研究者詳細 - 八谷　寛

論文 - 八谷　寛

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γGTPとALT追加による10年間の2型糖尿病発症リスク予測能の改善愛知職域コホート査読有り

金子佳世, 八谷寛, 李媛英, 上村真由, 江啓発, 平川仁尚, 太田充彦, 玉腰浩司, 豊嶋英明, 青山温子

日本公衆衛生学会総会抄録集 77回巻頁： 204 - 204 2018年10月

食品摂取の多様性と尿中Na,K排泄量、血圧との関連 NIPPON DATA2010

大塚礼, 八谷寛, 西信雄, 奥田奈賀子, 門田文, 由田克士, 大久保孝義, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

日本公衆衛生学会総会抄録集 77回巻頁： 322 - 322 2018年10月

The association between objective measures of residence and worksite neighborhood environment, and self-reported leisure-time physical activities: The Aichi Workers' Cohort Study. 査読有り国際誌

Li Y, Yatsuya H, Hanibuchi T, Hirakawa Y, Ota A, Uemura M, Chiang C, Otsuka R, Murata C, Tamakoshi K, Toyoshima H, Aoyama A

Preventive medicine reports 11 巻頁： 282 - 289 2018年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Preventive Medicine Reports

The possible effects of a neighborhood's built environment on physical activity have not been studied in Asian countries as much as in Western countries. The present study cross-sectionally examined the relationship between geographic information system (GIS) measured residence and worksite neighborhood walkability, and the number of parks/green spaces and sports facilities within a 1 km radius of home and workplace, with self-reported leisure-time habitual (3–4 times per week or more) walking and moderate-to-vigorous intensity habitual exercise among local government workers aged 18 to 64 years living in an urban-suburban area of Aichi, Japan in 2013. A single-level binomial regression model was used to estimate the multivariable odds ratios (ORs) and 95% confidence intervals (95% CIs). Of the 1959 male and 884 female participants, 288 (15%) and 141 (16%) reported habitual walking, respectively, and 18% and 17% reported habitual exercise, respectively. Compared with women who resided in neighborhood with a walkability index of 4–30, those living in an area with that of 35–40 were significantly more likely to engage in leisure-time habitual exercise (multivariable OR: 1.70, 95% CI: 1.08–2.68). Marginally significant positive associations were found between leisure-time habitual exercise and the residential neighborhood's number of parks/green spaces among women, as well as the number of sports facilities among men. In conclusion, a residential neighborhood environment characterized by higher walkability may contribute to the initiation or maintenance of moderate-to-vigorous intensity leisure-time exercise among working women living in an urban-suburban area of Japan.

DOI： 10.1016/j.pmedr.2018.07.007

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Pooled analysis of the associations between body mass index, total cholesterol, and liver cancer-related mortality in Japan 査読有り

Ukawa S, Tamakoshi A, Murakami Y, Kiyohara Y, Yamada M, Nagai M, Satoh A, Miura K, Ueshima H, Okamura T, Imai Y, Ohkubo T, Irie F, Iso H, Kitamura A, Ninomiya T, Nakagawa H, Nakayama T, Okayama A, Sairenchi T, Saitoh S, Sakata K, Tsuji I, Kiyama M, Miyamoto Y, Ishikawa S, Yatsuya H

Asian Pacific Journal of Cancer Prevention 19 巻 ( 8 ) 頁： 2089 - 2095 2018年8月

記述言語：英語出版者・発行元：Asian Pacific Journal of Cancer Prevention

© 2018 Asian Pacific Organization for Cancer Prevention. Objective: We employed a large-scale pooled analysis to investigate the association of liver cancer-related mortality with being overweight/obese and total cholesterol (TC) levels, since limited and inconsistent data on these associations exist in Japan. Methods: A total of 59,332 participants (23,853 men and 35,479 women) from 12 cohorts without a history of cancer who were followed for a median of 14.3 years were analyzed. A sex-specific stratified Cox proportional hazards model adjusted for age and other potential confounders was used to calculate hazard ratios (HRs) and 95% confidence intervals (CI) for liver cancer-related mortality. Results: A total of 447 participants (266 men and 181 women) died of liver cancer within the follow-up period. Individuals classified as having a high BMI (≥25.0 kg/m2) and low TC levels (< 160 mg/dL) had a significantly increased risk for liver cancer-related mortality (HR 7.05, 95% CI 4.41-11.26 in men; HR 8.07, 95% CI 4.76-13.67 in women) when compared with those in the intermediate BMI (18.5-24.9 kg/m2) and TC (160-219 mg/dL) categories. These associations remained after limiting the

DOI： 10.22034/APJCP.2018.19.8.2089

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Late-phase human herpesvirus 6B reactivation in hematopoietic stem cell transplant recipients 査読有り国際誌

Miura, H; Kawamura, Y; Hattori, F; Tanaka, M; Kudo, K; Ihira, M; Yatsuya, H; Takahashi, Y; Kojima, S; Yoshikawa, T

TRANSPLANT INFECTIOUS DISEASE 20 巻 ( 4 ) 頁： e12916 2018年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Transplant Infectious Disease

Background: We sought to determine whether late-phase human herpesvirus 6B (HHV-6B) infection in hematopoietic stem cell transplant (HSCT) recipients was associated with serious outcomes and mortality. Methods: The occurrence and course of HHV-6B infection was monitored for at least 60 days after transplant using virus isolation and real-time polymerase chain reaction. Risk factors for late-phase HHV-6B infection were examined, and the propensity score was calculated with significant risk factors. The inverse probability-weighted multivariable logistic regression analysis was performed to estimate odds ratios (ORs) and the 95% confidence intervals (95% CI) for mortality. Results: Late-phase HHV-6B infection was observed in 12/89 (13.5%) of the HSCT recipients. Older age (OR: 10.3, 95% CI: 2.1/72.9, P =.0027), hematologic malignancy (OR: 10.3, 95% CI: 1.8/97.1, P =.0063), unrelated donor transplantation (OR: 5.3, 95% CI: 1.1/36.0, P =.0345), and sex-mismatched donor transplantation (OR: 6.3, 95% CI: 1.4/39.5, P =.0149) were identified as risk factors for late-phase HHV-6B infection. Fifteen subjects died (17%). Inverse probability-weighted multivariable logistic model analysis revealed that late-phase HHV-6B infection was an independent risk factor for mortality (OR: 4.2, 95% CI: 1.7/11.0, P =.0012). Among 5 of the fatal cases of late-phase HHV-6B infection, viral infection might be associated with severe clinical manifestations. Conclusion: Late-phase HHV-6B infection in HSCT recipients was associated with worse outcomes. The full spectrum of clinical features of the infection has not been fully elucidated, and therefore, recipients with high-risk factors for late-phase HHV-6B infection should be carefully monitored.

DOI： 10.1111/tid.12916

Effect of laughter yoga on salivary cortisol and dehydroepiandrosterone among healthy university students: A randomized controlled trial 査読有り国際誌

Fujisawa, A; Ota, A; Matsunaga, M; Li, YY; Kakizaki, M; Naito, H; Yatsuya, H

COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE 32 巻頁： 6 - 11 2018年8月

Cardiovascular disease mortality in relation to physical activity during adolescence and adulthood in Japan: Does school-based sport club participation matter? 査読有り国際共著国際誌

Gero, K; Iso, H; Kitamura, A; Yamagishi, K; Yatsuya, H; Tamakoshi, A

PREVENTIVE MEDICINE 113 巻頁： 102 - 108 2018年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ACADEMIC PRESS INC ELSEVIER SCIENCE

We examined potential associations of sport club participation during adolescence and sports-related physical activity during adulthood with mortality from cardiovascular diseases (CVD) in a Japanese population. Between 1988 and 1990, 29,526 men and 41,043 women aged 40-79 years responded to a questionnaire including questions about the frequency of sports participation at baseline and sport club participation during junior/senior high school. Subjects were followed-up until the end of 2009, and 4230 cardiovascular deaths (870 CHD, 1859 stroke) were identified. Cox proportional-hazard regression models were used to estimate hazard ratios (HR). During the first-two thirds of the follow-up - where the proportional hazards assumption was met - the multivariate-adjusted HR (95% confidence interval) for total CVD mortality was 0.77 (0.61-0.98) among men and 0.82 (0.61-1.10) among women who were physically active at baseline (≥5 h/week versus 1-2 h/week). The corresponding HRs for coronary heart disease (CHD) mortality were 0.65 (0.39-1.07) and 0.40 (0.17-0.91), respectively. The combined associations of sports participation during adulthood and adolescence were also examined. Am

DOI： 10.1016/j.ypmed.2018.05.012

Non-communicable disease risk factor profile among public employees in a regional city in northern Ethiopia 査読有り国際共著国際誌

Gebremariam, LW; Chiang, C; Yatsuya, H; Hilawe, EH; Kahsay, AB; Godefays, H; Abraham, L; Hirakawa, Y; Iso, H; Aoyama, A

SCIENTIFIC REPORTS 8 巻 ( 1 ) 頁： 9298 2018年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

The burden of non-communicable diseases (NCDs) is increasing in Ethiopia. This study aims to describe the prevalence of NCD risk factors of public employees in a regional city in northern Ethiopia. We conducted a cross-sectional epidemiological study targeting men and women aged 25-64 years employed by public offices in Mekelle. The prevalence was age-standardized to the Ethiopian 2007 population. Among the 1380 subjects (823 men and 557 women), 68.7% had less than 1 serving of fruits and vegetables per day, 41.0% were physically inactive, and 57.3% observed religious fast. The age-standardised prevalence of abdominal obesity was 29.3% in men and 58.5% in women, but that of metabolic syndrome was comparable between men (39.2%) and women (39.0%). The prevalence of diabetes was underestimated if only fasting blood glucose (FBG) was used for the diagnosis compared to combination of FBG and glycated haemoglobin (HbA1c) (6.7% in men and 3.8% in women vs. 12.1% in men and 5.6% in women). More than a quarter (26.1%) of men and 8.7% of women had estimated 10-year risk of cardiovascular disease of 10% or more. This study revealed the high prevalence of NCD metabolic risk factors among the urban public employees in the highland of Ethiopia.

DOI： 10.1038/s41598-018-27519-6

Association of extremely high levels of high-density lipoprotein cholesterol with cardiovascular mortality in a pooled analysis of 9 cohort studies including 43,407 individuals: The EPOCH–JAPAN study 査読有り

Hirata A, Sugiyama D, Watanabe M, Tamakoshi A, Iso H, Kotani K, Kiyama M, Yamada M, Ishikawa S, Murakami Y, Miura K, Ueshima H, Okamura T, Okamura T, Imai Y, Ohkubo T, Irie F, Iso H, Kitamura A, Ninomiya T, Kiyohara Y, Miura K, Murakami Y, Nakagawa H, Nakayama T, Okayama A, Sairenchi T, Saitoh S, Sakata K, Tamakoshi A, Tsuji I, Yamada M, Miyamoto Y, Ishikawa S, Yatsuya H

Journal of Clinical Lipidology 12 巻 ( 3 ) 頁： 674 - 684.e5 2018年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Clinical Lipidology

© 2018 National Lipid Association Background: The effect of very high or extremely high levels of high-density lipoprotein cholesterol (HDL-C) on cardiovascular disease (CVD) is not well described. Although a few recent studies have reported the adverse effects of extremely high levels of HDL-C on CVD events, these did not show a statistically significant association between extremely high levels of HDL-C and cause-specific CVD mortality. In addition, Asian populations have not been studied. Objective: We examine the impact of extremely high levels of HDL-C on cause-specific CVD mortality using pooled data of Japanese cohort studies. Methods: We performed a large-scale pooled analysis of 9 Japanese cohorts including 43,407 participants aged 40–89 years, dividing the participants into 5 groups by HDL-C levels, including extremely high levels of HDL-C ≥2.33 mmol/L (≥90 mg/dL). We estimated the adjusted hazard ratio of each HDL-C category for all-cause death and cause-specific deaths compared with HDL-C 1.04–1.55 mmol/L (40–59 mg/dL) using a cohort-stratified Cox proportional hazards model. Results: During a 12.1-year follow-up, 4995 all-cause deaths and 1280 deaths due to

DOI： 10.1016/j.jacl.2018.01.014

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降圧剤の投与は高血圧ラット肝臓Cyp7a1プロモーターのメチル化頻度を低下させる

内藤久雄, 三宅邦夫, 袁援, 橋本沙幸, 浅野友美, 北森一哉, 八谷寛, 那須民江

産業衛生学雑誌 60 巻 ( 臨増 ) 頁： 303 - 303 2018年5月

Association between average daily television viewing time and the incidence of ovarian cancer: findings from the Japan Collaborative Cohort Study 査読有り国際誌

Ukawa, S; Tamakoshi, A; Mori, M; Ikehara, S; Shirakawa, T; Yatsuya, H; Iso, H

CANCER CAUSES & CONTROL 29 巻 ( 2 ) 頁： 213 - 219 2018年2月

Relationships among Socioeconomic Factors and Self-rated Health in Japanese Adults: NIPPON DATA2010 査読有り

Ota, A; Yatsuya, H; Nishi, N; Okuda, N; Ohkubo, T; Hayakawa, T; Kadota, A; Okayama, A; Miura, K

JOURNAL OF EPIDEMIOLOGY 28 巻 ( Supplement_III ) 頁： S66 - S72 2018年

A Point System for Predicting 10-Year Risk of Developing Type 2 Diabetes Mellitus in Japanese Men: Aichi Workers' Cohort Study 査読有り

Yatsuya Hiroshi, Li Yuanying, Hirakawa Yoshihisa, Ota Atsuhiko, Matsunaga Masaaki, Haregot Hilawe Esayas, Chiang Chifa, Zhang Yan, Tamakoshi Koji, Toyoshima Hideaki, Aoyama Atsuko

JOURNAL OF EPIDEMIOLOGY 28 巻 ( 8 ) 頁： 347 - 352 2018年

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: Relatively little evidence exists for type 2 diabetes mellitus (T2DM) prediction models from long-term follow-up studies in East Asians. This study aims to develop a point-based prediction model for 10-year risk of developing T2DM in middle-aged Japanese men. Methods: We followed 3,540 male participants of Aichi Workers’ Cohort Study, who were aged 35–64 years and were free of diabetes in 2002, until March 31, 2015. Baseline age, body mass index (BMI), smoking status, alcohol consumption, regular exercise, medication for dyslipidemia, diabetes family history, and blood levels of triglycerides (TG), high density lipoprotein cholesterol (HDLC) and fasting blood glucose (FBG) were examined using Cox proportional hazard model. Variables significantly associated with T2DM in univariable models were simultaneously entered in a multivariable model for determination of the final model using backward variable selection. Performance of an existing T2DM model when applied to the current dataset was compared to that obtained in the present study’s model. Results: During the median follow-up of 12.2 years, 342 incident T2DM cases were documented. The prediction system using points assigned to age, BMI, smoking status, diabetes family history, and TG and FBG showed reasonable discrimination (c-index: 0.77) and goodness-of-fit (Hosmer-Lemeshow test, P = 0.22). The present model outperformed the previous one in the present subjects. Conclusion: The point system, once validated in the other populations, could be applied to middle-aged Japanese male workers to identify those at high risk of developing T2DM. In addition, further investigation is also required to examine whether the use of this system will reduce incidence.

DOI： 10.2188/jea.JE20170048

[Study on the probability of incident stroke and acute myocardial infarction using DPC data]. 査読有り

Kakizaki M, Sawada N, Yamagishi K, Yatsuya H, Saito I, Kokubo Y, Iso H, Tsugane S, Yasunaga H

[Nihon koshu eisei zasshi] Japanese journal of public health 65 巻 ( 4 ) 頁： 179 - 186 2018年

肥満と動脈硬化

八谷寛, 李媛英, 金子佳世, 太田充彦

食と医療 4 巻頁： 72 - 79 2018年

Prevalence of non-communicable disease risk factors among poor shantytown residents in Dhaka, Bangladesh: a community-based cross-sectional survey 査読有り国際共著国際誌

Khalequzzaman, M; Chiang, C; Choudhury, SR; Yatsuya, H; Al-Mamun, MA; Al-Shoaibi, AAA; Hirakawa, Y; Hoque, BA; Islam, SS; Matsuyama, A; Iso, H; Aoyama, A

BMJ OPEN 7 巻 ( 11 ) 頁： e014710 2017年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMJ Open

Objectives This study aims to describe the prevalence of non-communicable disease (NCD) risk factors among the urban poor in Bangladesh. Design We conducted a community-based cross-sectional epidemiological study. Setting The study was conducted in a shantytown in the city of Dhaka. There were 8604 households with 34 170 residents in the community. Those households were categorised into two wealth strata based on the housing structure. Participants The study targeted residents aged 18-64 years. A total of 2986 eligible households with one eligible individual were selected by simple random sampling stratified by household wealth status. A total of 2551 residents completed the questionnaire survey, and 2009 participated in the subsequent physical and biochemical measurements. Outcome measures A modified WHO survey instrument was used for assessing behavioural risk factors and physical and biochemical measurements, including glycated haemoglobin (HbA1c). The prevalence of NCD risk factors, such as tobacco use, fruit and vegetable intake, overweight/obesity, hypertension, diabetes (HbA1c ≥6.5%) and dyslipidaemia, was described according to household wealth status and gender differences. Results The prevalence of current tobacco use was 60.4% in men and 23.5% in women. Most of them (90.8%) consumed more than 1 serving of fruits and vegetables per day; however, only 2.1% consumed more than 5 servings. Overweight/obesity was more common in women (39.2%) than in men (18.9%), while underweight was more common in men (21.0%) than in women (7.1%). The prevalence of hypertension was 18.6% in men and 20.7% in women. The prevalence of diabetes was 15.6% in men and 22.5% in women, which was much higher than the estimated national prevalence (7%). The prevalence of raised total cholesterol (≥190 mg/dL) was 25.7% in men and 34.0% in women. Conclusion The study identified that tobacco use, both overweight and underweight, diabetes, hypertension and dyslipidaemia were prevalent among the urban poor in Bangladesh.

DOI： 10.1136/bmjopen-2016-014710

Alcohol consumption and mortality from aortic disease among Japanese men: The Japan Collaborative Cohort study 査読有り国際誌

Shirakawa, T; Yamagishi, K; Yatsuya, H; Tanabe, N; Tamakoshi, A; Iso, H

ATHEROSCLEROSIS 266 巻頁： 64 - 68 2017年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Atherosclerosis

Background and aims Only a few population-based prospective studies have examined the association between alcohol consumption and abdominal aortic aneurysm, and the results are inconsistent. Moreover, no evidence exists for aortic dissection. We examined the effect of alcohol consumption on risk of mortality from aortic diseases. Methods A total of 34,720 men from the Japan Collaborative Cohort study, aged 40–79 years, without history of cardiovascular disease and cancer at baseline 1988 and 1990 were followed up until the end of 2009 for their mortality and its underlying cause. Hazard ratios of mortality from aortic diseases were estimated according to alcohol consumption categories of never-drinkers, ex-drinkers, regular drinkers of ≤30 g, and >30 g ethanol per day. Results During the median 17.9-year follow-up period, 45 men died of aortic dissection and 41 men died of abdominal aortic aneurysm. Light to moderate drinkers of ≤30 g ethanol per day had lower risk of mortality from total aortic disease and aortic dissection compared to never-drinkers. The respective multivariable hazard ratios (95% confidence intervals) were 0.46 (0.28–0.76) for total aortic disease and 0.16 (0.05–0.50) for aortic dissection. Heavy drinkers of >30 g ethanol per day did not have reduced risk of mortality from total aortic disease, albeit had risk variation between aortic dissection and abdominal aortic aneurysm. Conclusions Light to moderate alcohol consumption was associated with reduced mortality from aortic disease among Japanese men.

DOI： 10.1016/j.atherosclerosis.2017.08.025

Association of high-density lipoprotein cholesterol concentration with different types of stroke and coronary heart disease: The Japan Public Health Center-based prospective (JPHC) study 査読有り国際誌

Saito, I; Yamagishi, K; Kokubo, Y; Yatsuya, H; Iso, H; Sawada, N; Inoue, M; Tsugane, S

ATHEROSCLEROSIS 265 巻頁： 147 - 154 2017年10月

Functional capacity, self-rated health status, and psychosocial characteristics of employed cancer survivors in Japan 査読有り国際誌

Katoh Y, Ota A, Yatsuya H, Li Y, Naito H, Fujisawa A, Matsunaga M, Hirakawa Y, Chiang C, Toyoshima H, Tamakoshi K, Aoyama A

Fujita Medical Journal 3 巻 ( 3 ) 頁： 55 - 61 2017年8月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：藤田学園医学会

Objectives: This study investigated restrictions in functional capacity, self-rated health status (SRHS), and psychosocial characteristics of employed cancer survivors in Japan and examined differences in these characteristics between cancer survivors and employees without cancer history.Methods: A cross-sectional survey was carried out. Subjects were local government employees in Japan in 2013 (n=5,474). Using a self-administered questionnaire, we evaluated restrictions in functional capacity, SRHS, and the following psychosocial characteristics: social support, perceived stress, social capital, positive reasons for living (ikigai), and happiness. We examined whether cancer history was associated with restrictions in functional capacity, SRHS, and psychosocial characteristics.Results: A total of 112 employees were cancer survivors. Of these, males of all ages and comparatively younger females had restrictions in functional capacity more frequently than the corresponding subjects without cancer history (males of all ages: 14.5% vs. 2.9%, p<0.001; females <50 years: 15.2% vs. 1.1%, p<0.001). Among males of all ages, cancer survivors reported bad SRHS more frequently than employees without cancer history (8.1% vs. 1.5%, p=0.003). No significant differences were found in psychosocial characteristics by cancer history.Conclusions: Male and comparatively young female employed cancer survivors frequently experienced restrictions in functional capacity. Male employed cancer survivors self-rated their health status as bad more frequently than male employees without cancer history.

DOI： 10.20407/fmj.3.3_55

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A pooled analysis of the association of isolated low levels of high-density lipoprotein cholesterol with cardiovascular mortality in Japan 査読有り

Takumi Hirata, Daisuke Sugiyama, Shin-ya Nagasawa, Yoshitaka Murakami, Shigeyuki Saitoh, Akira Okayama, Hiroyasu Iso, Fujiko Irie, Toshimi Sairenchi, Yoshihiro Miyamoto, Michiko Yamada, Shizukiyo Ishikawa, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura, for the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) Research Group, Hirotsugu Ueshima, Tomonori Okamura, Yutaka Imai, Takayoshi Ohkubo, Fujiko Irie, Hiroyasu Iso, Akihiko Kitamura, Yutaka Kiyohara, Katsuyuki Miura, Yoshitaka Murakami, Hideaki Nakagawa, Takeo Nakayama, Akira Okayama, Toshimi Sairenchi, Shigeyuki Saitoh, Kiyomi Sakata, Akiko Tamakoshi, Ichiro Tsuji, Michiko Yamada, Masahiko Kiyama, Yoshihiro Miyamoto, Shizukiyo Ishikawa, Hiroshi Yatsuya, Tomonori Okamura

European Journal of Epidemiology 32 巻 ( 7 ) 頁： 547 - 557 2017年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Netherlands

Low levels of serum high-density lipoprotein cholesterol (HDL-C) have been shown to be associated with increased risk of coronary heart disease (CHD). However, because this is usually observed in the context of other lipid abnormalities, it is not known whether isolated low serum HDL-C levels are an independent risk factor for CHD. We performed a large pooled analysis in Japan using data from nine cohorts with 41,206 participants aged 40–89 years who were free of cardiovascular disease at baseline. We divided participants into three groups: isolated low HDL-C, non-isolated low HDL-C, and normal HDL-C. Cohort-stratified Cox proportional hazards models were used to estimate multivariate-adjusted hazard ratios (HRs) for death due to CHD, ischemic stroke, and intracranial cerebral hemorrhage
during a 12.9-year follow-up, we observed 355, 286, and 138 deaths, respectively, in these groups. Non-isolated low HDL-C was significantly associated with increased risk of CHD compared with normal HDL-C (HR 1.37, 95 % confidence interval (CI) 1.04–1.80)
however, isolated low HDL-C was not. Although isolated low HDL-C was significantly associated with decreased risk of CHD (HR 0.51, 95 % CI 0.29–0.89) in women, it was significantly associated with increased risk of intracranial cerebral hemorrhage in all participants (HR 1.62, 95 % CI 1.04–2.53) and in men (HR 2.00, 95 % CI 1.04–3.83). In conclusion, isolated low HDL-C levels are not associated with increased risk of CHD in Japan. CHD risk may, therefore, be more strongly affected by serum total cholesterol levels in this population.

DOI： 10.1007/s10654-016-0203-1

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