H; Hasan, SMA; AL-Ahdal, TMA; Alalwan, TA; Al-Aly, Z; Albataineh, M; Alcalde-Rabanal, JE; Alemi, S; Ali, H; Alinia, T; Aljunid, SM; Almustanyir, S; Al-Raddadi, RM; Alvis-Guzman, N; Amare, F; Ameyaw, EK; Amiri, S; Amusa, GA; Andrei, CL; Anjana, RM; Ansar, A; Ansari, G; Ansari-Moghaddam, A; Anyasodor, AE; Arabloo, J; Aravkin, AY; Areda, D; Arifin, H; Arkew, M; Armocida, B; Aernloev, J; Artamonov, AA; Arulappan, J; Aruleba, RT; Arumugam, A; Aryan, Z; Asemu, MT; Asghari-Jafarabadi, M; Askari, E; Asmelash, D; Astell-Burt, T; Athar, M; Athari, SS; Atout, MMW; Avila-Burgos, L; Awaisu, A; Azadnajafabad, S; Darshan, BB; Babamohamadi, H; Badar, M; Badawi, A; Badiye, A; Baghcheghi, N; Bagheri, N; Bagherieh, S; Bah, S; Bahadory, S; Bai, RH; Baig, AA; Baltatu, OC; Baradaran, HR; Barchitta, M; Bardhan, M; Barengo, NC; Baernighausen, TW; Barone, MTU; Barone-Adesi, F; Barrow, A; Bashiri, H; Basiru, A; Basu, S; Basu, S; Batiha, AMM; Batra, K; Bayih, MT; Bayileyegn, NS; Behnoush, AH; Bekele, AB; Belete, MA; Belgaumi, UI; Belo, L; Bennett, DA; Bensenor, IM; Berhe, K; Berhie, AY; Bhaskar, S; Bhat, AN; Bhatti, JS; Bikbov, B; Bilal, F; Bintoro, BS; Bitaraf, S; Bitra, VR; Bjegovic-Mikanovic, V; Bodolica, V; Boloor, A; Brauer, M; Brazo-Sayavera, J; Brenner, H; Butt, ZA; Calina, D; Campos, LA; Campos-Nonato, IR; Cao, Y; 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Esayas, HL; Eshetu, HB; Etaee, F; Fadhil, I; Fagbamigbe, AF; Fahim, A; Falahi, S; Faris, MEM; Farrokhpour, H; Farzadfar, F; Fatehizadeh, A; Fazli, G; Feng, XQ; Ferede, TY; Fischer, F; Flood, D; Forouhari, A; Foroumadi, R; Koudehi, MF; Gaidhane, AM; Gaihre, S; Gaipov, A; Galali, Y; Ganesan, B; Garcia-Gordillo, MA; Gautam, RK; Gebrehiwot, M; Gebrekidan, KG; Gebremeskel, TG; Getacher, L; Ghadirian, F; Ghamari, SH; Nour, MG; Ghassemi, F; Golechha, M; Goleij, P; Golinelli, D; Gopalani, SV; Guadie, HA; Guan, SY; Gudayu, TW; Guimaraes, RA; Guled, RA; Gupta, R; Gupta, K; Gupta, VB; Gupta, VK; Gyawali, B; Haddadi, R; Hadi, NR; Haile, TG; Hajibeygi, R; Haj-Mirzaian, A; Halwani, R; Hamidi, S; Hankey, GJ; Hannan, MA; Haque, S; Harandi, H; Harlianto, N; Hasan, SMM; Hasan, S; Hasani, H; Hassanipour, S; Hassen, MB; Haubold, J; Hayat, K; Heidari, G; Heidari, M; Hessami, K; Hiraike, Y; Holla, R; Hossain, S; Hossain, MS; Hosseini, MS; Hosseinzadeh, M; Hosseinzadeh, H; Huang, JJ; Huda, N; Hussain, S; Huynh, HH; Hwang, BF; Ibitoye, SE; Ikeda, N; Ilic, IM; Ilic, M; Inbaraj, LR; Iqbal, A; Islam, SMS; Islam, RM; Ismail, NE; Iso, H; Isola, G; Itumalla, R; Iwagami, M; Iwu, CCD; Iyamu, IO; Iyasu, AN; Jacob, L; Jafarzadeh, A; Jahrami, H; Jain, R; Jaja, C; Jamalpoor, Z; Jamshidi, E; Janakiraman, B; Jayanna, K; Jayapal, SK; Jayaram, S; Jayawardena, R; Jebai, R; Jeong, W; Jin, YZ; Jokar, M; Jonas, JB; Joseph, N; Joseph, A; Joshua, CE; Joukar, F; Jozwiak, JJ; Kaambwa, B; Kabir, A; Kabthymer, RH; Kadashetti, V; Kahe, F; Kalhor, R; Kandel, H; Karanth, S; Karaye, IM; Karkhah, S; Katoto, PD; Kaur, N; Kazemian, S; Kebede, SA; Khader, YS; Khajuria, H; Khalaji, A; AB Khan, M; Khan, M; Khan, A; Khanal, S; Khatatbeh, MM; Khater, AM; Khateri, S; Khorashadizadeh, F; Khubchandani, J; Kibret, BG; Kim, MS; Kimokoti, RW; Kisa, A; Kivimaki, M; Kolahi, AA; Komaki, S; Kompani, F; Koohestani, HR; Korzh, O; Kostev, K; Kothari, N; Koyanagi, A; Krishan, K; Krishnamoorthy, Y; Defo, BK; Kuddus, M; Kuddus, MA; Kumar, R; Kumar, H; Kundu, S; Kurniasari, MD; Kuttikkattu, A; La Vecchia, C; Lallukka, T; Larijani, B; Larsson, AO; Latief, K; Lawal, BK; Le, TTT; Le, TTB; Lee, SWH; Lee, M; Lee, WC; Lee, PH; Lee, SW; Lee, SW; Legesse, SM; Lenzi, J; Li, YZ; Li, MC; Lim, SS; Lim, LL; Liu, XF; Liu, CJ; Lo, CH; Lopes, G; Lorkowski, S; Lozano, R; Lucchetti, G; Maghazachi, AA; Mahasha, PW; Mahjoub, S; Mahmoud, MA; Mahmoudi, R; Mahmoudimanesh, M; Mai, AT; Majeed, A; Sanaye, PM; Makris, KC; Malhotra, K; Malik, AA; Malik, I; Mallhi, TH; Malta, DC; Mamun, AA; Mansouri, B; Marateb, HR; Mardi, P; Martini, S; Martorell, M; Marzo, RR; Masoudi, R; Masoudi, S; Mathews, E; Maugeri, A; Mazzaglia, G; Mekonnen, T; Meshkat, M; Mestrovic, T; Jonasson, JM; Miazgowski, T; Michalek, IM; Minh, LHN; Mini, GK; Miranda, JJ; Mirfakhraie, R; Mirrakhimov, EM; Mirza-Aghazadeh-Attari, M; Misganaw, A; Misgina, KH; Mishra, M; Moazen, B; Mohamed, NS; Mohammadi, E; Mohammadi, M; Mohammadian-Hafshejani, A; Mohammadshahi, M; Mohseni, A; Mojiri-Forushani, H; Mokdad, AH; Momtazmanesh, S; Monasta, L; Moniruzzaman, M; Mons, U; Montazeri, F; Ghalibaf, AM; Moradi, Y; Moradi, M; Sarabi, MM; Morovatdar, N; Morrison, SD; Morze, J; Mossialos, E; Mostafavi, E; Mueller, UO; Mulita, F; Mulita, A; Murillo-Zamora, E; Musa, KI; Mwita, JC; Nagaraju, SP; Naghavi, M; Nainu, F; Nair, TS; Najmuldeen, HHR; Nangia, V; Nargus, S; Naser, AY; Nassereldine, H; Natto, ZS; Nauman, J; Nayak, BP; Ndejjo, R; Negash, H; Negoi, RI; Nguyen, HTH; Nguyen, DH; Nguyen, PT; Nguyen, VT; Nguyen, HQ; Niazi, RK; Nigatu, YT; Ningrum, DNA; Nizam, MA; Nnyanzi, LA; Noreen, M; Noubiap, JJ; Nzoputam, OJ; Nzoputam, CI; Oancea, B; Odogwu, NM; Odukoya, OO; Ojha, VA; Okati-Aliabad, H; Okekunle, AP; Okonji, OC; Okwute, PG; Olufadewa, II; Onwujekwe, OE; Ordak, M; Ortiz, A; Osuagwu, UL; Oulhaj, A; Owolabi, MO; Padron-Monedero, A; Padubidri, JR; Palladino, R; Panagiotakos, D; Panda-Jonas, S; Pandey, A; Pandey, A; Pandi-Perumal, SR; Stoian, AMP; Pardhan, S; Parekh, T; Parekh, U; Pasovic, M; Patel, J; Patel, JR; Paudel, U; Pepito, VCF; Pereira, M; Perico, N; Perna, S; Petcu, IR; Petermann-Rocha, FE; Podder, V; Postma, MJ; Pourali, G; Pourtaheri, N; Prates, EJS; Qadir, MMF; Qattea, I; Raee, P; Rafique, I; Rahimi, M; Rahimifard, M; Rahimi-Movaghar, V; Rahman, MO; Rahman, MA; Rahman, MHU; Rahman, M; Rahman, MM; Rahmani, M; Rahmani, S; Rahmanian, V; Rahmawaty, S; Rahnavard, N; Rajbhandari, B; Ram, P; Ramazanu, S; Rana, J; Rancic, N; Ranjha, MMAN; Rao, CR; Rapaka, D; Rasali, DP; Rashedi, S; Rashedi, V; Rashid, AM; Rashidi, MM; Ratan, ZA; Rawaf, S; Rawal, L; Redwan, EMM; Remuzzi, G; Rengasamy, KRR; Renzaho, AMN; Reyes, LF; Rezaei, N; Rezaei, N; Rezaeian, M; Rezazadeh, H; Riahi, SM; Rias, YA; Riaz, M; Ribeiro, D; Rodrigues, M; Rodriguez, JAB; Roever, L; Rohloff, P; Roshandel, G; Roustazadeh, A; Rwegerera, GM; Saad, AMA; Saber-Ayad, MM; Sabour, S; Sabzmakan, L; Saddik, B; Sadeghi, E; Saeed, U; Moghaddam, SS; Safi, S; Safi, SZ; Saghazadeh, A; Sharif-Askari, NS; Sharif-Askari, FS; Sahebkar, A; Sahoo, SS; 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LANCET 402 巻 ( 10397 ) 頁： 203 - 234 2023年7月

掲載種別：研究論文（学術雑誌）出版者・発行元：Lancet

Background: Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of type 1 and type 2 diabetes in 2021, the proportion of the type 2 diabetes burden attributable to selected risk factors, and projections of diabetes prevalence through 2050. Methods: Estimates of diabetes prevalence and burden were computed in 204 countries and territories, across 25 age groups, for males and females separately and combined; these estimates comprised lost years of healthy life, measured in disability-adjusted life-years (DALYs; defined as the sum of years of life lost [YLLs] and years lived with disability [YLDs]). We used the Cause of Death Ensemble model (CODEm) approach to estimate deaths due to diabetes, incorporating 25 666 location-years of data from vital registration and verbal autopsy reports in separate total (including both type 1 and type 2 diabetes) and type-specific models. Other forms of diabetes, including gestational and monogenic diabetes, were not explicitly modelled. Total and type 1 diabetes prevalence was estimated by use of a Bayesian meta-regression modelling tool, DisMod-MR 2.1, to analyse 1527 location-years of data from the scientific literature, survey microdata, and insurance claims; type 2 diabetes estimates were computed by subtracting type 1 diabetes from total estimates. Mortality and prevalence estimates, along with standard life expectancy and disability weights, were used to calculate YLLs, YLDs, and DALYs. When appropriate, we extrapolated estimates to a hypothetical population with a standardised age structure to allow comparison in populations with different age structures. We used the comparative risk assessment framework to estimate the risk-attributable type 2 diabetes burden for 16 risk factors falling under risk categories including environmental and occupational factors, tobacco use, high alcohol use, high body-mass index (BMI), dietary factors, and low physical activity. Using a regression framework, we forecast type 1 and type 2 diabetes prevalence through 2050 with Socio-demographic Index (SDI) and high BMI as predictors, respectively. Findings: In 2021, there were 529 million (95% uncertainty interval [UI] 500–564) people living with diabetes worldwide, and the global age-standardised total diabetes prevalence was 6·1% (5·8–6·5). At the super-region level, the highest age-standardised rates were observed in north Africa and the Middle East (9·3% [8·7–9·9]) and, at the regional level, in Oceania (12·3% [11·5–13·0]). Nationally, Qatar had the world's highest age-specific prevalence of diabetes, at 76·1% (73·1–79·5) in individuals aged 75–79 years. Total diabetes prevalence—especially among older adults—primarily reflects type 2 diabetes, which in 2021 accounted for 96·0% (95·1–96·8) of diabetes cases and 95·4% (94·9–95·9) of diabetes DALYs worldwide. In 2021, 52·2% (25·5–71·8) of global type 2 diabetes DALYs were attributable to high BMI. The contribution of high BMI to type 2 diabetes DALYs rose by 24·3% (18·5–30·4) worldwide between 1990 and 2021. By 2050, more than 1·31 billion (1·22–1·39) people are projected to have diabetes, with expected age-standardised total diabetes prevalence rates greater than 10% in two super-regions: 16·8% (16·1–17·6) in north Africa and the Middle East and 11·3% (10·8–11·9) in Latin America and Caribbean. By 2050, 89 (43·6%) of 204 countries and territories will have an age-standardised rate greater than 10%. Interpretation: Diabetes remains a substantial public health issue. Type 2 diabetes, which makes up the bulk of diabetes cases, is largely preventable and, in some cases, potentially reversible if identified and managed early in the disease course. However, all evidence indicates that diabetes prevalence is increasing worldwide, primarily due to a rise in obesity caused by multiple factors. Preventing and controlling type 2 diabetes remains an ongoing challenge. It is essential to better understand disparities in risk factor profiles and diabetes burden across populations, to inform strategies to successfully control diabetes risk factors within the context of multiple and complex drivers. Funding: Bill & Melinda Gates Foundation.

DOI： 10.1016/S0140-6736(23)01301-6

Work and Family Conflicts, Depression, and "Ikigai": A Mediation Analysis in a Cross-cultural Study Between Japanese and Egyptian Civil Workers 国際共著 Open Access

Eshak, ES; Baba, S; Yatsuya, H; Iso, H; Hirakawa, Y; Mahfouz, EM; Chifa, C; Sakaniwa, R; El-khateeb, AS

JOURNAL OF EPIDEMIOLOGY 33 巻 ( 7 ) 頁： 360 - 366 2023年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: Total work-family conflicts (TWFCs) could associate with mental health, and having ikigai (a purpose of life) may mediate this association. Methods: In a cross-cultural study of 4,792 Japanese Aichi Workers’ Cohort study participants and 3,109 Egyptian civil workers, the Midlife Development in the United States (MIDUS) questionnaire measured TWFCs and the Center for Epidemiological Studies Depression (CES-D) 11-item scale measured depression. We used logistic regression models to estimate odds ratios (ORs) of having depression and a high-ikigai across levels of TWFCs (low, moderate, and high), and the PROCESS macro of Hayes to test the mediation effect. Results: The prevalence of high TWFCs, depression, and having a high ikigai were 17.9%, 39.4%, and 70.1% in Japanese women, 10.5%, 26.8%, and 70.1% in Japanese men, 23.7%, 58.2%, and 24.7% in Egyptian women, and 19.1%, 38.9%, and 36.9% in Egyptian men, respectively. Compared with participants with low TWFCs, the multivariable ORs of depression in Japanese women and men with high TWFCs were 4.11 (95% confidence interval [CI], 2.99–5.65) and 5.42 (95% CI, 4.18–7.02), and those in Egyptian women and men were 4.43 (95% CI, 3.30–5.95) and 4.79 (95% CI, 3.53–6.48), respectively. The respective ORs of having a high-ikigai were 0.46 (95% CI, 0.33–0.64) and 0.40 (95% CI, 0.31–0.52) in Japanese women and men and were 0.34 (95% CI, 0.24–0.48) and 0.28 (95% CI, 0.20–0.39) in Egyptian women and men. No interaction between TWFCs and country was observed for the associations with depression or ikigai. Ikigai mediated (up to 18%) the associations between the TWFCs and depression, especially in Egyptian civil workers. Conclusion: TWFCs were associated with depression, and having low ikigai mediated these associations in Japanese and Egyptian civil workers.

DOI： 10.2188/jea.JE20210338

Impact of combined resection of the internal iliac artery on loss of volume of the gluteus muscles after pelvic exenteration 査読有り

Murata, Y; Uehara, K; Ogura, A; Ishigaki, S; Aiba, T; Mizuno, T; Kokuryo, T; Yokoyama, Y; Yatsuya, H; Ebata, T

SURGERY TODAY 53 巻 ( 7 ) 頁： 791 - 799 2023年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Surgery Today

Purpose: To clarify the influence of additional internal iliac artery (IIA) resection on the loss of the gluteus muscle volume after pelvic exenteration (PE). Methods: The subjects of this retrospective analysis were 78 patients who underwent PE with or without IIA resection (n = 44 and n = 34, respectively) between 2006 and 2018. The areas of gluteal muscles (GMs) and psoas muscles (PSMs) were calculated using CT images before and 6 months after PE, and the difference was compared. Results: The volumes of the GMs and PSMs were significantly reduced after PE (P < 0.001 and P = 0.005, respectively). In the IIA resection group, the GMs were significantly reduced after surgery, but the PSMs were not. The maximum GM (Gmax) was the most atrophied among the GMs. Multivariable analysis revealed that complete IIA resection was an independent promotor of the loss of volume of the Gmax (P = 0.044). In 18 patients with unilateral IIA resection, the downsizing rate of the Gmax was significantly greater on the resected side than on the non-resected side (P = 0.008). Conclusions: The GMs and PSMs were significantly smaller after PE. Complete IIA resection reduced the Gmax area remarkably. Preservation of the superior gluteus artery is likely to help maintain Gmax size, suggesting a potential preventative measure against secondary sarcopenia.

DOI： 10.1007/s00595-022-02635-z

Predictive Value of Long-Term Systolic Blood Pressure Variability for the Development of Type 2 Diabetes Mellitus 査読有り

Yatsuya, H; Song, ZA; Hong, YJ; Mamun, R; Yoshida, Y; Akter, T; Nuamah, G; Tajima, R; Lin, JY; Al-Shoaibi, A; Chiang, C; Nakano, Y; Li, YY; Matsunaga, M; Ota, A; Tamakoshi, K

CIRCULATION 147 巻 2023年2月

Relationship Between Fasting Blood Glucose Levels in Middle Age and Cognitive Function in Later Life: The Aichi Workers' Cohort Study Open Access

Shimoda, M; Kaneko, K; Nakagawa, T; Kawano, N; Otsuka, R; Ota, A; Naito, H; Matsunaga, M; Ichino, N; Yamada, H; Chiang, CF; Hirakawa, Y; Tamakoshi, K; Aoyama, A; Yatsuya, H

JOURNAL OF EPIDEMIOLOGY 33 巻 ( 2 ) 頁： 76 - 81 2023年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: There is limited evidence regarding the relationship between Diabetes mellitus (DM) in middle age and mild cognitive impairment after a follow-up. Therefore, we investigated the relationship between fasting blood glucose (FBG) levels in middle age and cognitive function assessed using the Japanese version of the Montreal Cognitive Assessment (MoCA-J) in later life, following over 15 years of follow-up in the Aichi Workers’ Cohort Study in Japan. Methods: Participants were 253 former local government employees aged 60–79 years in 2018 who participated in a baseline survey conducted in 2002. Using baseline FBG levels and self-reported history, participants were classified into the normal, impaired fasting glucose (IFG) and, and DM groups. Total MoCA-J score ranges from 0 to 30, and cognitive impairment was defined as MoCA-J score ≤25 in this study. A general linear model was used to estimate the mean MoCA-J scores in the FBG groups, adjusted for age, sex, educational year, smoking status, alcohol consumption, physical activity, body mass index, systolic blood pressure, total cholesterol, and estimated glomerular filtration rate. Results: The mean MoCA-J score in the total population was 25.0, and the prevalence of MoCA-J score ≤25 was 49.0%. Multivariable-adjusted total MoCA-J scores were 25.2, 24.8, and 23.4 in the normal, IFG, and DM groups, respectively. The odds ratio of MoCA-J score ≤25 in the DM group was 3.29. Conclusion: FBG level in middle age was negatively associated with total MoCA-J scores assessed later in life, independent of confounding variables.

DOI： 10.2188/jea.JE20210128

Secondhand smoke and the risk of incident cardiovascular disease among never-smoking women (vol 162, 107145, 2022) 査読有り国際誌

Kobayashi, Y; Yamagishi, K; Muraki, I; Kokubo, Y; Saito, I; Yatsuya, H; Iso, H; Tsugane, S; Sawada, N

PREVENTIVE MEDICINE 167 巻頁： 107396 - 107396 2023年2月

The Association Between Adult Height and Stroke Incidence in Japanese Men and Women: A Population-based Case-Control Study Open Access

Kondo, Y; Yatsuya, H; Ota, A; Matsumoto, S; Ueda, A; Watanabe, H; Toyoshima, H

JOURNAL OF EPIDEMIOLOGY 33 巻 ( 1 ) 頁： 23 - 30 2023年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: No studies have examined the associations between adult height and ischemic stroke subtypes. Methods: We conducted a population-based case-control study that included 2,451 thrombotic and 687 embolic stroke cases, as well as 1,623 intracerebral and 768 subarachnoid hemorrhage cases without history of stroke aged 40–79 years, and the same number of sex-and age-matched controls. Cases and controls were grouped according to the quintile cut-off values of height in controls, and the third quintile, which was approximately the average height group, was used as the reference group. Height divided by one standard deviation of height in controls was also examined as a continuous variable. The analyses were carried out separately for participants aged 40–59 years and 60–79 years. Results: In both younger and older men, height was linearly inversely associated with total and thrombotic strokes, and the shortest quintile compared to the reference group was associated with increased risks of these strokes. Although height was linearly inversely associated with embolic stroke and intracerebral hemorrhage in younger men, the shortest quintile did not show increased risks of these strokes. Height did not seem to be associated with total stroke and any stroke subtypes in younger women. In contrast, the tallest quintile was significantly associated with increased risks of total stroke and intracerebral hemorrhage, and height tended to be positively associated with these strokes in older women. Conclusion: We reported the associations between adult height and ischemic stroke subtypes for the first time, which differed according to sex and age group.

DOI： 10.2188/jea.JE20200531

Including measures of chronic kidney disease to improve cardiovascular risk prediction by SCORE2 and SCORE2-OP 査読有り国際共著国際誌 Open Access

Matsushita, K; Kaptoge, S; Hageman, SHJ; Sang, YY; Ballew, SH; Grams, ME; Surapaneni, A; Sun, LL; Arnlov, J; Bozic, M; Brenner, H; Brunskill, NJ; Chang, AR; Chinnadurai, R; Cirillo, M; Correa, A; Ebert, N; Eckardt, KU; Gansevoort, RT; Gutierrez, O; Hadaegh, F; He, J; Hwang, SJ; Jafar, TH; Jassal, SK; Kayama, T; Kovesdy, CP; Landman, GW; Levey, AS; Lloyd-Jones, DM; Major, RW; Miura, K; Muntner, P; Nadkarni, GN; Nowak, C; Ohkubo, T; Pena, MJ; Polkinghorne, KR; Sairenchi, T; Schaeffner, E; Schneider, MP; Shalev, V; Shlipak, MG; Solbu, MD; Stempniewicz, N; Tollitt, J; Valdivielso, JM; van der Leeuw, J; Wang, AYM; Wen, CP; Woodward, M; Yamagishi, K; Yatsuya, H; Zhang, LX; Dorresteijn, JAN; Di Angelantonio, E; Visseren, FLJ; Pennells, L; Coresh, J

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY 30 巻 ( 1 ) 頁： 8 - 16 2023年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：European Journal of Preventive Cardiology

Aims: The 2021 European Society of Cardiology (ESC) guideline on cardiovascular disease (CVD) prevention categorizes moderate and severe chronic kidney disease (CKD) as high and very-high CVD risk status regardless of other factors like age and does not include estimated glomerular filtration rate (eGFR) and albuminuria in its algorithms, systemic coronary risk estimation 2 (SCORE2) and systemic coronary risk estimation 2 in older persons (SCORE2-OP), to predict CVD risk. We developed and validated an 'Add-on' to incorporate CKD measures into these algorithms, using a validated approach. Methods: In 3,054 840 participants from 34 datasets, we developed three Add-ons [eGFR only, eGFR + urinary albumin-to-creatinine ratio (ACR) (the primary Add-on), and eGFR + dipstick proteinuria] for SCORE2 and SCORE2-OP. We validated C-statistics and net reclassification improvement (NRI), accounting for competing risk of non-CVD death, in 5,997 719 participants from 34 different datasets. Results: In the target population of SCORE2 and SCORE2-OP without diabetes, the CKD Add-on (eGFR only) and CKD Add-on (eGFR + ACR) improved C-statistic by 0.006 (95%CI 0.004-0.008) and 0.016 (0.010-0.023), respectively, for SCORE2 and 0.012 (0.009-0.015) and 0.024 (0.014-0.035), respectively, for SCORE2-OP. Similar results were seen when we included individuals with diabetes and tested the CKD Add-on (eGFR + dipstick). In 57 485 European participants with CKD, SCORE2 or SCORE2-OP with a CKD Add-on showed a significant NRI [e.g. 0.100 (0.062-0.138) for SCORE2] compared to the qualitative approach in the ESC guideline. Conclusion: Our Add-ons with CKD measures improved CVD risk prediction beyond SCORE2 and SCORE2-OP. This approach will help clinicians and patients with CKD refine risk prediction and further personalize preventive therapies for CVD.

DOI： 10.1093/eurjpc/zwac176

MEASURES OF LONG-TERM SYSTOLIC BLOOD PRESSURE VARIABILITY AND THEIR ASSOCIATIONS WITH THE RISK OF INCIDENT TYPE 2 DIABETES MELLITUS

Song, ZA; He, YP; Chiang, CF; Alshoaibi, AAA; Rahman, KMSU; Mamun, MR; Aoyama, A; Hirakawa, Y; Matsunaga, M; Ota, A; Tamakoshi, K; Li, YY; Yatsuya, H

JOURNAL OF HYPERTENSION 41 巻頁： E134 - E134 2023年1月

Association of Low-Density Lipoprotein Cholesterol with Risk of Coronary Heart Disease and Stroke among Middle-Aged Japanese Workers: An Analysis using Inverse Probability Weighting 査読有り国際共著 Open Access

Al-Shoaibi, AAA; Li, YY; Song, Z; Chiang, CF; Hirakawa, Y; Saif-Ur-Rahman, KM; Shimoda, M; Nakano, Y; Matsunaga, M; Aoyama, A; Tamakoshi, K; Ota, A; Yatsuya, H

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 30 巻 ( 5 ) 頁： 455 - 466 2023年

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Atherosclerosis and Thrombosis

Aims: The associations between low-density lipoprotein cholesterol (LDL-C) and the risk of cardiovascular disease (CVD) subtypes are not well established among the Japanese population. This study used longitudinal data from the Aichi Workers’ Cohort Study to explore the association between LDL-C levels and the risk of coronary heart disease (CHD) and stroke subtypes. Methods: Pooled data of 8966 adults (7093men and 1903 women) who were recruited between (2002) and (2008) were used for the current analysis. Propensity scores for the LDL-C categories were generated using multinomial logistic regression. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from the inverse probability weighted Cox proportional hazards model for LDL-C category associations with risks of CHD, stroke subtypes, and CVD. Results: During a median follow-up of 12 years, 122 strokes (57 ischemic strokes, 25 intracerebral hemorrhage, and 40 unknown subtypes) and 82 cases of CHD were observed. LDL-C 160– mg/dL compared to LDL-C 100– 119 mg/dL was positively and significantly associated with the risk of CHD (HR: 4.56; 95% CI: 1.91–10.9) but not with ischemic stroke (HR: 0.99; 95% CI: 0.44–2.22). LDL-C was inversely associated with the risk of intracerebral hemorrhage (P for trend=0.009). Conclusion: In middle-aged Japanese workers, LDL-C was significantly and positively associated with CHD, but not with ischemic stroke. LDL-C was inversely significantly associated with intracerebral hemorrhage.

DOI： 10.5551/jat.63519

Sociodemographic and behavioral factors related to obesity among adults in the Republic of Palau based on the WHO STEPwise approach to NCD risk factor surveillance 2011-2013: A cross-sectional study 査読有り国際共著 Open Access

Hasegawa, M; Honjo, K; Chiang, CF; Mita, T; Watson, BM; Ikerdeu, E; Madraisau, S; Yatsuya, H; Aoyama, A; Iso, H

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE 28 巻 ( 0 ) 頁： 39 - 39 2023年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Environmental Health and Preventive Medicine

Background: Pacific islanders face drastic increase of obesity-related noncommunicable disease (NCD) due to lifestyle shifts of unhealthy diets and physical inactivity. To date, however, obesity related factors have not been well elucidated in Republic of Palau. This study aimed to investigate sociodemographic and behavioral factors related to obesity using the national level data in Palau. Methods: This is a cross-sectional, population-based study analyzing random sampling data of 2133 adults aged 25–64 years (of 20 thousand national population) from the WHO STEPwise approach to NCD risk factor surveillance (STEPS) implemented between 2011 and 2013. Sociodemographic and behavioral factors were obtained by the STEPS standardized questionnaire for NCD risk factors plus the question on betel nut chewing because of its common behavior in Micronesian countries. Logistic regression analysis was performed to estimate multivariable odds ratio (OR) of general obesity (body mass index ≥30.0 kg/m2) and central obesity (waist circumference ≥90 cm in men and ≥80 cm in women). Results: Means of body mass index, prevalence of general obesity and central obesity were higher in women (29.9 kg/m2, 45.5% and 85.4%) than in men (29.3 kg/m2, 40.4% and 67.6%). After adjusted by other potential factors, native Palauan (OR 4.4, 95% CI, 2.7–7.0 for men and 3.6, 2.3–5.6 for women), betel nut chewing (1.5, 1.1–2.1 for men and 1.6, 1.2–2.3 for women), men who work at government office (1.6, 1.2–2.1), women with higher household income (1.4, 1.0–1.8) were positively associated with general obesity, while frequent vegetable intake were inversely associated with it among women (0.71, 0.54–0.93). Similar associations were observed between the aforementioned factors and central obesity. Conclusions: Native Palauan, people with betel nut chewing behavior, government employment and higher income appeared to be associated with obesity, while frequent vegetable consumption were inversely associated with obesity. Further interventions for prevention and control of obesity are necessary through the enhancing public relation activities to understand harmful health effects on betel nuts chewing and recommending domestic production of vegetables.

DOI： 10.1265/ehpm.22-00309

Renal Dysfunction after Rectal Cancer Surgery: A Long-term Observational Study Open Access

Sando, M; Uehara, K; Li, YY; Ogura, A; Murata, Y; Mizuno, T; Yatsuya, H; Ebata, T

JOURNAL OF THE ANUS RECTUM AND COLON 7 巻 ( 3 ) 頁： 176 - 185 2023年

記述言語：英語出版者・発行元：Journal of the Anus Rectum and Colon

Objectives: Despite the high incidence of urinary dysfunction (UD) after rectal surgery, it remains questionable whether UD causes future chronic kidney disease (CKD). This study aimed to clarify the long-term trends in renal function and risk factors for future CKD after rectal resection. Methods: For comparison, patients who underwent rectal resection (n = 129) and colectomy (n = 127) between 2006 and 2017 were identified. The estimated glomerular filtration rate (eGFR) ratio was calculated as the ratio to the baseline. “eGFR ratio < 0.75 at 3-year” was adopted as a surrogate indicator of future CKD. Results: eGFR ratio significantly decreased in the rectal cohort compared with the colon cohort at 1.5 years (0.9 vs. 0.95, p = 0.008) and at 3 years (0.85 vs. 0.94, p < 0.001). Although the preoperative prevalence of CKD was lower in the rectal than the colon cohort (13.9% vs. 23.6%, p = 0.055), it was similar at 3 years (29.5% vs. 30.7%). In multivariate analysis, females, and cT4 were independent risk factors for future CKD, but UD itself was not. Conclusions: Postoperative eGFR significantly decreased after rectal cancer surgery compared to colectomy. The prevalence of CKD more than doubled at 3 years after rectal resection. The female sex and cT4 tumor, instead of the UD, were independent risk factors for future CKD.

DOI： 10.23922/jarc.2022-059

Increasing Role of Overweight/Obesity as the Determinant of Hypertension and the Consequent Cardiovascular Diseases in Japan Open Access

Yatsuya, H

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 30 巻 ( 4 ) 頁： 323 - 325 2023年

Psychological Distress During the Coronavirus Disease 2019 Pandemic and Associated Factors Among Undergraduate Students in Japan 査読有り Open Access

Sato, Y; Yatsuya, H; Saijo, Y; Yoshioka, E; Tabuchi, T

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS 17 巻 ( 12 ) 頁： e294 2022年12月

記述言語：英語出版者・発行元：Disaster Medicine and Public Health Preparedness

Objective: This cross-sectional study aimed to examine factors potentially associated with psychological distress among undergraduate students during the coronavirus disease 2019 pandemic in Japan. Methods: We analyzed data of 958 undergraduates (median age 20 y; 56.8% women) from a Web-based, self-administered questionnaire survey conducted from August to September 2020. Prevalence ratios (PRs) for psychological distress defined as 5 points or over of the Kessler Psychological Distress Scale (K6) were calculated by Poisson regression models. Results: The proportion of psychological distress was 40.0%. In the mutually-adjusted model, the following were significantly associated with psychological distress: decreases in household income to 50-99% of the prepandemic amount compared with no change (PR = 1.48), newly experiencing unpaid wages compared with no experience (PR = 1.44), insufficient money to buy necessities compared with no shortage (PR = 1.45), receiving a student loan or scholarship compared with none (PR = 1.27), and communication 1 to 3 times a month compared with at least once a week (PR = 1.22). In contrast, school closure during the pandemic compared with no closure was inversely associated with psychological distress (PR = 0.78). Conclusions: Among undergraduate students in Japan, economic difficulties significantly predicted psychological distress.

DOI： 10.1017/dmp.2022.245

Possible contribution of COVID-19 vaccination to the subsequent mental well-being in Japan 査読有り国際誌 Open Access

Chiang, CF; Morita, S; Hirakawa, Y; Priya, FT; Matsumoto, Y; Ota, A; Yatsuya, H; Tabuchi, T

SCIENTIFIC REPORTS 12 巻 ( 1 ) 頁： 21195 - 21195 2022年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

The coronavirus disease 2019 (COVID-19) pandemic has had a severe impact on mental well-being. Vaccination may have played a pivotal role in enduring this mental health crisis. The present study aimed to longitudinally investigate the association between COVID-19 vaccination and mental health status among Japanese population in 2021. Longitudinal data of 17,089 individuals aged 15–79 years who participated in a nationwide online study were analyzed. Baseline and follow-up mental health statuses were assessed using the Kessler Psychological Distress Scale (K6). General linear and multivariable logistic regression models adjusted for baseline levels of mental distress were used to examine the association between vaccine receipt and follow-up levels of mental health. Mean K6 scores were lower in the vaccinated than in the non-vaccinated participants. Those who had received one or two doses of COVID-19 vaccines were associated with improved mental health at follow-up in subjects with psychological distress at baseline (odds ratio [OR] 1.31 and 1.35, respectively) and were inversely associated with deteriorated mental health status at follow-up in subjects without psychological distress at baseline (OR 0.66 and 0.70, respectively) compared with no vaccination groups, respectively. The present study would indicate that one or two doses of COVID-19 vaccinations contributed to mental well-being in Japan. This finding might provide evidence for promoting vaccination against COVID-19 and emerging infectious diseases in the future.

DOI： 10.1038/s41598-022-25357-1

The association of public trust with the utilization of digital contact tracing for COVID-19 in Japan 査読有り国際誌 Open Access

He, YP; Yatsuya, H; Ota, A; Tabuchi, T

PUBLIC HEALTH IN PRACTICE 4 巻頁： 100279 - 100279 2022年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Public Health in Practice

Objectives: To examin whether public trust was associated with the utilization of COVID-19 Contact Confirming Application (COCOA) in those who self-reported a history of COVID-19. Study design: Cross-sectional study. Methods: Data were obtained from the Japan Society and New Tobacco Internet Survey, a nationwide online survey conducted from February to March 2021, which also assessed items related to COVID-19 and public trust. We included 453 participants with a history of COVID-19. Participants' reports of their general trust in the national government and the related policies, attitudes toward COVID-19 vaccination, and the adherence to the preventive measures against SARS-CoV-2 spread were compared between COCOA users and non-users controlling for age, sex, and socioeconomic statuses by analysis of covariance. Mediation analysis was conducted to examine whether public trust mediates the associations of certain participants’ characteristics with COCOA utilization. Results: Seventy-six percent (344/453) reported the COCOA utilization. Compared to non-users, the users were younger, more likely to be men and had a tendency to have higher education. They were more willing to get COVID-19 vaccination, adherent to public health measures against the spread of the SARS-Cov-2, and more likely to express trust in government in general and policies related to COVID-19 independent of age, sex, and the socioeconomic status. Trust in government did not mediate the associations of age and education with COCOA utilization. Conclusions: The utilization of digital contact tracing technology for the health of public during pandemic was related to the degree of trust in the government in Japan.

DOI： 10.1016/j.puhip.2022.100279

Super-additive associations between parity and education level on mortality from cardiovascular disease and other causes: the Japan Collaborative Cohort Study 査読有り国際誌 Open Access

Yasukawa S., Eguchi E., Tamakoshi A., Iso H., Tamakoshi A., Mori M., Kaneko Y., Tsuji I., Nakamura Y., Yamagishi K., Mikami H., Kurosawa M., Hoshiyama Y., Tanabe N., Tamakoshi K., Wakai K., Ando M., Suzuki K., Hashimoto S., Yatsuya H., Kikuchi S., Wada Y., Okabayashi S., Ozasa K., Mikami K., Sakata K., Kurozawa Y., Fujino Y.

BMC Women S Health 22 巻 ( 1 ) 2022年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMC Women S Health

Background: While women’s parity status and education level have independent associations with cardiovascular and other diseases, no studies have evaluated the additive interaction of these two factors. Therefore, we examined the additive interaction between parity and education level on mortality from stroke, coronary heart disease, total cardiovascular disease, cancer, non-cardiovascular disease, and non-cancer causes, and all causes in Japanese women. Methods: This study followed 41,242 women aged 40–79 years without a history of cardiovascular disease or cancer from 1988 to 1990 until 2009. Baseline parity and education level were classified into four categories, with highly educated parous women as the reference group. Cox proportional hazards regression analyses were performed to calculate the risk of mortality. We also assessed the additive interactions between parity and education level on mortality from cardiovascular disease and other causes using the relative excess risk due to interaction obtained using Cox models. Results: During the median follow-up period of 19.1 years, we identified 6299 deaths. In a multivariable model adjusted for cardiovascular disease and other disease risk factors, nulliparous women with low education levels had increased multivariable-adjusted hazard ratios of 1.67 (95% confidence interval [CI] 1.13, 2.47) for stroke, 1.98 (95% CI 1.15, 3.39) for coronary heart disease, 1.71 (95% CI 1.34,2.18) for total cardiovascular disease, 1.69 (95% CI 1.33, 2.14) for non-cardiovascular and non-cancer, and 1.51 (95% CI 1.30, 1.75) for all-cause mortality when compared with highly educated parous women. Moreover, we observed significant additive interactions between parity and education level on total cardiovascular disease mortality (P = 0.04), non-cardiovascular disease and non-cancer mortality (P = 0.01), and all-cause mortality (P = 0.005). Conclusions: Nulliparity and low education levels are super-additively associated with total cardiovascular disease, non-cardiovascular and non-cancer, and all-cause mortality risks, suggesting that nulliparous women with low education levels need specific support for preventing mortality related to cardiovascular and other diseases.

DOI： 10.1186/s12905-022-01805-y

Association between long-term alcohol consumption and insomnia symptoms in civil servants: Aichi Workers' Cohort Study. 査読有り

Gender Difference in Fear and Anxiety about and Perceived Susceptibility to COVID-19 in the Third Wave of Pandemic among the Japanese General Population: A Nationwide Web-Based Cross-Sectional Survey 査読有り国際誌 Open Access

Sasaki, R; Ota, A; Yatsuya, H; Tabuchi, T

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 19 巻 ( 23 ) 2022年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Environmental Research and Public Health

Existing research suggested gender differences in fear and anxiety about and perceived susceptibility to COVID-19 and previous infectious disease pandemics. We analyzed whether women felt fear and anxiety about and perceived susceptibility to COVID-19 more frequently than men in Japan. We conducted a cross-sectional analysis using internet survey data collected during the third wave of the pandemic in Japan. The subjects were enrolled from the Japanese general population: 11,957 men and 11,559 women. Fear and anxiety specifically related to COVID-19 were evaluated with the Japanese version of the Fear of COVID-19 Scale (FoCS). The question “How likely do you think you will be infected with COVID-19?” was used to assess the perceived susceptibility to COVID-19. Women had higher mean (standard deviation) FoCS scores [18.6 (5.6) vs. 17.5 (5.9), d = 0.190] and reported the median or higher FoCS score (57.4% vs. 51.4%, φ = 0.060) and perceived susceptibility (13.6% vs. 11.5%, φ = 0.032) more frequently than men. The odds ratios (95% confidence intervals) adjusted for age, having a spouse, comorbidities, watching commercial TV stations’ news programs, employment status, and household income were 1.24 (1.17–1.32) and 1.27 (1.16–1.38), respectively. We observed that women were more anxious and fearful about and perceived the susceptibility to infectious diseases more frequently than men even one year after the pandemic occurred in Japan, although the effect size was small.

DOI： 10.3390/ijerph192316239

Terabe M, Kitajima T, Ota A, Yatsuya H, Iwata N

Fujita medical journal 8 巻 ( 4 ) 頁： 103 - 107 2022年11月

Long-term variability and change trend of systolic blood pressure and risk of type 2 diabetes mellitus in middle-aged Japanese individuals: findings of the Aichi Workers' Cohort Study 査読有り国際共著国際誌

Song, ZA; He, YP; Chiang, CF; Al-Shoaibi, AAA; Saif-Ur-Rahman, KM; Mamun, MR; Aoyama, A; Hirakawa, Y; Matsunaga, M; Ota, A; Tamakoshi, K; Li, YY; Yatsuya, H

HYPERTENSION RESEARCH 45 巻 ( 11 ) 頁： 1772 - 1780 2022年11月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Hypertension Research

Studies have reported that short-term blood pressure (BP) variability (BPV) is associated with type 2 diabetes mellitus (T2DM) incidence, but the association with long-term BPV remains unclear. The present study investigated the associations of long-term BPV as well as the time trend of BP changes over time with the incidence of T2DM. This study followed a cohort of 3017 Japanese individuals (2446 male, 571 female) aged 36–65 years from 2007 through March 31, 2019. The root-mean-square error (RMSE) and the slope of systolic BP (SBP) change regressed on year were calculated individually using SBP values obtained from 2003 to baseline (2007). A multivariable Cox proportional hazard model was applied to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for tertiles of SBP RMSE and continuous SBP slopes adjusted for age, sex, smoking status, regular exercise, sodium intake, family history of diabetes, sleep disorder, body mass index (BMI), SBP, and fasting blood glucose (FBG) at baseline, and BMI slope from 2003 to 2007. The highest RMSE tertile compared to the lowest was associated with a significantly higher incidence of T2DM after adjusting for covariates (HR: 1.79, 95% CI: 1.15, 2.78). The slope was also significantly associated with T2DM incidence until baseline SBP and FBG were adjusted (HR: 1.03, 95% CI: 0.99, 1.07). In conclusion, long-term SBP variability was significantly associated with an increased incidence of T2DM independent of baseline age, sex, BMI, SBP, FBG, lifestyle factors and BMI slope from 2003 until baseline.

DOI： 10.1038/s41440-022-00993-2

その他リンク： https://www.nature.com/articles/s41440-022-00993-2

Increased serum anti-CYP2E1 IgG autoantibody levels may be involved in the pathogenesis of occupational trichloroethylene hypersensitivity syndrome: a case-control study 査読有り国際誌 Open Access

Nakajima, T; Wang, HL; Yuan, Y; Ito, Y; Naito, H; Kawamoto, Y; Takeda, K; Sakai, K; Zhao, N; Li, HL; Qiu, XX; Xia, LH; Chen, JB; Wu, QF; Li, LY; Huang, HL; Yanagiba, Y; Yatsuya, H; Kamijima, M

ARCHIVES OF TOXICOLOGY 96 巻 ( 10 ) 頁： 2785 - 2797 2022年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Archives of Toxicology

Occupational exposure to trichloroethylene (TCE) causes a systemic skin disorder with hepatitis known as TCE hypersensitivity syndrome (TCE-HS). Human Leukocyte Antigen (HLA)-B*13:01 is its susceptibility factor; however, the immunological pathogenesis of TCE-HS remains unknown. We herein examined the hypothesis that autoantibodies to CYP2E1 are primarily involved in TCE-HS. A case–control study of 80 TCE-HS patients, 186 TCE-tolerant controls (TCE-TC), and 71 TCE-nonexposed controls (TCE-nonEC) was conducted to measure their serum anti-CYP2E1 antibody (IgG) levels. The effects of TCE exposure indices, such as 8-h time-weighted-average (TWA) airborne concentrations, urinary metabolite concentrations, and TCE usage duration; sex; smoking and drinking habits; and alanine aminotransferase (ALT) levels on the antibody levels were also analyzed in the two control groups. There were significant differences in anti-CYP2E1 antibody levels among the three groups: TCE-TC > TCE-HS patients > TCE-nonEC. Antibody levels were not different between HLA-B*13:01 carriers and noncarriers in TCE-HS patients and TCE-TC. The serum CYP2E1 measurement suggested increased immunocomplex levels only in patients with TCE-HS. Multiple regression analysis for the two control groups showed that the antibody levels were significantly higher by the TCE exposure. Women had higher antibody levels than men; however, smoking, drinking, and ALT levels did not affect the anti-CYP2E1 antibody levels. Anti-CYP2E1 antibodies were elevated at concentrations lower than the TWA concentration of 2.5 ppm for TCE exposure. Since HLA-B*13:01 polymorphism was not involved in the autoantibody levels, the possible mechanism underlying the pathogenesis of TCE-HS is that TCE exposure induces anti-CYP2E1 autoantibody production, and HLA-B*13:01 is involved in the development of TCE-HS.

DOI： 10.1007/s00204-022-03326-x

Association between irregular daily routine and risk of incident stroke and coronary heart disease in a large Japanese population 査読有り国際誌 Open Access

Yoshizaki, T; Ishihara, J; Kotemori, A; Kokubo, Y; Saito, I; Yatsuya, H; Yamagishi, K; Sawada, N; Iwasaki, M; Iso, H; Tsugane, S

SCIENTIFIC REPORTS 12 巻 ( 1 ) 頁： 15750 - 15750 2022年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

Circadian misalignments have been linked to adverse cardiometabolic outcomes. However, the association between irregular daily routine and the risk of cardiovascular disease (CVD) remains unknown. We examined this association in a prospective study in Japan. The study included 78,115 Japanese participants aged 45–74 years. The self-reported daily routine was evaluated using the question, ‘Is your daily routine or activity schedule regular?’ The response (yes/no) was obtained as a binary variable. Cox proportional hazard regression analysis was used to estimate the hazard ratios and 95% confidence intervals for the association between an irregular daily routine and CVD incidence risk. Among the participants, 23.7% reported an irregular daily routine. During the mean follow-up period of 13.3 years, we observed 4641 CVD events. An irregular daily routine was significantly associated with increased risks of CVD and total stroke in women, but not in men. This positive association between an irregular daily routine and the risk of CVD was weak in the high vegetable and fruit consuming population. An irregular daily routine is positively associated with the risk of incident CVD, especially in women. These associations may be weak in populations that consume a diet rich in vegetables and fruits.

DOI： 10.1038/s41598-022-20019-8

Diabetes management in people living with dementia in Japan: a qualitative exploration 査読有り国際誌

KM, SUR; HIRANO, Y; HIRAKAWA, Y; YATSUYA, H

PSYCHOGERIATRICS 22 巻 ( 5 ) 頁： 728 - 735 2022年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Psychogeriatrics

Background: Dementia and diabetes are highly prevalent among the older society in Japan. People living with dementia (PLWD) often face hurdles in managing diabetes. This study explored the perspectives of healthcare providers in Japan regarding diabetes management in PLWD. Methods: We conducted a qualitative study using in-depth interviews as a data collection method. A total of 15 physicians and nurses were interviewed. A qualitative content analysis of the codes was performed to generate the themes. Results: The major themes focused on the management of medications/therapeutic regimen, difficulties of continuing health care, emotional aspects of PLWD for adherence to lifestyle modification, and varying direction and degree of family support for diabetes care. Conclusion: PLWD in Japan face challenges in medication management, food restriction, and lifestyle modification. Policies to engage home visit care workers in medication management, consideration of the emotional aspect of PLWD, and utilisation of social support might help in the proper management of diabetes in PLWD.

DOI： 10.1111/psyg.12876

Secondhand smoke and the risk of incident cardiovascular disease among never-smoking women 査読有り国際誌 Open Access

Kobayashi, Y; Yamagishi, K; Muraki, I; Kokubo, Y; Saito, I; Yatsuya, H; Iso, H; Tsugane, S; Sawada, N

PREVENTIVE MEDICINE 162 巻頁： 107145 - 107145 2022年9月

母体特性と妊娠中期血清n3系多価不飽和脂肪酸濃度の関連

金子佳世, 伊藤由起, 加藤沙耶香, 榎原毅, 八谷寛, 上島通浩

日本公衆衛生学会総会抄録集 81回巻頁： 207 - 207 2022年9月

A comparative study of the work-family conflicts prevalence, their sociodemographic, family, and work attributes, and their relation to the self-reported health status in Japanese and Egyptian civil workers 査読有り国際共著国際誌 Open Access

Abd El Latief, OK; Eshak, ES; Mahfouz, EM; Iso, H; Yatsuya, H; Sameh, EM; Ghazawy, ER; Baba, S; Emam, SA; El-khateeb, AS; Hassan, EE

BMC PUBLIC HEALTH 22 巻 ( 1 ) 頁： 1490 2022年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMC Public Health

Background: Cross-cultural studies studying work-family conflicts (W_F_Cs) are scarce. We compared the prevalence of W_F_Cs, factors correlated with them, and their association with self-rated health between Japan and Egypt. Methods: Among 4862 Japanese and 3111 Egyptian civil workers recruited by a convenience sample in 2018/2019 and reported self-rated health status, we assessed the W_F_Cs by the Midlife Development in the US (MIDUS) and attributed them to sociodemographic, family, and work variables. We also evaluated the W_F_Cs’ gender- and country-specific associations with self-rated health by logistic regression analyses. Results: W_F_Cs were more prevalent in Egyptian than in Japanese women (23.7% vs. 18.2%) and men (19.1% vs. 10.5%), while poor self-rated health was more prevalent in Japanese than Egyptians (19.3% and 17.3% vs. 16.9% and 5.5%). Longer working hours, shift work, and overtime work were positively associated with stronger work-to-family conflict (WFC). Whereas being single was inversely associated with stronger family-to-work conflict (FWC). Living with children, fathers, or alone in Japan while education in Egypt was associated with these conflicts. The OR (95% CI) for poor self-reported health among those with the strong, in reference to weak total W_F_Cs, was 4.28 (2.91–6.30) and 6.01 (4.50–8.01) in Japanese women and men and was 2.46 (1.75–3.47) and 3.11 (1.67–5.80) in Egyptian women and men. Conclusions: Japanese and Egyptian civil workers have different prevalence and correlated factors of W_F_Cs and self-rated health. W_F_Cs were associated in a dose–response pattern with poor-self-rated health of civil workers in both countries.

DOI： 10.1186/s12889-022-13924-0

その他リンク： https://link.springer.com/article/10.1186/s12889-022-13924-0/fulltext.html

[Impact of the COVID-19 pandemic on national and prefectural health and nutrition examination surveys: A report by the Monitoring Report Committee of the Japanese Society of Public Health]. 査読有り Open Access

Kubo A, Kuno K, Maruyama K, Tsukinoki R, Noda H, Egawa K, Shibuya I, Sei M, Chihara M, Nishina K, Yatsuya H

[Nihon koshu eisei zasshi] Japanese journal of public health 69 巻 ( 8 ) 頁： 586 - 594 2022年8月

担当区分：最終著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本公衆衛生学会

目的　新型コロナウイルス感染症の蔓延により2020年度および2021年度の国民健康・栄養調査が中止され，都道府県の調査も中止または延期が予想されたため，日本公衆衛生学会公衆衛生モニタリング・レポート委員会生活習慣病・公衆栄養グループでは都道府県民健康・栄養調査の実施状況を調査し，公衆衛生施策立案のために必要なデータ収集の現状と課題を検討した。方法　47都道府県の調査担当者を対象に，郵送もしくは電子媒体による自記式質問紙調査を実施した。結果　47都道府県（回収率100％）から回答が得られた。健康・栄養調査を実施しているのは44自治体（93.6％）であった。新型コロナウイルス感染症の影響から2020年度調査予定の18自治体のうち「予定通りの内容で実施した」は2（11.1％）「中止した」は16（88.9％）であった。2021年度調査予定の31自治体のうち「予定通りの内容で実施した」は4（12.9％）「内容を一部変更して実施した」は5（16.1％）「中止した」は22（71.0％）であった。今後の調査方法について，身体状況調査実施の32自治体のうち「変更する予定はない」は6（18.8％）「未定」は18（56.3％）であった。栄養摂取状況調査実施の40自治体のうち「変更する予定はない」は12（30.0％）「未定」は19（47.5％）であった。2か年とも調査を中止した13自治体の各種計画評価は「各種計画期間を延長する」8（61.5％）「その他」7（53.8％）であった。2か年に調査を中止または延期した38自治体のうち，各種計画評価に関する問題点は「調査法の変更に伴う経年評価が不可能になる」「コロナ禍でのライフスタイル変化の影響が想定される」「評価に影響はないが評価期間が短縮となる」「国民健康・栄養調査中止により全国比較が不可能である」等があげられた。結論　都道府県健康増進計画等の評価のため，ほとんどの自治体が都道府県民健康・栄養調査を実施していた。また，全国比較ができるよう国民健康・栄養調査と同じ方式で実施する自治体が多かった。新型コロナウイルス感染症の影響により，国民健康・栄養調査と同様に調査を中止する都道府県が多く，今後の調査も未定と回答する自治体が多かった。

DOI： 10.11236/jph.22-020

Dietary Patterns Derived from Reduced Rank Regression Are Associated with the 5-Year Occurrence of Metabolic Syndrome: Aichi Workers' Cohort Study 査読有り国際誌 Open Access

Li, YY; Yatsuya, H; Wang, CC; Uemura, M; Matsunaga, M; He, YP; Khine, M; Ota, A

NUTRIENTS 14 巻 ( 15 ) 頁： 3019 - 3019 2022年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nutrients

The aim of the present study was to derive dietary patterns to explain variation in a set of nutrient intakes or in the measurements of waist circumference (WC) and fasting blood glucose (FBG) using reduced rank regression (RRR) and to prospectively investigate these patterns in relation to the risk of developing metabolic syndrome (MetS) and its components during the follow-up. The study participants were comprised of 2944 government employees aged 30–59 years without MetS. RRR was applied with 38 food groups as predictors and with two sets of response variables. The first set included intake of putatively beneficial nutrients, and the first factor retained was named the Healthy Dietary Pattern (HDP). The second one included baseline WC and FBG, and the first factor was named the Unhealthy Dietary Pattern (UHDP). Multivariable Cox proportional hazard model was used to estimate hazard ratio and 95% confidence intervals with adjustments for age, sex, total energy consumption and other potential confounders. During the 5-year median follow-up, we ascertained 374 cases of MetS. The HDP score was inversely associated with the incidence of MetS (p-trend = 0.009) and hypertension (p-trend = 0.002) and marginally significantly associated with elevated triglyceride and decreased high-density lipoprotein cholesterol (p-trend = 0.08). The UHDP score was linearly positively associated with the incidence of MetS and all its components (all p-trend < 0.05). Both the HDP and UHDP predicted the development of MetS and its components.

DOI： 10.3390/nu14153019

Combined Exoscopic and Endoscopic Two-Step Keyhole Approach for Intracranial Meningiomas 査読有り国際誌 Open Access

Watanabe, T; Iwami, K; Kishida, Y; Nagatani, T; Yatsuya, H; Miyachi, S

CURRENT ONCOLOGY 29 巻 ( 8 ) 頁： 5370 - 5382 2022年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Current Oncology

The advantages of neuroendoscopic surgery are the wide viewing angle and the freedom of an axis of view with minimal surgical trauma. With the advent of the exoscope, which has similar advantages to endoscopy, such as a small body and ergonomically superior heads-up surgery, it has become possible to add a field of view that is similar to that of microsurgery to endoscopic surgery. By taking advantage of the features of these scopes, we report the usefulness of the minimally invasive combined exoscopic and endoscopic two-step keyhole approach (EEKA) for various types of meningiomas. We reviewed data from 34 consecutive cases of EEKA for various types of intracranial meningiomas compared with that of conventional microsurgery. All of the tumors were resected as planned without severe complications. Significantly better outcome data were obtained in terms of the blood loss and the surgical time in the EEKA group, in addition to the craniotomy size. The well-illuminated fine vision in the deep corners by the endoscope enabled radical resection of the tumors with minimum burden on the patients. This technique has the potential for minimally invasive surgery in intracranial meningioma patients, including the older population.

DOI： 10.3390/curroncol29080426

Influence of the COVID-19 pandemic on regular clinic visits and medication prescriptions among people with diabetes: Retrospective cohort analysis of health care claims 査読有り国際誌 Open Access

Maeda, T; Nishi, T; Harada, M; Tanno, K; Nishiya, N; Asayama, K; Okuda, N; Sugiyama, D; Yatsuya, H; Okayama, A; Arima, H

MEDICINE 101 巻 ( 29 ) 頁： e29458 2022年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Medicine United States

The aim of this study was to investigate the effect of the COVID-19 pandemic on regular clinic visits among people with diabetes and to elucidate the factors related to visit patterns among these patients during the pandemic. This was a longitudinal study using anonymized insurance claims data from the Joint Health Insurance Society in Tokyo from October 2017 to September 2020. First, we identified patients with diabetes who were fully enrolled in the health plan from fiscal year 2017 until September 2020 and who were regularly receiving glucose-lowering medications (every 1-3 months) from October 2017 to September 2018. We divided follow-up into the pre-pandemic period (October 2018 to March 2020) and the pandemic period (April 2020 to September 2020). A multilevel logistic regression model was used to determine the risks of delayed clinic visits/medication prescriptions (i.e., >3 months after a previous visit/prescription) during the pandemic period. We identified 1118 study participants. The number of delayed clinic visits/medication prescriptions during the pre-pandemic and pandemic periods was 188/3354 (5.6%) and 125/1118 (11.2%), respectively. There was a significant increase in delayed clinic visits during the pandemic (adjusted odds ratio 3.68 (95% confidence interval 2.24 to 6.04, P <.001), even after controlling for confounding factors. We also found a significant interaction between sex and delayed visits; women had significantly fewer clinic visits during the COVID-19 pandemic than men. We clarified the relationship of the COVID-19 pandemic with delays in regular clinic visits and medication prescriptions among people with diabetes. The response to the COVID-19 pandemic differed between men and women.

DOI： 10.1097/MD.0000000000029458

High Maternal Total Cholesterol Is Associated With No-Catch-up Growth in Full-Term SGA Infants: The Japan Environment and Children's Study 査読有り国際誌 Open Access

Kaneko, K; Ito, Y; Ebara, T; Kato, S; Matsuki, T; Tamada, H; Sato, H; Saitoh, S; Sugiura-Ogasawara, M; Yatsuya, H; Kamijima, M

FRONTIERS IN ENDOCRINOLOGY 13 巻頁： 939366 - 939366 2022年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Frontiers in Endocrinology

Objectives: Infants born small for gestational age (SGA) with no catch-up growth (No-CU) are at high risk of intellectual and developmental disabilities. However, factors leading to No-CU among SGA infants are unclear. This study aimed to examine the association between maternal total cholesterol (TC) in mid-pregnancy and No-CU at 3 years among full-term SGA infants. Study Design: The Japan Environment and Children’s Study (JECS) is a nationwide prospective birth cohort study. We extracted a total of 2,222 mothers and full-term SGA infants (length and/or weight <‐2 standard deviation [SD]) without congenital abnormalities from the original JECS cohort comprising a total of 104,062 fetal records. According to the distribution of maternal TC in the entire cohort, participants were classified into nine groups per each fifth percentile with the 20th–79th percentiles (204–260 mg/dl) as the reference group. No-CU was defined by a Z-score of height at 3 years <‐2 SD according to the growth standard charts for Japanese children. Multivariable-adjusted logistic regression models were carried out using multiple imputations. Additionally, a multiple-adjusted restricted cubic spline model was performed in the complete dataset. Results: A total of 362 (16.3%) children were No-CU at 3 years. After adjusting for the Z-score of birth weight, age of mother, smoking status, weight gain during pregnancy, breastfeeding and meal frequency at 2 years, and parents’ heights, the odds ratio (95% confidence intervals) of No-CU was 2.95 (1.28–6.80) for children whose maternal TC levels were in the highest category (≥294 mg/dl), compared to the reference group. A multiple-adjusted restricted cubic spline model showed a non-linear trend of the significant association between high maternal TC and No-CU (p for linear trend = 0.05, p for quadratic trend <0.05). Conclusion: High maternal TC at mid-pregnancy was associated with No-CU among SGA infants. Such infants should be carefully followed up to introduce appropriate growth hormonal treatment. The findings may support previous animal experimental studies which indicated that maternal high-fat diet exposure induces impairment of growth and skeletal muscle development in the offspring. Future studies are required to elucidate the detailed mechanism.

DOI： 10.3389/fendo.2022.939366

Endoscopic sphincterotomy and endoscopic biliary stenting do not affect the sensitivity of transpapillary forceps biopsy for the diagnosis of bile duct adenocarcinoma 査読有り国際誌 Open Access

Aoki, T; Ohno, E; Ishikawa, T; Mizutani, Y; Iida, T; Yamao, K; Yamamura, T; Furukawa, K; Nakamura, M; Honda, T; Ishigami, M; Yatsuya, H; Kawashima, H

BMC GASTROENTEROLOGY 22 巻 ( 1 ) 頁： 329 2022年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMC Gastroenterology

Background: The pathological evaluation of tissues with cholangitis is considered difficult, which can often occur after endoscopic sphincterotomy (EST) and endoscopic biliary stenting (EBS). This study aimed to evaluate the influence of a history of EST and EBS on the sensitivity of transpapillary forceps bile duct biopsy (TB) for bile duct adenocarcinoma. Methods: This retrospective study included consecutive cases of bile duct adenocarcinoma in which TB was performed before July 2020 until the number exceeded that required to support statistical and noninferiority analyses of the sensitivity of TB between patients with and without each variable. The incidence of postprocedural adverse events related to each factor was also investigated. Results: Overall, 280 samples were required in each group, and 437 subjects (792 samples) were included. The sensitivity of TB was 63.6% for the subjects and 59.6% for the biopsy samples. For the biopsy samples, the sensitivity did not differ significantly between samples from patients with and without a history of EST (59.1% vs. 58.9%, P = 0.952) and EBS (62.1% vs. 55.4%, P = 0.065). The sensitivity was significantly higher for samples from patients with jaundice (67.9% vs. 57.0%, P = 0.008). There were significantly fewer procedure-related adverse events in patients with a history of EST (10.8% vs. 19.0%, P = 0.017) and EBS (12.0% vs. 21.7%, P = 0.005). Conclusions: A history of EST or EBS did not influence sensitivity of TB but significantly decreased the incidence of adverse events. To safely and reliably perform TB to diagnose bile duct adenocarcinoma, planning, including for EST and EBS, is necessary.

DOI： 10.1186/s12876-022-02402-x

新型コロナウイルス感染拡大が日本の医療・介護・福祉の現場にもたらした初期段階の影響に関する質的研究査読有り Open Access

平野有希子, 平川仁尚, 江啓発, 八谷寛

東海公衆衛生雑誌 10 巻 ( 1 ) 頁： 85 - 94 2022年7月

担当区分：最終著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：東海公衆衛生学会

目的　新型コロナウイルス (SARS-COV-2) の感染拡大初期に医療・介護・福祉の現場で起きた課題の構造を整理することは, 今後直面する可能性がある新たな新興感染症への対策策定の第一歩として有用と考えられる。本研究では, 2020年4～5月頃の新型コロナウイルス感染拡大の初期段階における地域の医療・介護・福祉の現場の課題とその構造を実務者の言説の質的分析を通して明らかにすることを目的とした。方法　医療・介護・福祉従事者27名を対象に2020年4月から5月にオンラインインタビュー調査を実施した。インタビューガイドを用いた半構造化インタビューとし, 自由回答形式で行った。録画したインタビュー内容から逐語録を作成し, テキストデータを質的内容分析により分析した。結果　質的内容分析の結果, 126種類の意味単位が抽出された。グループ化により, (1) 不足する情報・十分でない情報共有に対する不安や不満, (2) 業務ならびに社会からの差別に対する心身の疲労, (3) 孤独と貧困に対する対応, (4) 感染予防対策における困難さ, の4テーマが抽出された。結論　本研究の結果から, 新興感染症拡大初期の現場で, 医療資材の不足だけでなく信頼性が高い情報の不足が特に深刻であった。また, 初期に限定した課題ではないが, 医療者の心身の疲労軽減, 孤独や貧困に対する生活支援も重要であった。

DOI： 10.24802/tpha.2022-02

健診で血圧高値を指摘された高血圧症患者の疾患と治療に対する認識と態度査読有り Open Access

洪英在, 平川仁尚, 犬飼麻里子, 水野晴子, 江啓発, 八谷寛

東海公衆衛生雑誌 10 巻 ( 1 ) 頁： 180 - 186 2022年7月

担当区分：最終著者記述言語：日本語出版者・発行元：東海公衆衛生学会

目的　適切に血圧がコントロールされている人を増やすためには, コントロール不良の高血圧症患者に焦点を当て, その要因を明らかにする必要がある。高血圧症は無症候性であることが多いため, 患者本人の疾患や治療に関する認識への働きかけを行うことが重要であるが, そうした研究は少ない。本研究は, 健診でII度以上の血圧高値を指摘された高血圧患者 (すなわち, 良好なコントロール状態にあるとは判断されない高血圧症患者) の疾患と治療に対する認識や態度を探索することを目的とした。方法　対象者は, 愛知県岩倉市が2019年度, 2020年度, 2021年度に実施した特定健診受診者の中から, 一度でも収縮期血圧160mmHg以上または拡張期血圧100mmHg以上であった300名に対して研究参加を呼び掛け, 同意が得られた13名とした。データ収集は1回約30分間の1対1の半構造化面接により行われた。データ分析は, 質的内容分析により行われた。結果　対象者の性別は女性5名, 平均年齢は69.2歳 (60-74歳) であった。2名がBMI 25kg/m2以上の肥満であったがBMI 35kg/m2以上の高度肥満は存在しなかった。13名ともに高血圧症での医療機関通院歴を有し, 8名がかかりつけ医から降圧剤を処方されていた。質的分析の結果, 高血圧に対するイメージ, 治療に関する認識, ピアから受ける影響, 患者からみたかかりつけ医の診療姿勢, 実際に行動変容することの難しさ, の5テーマが抽出された。対象者の中には, 高血圧症に対して重大性を認識していないか, 生活習慣改善に向けて行動を起こすメリットを感じていないようであった。また, 降圧剤について, 必要性を感じず, 副作用を危惧していた。こうした認識は, ピア, つまり同じ疾患を持つ家族・同僚や, かかりつけ医の診療姿勢から影響を受けていた。結論　コントロールが良好でない可能性がある高血圧症患者の疾患と治療に対する認識と態度として, 行動変容の準備性の低さ, 治療内容に関する否定的な認識, ピアからの影響の大きさ, かかりつけ医の診療姿勢への転嫁的態度が存在する可能性があると考えられた。

DOI： 10.24802/tpha.2022-13

特定健診およびレセプトデータを用いた愛知県岩倉市における心血管疾患発症リスクおよび人口寄与危険割合に関するコホート研究査読有り Open Access

江啓発, 藤社紗梨, 水野晴子, 平川仁尚, 八谷寛

東海公衆衛生雑誌 10 巻 ( 1 ) 頁： 166 - 179 2022年7月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：東海公衆衛生学会

目的　特定健診とレセプトの分析に基づき保健事業の効果や効率を高めていくこと (データヘルス計画) が保険者には求められているが、課題設定や被保険者への情報提供に資する実態把握には特定健診受診率や有所見者割合、高額医療費者数等の横断的な検討が中心である。そこで本研究は、愛知県岩倉市国民健康保険 (国保) 加入者の特定健診とその後の経年的なレセプト情報を突合したコホート研究データを用い、心血管疾患発症リスクおよび人口寄与危険割合の推定を試みた。方法　岩倉市国保加入者のうち、2013年から2018年までの5年間に特定健診を1回以上受診した者を対象とし、最初の受診年をベースラインとした。ベースライン以前に心血管疾患の既往歴のある者および問診データに欠損値の多い者を除外した6,496名 (男性2,722名、女性3,774名) を解析対象とした。レセプト情報を用いて追跡期間中の心血管疾患の発症を把握し、特定健診結果から把握した危険因子と全心血管疾患、心筋梗塞、脳卒中の関連を性・年齢および危険因子を相互に調整したCox比例ハザードモデルで検討した。また、多変量調整ハザード比(HR)と発症者における危険因子の割合から人口寄与危険割合を推定した。結果　解析対象者のベースライン時平均年齢は62.5歳であった。追跡期間中の全心血管疾患、心筋梗塞、脳卒中の発症者数はそれぞれ149名、58名、91名であった。女性に比し男性 (HR : 2.0、95%信頼区間 (CI) : 1.4-2.8)、非現喫煙者に比し現喫煙者 (HR : 1.7、95% CI : 1.1-2.5) は心血管疾患発症リスクが約2倍高かった。非高血圧に比しI度およびII度以上高血圧の心血管疾患発症のハザード比はそれぞれ1.7 (95% CI : 1.1-2.4)、2.3 (95% CI : 1.5-3.5) であった。また、糖尿病 (HR : 2.3、95% CI : 1.4-3.9)、メタボリックシンドローム該当者 (HR : 1.6、95% CI : 1.1-2.3) ともに約2倍の心血管疾患発症リスクと関連した。心血管疾患の人口寄与危険割合は高血圧 (I度以上) で27.2%と最も高く、次いで喫煙11.3% メタボリックシンドローム10.5%、糖尿病10.2%であった。結論　高血圧、喫煙、糖尿病、メタボリックシンドロームは性、年齢、その他の危険因子に独立して心血管疾患発症リスク上昇と有意に関連した。心血管疾患の人口寄与危険割合は高血圧で最も高かった。

DOI： 10.24802/tpha.2022-12

Association between C-reactive protein and risk of overall and 18 site-specific cancers in a Japanese case-cohort 査読有り Open Access

Suzuki S., Katagiri R., Yamaji T., Sawada N., Imatoh T., Ihira H., Inoue M., Tsugane S., Iwasaki M., Miyamoto Y., Abe S.K., Tanaka S., Moriya T., Minamizono T., Shirai Y., Kuniyoshi H., Yoshimi T., Sonoda H., Tagami T., Ando T., Kimura T., Kokubo Y., Yamagishi K., Mizoue T., Nakamura K., Takachi R., Ishihara J., Iso H., Kitamura T., Saito I., Yasuda N., Mimura M., Sakata K., Noda M., Goto A., Yatsuya H.

British Journal of Cancer 126 巻 ( 10 ) 頁： 1481 - 1489 2022年6月

記述言語：英語出版者・発行元：British Journal of Cancer

Background: Evidence of the association between chronic low-grade inflammation, as reflected by C-reactive protein (CRP) measurements, and cancer risk is equivocal. Specifically, few studies have examined this in uncommon cancers and Asian populations. Methods: We utilised a case-cohort design consisting of multi-types of cancer (N = 3608), and a random subcohort (N = 4432) in a Japanese large population-based study, with a median follow-up time of 15.6 years, and measured baseline plasma CRP using high sensitivity assay. The hazard ratios (HRs) were estimated using weighted Cox proportional hazards methods. Results: The multivariable-adjusted HR (95% confidence interval) for the top quartile of CRP was 1.28 (1.11‒1.48) (P<inf>trend</inf> < 0.001) for overall cancer compared to the bottom quartile of CRP. Among site-specific cancers, higher CRP levels were associated with an increased risk of colorectal, lung, breast, biliary tract, and kidney cancer, and leukaemia. These positive associations remained among participants after >3 years’ follow-up. Furthermore, subgroup analyses for overall cancer robustly showed a positive association with CRP levels, regardless of sex and obesity. Conclusion: Our consistent findings suggested that chronic low-grade inflammation measured by CRP is associated with the risk of cancer.

DOI： 10.1038/s41416-022-01715-8

Stoma creation is associated with a low incidence of midline incisional hernia after colorectal surgery: the "fighting over the fascia" theory concerning the incision and stoma hole 査読有り

Ohara, N; Uehara, K; Ogura, A; Sando, M; Aiba, T; Murata, Y; Mizuno, T; Toshio, K; Yokoyama, Y; Ishigaki, S; Li, YY; Yatsuya, H; Ebata, T

SURGERY TODAY 52 巻 ( 6 ) 頁： 953 - 963 2022年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Surgery Today

Purpose: Parastomal hernia (PH) develops more frequently than incisional hernia (IH) after colorectal surgery with stoma. This study evaluated our hypothesis that inward traction of the fascia when closing a midline incision widens the stoma hole and increases the incidence of PH. Methods: A total of 795 patients who underwent colorectal resection between 2006 and 2016 were retrospectively analyzed. The risk classification was constructed from IH risk factors extracted from the non-stoma group. Then, the classification was extrapolated to the stoma group for predicting midline IH and PH. Results: The incidence of IH was 5.3% in the stoma group and 12.5% in the non-stoma group (p = 0.005). PH developed in 19.6% of 97 patients with permanent stoma. The risk classification was able to predict PH without a significant difference but was well balanced in patients with permanent stoma; however, it failed to predict IH in the stoma group. Conclusion: The risk classification constructed from the non-stoma group was useful for predicting not midline IH but PH, suggesting that the stoma site was the most vulnerable for herniation. The “fighting over the fascia” theory between the midline incision and stoma hole may explain the causal relationship between the midline IH and PH.

DOI： 10.1007/s00595-021-02434-y

Prioritization and sequential exclusion of articles in systematic reviews 査読有り国際共著国際誌 Open Access

Saif-Ur-Rahman, KM; Hasan, M; Hossain, S; Anwar, I; Hirakawa, Y; Yatsuya, H

CAMPBELL SYSTEMATIC REVIEWS 18 巻 ( 2 ) 頁： e1229 2022年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Campbell Systematic Reviews

It is difficult to match the causes of exclusion among two independent review authors after screening the title and abstract or full texts in systematic reviews. We have proposed the prioritization and sequential exclusion approach to reduce the subjectivity in reporting reasons for exclusion. This approach might reduce the burden of mismatched numbers while describing the cause of exclusion.

DOI： 10.1002/cl2.1229

Implementation strategies for the patient safety reporting system using Consolidated Framework for Implementation Research: a retrospective mixed-method analysis 査読有り Open Access

Koike, D; Ito, M; Horiguchi, A; Yatsuya, H; Ota, A

BMC HEALTH SERVICES RESEARCH 22 巻 ( 1 ) 頁： 409 2022年3月

記述言語：英語出版者・発行元：BMC Health Services Research

Background: Healthcare-related adverse events occur because of complex healthcare systems. The patient safety reporting system is a core component of patient safety initiatives in hospitals. However, hospital management often encounters a cultural barrier with its implementation and struggles to overcome the same. Implementation science would be useful for analysing implementation strategies. This study determines the effects of the implemented strategy on an increase in the number of patient safety reports and the determinants of successful implementation, using the implementation framework. Methods: Mixed method analysis was performed in Fujita Health University Hospital (FHUH), a large volume hospital in Japan. We identified strategies to implement the patient safety reporting system by scrutinising internal documents using the Consolidated Framework for Implementation Research (CFIR). The electronic reporting systems developed in 2004 in the FHUH and the number of reports were analysed using the staff data and hospital volumes. Results: Reports (n = 110,058) issued between April 2004 and March 2020 were analysed. The number of reports increased from 2004 to 2008 and from 2013 to 2019, reaching 14,037 reports per year. Between 2009 and 2012, the FHUH experienced a stagnation period where the number of reports were not increasing. From the qualitative materials, we identified 74 strategies which contributed to the implementation of the patient safety reporting system. Among these, the domain of ‘intervention characteristics’ in the CFIR contained 12 strategies, ‘outer settings’ contained 20, ‘inner settings’ contained 21, ‘characteristics of individuals’ contained 8, and ‘process’ contained 13. There were two concentrated periods of the implemented strategies, the number was 17 in 2007 and 10 in 2016. These concentrated periods preceded a remarkable increase in the number of patient safety reports. Conclusions: A safety culture had been fostered in FHUH in the study period. A relationship between number of strategies and development of a reporting culture was observed. The intensity of adequate strategies was needed for implementation of patient safety reporting system. Therefore, the implementation framework is useful for analysing patient safety initiatives for safety culture.

DOI： 10.1186/s12913-022-07822-9

Low Density Lipoprotein Cholesterol Associations With The Risk Of Coronary Heart Disease And Stroke Among Middle-aged Japanese Workers: Analysis Using Inverse Probability Weighting

Al-shoaibi, AA; Li, YY; Chiang, C; Hirakawa, Y; Song, Z; Saif-Ur-Rahman, KM; Masako, S; Masaaki, M; Aoyama, A; Tamakoshi, K; Ota, A; Yatsuya, H

CIRCULATION 145 巻 2022年3月

Smoking cessation, weight gain and risk of cardiovascular disease 査読有り国際誌

Wang, XW; Dong, JY; Cui, RZ; Muraki, I; Shirai, K; Yamagishi, K; Kokubo, Y; Saito, I; Yatsuya, H; Sawada, N; Iso, H; Tsugane, S

HEART 108 巻 ( 5 ) 頁： 375 - 381 2022年3月

職業性ストレスと退職後の認知機能低下に関する縦断的研究愛知職域コホート研究

中島啓裕, 江啓発, 平川仁尚, He Yupeng, 霜田真子, 玉腰浩司, 八谷寛

産業ストレス研究 29 巻 ( 1 ) 頁： 169 - 169 2022年3月

Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019 査読有り国際共著 Open Access

Cousin, E; Duncan, BB; Stein, C; Ong, KL; Vos, T; Abbafati, C; Abbasi-Kangevari, M; Abdelmasseh, M; Abdoli, A; Abd-Rabu, R; Abolhassani, H; Abu-Gharbieh, E; Accrombessi, MMK; Adnani, QES; Afzal, MS; Agarwal, G; Agrawaal, KK; Agudelo-Botero, M; Ahinkorah, BO; Ahmad, S; Ahmad, T; Ahmadi, K; Ahmadi, S; Ahmadi, A; Ahmed, A; Salih, YA; Akande-Sholabi, W; Akram, T; Al Hamad, H; Al-Aly, Z; Alcalde-Rabanal, JE; Alipour, V; Aljunid, SM; Al-Raddadi, RM; Alvis-Guzman, N; Amini, S; Ancuceanu, R; Andrei, T; Andrei, CL; Anjana, RM; Ansar, A; Antonazzo, IC; Antony, B; Anyasodor, AE; Arabloo, J; Arizmendi, D; Armocida, B; Artamonov, AA; Arulappan, J; Aryan, Z; Asgari, S; Ashraf, T; Astell-Burt, T; Atorkey, P; Atout, MMW; Ayanore, MA; Badiye, AD; Baig, AA; Bairwa, M; Baker, JL; Baltatu, OC; Banik, PC; Barnett, A; Barone, MTU; Barone-Adesi, F; Barrow, A; Bedi, N; Belete, R; Belgaumi, UI; Bell, AW; Bennett, DA; Bensenor, IM; Beran, D; Bhagavathula, AS; Bhaskar, S; Bhattacharyya, K; Bhojaraja, VS; Bijani, A; Bikbov, B; Birara, S; Bodolica, V; Bonny, A; Brenner, H; Briko, NI; Butt, ZA; dos Santos, FLC; Camera, LA; Campos-Nonato, IR; Cao, Y; Cao, C; Cerin, E; Chakraborty, PA; Chandan, JS; Chattu, VK; Chen, SM; Choi, JYJ; Choudhari, SG; Chowdhury, EK; Chu, DT; Corso, B; Dadras, O; Dai, XC; Damasceno, AAM; Dandona, L; Dandona, R; Dávila-Cervantes, CA; De Neve, JW; Denova-Gutiérrez, E; Dhamnetiya, D; Diaz, D; Ebtehaj, S; Edinur, HA; Eftekharzadeh, S; El Sayed, I; Elgendy, IY; Elhadi, M; Elmonem, MA; Faisaluddin, M; Farooque, U; Feng, XQ; Fernandes, E; Fischer, F; Flood, D; Freitas, M; Gaal, PA; Gad, MM; Gaewkhiew, P; Getacher, L; Ghafourifard, M; Gheshlagh, RG; Ghashghaee, A; Ghith, N; Ghozali, G; Gill, PS; Ginawi, IA; Glushkova, EV; Golechha, M; Gopalani, SV; Guimaraes, RA; Das Gupta, R; Gupta, R; Gupta, VK; Gupta, VB; Gupta, S; Habtewold, TD; Hafezi-Nejad, N; Halwani, R; Hanif, A; Hankey, GJ; Haque, S; Hasaballah, AI; Hasan, SS; Hashi, A; Hassanipour, S; Hay, SI; Hayat, K; Heidari, M; Hossain, MBH; Hossain, S; Hosseini, M; Hoveidamanesh, S; Huang, JJ; Humayun, A; Hussain, R; Hwang, BF; Ibitoye, SE; Ikuta, KS; Inbaraj, LR; Iqbal, U; Islam, MS; Islam, SMS; Islam, RM; Ismail, NE; Isola, G; Itumalla, R; Iwagami, M; Iyamu, IO; Jahani, MA; Jakovljevic, M; Jayawardena, R; Jha, RP; John, O; Jonas, JB; Joo, T; Kabir, A; Kalhor, R; Kamath, A; Kanchan, T; Kandel, H; Kapoor, N; Kayode, GA; Kebede, SA; Keshavarz, P; Keykhaei, M; Khader, YS; Khajuria, H; Khan, MAB; Khan, MN; Khan, M; Khater, AM; Khoja, TAM; Khubchandani, J; Kim, MS; Kim, YJ; Kimokoti, RW; Kisa, S; Kisa, A; Kivimäki, M; Korshunov, VA; Korzh, O; Koyanagi, A; Krishan, K; Defo, BK; Kumar, GA; Kumar, N; Kusuma, D; La Vecchia, C; Lacey, B; Larsson, AO; Lasrado, S; Lee, WC; Lee, CB; Lee, PH; Lee, SWH; Li, MC; Lim, SS; Lim, LL; Lucchetti, G; Majeed, A; Malik, AA; Mansouri, B; Mantovani, LG; Martini, S; Mathur, P; McAlinden, C; Mehedi, N; Mekonnen, T; Menezes, RG; Mersha, AG; Jonasson, JM; Miazgowski, T; Michalek, IM; Mirica, A; Mirrakhimov, EM; Mirza, AZ; Mithra, P; Mohammadian-Hafshejani, A; Mohammadpourhodki, R; Mohammed, A; Mokdad, AH; Molokhia, M; Monasta, L; Moni, MA; Moradpour, F; Moradzadeh, R; Mostafavi, E; Mueller, UO; Murray, CJL; Mustafa, A; Nagel, G; Nangia, V; Naqvi, AA; Nayak, BP; Nazari, J; Ndejjo, R; Negoi, RI; Kandel, N; Nguyen, CT; Nguyen, HLT; Noubiap, JJ; Nowak, C; Oancea, B; Odukoya, OO; Oguntade, AS; Ojo, TT; Olagunju, AT; Onwujekwe, OE; Ortiz, A; Owolabi, MO; Palladino, R; Panda-Jonas, S; Pandi-Perumal, SR; Pardhan, S; Parekh, T; Parvizi, M; Pepito, VCF; Perianayagam, A; Petcu, IR; Pilania, M; Podder, V; Polibin, RV; Postma, MJ; Prashant, A; Rabiee, N; Rabiee, M; Rahimi-Movaghar, V; Rahman, MA; Rahman, MM; Rahman, M; Rahmawaty, S; Rajai, N; Ram, P; Rana, J; Ranabhat, K; Ranasinghe, P; Rao, CR; Rao, S; Rawaf, S; Rawaf, DL; Rawal, L; Renzaho, AMN; Rezaei, N; Rezapour, A; Riahi, SM; Ribeiro, D; Rodriguez, JAB; Roever, L; Rohloff, P; Rwegerera, GM; Ryan, PM; Saber-Ayad, MM; Sabour, S; Saddik, B; Moghaddam, SS; 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Zhang, ZJ; Zhong, CW; Zmaili, M; Zumla, A; Naghavi, M; Schmidt, MI

LANCET DIABETES & ENDOCRINOLOGY 10 巻 ( 3 ) 頁： 177 - 192 2022年3月

記述言語：英語出版者・発行元：Lancet Diabetes and Endocrinology

Background: Diabetes, particularly type 1 diabetes, at younger ages can be a largely preventable cause of death with the correct health care and services. We aimed to evaluate diabetes mortality and trends at ages younger than 25 years globally using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods: We used estimates of GBD 2019 to calculate international diabetes mortality at ages younger than 25 years in 1990 and 2019. Data sources for causes of death were obtained from vital registration systems, verbal autopsies, and other surveillance systems for 1990–2019. We estimated death rates for each location using the GBD Cause of Death Ensemble model. We analysed the association of age-standardised death rates per 100 000 population with the Socio-demographic Index (SDI) and a measure of universal health coverage (UHC) and described the variability within SDI quintiles. We present estimates with their 95% uncertainty intervals. Findings: In 2019, 16 300 (95% uncertainty interval 14 200 to 18 900) global deaths due to diabetes (type 1 and 2 combined) occurred in people younger than 25 years and 73·7% (68·3 to 77·4) were classified as due to type 1 diabetes. The age-standardised death rate was 0·50 (0·44 to 0·58) per 100 000 population, and 15 900 (97·5%) of these deaths occurred in low to high-middle SDI countries. The rate was 0·13 (0·12 to 0·14) per 100 000 population in the high SDI quintile, 0·60 (0·51 to 0·70) per 100 000 population in the low-middle SDI quintile, and 0·71 (0·60 to 0·86) per 100 000 population in the low SDI quintile. Within SDI quintiles, we observed large variability in rates across countries, in part explained by the extent of UHC (r2=0·62). From 1990 to 2019, age-standardised death rates decreased globally by 17·0% (−28·4 to −2·9) for all diabetes, and by 21·0% (–33·0 to −5·9) when considering only type 1 diabetes. However, the low SDI quintile had the lowest decline for both all diabetes (−13·6% [–28·4 to 3·4]) and for type 1 diabetes (−13·6% [–29·3 to 8·9]). Interpretation: Decreasing diabetes mortality at ages younger than 25 years remains an important challenge, especially in low and low-middle SDI countries. Inadequate diagnosis and treatment of diabetes is likely to be major contributor to these early deaths, highlighting the urgent need to provide better access to insulin and basic diabetes education and care. This mortality metric, derived from readily available and frequently updated GBD data, can help to monitor preventable diabetes-related deaths over time globally, aligned with the UN's Sustainable Development Targets, and serve as an indicator of the adequacy of basic diabetes care for type 1 and type 2 diabetes across nations. Funding: Bill & Melinda Gates Foundation.

DOI： 10.1016/S2213-8587(21)00349-1

Everyday wishes of older people living with dementia in care planning: a qualitative study 査読有り Open Access

Mamun, MR; Hirakawa, Y; Saif-Ur-Rahman, KM; Sakaguchi, T; Chiang, C; Yatsuya, H

BMC HEALTH SERVICES RESEARCH 22 巻 ( 1 ) 頁： 184 2022年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMC Health Services Research

Background: The dementia care policy in Japan emphasizes the views of people living with dementia in care planning. An exploration of the everyday wishes of older people living with dementia can help clarify their priorities and assist in improving dementia care. This study aimed to explore the everyday wishes of older people living with dementia in Japan. Methods: This qualitative study was conducted in Aichi prefecture in Japan. Older people with mild to moderate dementia were considered for inclusion. Participants were recruited from a dementia outpatient clinic. In-depth interviews were conducted with 36 participants in the same dementia outpatient clinic from January to October 2019. Audio-recorded interviews were transcribed verbatim. Inductive content analysis was carried out to analyze the data. Findings: Participants expressed their everyday wishes within five themes (desire of being connected, freedom to decide, involvement in activities, status quo, and self-reliance). Older people living with dementia loved the connection with their family and wanted to have an enjoyable life by engaging in several activities without others’ interference. They desired to maintain the status quo and not be a burden to others. Conclusions: This study provides evidence on the everyday wishes of people living with dementia. Identified wishes are mostly on emotional aspects of their daily lives. The findings of our study might help provide care for the people living with dementia considering their wishes. Further exploration, including people with severe dementia, is needed.

DOI： 10.1186/s12913-022-07606-1

その他リンク： https://link.springer.com/article/10.1186/s12913-022-07606-1/fulltext.html

Age and sex differences in factors associated with hypertension among an urban poor population in Bangladesh 査読有り Open Access

Al-Shoaibi, AAA; Chiang, CF; Khalequzzaman, M; Choudhury, SR; Hirakawa, Y; Islam, SS; Aoyama, A; Yatsuya, H

NAGOYA JOURNAL OF MEDICAL SCIENCE 84 巻 ( 1 ) 頁： 69 - 79 2022年2月

記述言語：英語出版者・発行元：Nagoya Journal of Medical Science

This study explores the differences in factors associated with hypertension between younger and older subjects in an urban slum community in Bangladesh. We analyzed the data of 1,008 men and 1,001 women obtained from a cross-sectional survey conducted between October 2015 and April 2016. Multivariable logistic regression models were stratified by age (18 to 44 and 45 to 64 years) in men and women separately. The multivariable model included age (continuous) and the following categorical variables simultaneously: education duration, marital status, tobacco smoking, smokeless tobacco use, total physical activity, body mass index (BMI), waist circumference, and the blood levels of glycated hemoglobin (HbA1c), triglycerides, high and low-density lipoprotein (HDL and LDL) cholesterol. Hypertension was defined as the presence of either blood pressure ≥140/90 mmHg or the use of antihypertensive medication. The prevalence of hypertension was 13.0% (younger men), 14.6% (younger women), 35.6% (older men), and 38.7% (older women). In younger men, higher waist circumference and increased LDL cholesterol levels were significantly associated with hypertension. In older men, physical activity was the only significant factor that was inversely associated with hypertension. In younger women, higher BMI, increased HbA1c, triglycerides, and LDL cholesterol levels were associated with hypertension. In older women, a higher HbA1c was the only factor significantly associated with hypertension. These findings suggest that public health interventions to prevent hypertension may require different approaches according to sex and age groups within the poor urban population in Bangladesh.

DOI： 10.18999/nagjms.84.1.69

Comparison of laminoplasty and posterior fusion surgery for cervical ossification of posterior longitudinal ligament 査読有り Open Access

Nakashima, H; Imagama, S; Yoshii, T; Egawa, S; Sakai, K; Kusano, K; Nakagawa, Y; Hirai, T; Wada, K; Katsumi, K; Fujii, K; Kimura, A; Furuya, T; Kanchiku, T; Nagamoto, Y; Oshima, Y; Nagoshi, N; Ando, K; Takahata, M; Mori, K; Nakajima, H; Murata, K; Matsunaga, S; Kaito, T; Yamada, K; Kobayashi, S; Kato, S; Ohba, T; Inami, S; Fujibayashi, S; Katoh, H; Kanno, H; Li, YY; Yatsuya, H; Koda, M; Kawaguchi, Y; Takeshita, K; Matsumoto, M; Yamazaki, M; Okawa, A

SCIENTIFIC REPORTS 12 巻 ( 1 ) 頁： 748 2022年1月

記述言語：英語出版者・発行元：Scientific Reports

This prospective multicenter study, established by the Japanese Ministry of Health, Labour and Welfare and involving 27 institutions, aimed to compare postoperative outcomes between laminoplasty (LM) and posterior fusion (PF) for cervical ossification of the posterior longitudinal ligament (OPLL), in order to address the controversy surrounding the role of instrumented fusion in cases of posterior surgical decompression for OPLL. 478 patients were considered for participation in the study; from among them, 189 (137 and 52 patients with LM and PF, respectively) were included and evaluated using the Japanese Orthopaedic Association (JOA) scores, the JOA Cervical Myelopathy Evaluation Questionnaire (JOACMEQ), and radiographical measurements. Basic demographic and radiographical data were reviewed, and the propensity to choose a surgical procedure was calculated. Preoperatively, there were no significant differences among the participants in terms of patient backgrounds, radiographical measurements (K-line or cervical alignment on X-ray, OPLL occupation ratio on computed tomography, increased signal intensity change on magnetic resonance imaging), or clinical status (JOA score and JOACMEQ) after adjustments. The overall risk of perioperative complications was found to be lower with LM (odds ratio [OR] 0.40, p = 0.006), and the rate of C5 palsy occurrence was significantly lower with LM (OR 0.11, p = 0.0002) than with PF. The range of motion (20.91° ± 1.05° and 9.38° ± 1.24°, p < 0.0001) in patients who had PF was significantly smaller than in those who had LM. However, multivariable logistic regression analysis showed no significant difference among the participants in JOA score, JOA recovery rate, or JOACMEQ improvement at two years. In contrast, OPLL progression was greater in the LM group than in the PF group (OR 2.73, p = 0.0002). Both LM and PF for cervical myelopathy due to OPLL had resulted in comparable postoperative outcomes at 2 years after surgery.

DOI： 10.1038/s41598-021-04727-1

Impact of Body Mass Index on Obesity-Related Cancer and Cardiovascular Disease Mortality; The Japan Collaborative Cohort Study 国際誌 Open Access

Matsunaga, M; Yatsuya, H; Iso, H; Li, YY; Yamagishi, K; Tanabe, N; Wada, Y; Ota, A; Tamakoshi, K; Tamakoshi, A

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 29 巻 ( 10 ) 頁： 1547 - 1562 2022年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Atherosclerosis and Thrombosis

Aim: We aimed to examine the association of obesity-related cancer and cardiovascular disease (CVD) with body mass index (BMI) and the estimated population attributable fraction in lean Asians. Methods: We studied 102,535 participants aged 40–79 years without histories of cancer or CVD at baseline between 1988 and 2009. The cause-specific hazard ratios (csHRs) of BMI categories (＜18.5, 18.5–20.9, 21.0– 22.9 [reference], 23.0–24.9, 25.0–27.4, and ≥ 27.5 kg/m2) were estimated for each endpoint. The events considered were mortalities from obesity-related cancer (esophageal, colorectal, liver, pancreatic, kidney, female breast, and endometrial cancer) and those from CVD (coronary heart disease and stroke). Population attributable fractions (PAFs) were calculated for these endpoints. Results: During a 19.2-year median follow-up, 2906 died from obesity-related cancer and 4532 died from CVD. The multivariable-adjusted csHRs (95% confidence interval) of higher BMI categories (25–27.4 and ≥ 27.5 kg/m2) for obesity-related cancer mortality were 0.93 (0.78, 1.10) and 1.18 (0.92, 1.50) in men and 1.25 (1.04, 1.50) and 1.48 (1.19, 1.84) in women, respectively. The corresponding csHRs for CVD mortality were 1.27 (1.10, 1.46) and 1.59 (1.30, 1.95) in men and 1.10 (0.95, 1.28) and 1.44 (1.21, 1.72) in women, respectively. The PAF of a BMI ≥ 25 kg/m2 for obesity-related cancer was −0.2% in men and 6.7% in women and that for CVD was 5.0% in men and 4.5% in women. Conclusion: A BMI ≥ 25 kg/m2 is associated with an increased risk of obesity-related cancer in women and CVD in both sexes.

DOI： 10.5551/jat.63143

Change in the Number of Patient Safety Reports Through a 16-Year Patient Safety Initiative: A Retrospective Study Focusing on the Incident Severity and Type in a Japanese Hospital 査読有り国際誌 Open Access

Koike, D; Ito, M; Horiguchi, A; Yatsuya, H; Ota, A

RISK MANAGEMENT AND HEALTHCARE POLICY 15 巻頁： 2071 - 2081 2022年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Risk Management and Healthcare Policy

Purpose: To describe the long-term quantitative change in the number of submissions of patient safety reports after the introduction of a patient safety reporting system, focusing on incident severity and type. Patients and Methods: This study was performed at a tertiary care hospital in Japan. Patient safety reports from 2006 to 2020 were retrospectively reviewed. Incident severity was classified from level 0 (near miss) to level 5 (fatality). The incident types included those related to medication, patient care, drains and catheters, procedures and interventions, examinations, medical devices, and blood transfusions. The study period was divided into 1. 2004–2007; 2. 2008–2014; and 3. 2015–2020 based on the implementation of hospital patient safety strategies. The number of reports per hospital worker was compared among the study periods and the incident levels and types. Results: We analyzed 96,332 reports extracted from the patient safety reporting system of the hospital. The total number of reports per hospital worker has increased over time. The numbers of levels 0 and 1 incidents increased throughout the study period. In addition, levels 3a and 3b incidents increased between periods 2 and 3. All incident types, except for procedure and intervention-related incidents, increased between periods 1 and 2 and between periods 1 and 3. The number of procedure and intervention-related incidents increased between periods 2 and 3, although it did not between periods 1 and 2. Conclusion: We found increases in the number of patient safety reports according to the incident severity and type. This suggests two contextual changes occurring during the cultural maturity process, which reflected the development of organizational patient safety culture in our institution. The first was the establishment of a reporting attitude in the institution. The second was to overcome barriers to patient safety.

DOI： 10.2147/RMHP.S385453

Prediction of Lifetime Risk of Cardiovascular Disease Deaths Stratified by Sex in the Japanese Population 査読有り国際誌 Open Access

Yukiko Imai, Sachiko Mizuno Tanaka, Michihiro Satoh, Takumi Hirata, Yoshitaka Murakami, Katsuyuki Miura, Takashi Waki, Aya Hirata, Toshimi Sairenchi, Fujiko Irie, Mizuki Sata, Toshiharu Ninomiya, Takayoshi Ohkubo, Shizukiyo Ishikawa, Yoshihiro Miyamoto, Hirofumi Ohnishi, Shigeyuki Saitoh, Akiko Tamakoshi, Michiko Yamada, Masahiko Kiyama, Hiroyasu Iso, Kiyomi Sakata, Hideaki Nakagawa, Akira Okayama, Hirotsugu Ueshima, Tomonori Okamura, Yutaka Imai, Akihiko Kitamura, Yutaka Kiyohara, Akiko Harada, Masaru Sakurai, Takeo Nakayama, Ichiro Tsuji, Yoshihiro Kokubo, Hiroshi Yatsuya, Tomonori Okamura

Journal of the American Heart Association 10 巻 ( 23 ) 2021年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Ovid Technologies (Wolters Kluwer Health)

<sec xml:lang="en">
<title>Background</title>
Lifetime risk is an informative estimate for driving lifestyle and behavioral changes especially for young adults. The impact of composite risk factors for cardiovascular disease on lifetime risk stratified by sex has not been investigated in the Japanese population, which has a much lower mortality of coronary heart disease compared with the Western population. We aimed to estimate lifetime risk of death from cardiovascular disease attributable to traditional risk factors.

</sec>
<sec xml:lang="en">
<title>Methods and Results</title>
We analyzed pooled individual data from the Evidence for Cardiovascular Prevention from Observational Cohorts in a Japanese cohort study. A modified Kaplan–Meier approach was used to estimate the remaining lifetime risk of cardiovascular death. In total, 41 002 Japanese men and women with 537 126 person‐years of follow‐up were included. The lifetime risk at the index‐age of 45 years for those with optimal risk factors (total cholesterol <4.65 mmol/L, systolic blood pressure <120 mm Hg, diastolic blood pressure <80 mm Hg, absence of diabetes, and absence of smoking habit) was lower compared with the highest risk profile of ≥2 risk factors (6.8% [95% CI, 0%–11.9%] versus 19.4% [16.7%–21.4%] for men and 6.9% [1.2%–11.5%] versus 15.4% [12.6%–18.1%] for women).

</sec>
<sec xml:lang="en">
<title>Conclusions</title>
The magnitude and the number of risk factors were progressively associated with increased lifetime risk even in individuals in early adulthood who tend to have low short‐term risk. The degree of established cardiovascular risk factors can be converted into lifetime risk. Our findings may be useful for risk communication in the early detection of future cardiovascular disease risk.

</sec>

DOI： 10.1161/jaha.121.021753

Seasonal variation in submacular hemorrhages in retinal macroaneurysms and its disappearance in age-related macular degeneration 査読有り

Working cancer survivors' physical and mental characteristics compared to cancer-free workers in Japan: a nationwide general population-based study 査読有り国際誌 Open Access

Ota, A; Li, YY; Yatsuya, H; Tanno, K; Sakata, K; Yamagishi, K; Iso, H; Yasuda, N; Saito, I; Kato, T; Arima, K; Sou, Y; Shimazu, T; Yamaji, T; Goto, A; Inoue, M; Iwasaki, M; Sawada, N; Tsugane, S

JOURNAL OF CANCER SURVIVORSHIP 15 巻 ( 6 ) 頁： 912 - 921 2021年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Cancer Survivorship

Purpose: This study compared working cancer survivors’ self-rated health status (SRHS), physical functional capacity, depressive symptoms, and happiness to those of cancer-free workers. Methods: A nationwide general population-based cross-sectional study on a sample of Japanese was conducted. Prevalence of deteriorated SRHS, restricted physical functional capacity, depressive symptoms, and perceived happiness were compared between working cancer survivors and cancer-free workers with multivariable logistic regression analysis adjusted for age and sociodemographic and health-related backgrounds. Results: Of the 28,311 male and 26,068 female workers, 977 (3.5%) and 1267 (4.9%) were cancer survivors, respectively. Working cancer survivors reported deteriorated SRHS more frequently than cancer-free workers: 21.3% vs. 13.8%, multivariable-adjusted odds ratio (95% confidence interval), 1.64 (1.39–1.95) for men, 23.8% vs. 17.5%, 1.34 (1.16–1.54) for women. Restricted physical functional capacity was reported more frequently in working cancer survivors than cancer-free workers: 6.8% vs. 2.6%, 1.76 (1.34–2.32) for men, 4.9% vs. 2.0%, 2.06 (1.56–2.71) for women. No significant difference was found for depressive symptoms: 21.6% vs. 22.9% in men, 30.0% vs. 28.5% in women. Working cancer survivors felt happiness more frequently than cancer-free survivors in men (77.3% vs. 71.7%, 1.21 (1.01–1.45)) but not in women (76.1% vs. 74.9%). Conclusions: Working cancer survivors had worse SRHS and more restricted physical functional capacity than cancer-free workers. In men, working cancer survivors felt happiness more frequently than cancer-free workers. Implications for Cancer Survivors: Continuous support to improve cancer survivors’ SRHS and physical functional capacity would be necessary even while they are working.

DOI： 10.1007/s11764-020-00984-7

Kaneko, H; Takashi, N; Matsunaga, M; Ito, Y; Takeuchi, J; Terasaki, H; Yatsuya, H; Nishiguchi, KM

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 259 巻 ( 12 ) 頁： 3589 - 3596 2021年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Graefe S Archive for Clinical and Experimental Ophthalmology

Purpose: To investigate whether previously reported seasonal variation and winter-dominant prevalence of acute massive submacular hemorrhages (SMHs) caused by age-related macular degeneration (AMD) disappeared, and those caused by retinal microaneurysms (RMAs) emerged. Method: The medical charts of 95 patients (95 eyes) with SMH caused by AMD and 76 patients (76 eyes) with SMH caused by RMAs in 2012–2019 were retrospectively reviewed. For each subject, the month of onset, the mean ambient temperature of that month were recorded. Results: The monthly numbers of cases of SMHs caused by AMD from January to December were 6, 8, 4, 9, 7, 10, 9, 11, 7, 11, 3, and 10. No significant seasonal variation in the monthly incidence was identified (Roger’s R = 1.89, p = 0.39). The monthly numbers of SMHs caused by RMAs from January to December were 3, 11, 11, 8, 7, 8, 5, 5, 2, 4, 7, and 5. There was significant seasonal variation in the monthly incidence (Roger’s R = 7.67, p = 0.02). There was no significant correlation between the monthly incidence of SMHs caused by RMAs and mean ambient temperature. Conclusion: Our previous study conducted for cases obtained in 1998–2005 showed seasonal cyclic trend in the number of SMHs caused by AMD, with the peak in winter. However, that significant seasonal variation disappeared in 2012–2019 in the present study. Common usage of OCT devices and anti-VEGF drugs might be the reason for the lack of seasonal variation in the cases of SMH caused by AMD. [Figure not available: see fulltext.]

DOI： 10.1007/s00417-021-05280-3

The Association of Work-related Stress According to the Demand-Control Model With Aggravation of Pre-existing Disease During the First State of COVID-19 Emergency in Japan Open Access

He, YP; Yatsuya, H; Chiang, CF; Ota, A; Okubo, R; Ishimaru, T; Tabuchi, T

JOURNAL OF EPIDEMIOLOGY 31 巻 ( 12 ) 頁： 635 - 640 2021年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: The job environment has changed a lot during the period of the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to investigate the association between work-related stress and aggravation of pre-existing disease in workers during the first state of COVID-19 emergency in Japan. Methods: Data were obtained from a large internet survey conducted between August 25 and September 30, 2020 in Japan. Participants who reported that they had a job as well as current history of disease(s) (ie, pre-existing conditions) were included (n = 3,090). Aggravation of pre-existing disease during the state of emergency was self-reported. Work-related stress from April 2020 (since the state of COVID-19 emergency) was assessed according to a job demand–control model. Multivariable logistic regression models were used to analyze the association. Results: Aggravation of pre-existing diseases was reported by 334 participants (11%). The numbers of participants with high demand and low control were 112 (18%) and 100 (14%), respectively. Compared to medium demand, high demand was significantly associated with aggravation of pre-existing diseases (odds ratio 1.77; 95% confidence interval, 1.30–2.42). Low control compared to medium control was also significantly associated with aggravation of pre-existing diseases (odds ratio 1.39; 95% confidence interval, 1.02–1.92). Conclusion: Work-related stress during the first state of COVID-19 emergency was associated with aggravation of pre-existing disease during that period.

DOI： 10.2188/jea.JE20210146

Peanut Consumption and Risk of Stroke and Ischemic Heart Disease in Japanese Men and Women The JPHC Study 査読有り国際誌 Open Access

Ikehara, S; Iso, H; Kokubo, Y; Yamagishi, K; Saito, I; Yatsuya, H; Kimura, T; Sawada, N; Iwasaki, M; Tsugane, S

STROKE 52 巻 ( 11 ) 頁： 3543 - 3550 2021年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Stroke

Background and Purpose: Several prospective cohort studies and a randomized clinical trial have shown the beneficial effects of peanut consumption on cardiovascular disease and its risk factors. We examined the association between peanut consumption and risk of cardiovascular disease in Japanese men and women. Methods: We analyzed data of 74 793 participants aged 45 to 74 years who completed a lifestyle questionnaire including the validated food frequency questionnaire in the Japan Public Health Center-based Prospective Study. They were followed up from 1995 to 2009 for cohort I and from 1998 to 1999 to 2012 for cohort II. Peanut consumption was calculated from the food frequency questionnaire, and the end points were incidence of stroke, ischemic heart disease, and cardiovascular disease (stroke and ischemic heart disease). Results: During a median follow-up of 14.8 years, 3,599 strokes and 849 ischemic heart diseases were reported. Higher peanut consumption was associated with reduced risks of total stroke, ischemic stroke, and cardiovascular disease among men and women. The multivariable hazard ratios (95% CIs) for the highest versus lowest quartiles of peanut consumption after adjustment for age, sex, public health center, smoking, alcohol consumption, perceived stress level, physical activity, vegetable, fruit, fish, soy, sodium and total energy intakes, body mass index, history of hypertension, history of diabetes, and cholesterol-lowering drug were 0.84 (0.77-0.93, P for trend=0.002) for total stroke, 0.80 (0.71-0.90, P for trend=0.002) for ischemic stroke, 0.93 (0.79-1.08, P for trend=0.27) for hemorrhagic stroke, 0.97 (0.80-1.17, P for trend=0.81) for ischemic heart disease and 0.87 (0.80-0.94, P for trend=0.004) for cardiovascular disease, and these associations were similarly observed in both sexes. Conclusions: Higher peanut consumption was associated with reduced risk of stroke, especially ischemic stroke, but not ischemic heart disease in Japanese men and women.

DOI： 10.1161/STROKEAHA.120.031212

Having hobbies and the risk of cardiovascular disease incidence: A Japan public health center-based study 査読有り国際誌

Wang, XW; Dong, JY; Shirai, K; Yamagishi, K; Kokubo, Y; Saito, I; Yatsuya, H; Iso, H; Tsugane, S; Sawada, N

ATHEROSCLEROSIS 335 巻頁： 1 - 7 2021年10月

アポリポ蛋白A2のアイソフォームと心筋梗塞発症との関連に関するコホート内症例対照研究多目的コホート(JPHC)研究

木原朋未, 山岸良匡, 本田一文, 池田愛, 八谷寛, 斉藤功, 小久保喜弘, 山地太樹, 島津太一, 澤田典絵, 岩崎基, 磯博康, 津金昌一郎

日本動脈硬化学会総会プログラム・抄録集 53回巻頁： 232 - 232 2021年10月

Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019 Open Access

Feigin, VL; Stark, BA; Johnson, CO; Roth, GA; Bisignano, C; Abady, GG; Abbasifard, M; Abbasi-Kangevari, M; Abd-Allah, F; Abedi, V; Abualhasan, A; Abu-Rmeileh, NM; Abushouk, A; Adebayo, OM; Agarwal, G; Agasthi, P; Ahinkorah, BO; Ahmad, S; Ahmadi, S; Salih, YA; Aji, B; Akbarpour, S; Akinyemi, RO; Al Hamad, H; Alahdab, F; Alif, SM; Alipour, V; Aljunid, SM; Almustanyir, S; Al-Raddadi, RM; Salman, RAS; Alvis-Guzman, N; Ancuceanu, R; Anderlini, D; Anderson, JA; Ansar, A; Antonazzo, IC; Arabloo, J; Ärnlöv, J; Artanti, KD; Aryan, Z; Asgari, S; Ashraf, T; Athar, M; Atreya, A; Ausloos, M; Baig, AA; Baltatu, OC; Banach, M; Barboza, MA; Barker-Collo, SL; Bärnighausen, TW; Barone, MTU; Basu, S; Bazmandegan, G; Beghi, E; Beheshti, M; Béjot, Y; Bell, AW; Bennett, DA; Bensenor, IM; Bezabhe, WM; Bezabih, YM; Bhagavathula, AS; Bhardwaj, P; Bhattacharyya, K; Bijani, A; Bikbov, B; Birhanu, MM; Boloor, A; Bonny, A; Brauer, M; Brenner, H; Bryazka, D; Butt, ZA; dos Santos, FLC; Campos-Nonato, IR; Cantu-Brito, C; Carrero, JJ; Castañeda-Orjuela, CA; Catapano, AL; Chakraborty, PA; Charan, J; Choudhari, SG; Chowdhury, EK; Chu, DT; Chung, SC; Colozza, D; Costa, VM; Costanzo, S; Criqui, MH; Dadras, O; Dagnew, B; Dai, X; Dalal, K; Damasceno, AAM; D'Amico, E; Dandona, L; Dandona, R; Gela, JD; Davletov, K; De La Cruz-Góngora, V; Desai, R; Dhamnetiya, D; Dharmaratne, SD; Dhimal, ML; Dhimal, M; Diaz, D; Dichgans, M; Dokova, K; Doshi, R; Douiri, A; Duncan, BB; Eftekharzadeh, S; Ekholuenetale, M; El Nahas, N; Elgendy, IY; Elhadi, M; El-Jaafary, S; Endres, M; Endries, AY; Erku, DA; Faraon, EJA; Farooque, U; Farzadfar, F; Feroze, AH; Filip, I; Fischer, F; Flood, D; Gad, MM; Gaidhane, S; Gheshlagh, RG; Ghashghaee, A; Ghith, N; Ghozali, G; Ghozy, S; Gialluisi, A; Giampaoli, S; Gilani, SA; Gill, PS; Gnedovskaya, E; Golechha, M; Goulart, AC; Guo, YM; Gupta, R; Gupta, VB; Gupta, VK; Gyanwali, P; Hafezi-Nejad, N; Hamidi, S; Hanif, A; Hankey, GJ; Hargono, A; Hashi, A; Hassan, TS; Hassen, HY; Havmoeller, RJ; Hay, S; Hayat, K; Hegazy, M; Herteliu, C; Holla, R; Hostiuc, S; Househ, M; Huang, J; Humayun, A; Hwang, BF; Iacoviello, L; Iavicoli, I; Ibitoye, SE; Ilesanmi, OS; Ilic, IM; Ilic, MD; Iqbal, U; Irvani, SSN; Islam, SMS; Ismail, NE; Iso, H; Isola, G; Iwagami, M; Jacob, L; Jain, V; Jang, SI; Jayapal, SK; Jayaram, S; Jayawardena, R; Jeemon, P; Jha, RP; Johnson, WD; Jonas, JB; Joseph, N; Jozwiak, JJ; Jürisson, M; Kalani, R; Kalhor, R; Kalkonde, Y; Kamath, A; Kamiab, Z; Kanchan, T; Kandel, H; Karch, A; Katoto, PDMC; Kayode, GA; Keshavarz, P; Khader, YS; Khan, EA; Khan, IA; Khan, M; Khan, MAB; Khatib, MN; Khubchandani, J; Kim, GR; Kim, MS; Kim, YJ; Kisa, A; Kisa, S; Kivimäki, M; Kolte, D; Koolivand, A; Laxminarayana, SLK; Koyanagi, A; Krishan, K; Krishnamoorthy, V; Krishnamurthi, R; Kumar, GA; Kusuma, D; La Vecchia, C; Lacey, B; Lak, HM; Lallukka, T; Lasrado, S; Lavados, PM; Leonardi, M; Li, BY; Li, SS; Lin, HL; Lin, RT; Liu, XF; Lo, WD; Lorkowski, S; Lucchetti, G; Saute, RL; Razek, HMA; Magnani, FG; Mahajan, PB; Majeed, A; Makki, A; Malekzadeh, R; Malik, AA; Manafi, N; Mansournia, MA; Mantovani, LG; Martini, S; Mazzaglia, G; Mehndiratta, MM; Menezes, RG; Meretoja, A; Mersha, AG; Jonasson, JM; Miazgowski, B; Miazgowski, T; Michalek, IM; Mirrakhimov, EM; Mohammad, Y; Mohammadian-Hafshejani, A; Mohammed, S; Mokdad, AH; Mokhayeri, Y; Molokhia, M; Moni, MA; Al Montasir, A; Moradzadeh, R; Morawska, L; Morze, J; Muruet, W; Musa, KI; Nagarajan, AJ; Naghavi, M; Swamy, SN; Nascimento, BR; Negoi, RI; Kandel, SN; Nguyen, TH; Norrving, B; Noubiap, JJ; Nwatah, VE; Oancea, B; Odukoya, OO; Olagunju, AT; Orru, H; Owolabi, MO; Padubidri, JR; Pana, A; Parekh, T; Park, EC; Kan, FP; Pathak, M; Peres, MFP; Perianayagam, A; Pham, TM; Piradov, MA; Podder, V; Polinder, S; Postma, MJ; Pourshams, A; Radfar, A; Rafiei, A; Raggi, A; Rahim, F; Rahimi-Movaghar, V; Rahman, M; Rahman, MA; Rahmani, AM; Rajai, N; Ranasinghe, P; Rao, CR; Rao, SJ; Rathi, P; Rawaf, DL; Rawaf, S; Reitsma, MB; Renjith, V; Renzaho, AMN; Rezapour, A; Rodriguez, JAB; Roever, L; Romoli, M; Rynkiewicz, A; Sacco, S; Sadeghi, M; Moghaddam, SS; Sahebkar, A; Saif-Ur-Rahman, K; Salah, R; Samaei, M; Samy, AM; Santos, IS; Santric-Milicevic, MM; Sarrafzadegan, N; Sathian, B; Sattin, D; Schiavolin, S; Schlaich, MP; Schmidt, MI; Schutte, AE; Sepanlou, SG; Seylani, A; Sha, F; Shahabi, S; Shaikh, MA; Shannawaz, M; Shawon, MSR; Sheikh, A; Sheikhbahaei, S; Shibuya, K; Siabani, S; Silva, DAS; Singh, JA; Singh, JK; Skryabin, VY; Skryabina, AA; Sobaih, BH; Stortecky, S; Stranges, S; Tadesse, EG; Tarigan, IU; Temsah, MH; Teuschl, Y; Thrift, AG; Tonelli, M; Tovani-Palone, MR; Tran, BX; Tripathi, M; Tsegaye, GW; Ullah, A; Unim, B; Unnikrishnan, B; Vakilian, A; Tahbaz, SV; Vasankari, TJ; Venketasubramanian, N; Vervoort, D; Vo, B; Volovici, V; Vosoughi, K; Vu, GT; Vu, LG; Wafa, HA; Waheed, Y; Wang, YZ; Wijeratne, T; Winkler, AS; Wolfe, CDA; Woodward, M; Wu, JH; Hanson, SW; Xu, XY; Yadav, L; Yadollahpour, A; Jabbari, SHY; Yamagishi, K; Yatsuya, H; Yonemoto, N; Yu, CH; Yunusa, I; Zaman, MS; Bin Zaman, S; Zamanian, M; Zand, R; Zandifar, A; Zastrozhin, MS; Zastrozhina, A; Zhang, Y; Zhang, ZJ; Zhong, C; Zuniga, YMH; Murray, CJL

LANCET NEUROLOGY 20 巻 ( 10 ) 頁： 795 - 820 2021年10月

出版者・発行元：Lancet Neurology

Background Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. Methods We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level. Findings In 2019, there were 12·2 million (95% UI 11·0–13·6) incident cases of stroke, 101 million (93·2–111) prevalent cases of stroke, 143 million (133–153) DALYs due to stroke, and 6·55 million (6·00–7·02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11·6% [10·8–12·2] of total deaths) and the third-leading cause of death and disability combined (5·7% [5·1–6·2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70·0% (67·0–73·0), prevalent strokes increased by 85·0% (83·0–88·0), deaths from stroke increased by 43·0% (31·0–55·0), and DALYs due to stroke increased by 32·0% (22·0–42·0). During the same period, age-standardised rates of stroke incidence decreased by 17·0% (15·0–18·0), mortality decreased by 36·0% (31·0–42·0), prevalence decreased by 6·0% (5·0–7·0), and DALYs decreased by 36·0% (31·0–42·0). However, among people younger than 70 years, prevalence rates increased by 22·0% (21·0–24·0) and incidence rates increased by 15·0% (12·0–18·0). In 2019, the age-standardised stroke-related mortality rate was 3·6 (3·5–3·8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3·7 (3·5–3·9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62·4% of all incident strokes in 2019 (7·63 million [6·57–8·96]), while intracerebral haemorrhage constituted 27·9% (3·41 million [2·97–3·91]) and subarachnoid haemorrhage constituted 9·7% (1·18 million [1·01–1·39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79·6 million [67·7–90·8] DALYs or 55·5% [48·2–62·0] of total stroke DALYs), high body-mass index (34·9 million [22·3–48·6] DALYs or 24·3% [15·7–33·2]), high fasting plasma glucose (28·9 million [19·8–41·5] DALYs or 20·2% [13·8–29·1]), ambient particulate matter pollution (28·7 million [23·4–33·4] DALYs or 20·1% [16·6–23·0]), and smoking (25·3 million [22·6–28·2] DALYs or 17·6% [16·4–19·0]). Interpretation The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries.

DOI： 10.1016/S1474-4422(21)00252-0

Associations of insomnia with noise annoyance and neighborhood environments: A nationwide cross-sectional study in Japan 査読有り国際誌 Open Access

Hanibuchi, T; Nakaya, T; Kitajima, T; Yatsuya, H

PREVENTIVE MEDICINE REPORTS 23 巻頁： 101416 - 101416 2021年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Preventive Medicine Reports

Despite the increasing knowledge on the association between neighborhood and health, few studies have investigated sleep disorders in Japan, particularly the impact of neighborhood noise on sleep. Thus, this study aimed to investigate the associations between insomnia symptoms and annoyance because of traffic and neighborhood noise in Japan, which has different neighborhood conditions compared with those of the western societies. Neighborhood built and socioeconomic environments roles were also examined. We used nationwide cross-sectional data collected through a 2015 online survey of Japanese adults aged 20–64 years (n = 4,243). Adjusted prevalence ratios for insomnia according to the exposures were estimated using the multilevel Poisson regression models. The results showed that having insomnia was significantly associated with experiencing neighborhood and traffic-noise annoyance. Neighborhood noise had a stronger and independent association with insomnia. However, the neighborhood environmental variables, including population density, deprivation index, and access to commercial areas, were not associated with insomnia. In conclusion, noise annoyance, particularly that sourced from neighbors, is an important factor in relation to sleep health. Health and urban-planning policymakers should consider neighborhood noise, in addition to traffic noise, as health-related issues in residential neighborhoods.

DOI： 10.1016/j.pmedr.2021.101416

Association of anthropometric indices of obesity with hypertension among public employees in northern Ethiopia: findings from a cross-sectional survey 査読有り国際共著 Open Access

Saif-Ur-Rahman, KM; Chiang, CF; Gebremariam, LW; Hilawe, EH; Hirakawa, Y; Aoyama, A; Yatsuya, H

BMJ OPEN 11 巻 ( 9 ) 頁： e050969 2021年9月

記述言語：英語出版者・発行元：BMJ Open

Objectives: The burden of hypertension is increasing in low-income countries, including Ethiopia. Obesity is widely known to be associated with hypertension, but different anthropometric indices of obesity might differ in association with hypertension, which is largely unknown in northern Ethiopia. Design: Data from our previous cross-sectional epidemiological survey were statistically analysed. Setting: Public employees in the regional capital city in northern Ethiopia. Participants: The data of 1380 participants (823 men and 557 non-pregnant women) aged 25 and 64 years were analysed. Outcome measures: The presence of hypertension was the outcome measure and multivariable-adjusted logistic regression analyses were used to investigate the association of body mass index (BMI), waist circumference, and waist-hip ratio in men and women separately. The area under the curve (AUC) for three anthropometric indices for discriminating hypertension was also obtained. Separate analyses were conducted for waist circumference and waist-hip ratio analyses further adjusted for BMI. Results: BMI was linearly associated with hypertension in men (OR for 1 SD increase in BMI 1.45, p=0.001) and women (OR for 1 SD increase in BMI 1.41, p=0.01). The association of waist circumference was independent of BMI both in men (OR for 1 SD increase in waist circumference: 1.74, p=0.002) and women (OR for 1 SD increase in waist circumference: 1.57, p=0.029). The association of waist-hip ratio with hypertension adjusted for BMI was significant in men (OR for 1 SD increase in the waist-hip ratio: 1.46, p<0.001), but was weak and non-significant in women. The AUC for BMI was 0.64 in men and 0.67 in women, while AUC for waist circumference was 0.69 both in men and women. Conclusions: Waist circumference was associated with hypertension independent of BMI among public employees in northern Ethiopia.

DOI： 10.1136/bmjopen-2021-050969

Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study

Murai, U; Yamagishi, K; Sata, M; Kokubo, Y; Saito, I; Yatsuya, H; Ishihara, J; Inoue, M; Sawada, N; Iso, H; Tsugane, S

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 50 巻 2021年9月

The association of work-related stress with aggravation of pre-existing disease during COVID-19 emergency in Japan Open Access

He, YP; Yatsuya, H; Chiang, C; Ota, A; Okubo, R; Ishimaru, T; Tabuchi, T

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 50 巻 2021年9月

小学2年非肥満児における男女別の推定食塩摂取量、尿中Na/K比と収縮期血圧の関連

金子佳世, 伊藤由起, 加藤沙耶香, 玉田葉月, 松木太郎, 榎原毅, 井上貴子, 杉浦真弓, 齋藤伸治, 八谷寛, 藤田直也, 上島通浩

東海公衆衛生雑誌 9 巻 ( 1 ) 頁： 49 - 49 2021年7月

Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019 査読有り国際共著国際誌 Open Access

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Gupta, T; Gupta, V; Hafezi-Nejad, N; Haider, MR; Hamadeh, RR; Hankey, GJ; Hargono, A; Hartono, RK; Hassankhani, H; Hay, SI; Heidari, G; Herteliu, C; Hezam, K; Hird, TR; Hole, MK; Holla, R; Hosseinzadeh, M; Hostiuc, S; Househ, M; Hsiao, T; Huang, JJ; Iannucci, VC; Ibitoye, SE; Idrisov, B; Ilesanmi, OS; Ilic, IM; Ilic, MD; Inbaraj, LR; Irvani, SSN; Islam, JY; Islam, RM; Islam, SMS; Islami, F; Iso, H; Itumalla, R; Iwagami, M; Jaafari, J; Jain, V; Jakovljevic, M; Jang, SI; Janjani, H; Jayaram, S; Jeemon, P; Jha, RP; Jonas, JB; Joo, T; Jürisson, M; Kabir, A; Kabir, Z; Kalankesh, LR; Kanchan, T; Kandel, H; Kapoor, N; Karimi, SE; Katikireddi, SV; Kebede, HK; Kelkay, B; Kennedy, RD; Khoja, AT; Khubchandani, J; Kim, GR; Kim, YE; Kimokoti, RW; Kivimäki, M; Kosen, S; Laxminarayana, SLK; Koyanagi, A; Krishan, K; Kugbey, N; Kumar, GA; Kumar, N; Kurmi, OP; Kusuma, D; Lacey, B; Lam, JO; Landires, I; Lasrado, S; Lauriola, P; Lee, DW; Lee, YH; Leung, JN; Li, SS; Lin, HL; Linn, S; Liu, W; Lopez, AD; Lopukhov, PD; 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Zhang, ZJ; Zhong, CW; Zuniga, YMH; Gakidou, E

LANCET 397 巻 ( 10292 ) 頁： 2337 - 2360 2021年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Lancet

Background: Ending the global tobacco epidemic is a defining challenge in global health. Timely and comprehensive estimates of the prevalence of smoking tobacco use and attributable disease burden are needed to guide tobacco control efforts nationally and globally. Methods: We estimated the prevalence of smoking tobacco use and attributable disease burden for 204 countries and territories, by age and sex, from 1990 to 2019 as part of the Global Burden of Diseases, Injuries, and Risk Factors Study. We modelled multiple smoking-related indicators from 3625 nationally representative surveys. We completed systematic reviews and did Bayesian meta-regressions for 36 causally linked health outcomes to estimate non-linear dose-response risk curves for current and former smokers. We used a direct estimation approach to estimate attributable burden, providing more comprehensive estimates of the health effects of smoking than previously available. Findings: Globally in 2019, 1·14 billion (95% uncertainty interval 1·13–1·16) individuals were current smokers, who consumed 7·41 trillion (7·11–7·74) cigarette-equivalents of tobacco in 2019. Although prevalence of smoking had decreased significantly since 1990 among both males (27·5% [26·5–28·5] reduction) and females (37·7% [35·4–39·9] reduction) aged 15 years and older, population growth has led to a significant increase in the total number of smokers from 0·99 billion (0·98–1·00) in 1990. Globally in 2019, smoking tobacco use accounted for 7·69 million (7·16–8·20) deaths and 200 million (185–214) disability-adjusted life-years, and was the leading risk factor for death among males (20·2% [19·3–21·1] of male deaths). 6·68 million [86·9%] of 7·69 million deaths attributable to smoking tobacco use were among current smokers. Interpretation: In the absence of intervention, the annual toll of 7·69 million deaths and 200 million disability-adjusted life-years attributable to smoking will increase over the coming decades. Substantial progress in reducing the prevalence of smoking tobacco use has been observed in countries from all regions and at all stages of development, but a large implementation gap remains for tobacco control. Countries have a clear and urgent opportunity to pass strong, evidence-based policies to accelerate reductions in the prevalence of smoking and reap massive health benefits for their citizens. Funding: Bloomberg Philanthropies and the Bill & Melinda Gates Foundation.

DOI： 10.1016/S0140-6736(21)01169-7

What constitutes healthiness of Washoku or Japanese diet? 招待有り国際誌 Open Access

Yatsuya, H; Tsugane, S

EUROPEAN JOURNAL OF CLINICAL NUTRITION 75 巻 ( 6 ) 頁： 863 - 864 2021年6月

Predictive risk factors for pneumothorax after transbronchial biopsy using endobronchial ultrasonography with a guide sheath 査読有り国際誌 Open Access

Gotoh, Y; Yamaguchi, T; Yatsuya, H; Ikeda, A; Okamura, T; Sakakibara, Y; Ina, T; Maeda, Y; Hirochi, M; Kako, H; Goto, Y; Isogai, S; Yamamoto, N; Kondo, M; Imaizumi, K

BMC PULMONARY MEDICINE 21 巻 ( 1 ) 頁： 181 - 181 2021年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMC Pulmonary Medicine

Background: Pneumothorax is one complication of transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath (EBUS-GS-TBB). We sought to clarify the risk factors for pneumothorax after EBUS-GS-TBB under fluoroscopic guidance. Methods: We retrospectively reviewed data from 916 patients who underwent EBUS-GS-TBB at Fujita Health University Hospital. We evaluated the following risk factors for pneumothorax after EBUS-GS-TBB: patient characteristics (sex, age, and pulmonary comorbidities); lesion data (location, size, existence of ground-glass opacities [GGOs], pleural involvement, computed tomography [CT] bronchus sign, visibility on fluoroscopy, and EBUS findings); final diagnosis; years of bronchoscopist experience; and guide sheath size. Univariate and multivariate logistic regression analyses were performed. Results: Among the 916 patients, 30 (3.28%) presented with pneumothorax. With a univariate analysis, factors that independently predisposed to pneumothorax included lesions containing GGOs, lesions in sagittal lung segments on fluoroscopy, lesions that were not visible on fluoroscopy, and infectious lesions. A univariate analysis also showed that lesions in the right upper lobe or left upper division, as well as malignant lesions, were less likely to lead to pneumothorax. Age, underlying pulmonary disease, CT bronchus sign, EBUS findings, bronchoscopist experience, and guide sheath size did not influence the incidence of pneumothorax. A multivariate analysis revealed that only lesions containing GGOs (odds ratio [OR] 6.47; 95% confidence interval [CI] 2.13–19.6, P = 0.001) and lesions in lung segments with a sagittal orientation on fluoroscopy (OR 2.47; 95% CI 1.09–5.58, P = 0.029) were significant risk factors for EBUS-GS-TBB-related pneumothorax. Conclusions: EBUS-GS-TBB of lesions containing GGOs or lesions located in sagittal lung segments on fluoroscopy correlate with a higher pneumothorax risk.

DOI： 10.1186/s12890-021-01551-1

Prevalence of and factors associated with dilated choroidal vessels beneath the retinal pigment epithelium among the Japanese 査読有り Open Access

Ito, Y; Ito, M; Iwase, T; Kataoka, K; Yamada, K; Yasuda, S; Ito, H; Takeuchi, J; Nakano, Y; Fujita, A; Horiguchi, E; Taki, Y; Yatsuya, H; Terasaki, H

SCIENTIFIC REPORTS 11 巻 ( 1 ) 頁： 11278 2021年5月

記述言語：英語出版者・発行元：Scientific Reports

Pachyvessels are pathologically dilated large choroidal vessels and are associated with the pathogenesis of several pachychoroid-related disorders, including central serous chorioretinopathy. We aimed to investigate the prevalence of and risk factors for pachyvessels in the Japanese population. We included 316 participants (aged ≥ 40 years) with normal right eyes. The presence of pachyvessels (vertical diameter > 300 µm, distance to the retinal pigment epithelium < 50 µm) was determined using 6 × 6 mm macular swept-source optical coherence tomography images, and associated risk factors were investigated. Subfoveal choroidal thickness was measured, and its associated risk factors investigated. The overall prevalence of pachychoroids was 9.5%. Regression analysis showed that a younger age, shorter axial length, male sex, and smoking were significantly associated with the presence of pachyvessels (p = 0.047; odds ratio [OR] 0.96 per year, p = 0.021; OR 0.61 per 1 mm, p = 0.012; OR 3.08 vs. female, and p = 0.011; OR 3.15 vs. non-smoker, respectively) and greater choroidal thickness (p < 0.001, p < 0.001, p < 0.003, and p < 0.017, respectively). The results were consistent with other research findings which showed that pachychoroid-related disorders such as central serous chorioretinopathy were associated with younger age, male sex, shorter axial length, and smoking. Smoking may be associated with choroidal circulatory disturbance in the Japanese population.

DOI： 10.1038/s41598-021-90493-z

Inherited Chromosomally Integrated Human Herpesvirus 6 Is a Risk Factor for Spontaneous Abortion 査読有り国際誌

Miura, H; Kawamura, Y; Ohye, T; Hattori, F; Kozawa, K; Ihira, M; Yatsuya, H; Nishizawa, H; Kurahashi, H; Yoshikawa, T

JOURNAL OF INFECTIOUS DISEASES 223 巻 ( 10 ) 頁： 1717 - 1723 2021年5月

Perceptions and behaviors related to noncommunicable diseases in Palau: a qualitative study 査読有り Open Access

Shimizu, H; Hirakawa, Y; Chiang, C; Ngiralmau, B; Tellei, J; Rehuher-Marugg, FK; Mita, T; Yatsuya, H; Aoyama, A

NAGOYA JOURNAL OF MEDICAL SCIENCE 83 巻 ( 2 ) 頁： 287 - 298 2021年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nagoya Journal of Medical Science

The increasing burden of noncommunicable diseases (NCDs) is a major public health concern in Palau. This study aims to identify social and psychological factors related to NCDs among Palauan people using a qualitative approach. We conducted eight key informant interviews and eight focus group discussions, which were audio-recorded, transcribed and translated into English. Ideas of the respondents were extracted and labeled, and the labels were analyzed using an inductive multistage approach referred to as qualitative content analysis. Three themes emerged: (1) home education, (2) traditional local community, and (3) modernization and westernization of lifestyle. Respondents believed that the influence of the family on lifestyle was significant, but that disciplining children at home had become difficult. They considered that the traditional lifestyle was mostly healthy, and were reluctant to abandon certain unhealthy customs, such as serving abundant food to guests as a sign of fraternity. They also thought that they overate because of their stressful modernized lifestyle. This is the first qualitative study to analyze perception and behavior of the Palauan people in relation to NCDs. We found that the increase in NCDs was related to two concurrent trends: preserving certain traditional customs unfavorable to good health, and abandoning time-consuming healthy traditional lifestyle to adopt a modernized one. We also found that Palauan people were not confident in their ability to prevent NCDs. Therefore, health promotion activities should be designed to empower people to make positive changes.

DOI： 10.18999/nagjms.83.2.287

Weight change during middle age and risk of stroke and coronary heart disease: The Japan Public Health Center?based Prospective Study 査読有り国際誌

Kisanuki, K; Muraki, I; Yamagishi, K; Kokubo, Y; Saito, I; Yatsuya, H; Sawada, N; Iso, H; Tsugane, S

ATHEROSCLEROSIS 322 巻頁： 67 - 73 2021年4月

Avoid clinical inertia: Importance of asking and advising patients with diabetes who smoke about quitting 査読有り Open Access

Yatsuya, H

JOURNAL OF DIABETES INVESTIGATION 12 巻 ( 3 ) 頁： 317 - 319 2021年3月

Factors Associated With Prediabetes and Diabetes Among Public Employees in Northern Ethiopia 査読有り国際共著国際誌

He, YP; Chiang, CF; Gebremariam, LW; Hirakawa, Y; Yatsuya, H; Aoyama, A

ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH 33 巻 ( 2-3 ) 頁： 242 - 250 2021年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Asia Pacific Journal of Public Health

The increasing burden of diabetes mellitus is one of the major public health challenges in African countries, including Ethiopia. This is the first study aimed to identify factors associated with prediabetes and diabetes defined by both fasting blood glucose and glycated hemoglobin in Ethiopians. We analyzed data of a cross-sectional survey (1372 adults aged 25-64 years) conducted between October 2015 and February 2016; multinomial logistic regression models were applied. Abdominal obesity, total cholesterol, and non–high-density lipoprotein cholesterol were independently associated with prediabetes and diabetes in both sexes. Increased triglycerides and religious fasting practices were independently associated with prediabetes and diabetes only in men; hypertension was associated with prediabetes and diabetes only in women, while high-density lipoprotein cholesterol was not associated with prediabetes and diabetes in either sex. Sex differences in the association of triglycerides, hypertension, and dietary habit suggest that different approaches of lifestyle modification may be required for men and women.

DOI： 10.1177/1010539520974848

Determinants of alcohol consumption and marijuana use among young adults in the Republic of Palau 査読有り国際共著 Open Access

Sata, M; Cui, RZ; Chiang, CF; Singeo, ST ; Watson, BM; Yatsuya, H; Honjo, K; Mita, T; Temengil, EJ; Madraisau, S; Yamagishi, K; Aoyama, A; Iso, H

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE 26 巻 ( 1 ) 頁： 12 2021年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Environmental Health and Preventive Medicine

Background: This study aimed to describe the status of alcohol consumption and drug use among young adults as well as their determinants. Methods: We conducted a cross-sectional study of 356 young adults (aged 18 to 24 years) living in Palau in 2013. The prevalence of self-reported alcohol and marijuana usage were compared within and between sexes, age groups, ethnicities, and education levels. Results: The proportion of current drinking was higher in people aged 21–24 than in those aged 18–20 (73.2% vs. 60.9%, p = 0.09 in men and 48.3% vs. 30.0%, p = 0.02 in women), while that of marijuana use did not differ between the age groups. The proportions of current drinking and marijuana use were higher in Palauan than in other ethnicities (current drinking: 70.6% vs. 40.6%, p = 0.005 in men and 38.8% vs. 16.6%, p = 0.04 in women; lifetime marijuana use: 80.0% vs. 52.9%, p = 0.02 in men and 56.1% vs. 30.6%, p = 0.09 in women). The proportion of frequent (3 times or more) marijuana users was higher for the lower educated than for the higher educated (62.5% vs. 32.1%, p < 0.001 in men and 33.9% vs. 24.4%, p = 0.12 in women). Conclusions: Sex, age, ethnicity, and education were significant determinants of alcohol and marijuana use.

DOI： 10.1186/s12199-020-00928-8

その他リンク： http://link.springer.com/article/10.1186/s12199-020-00928-8/fulltext.html

Saif-Ur-Rahman, KM; Mamun, R; Li, YY; Matsunaga, M; Ota, A; Yatsuya, H

JOURNAL OF OCCUPATIONAL HEALTH 63 巻 ( 1 ) 頁： e12278 2021年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Occupational Health

Background: Diabetes is a major risk factor for cardiovascular diseases (CVD). This systematic review aims to explore the work-related factors among people with diabetes in developing CVD. Methods: Four electronic databases were searched on 1 February 2021 using a comprehensive search strategy without any time restriction. Two independent researchers screened the articles and extracted data. The risk of bias was assessed independently using the risk of bias assessment tool for non-randomized studies (RoBANS). A narrative synthesis was conducted considering the heterogeneity of the included articles. Results: A total of five articles incorporating 4 409 810 participants from three geographic regions were included that highlights the research gap. As per the included studies, Occupational drivers with diabetes were at a higher risk of CVD in comparison to the nondrivers, workers with diabetes having a long working hour were at a higher risk of CVD mortality, workers with a lower occupational status were at a higher risk of 10-years stroke risk, and occupational physical activity and occupational commuting lowered the risk of CVD deaths. Conclusions: This systematic review summarized the available evidence on work-related factors influencing the risk of CVD in people with diabetes. The findings should be interpreted cautiously pondering the limited evidence and imprecision. We identified only five articles related to the topic, and there were no studies from Japan. The scarcity of studies on work-related factors on the prognosis of diabetic patients implies the need for more research in this field. We recommend further exploration of the topic designing primary studies.

DOI： 10.1002/1348-9585.12278

その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/1348-9585.12278

Health of university students under job and financial insecurity during COVID-19 pandemic 招待有り Open Access

Yatsuya, H; Ishitake, T

JOURNAL OF OCCUPATIONAL HEALTH 63 巻 ( 1 ) 頁： e12223 2021年1月

一般的な代謝結果を予測するための人工ニューラルネットワークおよびロジスティック回帰の比較(Comparison of artificial neural network and logistic regression for predicting common metabolic outcomes)

He Yupeng, Chiang Chifa, Hirakawa Yoshihisa, Yatsuya Hiroshi

Journal of Epidemiology 31 巻 ( Suppl.1 ) 頁： 138 - 138 2021年1月

Apolipoprotein A2 Isoforms in Relation to the Risk of Myocardial Infarction: A Nested Case-Control Analysis in the JPHC Study 査読有り Open Access

Kihara, T; Yamagishi, K; Honda, K; Ikeda, A; Yatsuya, H; Saito, I; Kokubo, Y; Yamaji, T; Shimazu, T; Sawada, N; Iwasaki, M; Iso, H; Tsugane, S

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 28 巻 ( 5 ) 頁： 483 - 490 2021年

Estimation of 10-Year Risk of Death from Coronary Heart Disease, Stroke, and Cardiovascular Disease in a Pooled Analysis of Japanese Cohorts: EPOCH-JAPAN 査読有り Open Access

Li, YY; Yatsuya, H; Tanaka, S; Iso, H; Okayama, A; Tsuji, I; Sakata, K; Miyamoto, Y; Ueshima, H; Miura, K; Murakami, Y; Okamura, T

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 28 巻 ( 8 ) 頁： 816 - 825 2021年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Atherosclerosis and Thrombosis

Aims: We aimed to develop and validate risk prediction models to estimate the absolute 10-year risk of death from coronary heart disease (CHD), stroke, and cardiovascular disease (CVD). Methods: We evaluated a total of 44,869 individuals aged 40-79 years from eight Japanese prospective cohorts to derive coefficients of risk equations using cohort-stratified Cox proportional hazard regression models. Discrimination (C-index) of the equation was examined in each cohort and summarised using random-effect metaanalyses. Calibration of the equation was assessed using Hosmer-Lemeshow chi-squared statistic. Results: Within a median follow-up of 12.7 years, we observed 765 deaths due to CVD (276 CHDs and 489 strokes). After backward selection, age, sex, current smoking, systolic blood pressure (SBP), proteinuria, prevalent diabetes mellitus, the ratio of total cholesterol to high-density lipoprotein cholesterol (TC/HDLC), interaction terms of age by SBP, and age by current smoking were retained as predictors for CHD. Sex was excluded in the stroke equation. We did not consider TC/HDLC as a risk factor for the stroke and CVD equations. The pooled C-indices for CHD, stroke, and CVD were 0.83, 0.80, and 0.81, respectively, and the corresponding p-values of the Hosmer-Lemeshow tests were 0.18, 0.003, and 0.25, respectively. Conclusions: Risk equations in the present study can adequately estimate the absolute 10-year risk of death from CHD, stroke, and CVD. Future work will evaluate the system as an education and risk communication tool for primary prevention of CHD and stroke.

DOI： 10.5551/jat.58958

Pelvic exenteration associated with future renal dysfunction 査読有り

Sando, M; Uehara, K; Li, YY; Alba, T; Ogura, A; Ebata, T; Kodera, Y; Yatsuya, H; Nagino, M

SURGERY TODAY 50 巻 ( 12 ) 頁： 1601 - 1609 2020年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Surgery Today

Purpose: This study aimed to clarify the long-term change in the renal function after pelvic exenteration (PE) and to evaluate the risk factors for any future dysfunction. Methods: This study comprised 40 patients. A greater than 25% decline in the estimated glomerular filtration rate (eGFR) at 3 years was defined as early renal function disorder (ERFD), possibly predicting future chronic kidney disease (CKD). Results: In the entire cohort, the median eGFR decreased by 23% at 3 years, and CKD developed in 50%. The patients were divided into the ERFD (n = 16) and non-ERFD (n = 24) groups. In the ERFD group, the eGFR significantly decreased by 28% during the first 1.5 years and continued to decline after that, resulting in 81.3% of patients reaching CKD, whereas it was 4% and 37.5%, respectively, in the non-ERFD group. In a growth model analysis, late urinary tract complications (UTC) and small bowel obstruction were shown to be risk factors for ERFD. Conclusion: Although PE was associated with a high incidence of future CKD, ERFD could predict it. Close observation of the eGFR decline over 1.5 years might be beneficial to identify ERFD patients. High-risk patients with late UTC and small bowel obstruction should, therefore, be observed carefully.

DOI： 10.1007/s00595-020-02036-0

Increased risk of occupational trichloroethylene hypersensitivity syndrome at exposure levels higher than 15 mg/L of urinary trichloroacetic acid, regardless of whether the patients had the HLA-B*13:01 allele 査読有り国際共著国際誌

Wang, HL; Nakajima, T; Ito, Y; Naito, H; Zhao, N; Li, HL; Qiu, XX; Xia, LH; Chen, JB; Wu, QF; Li, LY; Huang, HL; Yanagiba, Y; Qu, HY; Yatsuya, H; Kamijima, M

ENVIRONMENTAL RESEARCH 191 巻頁： 109972 - 109972 2020年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Environmental Research

Occupational trichloroethylene (TCE) exposure can cause hypersensitivity syndrome (TCE-HS). The human leukocyte antigen (HLA)-B*13:01 is reportedly an important allele involved in TCE-HS onset. However, the threshold exposure level causing TCE-HS in relation to HLA-B*13:01 remains unknown. We conducted a case-control study comprising 37 TCE-HS patients and 97 age- and sex-matched TCE-tolerant controls from the Han Chinese population. Urine and blood of patients were collected on the first day of hospitalization, and those of controls were collected at the end of their shifts. Urinary trichloroacetic acid (TCA) was measured as an exposure marker, and end-of-shift levels in the patients were estimated using the biological half-life of 83.7 h. HLA-B genotype was identified using DNA from blood. Crude odds ratios (ORs) for TCE-HS in the groups with urinary TCA concentration >15 mg/L to ≤50 mg/L and of >50 mg/L were 21.9 [95% confidence interval (CI) 4.2–114.1] and 27.6 (6.1–125.8), respectively, when the group with urinary TCA ≤15 mg/L was used as a reference. The frequency of HLA-B*13:01, the most common allele in the patients, was 62.2% (23/37), which was significantly higher than 17.5% (17/97) in the TCE-tolerant controls, with a crude OR of 8.4 (3.1–22.6). The mutually-adjusted ORs for urinary TCA >15 to ≤50 mg/L, >50 mg/L, and for HLA-B*13:01 were 33.4 (4.1–270.8), 34.0 (5.3–217.1), and 11.0 (2.4–50.7), respectively. In conclusion, reduction of TCE exposure to ≤15 mg/L is required for TCE-HS prevention because urinary TCA concentration >15 mg/L showed increased risk of TCE-HS, regardless of whether the patients had the HLA-B*13:01 allele.

DOI： 10.1016/j.envres.2020.109972

Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study 査読有り国際共著 Open Access

Roth G.A., Mensah G.A., Johnson C.O., Addolorato G., Ammirati E., Baddour L.M., Barengo N.C., Beaton A., Benjamin E.J., Benziger C.P., Bonny A., Brauer M., Brodmann M., Cahill T.J., Carapetis J.R., Catapano A.L., Chugh S., Cooper L.T., Coresh J., Criqui M.H., DeCleene N.K., Eagle K.A., Emmons-Bell S., Feigin V.L., Fernández-Sola J., Fowkes F.G.R., Gakidou E., Grundy S.M., He F.J., Howard G., Hu F., Inker L., Karthikeyan G., Kassebaum N.J., Koroshetz W.J., Lavie C., Lloyd-Jones D., Lu H.S., Mirijello A., Misganaw A.T., Mokdad A.H., Moran A.E., Muntner P., Narula J., Neal B., Ntsekhe M., Oliveira G.M.M., Otto C.M., Owolabi M.O., Pratt M., Rajagopalan S., Reitsma M.B., Ribeiro A.L.P., Rigotti N.A., Rodgers A., Sable C.A., Shakil S.S., Sliwa K., Stark B.A., Sundström J., Timpel P., Tleyjeh I.I., Valgimigli M., Vos T., Whelton P.K., Yacoub M., Zuhlke L.J., Abbasi-Kangevari M., Abdi A., Abedi A., Aboyans V., Abrha W.A., Abu-Gharbieh E., Abushouk A.I., Acharya D., Adair T., Adebayo O.M., Ademi Z., Advani S.M., Afshari K., Afshin A., Agarwal G., Agasthi P., Ahmad S., Ahmadi S., Ahmed M.B., Aji B., Akalu Y., Akande-Sholabi W., Aklilu A., Akunna C.J., Alahdab F., Al-Eyadhy A., Alhabib K.F., Alif S.M., Alipour V., Aljunid S.M., Alla F., Almasi-Hashiani A., Almustanyir S.

Journal of the American College of Cardiology 76 巻 ( 25 ) 頁： 2982 - 3021 2020年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of the American College of Cardiology

Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019. Prevalent cases of total CVD nearly doubled from 271 million (95% uncertainty interval [UI]: 257 to 285 million) in 1990 to 523 million (95% UI: 497 to 550 million) in 2019, and the number of CVD deaths steadily increased from 12.1 million (95% UI:11.4 to 12.6 million) in 1990, reaching 18.6 million (95% UI: 17.1 to 19.7 million) in 2019. The global trends for disability-adjusted life years (DALYs) and years of life lost also increased significantly, and years lived with disability doubled from 17.7 million (95% UI: 12.9 to 22.5 million) to 34.4 million (95% UI:24.9 to 43.6 million) over that period. The total number of DALYs due to IHD has risen steadily since 1990, reaching 182 million (95% UI: 170 to 194 million) DALYs, 9.14 million (95% UI: 8.40 to 9.74 million) deaths in the year 2019, and 197 million (95% UI: 178 to 220 million) prevalent cases of IHD in 2019. The total number of DALYs due to stroke has risen steadily since 1990, reaching 143 million (95% UI: 133 to 153 million) DALYs, 6.55 million (95% UI: 6.00 to 7.02 million) deaths in the year 2019, and 101 million (95% UI: 93.2 to 111 million) prevalent cases of stroke in 2019. Cardiovascular diseases remain the leading cause of disease burden in the world. CVD burden continues its decades-long rise for almost all countries outside high-income countries, and alarmingly, the age-standardized rate of CVD has begun to rise in some locations where it was previously declining in high-income countries. There is an urgent need to focus on implementing existing cost-effective policies and interventions if the world is to meet the targets for Sustainable Development Goal 3 and achieve a 30% reduction in premature mortality due to noncommunicable diseases.

DOI： 10.1016/j.jacc.2020.11.010

Inherited chromosomally integrated human herpesvirus 6 and autoimmune connective tissue diseases 査読有り国際誌

Kawamura, Y; Hashimoto, T; Miura, H; Kozawa, K; Yoshikawa, A; Ikeda, N; Yatsuya, H; Yasuoka, H; Yoshikawa, T

JOURNAL OF CLINICAL VIROLOGY 132 巻頁： 104656 - 104656 2020年11月

Positive Association of Physical Activity with Both Objective and Perceived Measures of the Neighborhood Environment among Older Adults: The Aichi Workers' Cohort Study 査読有り国際誌 Open Access

Li, YY; Yatsuya, H; Hanibuchi, T; Ota, A; Naito, H; Otsuka, R; Murata, C; Hirakawa, Y; Chiang, CF; Uemura, M; Tamakoshi, K; Aoyama, A

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 17 巻 ( 21 ) 頁： 1 - 14 2020年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Environmental Research and Public Health

We examined the association between objective and perceived neighborhood characteristics and self-reported leisure-time physical activity (PA) in older Japanese residents living in areas ranging from metropolitan to rural in 2016. Objective measures used were walkability and the numbers of parks/green spaces and sports facilities within 500 or 1000 m of subjects’ homes, calculated using geographic information systems. Subjective measures were the subjects’ perceptions of their neighborhoods, assessed using a structured questionnaire. All variables were divided into three groups, and the lowest tertile was used as the reference. We assessed the location and frequency of strolling or brisk walking, moderate-intensity PA, and vigorous-intensity PA (sports) using a self-reported questionnaire and defined as performing a certain type of PA 3–4 times/week as a habit. Living in a neighborhood in the highest tertile for walkability and number of parks/green spaces as well as perception of having good access to recreational facilities, observing others exercising and the presence of walkable sidewalks was associated with walking and sports habits (multivariable odds ratios (ORs): 1.33–2.46, all p < 0.05). Interestingly, objective measures of PA-friendly environmental features were inversely associated with moderate-intensity PA habits, potentially because moderate-intensity PA consisted predominantly of gardening. In conclusion, living in an environment supportive of PA, whether objectively or subjectively measured, is related to leisure-time PA habits among older Japanese adults.

DOI： 10.3390/ijerph17217971

Incorporating kidney disease measures into cardiovascular risk prediction: Development and validation in 9 million adults from 72 datasets 査読有り国際共著国際誌 Open Access

Matsushita, K; Jassal, SK; Sang, YY; Ballew, SH; Grams, ME; Surapaneni, A; Arnlov, J; Bansal, N; Bozic, M; Brenner, H; Brunskill, NJ; Chang, AR; Chinnadurai, R; Cirillo, M; Correa, A; Ebert, N; Eckardt, KU; Gansevoort, RT; Gutierrez, O; Hadaegh, F; He, J; Hwang, SJ; Jafar, TH; Kayama, T; Kovesdy, CP; Landman, GW; Levey, AS; Lloyd-Jones, DM; Major, RW; Miura, K; Muntner, P; Nadkarni, GN; Naimark, DM; Nowak, C; Ohkubo, T; Pena, MJ; Polkinghorne, KR; Sabanayagam, C; Sairenchi, T; Schneider, MP; Shalev, V; Shlipak, M; Solbu, MD; Stempniewicz, N; Tollitt, J; Valdivielso, JM; van der Leeuw, J; Wang, AYM; Wen, CP; Woodward, M; Yamagishi, K; Yatsuya, H; Zhang, LX; Schaeffner, E; Coresh, J

ECLINICALMEDICINE 27 巻頁： 100552 - 100552 2020年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Eclinicalmedicine

Background: Chronic kidney disease (CKD) measures (estimated glomerular filtration rate [eGFR] and albuminuria) are frequently assessed in clinical practice and improve the prediction of incident cardiovascular disease (CVD), yet most major clinical guidelines do not have a standardized approach for incorporating these measures into CVD risk prediction. “CKD Patch” is a validated method to calibrate and improve the predicted risk from established equations according to CKD measures. Methods: Utilizing data from 4,143,535 adults from 35 datasets, we developed several “CKD Patches” incorporating eGFR and albuminuria, to enhance prediction of risk of atherosclerotic CVD (ASCVD) by the Pooled Cohort Equation (PCE) and CVD mortality by Systematic COronary Risk Evaluation (SCORE). The risk enhancement by CKD Patch was determined by the deviation between individual CKD measures and the values expected from their traditional CVD risk factors and the hazard ratios for eGFR and albuminuria. We then validated this approach among 4,932,824 adults from 37 independent datasets, comparing the original PCE and SCORE equations (recalibrated in each dataset) to those with addition of CKD Patch. Findings: We confirmed the prediction improvement with the CKD Patch for CVD mortality beyond SCORE and ASCVD beyond PCE in validation datasets (Δc-statistic 0.027 [95% CI 0.018–0.036] and 0.010 [0.007–0.013] and categorical net reclassification improvement 0.080 [0.032–0.127] and 0.056 [0.044–0.067], respectively). The median (IQI) of the ratio of predicted risk for CVD mortality with CKD Patch vs. the original prediction with SCORE was 2.64 (1.89–3.40) in very high-risk CKD (e.g., eGFR 30–44 ml/min/1.73m2 with albuminuria ≥30 mg/g), 1.86 (1.48–2.44) in high-risk CKD (e.g., eGFR 45–59 ml/min/1.73m2 with albuminuria 30–299 mg/g), and 1.37 (1.14–1.69) in moderate risk CKD (e.g., eGFR 60–89 ml/min/1.73m2 with albuminuria 30–299 mg/g), indicating considerable risk underestimation in CKD with SCORE. The corresponding estimates for ASCVD with PCE were 1.55 (1.37–1.81), 1.24 (1.10–1.54), and 1.21 (0.98–1.46). Interpretation: The “CKD Patch” can be used to quantitatively enhance ASCVD and CVD mortality risk prediction equations recommended in major US and European guidelines according to CKD measures, when available. Funding: US National Kidney Foundation and the NIDDK.

DOI： 10.1016/j.eclinm.2020.100552

The Smart Life Stay (SLS) program: effects of a lifestyle intervention program in combination with health tourism and health guidance for type 2 diabetes (vol 10, 33, 2020) 査読有り国際誌 Open Access

Matsushita, M; Muramoto, A; Nomura, E; Eguchi, Y; Kato, A; Sano, Y; Kabayama, M; Arakawa, M; Oguma, Y; Yabe, D; Matsunaga, M; Yatsuya, H; Arima, H; Tsushita, K

NUTRITION & DIABETES 10 巻 ( 1 ) 頁： 34 - 34 2020年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nutrition and Diabetes

Following publication, the authors asked to add the following institution to the affiliations of author Madoka Matsushita: Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine Both the PDF and HTML versions of the Article have been updated accordingly.

DOI： 10.1038/s41387-020-00137-w

Risk and population attributable fraction of metabolic syndrome and impaired fasting glucose for the incidence of type 2 diabetes mellitus among middle-aged Japanese individuals: Aichi Worker's Cohort Study 査読有り Open Access

Kaneko, K; Yatsuya, H; Li, YY; Uemura, M; Chiang, CF; Hirakawa, Y; Ota, A; Tamakoshi, K; Aoyama, A

JOURNAL OF DIABETES INVESTIGATION 11 巻 ( 5 ) 頁： 1163 - 1169 2020年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Diabetes Investigation

Aims/Introduction: The Japanese government started a nationwide screening program for metabolic syndrome (MetS) to prevent cardiovascular diseases and diabetes in 2008. Although impaired fasting glucose (IFG) is a strong predictor for type 2 diabetes mellitus, the program does not follow up IFG in non-MetS individuals. This study aimed to examine the risk and the population attributable fraction (PAF) of MetS and IFG for incidence of type 2 diabetes mellitus. Materials and Methods: Japanese workers (3,417 men and 714 women) aged 40–64 years without a history of diabetes were prospectively followed. MetS was defined as either abdominal obesity plus two or more metabolic risk factors, or being overweight in the case of normal waist circumference plus three or more metabolic risk factors. IFG was defined as fasting blood glucose 100–125 mg/dL. Results: During a mean 6.3 years, 240 type 2 diabetes mellitus cases were identified. Compared with those without MetS and IFG, the multivariable-adjusted hazard ratios (95% confidence interval) of non-MetS individuals with IFG, MetS individuals without IFG and MetS individuals with IFG for type 2 diabetes mellitus were 4.9 (3.4–7.1), 2.4 (1.6–3.5) and 8.3 (5.9–11.5), respectively. The corresponding PAFs for type 2 diabetes mellitus incidence were 15.6, 9.1 and 29.7%, respectively. Conclusions: IFG represented a higher risk and PAF than MetS for type 2 diabetes mellitus incidence in middle-aged Japanese individuals. The coexistence of MetS and IFG showed the highest risk and PAF for type 2 diabetes mellitus incidence. The current Japanese MetS screening program should be reconsidered to follow up non-MetS individuals with IFG.

DOI： 10.1111/jdi.13230

Milk Intake and Stroke Mortality in the Japan Collaborative Cohort Study-A Bayesian Survival Analysis 査読有り国際共著国際誌 Open Access

Wang, CC; Yatsuya, H; Lin, YS; Sasakabe, T; Kawai, S; Kikuchi, S; Iso, H; Tamakoshi, A

NUTRIENTS 12 巻 ( 9 ) 2020年9月

Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17 査読有り国際共著国際誌

Deshpande Aniruddha, Miller-Petrie Molly K., Lindstedt Paulina A., Baumann Mathew M., Johnson Kimberly B., Blacker Brigette F., Abbastabar Hedayat, Abd-Allah Foad, Abdelalim Ahmed, Abdollahpour Ibrahim, Abegaz Kedir Hussein, Abejie Ayenew Negesse, Abreu Lucas Guimaraes, Abrigo Michael R. M., Abualhasan Ahmed, Accrombessi Manfred Mario Kokou, Adamu Abdu A., Adebayo Oladimeji M., Adedeji Isaac Akinkunmi, Adedoyin Rufus Adesoji, Adekanmbi Victor, Adetokunboh Olatunji O., Adhikari Tara Ballav, Afarideh Mohsen, Agudelo-Botero Marcela, Ahmadi Mehdi, Ahmadi Keivan, Ahmed Muktar Beshir, Ahmed Anwar E., Akalu Temesgen Yihunie, Akanda Ali S., Alahdab Fares, Al-Aly Ziyad, Alam Samiah, Alam Noore, Alamene Genet Melak, Alanzi Turki M., Albright James, Albujeer Ammar, Alcalde-Rabanal Jacqueline Elizabeth, Alebel Animut, Alemu Zewdie Aderaw, Ali Muhammad, Alijanzadeh Mehran, Alipour Vahid, Aljunid Syed Mohamed, Almasi Ali, Almasi-Hashiani Amir, Al-Mekhlafi Hesham M., Altirkawi Khalid A., Alvis-Guzman Nelson, Alvis-Zakzuk Nelson J., Amini Saeed, Amit Arianna Maever L., Amul Gianna Gayle Herrera, Andrei Catalina Liliana, Anjomshoa Mina, Ansariadi Ansariadi, Antonio Carl Abelardo T., Antony Benny, Antriyandarti Ernoiz, Arabloo Jalal, Aref Hany Mohamed Amin, Aremu Olatunde, Armoon Bahram, Arora Amit, Aryal Krishna K., Arzani Afsaneh, Asadi-Aliabadi Mehran, Asmelash Daniel, Atalay Hagos Tasew, Athari Seyyede Masoume, Athari Seyyed Shamsadin, Atre Sachin R., Ausloos Marcel, Awasthi Shally, Awoke Nefsu, Quintanilla Beatriz Paulina Ayala, Ayano Getinet, Ayanore Martin Amogre, Aynalem Yared Asmare, Azari Samad, Azman Andrew S., Babaee Ebrahim, Badawi Alaa, Bagherzadeh Mojtaba, Bakkannavar Shankar M., Balakrishnan Senthilkumar, Banach Maciej, Banoub Joseph Adel Mattar, Barac Aleksandra, Barboza Miguel A., Barnighausen Till Winfried, Basu Sanjay, Vo Dinh Bay, Bayati Mohsen, Bedi Neeraj, Beheshti Mahya, Behzadifar Meysam, Behzadifar Masoud, Ramirez Diana Fernanda Bejarano, Bell Michelle L., Bennett Derrick A., Benzian Habib, Berbada Dessalegn Ajema, Bernstein Robert S., Bhat Anusha Ganapati, Bhattacharyya Krittika, Bhaumik Soumyadeep, Bhutta Zulfiqar A., Bijani Ali, Bikbov Boris, Bin Sayeed Muhammad Shahdaat, Biswas Raaj Kishore, Bohlouli Somayeh, Boufous Soufiane, Brady Oliver J., Briko Andrey Nikolaevich, Briko Nikolay Ivanovich, Britton Gabrielle B., Brown Alexandria, Nagaraja Sharath Burugina, Butt Zahid A., Camera Luis Alberto, Campos-Nonato Ismael R., Rincon Julio Cesar Campuzano, Cano Jorge, Car Josip, Cardenas Rosario, Carvalho Felix, Castaneda-Orjuela Carlos A., Castro Franz, Cerin Ester, Chalise Binaya, Chattu Vijay Kumar, Chin Ken Lee, Christopher Devasahayam J., Chu Dinh-Toi, Cormier Natalie Maria, Costa Vera Marisa, Cromwell Elizabeth A., Dadi Abel Fekadu Fekadu, Dahiru Tukur, Dahlawi Saad M. A., Dandona Rakhi, Dandona Lalit, Dang Anh Kim, Daoud Farah, Darwesh Aso Mohammad, Darwish Amira Hamed, Daryani Ahmad, Das Jai K., Das Gupta Rajat, Dash Aditya Prasad, Davila-Cervantes Claudio Alberto, Weaver Nicole Davis, De la Hoz Fernando Pio, De Neve Jan-Walter, Demissie Dereje Bayissa, Demoz Gebre Teklemariam, Denova-Gutierrez Edgar, Deribe Kebede, Desalew Assefa, Dharmaratne Samath Dhamminda, Dhillon Preeti, Dhimal Meghnath, Dhungana Govinda Prasad, Diaz Daniel, Dipeolu Isaac Oluwafemi, Hoa Thi, Dolecek Christiane, Doyle Kerrie E., Dubljanin Eleonora, Duraes Andre Rodrigues, Edinur Hisham Atan, Effiong Andem, Eftekhari Aziz, El Nahas Nevine, Zaki Maysaa El Sayed, El Tantawi Maha, Elhabashy Hala Rashad, El-Jaafary Shaimaa I, El-Khatib Ziad, Elkout Hajer, Elsharkawy Aisha, Enany Shymaa, Endalew Daniel Adane, Eshrati Babak, Eskandarieh Sharareh, Etemadi Arash, Ezekannagha Oluchi, Faraon Emerito Jose A., Fareed Mohammad, Faro Andre, Farzadfar Farshad, Fasil Alebachew Fasil, Fazlzadeh Mehdi, Feigin Valery L., Fekadu Wubalem, Fentahun Netsanet, Fereshtehnejad Seyed-Mohammad, Fernandes Eduarda, Filip Irina, Fischer Florian, Flohr Carsten, Foigt Nataliya A., Folayan Morenike Oluwatoyin, Foroutan Masoud, Franklin Richard Charles, Frostad Joseph Jon, Fukumoto Takeshi, Gad Mohamed M., Garcia Gregory M., Gatotoh Augustine Mwangi, Gayesa Reta Tsegaye, Gebremedhin Ketema Bizuwork, Geramo Yilma Chisha Dea, Gesesew Hailay Abrha, Gezae Kebede Embaye, Ghashghaee Ahmad, Sherbaf Farzaneh Ghazi, Gill Tiffany K., Gill Paramjit Singh, Ginindza Themba G., Girmay Alem, Gizaw Zemichael, Goodridge Amador, Gopalani Sameer Vali, Goulart Barbara Niegia Garcia, Goulart Alessandra C., Grada Ayman, Green Manfred S., Gubari Mohammed Ibrahim Mohialdeen, Gugnani Harish Chander, Guido Davide, Guimaraes Rafael Alves, Guo Yuming, Gupta Rajeev, Gupta Rahul, Ha Giang Hai, Haagsma Juanita A., Hafezi-Nejad Nima, Haile Dessalegn H., Haile Michael Tamene, Hall Brian J., Hamidi Samer, Handiso Demelash Woldeyohannes, Haririan Hamidreza, Hariyani Ninuk, Hasaballah Ahmed I, Hasan Mehedi, Hasanzadeh Amir, Hassen Hamid Yimam, Hayelom Desta Haftu, Hegazy Mohamed I, Heibati Behzad, Heidari Behnam, Hendrie Delia, Henok Andualem, Herteliu Claudiu, Heydarpour Fatemeh, de Hidru Hagos Degefa, Hird Thomas R., Chi Linh Hoang, Hollerich Gillian I, Hoogar Praveen, Hossain Naznin, Hosseinzadeh Mehdi, Househ Mowafa, Hu Guoqing, Humayun Ayesha, Hussain Syed Ather, Hussen Mamusha Aman A., Ibitoye Segun Emmanuel, Ilesanmi Olayinka Stephen, Ilic Milena D., Imani-Nasab Mohammad Hasan, Iqbal Usman, Irvani Seyed Sina Naghibi, Islam Sheikh Mohammed Shariful, Ivers Rebecca Q., Iwu Chinwe Juliana, Jahanmehr Nader, Jakovljevic Mihajlo, Jalali Amir, Jayatilleke Achala Upendra, Jenabi Ensiyeh, Jha Ravi Prakash, Jha Vivekanand, Ji John S., Jonas Jost B., Jozwiak Jacek Jerzy, Kabir Ali, Kabir Zubair, Kanchan Tanuj, Karch Andre, Karki Surendra, Kasaeian Amir, Kasahun Gebremicheal Gebreslassie, Kasaye Habtamu Kebebe, Kassa Gebrehiwot G., Kassa Getachew Mullu, Kayode Gbenga A., Kebede Mihiretu M., Keiyoro Peter Njenga, Ketema Daniel Bekele, Khader Yousef Saleh, Khafaie Morteza Abdullatif, Khalid Nauman, Khalilov Rovshan, Khan Ejaz Ahmad, Khan Junaid, Khan Nuruzzaman, Khatab Khaled, Khater Mona M., Khater Amir M., Khayamzadeh Maryam, Khazaei Mohammad, Khosravi Mohammad Hossein, Khubchandani Jagdish, Kiadaliri Ali, Kim Yun Jin, Kimokoti Ruth W., Kisa Sezer, Kisa Adnan, Kochhar Sonali, Kolola Tufa, Komaki Hamidreza, Kosen Soewarta, Koul Parvaiz A., Koyanagi Ai, Krishan Kewal, Defo Barthelemy Kuate, Kugbey Nuworza, Kumar Pushpendra, Kumar G. Anil, Kumar Manasi, Kusuma Dian, La Vecchia Carlo, Lacey Ben, Lal Aparna, Lal Dharmesh Kumar, Lam Hilton, Lami Faris Hasan, Lansingh Van Charles, Lasrado Savita, Lebedev Georgy, Lee Paul H., LeGrand Kate E., Leili Mostafa, Lenjebo Tsegaye Lolaso, Leshargie Cheru Tesema, Levine Aubrey J., Lewycka Sonia, Li Shanshan, Linn Shai, Liu Shiwei, Lopez Jaifred Christian F., Lopukhov Platon D., Abd El Razek Muhammed Magdy, Prasad D. R. Mahadeshwara, Mahasha Phetole Walter, Mahotra Narayan B., Majeed Azeem, Malekzadeh Reza, Malta Deborah Carvalho, Mamun Abdullah A., Manafi Navid, Mansournia Mohammad Ali, Mapoma Chabila Christopher, Martinez Gabriel, Martini Santi, Martins-Melo Francisco Rogerlandio, Mathur Manu Raj, Mayala Benjamin K., Mazidi Mohsen, McAlinden Colm, Meharie Birhanu Geta, Mehndiratta Man Mohan, Nasab Entezar Mehrabi, Mehta Kala M., Mekonnen Teferi, Mekonnen Tefera Chane, Meles Gebrekiros Gebremichael, Meles Hagazi Gebre, Memiah Peter T. N., Memish Ziad A., Mendoza Walter, Menezes Ritesh G., Mereta Seid Tiku, Meretoja Tuomo J., Mestrovic Tomislav, Metekiya Workua Mekonnen, Miazgowski Bartosz, Miller Ted R., Mini G. K., Mirrakhimov Erkin M., Moazen Babak, Mohajer Bahram, Mohammad Yousef, Mohammad Dara K., Mezerji Naser Mohammad Gholi, Mohammadibakhsh Roghayeh, Mohammed Shafiu, Mohammed Jemal Abdu, Mohammed Hassen, Mohebi Farnam, Mokdad Ali H., Moodley Yoshan, Moradi Masoud, Moradi Ghobad, Moradi-Joo Mohammad, Moraga Paula, Morales Linda, Mosapour Abbas, Mosser Jonathan F., Mouodi Simin, Mousavi Seyyed Meysam, Mozaffor Miliva, Munro Sandra B., Muriithi Moses K., Murray Christopher J. L., Musa Kamarul Imran, Mustafa Ghulam, Muthupandian Saravanan, Naderi Mehdi, Nagarajan Ahamarshan Jayaraman, Naghavi Mohsen, Naik Gurudatta, Nangia Vinay, Nascimento Bruno Ramos, Nazari Javad, Ndwandwe Duduzile Edith, Negoi Ionut, Netsere Henok Biresaw, Ngunjiri Josephine W., Cuong Tat Nguyen, Huong Lan Thi Nguyen, Nguyen QuynhAnh P., Nigatu Solomon Gedlu, Ningrum Dina Nur Anggraini, Nnaji Chukwudi A., Nojomi Marzieh, Norheim Ole F., Noubiap Jean Jacques, Oancea Bogdan, Ogbo Felix Akpojene, Oh In-Hwan, Olagunju Andrew T., Olusanya Jacob Olusegun, Olusanya Bolajoko Olubukunola, Onwujekwe Obinna E., Ortega-Altamirano Doris V, Osarenotor Osayomwanbo, Osei Frank B., Owolabi Mayowa O., Mahesh P. A., Padubidri Jagadish Rao, Pakhale Smita, Pana Adrian, Park Eun-Kee, Patel Sangram Kishor, Pathak Ashish, Patle Ajay, Paulos Kebreab, Pepito Veincent Christian Filipino, Perico Norberto, Pervaiz Aslam, Pescarini Julia Moreira, Pesudovs Konrad, Pham Hai Quang, Pigott David M., Pilgrim Thomas, Pirsaheb Meghdad, Poljak Mario, Pollock Ian, Postma Maarten J., Pourmalek Farshad, Pourshams Akram, Prada Sergio I, Preotescu Liliana, Quintana Hedley, Rabiee Navid, Rabiee Mohammad, Radfar Amir, Rafiei Alireza, Rahim Fakher, Rahimi Siavash, Rahimi-Movaghar Vafa, Rahman Muhammad Aziz, Rahman Mohammad Hifz Ur, Rajati Fatemeh, Ranabhat Chhabi Lal, Rao Puja C., Rasella Davide, Rath Goura Kishor, Rawaf Salman, Rawal Lal, Rawasia Wasiq Faraz, Remuzzi Giuseppe, Renjith Vishnu, Renzaho Andre M. N., Resnikoff Serge, Riahi Seyed Mohammad, Ribeiro Ana Isabel, Rickard Jennifer, Roever Leonardo, Ronfani Luca, Rubagotti Enrico, Rubino Salvatore, Saad Anas M., Sabour Siamak, Sadeghi Ehsan, Moghaddam Sahar Saeedi, Safari Yahya, Sagar Rajesh, Sahraian Mohammad Ali, Sajadi S. Mohammad, Salahshoor Mohammad Reza, Salam Nasir, Saleem Ahsan, Salem Hosni, Salem Marwa Rashad, Salimi Yahya, Salimzadeh Hamideh, Samy Abdallah M., Sanabria Juan, Santos Itamar S., Santric-Milicevic Milena M., Sao Jose Bruno Piassi, Saraswathy Sivan Yegnanarayana Iyer, Sarrafzadegan Nizal, Sartorius Benn, Sathian Brijesh, Sathish Thirunavukkarasu, Satpathy Maheswar, Sawhney Monika, Sayyah Mehdi, Sbarra Alyssa N., Schaeffer Lauren E., Schwebel David C., Senbeta Anbissa Muleta, Senthilkumaran Subramanian, Sepanlou Sadaf G., Servan-Mori Edson, Shafieesabet Azadeh, Shaheen Amira A., Shahid Izza, Shaikh Masood Ali, Shalash Ali S., Shams-Beyranvand Mehran, Shamsi MohammadBagher, Shamsizadeh Morteza, Shannawaz Mohammed, Sharafi Kiomars, Sharma Rajesh, Sheikh Aziz, Shetty B. Suresh Kumar, Shiferaw Wondimeneh Shibabaw, Shigematsu Mika, Shin Jae Il, Shiri Rahman, Shirkoohi Reza, Shivakumar K. M., Si Si, Siabani Soraya, Siddiqi Tariq Jamal, Silva Diego Augusto Santos, Singh Virendra, Singh Narinder Pal, Singh Balbir Bagicha Singh, Singh Jasvinder A., Singh Ambrish, Sinha Dhirendra Narain, Sisay Malede Mequanent, Skiadaresi Eirini, Smith David L., Filho Adauto Martins Soares, Sobhiyeh Mohammad Reza, Sokhan Anton, Soriano Joan B., Sorrie Muluken Bekele, Soyiri Ireneous N., Spurlock Emma Elizabeth, Sreeramareddy Chandrashekhar T., Sudaryanto Agus, Sufiyan Mu'awiyyah Babale, Suleria Hafiz Ansar Rasul, Sykes Bryan L., Tabares-Seisdedos Rafael, Tabuchi Takahiro, Tadesse Degena Bahrey, Tarigan Ingan Ukur, Taye Bineyam, Tefera Yonatal Mesfin, Tehrani-Banihashemi Arash, Tekelemedhin Shishay Wahdey, Tekle Merhawi Gebremedhin, Temsah Mohamad-Hani, Tesfay Berhe Etsay, Tesfay Fisaha Haile, Tessema Zemenu Tadesse, Thankappan Kavumpurathu Raman, ThekkePurakkal Akhil Soman, Thomas Nihal, Thompson Robert L., Thomson Alan J., Topor-Madry Roman, Tovani-Palone Marcos Roberto, Traini Eugenio, Bach Xuan Tran, Khanh Bao Tran, Ullah Irfan, Unnikrishnan Bhaskaran, Usman Muhammad Shariq, Uthman Olalekan A., Uzochukwu Benjamin S. Chudi, Valdez Pascual R., Varughese Santosh, Veisani Yousef, Violante Francesco S., Vollmer Sebastian, Whawariat Feleke Gebremeskel, Waheed Yasir, Wallin Mitchell Taylor, Wang Yuan-Pang, Wang Yafeng, Wangdi Kinley, Weiss Daniel J., Weldesamuel Girmay Teklay, Werkneh Adhena Ayaliew, Westerman Ronny, Wiangkham Taweewat, Wiens Kirsten E., Wijeratne Tissa, Wiysonge Charles Shey, Wolde Haileab Fekadu, Wondafrash Dawit Zewdu, Wonde Tewodros Eshete, Worku Getasew Taddesse, Yadollahpour Ali, Jabbari Seyed Hossein Yahyazadeh, Yamada Tomohide, Yaseri Mehdi, Yatsuya Hiroshi, Yeshaneh Alex, Yilma Mekdes Tigistu, Yip Paul, Yisma Engida, Yonemoto Naohiro, Younis Mustafa Z., Yousof Hebat-Allah Salah A., Yu Chuanhua, Yusefzadeh Hasan, Zadey Siddhesh, Moghadam Telma Zahirian, Zaidi Zoubida, Bin Zaman Sojib, Zamani Mohammad, Zandian Hamed, Zar Heather J., Zerfu Taddese Alemu, Zhang Yunquan, Ziapour Arash, Zodpey Sanjay, Zuniga Yves Miel H., Hay Simon I, Reiner Robert C. Jr.

LANCET GLOBAL HEALTH 8 巻 ( 9 ) 頁： E1162 - E1185 2020年9月

Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17 査読有り国際共著

Aniruddha Deshpande, Molly K. Miller-Petrie, Paulina A. Lindstedt, Mathew M. Baumann, Kimberly B. Johnson, Brigette F. Blacker, Hedayat Abbastabar, Foad Abd-Allah, Ahmed Abdelalim, Ibrahim Abdollahpour, Kedir Hussein Abegaz, Ayenew Negesse Abejie, Lucas Guimaraes Abreu, Michael R. M. Abrigo, Ahmed Abualhasan, Manfred Mario Kokou Accrombessi, Abdu A. Adamu, Oladimeji M. Adebayo, Isaac Akinkunmi Adedeji, Rufus Adesoji Adedoyin, Victor Adekanmbi, Olatunji O. Adetokunboh, Tara Ballav Adhikari, Mohsen Afarideh, Marcela Agudelo-Botero, Mehdi Ahmadi, Keivan Ahmadi, Muktar Beshir Ahmed, Anwar E. Ahmed, Temesgen Yihunie Akalu, Ali S. Akanda, Fares Alahdab, Ziyad Al-Aly, Samiah Alam, Noore Alam, Genet Melak Alamene, Turki M. Alanzi, James Albright, Ammar Albujeer, Jacqueline Elizabeth Alcalde-Rabanal, Animut Alebel, Zewdie Aderaw Alemu, Muhammad Ali, Mehran Alijanzadeh, Vahid Alipour, Syed Mohamed Aljunid, Ali Almasi, Amir Almasi-Hashiani, Hesham M. Al-Mekhlafi, Khalid A. Altirkawi, Nelson Alvis-Guzman, Nelson J. Alvis-Zakzuk, Saeed Amini, Arianna Maever L. Amit, Gianna Gayle Herrera Amul, Catalina Liliana Andrei, Mina Anjomshoa, Ansariadi Ansariadi, Carl Abelardo T. Antonio, Benny Antony, Ernoiz Antriyandarti, Jalal Arabloo, Hany Mohamed Amin Aref, Olatunde Aremu, Bahram Armoon, Amit Arora, Krishna K. Aryal, Afsaneh Arzani, Mehran Asadi-Aliabadi, Daniel Asmelash, Hagos Tasew Atalay, Seyyede Masoume Athari, Seyyed Shamsadin Athari, Sachin R. Atre, Marcel Ausloos, Shally Awasthi, Nefsu Awoke, Beatriz Paulina Ayala Quintanilla, Getinet Ayano, Martin Amogre Ayanore, Yared Asmare Aynalem, Samad Azari, Andrew S. Azman, Ebrahim Babaee, Alaa Badawi, Mojtaba Bagherzadeh, Shankar M. Bakkannavar, Senthilkumar Balakrishnan, Maciej Banach, Joseph Adel Mattar Banoub, Aleksandra Barac, Miguel A. Barboza, Till Winfried Barnighausen, Sanjay Basu, Vo Dinh Bay, Mohsen Bayati, Neeraj Bedi, Mahya Beheshti, Meysam Behzadifar, Masoud Behzadifar, Diana Fernanda Bejarano Ramirez, Michelle L. Bell, Derrick A. Bennett, Habib Benzian, Dessalegn Ajema Berbada, Robert S. Bernstein, Anusha Ganapati Bhat, Krittika Bhattacharyya, Soumyadeep Bhaumik, Zulfiqar A. Bhutta, Ali Bijani, Boris Bikbov, Muhammad Shahdaat Bin Sayeed, Raaj Kishore Biswas, Somayeh Bohlouli, Soufiane Boufous, Oliver J. Brady, Andrey Nikolaevich Briko, Nikolay Ivanovich Briko, Gabrielle B. Britton, Alexandria Brown, Sharath Burugina Nagaraja, Zahid A. Butt, Luis Alberto Camera, Ismael R. Campos-Nonato, Julio Cesar Campuzano Rincon, Jorge Cano, Josip Car, Rosario Cardenas, Felix Carvalho, Carlos A. Castaneda-Orjuela, Franz Castro, Ester Cerin, Binaya Chalise, Vijay Kumar Chattu, Ken Lee Chin, Devasahayam J. Christopher, Dinh-Toi Chu, Natalie Maria Cormier, Vera Marisa Costa, Elizabeth A. Cromwell, Abel Fekadu Fekadu Dadi, Tukur Dahiru, Saad M. A. Dahlawi, Rakhi Dandona, Lalit Dandona, Anh Kim Dang, Farah Daoud, Aso Mohammad Darwesh, Amira Hamed Darwish, Ahmad Daryani, Jai K. Das, Rajat Das Gupta, Aditya Prasad Dash, Claudio Alberto Davila-Cervantes, Nicole Davis Weaver, Fernando Pio De la Hoz, Jan-Walter De Neve, Dereje Bayissa Demissie, Gebre Teklemariam Demoz, Edgar Denova-Gutierrez, Kebede Deribe, Assefa Desalew, Samath Dhamminda Dharmaratne, Preeti Dhillon, Meghnath Dhimal, Govinda Prasad Dhungana, Daniel Diaz, Isaac Oluwafemi Dipeolu, Hoa Thi, Christiane Dolecek, Kerrie E. Doyle, Eleonora Dubljanin, Andre Rodrigues Duraes, Hisham Atan Edinur, Andem Effiong, Aziz Eftekhari, Nevine El Nahas, Maysaa El Sayed Zaki, Maha El Tantawi, Hala Rashad Elhabashy, Shaimaa El-Jaafary, Ziad El-Khatib, Hajer Elkout, Aisha Elsharkawy, Shymaa Enany, Daniel Adane Endalew, Babak Eshrati, Sharareh Eskandarieh, Arash Etemadi, Oluchi Ezekannagha, Emerito Jose A. Faraon, Mohammad Fareed, Andre Faro, Farshad Farzadfar, Alebachew Fasil Fasil, Mehdi Fazlzadeh, Valery L. Feigin, Wubalem Fekadu, Netsanet Fentahun, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Irina Filip, Florian Fischer, Carsten Flohr, Nataliya A. Foigt, Morenike Oluwatoyin Folayan, Masoud Foroutan, Richard Charles Franklin, Joseph Jon Frostad, Takeshi Fukumoto, Mohamed M. Gad, Gregory M. Garcia, Augustine Mwangi Gatotoh, Reta Tsegaye Gayesa, Ketema Bizuwork Gebremedhin, Yilma Chisha Dea Geramo, Hailay Abrha Gesesew, Kebede Embaye Gezae, Ahmad Ghashghaee, Farzaneh Ghazi Sherbaf, Tiffany K. Gill, Paramjit Singh Gill, Themba G. Ginindza, Alem Girmay, Zemichael Gizaw, Amador Goodridge, Sameer Vali Gopalani, Barbara Niegia Garcia Goulart, Alessandra C. Goulart, Ayman Grada, Manfred S. Green, Mohammed Ibrahim Mohialdeen Gubari, Harish Chander Gugnani, Davide Guido, Rafael Alves Guimaraes, Yuming Guo, Rajeev Gupta, Rahul Gupta, Giang Hai Ha, Juanita A. Haagsma, Nima Hafezi-Nejad, Dessalegn H. Haile, Michael Tamene Haile, Brian J. Hall, Samer Hamidi, Demelash Woldeyohannes Handiso, Hamidreza Haririan, Ninuk Hariyani, Ahmed Hasaballah, Mehedi Hasan, Amir Hasanzadeh, Hamid Yimam Hassen, Desta Haftu Hayelom, Mohamed Hegazy, Behzad Heibati, Behnam Heidari, Delia Hendrie, Andualem Henok, Claudiu Herteliu, Fatemeh Heydarpour, Hagos Degefa de Hidru, Thomas R. Hird, Chi Linh Hoang, Gillian Hollerich, Praveen Hoogar, Naznin Hossain, Mehdi Hosseinzadeh, Mowafa Househ, Guoqing Hu, Ayesha Humayun, Syed Ather Hussain, Mamusha Aman A. Hussen, Segun Emmanuel Ibitoye, Olayinka Stephen Ilesanmi, Milena D. Ilic, Mohammad Hasan Imani-Nasab, Usman Iqbal, Seyed Sina Naghibi Irvani, Sheikh Mohammed Shariful Islam, Rebecca Q. Ivers, Chinwe Juliana Iwu, Nader Jahanmehr, Mihajlo Jakovljevic, Amir Jalali, Achala Upendra Jayatilleke, Ensiyeh Jenabi, Ravi Prakash Jha, Vivekanand Jha, John S. Ji, Jost B. Jonas, Jacek Jerzy Jozwiak, Ali Kabir, Zubair Kabir, Tanuj Kanchan, Andre Karch, Surendra Karki, Amir Kasaeian, Gebremicheal Gebreslassie Kasahun, Habtamu Kebebe Kasaye, Gebrehiwot G. Kassa, Getachew Mullu Kassa, Gbenga A. Kayode, Mihiretu M. Kebede, Peter Njenga Keiyoro, Daniel Bekele Ketema, Yousef Saleh Khader, Morteza Abdullatif Khafaie, Nauman Khalid, Rovshan Khalilov, Ejaz Ahmad Khan, Junaid Khan, Nuruzzaman Khan, Khaled Khatab, Mona M. Khater, Amir M. Khater, Maryam Khayamzadeh, Mohammad Khazaei, Mohammad Hossein Khosravi, Jagdish Khubchandani, Ali Kiadaliri, Yun Jin Kim, Ruth W. Kimokoti, Sezer Kisa, Adnan Kisa, Sonali Kochhar, Tufa Kolola, Hamidreza Komaki, Soewarta Kosen, Parvaiz A. Koul, Ai Koyanagi, Kewal Krishan, Barthelemy Kuate Defo, Nuworza Kugbey, Pushpendra Kumar, G. Anil Kumar, Manasi Kumar, Dian Kusuma, Carlo La Vecchia, Ben Lacey, Aparna Lal, Dharmesh Kumar Lal, Hilton Lam, Faris Hasan Lami, Van Charles Lansingh, Savita Lasrado, Georgy Lebedev, Paul H. Lee, Kate E. LeGrand, Mostafa Leili, Tsegaye Lolaso Lenjebo, Cheru Tesema Leshargie, Aubrey J. Levine, Sonia Lewycka, Shanshan Li, Shai Linn, Shiwei Liu, Jaifred Christian F. Lopez, Platon D. Lopukhov, Muhammed Magdy Abd El Razek, D. R. Mahadeshwara Prasad, Phetole Walter Mahasha, Narayan B. Mahotra, Azeem Majeed, Reza Malekzadeh, Deborah Carvalho Malta, Abdullah A. Mamun, Navid Manafi, Mohammad Ali Mansournia, Chabila Christopher Mapoma, Gabriel Martinez, Santi Martini, Francisco Rogerlandio Martins-Melo, Manu Raj Mathur, Benjamin K. Mayala, Mohsen Mazidi, Colm McAlinden, Birhanu Geta Meharie, Man Mohan Mehndiratta, Entezar Mehrabi Nasab, Kala M. Mehta, Teferi Mekonnen, Tefera Chane Mekonnen, Gebrekiros Gebremichael Meles, Hagazi Gebre Meles, Peter T. N. Memiah, Ziad A. Memish, Walter Mendoza, Ritesh G. Menezes, Seid Tiku Mereta, Tuomo J. Meretoja, Tomislav Mestrovic, Workua Mekonnen Metekiya, Bartosz Miazgowski, Ted R. Miller, G. K. Mini, Erkin M. Mirrakhimov, Babak Moazen, Bahram Mohajer, Yousef Mohammad, Dara K. Mohammad, Naser Mohammad Gholi Mezerji, Roghayeh Mohammadibakhsh, Shafiu Mohammed, Jemal Abdu Mohammed, Hassen Mohammed, Farnam Mohebi, Ali H. Mokdad, Yoshan Moodley, Masoud Moradi, Ghobad Moradi, Mohammad Moradi-Joo, Paula Moraga, Linda Morales, Abbas Mosapour, Jonathan F. Mosser, Simin Mouodi, Seyyed Meysam Mousavi, Miliva Mozaffor, Sandra B. Munro, Moses K. Muriithi, Christopher J. L. Murray, Kamarul Imran Musa, Ghulam Mustafa, Saravanan Muthupandian, Mehdi Naderi, Ahamarshan Jayaraman Nagarajan, Mohsen Naghavi, Gurudatta Naik, Vinay Nangia, Bruno Ramos Nascimento, Javad Nazari, Duduzile Edith Ndwandwe, Ionut Negoi, Henok Biresaw Netsere, Josephine W. Ngunjiri, Cuong Tat Nguyen, Huong Lan Thi Nguyen, QuynhAnh P. Nguyen, Solomon Gedlu Nigatu, Dina Nur Anggraini Ningrum, Chukwudi A. Nnaji, Marzieh Nojomi, Ole F. Norheim, Jean Jacques Noubiap, Bogdan Oancea, Felix Akpojene Ogbo, In-Hwan Oh, Andrew T. Olagunju, Jacob Olusegun Olusanya, Bolajoko Olubukunola Olusanya, Obinna E. Onwujekwe, Doris Ortega-Altamirano, Osayomwanbo Osarenotor, Frank B. Osei, Mayowa O. Owolabi, P. A. Mahesh, Jagadish Rao Padubidri, Smita Pakhale, Adrian Pana, Eun-Kee Park, Sangram Kishor Patel, Ashish Pathak, Ajay Patle, Kebreab Paulos, Veincent Christian Filipino Pepito, Norberto Perico, Aslam Pervaiz, Julia Moreira Pescarini, Konrad Pesudovs, Hai Quang Pham, David M. Pigott, Thomas Pilgrim, Meghdad Pirsaheb, Mario Poljak, Ian Pollock, Maarten J. Postma, Farshad Pourmalek, Akram Pourshams, Sergio Prada, Liliana Preotescu, Hedley Quintana, Navid Rabiee, Mohammad Rabiee, Amir Radfar, Alireza Rafiei, Fakher Rahim, Siavash Rahimi, Vafa Rahimi-Movaghar, Muhammad Aziz Rahman, Mohammad Hifz Ur Rahman, Fatemeh Rajati, Chhabi Lal Ranabhat, Puja C. Rao, Davide Rasella, Goura Kishor Rath, Salman Rawaf, Lal Rawal, Wasiq Faraz Rawasia, Giuseppe Remuzzi, Vishnu Renjith, Andre M. N. Renzaho, Serge Resnikoff, Seyed Mohammad Riahi, Ana Isabel Ribeiro, Jennifer Rickard, Leonardo Roever, Luca Ronfani, Enrico Rubagotti, Salvatore Rubino, Anas M. Saad, Siamak Sabour, Ehsan Sadeghi, Sahar Saeedi Moghaddam, Yahya Safari, Rajesh Sagar, Mohammad Ali Sahraian, S. Mohammad Sajadi, Mohammad Reza Salahshoor, Nasir Salam, Ahsan Saleem, Hosni Salem, Marwa Rashad Salem, Yahya Salimi, Hamideh Salimzadeh, Abdallah M. Samy, Juan Sanabria, Itamar S. Santos, Milena M. Santric-Milicevic, Bruno Piassi Sao Jose, Sivan Yegnanarayana Iyer Saraswathy, Nizal Sarrafzadegan, Benn Sartorius, Brijesh Sathian, Thirunavukkarasu Sathish, Maheswar Satpathy, Monika Sawhney, Mehdi Sayyah, Alyssa N. Sbarra, Lauren E. Schaeffer, David C. Schwebel, Anbissa Muleta Senbeta, Subramanian Senthilkumaran, Sadaf G. Sepanlou, Edson Servan-Mori, Azadeh Shafieesabet, Amira A. Shaheen, Izza Shahid, Masood Ali Shaikh, Ali S. Shalash, Mehran Shams-Beyranvand, MohammadBagher Shamsi, Morteza Shamsizadeh, Mohammed Shannawaz, Kiomars Sharafi, Rajesh Sharma, Aziz Sheikh, B. Suresh Kumar Shetty, Wondimeneh Shibabaw Shiferaw, Mika Shigematsu, Jae Il Shin, Rahman Shiri, Reza Shirkoohi, K. M. Shivakumar, Si Si, Soraya Siabani, Tariq Jamal Siddiqi, Diego Augusto Santos Silva, Virendra Singh, Narinder Pal Singh, Balbir Bagicha Singh Singh, Jasvinder A. Singh, Ambrish Singh, Dhirendra Narain Sinha, Malede Mequanent Sisay, Eirini Skiadaresi, David L. Smith, Adauto Martins Soares Filho, Mohammad Reza Sobhiyeh, Anton Sokhan, Joan B. Soriano, Muluken Bekele Sorrie, Ireneous N. Soyiri, Emma Elizabeth Spurlock, Chandrashekhar T. Sreeramareddy, Agus Sudaryanto, Mu'awiyyah Babale Sufiyan, Hafiz Ansar Rasul Suleria, Bryan L. Sykes, Rafael Tabares-Seisdedos, Takahiro Tabuchi, Degena Bahrey Tadesse, Ingan Ukur Tarigan, Bineyam Taye, Yonatal Mesfin Tefera, Arash Tehrani-Banihashemi, Shishay Wahdey Tekelemedhin, Merhawi Gebremedhin Tekle, Mohamad-Hani Temsah, Berhe Etsay Tesfay, Fisaha Haile Tesfay, Zemenu Tadesse Tessema, Kavumpurathu Raman Thankappan, Akhil Soman ThekkePurakkal, Nihal Thomas, Robert L. Thompson, Alan J. Thomson, Roman Topor-Madry, Marcos Roberto Tovani-Palone, Eugenio Traini, Bach Xuan Tran, Khanh Bao Tran, Irfan Ullah, Bhaskaran Unnikrishnan, Muhammad Shariq Usman, Olalekan A. Uthman, Benjamin S. Chudi Uzochukwu, Pascual R. Valdez, Santosh Varughese, Yousef Veisani, Francesco S. Violante, Sebastian Vollmer, Feleke Gebremeskel Whawariat, Yasir Waheed, Mitchell Taylor Wallin, Yuan-Pang Wang, Yafeng Wang, Kinley Wangdi, Daniel J. Weiss, Girmay Teklay Weldesamuel, Adhena Ayaliew Werkneh, Ronny Westerman, Taweewat Wiangkham, Kirsten E. Wiens, Tissa Wijeratne, Charles Shey Wiysonge, Haileab Fekadu Wolde, Dawit Zewdu Wondafrash, Tewodros Eshete Wonde, Getasew Taddesse Worku, Ali Yadollahpour, Seyed Hossein Yahyazadeh Jabbari, Tomohide Yamada, Mehdi Yaseri, Hiroshi Yatsuya, Alex Yeshaneh, Mekdes Tigistu Yilma, Paul Yip, Engida Yisma, Naohiro Yonemoto, Mustafa Z. Younis, Hebat-Allah Salah A. Yousof, Chuanhua Yu, Hasan Yusefzadeh, Siddhesh Zadey, Telma Zahirian Moghadam, Zoubida Zaidi, Sojib Bin Zaman, Mohammad Zamani, Hamed Zandian, Heather J. Zar, Taddese Alemu Zerfu, Yunquan Zhang, Arash Ziapour, Sanjay Zodpey, Yves Miel H. Zuniga, Simon Hay, Robert C. Reiner

LANCET GLOBAL HEALTH 8 巻 ( 9 ) 頁： E1162 - E1185 2020年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCI LTD

Background Universal access to safe drinking water and sanitation facilities is an essential human right, recognised in the Sustainable Development Goals as crucial for preventing disease and improving human wellbeing. Comprehensive, high-resolution estimates are important to inform progress towards achieving this goal. We aimed to produce high-resolution geospatial estimates of access to drinking water and sanitation facilities.Methods We used a Bayesian geostatistical model and data from 600 sources across more than 88 low-income and middle-income countries (LMICs) to estimate access to drinking water and sanitation facilities on continuous continent-wide surfaces from 2000 to 2017, and aggregated results to policy-relevant administrative units. We estimated mutually exclusive and collectively exhaustive subcategories of facilities for drinking water (piped water on or off premises, other improved facilities, unimproved, and surface water) and sanitation facilities (septic or sewer sanitation, other improved, unimproved, and open defecation) with use of ordinal regression. We also estimated the number of diarrhoeal deaths in children younger than 5 years attributed to unsafe facilities and estimated deaths that were averted by increased access to safe facilities in 2017, and analysed geographical inequality in access within LMICs.Findings Across LMICs, access to both piped water and improved water overall increased between 2000 and 2017, with progress varying spatially. For piped water, the safest water facility type, access increased from 40.0% (95% uncertainty interval [UI] 39.4-40.7) to 50.3% (50.0-50.5), but was lowest in sub-Saharan Africa, where access to piped water was mostly concentrated in urban centres. Access to both sewer or septic sanitation and improved sanitation overall also increased across all LMICs during the study period. For sewer or septic sanitation, access was 46.3% (95% UI 46.1-46.5) in 2017, compared with 28.7% (28.5-29.0) in 2000. Although some units improved access to the safest drinking water or sanitation facilities since 2000, a large absolute number of people continued to not have access in several units with high access to such facilities (>80%) in 2017. More than 253 000 people did not have access to sewer or septic sanitation facilities in the city of Harare, Zimbabwe, despite 88.6% (95% UI 87.2-89.7) access overall. Many units were able to transition from the least safe facilities in 2000 to safe facilities by 2017; for units in which populations primarily practised open defecation in 2000, 686 (95% UI 664-711) of the 1830 (1797-1863) units transitioned to the use of improved sanitation. Geographical disparities in access to improved water across units decreased in 76.1% (95% UI 71.6-80.7) of countries from 2000 to 2017, and in 53.9% (50.6-59.6) of countries for access to improved sanitation, but remained evident subnationally in most countries in 2017.Interpretation Our estimates, combined with geospatial trends in diarrhoeal burden, identify where efforts to increase access to safe drinking water and sanitation facilities are most needed. By highlighting areas with successful approaches or in need of targeted interventions, our estimates can enable precision public health to effectively progress towards universal access to safe water and sanitation. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd.

DOI： 10.1016/S2214-109X(20)30278-3

降圧薬ヒドララジンは高脂肪食摂取した高血圧ラットの肝線維化を抑制する

The Smart Life Stay (SLS) program: effects of a lifestyle intervention program in combination with health tourism and health guidance for type 2 diabetes 査読有り国際誌 Open Access

Matsushita, M; Muramoto, A; Nomura, E; Eguchi, Y; Kato, A; Sano, Y; Kabayama, M; Arakawa, M; Oguma, Y; Yabe, D; Matsunaga, M; Yatsuya, H; Arima, H; Tsushita, K

NUTRITION & DIABETES 10 巻 ( 1 ) 頁： 33 - 33 2020年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nutrition and Diabetes

Background: The aim of this study was to determine the effectiveness of the Smart Life Stay (SLS) program, which is an experience-oriented stayover program, in combination with health tourism and mandatory health guidance on glucose metabolism after 2 years. Methods: The participants of the SLS program (n = 792) were recruited from a database of 23 medical insurers. They underwent a mandatory health examination termed Specific Health Checkups in 2014. The participants were included if they had diabetes or were at a high risk of diabetes and if they satisfied the following inclusion criteria: (1) body mass index (BMI; kg/m2) > 25, or (2) waist circumference (WC; cm) > 85 for men and > 90 for women, or (3) hemoglobin A1c (HbA1c; %) > 5.6, or (4) fasting plasma glucose (FPG; mg/dl) > 100. Individuals who corresponded to one or more items were included as study participants. The control subjects (n = 3645) were nonparticipants of the program who were selected from the database and met the inclusion criteria. The lifestyle changes and changes in mean BMI, WC, FPG, and HbA1c in both groups from baseline to 2-year follow-up were compared by inverse probability weighting of a propensity score. Results: The percentage of people who exercised regularly increased significantly in the SLS group compared with the control group. In the SLS group, BW, BMI, and WC significantly decreased by 1.75 kg, 0.60 kg/m2, and 1.45 cm, respectively, whereas in the control group, WC, FPG, and HbA1c increased significantly by 0.38 cm, 3.37 mg/dl, and 0.12%, respectively. The comparison between groups revealed that the BW, BMI, WC, FPG, and HbA1c improved significantly in the SLS group. Conclusions: The SLS program is suggested to help improve glucose metabolism. This program could be a feasible option as a lifestyle intervention program for diabetes.

DOI： 10.1038/s41387-020-00136-x

Risk Factors of Infectious Complications After Endobronchial Ultrasound-Guided Transbronchial Biopsy 査読有り国際誌 Open Access

Souma, T; Minezawa, T; Yatsuya, H; Okamura, T; Yamatsuta, K; Morikawa, S; Horiguchi, T; Maeda, S; Goto, Y; Hayashi, M; Isogai, S; Yamamoto, N; Kondo, M; Imaizumi, K

CHEST 158 巻 ( 2 ) 頁： 797 - 807 2020年8月

Glycated haemoglobin (HbA1c) as a reliable option for detecting diabetes among the urban poor population in Bangladesh 査読有り国際共著国際誌 Open Access

Chiang, CF; Aoyama, A; Khalequzzaman, M; Choudhury, SR; Paul, D; Rayna, SE; Khan, FA; Hirakawa, Y; Iso, H; Yatsuya, H

EUROPEAN JOURNAL OF PUBLIC HEALTH 30 巻 ( 4 ) 頁： 839 - 841 2020年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：European Journal of Public Health

Our previous epidemiological survey targeting urban slum dwellers in Bangladesh showed that the prevalence of diabetes defined by glycated haemoglobin (HbA1c) was higher than the national estimation, and higher in women than men. Subsequently, we conducted the oral glucose tolerance test (OGTT) and found that HbA1c values were consistent with the OGTT findings for detecting diabetes. Our findings indicated that HbA1c ≥6.5% was a rational cut-off, but the optimal HbA1c cut-off for this population might be lower than the internationally recommended threshold. Measuring HbA1c would be a reliable and feasible option for detecting diabetes among underprivileged population in developing countries.

DOI： 10.1093/eurpub/cky275

Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000-17 査読有り国際共著国際誌

Wiens Kirsten E., Lindstedt Paulina A., Blacker Brigette F., Johnson Kimberly B., Baumann Mathew M., Schaeffer Lauren E., Abbastabar Hedayat, Abd-Allah Foad, Abdelalim Ahmed, Abdollahpour Ibrahim, Abegaz Kedir Hussein, Abejie Ayenew Negesse, Abreu Lucas Guimaraes, Abrigo Michael R. M., Abualhasan Ahmed, Accrombessi Manfred Mario Kokou, Acharya Dilaram, Adabi Maryam, Adamu Abdu A., Adebayo Oladimeji M., Adedoyin Rufus Adesoji, Adekanmbi Victor, Adetokunboh Olatunji O., Adhena Beyene Meressa, Afarideh Mohsen, Ahmad Sohail, Ahmadi Keivan, Ahmed Anwar E., Ahmed Muktar Beshir, Ahmed Rushdia, Akalu Temesgen Yihunie, Alahdab Fares, Al-Aly Ziyad, Alam Noore, Alam Samiah, Alamene Genet Melak, Alanzi Turki M., Alcalde-Rabanal Jacqueline Elizabeth, Ali Beriwan Abdulqadir, Alijanzadeh Mehran, Alipour Vahid, Aljunid Syed Mohamed, Almasi Ali, Almasi-Hashiani Amir, Al-Mekhlafi Hesham M., Altirkawi Khalid A., Alvis-Guzman Nelson, Alvis-Zakzuk Nelson J., Amini Saeed, Amit Arianna Maever L., Andrei Catalina Liliana, Anjomshoa Mina, Anoushiravani Amir, Ansari Fereshteh, Antonio Carl Abelardo T., Antony Benny, Antriyandarti Ernoiz, Arabloo Jalal, Aref Hany Mohamed Amin, Aremu Olatunde, Armoon Bahram, Arora Amit, Aryal Krishna K., Arzani Afsaneh, Asadi-Aliabadi Mehran, Atalay Hagos Tasew, Athari Seyyed Shamsadin, Athari Seyyede Masoume, Atre Sachin R., Ausloos Marcel, Awoke Nefsu, Quintanilla Beatriz Paulina Ayala, Ayano Getinet, Ayanore Martin Amogre, Aynalem Yared Asmare, Azari Samad, Azzopardi Peter S., Babaee Ebrahim, Babalola Tesleem Kayode, Badawi Alaa, Bairwa Mohan, Bakkannavar Shankar M., Balakrishnan Senthilkumar, Bali Ayele Geleto, Banach Maciej, Banoub Joseph Adel Mattar, Barac Aleksandra, Barnighausen Till Winfried, Basaleem Huda, Basu Sanjay, Bay Vo Dinh, Bayati Mohsen, Baye Estifanos, Bedi Neeraj, Beheshti Mahya, Behzadifar Masoud, Behzadifar Meysam, Bekele Bayu Begashaw, Belayneh Yaschilal Muche, Bell Michelle L., Bennett Derrick A., Berbada Dessalegn Ajema, Bernstein Robert S., Bhat Anusha Ganapati, Bhattacharyya Krittika, Bhattarai Suraj, Bhaumik Soumyadeep, Bhutta Zulfiqar A., Bijani Ali, Bikbov Boris, Birihane Binyam Minuye, Biswas Raaj Kishore, Bohlouli Somayeh, Bojia Hunduma Amensisa, Boufous Soufiane, Brady Oliver J., Bragazzi Nicola Luigi, Briko Andrey Nikolaevich, Briko Nikolay Ivanovich, Britton Gabrielle B., Nagaraja Sharath Burugina, Busse Reinhard, Butt Zahid A., Camera Luis Alberto, Campos-Nonato Ismael R., Cano Jorge, Car Josip, Cardenas Rosario, Carvalho Felix, Castaneda-Orjuela Carlos A., Castro Franz, Chanie Wagaye Fentahun, Chatterjee Pranab, Chattu Vijay Kumar, Chichiabellu Tesfaye Yitna, Chin Ken Lee, Christopher Devasahayam J., Chu Dinh-Toi, Cormier Natalie Maria, Costa Vera Marisa, Culquichicon Carlos, Daba Matiwos Soboka, Damiani Giovanni, Dandona Lalit, Dandona Rakhi, Dang Anh Kim, Darwesh Aso Mohammad, Darwish Amira Hamed, Daryani Ahmad, Das Jai K., Das Gupta Rajat, Dash Aditya Prasad, Davey Gail, Davila-Cervantes Claudio Alberto, Davis Adrian C., Davitoiu Dragos Virgil, De la Hoz Fernando Pio, Demis Asmamaw Bizuneh, Demissie Dereje Bayissa, Demissie Getu Debalkie, Demoz Gebre Teklemariam, Demoz Gebre Teklemariam, Denova-Gutierrez Edgar, Deribe Kebede, Desalew Assefa, Deshpande Aniruddha, Dharmaratne Samath Dhamminda, Dhillon Preeti, Dhimal Meghnath, Dhungana Govinda Prasad, Diaz Daniel, Dipeolu Isaac Oluwafemi, Djalalinia Shirin, Doyle Kerrie E., Dubljanin Eleonora, Duko Bereket, Duraes Andre Rodrigues, Kalan Mohammad Ebrahimi, Edinur Hisham Atan, Effiong Andem, Eftekhari Aziz, El Nahas Nevine, El Sayed Iman, Zaki Maysaa El Sayed, El Tantawi Maha, Elema Teshome Bekele, Elhabashy Hala Rashad, El-Jaafary Shaimaa I., Elkout Hajer, Elsharkawy Aisha, Elyazar Iqbal R. F., Endalamaw Aklilu, Endalew Daniel Adane, Eskandarieh Sharareh, Esteghamati Alireza, Esteghamati Sadaf, Etemadi Arash, Ezekannagha Oluchi, Fareed Mohammad, Faridnia Roghiyeh, Farzadfar Farshad, Fazlzadeh Mehdi, Feigin Valery L., Fereshtehnejad Seyed-Mohammad, Fernandes Eduarda, Filip Irina, Fischer Florian, Foigt Nataliya A., Folayan Morenike Oluwatoyin, Foroutan Masoud, Franklin Richard Charles, Fukumoto Takeshi, Gad Mohamed M., Gayesa Reta Tsegaye, Gebre Teshome, Gebremedhin Ketema Bizuwork, Gebremeskel Gebreamlak Gebremedhn, Gesesew Hailay Abrha, Gezae Kebede Embaye, Ghadiri Keyghobad, Ghashghaee Ahmad, Ghimire Pramesh Raj, Gill Paramjit Singh, Gill Tiffany K., Ginindza Themba G., Gomes Nelson G. M., Gopalani Sameer Vali, Goulart Alessandra C., Goulart Barbara Niegia Garcia, Grada Ayman, Gubari Mohammed Ibrahim Mohialdeen, Gugnani Harish Chander, Guido Davide, Guimaraes Rafael Alves, Guo Yuming, Gupta Rajeev, Hafezi-Nejad Nima, Haile Dessalegn H., Hailu Gessessew Bugssa, Haj-Mirzaian Arvin, Haj-Mirzaian Arya, Hamadeh Randah R., Hamidi Samer, Handiso Demelash Woldeyohannes, Haririan Hamidreza, Hariyani Ninuk, Hasaballah Ahmed I., Hasan Md Mehedi, Hasanpoor Edris, Hasanzadeh Amir, Hassankhani Hadi, Hassen Hamid Yimam, Hegazy Mohamed I., Heibati Behzad, Heidari Behnam, Hendrie Delia, Henry Nathaniel J., Herteliu Claudiu, Heydarpour Fatemeh, de Hidru Hagos Degefa, Hird Thomas R., Hoang Chi Linh, Rad Enayatollah Homaie, Hoogar Praveen, Hoseini Mohammad, Hossain Naznin, Hosseini Mostafa, Hosseinzadeh Mehdi, Househ Mowafa, Hsairi Mohamed, Hu Guoqing, Hussen Mohammedaman Mama, Ibitoye Segun Emmanuel, Igumbor Ehimario U., Ilesanmi Olayinka Stephen, Ilic Milena D., Imani-Nasab Mohammad Hasan, Iqbal Usman, Irvani Seyed Sina Naghibi, Islam Sheikh Mohammed Shariful, Iwu Chinwe Juliana, Izadi Neda, Jaca Anelisa, Jahanmehr Nader, Jakovljevic Mihajlo, Jalali Amir, Jayatilleke Achala Upendra, Jha Ravi Prakash, Jha Vivekanand, Ji John S., Jonas Jost B., Jozwiak Jacek Jerzy, Kabir Ali, Kabir Zubair, Kahsay Amaha, Kalani Hamed, Kanchan Tanuj, Matin Behzad Karami, Karch Andre, Karim Mohd Anisul, Karki Hamidreza Karimi-Sari Surendra, Kasaeian Amir, Kasahun Gebremicheal Gebreslassie, Kasahun Yawukal Chane, Kasaye Habtamu Kebebe, Kassa Gebrehiwot G., Kassa Getachew Mullu, Kayode Gbenga A., Karyani Ali Kazemi, Kebede Mihiretu M., Keiyoro Peter Njenga, Kelbore Abraham Getachew, Kengne Andre Pascal, Ketema Daniel Bekele, Khader Yousef Saleh, Khafaie Morteza Abdullatif, Khalid Nauman, Khalilov Rovshan, Khan Ejaz Ahmad, Khan Junaid, Khan Md Nuruzzaman, Khan Muhammad Shahzeb, Khatab Khaled, Khater Amir M., Khater Mona M., Khayamzadeh Maryam, Khazaei Mohammad, Khazaei Salman, Khosravi Mohammad Hossein, Khubchandani Jagdish, Kiadaliri Ali, Kim Yun Jin, Kimokoti Ruth W., Kisa Adnan, Kisa Sezer, Kissoon Niranjan, Shivakumar K. M., Kochhar Sonali, Kolola Tufa, Komaki Hamidreza, Kosen Soewarta, Koul Parvaiz A., Koyanagi Ai, Kraemer Moritz U. G., Krishan Kewal, Kugbey Nuworza, Kumar G. Anil, Kumar Manasi, Kumar Pushpendra, Kusuma Vivek Kumar Dian, La Vecchia Carlo, Lacey Ben, Lad Sheetal D., Lal Dharmesh Kumar, Lam Felix, Lami Faris Hasan, Lamichhane Prabhat, Lansingh Van Charles, Lasrado Savita, Laxmaiah Avula, Lee Paul H., LeGrand Kate E., Leili Mostafa, Lenjebo Tsegaye Lolaso, Leshargie Cheru Tesema, Levine Aubrey J., Li Shanshan, Linn Shai, Liu Shiwei, Liu Simin, Lodha Rakesh, Longbottom Joshua, Lopez Jaifred Christian F., Abd El Razek Hassan Magdy, Abd El Razek Muhammed Magdy, Prasad D. R. Mahadeshwara, Mahasha Phetole Walter, Mahotra Narayan B., Majeed Azeem, Malekzadeh Reza, Malta Deborah Carvalho, Mamun Abdullah A., Manafi Navid, Manda Ana Laura, Manohar Narendar Dawani Dawanu, Mansournia Mohammad Ali, Mapoma Chabila Christopher, Maravilla Joemer C., Martinez Gabriel, Martini Santi, Martins-Melo Francisco Rogerlandio, Masaka Anthony, Massenburg Benjamin Ballard, Mathur Manu Raj, Mayala Benjamin K., Mazidi Mohsen, McAlinden Colm, Meharie Birhanu Geta, Mehndiratta Man Mohan, Mehta Kala M., Mekonnen Tefera Chane, Meles Gebrekiros Gebremichael, Memiah Peter T. N., Memish Ziad A., Mendoza Walter, Menezes Ritesh G., Mereta Seid Tiku, Meretoja Tuomo J., Mestrovic Tomislav, Miazgowski Bartosz, Mihretie Kebadnew Mulatu, Miller Ted R., Mini G. K., Mirrakhimov Erkin M., Moazen Babak, Mohajer Bahram, Mohamadi-Bolbanabad Amjad, Mohammad Dara K., Mohammad Karzan Abdulmuhsin, Mohammad Yousef, Mezerji Naser Mohammad Gholi, Mohammadibakhsh Roghayeh, Mohammadifard Noushin, Mohammed Jemal Abdu, Mohammed Shafiu, Mohebi Farnam, Mokdad Ali H., Molokhia Mariam, Monasta Lorenzo, Moodley Yoshan, Moore Catrin E., Moradi Ghobad, Moradi Masoud, Moradi-Joo Mohammad, Moradi-Lakeh Maziar, Moraga Paula, Morales Linda, Velasquez Ilais Moreno, Mosapour Abbas, Mouodi Simin, Mousavi Seyyed Meysam, Mozaffor Miliva, Muchie Kindie Fentahun, Mulaw Getahun Fentaw, Munro Sandra B., Muriithi Moses K., Murray Christoper J. L., Murthy G. V. S., Musa Kamarul Imran, Mustafa Ghulam, Muthupandian Saravanan, Nabhan Ashraf F., Naderi Mehdi, Nagarajan Ahamarshan Jayaraman, Naidoo Kovin S., Naik Gurudatta, Najafi Farid, Nangia Vinay, Nansseu Jobert Richie, Nascimento Bruno Ramos, Nazari Javad, Ndwandwe Duduzile Edith, Negoi Ionut, Netsere Henok Biresaw, Ngunjiri Josephine W., Nguyen Cuong Tat, Nguyen Huong Lan Thi, Nguyen Trang Huyen, Nigatu Dabere, Nigatu Solomon Gedlu, Ningrum Dina Nur Anggraini, Nnaji Chukwudi A., Nojomi Marzieh, Nong Vuong Minh, Norheim Ole F., Noubiap Jean Jacques, Motlagh Soraya Nouraei, Oancea Bogdan, Ogah Okechukwu Samuel, Ogbo Felix Akpojene, Oh In-Hwan, Olagunju Andrew T., Olagunju Tinuke O., Olusanya Bolajoko Olubukunola, Olusanya Jacob Olusegun, Onwujekwe Obinna E., Oren Eyal, Ortega-Altamirano Doris V., Osarenotor Osayomwanbo, Osei Frank B., Owolabi Mayowa O., Mahesh P. A., Padubidri Jagadish Rao, Pakhale Smita, Patel Sangram Kishor, Paternina-Caicedo Angel J., Pathak Ashish, Patton George C., Paudel Deepak, Paulos Kebreab, Pepito Veincent Christian Filipino, Pereira Alexandre, Perico Norberto, Pervaiz Aslam, Pescarini Julia Moreira, Piroozi Bakhtiar, Pirsaheb Meghdad, Postma Maarten J., Pourjafar Hadi, Pourmalek Farshad, Pourshams Akram, Poustchi Hossein, Prada Sergio I., Prasad Narayan, Preotescu Liliana, Quintana Hedley, Rabiee Navid, Radfar Amir, Rafiei Alireza, Rahim Fakher, Rahimi-Movaghar Afarin, Rahimi-Movaghar Vafa, Rahman Mohammad Hifz Ur, Rahman Muhammad Aziz, Rahman Shafiur, Rajati Fatemeh, Rana Saleem Muhammad, Ranabhat Chhabi Lal, Rasella Davide, Rawaf David Laith, Rawaf Salman, Rawal Lal, Rawasia Wasiq Faraz, Renjith Vishnu, Renzaho Andre M. N., Resnikoff Serge, Reta Melese Abate, Rezaei Negar, Rezai Mohammad Sadegh, Riahi Seyed Mohammad, Ribeiro Ana Isabel, Rickard Jennifer, Rios-Blancas Maria, Roever Leonardo, Ronfani Luca, Roro Elias Merdassa, Ross Jennifer M., Rubagotti Enrico, Rubino Salvatore, Saad Anas M., Sabde Yogesh Damodar, Sabour Siamak, Sadeghi Ehsan, Safari Yahya, Safari-Faramani Roya, Sagar Rajesh, Sahebkar Amirhossein, Sahraian Mohammad Ali, Sajadi S. Mohammad, Salahshoor Mohammad Reza, Salam Nasir, Salamati Payman, Salem Hosni, Salem Marwa Rashad, Salimi Yahya, Salimzadeh Hamideh, Samy Abdallah M., Sanabria Juan, Santric-Milicevic Milena M., Jose Bruno Piassi Sao, Saraswathy Sivan Yegnanarayana Iyer, Sarkar Kaushik, Sarker Abdur Razzaque, Sarrafzadegan Nizal, Sartorius Benn, Sathian Brijesh, Sathish Thirunavukkarasu, Sawhney Monika, Saxena Sonia, Schwebel David C., Senbeta Anbissa Muleta, Senthilkumaran Subramanian, Sepanlou Sadaf G., Servan-Mori Edson, Shabaninejad Hosein, Shafieesabet Azadeh, Shaikh Masood Ali, Shalash Ali S., Shallo Seifadin Ahmed, Shams-Beyranvand Mehran, Shamsi MohammadBagher, Shamsizadeh Morteza, Shannawaz Mohammed, Sharafi Kiomars, Sharifi Hamid, Shehata Hatem Samir, Sheikh Aziz, Shetty B. Suresh Kumar, Shibuya Kenji, Shiferaw Wondimeneh Shibabaw, Shifti Desalegn Markos, Shigematsu Mika, Il Shin Jae, Shiri Rahman, Shirkoohi Reza, Siabani Soraya, Siddiqi Tariq Jamal, Silva Diego Augusto Santos, Singh Ambrish, Singh Jasvinder A., Singh Narinder Pal, Singh Virendra, Sisay Malede Mequanent, Skiadaresi Eirini, Sobhiyeh Mohammad Reza, Sokhan Anton, Soltani Shahin, Somayaji Ranjani, Soofi Moslem, Sorrie Muluken Bekele, Soyiri Ireneous N., Sreeramareddy Chandrashekhar T., Sudaryanto Agus, Sufiyan Mu'awiyyah Babale, Suleria Hafiz Ansar Rasul, Sultana Marufa, Sunguya Bruno Fokas, Sykes Bryan L., Tabares-Seisdedos Rafael, Tabuchi Takahiro, Tadesse Degena Bahrey, Tarigan Ingan Ukur, Tasew Aberash Abay, Tefera Yonatal Mesfin, Tekle Merhawi Gebremedhin, Temsah Mohamad-Hani, Tesfay Berhe Etsay, Tesfay Fisaha Haile, Tessema Belay, Tessema Zemenu Tadesse, Thankappan Kavumpurathu Raman, Thomas Nihal, Toma Alemayehu, Topor-Madry Roman, Tovani-Palone Marcos Roberto, Traini Eugenio, Tran Bach Xuan, Tran Khanh Bao, Ullah Irfan, Unnikrishnan Bhaskaran, Usman Muhammad Shariq, Uzochukwu Benjamin S. Chudi, Valdez Pascual R., Varughese Santosh, Violante Francesco S., Vollmer Sebastian, Hawariat Feleke Gebremeskel W., Waheed Yasir, Wallin Mitchell Taylor, Wang Yafeng, Wang Yuan-Pang, Weaver Marcia, Weji Bedilu Girma, Weldesamuel Girmay Teklay, Welgan Catherine A., Werdecker Andrea, Westerman Ronny, Wiangkham Taweewat, Wiysonge Charles Shey, Wolde Haileab Fekadu, Wondafrash Dawit Zewdu, Wonde Tewodros Eshete, Worku Getasew Taddesse, Wu Ai-Min, Xu Gelin, Yadollahpour Ali, Jabbari Seyed Hossein Yahyazadeh, Yamada Tomohide, Yatsuya Hiroshi, Yeshaneh Alex, Yilgwan Christopher Sabo, Yilma Mekdes Tigistu, Yip Paul, Yisma Engida, Yonemoto Naohiro, Yoon Seok-Jun, Younis Mustafa Z., Yousefifard Mahmoud, Yousof Hebat-Allah Salah A., Yu Chuanhua, Yusefzadeh Hasan, Zadey Siddhesh, Zaidi Zoubida, Bin Zaman Sojib, Zamani Mohammad, Zandian Hamed, Zepro Nejimu Biza, Zerfu Taddese Alemu, Zhang Yunquan, Zhao Xiu-Ju George, Ziapour Arash, Zodpey Sanjay, Zuniga Yves Miel H., Hay Simon I., Reiner Robert C. Jr.

LANCET GLOBAL HEALTH 8 巻 ( 8 ) 頁： 1038 - 1060 2020年8月

安全衛生担当労働者における加熱式タバコの利用状況査読有り

厚生の指標 67 巻 ( 6 ) 頁： 23 - 28 2020年6月

担当区分：最終著者記述言語：日本語掲載種別：研究論文（学術雑誌）

目的職域では受動喫煙対策とともに喫煙労働者への禁煙指導が課題となっている。日本の職域における加熱式タバコの使用実態を報告した論文は少ない。本研究の目的は,職域における加熱式タバコの使用実態を把握し,喫煙対策の実施につながる知見を得ることである。方法某労働災害防止団体の地方センターにおいて2019年4月〜6月末の3ヵ月間に開催した安全衛生教育受講者(819人)を対象にした自記式質問紙調査を実施した。喫煙率,加熱式タバコ利用状況,年齢,性別,役職,企業規模,喫煙習慣との関連を調べた。回答者741人のうち,男性回答者で分析に必要な項目に欠損がなかった653人を解析した。結果喫煙率は37.8%(247人)であった。現喫煙者割合は40〜49歳で高く(40.1%),過去喫煙者割合は50歳以上で高く(37.8%),非喫煙者割合は40歳未満で高かった(49.1%)(p<0.001)。役職,企業規模と現喫煙,過去喫煙,非喫煙の割合に有意な関連は認めなかった。現喫煙者247人の内,加熱式タバコのみを利用する者が67人(現喫煙者の27.1%),加熱式タバコと通常のタバコとの併用者が55人(現喫煙者の22.3%)であった。加熱式タバコの利用状況(加熱式のみ,併用,通常のタバコのみ)と年齢,役職,企業規模との間に統計学的に有意な関連は認めなかった。加熱式タバコの利用理由は「においが少ない」(67.2%),「煙が少ない」(47.5%),「火の心配が少ない」(43.4%),「自分の健康被害が少ないと思う」(35.2%),「周囲の健康被害が少ないと思う」(34.4%)であった。結論男性労働者の喫煙率には年齢による差はあったが,企業規模や役職による差はなかった。男性労働者の加熱式タバコの利用は20%程度で,全喫煙者の約半分であった。本研究では,健康被害よりもにおいや火に関連した危険を理由として加熱式タバコを利用する者が多かった。事業場においては,通常のタバコへの喫煙対策と併せて加熱式タバコへの対策も行うことが望まれる

Habitual tub bathing and risks of incident coronary heart disease and stroke 査読有り国際誌

Ukai, T; Iso, H; Yamagishi, K; Saito, I; Kokubo, Y; Yatsuya, H; Muraki, I; Eshak, ES; Sawada, N; Tsugane, S

HEART 106 巻 ( 10 ) 頁： 732 - 737 2020年5月

ウルソデオキシコール酸添加による高脂肪食誘導性肝炎・線維化の軽減作用

内藤久雄, 北森一哉, 橋本沙幸, 浅野友美, 八谷寛, 那須民江

産業衛生学雑誌 62 巻 ( 臨増 ) 頁： 610 - 610 2020年5月

内藤久雄, 袁媛, 北森一哉, 橋本沙幸, 浅野友美, 八谷寛, 那須民江

日本衛生学雑誌 75 巻 ( Suppl. ) 頁： S161 - S161 2020年3月

トリクロロエチレン曝露によるCYP2E1抗体の上昇とその影響因子

那須民江, 王海蘭, 袁媛, 内藤久雄, 伊藤由起, 柳場由絵, 八谷寛, 上島通浩

産業衛生学雑誌 62 巻 ( 2 ) 頁： 105 - 105 2020年3月

労働者の生活習慣指導のありかた特定健康診査による保健指導レベルと2型糖尿病発症の関連およびその人口寄与危険割合愛知職域コホート研究

金子佳世, 八谷寛, 李媛英, 上村真由, 江啓発, 平川仁尚, 内藤久雄, 太田充彦, 玉腰浩司, 青山温子

産業衛生学雑誌 62 巻 ( 2 ) 頁： 94 - 94 2020年3月

Human herpesvirus-6B infection in pediatric allogenic hematopoietic stem cell transplant patients: Risk factors and encephalitis 査読有り国際誌

Miura, H; Kawamura, Y; Hattori, F; Tanaka, M; Kudo, K; Ihira, M; Yatsuya, H; Takahashi, Y; Kojima, S; Sakaguchi, H; Yoshida, N; Hama, A; Yoshikawa, T

TRANSPLANT INFECTIOUS DISEASE 22 巻 ( 1 ) 頁： e13203 2020年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Transplant Infectious Disease

Background: Human herpesvirus-6B (HHV-6B) infection after allogenic hematopoietic stem cell transplantation (allo-HSCT) is known to be associated with post-transplant limbic encephalitis in adults. Meanwhile, the association between HHV-6B infection and central nervous system complications remains unclear in pediatric allo-HSCT patients. Methods: In this study, HHV-6B infection was monitored for more than 50 days after HSCT using virus isolation and real-time PCR. Clinical information such as patient background and encephalitis status was collected retrospectively from medical records. Risk factors for HHV-6B infection were determined by the Cox proportional hazards model, and the clinical features of HHV-6B encephalitis in pediatric allo-HSCT patients were elucidated. Results: Human herpesvirus-6B infection was observed in 74 (33.8%) of 219 patients at 3-47 days (median 18, interquartile range 13-20). Risk factors identified in multivariable analysis were hematological malignancy (hazards ratio [HR], 5.0; 95% confidence interval [CI], 2.3/12.5; P <.0001), solid tumor (HR, 4.8; CI, 1.5/16.3; P =.0104), unrelated donor (HR, 2.1; CI, 1.0/4.6; P =.0378), and sex-mismatched donor (HR 1.8; CI, 1.1/3.0; P =.0257). HHV-6B encephalitis occurred in only one of the 219 patients (0.46%); this patient demonstrated the typical clinical course of posterior reversible encephalopathy syndrome. Conclusion: Hematological malignancy, solid tumor, unrelated donor, and sex-mismatched donor were significant risk factors for HHV-6B infection after pediatric allo-HSCT. In pediatric allo-HSCT patients, the incidence of HHV-6B encephalitis was low and the clinical features differed from those in adult patients.

DOI： 10.1111/tid.13203

Association of Vegetable, Fruit, and Okinawan Vegetable Consumption With Incident Stroke and Coronary Heart Disease 査読有り Open Access

Yoshizaki, T; Ishihara, J; Kotemori, A; Yamamoto, J; Kokubo, Y; Saito, I; Yatsuya, H; Yamagishi, K; Sawada, N; Iwasaki, M; Iso, H; Tsugane, S

JOURNAL OF EPIDEMIOLOGY 30 巻 ( 1 ) 頁： 37 - 45 2020年1月

Non-High-Density Lipoprotein Cholesterol and Risk of Stroke Subtypes and Coronary Heart Disease The Japan Public Health Center-Based Prospective (JPHC) Study 査読有り

Saito, I; Yamagishi, K; Kokubo, Y; Yatsuya, H; Iso, H; Sawada, N; Inoue, M; Tsugane, S

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 27 巻 ( 4 ) 頁： 363 - 374 2020年

Depressive Tendency and the Risk of Death from Pneumonia: The JACC Study 査読有り

Tanabe, N; Seki, N; Horikawa, C; Yatsuya, H; Yamagishi, K; Iso, H; Ukawa, S; Tamakoshi, A

INTERNAL MEDICINE 59 巻 ( 24 ) 頁： 3123 - 3130 2020年

Cross-sectional association between working and depression prevalence in cancer survivors: a literature review 査読有り国際誌

Atsuhiko Ota, Kenji Kawada, Akizumi Tsutsumi, Hiroshi Yatsuya

Environmental and Occupational Health Practice 2 巻 ( 1 ) 頁： n/a - n/a 2020年

Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study 査読有り国際誌

Murai, U; Yamagishi, K; Sata, M; Kokubo, Y; Saito, I; Yatsuya, H; Ishihara, J; Inoue, M; Sawada, N; Iso, H; Tsugane, S

AMERICAN JOURNAL OF CLINICAL NUTRITION 110 巻 ( 6 ) 頁： 1449 - 1455 2019年12月

Association Between Body Mass Index and All-Cause Death in Japanese Population: Pooled Individual Participant Data Analysis of 13 Cohort Studies 査読有り Open Access

Hozawa, A; Hirata, T; Yatsuya, H; Murakami, Y; Kuriyama, S; Tsuji, I; Sugiyama, D; Satoh, A; Tanaka-Mizuno, S; Miura, K; Ueshima, H; Okamura, T

JOURNAL OF EPIDEMIOLOGY 29 巻 ( 12 ) 頁： 457 - 463 2019年12月

Diagnostic contribution of cytological examination to endobronchial ultrasound-guided transbronchial biopsy for lung malignancies 査読有り Open Access

Kajikawa, S; Imai, N; Okachi, S; Yatsuya, H; Souma, T; Watanabe, T; Goto, Y; Minezawa, T; Hashimoto, N; Imaizumi, K; Hasegawa, Y

NAGOYA JOURNAL OF MEDICAL SCIENCE 81 巻 ( 4 ) 頁： 613 - 620 2019年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nagoya Journal of Medical Science

Although endobronchial ultrasound guided transbronchial biopsy (TBB) with a guide sheath (EBUSGS) is widely used for diagnosis of peripheral pulmonary lesions, the diagnostic contribution of cytology (bronchial brushing, bronchial washing and biopsy forceps rinse) has not been established. To determine the diagnostic contribution of cytological examination to EBUS-GS-TBB, we reviewed medical records of patients with lung malignancies who had undergone TBB with EBUS-GS (EBUS-GS group, n=187) or TBB without EBUS-GS (conventional TBB [CTBB] group, n=197) at Nagoya University Hospital. Although the mean size of target lesions was significantly larger in the CTBB group than the EBUS-GS group, the total diagnostic rate was equivalent between two groups (EBUS-GS: 73.3%, CTBB: 66.0%). In the EBUS-GS group, cytological procedures increased the diagnostic rate by 9.1% (17/137), compared with only 4.1% (8/130) in the CTBB group. Sensitivity of cytology among biopsy-negative patients was significantly higher in EBUS-GS group than CTBB group (P=0.022). Furthermore, in the EBUS-GS group, among 17 patients whose malignant diagnoses could only be established cytologically, bronchial brushing contributed to the malignant diagnosis in 64.7% (11/17). These data may suggest that cytological examination, especially bronchial brushing, may be an important diagnostic contributor in EBUS-GS-TBB.

DOI： 10.18999/nagjms.81.4.613

Comparing different definitions of prediabetes with subsequent risk of diabetes: an individual participant data meta-analysis involving 76 513 individuals and 8208 cases of incident diabetes 査読有り国際共著国際誌 Open Access

Lee, CMY; Colagiuri, S; Woodward, M; Gregg, EW; Adams, R; Azizi, F; Gabriel, R; Gill, TK; Gonzalez, C; Hodge, A; Jacobs, DR ; Joseph, JJ; Khalili, D; Magliano, DJ; Mehlig, K; Milne, R; Mishra, G; Mongraw-Chaffin, M; Pasco, JA; Sakurai, M; Schreiner, PJ; Selvin, E; Shaw, JE; Wittert, G; Yatsuya, H; Huxley, RR

BMJ OPEN DIABETES RESEARCH & CARE 7 巻 ( 1 ) 頁： e000794 2019年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMJ Open Diabetes Research and Care

Objective There are currently five widely used definition of prediabetes. We compared the ability of these to predict 5-year conversion to diabetes and investigated whether there were other cut-points identifying risk of progression to diabetes that may be more useful. Research design and methods We conducted an individual participant meta-analysis using longitudinal data included in the Obesity, Diabetes and Cardiovascular Disease Collaboration. Cox regression models were used to obtain study-specific HRs for incident diabetes associated with each prediabetes definition. Harrell's C-statistics were used to estimate how well each prediabetes definition discriminated 5-year risk of diabetes. Spline and receiver operating characteristic curve (ROC) analyses were used to identify alternative cut-points. Results Sixteen studies, with 76 513 participants and 8208 incident diabetes cases, were available. Compared with normoglycemia, current prediabetes definitions were associated with four to eight times higher diabetes risk (HRs (95% CIs): 3.78 (3.11 to 4.60) to 8.36 (4.88 to 14.33)) and all definitions discriminated 5-year diabetes risk with good accuracy (C-statistics 0.79-0.81). Cut-points identified through spline analysis were fasting plasma glucose (FPG) 5.1 mmol/L and glycated hemoglobin (HbA1c) 5.0% (31 mmol/mol) and cut-points identified through ROC analysis were FPG 5.6 mmol/L, 2-hour postload glucose 7.0 mmol/L and HbA1c 5.6% (38 mmol/mol). Conclusions In terms of identifying individuals at greatest risk of developing diabetes within 5 years, using prediabetes definitions that have lower values produced non-significant gain. Therefore, deciding which definition to use will ultimately depend on the goal for identifying individuals at risk of diabetes.

DOI： 10.1136/bmjdrc-2019-000794

The association between weight fluctuation and all-cause mortality A systematic review and meta-analysis 査読有り国際共著国際誌

Zhang, Y; Hou, FF; Li, JX; Yu, HY; Li, L; Hu, SL; Shen, GD; Yatsuya, H

MEDICINE 98 巻 ( 42 ) 頁： e17513 2019年10月

Television Viewing Time and Breast Cancer Incidence or Japanese Premenopausal and Postmenopausal Women: The JACC Study 査読有り Open Access

Cao, JH; Eshak, ES; Liu, KY; Muraki, I; Cui, RZ; Iso, H; Tamakoshi, A; Mori, M; Kaneko, Y; Tsuji, I; Nakamura, Y; Yamagishi, K; Mikami, H; Kurosawa, M; Hoshiyama, Y; Tanabe, N; Tamakoshi, K; Wakai, K; Tokudome, S; Suzuki, K; Hashimoto, S; Yatsuya, H; Kikuchi, S; Wada, Y; Kawamura, T; Watanabe, Y; Ozasa, K; Mikami, K; Date, C; Sakata, K; Yoshimura, T; Fujino, Y; Shibata, A; Okamoto, N; Shio, H; Kurozawa, Y

CANCER RESEARCH AND TREATMENT 51 巻 ( 4 ) 頁： 1509 - 1517 2019年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Cancer Research and Treatment

Purpose The evidence on effects of TV viewing time among premenopausal and postmenopausal women for breast cancer risk remains controversial and limited. Materials and Methods A prospective study encompassing 33,276 (17,568 premenopausal, and 15,708 postmenopausal) women aged 40-79 years in whom TV viewing time, menstrual, and reproductive histories were determined by a self-administered questionnaire. The follow-up was from 1988 to 2009 and hazard ratios (HRs) with 95% confidence intervals (CIs) of breast cancer incidence were calculated for longer TV viewing time in reference to shorter TV viewing time by Cox proportional hazard models. Results During 16.8-year median follow-up, we found positive associations between TV viewing time and breast cancer incidence with a borderline significant trend among total women and a significant trend among postmenopausal women. Among total women, the multivariable HRs (95% CIs) for risk of breast cancer in reference to < 1.5 hr/day of TV viewing time were 0.89 (0.59-1.34) for 1.5 to < 3.0 hr/day, 1.19 (0.82-1.74) for 3.0 to < 4.5 hr/day, and 1.45 (0.91-2.32) for ≥ 4.5 hr/day (p for trend=0.053) and among postmenopausal women, the corresponding risk estimates were 1.10 (0.42-2.88), 2.54 (1.11-5.80), and 2.37 (0.92-6.10) (p for trend=0.009), respectively. Conclusion Prolonged TV viewing time was associated with increased risk of breast cancer, especially among postmenopausal women.

DOI： 10.4143/crt.2018.705

メタボリックシンドローム、空腹時血糖、腹囲身長比による6年後の2型糖尿病発症予測能査読有り

金子佳世, 八谷寛, 李媛英, 江啓発, 平川仁尚, 太田充彦, 玉腰浩司, 青山温子

日本公衆衛生学会総会抄録集 78回巻頁： 220 - 220 2019年10月

メタボリックシンドローム、空腹時血糖、腹囲身長比による6年後の2型糖尿病発症予測能

金子佳世, 八谷寛, 李媛英, 江啓発, 平川仁尚, 太田充彦, 玉腰浩司, 青山温子

日本公衆衛生学会総会抄録集 78回巻頁： 220 - 220 2019年10月

Body Mass Index and Risks of Incident Ischemic Stroke Subtypes: The Japan Public Health Center-Based Prospective (JPHC) Study. 査読有り国際誌 Open Access

Li Y, Yatsuya H, Iso H, Yamagishi K, Saito I, Kokubo Y, Sawada N, Tsugane S

Journal of epidemiology 29 巻 ( 9 ) 頁： 325 - 333 2019年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: The association of body mass index (BMI) with risks of ischemic stroke subtypes have not been established. Methods: Cumulative average BMI was calculated using self-reported body weight and height obtained from baseline (Cohort I in 1990, and Cohort II from 1993-1994) and 5- and 10-year questionnaire surveys of Japan Public Health Center-based prospective (JPHC) study. A total of 42,343 men and 46,413 women aged 40-69 years were followed-up for the incidence of lacunar, large-artery occlusive, and cardioembolic strokes. A sub-distribution hazard model was used to estimate subdistribution hazard ratios (SHRs) and the 95% confidence intervals (CIs). Results: During a median of 20.0 years of follow-up, we documented 809 and 481 lacunar, 395 and 218 large-artery occlusive, and 568 and 298 cardioembolic strokes in men and women, respectively. After adjustment for baseline age, updated smoking, alcohol consumption, leisure-time physical activity, and histories of hypertension, dyslipidemia, and diabetes mellitus, cumulative average BMI was positively linearly associated with lacunar (trend P = 0.007), large-artery occlusive (trend P = 0.002), and cardioembolic (trend P < 0.001) strokes in men, and with lacunar (trend P < 0.001) and large-artery occlusive (trend P = 0.003) strokes in women. There were approximately two-fold excess risk of cardioembolic stroke in both sexes and of lacunar and large-artery occlusive strokes in women for cumulative average BMI ≥30 kg=m2 compared to BMI 23-<25 kg=m2. Conclusion: Cumulative average BMI showed a positive linear effect on sub-distribution hazards of lacunar, large-artery occlusive, and cardioembolic strokes in both sexes, except for cardioembolic stroke in women.

DOI： 10.2188/jea.JE20170298

労働災害における休業見込期間と実休業日数の差異労働者死傷病報告と実休業日数との乖離

加藤善士, 太田充彦, 八谷寛

労働安全衛生研究 12 巻 ( 3 ) 頁： 173 - 179 2019年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：(独)労働者健康安全機構労働安全衛生総合研究所

労働基準監督署では，労働災害の重篤度を休業見込期間により判断し，労働災害防止施策を展開している．しかし，労働災害の休業が当初の休業見込期間を超えて長期に及ぶことがある．的確な労働災害防止施策を展開するためには，休業期間を早期に正確に把握することが重要となる．そこで某労働基準監督署管内の過去3 年間に発生した労働災害1,672件(男性1,204名，女性468名)について，事業場から報告される労働者死傷病報告と労働者災害補償内容を対比し，休業見込期間と実際の実休業日数の乖離状況を調べ，業種，事業場規模，性別，年齢，業務経験期間，平均賃金との関連を検討した．休業見込期間を超えて実際に休業した者の割合は男性で71.2%，女性で63.9%であった．休業見込期間（中央値：男性30日，女性28日）と実休業日数（中央値：男性50日，女性39日）は男性の方が長かった．休業見込期間を超えて休業する者の割合は，男性において事業場業種，事業場規模，年齢で有意な差が認められた．また，実休業日数／休業見込期間比の中央値は男性1.38，女性1.20と男女間で有意な差があった．労働災害の重篤度を休業見込期間で判断することは，重篤度を過小評価する可能性が高く，実休業日数が休業見込期間を超える割合には，男女で差があった．

DOI： 10.2486/josh.JOSH-2019-0009-CHO

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J05150&link_issn=&doc_id=20191002450005&doc_link_id=10.2486%2Fjosh.JOSH-2019-0009-CHO&url=https%3A%2F%2Fdoi.org%2F10.2486%2Fjosh.JOSH-2019-0009-CHO&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

エチオピア北部の公務員における糖尿病および前糖尿病の危険因子(Risk factors of diabetes and prediabetes among public employees in northern Ethiopia) 国際共著

He Yupeng, Chiang Chifa, Gebremariam Lemlem W., Yatsuya Hiroshi, Hirakawa Yoshihisa, Aoyama Atsuko

国際保健医療 34 巻 ( 3 ) 頁： 140 - 141 2019年9月

High-fat and high-cholesterol diet decreases phosphorylated inositol-requiring kinase-1 and inhibits autophagy process in rat liver 査読有り国際誌 Open Access

Naito, H; Yoshikawa-Bando, Y; Yuan, Y; Hashimoto, S; Kitamori, K; Yatsuya, H; Nakajima, T

SCIENTIFIC REPORTS 9 巻 ( 1 ) 頁： 12514 - 12514 2019年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

Precise molecular pathways involved in the progression of non-alcoholic steatohepatitis (NASH) remain to be elucidated. As Mallory–Denk bodies were occasionally observed in the enlarged hepatocytes in NASH model rat (SHRSP5/Dmcr) fed high-fat and high-cholesterol (HFC) diet, we aimed to clarify the roles of autophagy and endoplasmic reticulum (ER) stress in NASH progression. Male SHRSP5/Dmcr were randomly divided into 4 groups. Two groups were fed a control diet; the other two groups were fed a HFC diet for 2 and 8 weeks, respectively. The HFC diet increased the autophagy-related proteins levels and microtubule-associated protein 1 light chain 3-II/I ratio after 2 and 8 weeks, respectively. However, regarding ER stress-related proteins, the HFC diet decreased the levels of phosphorylated (p-) inositol-requiring kinase-1 (p-IRE-1) and p-protein kinase RNA-like ER kinase after 2 weeks. Additionally, the HFC diet increased anti-ubiquitin-positive cells and the level of the autophagy substrate p62, suggesting that the HFC diet induced dysfunction in ubiquitin-dependent protein degradation pathways. In conclusion, the HFC diet arrested the autophagy process in the liver; this was particularly associated with decreases in p-IRE-1 expression.

DOI： 10.1038/s41598-019-48973-w

Automated Feedback Messages With Shichifukujin Characters Using IoT System-Improved Glycemic Control in People With Diabetes: A Prospective, Multicenter Randomized Controlled Trial. 査読有り国際誌

Kobayashi T, Tsushita K, Nomura E, Muramoto A, Kato A, Eguchi Y, Onoue T, Goto M, Muto S, Yatsuya H, Arima H

Journal of diabetes science and technology 13 巻 ( 4 ) 頁： 796 - 798 2019年7月

Associations of Daily Walking Time With Pneumonia Mortality Among Elderly Individuals With or Without a Medical History of Myocardial Infarction or Stroke: Findings From the Japan Collaborative Cohort Study 査読有り Open Access

Ukawa, S; Zhao, WJ; Yatsuya, H; Yamagishi, K; Tanabe, N; Iso, H; Tamakoshi, A; Mori, M; Sakauchi, F; Motohashi, Y; Tsuji, I; Nakamura, Y; Iso, H; Mikami, H; Kurosawa, M; Hoshiyama, Y; Tanabe, N; Tamakoshi, K; Wakai, K; Tokudome, S; Suzuki, K; Hashimoto, S; Kikuchi, S; Wada, Y; Kawamura, T; Watanabe, Y; Ozasa, K; Miki, T; Date, C; Sakata, K; Kurozawa, Y; Yoshimura, T; Fujino, Y; Shibata, A; Okamoto, N; Shio, H

JOURNAL OF EPIDEMIOLOGY 29 巻 ( 6 ) 頁： 233 - 237 2019年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: The association between daily walking and pneumonia mortality, stratified by the presence of disease conditions, such as myocardial infarction (MI) or stroke, was investigated. Methods: The study participants were 22,280 Japanese individuals (9,067 men and 13,213 women) aged 65-79 years. Inverse propensity weighted competing risk model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for pneumonia mortality. Results: After a median of 11.9 years of follow-up, 1,203 participants died of pneumonia. Participants who did not have a history of MI or stroke and who walked for 1 hour=day or more were less likely to die from pneumonia (HR 0.90; 95% CI, 0.82-0.98) than those walked for 0.5 hours=day. A similar inverse association of pneumonia and walking (0.5 hours=day) was observed among participants with a history of MI (HR 0.66; 95% CI, 0.48-0.90). Among the participants with a history of stroke, those who walked for 0.6-0.9 hours=day were less likely to die because of pneumonia (HR 0.65; 95% CI, 0.43-0.98). Conclusions: Regular walking for?1 hour=day may reduce the risk of pneumonia mortality in elderly individuals with or without cardiovascular disease history.

DOI： 10.2188/jea.JE20170341

Socioeconomic and lifestyle factors associated with depressive tendencies in general Japanese men and women: NIPPON DATA2010 査読有り国際誌 Open Access

Suzuki, H; Kadota, A; Okuda, N; Hayakawa, T; Nishi, N; Nakamura, Y; Arima, H; Miyagawa, N; Satoh, A; Miyamatsu, N; Yanagita, M; Yatsuya, H; Yamagata, Z; Ohkubo, T; Okamura, T; Ueshima, H; Okayama, A; Miura, K

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE 24 巻 ( 1 ) 頁： 37 - 37 2019年5月

Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 査読有り国際共著国際誌 Open Access

Johnson, CO; Nguyen, M; Roth, GA; Nichols, E; Alam, T; Abate, D; Abd-Allah, F; Abdelalim, A; Abraha, HN; Abu-Rmeileh, NM; Adebayo, OM; Adeoye, AM; Agarwal, G; Agrawal, S; Aichour, AN; Aichour, I; Aichour, MTE; Alahdab, F; Ali, R; Alvis-Guzman, N; Anber, NH; Anjomshoa, M; Arabloo, J; Arauz, A; Ärnlöv, J; Arora, A; Awasthi, A; Banach, M; Barboza, MA; Barker-Collo, SL; Bärnighausen, TW; Basu, S; Belachew, AB; Belayneh, YM; Bennett, DA; Bensenor, IM; Bhattacharyya, K; Biadgo, B; Bijani, A; Bikbov, B; Bin Sayeed, MS; Butt, ZA; Cahuana-Hurtado, L; Carrero, JJ; Carvalho, F; Castañeda-Orjuela, CA; Castro, F; Catalá-López, F; Chaiah, Y; Chiang, PPC; Choi, JYJ; Christensen, H; Chu, DT; Cortinovis, M; Damasceno, AAM; Dandona, L; Dandona, R; Daryani, A; Davletov, K; De Courten, B; De la Cruz-Góngora, V; Degefa, MG; Dharmaratne, SD; Diaz, D; Dubey, M; Duken, EE; Edessa, D; Endres, M; Faraon, EJA; Farzadfar, F; Fernandes, E; Fischer, F; Flor, LS; Ganji, M; Gebre, AK; Gebremichael, TG; Geta, B; Gezae, KE; Gill, PS; Gnedovskaya, EV; Gómez-Dantés, H; Goulart, AC; Grosso, G; Guo, YM; Gupta, R; Haj-Mirzaian, A; Haj-Mirzaian, A; Hamidi, S; Hankey, GJ; Hassen, HY; Hay, SI; Hegazy, MI; Heidari, B; Herial, NA; Hosseini, MA; Hostiuc, S; Irvani, SSN; Islam, SMS; Jahanmehr, N; Javanbakht, M; Jha, RP; Jonas, JB; Józwiak, JJ; Jürisson, M; Kahsay, A; Kalani, R; Kalkonde, Y; Kamil, TA; Kanchan, T; Karch, A; Karimi, N; Karimi-Sari, H; Kasaeian, A; Kassa, TD; Kazemeini, H; Kefale, AT; Khader, YS; Khalil, IA; Khan, EA; Khang, YH; Khubchandani, J; Kim, D; Kim, YJ; Kisa, A; Kivimäki, M; Koyanagi, A; Krishnamurthi, RK; Kumar, GA; Lafranconi, A; Lewington, S; Li, SS; Lo, WD; Lopez, AD; Lorkowski, S; Lotufo, PA; Mackay, MT; Majdan, M; Majdzadeh, R; Majeed, A; Malekzadeh, R; Manafi, N; Mansournia, MA; Mehndiratta, MM; Mehta, V; Mengistu, G; Meretoja, A; Meretoja, TJ; Miazgowski, B; Miazgowski, T; Miller, TR; Mirrakhimov, EM; Mohajer, B; Mohammad, Y; Mohammadoo-Khorasani, M; Mohammed, S; Mohebi, F; Mokdad, AH; Mokhayeri, Y; Moradi, G; Morawska, L; Velásquez, IM; Mousavi, SM; Muhammed, OSS; Muruet, W; Naderi, M; Naghavi, M; Naik, G; Nascimento, BR; Negoi, RI; Nguyen, CT; Nguyen, LH; Nirayo, YL; Norrving, B; Noubiap, JJ; Ofori-Asenso, R; Ogbo, FA; Olagunju, AT; Olagunju, TO; Owolabi, MO; Pandian, JD; Patel, S; Perico, N; Piradov, MA; Polinder, S; Postma, MJ; Poustchi, H; Prakash, V; Qorbani, M; Rafiei, A; Rahim, F; Rahimi, K; Rahimi-Movaghar, V; Rahman, M; Rahman, MA; Reis, C; Remuzzi, G; Renzaho, AMN; Ricci, S; Roberts, NLS; Robinson, SR; Roever, L; Roshandel, G; Sabbagh, P; Safari, H; Safari, S; Safiri, S; Sahebkar, A; Zahabi, SS; Samy, AM; Santalucia, P; Santos, IS; Santos, JV; Milicevic, MMS; Sartorius, B; Sawant, AR; Schutte, AE; Sepanlou, SG; Shafieesabet, A; Shaikh, MA; Shams-Beyranvand, M; Sheikh, A; Sheth, KN; Shibuya, K; Shigematsu, M; Shin, MJ; Shiue, I; Siabani, S; Sobaih, BH; Sposato, LA; Sutradhar, I; Sylaja, PA; Szoeke, CEI; Ao, BJT; Temsah, MH; Temsah, O; Thrift, AG; Tonelli, M; Topor-Madry, R; Tran, BX; Tran, KB; Truelsen, TC; Tsadik, AG; Ullah, I; Uthman, OA; Vaduganathan, M; Valdez, PR; Vasankari, TJ; Vasanthan, R; Venketasubramanian, N; Vosoughi, K; Vu, GT; Waheed, Y; Weiderpass, E; Weldegwergs, KG; Westerman, R; Wolfe, CDA; Wondafrash, DZ; Xu, GL; Yadollahpour, A; Yamada, T; Yatsuya, H; Yimer, EM; Yonemoto, N; Yousefifard, M; Yu, CH; Zaidi, Z; Zamani, M; Zarghi, A; Zhang, YQ; Zodpey, S; Feigin, VL; Vos, T; Murray, CJL

LANCET NEUROLOGY 18 巻 ( 5 ) 頁： 439 - 458 2019年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Lancet Neurology

Background: Stroke is a leading cause of mortality and disability worldwide and the economic costs of treatment and post-stroke care are substantial. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic, comparable method of quantifying health loss by disease, age, sex, year, and location to provide information to health systems and policy makers on more than 300 causes of disease and injury, including stroke. The results presented here are the estimates of burden due to overall stroke and ischaemic and haemorrhagic stroke from GBD 2016. Methods: We report estimates and corresponding uncertainty intervals (UIs), from 1990 to 2016, for incidence, prevalence, deaths, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs). DALYs were generated by summing YLLs and YLDs. Cause-specific mortality was estimated using an ensemble modelling process with vital registration and verbal autopsy data as inputs. Non-fatal estimates were generated using Bayesian meta-regression incorporating data from registries, scientific literature, administrative records, and surveys. The Socio-demographic Index (SDI), a summary indicator generated using educational attainment, lagged distributed income, and total fertility rate, was used to group countries into quintiles. Findings: In 2016, there were 5·5 million (95% UI 5·3 to 5·7) deaths and 116·4 million (111·4 to 121·4) DALYs due to stroke. The global age-standardised mortality rate decreased by 36·2% (−39·3 to −33·6) from 1990 to 2016, with decreases in all SDI quintiles. Over the same period, the global age-standardised DALY rate declined by 34·2% (−37·2 to −31·5), also with decreases in all SDI quintiles. There were 13·7 million (12·7 to 14·7) new stroke cases in 2016. Global age-standardised incidence declined by 8·1% (−10·7 to −5·5) from 1990 to 2016 and decreased in all SDI quintiles except the middle SDI group. There were 80·1 million (74·1 to 86·3) prevalent cases of stroke globally in 2016; 41·1 million (38·0 to 44·3) in women and 39·0 million (36·1 to 42·1) in men. Interpretation: Although age-standardised mortality rates have decreased sharply from 1990 to 2016, the decrease in age-standardised incidence has been less steep, indicating that the burden of stroke is likely to remain high. Planned updates to future GBD iterations include generating separate estimates for subarachnoid haemorrhage and intracerebral haemorrhage, generating estimates of transient ischaemic attack, and including atrial fibrillation as a risk factor. Funding: Bill & Melinda Gates Foundation

DOI： 10.1016/S1474-4422(19)30034-1

Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 査読有り国際共著国際誌

Feigin, VL; Nichols, E; Alam, T; Bannick, MS; Beghi, E; Blake, N; Culpepper, WJ; Dorsey, ER; Elbaz, A; Ellenbogen, RG; Fisher, JL; Fitzmaurice, C; Giussani, G; Glennie, L; James, SL; Johnson, CO; Kassebaum, NJ; Logroscino, G; Marin, B; Mountjoy-Venning, WC; Nguyen, M; Ofori-Asenso, R; Patel, AP; Piccininni, M; Roth, GA; Steiner, TJ; Stovner, LJ; Szoeke, CEI; Theadom, A; Vollset, SE; Wallin, MT; Wright, C; Zunt, JR; Abbasi, N; Abd-Allah, F; Abdelalim, A; Abdollahpour, I; Aboyans, V; Abraha, HN; Acharya, D; Adamu, AA; Adebayo, OM; Adeoye, AM; Adsuar, JC; Afarideh, M; Agrawal, S; Ahmadi, A; Ahmed, MB; Aichour, AN; Aichour, I; Aichour, MTE; Akinyemi, RO; Akseer, N; Al-Eyadhy, A; Salman, RA; Alahdab, F; Alene, KA; Aljunid, SM; Altirkawi, K; Alvis-Guzman, N; Anber, NH; Antonio, CAT; Arabloo, J; Aremu, O; Ärnlöv, J; Asayesh, H; Asghar, RJ; Atalay, HT; Awasthi, A; Quintanilla, BPA; Ayuk, TB; Badawi, A; Banach, M; Banoub, JAM; Barboza, MA; Barker-Collo, SL; Bärnighausen, TW; Baune, BT; Bedi, N; 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LANCET NEUROLOGY 18 巻 ( 5 ) 頁： 459 - 480 2019年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Lancet Neurology

Background: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders. Methods: We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach. Findings: Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247–308]) and second leading cause of deaths (9·0 million [8·8–9·4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34–44] and DALYs by 15% [9–21]) whereas their age-standardised rates decreased (deaths by 28% [26–30] and DALYs by 27% [24–31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42·2% [38·6–46·1]), migraine (16·3% [11·7–20·8]), Alzheimer's and other dementias (10·4% [9·0–12·1]), and meningitis (7·9% [6·6–10·4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1·12 [1·05–1·20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0·7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88·8% (86·5–90·9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer's disease and other dementias (22·3% [11·8–35·1] of DALYs are risk attributable) and idiopathic epilepsy (14·1% [10·8–17·5] of DALYs are risk attributable). Interpretation: Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies. Funding: Bill & Melinda Gates Foundation.

DOI： 10.1016/S1474-4422(18)30499-X

Association of gamma-glutamyl transferase and alanine aminotransferase with type 2 diabetes mellitus incidence in middle-aged Japanese men: 12-year follow up 査読有り Open Access

Kaneko, K; Yatsuya, H; Li, YY; Uemura, M; Chiang, CF; Hirakawa, Y; Ota, A; Tamakoshi, K; Aoyama, A

JOURNAL OF DIABETES INVESTIGATION 10 巻 ( 3 ) 頁： 837 - 845 2019年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Diabetes Investigation

Aims/Introduction: To prospectively investigate whether simultaneous elevation of gamma-glutamyl transferase (GGT) and alanine aminotransferase (ALT) is associated with the increase of type 2 diabetes mellitus incidence independent of alcohol drinking, body mass index and triglycerides. Methods: A total of 2,775 Japanese male workers who had no history of type 2 diabetes mellitus were followed. High GGT and ALT were defined as the top tertiles (GGT cutpoint: 49 IU/L, ALT cutpoint: 28 IU/L). Three groups were created using these dichotomized GGT and ALT cutpoints: both low, either high or both high. Multivariable Cox proportional hazards models were carried out adjusted for potential confounding factors. Results: A total of 276 type 2 diabetes mellitus cases were identified during 12 years (27,040 person-years) of follow up. Participants with simultaneously elevated GGT and ALT had a significantly higher incidence of type 2 diabetes mellitus, even after adjustment for fasting insulin and fasting blood glucose compared with the group without GGT or ALT elevation. Similar associations were observed in non- or light-to-moderate alcohol drinkers, as well as in participants with normal weight. However, the association was weaker in participants with triglycerides <150 mg/dL. We then evaluated whether the addition of GGT and ALT would improve the prediction of type 2 diabetes mellitus incidence, and found that their inclusion significantly increased the C-statistic, net reclassification improvement and integrated discrimination improvement. Conclusions: Simultaneous elevation of GGT and ALT was significantly associated with type 2 diabetes mellitus incidence, independent of potential confounding factors, including alcohol drinking and obesity, although the association might require concomitant elevation of triglycerides. Inclusion of GGT and ALT improved type 2 diabetes mellitus risk prediction.

DOI： 10.1111/jdi.12930

Working Hours and Risk of Acute Myocardial Infarction and Stroke Among Middle-Aged Japanese Men - The Japan Public Health Center-Based Prospective Study Cohort II 査読有り Open Access

Hayashi, R; Iso, H; Yamagishi, K; Yatsuya, H; Saito, I; Kokubo, Y; Eshak, ES; Sawada, N; Tsugane, S

CIRCULATION JOURNAL 83 巻 ( 5 ) 頁： 1072 - 1079 2019年5月

特定保健指導レベルと2型糖尿病発症の関連・その臨床疫学的指標愛知職域コホート

金子佳世, 八谷寛, 李媛英, 上村真由, 江啓発, 平川仁尚, 内藤久雄, 太田充彦, 玉腰浩司, 青山温子

産業衛生学雑誌 61 巻 ( 臨増 ) 頁： 321 - 321 2019年5月

トリクロロエチレンによるCYP2E1抗体上昇とhypersensitivity syndromeとの関係

那須民江, 王海蘭, 袁媛, 内藤久雄, 伊藤由起, 八谷寛, 上島通浩

産業衛生学雑誌 61 巻 ( 臨増 ) 頁： 332 - 332 2019年5月

Recent Status and Methodological Quality of Return-to-Work Rates of Cancer Patients Reported in Japan: A Systematic Review 査読有り国際誌 Open Access

Ota, A; Fujisawa, A; Kawada, K; Yatsuya, H

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 16 巻 ( 8 ) 2019年4月

Validation of the Japanese Version of the Yale Food Addiction Scale 2.0 (J-YFAS 2.0) 査読有り国際共著 Open Access

Khine, MT; Ota, A; Gearhardt, AN; Fujisawa, A; Morita, M; Minagawa, A; Li, YY; Naito, H; Yatsuya, H

NUTRIENTS 11 巻 ( 3 ) 頁： 687 - 687 2019年3月

Multicenter feasibility study of bowel preparation with castor oil for colon capsule endoscopy 査読有り国際誌

Ohmiya, N; Hotta, N; Mitsufuji, S; Nakamura, M; Omori, T; Maeda, K; Okuda, K; Yatsuya, H; Tajiri, H

DIGESTIVE ENDOSCOPY 31 巻 ( 2 ) 頁： 164 - 172 2019年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Digestive Endoscopy

Background and Aim: Extensive use of laxatives and incomplete excretion rates are problematic for colon capsule endoscopy (CCE). The aim of the present study was to determine the effectiveness of castor oil as a booster. Methods: At four Japanese hospitals, 319 examinees undergoing CCE were enrolled retrospectively. Before and after the introduction of castor oil, other preparation reagents were unchanged. Results: Of 319 examinees who underwent CCE, 152 and 167 examinees took regimens with castor oil (between November 2013 and June 2016) and without castor oil (between October 2015 and September 2017), respectively. Capsule excretion rates within its battery life in the groups with and without castor oil were 97% and 81%, respectively (P < 0.0001). Multivariate analysis showed that ages younger than 65 years (adjusted odds ratio [OR], 3.00; P = 0.0048), male gender (adjusted OR, 3.20; P = 0.0051), and use of castor oil (adjusted OR, 6.29; P = 0.0003) were predictors of capsule excretion within its battery life. Small bowel transit time was shorter and total volume of lavage and fluid intake was lower with castor oil than without (P = 0.0154 and 0.0013, respectively). Overall adequate cleansing level ratios with and without castor oil were 74% and 83%, respectively (P = 0.0713). Per-examinee sensitivity for polyps ≥6 mm with and without castor oil was 83% and 85%, respectively, with specificities of 80% and 78%, respectively. Conclusion: Bowel preparation with castor oil was effective for improving capsule excretion rate and reducing liquid loading.

DOI： 10.1111/den.13259

Prevalence and Correlates of Dyslipidemia Among Men and Women in Palau: Findings of the Palau STEPS Survey 2011-2013 査読有り国際共著 Open Access

Cui, MS; Chiang, CF; Cui, RZ; Honjo, K; Yatsuya, H; Watson, BM; Ikerdeu, E; Mita, T; Madraisau, S; Aoyama, A; Iso, H

JOURNAL OF EPIDEMIOLOGY 29 巻 ( 3 ) 頁： 97 - 103 2019年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: Epidemiological evidence of dyslipidemia in Pacific Island countries is limited despite the knowledge that non-communicable diseases have a high burden in the region. We aimed to examine the prevalence and correlates of dyslipidemia among residents of Palau. Methods: The Palau STEPwise approach to Surveillance (STEPS), which was conducted from 2011 through 2013, comprised three parts: behavioral risk factors; physical measurements; and biochemical tests, covering areas such as blood lipids. We used STEPS-generated data to perform a cross-sectional study of 2,184 randomly selected Palau residents, comprising Palauans and non-Palauans aged 25–64 years. Results: The age-adjusted mean BMI was 29.3 kg/m 2 in men and 29.9 kg/m 2 in women; age-adjusted mean triglycerides value was 182 mg/dL in men and 166 mg/dL in women; and age-adjusted mean cholesterol was 178 mg/dL in men and 183 mg/dL in women. The prevalence of overweight/obesity (BMI ≥25 kg/m 2 ) was 75% in men and 76% in women, and those of hypertriglyceridemia (triglycerides ≥150 mg/dL) and hypercholesterolemia (total cholesterol ≥200 mg/dL) were 48% in men and 41% in women and 18% in men and 23% in women, respectively. Mean values of total cholesterol were 177 mg/dL in Palauan men and 182 mg/dL in non-Palauan men. Mean values of triglycerides were 171 mg/dL in Palauan women and 150 mg/dL in non-Palauan women. Women living in rural areas showed a higher mean value of total cholesterol than those in urban areas. Conclusion: We found a high mean BMI and high prevalence of overweight/obesity and hypertriglyceridemia, but low mean total cholesterol and a low prevalence of hypercholesterolemia in Palau. Lipid profiles varied by age, ethnicity, and living area.

DOI： 10.2188/jea.JE20170127

Sleep duration and risk of breast cancer: The JACC Study 査読有り

Cao, JH; Eshak, ES; Liu, KY; Muraki, I; Cui, RZ; Iso, H; Tamakoshi, A; Tamakoshi, A; Mori, M; Kaneko, Y; Tsuji, I; Nakamura, Y; Yamagishi, K; Mikami, H; Kurosawa, M; Hoshiyama, Y; Tanabe, N; Tamakoshi, K; Wakai, K; Tokudome, S; Suzuki, K; Hashimoto, S; Yatsuya, H; Kikuchi, S; Wada, Y; Kawamura, T; Watanabe, Y; Ozasa, K; Mikami, K; Date, C; Sakata, K; Kurozawa, Y; Yoshimura, T; Fujino, Y; Shibata, A; Okamoto, N; Shio, H

BREAST CANCER RESEARCH AND TREATMENT 174 巻 ( 1 ) 頁： 219 - 225 2019年2月

Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium 査読有り国際共著国際誌 Open Access

Inker, LA; Grams, ME; Levey, AS; Coresh, J; Cirillo, M; Collins, JF; Gansevoort, RT; Gutierrez, OM; Hamano, T; Heine, GH; Ishikawa, S; Jee, SH; Kronenberg, F; Landray, MJ; Miura, K; Nadkarni, GN; Peralta, CA; Rothenbacher, D; Schaeffner, E; Sedaghat, S; Shlipak, MG; Zhang, LX; van Zuilen, AD; Hallan, S; Kovesdy, CP; Woodward, M; Levin, A; Astor, B; Appel, LJ; Greene, T; Chen, TK; Chalmers, J; Arima, H; Perkovic, V; Yatsuya, H; Tamakoshi, K; Li, YY; Hirakawa, Y; Matsushita, K; Grams, M; Sang, YY; Polldnghorne, K; Chadban, S; Atkins, R; Djurdjev, O; Liu, LS; Zhao, MH; Wang, F; Wang, JW; Ebert, N; Martus, P; Tang, ML; Heine, G; Emrich, I; Seiler, S; Zawada, A; Nally, J; Navaneethan, SD; Schold, JD; Zhao, MH; Sarnak, MJ; Katz, R; Hiramoto, J; Iso, H; Yamagishi, K; Umesawa, M; Murald, I; Fukagawa, M; Maruyama, S; Hasegawa, T; Fujii, N; Wheeler, DC; Emberson, J; Townend, J; Landray, M; Brenner, H; Schöttker, B; Saum, KU; Fox, C; Hwang, SJ; Köttgen, A; Schneider, MP; Eckardt, KU; Green, JA; Kirchner, HL; Chang, AR; Ho, K; Ito, S; Miyazaki, M; Nakayama, M; Yamada, G; Irie, F; Sairenchi, T; Yano, Y; Kotani, K; Nakamura, T; Kimm, H; Mok, Y; Chodick, G; Shalev, V; Wetzels, JFM; Blankestijn, PJ; van den Brand, JA; Sarnak, M; Peralta, C; Kollerits, B; Ritz, E; Nitsch, D; Roderick, P; Fletcher, A; Bottinger, E; Ellis, SB; Nadukuru, R; Ueshima, H; Okayama, A; Miura, K; Tanaka, S; Okamura, T; Kadota, A; Kenealy, T; Elley, CR; Drury, PL; Ohkubo, T; Asayama, K; Metold, H; Kikuya, M; Nelson, RG; Knowler, WC; Bakker, SJL; Hak, E; Heerspink, HJL; Brunskill, NJ; Major, RW; Shepherd, D; Medcalf, JF; Bernardo, R; Jassal, SK; Bergstrom, J; Ix, JH; Barrett-Connor, E; Kalantar-Zadeh, K; Sumida, K; Muntner, P; Warnock, D; McClellan, W; de Zeeuw, D; Brenner, B; Ikram, MA; Hoorn, EJ; Dehghan, A; Carrero, JJ; Gasparini, A; Wettermark, B; Elinder, CG; Wong, TY; Sabanayagam, C; Cheng, CY; Sokor, RBBMA; Visseren, FLJ; Evans, M; Segelmark, M; Stendahl, M; Schön, S; Tangri, N; Sud, M; Naimark, DM; Wen, CP; Tsao, CK; Tsai, MK; Chen, CH; Konta, T; Hirayama, A; Ichikawa, K; Lannfelt, L; Larsson, A; Ärnlöv, J; Bilo, HJG; Landman, GWD; van Hateren, KJJ; Kleefstra, N; Hallan, S; Ballew, SH; Chen, JS; Kwak, L; Surapaneni, A

AMERICAN JOURNAL OF KIDNEY DISEASES 73 巻 ( 2 ) 頁： 206 - 217 2019年2月

Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium 査読有り国際共著 Open Access

Chang, AR; Grams, ME; Ballew, SH; Bilo, H; Correa, A; Evans, M; Gutierrez, OM; Hosseinpanah, F; Iseki, K; Kenealy, T; Klein, B; Kronenberg, F; Lee, BJ; Li, YY; Miura, K; Navaneethan, SD; Roderick, PJ; Valdivielso, JM; Visseren, FLJ; Zhang, LX; Gansevoort, RT; Hallan, SI; Levey, AS; Matsushita, K; Shalev, V; Woodward, M; Astor, B; Appel, L; Greene; Chen, T; Chalmers, J; Woodward, M; Arima, H; Perkovic, V; Yatsuya, H; Tamakoshi, K; Li, Y; Hirakawa, Y; Coresh, J; Matsushita, K; Grams, M; Sang, Y; Polkinghorne, K; Chadban, S; Atkins, R; Levin, A; Djurdjev, O; Dam, B; Klein, R; Klein, B; Lee, K; Zhang, LX; Liu, LS; Zhao, MH; Wang, F; Wang, JW; Levin, A; Djurdjev, O; Tang, M; Heine, G; Emrich, I; Zawada, A; Bauer, L; Nally, J; Navaneethan, S; Schold, J; Zhang, LX; Zhao, MH; Wang, F; Wang, JW; Shlipak, M; Sarnak, M; Katz, R; Hiramoto, J; Iso, H; Yamagishi, K; Umesawa, M; Muraki, I; Fukagawa, M; Maruyama, S; Hamano, T; Hasegawa, T; Fujii, N; Jafar, T; Hatcher, J; Poulter, N; Chaturvedi, N; Wheeler, D; Emberson, J; Townend, J; Landray, M; Hermann; Brenner; Schöttker, B; Saum, KU; Rothenbacher, D; Fox, C; Hwang, SJ; Köttgen, A; Kronenberg, F; Schneider, MP; Eckardt, KU; Green, J; Kirchner, HL; Chang, AR; Ito, S; Miyazaki, M; Nakayama, M; Yamada, G; Cirillo, M; Hallan, S; Romundstad, S; Ovrehus, M; Langlo, KA; Irie, F; Sairenchi, T; Correa, A; Rebholz, CM; Young, B; Boulware, LE; Ishikawa, S; Yano, Y; Kotani, K; Nakamura, T; Jee, SH; Kimm, H; Mok, Y; Lee, BJ; Chodick, G; Shalev, V; Wetzels, JFM; Blankestijn, PJ; van Zuilen, AD; Bots, M; Sarnak, M; Inker, L; Shlipak, M; Sarnak, M; Katz, R; Peralta, C; Kronenberg, F; Kollerits, B; Ritz, E; Nitsch, D; Roderick, P; Fletcher, A; Bottinger, E; Nadkarni, GN; Ellis, SB; Nadukuru, R; Valdivielso, JM; Fernandez, E; Betriu, A; Bermudez-Lopez, M; Stengel, B; Metzger, M; Flamant, M; Houillier, P; Haymann, JP; Froissart, M; Sang, YY; Ueshima, H; Okayama, A; Miura, K; Tanaka, S; Ueshima, H; Okamura, T; Miura, K; Tanaka, S; Kenealy, T; Elley, CR; Collins, JF; Drury, PL; Ohkubo, T; Asayama, K; Metoki, H; Kikuya, M; Nakayama, M; Iseki, K; Iseki, C; Nelson, RG; Knowler, WC; Gansevoort, RT; Bakker, SJL; Heerspink, HJL; Brunskill, N; Major, R; Shepherd, D; Medcalf, J; Bernardo, R; Jassal, SK; Bergstrom, J; Joachim, H; Barrett-Connor, E; Kovesdy, C; Kalantar-Zadeh, K; Sumida, K; Muntner, P; Warnock, D; Judd, S; Panwar, B; Heerspink, HJL; de Zeeuw, D; Brenner, B; Sedaghat, S; Ikram, MA; Hoorn, EJ; Dehghan, A; Wong, TY; Sabanayagam, C; Cheng, CY; Binte, RB; Sokor, MA; Visseren, FLJ; Evans, M; Segelmark, M; Stendahl, M; Schön, S; Tangri, N; Sud, M; Naimark, D; Wen, CP; Tsao, K; Tsai, MK; Chen, CH; Konta, T; Hirayama, A; Ichikawa, K; Hosseinpanah, F; Hadaegh, F; Mirbolouk, M; Azizi, F; Solbu, MD; Jenssen, TG; Eriksen, BO; Eggen, AE; Lannfelt, L; Larsson, A; Ärnlöv, J; Bilo, HJG; Landman, GWD; Van Hateren, KJJ; Kleefstra, N; Coresh, J; Gansevoort, RT; Grams, ME; Hallan, S; Kovesdy, CP; Levey, AS; Matsushita, K; Shalev, V; Woodward, M; Ballew, SH; Chen, JS; Coresh, J; Grams, ME; Kwak, L; Matsushita, K; Sang, YY; Surapaneni, A; Woodward, M

BMJ-BRITISH MEDICAL JOURNAL 364 巻 2019年1月

Lifetime Risk of Stroke and Coronary Heart Disease Deaths According to Blood Pressure Level: EPOCH-JAPAN (Evidence for Cardiovascular Prevention From Observational Cohorts in Japan) 査読有り国際誌 Open Access

Satoh, M; Ohkubo, T; Asayama, K; Murakami, Y; Sugiyama, D; Yamada, M; Saitoh, S; Sakata, K; Irie, F; Sairenchi, T; Ishikawa, S; Kiyama, M; Ohnishi, H; Miura, K; Imai, Y; Ueshima, H; Okamura, T; Iso, H; Kitamura, A; Ninomiya, T; Kiyohara, Y; Nakagawa, H; Nakayama, T; Okayama, A; Sairenchi, T; Tamakoshi, A; Tsuji, I; Miyamoto, Y; Ishikawa, S; Yatsuya, H; Okamura, T

HYPERTENSION 73 巻 ( 1 ) 頁： 52 - 59 2019年1月

Smoking results in accumulation of ectopic fat in the liver 査読有り国際誌

Kato, A; Li, YY; Ota, A; Naito, H; Yamada, H; Nihashi, T; Hotta, Y; Chiang, C; Hirakawa, Y; Aoyama, A; Tamakoshi, K; Yatsuya, H

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY 12 巻頁： 1075 - 1079 2019年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Diabetes Metabolic Syndrome and Obesity

Objective: An association between smoking and nonalcoholic fatty liver disease has been reported. However, objective quantification of intrahepatic fat via magnetic resonance spectroscopy (MRS) in relation to smoking has rarely been performed in previous studies. Moreover, the possible pathways via which smoking could induce ectopic fat accumulation have not yet been addressed. The current study aimed to examine the association between smoking status and intrahepatic fat quantity and explore the possible mediating effects of triglycerides (TG) and adiponectin. Subjects and methods: Magnetic resonance imager (MRI) spectra were analyzed to quantify intrahepatic fat in 45 men who were on average 62.3 years of age. Smoking status and alcohol intake were self-reported. Accelerometers were used to record daily total physical activity. Fasting blood TG and adiponectin levels were measured enzymatically. Differences in mean intrahepatic fat values according to smoking status were assessed using analysis of covariance. Results: A stepwise increase in mean intrahepatic fat was observed between never, former, and current smokers, respectively, independent of age, physical activity, alcohol intake, and body mass index (BMI) (P=0.005). Adjustment for TG and adiponectin significantly attenuated this association (P=0.074). Conclusion: Current smoking was significantly associated with increased intrahepatic fat, which may be a result of adipocyte dysfunction, manifested as high circulating TG concentrations and low adiponectin levels.

DOI： 10.2147/DMSO.S212495

Self-Reported Eczema in Relation with Mortality from Cardiovascular Disease in Japanese: the Japan Collaborative Cohort Study 査読有り Open Access

Nishida, Y; Kubota, Y; Iso, H; Tamakoshi, A; Tamakoshi, A; Mori, M; Kaneko, Y; Tsuji, I; Nakamura, Y; Iso, H; Yamagishi, K; Mikami, H; Kurosawa, M; Hoshiyama, Y; Tanabe, N; Tamakoshi, K; Wakai, K; Ando, M; Suzuki, K; Hashimoto, S; Yatsuya, H; Kikuchi, S; Wada, Y; Kawamura, T; Watanabe, Y; Ozasa, K; Mikami, K; Date, C; Sakata, K; Kurozawa, Y; Fujino, Y; Shibata, A

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 26 巻 ( 9 ) 頁： 775 - 782 2019年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Atherosclerosis and Thrombosis

Aim: Previous studies suggested a positive association between eczema and cardiovascular disease (CVD), probably through enhanced systemic inflammation. However, several studies reported null findings about eczema and CVD, so the evidence is still controversial. Methods: We asked 85,099 participants (35,489 men and 49,610 women), aged 40 to 79 years, without a history of CVD or cancer at baseline between 1988 and 1990, to complete a lifestyle questionnaire, including information eczema frequency (seldom, sometimes or often). Results: During the 6,389,818 person-years of follow-up, there were 1,174 deaths from coronary heart disease (CHD), 979 from heart failure, 366 from cardiac arrhythmia, 2,454 from total stroke, 1,357 from ischemic stroke, 1,013 from hemorrhagic stroke, and 201 from aortic aneurysm or dissection. The multivariable-adjusted model showed that individuals who “sometimes” or “often” had eczema had 0.82 (95%confidence interval (CI): 0.69–0.97) or 1.26 (95%CI: 1.01–1.56) times the risk of mortality from CHD, respectively, compared to those who “seldom” did. Individuals who “often” had 1.30 (95%CI: 1.05–1.61) times the risk of mortality from CHD, compared to those who “seldom or sometimes” did. There was no association of eczema with mortality from other CVD, or no interaction between eczema and sex or age, in relation to any CVD mortality risk. Conclusions: Self-reported frequent eczema was associated with increased risk of mortality from CHD, but not other major CVD, in a Japanese general population. Since steroid usage was not considered, future studies should include it as a potential confounding factor.

DOI： 10.5551/jat.46383

Smoking results in accumulation of ectopic fat in the liver. 査読有り

Smoking results in accumulation of, ectopic fat in, the, liver, Kato A, Li Y, Ota A, Naito H, Yamada H, Nihashi T, Hotta Y, Chiang C, Hirakawa Y, Aoyama A, Tamakoshi K, Yatsuya H

Diabetes Metab Syndr Obes 9 巻 ( 12 ) 頁： 1075 - 1080 2019年

Multicenter feasibility study of bowel preparation with castor oil for colon capsule endoscopy 査読有り国際誌

Ohmiya N., Hotta N., Mitsufuji S., Nakamura M., Omori T., Maeda K., Okuda K., Yatsuya H., Tajiri H.

Gastroenterological Endoscopy 61 巻 ( 12 ) 頁： 2646 - 2655 2019年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Gastroenterological Endoscopy

Background and Aim: Extensive use of laxatives and incomplete excretion rates are problematic for colon capsule endoscopy (CCE). The aim of the present study was to determine the effectiveness of castor oil as a booster. Methods: At four Japanese hospitals, 319 examinees undergoing CCE were enrolled retrospectively. Before and after the introduction of castor oil, other preparation reagents were unchanged. Results: Of 319 examinees who underwent CCE, 152 and 167 examinees took regimens with castor oil (between November 2013 and June 2016) and without castor oil (between October 2015 and September 2017), respectively. Capsule excretion rates within its battery life in the groups with and without castor oil were 97% and 81%, respectively (P＜0.0001). Multivariate analysis showed that ages younger than 65 years (adjusted odds ratio [OR], 3.00; P=0.0048), male gender (adjusted OR, 3.20; P=0.0051), and use of castor oil (adjusted OR, 6.29; P=0.0003) were predictors of capsule excretion within its battery life. Small bowel transit time was shorter and total volume of lavage and fluid intake was lower with castor oil than without (P = 0.0154 and 0.0013, respectively). Overall adequate cleansing level ratios with and without castor oil were 74% and 83%, respectively (P = 0.0713). Per-examinee sensitivity for polyps ≥ 6 mm with and without castor oil was 83% and 85%, respectively, with specificities of 80% and 78%, respectively. Conclusion: Bowel preparation with castor oil was effective for improving capsule excretion rate and reducing liquid loading.

DOI： 10.11280/gee.61.2646

Clinical course of human herpesvirus 6 infection in pediatric living donor liver transplantation 査読有り国際誌 Open Access

Yasui, T; Suzuki, T; Yoshikawa, T; Yatsuya, H; Kawamura, Y; Miura, H; Hara, F; Watanabe, S; Uga, N; Naoe, A

PEDIATRIC TRANSPLANTATION 22 巻 ( 7 ) 頁： e13239 2018年11月

Perception and practice of 'healthy' diet in relation to noncommunicable diseases among the urban and rural people in northern Ethiopia: a community-based qualitative study 国際共著 Open Access

Gebremariam, LW; Aoyama, A; Kahsay, AB; Hirakawa, Y; Chiang, CF; Yatsuya, H; Matsuyama, A

NAGOYA JOURNAL OF MEDICAL SCIENCE 80 巻 ( 4 ) 頁： 451 - 464 2018年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nagoya Journal of Medical Science

Dietary habits are related to the risks of noncommunicable diseases (NCDs), such as cardiovascular disease and diabetes, of which burdens are increasing in low-income countries including Ethiopia. Although several epidemiological studies of NCD risk factors were conducted in Ethiopia, qualitative studies on people's dietary habit in relation to NCDs have not been conducted yet. This study aims to describe people's perception and practice of 'healthy' diet, and barriers to practice 'healthy' diet, paying attention to the dynamics between the perception and practice. We conducted 16 key informant interviews and eight focus group discussions in an urban and a rural areas in northern Ethiopia between November 2014 and January 2016. Audio-records in local language were transcribed word-for-word, and translated into English. English text data were analyzed qualitatively, through constant comparative analysis following the principles of the grounded theory. Three themes have emerged: (1) dietary habit perceived as 'good' or 'bad' for health; (2) reasons for continuing current 'unhealthy' dietary habit; and (3) current dietary habit perceived as 'traditional.' People's practice was mostly consistent with their perception, while they sometimes practiced contrary to the perception because of personal preference and physical or financial obstacles. People were often indifferent of health implications of their habitual dietary practice, such as drinking a lot of sweet coffee. We showed dynamics between perception and practice of 'healthy' diet among people in northern Ethiopia. It is needed to increase awareness of NCDs both among the urban and rural people and to improve the social environment for removing the obstacles.

DOI： 10.18999/nagjms.80.4.451

Perceptions and behavior related to noncommunicable diseases among slum dwellers in a rapidly urbanizing city, Dhaka, Bangladesh: a qualitative study 国際共著 Open Access

Al-Shoaibi, AAA; Matsuyama, A; Khalequzzaman, M; Haseen, F; Choudhury, SR; Hoque, BA; Chiang, CF; Hirakawa, Y; Yatsuya, H; Aoyama, A

NAGOYA JOURNAL OF MEDICAL SCIENCE 80 巻 ( 4 ) 頁： 559 - 569 2018年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nagoya Journal of Medical Science

The increasing burden of noncommunicable diseases (NCDs) in Bangladesh can be attributable to rapid urbanization and coinciding changes in lifestyle accompanied by nutrition transition. The objective of this study is to explore respondents' lived experiences and perceptions relating to NCDs and nutrition change in an urban slum community in Dhaka. Qualitative methods were employed to explore a general understanding of behavior related to NCDs among residents of the slum community. We conducted key informant interviews of six men and seven women of various backgrounds and five focus group discussions to focus salient topics emerged from the interviews. The transcriptions of the audio-recordings were thematically analyzed, using the constant comparison method. Four major themes emerged: (1) financial hardship influencing health; (2) urbanized lifestyle affecting diet; (3) tobacco and sweetened tea as cornerstones of social life; and (4) health-seeking behavior utilizing local resources. One notable finding was that even with general economic improvement, respondents perceived poverty to be one of the major causes of NCDs. A promising finding for potentially curbing NCDs was the current trend for women to walk for exercise contrary to the commonly held notion that urban dwellers generally lead sedentary lifestyles. This study described how urban slum dwellers in Dhaka, experiencing a transition from a traditional to urbanized lifestyle, perceived their daily practices in relation to NCDs and nutrition. Our research revealed both adverse and encouraging elements of perceptions and behavior related to NCDs, which may contribute to the optimal design of NCD prevention and health promotion programs.

DOI： 10.18999/nagjms.80.4.559

HYPERTENSION DETECTION, TREATMENT AND CONTROL RATES IN URBAN SLUM POPULATION IN BANGLADESH 査読有り国際共著

Choudhury, S; Al-Shoaibi, AAA; Khalequzzaman, M; Al Mamun, MA; Chiang, CF; Yatsuya, H; Aoyama, A

JOURNAL OF HYPERTENSION 36 巻頁： E337 - E338 2018年10月

Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study 査読有り国際誌

Kokubo, Y; Saito, I; Iso, H; Yamagishi, K; Yatsuya, H; Ishihara, J; Maruyama, K; Inoue, M; Sawada, N; Tsugane, S

CLINICAL NUTRITION 37 巻 ( 5 ) 頁： 1602 - 1608 2018年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Clinical Nutrition

Background & aims: The associations between dietary magnesium intake and stroke and coronary heart disease (CHD) incidences are inconsistent and not established in Asian. We aimed to determine the association between dietary magnesium intake and the risk of stroke and CHD in a Japanese population. Subjects/Methods: We studied 85,293 Japanese subjects by questionnaire at baseline (age 45–74 years, without cardiovascular disease or cancer in 1995 and 1998 for Cohorts I and II, respectively). The participants were followed until the end of 2009 and 2010 in Cohorts I and II, respectively. Dietary magnesium intake was estimated from a self-administered 138-item food-frequency questionnaire. Results: After 1,305,738 person-years of follow-up, 4110 strokes and 1283 cases of CHD were documented. The multivariable-adjusted hazard ratios (HRs, 95% confidence intervals, 95%CIs) of CHD for the fourth and fifth quintiles of dietary magnesium intake were 0.70 (0.50–0.99) and 0.66 (0.44–0.97) in men (P for trend = 0.036), respectively, and third quintile of dietary magnesium intake was 0.61 (0.39–0.96) in women (P for trend = 0.241), compared with the lowest quintile in men and women. We observed no decreased risks of incident stroke in men or women with higher dietary magnesium intakes. Conclusions: Higher dietary magnesium intake was associated with a reduced risk of CHD in Japanese men.

DOI： 10.1016/j.clnu.2017.08.006

γGTPとALT追加による10年間の2型糖尿病発症リスク予測能の改善愛知職域コホート査読有り

金子佳世, 八谷寛, 李媛英, 上村真由, 江啓発, 平川仁尚, 太田充彦, 玉腰浩司, 豊嶋英明, 青山温子

日本公衆衛生学会総会抄録集 77回巻頁： 204 - 204 2018年10月

食品摂取の多様性と尿中Na,K排泄量、血圧との関連 NIPPON DATA2010

大塚礼, 八谷寛, 西信雄, 奥田奈賀子, 門田文, 由田克士, 大久保孝義, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

日本公衆衛生学会総会抄録集 77回巻頁： 322 - 322 2018年10月

The association between objective measures of residence and worksite neighborhood environment, and self-reported leisure-time physical activities: The Aichi Workers' Cohort Study. 査読有り国際誌

Li Y, Yatsuya H, Hanibuchi T, Hirakawa Y, Ota A, Uemura M, Chiang C, Otsuka R, Murata C, Tamakoshi K, Toyoshima H, Aoyama A

Preventive medicine reports 11 巻頁： 282 - 289 2018年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Preventive Medicine Reports

The possible effects of a neighborhood's built environment on physical activity have not been studied in Asian countries as much as in Western countries. The present study cross-sectionally examined the relationship between geographic information system (GIS) measured residence and worksite neighborhood walkability, and the number of parks/green spaces and sports facilities within a 1 km radius of home and workplace, with self-reported leisure-time habitual (3–4 times per week or more) walking and moderate-to-vigorous intensity habitual exercise among local government workers aged 18 to 64 years living in an urban-suburban area of Aichi, Japan in 2013. A single-level binomial regression model was used to estimate the multivariable odds ratios (ORs) and 95% confidence intervals (95% CIs). Of the 1959 male and 884 female participants, 288 (15%) and 141 (16%) reported habitual walking, respectively, and 18% and 17% reported habitual exercise, respectively. Compared with women who resided in neighborhood with a walkability index of 4–30, those living in an area with that of 35–40 were significantly more likely to engage in leisure-time habitual exercise (multivariable OR: 1.70, 95% CI: 1.08–2.68). Marginally significant positive associations were found between leisure-time habitual exercise and the residential neighborhood's number of parks/green spaces among women, as well as the number of sports facilities among men. In conclusion, a residential neighborhood environment characterized by higher walkability may contribute to the initiation or maintenance of moderate-to-vigorous intensity leisure-time exercise among working women living in an urban-suburban area of Japan.

DOI： 10.1016/j.pmedr.2018.07.007

Pooled analysis of the associations between body mass index, total cholesterol, and liver cancer-related mortality in Japan 査読有り

Ukawa S, Tamakoshi A, Murakami Y, Kiyohara Y, Yamada M, Nagai M, Satoh A, Miura K, Ueshima H, Okamura T, Imai Y, Ohkubo T, Irie F, Iso H, Kitamura A, Ninomiya T, Nakagawa H, Nakayama T, Okayama A, Sairenchi T, Saitoh S, Sakata K, Tsuji I, Kiyama M, Miyamoto Y, Ishikawa S, Yatsuya H

Asian Pacific Journal of Cancer Prevention 19 巻 ( 8 ) 頁： 2089 - 2095 2018年8月

記述言語：英語出版者・発行元：Asian Pacific Journal of Cancer Prevention

© 2018 Asian Pacific Organization for Cancer Prevention. Objective: We employed a large-scale pooled analysis to investigate the association of liver cancer-related mortality with being overweight/obese and total cholesterol (TC) levels, since limited and inconsistent data on these associations exist in Japan. Methods: A total of 59,332 participants (23,853 men and 35,479 women) from 12 cohorts without a history of cancer who were followed for a median of 14.3 years were analyzed. A sex-specific stratified Cox proportional hazards model adjusted for age and other potential confounders was used to calculate hazard ratios (HRs) and 95% confidence intervals (CI) for liver cancer-related mortality. Results: A total of 447 participants (266 men and 181 women) died of liver cancer within the follow-up period. Individuals classified as having a high BMI (≥25.0 kg/m2) and low TC levels (< 160 mg/dL) had a significantly increased risk for liver cancer-related mortality (HR 7.05, 95% CI 4.41-11.26 in men; HR 8.07, 95% CI 4.76-13.67 in women) when compared with those in the intermediate BMI (18.5-24.9 kg/m2) and TC (160-219 mg/dL) categories. These associations remained after limiting the

DOI： 10.22034/APJCP.2018.19.8.2089

Association of extremely high levels of high-density lipoprotein cholesterol with cardiovascular mortality in a pooled analysis of 9 cohort studies including 43,407 individuals: The EPOCH–JAPAN study

Late-phase human herpesvirus 6B reactivation in hematopoietic stem cell transplant recipients 査読有り国際誌

Miura, H; Kawamura, Y; Hattori, F; Tanaka, M; Kudo, K; Ihira, M; Yatsuya, H; Takahashi, Y; Kojima, S; Yoshikawa, T

TRANSPLANT INFECTIOUS DISEASE 20 巻 ( 4 ) 頁： e12916 2018年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Transplant Infectious Disease

Background: We sought to determine whether late-phase human herpesvirus 6B (HHV-6B) infection in hematopoietic stem cell transplant (HSCT) recipients was associated with serious outcomes and mortality. Methods: The occurrence and course of HHV-6B infection was monitored for at least 60 days after transplant using virus isolation and real-time polymerase chain reaction. Risk factors for late-phase HHV-6B infection were examined, and the propensity score was calculated with significant risk factors. The inverse probability-weighted multivariable logistic regression analysis was performed to estimate odds ratios (ORs) and the 95% confidence intervals (95% CI) for mortality. Results: Late-phase HHV-6B infection was observed in 12/89 (13.5%) of the HSCT recipients. Older age (OR: 10.3, 95% CI: 2.1/72.9, P =.0027), hematologic malignancy (OR: 10.3, 95% CI: 1.8/97.1, P =.0063), unrelated donor transplantation (OR: 5.3, 95% CI: 1.1/36.0, P =.0345), and sex-mismatched donor transplantation (OR: 6.3, 95% CI: 1.4/39.5, P =.0149) were identified as risk factors for late-phase HHV-6B infection. Fifteen subjects died (17%). Inverse probability-weighted multivariable logistic model analysis revealed that late-phase HHV-6B infection was an independent risk factor for mortality (OR: 4.2, 95% CI: 1.7/11.0, P =.0012). Among 5 of the fatal cases of late-phase HHV-6B infection, viral infection might be associated with severe clinical manifestations. Conclusion: Late-phase HHV-6B infection in HSCT recipients was associated with worse outcomes. The full spectrum of clinical features of the infection has not been fully elucidated, and therefore, recipients with high-risk factors for late-phase HHV-6B infection should be carefully monitored.

DOI： 10.1111/tid.12916

Cardiovascular disease mortality in relation to physical activity during adolescence and adulthood in Japan: Does school-based sport club participation matter? 査読有り国際共著国際誌 Open Access

Gero, K; Iso, H; Kitamura, A; Yamagishi, K; Yatsuya, H; Tamakoshi, A

PREVENTIVE MEDICINE 113 巻頁： 102 - 108 2018年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ACADEMIC PRESS INC ELSEVIER SCIENCE

We examined potential associations of sport club participation during adolescence and sports-related physical activity during adulthood with mortality from cardiovascular diseases (CVD) in a Japanese population. Between 1988 and 1990, 29,526 men and 41,043 women aged 40-79 years responded to a questionnaire including questions about the frequency of sports participation at baseline and sport club participation during junior/senior high school. Subjects were followed-up until the end of 2009, and 4230 cardiovascular deaths (870 CHD, 1859 stroke) were identified. Cox proportional-hazard regression models were used to estimate hazard ratios (HR). During the first-two thirds of the follow-up - where the proportional hazards assumption was met - the multivariate-adjusted HR (95% confidence interval) for total CVD mortality was 0.77 (0.61-0.98) among men and 0.82 (0.61-1.10) among women who were physically active at baseline (≥5 h/week versus 1-2 h/week). The corresponding HRs for coronary heart disease (CHD) mortality were 0.65 (0.39-1.07) and 0.40 (0.17-0.91), respectively. The combined associations of sports participation during adulthood and adolescence were also examined. Am

DOI： 10.1016/j.ypmed.2018.05.012

Effect of laughter yoga on salivary cortisol and dehydroepiandrosterone among healthy university students: A randomized controlled trial 査読有り国際誌

Fujisawa, A; Ota, A; Matsunaga, M; Li, YY; Kakizaki, M; Naito, H; Yatsuya, H

COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE 32 巻頁： 6 - 11 2018年8月

Non-communicable disease risk factor profile among public employees in a regional city in northern Ethiopia 査読有り国際共著国際誌 Open Access

Gebremariam, LW; Chiang, C; Yatsuya, H; Hilawe, EH; Kahsay, AB; Godefays, H; Abraham, L; Hirakawa, Y; Iso, H; Aoyama, A

SCIENTIFIC REPORTS 8 巻 ( 1 ) 頁： 9298 2018年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

The burden of non-communicable diseases (NCDs) is increasing in Ethiopia. This study aims to describe the prevalence of NCD risk factors of public employees in a regional city in northern Ethiopia. We conducted a cross-sectional epidemiological study targeting men and women aged 25-64 years employed by public offices in Mekelle. The prevalence was age-standardized to the Ethiopian 2007 population. Among the 1380 subjects (823 men and 557 women), 68.7% had less than 1 serving of fruits and vegetables per day, 41.0% were physically inactive, and 57.3% observed religious fast. The age-standardised prevalence of abdominal obesity was 29.3% in men and 58.5% in women, but that of metabolic syndrome was comparable between men (39.2%) and women (39.0%). The prevalence of diabetes was underestimated if only fasting blood glucose (FBG) was used for the diagnosis compared to combination of FBG and glycated haemoglobin (HbA1c) (6.7% in men and 3.8% in women vs. 12.1% in men and 5.6% in women). More than a quarter (26.1%) of men and 8.7% of women had estimated 10-year risk of cardiovascular disease of 10% or more. This study revealed the high prevalence of NCD metabolic risk factors among the urban public employees in the highland of Ethiopia.

DOI： 10.1038/s41598-018-27519-6

Hirata A, Sugiyama D, Watanabe M, Tamakoshi A, Iso H, Kotani K, Kiyama M, Yamada M, Ishikawa S, Murakami Y, Miura K, Ueshima H, Okamura T, Okamura T, Imai Y, Ohkubo T, Irie F, Iso H, Kitamura A, Ninomiya T, Kiyohara Y, Miura K, Murakami Y, Nakagawa H, Nakayama T, Okayama A, Sairenchi T, Saitoh S, Sakata K, Tamakoshi A, Tsuji I, Yamada M, Miyamoto Y, Ishikawa S, Yatsuya H

Journal of Clinical Lipidology 12 巻 ( 3 ) 頁： 674 - 684.e5 2018年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Clinical Lipidology

© 2018 National Lipid Association Background: The effect of very high or extremely high levels of high-density lipoprotein cholesterol (HDL-C) on cardiovascular disease (CVD) is not well described. Although a few recent studies have reported the adverse effects of extremely high levels of HDL-C on CVD events, these did not show a statistically significant association between extremely high levels of HDL-C and cause-specific CVD mortality. In addition, Asian populations have not been studied. Objective: We examine the impact of extremely high levels of HDL-C on cause-specific CVD mortality using pooled data of Japanese cohort studies. Methods: We performed a large-scale pooled analysis of 9 Japanese cohorts including 43,407 participants aged 40–89 years, dividing the participants into 5 groups by HDL-C levels, including extremely high levels of HDL-C ≥2.33 mmol/L (≥90 mg/dL). We estimated the adjusted hazard ratio of each HDL-C category for all-cause death and cause-specific deaths compared with HDL-C 1.04–1.55 mmol/L (40–59 mg/dL) using a cohort-stratified Cox proportional hazards model. Results: During a 12.1-year follow-up, 4995 all-cause deaths and 1280 deaths due to

DOI： 10.1016/j.jacl.2018.01.014

降圧剤の投与は高血圧ラット肝臓Cyp7a1プロモーターのメチル化頻度を低下させる

内藤久雄, 三宅邦夫, 袁援, 橋本沙幸, 浅野友美, 北森一哉, 八谷寛, 那須民江

産業衛生学雑誌 60 巻 ( 臨増 ) 頁： 303 - 303 2018年5月

Association between average daily television viewing time and the incidence of ovarian cancer: findings from the Japan Collaborative Cohort Study 査読有り国際誌

Ukawa, S; Tamakoshi, A; Mori, M; Ikehara, S; Shirakawa, T; Yatsuya, H; Iso, H

CANCER CAUSES & CONTROL 29 巻 ( 2 ) 頁： 213 - 219 2018年2月

Relationships among Socioeconomic Factors and Self-rated Health in Japanese Adults: NIPPON DATA2010 査読有り Open Access

Ota, A; Yatsuya, H; Nishi, N; Okuda, N; Ohkubo, T; Hayakawa, T; Kadota, A; Okayama, A; Miura, K

JOURNAL OF EPIDEMIOLOGY 28 巻 ( Supplement_III ) 頁： S66 - S72 2018年

A Point System for Predicting 10-Year Risk of Developing Type 2 Diabetes Mellitus in Japanese Men: Aichi Workers' Cohort Study 査読有り Open Access

Yatsuya Hiroshi, Li Yuanying, Hirakawa Yoshihisa, Ota Atsuhiko, Matsunaga Masaaki, Haregot Hilawe Esayas, Chiang Chifa, Zhang Yan, Tamakoshi Koji, Toyoshima Hideaki, Aoyama Atsuko

JOURNAL OF EPIDEMIOLOGY 28 巻 ( 8 ) 頁： 347 - 352 2018年

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: Relatively little evidence exists for type 2 diabetes mellitus (T2DM) prediction models from long-term follow-up studies in East Asians. This study aims to develop a point-based prediction model for 10-year risk of developing T2DM in middle-aged Japanese men. Methods: We followed 3,540 male participants of Aichi Workers’ Cohort Study, who were aged 35–64 years and were free of diabetes in 2002, until March 31, 2015. Baseline age, body mass index (BMI), smoking status, alcohol consumption, regular exercise, medication for dyslipidemia, diabetes family history, and blood levels of triglycerides (TG), high density lipoprotein cholesterol (HDLC) and fasting blood glucose (FBG) were examined using Cox proportional hazard model. Variables significantly associated with T2DM in univariable models were simultaneously entered in a multivariable model for determination of the final model using backward variable selection. Performance of an existing T2DM model when applied to the current dataset was compared to that obtained in the present study’s model. Results: During the median follow-up of 12.2 years, 342 incident T2DM cases were documented. The prediction system using points assigned to age, BMI, smoking status, diabetes family history, and TG and FBG showed reasonable discrimination (c-index: 0.77) and goodness-of-fit (Hosmer-Lemeshow test, P = 0.22). The present model outperformed the previous one in the present subjects. Conclusion: The point system, once validated in the other populations, could be applied to middle-aged Japanese male workers to identify those at high risk of developing T2DM. In addition, further investigation is also required to examine whether the use of this system will reduce incidence.

DOI： 10.2188/jea.JE20170048

[Study on the probability of incident stroke and acute myocardial infarction using DPC data]. 査読有り Open Access

Kakizaki M, Sawada N, Yamagishi K, Yatsuya H, Saito I, Kokubo Y, Iso H, Tsugane S, Yasunaga H

[Nihon koshu eisei zasshi] Japanese journal of public health 65 巻 ( 4 ) 頁： 179 - 186 2018年

肥満と動脈硬化

八谷寛, 李媛英, 金子佳世, 太田充彦

食と医療 4 巻頁： 72 - 79 2018年

Prevalence of non-communicable disease risk factors among poor shantytown residents in Dhaka, Bangladesh: a community-based cross-sectional survey 査読有り国際共著国際誌 Open Access

Khalequzzaman, M; Chiang, C; Choudhury, SR; Yatsuya, H; Al-Mamun, MA; Al-Shoaibi, AAA; Hirakawa, Y; Hoque, BA; Islam, SS; Matsuyama, A; Iso, H; Aoyama, A

BMJ OPEN 7 巻 ( 11 ) 頁： e014710 2017年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMJ Open

Objectives This study aims to describe the prevalence of non-communicable disease (NCD) risk factors among the urban poor in Bangladesh. Design We conducted a community-based cross-sectional epidemiological study. Setting The study was conducted in a shantytown in the city of Dhaka. There were 8604 households with 34 170 residents in the community. Those households were categorised into two wealth strata based on the housing structure. Participants The study targeted residents aged 18-64 years. A total of 2986 eligible households with one eligible individual were selected by simple random sampling stratified by household wealth status. A total of 2551 residents completed the questionnaire survey, and 2009 participated in the subsequent physical and biochemical measurements. Outcome measures A modified WHO survey instrument was used for assessing behavioural risk factors and physical and biochemical measurements, including glycated haemoglobin (HbA1c). The prevalence of NCD risk factors, such as tobacco use, fruit and vegetable intake, overweight/obesity, hypertension, diabetes (HbA1c ≥6.5%) and dyslipidaemia, was described according to household wealth status and gender differences. Results The prevalence of current tobacco use was 60.4% in men and 23.5% in women. Most of them (90.8%) consumed more than 1 serving of fruits and vegetables per day; however, only 2.1% consumed more than 5 servings. Overweight/obesity was more common in women (39.2%) than in men (18.9%), while underweight was more common in men (21.0%) than in women (7.1%). The prevalence of hypertension was 18.6% in men and 20.7% in women. The prevalence of diabetes was 15.6% in men and 22.5% in women, which was much higher than the estimated national prevalence (7%). The prevalence of raised total cholesterol (≥190 mg/dL) was 25.7% in men and 34.0% in women. Conclusion The study identified that tobacco use, both overweight and underweight, diabetes, hypertension and dyslipidaemia were prevalent among the urban poor in Bangladesh.

DOI： 10.1136/bmjopen-2016-014710

Alcohol consumption and mortality from aortic disease among Japanese men: The Japan Collaborative Cohort study 査読有り国際誌 Open Access

Shirakawa, T; Yamagishi, K; Yatsuya, H; Tanabe, N; Tamakoshi, A; Iso, H

ATHEROSCLEROSIS 266 巻頁： 64 - 68 2017年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Atherosclerosis

Background and aims Only a few population-based prospective studies have examined the association between alcohol consumption and abdominal aortic aneurysm, and the results are inconsistent. Moreover, no evidence exists for aortic dissection. We examined the effect of alcohol consumption on risk of mortality from aortic diseases. Methods A total of 34,720 men from the Japan Collaborative Cohort study, aged 40–79 years, without history of cardiovascular disease and cancer at baseline 1988 and 1990 were followed up until the end of 2009 for their mortality and its underlying cause. Hazard ratios of mortality from aortic diseases were estimated according to alcohol consumption categories of never-drinkers, ex-drinkers, regular drinkers of ≤30 g, and >30 g ethanol per day. Results During the median 17.9-year follow-up period, 45 men died of aortic dissection and 41 men died of abdominal aortic aneurysm. Light to moderate drinkers of ≤30 g ethanol per day had lower risk of mortality from total aortic disease and aortic dissection compared to never-drinkers. The respective multivariable hazard ratios (95% confidence intervals) were 0.46 (0.28–0.76) for total aortic disease and 0.16 (0.05–0.50) for aortic dissection. Heavy drinkers of >30 g ethanol per day did not have reduced risk of mortality from total aortic disease, albeit had risk variation between aortic dissection and abdominal aortic aneurysm. Conclusions Light to moderate alcohol consumption was associated with reduced mortality from aortic disease among Japanese men.

DOI： 10.1016/j.atherosclerosis.2017.08.025

Association of high-density lipoprotein cholesterol concentration with different types of stroke and coronary heart disease: The Japan Public Health Center-based prospective (JPHC) study 査読有り国際誌

Saito, I; Yamagishi, K; Kokubo, Y; Yatsuya, H; Iso, H; Sawada, N; Inoue, M; Tsugane, S

ATHEROSCLEROSIS 265 巻頁： 147 - 154 2017年10月

Functional capacity, self-rated health status, and psychosocial characteristics of employed cancer survivors in Japan 査読有り国際誌

Katoh Y, Ota A, Yatsuya H, Li Y, Naito H, Fujisawa A, Matsunaga M, Hirakawa Y, Chiang C, Toyoshima H, Tamakoshi K, Aoyama A

Fujita Medical Journal 3 巻 ( 3 ) 頁： 55 - 61 2017年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：藤田医科大学医学会

Objectives: This study investigated restrictions in functional capacity, self-rated health status (SRHS), and psychosocial characteristics of employed cancer survivors in Japan and examined differences in these characteristics between cancer survivors and employees without cancer history.Methods: A cross-sectional survey was carried out. Subjects were local government employees in Japan in 2013 (n=5,474). Using a self-administered questionnaire, we evaluated restrictions in functional capacity, SRHS, and the following psychosocial characteristics: social support, perceived stress, social capital, positive reasons for living (ikigai), and happiness. We examined whether cancer history was associated with restrictions in functional capacity, SRHS, and psychosocial characteristics.Results: A total of 112 employees were cancer survivors. Of these, males of all ages and comparatively younger females had restrictions in functional capacity more frequently than the corresponding subjects without cancer history (males of all ages: 14.5% vs. 2.9%, p<0.001; females <50 years: 15.2% vs. 1.1%, p<0.001). Among males of all ages, cancer survivors reported bad SRHS more frequently than employees without cancer history (8.1% vs. 1.5%, p=0.003). No significant differences were found in psychosocial characteristics by cancer history.Conclusions: Male and comparatively young female employed cancer survivors frequently experienced restrictions in functional capacity. Male employed cancer survivors self-rated their health status as bad more frequently than male employees without cancer history.

DOI： 10.20407/fmj.3.3_55

A pooled analysis of the association of isolated low levels of high-density lipoprotein cholesterol with cardiovascular mortality in Japan 査読有り

Takumi Hirata, Daisuke Sugiyama, Shin-ya Nagasawa, Yoshitaka Murakami, Shigeyuki Saitoh, Akira Okayama, Hiroyasu Iso, Fujiko Irie, Toshimi Sairenchi, Yoshihiro Miyamoto, Michiko Yamada, Shizukiyo Ishikawa, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura, for the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) Research Group, Hirotsugu Ueshima, Tomonori Okamura, Yutaka Imai, Takayoshi Ohkubo, Fujiko Irie, Hiroyasu Iso, Akihiko Kitamura, Yutaka Kiyohara, Katsuyuki Miura, Yoshitaka Murakami, Hideaki Nakagawa, Takeo Nakayama, Akira Okayama, Toshimi Sairenchi, Shigeyuki Saitoh, Kiyomi Sakata, Akiko Tamakoshi, Ichiro Tsuji, Michiko Yamada, Masahiko Kiyama, Yoshihiro Miyamoto, Shizukiyo Ishikawa, Hiroshi Yatsuya, Tomonori Okamura

European Journal of Epidemiology 32 巻 ( 7 ) 頁： 547 - 557 2017年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Netherlands

Low levels of serum high-density lipoprotein cholesterol (HDL-C) have been shown to be associated with increased risk of coronary heart disease (CHD). However, because this is usually observed in the context of other lipid abnormalities, it is not known whether isolated low serum HDL-C levels are an independent risk factor for CHD. We performed a large pooled analysis in Japan using data from nine cohorts with 41,206 participants aged 40–89 years who were free of cardiovascular disease at baseline. We divided participants into three groups: isolated low HDL-C, non-isolated low HDL-C, and normal HDL-C. Cohort-stratified Cox proportional hazards models were used to estimate multivariate-adjusted hazard ratios (HRs) for death due to CHD, ischemic stroke, and intracranial cerebral hemorrhage
during a 12.9-year follow-up, we observed 355, 286, and 138 deaths, respectively, in these groups. Non-isolated low HDL-C was significantly associated with increased risk of CHD compared with normal HDL-C (HR 1.37, 95 % confidence interval (CI) 1.04–1.80)
however, isolated low HDL-C was not. Although isolated low HDL-C was significantly associated with decreased risk of CHD (HR 0.51, 95 % CI 0.29–0.89) in women, it was significantly associated with increased risk of intracranial cerebral hemorrhage in all participants (HR 1.62, 95 % CI 1.04–2.53) and in men (HR 2.00, 95 % CI 1.04–3.83). In conclusion, isolated low HDL-C levels are not associated with increased risk of CHD in Japan. CHD risk may, therefore, be more strongly affected by serum total cholesterol levels in this population.

DOI： 10.1007/s10654-016-0203-1

A Point-based Prediction Model for Predicting 10-year Risk of Developing Type 2 Diabetes Mellitus in Japanese Men: Aichi Workers' Cohort Study 査読有り

Synergistic and Non-synergistic Associations for Cigarette Smoking and Non-tobacco Risk Factors for Cardiovascular Disease Incidence in the Atherosclerosis Risk In Communities (ARIC) Study 査読有り国際共著国際誌 Open Access

Lubin, JH; Couper, D; Lutsey, PL; Yatsuya, H

NICOTINE & TOBACCO RESEARCH 19 巻 ( 7 ) 頁： 826 - 835 2017年7月

Matsunaga, M; Yatsuya, H; Iso, H; Yamashita, K; Li, YY; Yamagishi, K; Tanabe, N; Wada, Y; Wang, CC; Ota, A; Tamakoshi, K; Tamakoshi, A

ATHEROSCLEROSIS 261 巻頁： 124 - 130 2017年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Atherosclerosis

Background and aims Coronary heart disease (CHD) and stroke have common risk factors, but some of these differ in the magnitude or direction of associations between CHD and stroke. We assessed whether the impact of each risk factor differed between CHD and stroke mortality in Asians. Methods In total, 104 910 subjects aged 40–79 years without histories of cancer, CHD and stroke at baseline were followed between 1988 and 2009. Competing-risks analysis was used to test for differences in the associations of each risk factor with two endpoints (CHD and stroke). Population attributable fractions (PAFs) were also calculated for these endpoints to estimate the population impact of each risk factor. Results During a median 19.1-year follow-up, 1554 died from CHD and 3163 from stroke. The association of hypertension with CHD was similar to that with stroke in terms of the magnitude and direction (multivariable-adjusted hazard ratio for CHD: 1.63 vs. stroke: 1.73 in men and 1.70 vs. 1.66 in women). Conversely, the magnitude of these associations differed for smoking (CHD: 1.95 vs. stroke: 1.23 in men and 2.45 vs. 1.35 in women) and diabetes (1.49 vs. 1.09 in men and 2.08 vs. 1.39 in women). The highest PAF for CHD was caused by smoking in men and by hypertension in women; that for stroke was caused by hypertension in both sexes. Conclusions Hypertension associations and PAFs were consistent between CHD and stroke, but not for other risk factors. These findings may be useful to optimize public health intervention strategies.

DOI： 10.1016/j.atherosclerosis.2017.03.003

Passive smoking and chronic obstructive pulmonary disease mortality: findings from the Japan collaborative cohort study 査読有り国際誌

Ukawa, S; Tamakoshi, A; Yatsuya, H; Yamagishi, K; Ando, M; Iso, H

INTERNATIONAL JOURNAL OF PUBLIC HEALTH 62 巻 ( 4 ) 頁： 489 - 494 2017年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Public Health

Objectives: To elucidate the association between passive smoking at home and chronic obstructive pulmonary disease (COPD) mortality via a large-scale nationwide cohort study in Japan. Methods: Never smokers (n = 34,604) aged 40–79 years at baseline (1988–1990; 4884 men, 29,720 women) were included in the analysis. Passive smoking at home was measured based on self-reported frequency of weekly exposure to passive smoking at home. An inverse probability of treatment-weighted competing risk model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for COPD mortality. Results: During a median follow-up of 16.4 years, 33 participants (10 men, 23 women) died of COPD. The HR for participants exposed to passive smoking at home ≤4 days per week or those who had almost daily exposure to passive smoking at home had a significantly increased risk of COPD mortality (HR 2.40, 95% CI 1.39–4.15, HR 2.88, 95% CI 1.68–4.93, respectively). Conclusions: The present findings suggest that avoiding passive smoking at home may be beneficial for preventing death due to COPD among never smokers.

DOI： 10.1007/s00038-016-0938-1

Descriptive Epidemiology of Hypertension and Its Association With Obesity: Based on the WHO STEPwise Approach to Surveillance in Palau 査読有り国際共著国際誌

Wang, CC; Chiang, CF; Yatsuya, H; Hilawe, EH; Ikerdeu, E; Honjo, K; Mita, T; Cui, RZ; Hirakawa, Y; Madraisau, S; Iso, H; Aoyama, A

ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH 29 巻 ( 4 ) 頁： 278 - 287 2017年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Asia Pacific Journal of Public Health

The rise of noncommunicable diseases is a serious health burden for Palau. This study described the prevalence of hypertension, and assessed its association with obesity. Surveys following the WHO STEPwise approach to surveillance were conducted in 2529 adults. Multivariate prevalence ratios (PR) of hypertension for body mass index (BMI) categories were calculated by logistic regression models using conditional standardization procedure. Age- and sex-specified analyses were performed. Overall prevalence of obesity and hypertension were 40.4% and 46.8%, respectively. Prevalence of hypertension was positively associated with BMI. However, overweight men had as high prevalence of hypertension as the obese (multivariable-adjusted PR was 1.84 for overweight and 1.91 for obese compared with nonoverweight). The association between hypertension and BMI was similar across age groups. The prevalence of hypertension in women increased gradually with the increase of BMI whereas that in men reached a plateau already in the overweight.

DOI： 10.1177/1010539517704042

Disparity in metabolic risk factors of non-communicable diseases between Palauans and Filipinos living in Palau 査読有り国際共著国際誌 Open Access

Osako, A; Chiang, CF; Ito, K; Yatsuya, H; Hilawe, EH; Ikerdeu, E; Honjo, K; Mita, T; Cui, RZ; Hirakawa, Y; Madraisau, S; Ngirmang, G; Iso, H; Aoyama, A

NAGOYA JOURNAL OF MEDICAL SCIENCE 79 巻 ( 2 ) 頁： 157 - 165 2017年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nagoya Journal of Medical Science

Non-communicable diseases have been recognized as a serious threat to public health in Palau. To tackle the problem, different strategies might be necessary for populations with different ethnic backgrounds. This study aims to find the differences in the prevalence of metabolic risk factors of non-communicable diseases between Palauans and Filipinos living in Palau, and examine possible determinants of the differences. We selected data of 2,032 participants, including native Palauans and Filipinos, from the Palau STEPS Survey 2011-2013 for this study. Logistic regression models were used to inspect the association of each metabolic risk factor with ethnicity by calculating odds ratios adjusted for potential confounding factors. Palauans had higher age-standardized prevalence of overweight or obesity (84% vs. 45%), hypertension (50% vs. 38%) and diabetes (19% vs. 13%) than Filipinos. However, after adjusting for BMI and various lifestyle related factors, there are no statistical significant differences in the prevalence of hypertension and diabetes between these two ethnic groups. Palauan men were less likely to have elevated total cholesterol, especially after adjusting for BMI (odds ratio=0.55, 95% confidence interval: 0.33-0.91), while Palauan women were more likely to have elevated triglycerides than their Filipino counterparts (odds ratio=1.45, 95% confidence interval: 1.02-2.06). Our findings suggested that Palauans' higher BMI distribution might be able to explain their higher prevalence of hypertension and partially explain their higher diabetes prevalence. Palauans were not consistently more likely to have all metabolic risk factors, namely dyslipidemia were less likely to be observed in Palauan men.

DOI： 10.18999/nagjms.79.2.157

Increased airway hyperresponsiveness to adenosine in patients with aspirin intolerant asthma 査読有り国際誌 Open Access

Isogai, S; Niwa, Y; Yatsuya, H; Hayashi, M; Yamamoto, N; Okamura, T; Minezawa, T; Goto, Y; Yamaguchi, T; Takeyama, T; Sakakibara, Y; Morikawa, S; Horiguchi, T; Gotoh, Y; Mieno, Y; Uozu, S; Nakanishi, T; Okazawa, M; Sakakibara, H; Imaizumi, K

ALLERGOLOGY INTERNATIONAL 66 巻 ( 2 ) 頁： 360 - 362 2017年4月

Long-term weight-change slope, weight fluctuation and risk of type 2 diabetes mellitus in middle-aged Japanese men and women: findings of Aichi Workers' Cohort Study 査読有り国際誌 Open Access

Zhang, Y; Yatsuya, H; Li, Y; Chiang, C; Hirakawa, Y; Kawazoe, N; Tamakoshi, K; Toyoshima, H; Aoyama, A

NUTRITION & DIABETES 7 巻 ( 3 ) 頁： e252 2017年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nutrition and Diabetes

OBJECTIVE: This study aims to investigate the association of long-term weight-change slopes, weight fluctuation and the risk of type 2 diabetes mellitus (T2DM) in middle-aged Japanese men and women. METHODS: A total of 4234 participants of Aichi Workers' Cohort Study who were aged 35-66 years and free of diabetes in 2002 were followed through 2014. Past body weights at the ages of 20, 25, 30, 40 years, and 5 years before baseline as well as measured body weight at baseline were regressed on the ages. Slope and root-mean-square-error of the regression line were obtained and used to represent the weight changes and the weight fluctuation, respectively. The associations of the weight-change slopes and the weight fluctuation with incident T2DM were estimated by Cox proportional hazards models. RESULTS: During the median follow-up of 12.2 years, 400 incident cases of T2DM were documented. After adjustment for baseline overweight and other lifestyle covariates, the weight-change slopes were significantly associated with higher incidence of T2DM (hazard ratio (HR): 1.80, 95% confident interval (CI): 1.17-2.77 for men; and HR: 2.78, 95% CI: 1.07-7.23 for women), while the weight fluctuation was not (HR: 1.08, 95% CI: 1.00-1.18 for men and HR: 1.02, 95% CI: 0.84-1.25 for women). CONCLUSIONS: Regardless of the presence of overweight, the long-term weight-change slopes were significantly associated with the increased risk of T2DM; however, the weight fluctuation was not associated with the risk of T2DM in middle-aged Japanese men and women.

DOI： 10.1038/nutd.2017.5

Daily Walking Time and Pneumonia Mortality Among Elderly With/Without Medical History of Myocardial Infarction or Stroke 査読有り

Ukawa Shigekazu, Zhao Wenjing, Yatsuya Hiroshi, Yamagishi Kazumasa, Iso Hiroyasu, Tamakoshi Akiko

CIRCULATION 135 巻 2017年3月

Li, YY; Yatsuya, H; Hirakawa, Y; Ota, A; Matsunaga, M; Haregot, HE; Chiang, CF; Zhang, Y; Tamakoshi, K; Toyoshima, H; Aoyama, A

CIRCULATION 135 巻 2017年3月

Daily Walking Time and Pneumonia Mortality Among Elderly With/Without Medical History of Myocardial Infarction or Stroke 査読有り

Shigekazu Ukawa, Wenjing Zhao, Hiroshi Yatsuya, Kazumasa Yamagishi, Hiroyasu Iso, Akiko Tamakoshi

CIRCULATION 135 巻 2017年3月

No modifying effect of education level on the association between lifestyle behaviors and cardiovascular mortality: the Japan Collaborative Cohort Study 査読有り国際誌 Open Access

Eguchi, E; Iso, H; Honjo, K; Yatsuya, H; Tamakoshi, A

SCIENTIFIC REPORTS 7 巻頁： 39820 2017年1月

Population profile and residential environment of an urban poor community in Dhaka, Bangladesh 査読有り国際共著国際誌 Open Access

Khalequzzaman, M; Chiang, CF; Hoque, BA; Choudhury, SR; Nizam, S; Yatsuya, H; Matsuyama, A; Hirakawa, Y; Islam, SS; Iso, H; Aoyama, A

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE 22 巻 ( 1 ) 頁： 1 2017年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Environmental Health and Preventive Medicine

Objectives: A population survey was conducted in an urban shantytown in Bangladesh, as a baseline study of future epidemiological studies. This paper aims to describe the findings of the study, including the population profile and residential environment of the urban poor. Methods: We conducted a complete count household survey in an urban poor community in Dhaka. Using a brief structured questionnaire in Bengali language, trained interviewers visited each household and asked questions such as: duration of residence; ownership of house, toilet and kitchen; water supply; number of family members; age, sex, education, occupation, tobacco use, and history of diseases of each family member. Results: We found that there were 8604 households and 34,170 people in the community. Average number of household members was 4.0. Most people had access to safe water, but only 16% lived in the house with a toilet. Based on the proxy indicators of household wealth levels, we identified that about 39% were relatively well-off, while the rest were very poor. Tobacco use was prevalent in men regardless of age and in women aged over 35 years. Prevalence of self-reported hypertension and diabetes was slightly higher in women than in men, although over 70% of the respondents didn't know if they had such diseases. Incidences of diarrhea in the last one month were relatively low. Conclusions: The study showed population profile and sanitation environment in an urban poor community by a complete count survey. We expect the study to serve as a baseline for future epidemiological studies.

DOI： 10.1186/s12199-017-0610-2

Risk Factor of Cardiovascular Disease Among Older Individuals 査読有り国際誌 Open Access

Yatsuya, H; Matsunaga, M; Li, YY; Ota, A

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 24 巻 ( 3 ) 頁： 258 - 261 2017年

Age-specific impact of diabetes mellitus on the risk of cardiovascular mortality: An overview from the evidence for Cardiovascular Prevention from Observational Cohorts in the Japan Research Group (EPOCH-JAPAN) 査読有り Open Access

Yoichiro Hirakawa, the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Research Group (EPOCH-JAPAN), Toshiharu Ninomiya, Yutaka Kiyohara, Yoshitaka Murakami, Shigeyuki Saitoh, Hideaki Nakagawa, Akira Okayama, Akiko Tamakoshi, Kiyomi Sakata, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura, Yutaka Imai, Takayoshi Ohkubo, Fujiko Irie, Hiroyasu Iso, Akihiko Kitamura, Takeo Nakayama, Toshimi Sairenchi, Ichiro Tsuji, Michiko Yamada, Masahiko Kiyama, Yoshihiro Miyamoto, Shizukiyo Ishikawa, Hiroshi Yatsuya

Journal of Epidemiology 27 巻 ( 3 ) 頁： 123 - 129 2017年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japan Epidemiology Association

Background: Diabetes mellitus is a strong risk factor for cardiovascular disease. However, the age-specific association of diabetes with cardiovascular risk, especially in the elderly, remains unclear in non-Western populations. Methods: A pooled analysis was conducted using 8 cohort studies (mean follow-up period, 10.3 years) in Japan, combining the data from 38,854 individual participants without history of cardiovascular disease. In all, 1867 of the participants had diabetes, defined based on the 1998 World Health Organization criteria. The association between diabetes and the risk of death from cardiovascular disease, coronary heart disease (CHD), and stroke was estimated using a stratified Cox model, accounting for variability of baseline hazard functions among cohorts. Results: During the follow-up, 1376 subjects died of cardiovascular disease (including 268 of coronary heart disease and 621 of stroke). Diabetes was associated with an increased risk of cardiovascular death after multivariable adjustment (hazard ratio [HR] 1.62
95% confidence interval [CI], 1.35-1.94). Similarly, diabetes was a risk factor for CHD (HR 2.13
95% CI, 1.47-3.09) and stroke (HR 1.40
95% CI, 1.05-1.85). In the age-stratified analysis of the risk of cardiovascular death, the relative effects of diabetes were consistent across age groups (p for heterogeneity = 0.18), whereas the excess absolute risks of diabetes were greater in participants in their 70s and 80s than in younger subjects. Conclusions: The management of diabetes is important to reduce the risk of death from cardiovascular disease, not only in midlife but also in late life, in the Japanese population.

DOI： 10.1016/j.je.2016.04.001

Dietary intake of saturated fatty acids and mortality from cardiovascular disease in Japanese: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) Study 査読有り

Yamagishi K, Iso H, Yatsuya H, Tanabe N, Date C, Kikuchi S, Yamamoto A, Inaba Y, Tamakoshi A; JACC Study Group.

Am J Clin Nutr 92 巻 ( 4 ) 頁： 759-765 2010年10月

Sex-Specific HDL Cholesterol Changes With Weight Loss and Their Association With Anthropometric Variables: The LIFE Study 査読有り国際共著

Yatsuya H, Jeffery RW, Erickson DJ, Welsh EM, Flood AP, Jaeb MA, Laqua PS, Mitchell NR, Langer SL, Levy RL

Obesity (Silver Spring) Epub 巻 2010年9月

Associations of obesity measures with subtypes of ischemic stroke in the ARIC Study. 査読有り国際共著 Open Access

Yatsuya H, Yamagishi K, North KE, Brancati FL, Stevens J, Folsom AR; ARIC Study Investigators.

J Epidemiol 20 巻 ( 5 ) 頁： 347-354 2010年9月

Risk of incident cardiovascular disease among users of smokeless tobacco in the Atherosclerosis Risk in Communities (ARIC) study. 査読有り国際共著

Yatsuya H, Folsom AR; ARIC Investigators.

Am J Epidemiol 172 巻 ( 5 ) 頁： 600-605 2010年9月

Body mass index and risk of stroke and myocardial infarction in a relatively lean population: meta-analysis of 16 Japanese cohorts using individual data. 査読有り

Yatsuya H, Toyoshima H, Yamagishi K, Tamakoshi K, Taguri M, Harada A, Ohashi Y, Kita Y, Naito Y, Yamada M, Tanabe N, Iso H, Ueshima H; Japan Arteriosclerosis Longitudinal Study (JALS) group.

Circ Cardiovasc Qual Outcomes. 3 巻 ( 5 ) 頁： 498-505 2010年9月

Maintenance-tailored therapy vs. standard behavior therapy for 30-month maintenance of weight loss. 査読有り国際共著

Levy RL, Jeffery RW, Langer SL, Graham DJ, Welsh EM, Flood AP, Jaeb MA, Laqua PS, Finch EA, Hotop AM, Yatsuya H.

Prev Med Epub 巻 2010年9月

Incidence of metabolic syndrome according to combinations of lifestyle factors among middle-aged Japanese male workers. 査読有り

Li Y, Yatsuya H, Iso H, Tamakoshi K, Toyoshima H.

Prev Med 51 巻 ( 2 ) 頁： 118-122 2010年8月

Retinal microvascular abnormalities and risk of lacunar stroke: Atherosclerosis Risk in Communities Study 査読有り国際共著

Yatsuya H, Folsom AR, Wong TY, Klein R, Klein BE, Sharrett AR; ARIC Study Investigators.

Stroke 41 巻 ( 7 ) 頁： 1349-1355 2010年7月

Demographic and cardiovascular risk factors modify association of fasting insulin with incident coronary heart disease and ischemic stroke (from the Atherosclerosis Risk In Communities Study). 査読有り国際共著

Rasmussen-Torvik LJ, Yatsuya H, Selvin E, Alonso A, Folsom AR.

Am J Cardiol 105 巻 ( 10 ) 頁： 1420-1425 2010年5月

Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese. 査読有り

Muramatsu T, Yatsuya H, Toyoshima H, Sasaki S, Li Y, Otsuka R, Wada K, Hotta Y, Mitsuhashi H, Matsushita K, Murohara T, Tamakoshi K.

Prev Med. 50 巻 ( 5-6 ) 頁： 272-276 2010年5月

Race- and Sex-Specific Associations of Obesity Measures With Ischemic Stroke Incidence in the Atherosclerosis Risk in Communities (ARIC) Study 査読有り国際共著

Yatsuya H, Folsom AR, Yamagishi K, North KE, Brancati FL, Stevens J; for the ARIC Study Investigators

Stroke 41 巻 ( 3 ) 頁： 417-425 2010年3月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND AND PURPOSE: Studies have suggested differences in the association between obesity and ischemic stroke in black versus white populations. In this study, we explored ischemic stroke risk in relation to a variety of obesity measures by sex and race. METHODS: Using data from the Atherosclerosis Risk in Communities Study, we obtained information on body mass index, waist circumference, and waist-to-hip ratio from 13 549 black and white participants who were aged 45 to 65 years between 1987 and 1989. All were free of cardiovascular disease and cancer at baseline. Incident strokes over a median follow-up of 16.9 years were ascertained from hospital records. RESULTS: Although crude incidence rates of ischemic stroke varied more than 3-fold by race and sex, the relationship between higher measures of obesity and ischemic stroke risk was positive and linear across all groups. The crude incidence of ischemic stroke was 1.2 per 1000 person-years for white women with the lowest body mass index, ranging up to 8.0 per 1000 person-years for black men with the highest body mass index. Hazard ratios for the highest versus lowest quintile of body mass index, waist circumference, and waist-to-hip ratio ranged from 1.43 to 3.19, indicating increased stroke risk associated with obesity, however it was measured, even after adjustment for potential confounders. Additional adjustment for factors that may mediate the relationship, such as diabetes and hypertension, significantly attenuated the associations, suggesting that these factors may explain much of the stroke risk associated with obesity. CONCLUSIONS: Degree of obesity, defined by body mass index, waist circumference, or waist-to-hip ratio, was a significant risk factor for ischemic stroke regardless of sex or race.

DOI： 10.1161/STROKEAHA.109.566299

Daytime napping and mortality, with a special reference to cardiovascular disease: the JACC study 査読有り

Tanabe N, Iso H, Seki N, Suzuki H, Yatsuya H, Toyoshima H, Tamakoshi A; for the JACC Study Group

Int J Epidemiol 39 巻 ( 1 ) 頁： 233-243 2010年2月

BMI and all-cause mortality among Japanese older adults: findings from the Japan collaborative cohort study. 査読有り

Tamakoshi A, Yatsuya H, Lin Y, Tamakoshi K, Kondo T, Suzuki S, Yagyu K, Kikuchi S; JACC Study Group

Obesity (Silver Spring) 18 巻 ( 2 ) 頁： 362-369 2010年2月

Vaginal douching in Cambodian women: its prevalence and association with vaginal candidiasis 査読有り国際共著 Open Access

Heng LS, Yatsuya H, Morita S, Sakamoto J

J Epidemiol 20 巻 ( 1 ) 頁： 70-76 2010年

Changes in C-reactive protein during weight loss and the association with changes in anthropometric variables in men and women: LIFE Study. 査読有り国際共著

Yatsuya H, Jeffery RW, Langer SL, Mitchell N, Flood AP, Welsh EM, Jaeb MA, Laqua PS, Crowell M, Levy RL

Int J Obes (Lond). Epub 巻 2010年

Factors predicting growth of vestibular schwannoma in neurofibromatosis type 2. 査読有り

Ito E, Saito K, Yatsuya H, Nagatani T, Otsuka G

Neurosurg Rev 32 巻 ( 4 ) 頁： 425-433 2009年10月

Changes in activities of dail living, physical fitness, and depressive symptoms after six-month periodic well-rounded exercise programs for older adults living in nursing homes or special nursing facilities 査読有り Open Access

Ouyang P, Yatsuya H, Toyoshima H, Otsuka R, Wada K, Matsushita K, Ishikawa M, Lee Y, Hotta Y, Mitsuhashi H, Muramatsu T, Kasuga N, Tamakoshi K

Nagoya J Med Sci 71 巻 ( 3-4 ) 頁： 115-126 2009年9月

Multilevel analyses of effects of variation in body mass index on serum lipid concentrations in middle-aged Japanese men. 査読有り Open Access

Kondo T, Kimata A, Yamamoto K, Ueyama S, Ueyama J, Yatsuya H, Tamakoshi K, Hori Y

Nagoya J Med Sci 71 巻 ( 1-2 ) 頁： 19-28 2009年2月

Upper airway morphology in patients with obstructive sleep apnea syndrome: Effects of lateral positioning. 査読有り

Soga T, Nakata S, Yasuma F, Noda A, Sugiura T, Yatsuya H, Koike Y, Ozaki N, Nakashima T.

Auris Nasus Larynx 36 巻 ( 3 ) 頁： 305-309 2009年1月

An influence of Interferon-gamma gene polymorphisms on treatment response to tuberculosis in Japanese population. 査読有り

Shibasaki M, Yagi T, Yatsuya H, Okamoto M, Nishikawa M, Baba H, Hashimoto N, Senda K, Kawabe T, Nakashima K, Imaizumi K, Shimokata K, Hasegawa Y

J Infect 58 巻 ( 6 ) 頁： 467-469 2009年1月

Uric Acid and left ventricular hypertrophy in Japanese men. 査読有り Open Access

Mitsuhashi H, Yatsuya H, Matsushita K, Zhang H, Otsuka R, Muramatsu T, Takefuji S, Hotta Y, Kondo T, Murohara T, Toyoshima H, Tamakoshi K.

Circ J 73 巻 ( 4 ) 頁： 667-672 2009年

Group education with personal rehabilitation for idiopathic Parkinson's disease. 査読有り国際共著

Guo L, Jiang Y, Yatsuya H, Yoshida Y, Sakamoto J.

Can J Neurol Sci 36 巻 ( 1 ) 頁： 51-59 2009年

Effect of the interaction between mental stress and eating pattern on body mass index gain in healthy Japanese male workers. 査読有り Open Access

Toyoshima H, Masuoka N, Hashimoto S, Otsuka R, Sasaki S, Tamakoshi K, Yatsuya H.

J Epidemiol 19 巻 ( 2 ) 頁： 88-93 2009年

Contribution of adipocytokines to low-grade inflammatory state as expressed by circulating C-reactive protein in Japanese men: comparison of leptin and adiponectin. 査読有り

Sugiura K, Tamakoshi K, Yatsuya H, Otsuka R, Wada K, Matsushita K, Kondo T, Hotta Y, Mitsuhashi H, Murohara T, Toyoshima H.

Int J Cardiol 130 巻 ( 2 ) 頁： 159-164 2008年

Effect of physical activity on breast cancer risk: findings of the Japan collaborative cohort study. 査読有り

Suzuki S, Kojima M, Tokudome S, Mori M, Sakauchi F, Fujino Y, Wakai K, Lin Y, Kikuchi S, Tamakoshi K, Yatsuya H, Tamakoshi A; Japan Collaborative Cohort Study Group.

Cancer Epidemiol Biomarkers Prev 17 巻 ( 12 ) 頁： 3396-3401 2008年

Development and validity of the Japanese version of body shape silhouette: relationship between self-rating silhouette and measured body mass index. 査読有り Open Access

Nagasaka K, Tamakoshi K, Matsushita K, Toyoshima H, Yatsuya H.

Nagoya J Med Sci 70 巻 ( 3-4 ) 頁： 89-96 2008年

Self-reported medical history was generally accurate among Japanese workplace population. 査読有り

Wada K, Yatsuya H, Ouyang P, Otsuka R, Mitsuhashi H, Takefuji S, Matsushita K, Sugiura K, Hotta Y, Toyoshima H, Tamakoshi K.

J Clin Epidemiol 62 巻 ( 3 ) 頁： 306-313 2008年

Having more healthy practice was associated with low white blood cell counts in middle-aged Japanese male and female workers. 査読有り

Otsuka R, Tamakoshi K, Wada K, Matsushita K, Ouyang P, Hotta Y, Takefuji S, Mitsuhashi H, Toyoshima H, Shimokata H, Yatsuya H.

Ind Health 46 巻 ( 4 ) 頁： 341-347 2008年

TH1/TH2 immune response in lung fibroblasts in interstitial lung disease. 査読有り

Sumida A, Hasegawa Y, Okamoto M, Hashimoto N, Imaizumi K, Yatsuya H, Yokoi T, Takagi K, Shimokata K, Kawabe T.

Arch Med Res 39 巻 ( 5 ) 頁： 503-510 2008年

Further inflammatory information on metabolic syndrome by adiponectin evaluation. 査読有り

Int J Cardiol 124 巻 ( 3 ) 頁： 339-344 2008年

Low leptin but high insulin resistance of smokers in Japanese men. 査読有り

Hotta Y, Yatsuya H, Toyoshima H, Matsushita K, Mitsuhashi H, Takefuji S, Oiso Y, Tamakoshi K.

Diabetes Res Clin Pract 81 巻 ( 3 ) 頁： 358-364 2008年

記述言語：英語掲載種別：研究論文（学術雑誌）

We investigated the association between smoking and leptin, and to discuss their influence on diabetes in a large-scale study of Japanese men. METHODS: A cross-sectional study was carried out in 2002. The subjects were 2836 men aged 35-66. Smoking history was investigated in a self-administered questionnaire. Blood leptin, glucose and insulin were measured. RESULTS: Significant differences in leptin levels and homeostasis model assessment of insulin resistance (HOMA-IR) related to smoking status were observed (P=0.001 and P=0.008, respectively). The multivariate-adjusted geometric means of leptin in current, past and never smokers were 3.88, 4.08 and 4.12 ng/ml, respectively, while the means of HOMA-IR were 1.64, 1.61 and 1.49, respectively. The age-, body mass index-, and other lifestyle-adjusted prevalences of diabetes in current and never smokers were 9.2 and 4.7%, respectively. That of current smokers was significantly higher than in never smokers (P<0.001). The dose-dependent association found between the intensity of smoking and leptin levels in current smokers was statistically significant (P=0.030). CONCLUSIONS: The present finding may explain in part an association among smoking, leptin levels and diabetes. Smoking is one of the important modifiable risk factors for the prevention of diabetes.

DOI： 10.1016/j.diabres.2008.05.005

Association between low birth weight and elevated white blood cell count in adulthood within a Japanese population. 査読有り Open Access

Wada K, Tamakoshi K, Ouyang P, Otsuka R, Mitsuhashi H, Takefuji S, Matsushita K, Sugiura K, Hotta Y, Toyoshima H, Yatsuya H.

Circ J 72 巻 ( 5 ) 頁： 757-763 2008年

Active smoking, passive smoking, and breast cancer risk: findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. 査読有り Open Access

Lin Y, Kikuchi S, Tamakoshi K, Wakai K, Kondo T, Niwa Y, Yatsuya H, Nishio K, Suzuki S, Tokudome S, Yamamoto A, Toyoshima H, Mori M, Tamakoshi A; Japan Collaborative Cohort Study Group for Evaluation of Cancer Risk.

J Epidemiol 18 巻 ( 2 ) 頁： 77-83 2008年

Eating fast leads to insulin resistance: findings in middle-aged Japanese men and women. 査読有り

Otsuka R, Tamakoshi K, Yatsuya H, Wada K, Matsushita K, OuYang P, Hotta Y, Takefuji S, Mitsuhashi H, Sugiura K, Sasaki S, Kral JG, Toyoshima H.

Prev Med 46 巻 ( 2 ) 頁： 154-159 2008年

Smoking status and adiponectin in healthy Japanese men and women. 査読有り

Takefuji S, Yatsuya H, Tamakoshi K, Otsuka R, Wada K, Matsushita K, Sugiura K, Hotta Y, Mitsuhashi H, Oiso Y, Toyoshima H.

Prev Med 45 巻 ( 6 ) 頁： 471-475 2007年12月

High-sensitivity C-reactive protein is quite low in Japanese men at high coronary risk. 査読有り Open Access

Matsushita K, Yatsuya H, Tamakoshi K, Yang PO, Otsuka R, Wada K, Mitsuhashi H, Hotta Y, Kondo T, Murohara T, Toyoshima H.

Circ J 71 巻 ( 6 ) 頁： 820-825 2007年

Risk factors for first acute myocardial infarction attack assessed by cardiovascular disease registry data in Aichi Prefecture. 査読有り Open Access

Kondo Y, Toyoshima H, Yatsuya H, Hirose K, Morikawa Y, Ikedo N, Masui T, Tamakoshi K.

Nagoya J Med Sci 69 巻 ( 3-4 ) 頁： 139-147 2007年

A nested case-control study of stomach cancer incidence and serum superoxide dismutase activity in the Japan Collaborative Cohort study in Japan. 査読有り

Pham TM, Fujino Y, Kikuchi S, Tamakoshi A, Yatsuya H, Kubo T, Matsuda S, Yoshimura T; JACC Study Group.

Cancer Detect Prev 31 巻 ( 6 ) 頁： 431-435 2007年

Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activities. 査読有り

Ichihara M, Murakumo Y, Masuda A, Matsuura T, Asai N, Jijiwa M, Ishida M, Shinmi J, Yatsuya H, Qiao S, Takahashi M, Ohno K.

Nucleic Acids Res 35 巻 ( 18 ) 頁： e123 2007年

Pathophysiologic mechanisms of obesity and related metabolic disorders: an epidemiologic study using questionnaire and serologic biomarkers. 招待有り Open Access

Yatsuya H.

J Epidemiol 17 巻 ( 5 ) 頁： 141-146 2007年

Reduction of inner retinal thickness in patients with autosomal dominant optic atrophy associated with OPA1 mutations. 査読有り

Ito Y, Nakamura M, Yamakoshi T, Lin J, Yatsuya H, Terasaki H.

Invest Ophthalmol Vis Sci 48 巻 ( 9 ) 頁： 4079-4086 2007年

Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients. 査読有り

Nihashi T, Yatsuya H, Hayasaka K, Kato R, Kawatsu S, Arahata Y, Iwai K, Takeda A, Washimi Y, Yoshimura K, Mizuno K, Kato T, Naganawa S, Ito K.

Radiat Med 25 巻 ( 6 ) 頁： 255-262 2007年

Consumption of soy foods and the risk of breast cancer: findings from the Japan Collaborative Cohort (JACC) Study. 査読有り

Nishio K, Niwa Y, Toyoshima H, Tamakoshi K, Kondo T, Yatsuya H, Yamamoto A, Suzuki S, Tokudome S, Lin Y, Wakai K, Hamajima N, Tamakoshi A.

Cancer Causes Control 18 巻 ( 8 ) 頁： 801-808 2007年

High-sensitivity C-reactive protein is quite low in Japanese men at high coronary risk. 査読有り Open Access

Matsushita K, Yatsuya H, Tamakoshi K, Yang PO, Otsuka R, Wada K, Mitsuhashi H, Hotta Y, Kondo T, Murohara T, Toyoshima H.

71 巻 ( 6 ) 頁： 820-825 2007年

A nested case-control study of stomach cancer and serum insulin-like growth factor (IGF)-1, IGF-2 and IGF-binding protein (IGFBP)-3. 査読有り

Pham TM, Fujino Y, Kikuchi S, Tamakoshi A, Yatsuya H, Matsuda S, Yoshimura T; JACC Study Group.

Eur J Cancer 43 巻 ( 10 ) 頁： 1611-1616 2007年

A new method of blood sampling reduces pain for newborn infants: a prospective, randomized controlled clinical trial. 査読有り

Sato Y, Fukasawa T, Hayakawa M, Yatsuya H, Hatakeyama M, Ogawa A, Kuno K.

Early Hum Dev 83 巻 ( 6 ) 頁： 389-394 2007年

The transition to menopause reinforces adiponectin production and its contribution to improvement of insulin-resistant state. 査読有り

Tamakoshi K, Yatsuya H, Wada K, Matsushita K, Otsuka R, Yang PO, Sugiura K, Hotta Y, Mitsuhashi H, Takefuji S, Kondo T, Toyoshima H.

Clin Endocrinol (Oxf) 66 巻 ( 1 ) 頁： 65-71 2007年

Lung cancer mortality and body mass index in a Japanese cohort: findings from the Japan Collaborative Cohort Study (JACC Study). 査読有り

Kondo T, Hori Y, Yatsuya H, Tamakoshi K, Toyoshima H, Nishino Y, Seki N, Ito Y, Suzuki K, Ozasa K, Watanabe Y, Ando M, Wakai K, Tamakoshi A.

Cancer Causes Control 18 巻 ( 2 ) 頁： 229-234 2007年

Psychological attitudes and risk of breast cancer in Japan: a prospective study. 査読有り

Wakai K, Kojima M, Nishio K, Suzuki S, Niwa Y, Lin Y, Kondo T, Yatsuya H, Tamakoshi K, Yamamoto A, Tokudome S, Toyoshima H, Tamakoshi A; for the JACC Study Group.

Cancer Causes Control 18 巻 ( 3 ) 頁： 259-267 2007年

Psychological factors and insomnia among male civil servants in Japan. 査読有り

Murata C, Yatsuya H, Tamakoshi K, Otsuka R, Wada K, Toyoshima H.

Sleep Med 8 巻 ( 3 ) 頁： 209-217 2007年

A nested case-control study of stomach cancer and serum insulin-like growth factor (IGF)-1, IGF-2 and IGF-binding protein (IGFBP)-3. 査読有り

Pham TM, Fujino Y, Kikuchi S, Tamakoshi A, Yatsuya H, Matsuda S, Yoshimura T; The JACC Study Group.

Eur J Cancer 43 巻 ( 10 ) 頁： 1611-1616 2007年

Impact of intensive-care-unit(ICU)-acquired ventilator-associated pneumonia(VAP) on hospital mortality: a matched-paired case-control study. 査読有り Open Access

Uno H, Takezawa J, Yatsuya H, Suka M, Yoshida K.

Nagoya J Med Sci 69 巻 ( 1-2 ) 頁： 29-36 2007年

White blood cell count and risk of all-cause and cardiovascular mortality in nationwide sample of Japanese--results from the NIPPON DATA90. 査読有り

Tamakoshi K, Toyoshima H, Yatsuya H, Matsushita K, Okamura T, Hayakawa T, Okayama A, Ueshima H; NIPPON DATA90 Research Group.

Circ J 71 巻 ( 4 ) 頁： 479-485 2007年

Adiponectin level and left ventricular hypertrophy in Japanese men. 査読有り

Mitsuhashi H, Yatsuya H, Tamakoshi K, Matsushita K, Otsuka R, Wada K, Sugiura K, Takefuji S, Hotta Y, Kondo T, Murohara T, Toyoshima H.

Hypertension 49 巻 ( 6 ) 頁： 1448-1454 2007年

Inverse association between adiponectin and C-reactive protein in substantially healthy Japanese men. 査読有り

Matsushita K, Yatsuya H, Tamakoshi K, Wada K, Otsuka R, Zhang H, Sugiura K, Kondo T, Murohara T, Toyoshima H.

Atherosclerosis 188 巻頁： 184-189 2006年9月

Perceived psychological stress and serum leptin concentrations in Japanese men. 査読有り

Otsuka R, Yatsuya H, Tamakoshi K, Matsushita K, Wada K, Toyoshima H.

Obesity (Silver Spring) 14 巻 ( 10 ) 頁： 1832-1838 2006年

Inverse association between adiponectin and C-reactive protein in substantially healthy Japanese men. 査読有り

Matsushita K, Yatsuya H, Tamakoshi K, Wada K, Otsuka R, Zhang H, Sugiura K, Kondo T, Murohara T, Toyoshima H.

Atherosclerosis 188 巻 ( 1 ) 頁： 184-189 2006年

Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men. 査読有り

Matsushita K, Yatsuya H, Tamakoshi K, Wada K, Otsuka R, Takefuji S, Sugiura K, Kondo T, Murohara T, Toyoshima H.

Arterioscler Thromb Vasc Biol 26 巻 ( 4 ) 頁： 871-876 2006年

Birth weight and adult hypertension: cross-sectional study in a Japanese workplace population. 査読有り

Tamakoshi K, Yatsuya H, Wada K, Matsushita K, Otsuka R, Yang PO, Sugiura K, Hotta Y, Mitsuhashi H, Kondo T, Toyoshima H.

Circ J 70 巻 ( 3 ) 頁： 262-267 2006年

Association between parental histories of hypertension, diabetes and dyslipidemia and the clustering of these disorders in offspring. 査読有り

Wada K, Tamakoshi K, Yatsuya H, Otsuka R, Murata C, Zhang H, Takefuji S, Matsushita K, Sugiura K, Toyoshima H.

Prev Med 42 巻 ( 5 ) 頁： 358-363 2006年

Determinants of self-rated health: could health status explain the association between self-rated health and mortality? 査読有り

Murata C, Kondo T, Tamakoshi K, Yatsuya H, Toyoshima H.

Arch Gerontol Geriatr 43 巻 ( 3 ) 頁： 369-380 2006年

Plasma fibrinogen levels and cardiovascular risk factors in Japanese schoolchildren. 査読有り Open Access

Fujii C, Sakakibara H, Kondo T, Yatsuya H, Tamakoshi K, Toyoshima H.

J Epidemiol 16 巻 ( 2 ) 頁： 64-70 2006年

Low birth weight is associated with reduced adiponectin concentration in adult. 査読有り

Tamakoshi K, Yatsuya H, Wada K, Matsushita K, Otsuka R, Sugiura K, Kondo T, Toyoshima H.

Ann Epidemiol 16 巻 ( 9 ) 頁： 669-674 2006年

Eating fast leads to obesity: findings based on self-administered questionnaires among middle-aged Japanese men and women. 査読有り Open Access

Otsuka R, Tamakoshi K, Yatsuya H, Murata C, Sekiya A, Wada K, Zhang HM, Matsushita K, Sugiura K, Takefuji S, OuYang P, Nagasawa N, Kondo T, Sasaki S, Toyoshima H.

Journal of Epidemiology 16 巻 ( 3 ) 頁： 117-124 2006年

Factors associated with life space among community-living rural elders in Japan. 査読有り

Murata C, Kondo T, Tamakoshi K, Yatsuya H, Toyoshima H.

Public Health Nurs 23 巻 ( 4 ) 頁： 324-331 2006年

Interleukin-8 gene polymorphism associated with susceptibility to non-cardia gastric carcinoma with microsatellite instability. 査読有り

Shirai K, Ohmiya N, Taguchi A, Mabuchi N, Yatsuya H, Itoh A, Hirooka Y, Niwa Y, Mori N, Goto H.

J Gastroenterol Hepatol 21 巻 ( 7 ) 頁： 1129-1135 2006年

Seasonal variations of acute massive submacular haemorrhage associated with age-related macular degeneration. 査読有り

Iguchi Y, Ito Y, Kikuchi M, Ishikawa K, Oshima H, Yatsuya H, Terasaki H.

Br J Ophthalmol 90 巻 ( 10 ) 頁： 1256-1258 2006年

Factors related to frequency of engaging in outside activities among elderly persons living an independent life at home. 査読有り Open Access

Ishikawa M, Tamakoshi K, Yatsuya H, Suma K, Wada K, Otsuka R, Matsushita K, Zhang H, Murata C, Kondo T, Toyoshima H.

Nagoya J Med Sci 68 巻 ( 3-4 ) 頁： 121-130 2006年

HIV prevalence and factors associated with HIV infection among male injection drug users under 30: a cross-sectional study in Long An, Vietnam. 査読有り国際共著 Open Access

Tran TM, Nguyen HT, Yatsuya H, Hamajima N, Nishimura A, Ito K.

BMC Public Health 10 巻 ( 6 ) 頁： 248 2006年

A positive association between leptin and blood pressure of normal range in Japanese men. 査読有り

Wada K, Yatsuya H, Tamakoshi K, Otsukai R, Fujii C, Matsushita K, Sugiura K, Toyoshima H.

Hypertens Res 29 巻 ( 7 ) 頁： 485-492 2006年

Serum levels of insulin-like growth factor I, II, and binding protein 3, transforming growth factor beta-1, soluble fas ligand and superoxide dismutase activity in stomach cancer cases and their controls in the JACC Study. 査読有り

Yatsuya H, Toyoshima H, Tamakoshi K, Tamakoshi A, Kondo T, Hayakawa N, Sakata K, Kikuchi S, Hoshiyama Y, Fujino Y, Mizoue T, Tokui N, Yoshimura T; JACC Study Group.

Journal of Epidemiology 15 巻 ( S2 ) 頁： S120-S125 2005年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The prognosis of stomach cancer with advanced stage remains poor. New biomarkers of the disease that may contribute to establish the potential screening strategy would be of value for the early detection of individuals at high risk of the disease. METHODS: We conducted a prospective, nested case-control analysis among apparently healthy men and women who were followed for up to 8 years in the Japan Collaborative Cohort (JACC) Study, to evaluate serum levels of insulin-like growth factor I, II, and binding protein 3 (IFG-I, IGF-II, and IGFBP-3), transforming growth factorbeta-1 (TGFbeta1), soluble fas (sFas) and superoxide dismutase activity (SOD) in 210 stomach cancer cases diagnosed in the JACC Study in relation to those levels in their 410 controls. RESULTS: Among 6 serum biomarkers tested for case-control differences, only sFas level in female stomach cancer cases was significantly higher than that of controls (2.22 pg/ml vs. 2.04 pg/mL, respectively; P=0.013 by two-way analysis of covariance controlling for matching variable). CONCLUSION: None of the biomarkers consistently predicted future risk of stomach cancer in both men and women in the present analysis. Serum sFas level in women, however, should be studied much more thoroughly whether it provides meaningful refinement of risk stratification, or it elucidate the mechanisms of tumorigenesis in women.

Dietary habits and stomach cancer risk in the JACC Study. 査読有り Open Access

Tokui N, Yoshimura T, Fujino Y, Mizoue T, Hoshiyama Y, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Kubo T, Tamakoshi A; JACC Study Group.

J Epidemiol 15 巻 ( S2 ) 頁： S98-S108 2005年

Dietary intakes of fat and fatty acids and risk of breast cancer: a prospective study in Japan. 査読有り

Wakai K, Tamakoshi K, Date C, Fukui M, Suzuki S, Lin Y, Niwa Y, Nishio K, Yatsuya H, Kondo T, Tokudome S, Yamamoto A, Toyoshima H, Tamakoshi A; JACC Study Group.

Cancer Sci 96 巻 ( 9 ) 頁： 590-599 2005年

Relationship between body mass index and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort (JACC) study. 査読有り

Niwa Y, Yatsuya H, Tamakoshi K, Nishio K, Kondo T, Lin Y, Suzuki S, Wakai K, Tokudome S, Yamamoto A, Hamajima N, Toyoshima H, Tamakoshi A; JACC Study Group.

J Obstet Gynaecol Res 31 巻 ( 5 ) 頁： 452-458 2005年

Mortality and incidence rates of stomach cancer in the JACC Study. 査読有り Open Access

J Epidemiol 15 巻 ( S2 ) 頁： S89-S97 2005年

突然死と性差招待有り

玉腰浩司、豊嶋英明、八谷寛.

日本臨床 63 巻頁： 1284-1288 2005年

肥満の健康影響招待有り

八谷寛、玉腰浩司、豊嶋英明.

現代医学 52 巻頁： 521-526 2005年

肥満の科学的解明とエビデンスに基づいた対策・指導招待有り

八谷寛、松下邦洋、玉腰浩司、大塚礼、和田恵子、豊嶋英明.

産業医学レビュー 18 巻頁： 71-116 2005年

職域コホート男性における血清レプチン濃度と生活習慣との関連査読有り Open Access

63 巻頁： 1284-1288 2005年

Lack of an association between serum level of transforming growth factor beta -1 and stomach cancer risk in the JACC study. 査読有り

Yatsuya H, Tamakoshi A, Tamakoshi K, Hoshiyama Y, Fujino Y, Tokui N, Mizoue T, Kikuchi S, Sakata K, Hayakawa N, Kondo T, Toyoshima H, Yoshimura T.

Asian Pacific Journal of Cancer Prevention 6 巻 ( 2 ) 頁： 170-176 2005年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Alterations in the serum concentration of transforming growth factor beta-1 (TGFbeta1) have been observed in gastric cancer patients. No study, however, has ever examined the association between the serum TGFbeta1 level and stomach cancer prospectively. We conducted a prospective, nested case-control analysis among apparently healthy men and women who were followed for up to 8 years in the JACC Study to assess whether serum level of total TGFbeta1 is associated with a subsequent risk of stomach cancer. The concentration of serum TGFbeta1 in previously collected blood samples was analyzed by ELISA for 209 individuals in whom a diagnosis of stomach cancer was documented, and for 409 controls matched with them for gender, age and study area. Baseline blood levels of TGFbeta1 were not related to the risk of stomach cancer in either men or women, a finding unchanged even after adjustment for potential confounders. The multivariate-adjusted odds ratio of stomach cancer in men and women was 1.10 (95% CI, 0.82 to 1.48) and 1.09 (95% CI, 0.80 to 1.48), respectively, for each increase of 1 SD in the TGFbeta1 value. In conclusion, serum TGFbeta1 levels were not associated with increased risks of subsequent stomach cancer.

Familial aggregation and coaggregation of history of hypertension and stroke. 査読有り

Kondo T, Toyoshima H, Tsuzuki Y, Hori Y, Yatsuya H, Tamakoshi K, Tamakoshi A, Ohno Y; JACC Study Group.

J Hum Hypertens 19 巻 ( 2 ) 頁： 119-25 2005年

Long-term body weight fluctuation is associated with metabolic syndrome independent of current body mass index among Japanese men. 査読有り Open Access

Zhang H, Tamakoshi K, Yatsuya H, Murata C, Wada K, Otsuka R, Nagasawa N, Ishikawa M, Sugiura K, Matsushita K, Hori Y, Kondo T, Toyoshima H.

Circ J 69 巻 ( 1 ) 頁： 13-8 2005年

Impact of menstrual and reproductive factors on breast cancer risk in Japan: results of the JACC study. 査読有り

Tamakoshi K, Yatsuya H, Wakai K, Suzuki S, Nishio K, Lin Y, Niwa Y, Kondo T, Yamamoto A, Tokudome S, Toyoshima H, Tamakoshi A; JACC Study Group.

Cancer Sci 96 巻 ( 1 ) 頁： 57-62 2005年

Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women. 査読有り

Mabuchi T, Yatsuya H, Tamakoshi K, Otsuka R, Nagasawa N, Zhang H, Murata C, Wada K, Ishikawa M, Hori Y, Kondo T, Hashimoto S, Toyoshima H.

Diabetes Metab Res Rev 21 巻 ( 5 ) 頁： 441-7 2005年

Cigarette smoking and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort study. 査読有り

Niwa Y, Wakai K, Suzuki S, Tamakoshi K, Lin Y, Yatsuya H, Kondo T, Nishio K, Yamamoto A, Tokudome S, Hamajima N, Toyoshima H, Tamakoshi A; JACC Study Group.

J Obstet Gynaecol Res 31 巻 ( 2 ) 頁： 144-51 2005年

Prospective study of alcohol consumption and breast cancer risk in Japanese women. 査読有り

Lin Y, Kikuchi S, Tamakoshi K, Wakai K, Kondo T, Niwa Y, Yatsuya H, Nishio K, Suzuki S, Tokudome S, Yamamoto A, Toyoshima H, Tamakoshi A.

Int J Cancer 116 巻 ( 5 ) 頁： 779-83 2005年

Validity of self-reported height and weight in a Japanese workplace population. 査読有り

Wada K, Tamakoshi K, Tsunekawa T, Otsuka R, Zhang H, Murata C, Nagasawa N, Matsushita K, Sugiura K, Yatsuya H, Toyoshima H.

Int J Obes Relat Metab Disord 29 巻 ( 9 ) 頁： 1093-9 2005年

Effects of social relationships on mortality among the elderly in a Japanese rural area: an 88-month follow-up study. 査読有り Open Access

Murata C, Takaaki K, Hori Y, Miyao D, Tamakoshi K, Yatsuya H, Sakakibara H, Toyoshima H.

J Epidemiol 15 巻 ( 3 ) 頁： 78-84 2005年

Gender difference of sudden death 招待有り

Tamakoshi K, Toyoshima H, Yatsuya H.

Nippon Rinsho 63 巻 ( 7 ) 頁： 1284-8 2005年

Leptin is associated with an increased female colorectal cancer risk: a nested case-control study in Japan. 査読有り

Tamakoshi K, Toyoshima H, Wakai K, Kojima M, Suzuki K, Watanabe Y, Hayakawa N, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki S, Kawado M, Ozasa K, Ito Y, Tamakoshi A.

Oncology 68 巻 ( 4-6 ) 頁： 454-61 2005年

Green tea and stomach cancer--a short review of prospective studies. 査読有り

Hoshiyama Y, Kawaguchi T, Miura Y, Mizoue T, Tokui N, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Tamakoshi A, Yoshimura T; JACC Study Group.

J Epidemiol 15 巻 ( S2 ) 頁： S109-12 2005年

Cigarette smoking and mortality due to stomach cancer: findings from the JACC Study. 査読有り

Fujino Y, Mizoue T, Tokui N, Kikuchi S, Hoshiyama Y, Toyoshima H, Yatsuya H, Sakata K, Tamakoshi A, Ide R, Kubo T, Yoshimura T; JACC Study Group.

J Epidemiol 15 巻 ( S2 ) 頁： S113-S119 2005年

Serum pepsinogen values and Helicobacter pylori status among control subjects of a nested case-control study in the JACC study. 査読有り Open Access

Kikuchi S, Yagyu K, Obata Y, Yingsong L, Yatsuya H, Hoshiyama Y, Kondo T, Sakata K, Mizoue T, Tokui N, Fujino Y, Tamakoshi A, Toyoshima H, Ishibashi T, Hayakawa N, Yoshimura T; JACC Study Group.

J Epidemiol 15 巻 ( S2 ) 頁： S126-S133 2005年

出生時体重と成人期の生活習慣病との関連－胎児期起源仮説－招待有り

玉腰浩司、八谷寛、大塚礼、和田恵子、張恵明、豊嶋英明.

現代医学 52 巻頁： 321-325 2005年

Dietary intakes of fat and fatty acids and risk of breast cancer: a prospective study in Japan. 査読有り

Wakai K, Tamakoshi K, Date C, Fukui M, Suzuki S, Lin Y, Niwa Y, Nishio K, Yatsuya H, Kondo T, Tokudome S, Yamamoto A, Toyoshima H, Tamakoshi A; JACC Study Group.

Cancer Sci 96 巻 ( 9 ) 頁： 590-599 2005年

Relationship between body mass index and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort (JACC) study. 査読有り

Niwa Y, Yatsuya H, Tamakoshi K, Nishio K, Kondo T, Lin Y, Suzuki S, Wakai K, Tokudome S, Yamamoto A, Hamajima N, Toyoshima H, Tamakoshi A; JACC Study Group.

J Obstet Gynaecol Res 31 巻 ( 5 ) 頁： 452-458 2005年

Association of white blood cell count and clustered components of metabolic syndrome in Japanese men. 査読有り Open Access

Nagasawa N, Tamakoshi K, Yatsuya H, Hori Y, Ishikawa M, Murata C, Zhang H, Wada K, Otsuka R, Mabuchi T, Kondo T, Toyoshima H.

Circ J 68 巻 ( 10 ) 頁： 892-7 2004年

肥満を伴った高脂血症患者に対する運動療法の効果に関する研究　行動医学的アプローチを用いた運動習慣の定着による動脈硬化促進要因の改善に関する研究招待有り

下光輝一, 井上茂, 小田切優子, 高波嘉一, 豊嶋英明, 八谷寛, 玉腰浩司, 近藤高明, 井口ちよ

医科学応用研究財団研究報告 21 巻頁： 215-223 2004年

日本人男性における血清レプチン濃度と5年間追跡後の体重変化. 招待有り

八谷寛, 玉腰浩司, 大塚礼, 間淵智子, 和田恵子, 張恵明, 村田千代栄, 石川美由紀, 近藤高明, 豊嶋英明.

健康医科学研究助成論文集 19 巻頁： 110-117 2004年

肥満者における心血管疾患発症の過剰リスクを説明する新しい軸－血清レプチン値と白血球数の関連－招待有り

八谷寛, 淵智子, 大塚礼, 和田恵子, 長澤伸江, 張恵明, 村田千代栄, 石川美由紀, 堀容子, 近藤高明, 玉腰浩司, 豊嶋英明.

健康管理事業団研究助成論文集 10 巻頁： 19-25 2004年

Individual and joint impact of family history and Helicobacter pylori infection on the risk of stomach cancer: a nested case-control study. 査読有り

Yatsuya H, Toyoshima H, Tamakoshi A, Kikuchi S, Tamakoshi K, Kondo T, Mizoue T, Tokui N, Hoshiyama Y, Sakata K, Hayakawa N, Yoshimura T; Japan Collaborative Cohort Study Group.

British Journal of Cancer 91 巻 ( 5 ) 頁： 929-934 2004年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

We used 202 cases of stomach cancer and 394 controls nested within the Japan Collaborative Cohort Study For Evaluation of Cancer Risk (JACC study) to investigate whether family history has an independent effect on the risk of stomach cancer after controlling for the Helicobacter pylori infection. A positive history of stomach cancer in one or more first-degree relatives was associated with an increased risk of the disease in women, but not in men after controlling for H. pylori infection and other confounding variables. Women with both a family history and H. pylori infection were associated with more than five-fold increased risk of the disease (OR 5.10, 95% CI 1.58-16.5) compared to those without these factors. These results suggest the existence of inherited susceptibility to the disease in women, and that measurements of H. pylori infection together with the family history allow meaningful evaluation of risk beyond that provided by either factor alone.

Serum phospholipid transfer protein mass as a possible protective factor for coronary heart diseases. 査読有り Open Access

Yatsuya H, Tamakoshi K, Hattori H, Otsuka R, Wada K, Zhang H, Mabuchi T, Ishikawa M, Murata C, Yoshida T, Kondo T, Toyoshima H.

Circulation Journal 68 巻 ( 1 ) 頁： 11-16 2004年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Phospholipid transfer protein (PLTP) can generate pre-beta high-density lipoprotein (HDL), an efficient acceptor of peripheral cholesterol, by mediating a process called HDL conversion. The transfer of phospholipids to immature HDL is also essential in maintaining reverse cholesterol transport. The phospholipid transfer activity of PLTP has been associated with various patho-physiological conditions; however, little information is available concerning the relationship between PLTP mass and disease. METHODS AND RESULTS: Using a sandwich enzyme-linked immunosorbent assay, PLTP concentration was measured and related to the risk of developing cardiovascular disease in a worksite-based cohort of Japanese men (n=2,567). Multiple linear regression analysis showed significant associations between PLTP and HDL cholesterol, triglycerides, low-density lipoprotein cholesterol, and body mass index (standardized beta=0.395, -0.191, -0.064, and -0.064, respectively; R(2)=0.31). During the follow-up period, there were 10 cases of coronary heart disease (CHD) and 7 of stroke. The multivariate adjusted relative risk of CHD was 0.46 (95% confidence interval, 0.20-1.07) for an increase of 1 standard deviation in the PLTP value (p=0.071). PLTP concentration was not related to the risk of stroke. CONCLUSIONS: The results of this prospective study indicate that the serum PLTP concentration would serve as a predictor of CHD, independent of HDL cholesterol, triglycerides and other established risk factors.

DOI： 10.1253/circj.68.11

A nested case-control study of stomach cancer in relation to green tea consumption in Japan. 査読有り

Hoshiyama Y, Kawaguchi T, Miura Y, Mizoue T, Tokui N, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Tamakoshi A, Ohno Y, Yoshimura T; Japan Collaborative Cohort Study Group.

Br J Cancer 90 巻 ( 1 ) 頁： 135-8 2004年

A prospective study of body size and colon cancer mortality in Japan: The JACC Study. 査読有り

Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki K, Ito Y, Tamakoshi A; JACC Study Group.

Int J Obes Relat Metab Disord 28 巻 ( 4 ) 頁： 551-8 2004年

A prospective study on the possible association between having children and colon cancer risk: findings from the JACC Study. 査読有り

Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki K, Ito Y, Tamakoshi A; JACC Study Group.

Cancer Sci 95 巻 ( 3 ) 頁： 243-7 2004年

A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women: findings from the JACC study. 査読有り

Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki K, Suzuki S, Kawado M, Ozasa K, Ito Y, Tamakoshi A; JACC Study Group.

Cancer Sci 95 巻 ( 7 ) 頁： 602-7 2004年

肥満女性と結腸癌招待有り

医学のあゆみ 208 巻頁： 229-230 2004年

人間ドックの有効性と限界招待有り

玉腰浩司, 八谷寛, 豊嶋英明.

総合臨床 53 巻頁： 2435-2438 2004年

Association of flatfoot with pain, fatigue and obesity in Japanese over sixties. 査読有り Open Access

Otsuka R, Yatsuya H, Miura Y, Murata C, Tamakoshi K, Oshiro K, Nishio N, Ishikawa M, Zhang HM, Shiozawa M, Kobayashi A, Ito M, Hori Y, Kondo T, Toyoshima H.

Nippon Koshu Eisei Zasshi 50 巻 ( 10 ) 頁： 988-98 2003年10月

Effect of tactile interference stimulation of the ear in human primary somatosensory cortex: a magnetoencephalographic study. 査読有り

Nihashi T, Kakigi R, Hoshiyama M, Miki K, Kajita Y, Yoshida J, Yatsuya H.

Clin Neurophysiol 114 巻 ( 10 ) 頁： 1866-78 2003年10月

Long-term body weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese men. 査読有り

Tamakoshi K, Yatsuya H, Kondo T, Ishikawa M, Zhang H, Murata C, Otsuka R, Mabuchi T, Hori Y, Zhu S, Yoshida T, Toyoshima H.

Int J Obes Relat Metab Disord 27 巻 ( 9 ) 頁： 1059-65 2003年9月

Aggregation of stomach cancer history in parents and offspring in comparison with other sites. 査読有り

Kondo T, Toyoshima H, Tsuzuki Y, Hori Y, Yatsuya H, Tamakoshi K, Tamakoshi A, Ohno Y, Kikuchi S, Sakata K, Hoshiyama Y, Hayakawa N, Tokui N, Mizoue T, Yoshimura T.

Int J Epidemiol 頁： 579-83 2003年8月

Prospective study of screening for stomach cancer in Japan. 査読有り

Mizoue T, Yoshimura T, Tokui N, Hoshiyama Y, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Tamakoshi A, Ohno Y, Fujino Y, Kaneko S; Japan Collaborative Cohort Study Group.

Int J Cancer 106 巻 ( 1 ) 頁： 103-7 2003年8月

The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state. 査読有り

Tamakoshi K, Yatsuya H, Kondo T, Hori Y, Ishikawa M, Zhang H, Murata C, Otsuka R, Zhu S, Toyoshima H.

Int J Obes Relat Metab Disord 27 巻 ( 4 ) 頁： 443-9 2003年4月

U-shaped association between white blood cell count and fasting plasma glucose level. 査読有り

Tamakoshi K, Yatsuya H, Kondo T, Hori Y, Zhang H, Ishikawa M, Murata C, Otsuka R, Zhu S, Toyoshima H.

Diabetes Care 26 巻 ( 3 ) 頁： 950 2003年3月

The accuracy of long-term recall of past body weight in Japanese adult men. 査読有り

Tamakoshi K, Yatsuya H, Kondo T, Hirano T, Hori Y, Yoshida T, Toyoshima H.

Int J Obes Relat Metab Disord 27 巻 ( 2 ) 頁： 247-52 2003年2月

Gender and age differences in lifestyle factors related to hypertension in middle-aged civil service employees. 査読有り Open Access

Hori Y, Toyoshima H, Kondo T, Tamakoshi K, Yatsuya H, Zhu S, Kawamura T, Toyama J, Okamoto N.

J Epidemiol 13 巻 ( 1 ) 頁： 38-47 2003年1月

Reproducibility and validity of a simple checklist-type questionnaire for food intake and dietary behavior. 査読有り Open Access

Yatsuya H, Ohwaki A, Tamakoshi K, Wakai K, Koide K, Otsuka R, Mabuchi T, Murata C, Zhang H, Ishikawa M, Kondo T, Toyoshima H.

Journal of Epidemiology 13 巻 ( 5 ) 頁： 235-245 2003年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: A simple, reliable, and valid food questionnaire is needed in clinical dietary assessments, community health education, and multi-purpose epidemiologic studies to obtain a crude measure of dietary intake. METHODS: To assess the validity and reproducibility of a simple 4-point scale food intake and behavior checklist, it was compared to two 3-day weighed dietary records. The FBC was administered to 47 students of a dietician course and their parents (n = 94) over a 9-month interval to assess the reproducibility. The mean intakes of selected food groups assessed by the two dietary records completed between food intake and behavior checklists were compared to the responses to the food intake and behavior checklist to assess its validity. RESULTS: The kappa statistics for reproducibility ranged from 0.25 for confectionaries to 0.63 for a preference for fatty foods (median, 0.39). There was a reasonable level of correlation between the dietary record and the food intake and behavior checklist in the intake of eggs, milk, and fruits (r = 0.53, 0.56, and 0.50, respectively). There was a weaker but still significant correlation in the intake of vegetables, and alcohol (r = 0.31 and 0.45, respectively). No significant correlation was observed in the intake of meat, fish, confectionaries, and soft drinks. However, those who reported consuming mainly fish rather than meat were found to eat significantly less meat and animal fat. Similarly, those who did not prefer fatty foods consumed significantly less meat, animal fat, and polyunsaturated fatty acids. CONCLUSIONS: This simple food checklist was useful in collecting data on egg, milk, and fruit consumption. Assessing intake frequency of vegetables, meat or fish with the FBC may be useful in screening high- or low-intake individuals.

DOI： 10.2188/jea.13.235