研究者詳細 - 八谷　寛

論文 - 八谷　寛

分割表示 371 件中 61 - 80 件目／全件表示 >>

Risk and population attributable fraction of stroke subtypes in Japan 査読有り Open Access

Yatsuya, H; Yamagishi, K; Li, YY; Saito, I; Kokubo, Y; Muraki, I; Inoue, M; Tsugane, S; Iso, H; Sawada, N

JOURNAL OF EPIDEMIOLOGY 34 巻 ( 5 ) 頁： 211 - 217 2023年7月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: Associations of major risk factors for stroke with total and each type of stroke, as well as subtypes of ischemic stroke, and their population attributable fractions had not been examined comprehensively. Methods: Participants of the Japan Public Health Center-based prospective (JPHC) Study Cohort II without histories of cardiovascular disease and cancer (n = 14,797) were followed from 1993 through 2012. Associations of current smoking, hypertension, diabetes, overweight (body mass index ≥25 kg/m<sup>2</sup>), non-high-density lipoprotein cholesterol (non-HDLC) categories, low HDLC (<40 mg/dL), urine protein, and history of arrhythmia were examined in a mutually-adjusted Cox regression model that included age and sex. Population attributable fractions (PAFs) were estimated using the hazard ratios and the prevalence of risk factors among cases. Results: Subjects with hypertension were 1.63 to 1.84 times more likely to develop any type of stroke. Diabetes, low HDLC, current smoking, overweight, urine protein, and arrhythmia were associated with risk of overall and ischemic stroke. Hypertension and urine protein were associated with risk of intracerebral hemorrhage, while current smoking, hypertension, and low non-HDLC were associated with subarachnoid hemorrhage. Hypertension alone accounted for more than a quarter of stroke incidence, followed by current smoking and diabetes. High non-HDLC, current smoking, low HDLC, and overweight contributed mostly to large-artery occlusive stroke. Arrhythmia explained 13.2% of embolic stroke. Combined PAFs of all the modifiable risk factors for total, ischemic, and large-artery occlusive strokes were 36.7%, 44.5%, and 61.5%, respectively. Conclusion: Although there are differences according to subtypes, hypertension could be regarded as the most crucial target for preventing strokes in Japan.

DOI： 10.2188/jea.JE20220364

Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021 Open Access

Ong, KL; Stafford, LK; Mclaughlin, SA; Boyko, EJ; Vollset, SE; Smith, AE; Dalton, BE; Duprey, J; Cruz, JA; Hagins, H; Lindstedt, PA; Aali, A; Abate, YH; Abate, MD; Abbasian, M; Abbasi-Kangevari, Z; Abbasi-Kangevari, M; Abd ElHafeez, S; Abd-Rabu, R; Abdulah, DM; Abdullah, AM; Abedi, V; Abidi, H; Aboagye, RG; Abolhassani, H; Abu-Gharbieh, E; Abu-Zaid, A; Adane, TD; Adane, DE; Addo, IY; Adegboye, OA; Adekanmbi, V; Adepoju, AV; Adnani, QES; Afolabi, RF; Agarwal, G; Aghdam, ZB; Agudelo-Botero, M; Arriagada, CEA; Agyemang-Duah, W; Ahinkorah, BO; Ahmad, D; Ahmad, R; Ahmad, S; Ahmad, A; Ahmadi, A; Ahmadi, K; Ahmed, A; Ahmed, A; Ahmed, LA; Ahmed, SA; Ajami, M; Akinyemi, RO; Al Hamad, H; Hasan, SMA; AL-Ahdal, TMA; Alalwan, TA; Al-Aly, Z; Albataineh, M; Alcalde-Rabanal, JE; Alemi, S; Ali, H; Alinia, T; Aljunid, SM; Almustanyir, S; Al-Raddadi, RM; Alvis-Guzman, N; Amare, F; Ameyaw, EK; Amiri, S; Amusa, GA; Andrei, CL; Anjana, RM; Ansar, A; Ansari, G; Ansari-Moghaddam, A; Anyasodor, AE; Arabloo, J; Aravkin, AY; Areda, D; Arifin, H; Arkew, M; Armocida, B; Aernloev, J; Artamonov, AA; Arulappan, J; Aruleba, RT; Arumugam, A; Aryan, Z; Asemu, MT; Asghari-Jafarabadi, M; Askari, E; Asmelash, D; Astell-Burt, T; Athar, M; Athari, SS; Atout, MMW; Avila-Burgos, L; Awaisu, A; Azadnajafabad, S; Darshan, BB; Babamohamadi, H; Badar, M; Badawi, A; Badiye, A; Baghcheghi, N; Bagheri, N; Bagherieh, S; Bah, S; Bahadory, S; Bai, RH; Baig, AA; Baltatu, OC; Baradaran, HR; Barchitta, M; Bardhan, M; Barengo, NC; Baernighausen, TW; Barone, MTU; Barone-Adesi, F; Barrow, A; Bashiri, H; Basiru, A; Basu, S; Basu, S; Batiha, AMM; Batra, K; Bayih, MT; Bayileyegn, NS; Behnoush, AH; Bekele, AB; Belete, MA; Belgaumi, UI; Belo, L; Bennett, DA; Bensenor, IM; Berhe, K; Berhie, AY; Bhaskar, S; Bhat, AN; Bhatti, JS; Bikbov, B; Bilal, F; Bintoro, BS; Bitaraf, S; Bitra, VR; Bjegovic-Mikanovic, V; Bodolica, V; Boloor, A; Brauer, M; Brazo-Sayavera, J; Brenner, H; Butt, ZA; Calina, D; Campos, LA; Campos-Nonato, IR; Cao, Y; Cao, C; Car, J; Carvalho, M; Castaneda-Orjuela, CA; Catala-Lopez, F; Cerin, E; Chadwick, J; Chandrasekar, EK; Chanie, GS; Charan, J; Chattu, VK; Chauhan, K; Cheema, HA; Abebe, EC; Chen, SM; Cherbuin, N; Chichagi, F; Chidambaram, SB; Cho, WCS; Choudhari, SG; Chowdhury, R; Chowdhury, EK; Chu, DT; Chukwu, IS; Chung, SC; Coberly, K; Columbus, A; Contreras, D; Cousin, E; Criqui, MH; Cruz-Martins, N; Cuschieri, S; Dabo, B; Dadras, O; Dai, XC; Damasceno, AAM; Dandona, R; Dandona, L; Das, S; Dascalu, AM; Dash, NR; Dashti, M; Davila-Cervantes, CA; Cruz-Gongora, VD; Debele, GR; Delpasand, K; Demisse, FW; Demissie, GD; Deng, XL; Denova-Gutierrez, E; Deo, S; Dervisevic, E; Desai, HD; Desale, AT; Dessie, AM; Desta, F; Dewan, SMR; Dey, S; Dhama, K; Dhimal, M; Diao, NY; Diaz, D; Dinu, M; Diress, M; Djalalinia, S; Doan, LP; Dongarwar, D; Figueiredo, FWD; Duncan, BB; Dutta, S; Dziedzic, AM; Edinur, HA; Ekholuenetale, M; Ekundayo, TC; Elgendy, IY; Elhadi, M; El-Huneidi, W; Elmeligy, OAA; Elmonem, MA; Endeshaw, D; Esayas, HL; Eshetu, HB; Etaee, F; Fadhil, I; Fagbamigbe, AF; Fahim, A; Falahi, S; Faris, MEM; Farrokhpour, H; Farzadfar, F; Fatehizadeh, A; Fazli, G; Feng, XQ; Ferede, TY; Fischer, F; Flood, D; Forouhari, A; Foroumadi, R; Koudehi, MF; Gaidhane, AM; Gaihre, S; Gaipov, A; Galali, Y; Ganesan, B; Garcia-Gordillo, MA; Gautam, RK; Gebrehiwot, M; Gebrekidan, KG; Gebremeskel, TG; Getacher, L; Ghadirian, F; Ghamari, SH; Nour, MG; Ghassemi, F; Golechha, M; Goleij, P; Golinelli, D; Gopalani, SV; Guadie, HA; Guan, SY; Gudayu, TW; Guimaraes, RA; Guled, RA; Gupta, R; Gupta, K; Gupta, VB; Gupta, VK; Gyawali, B; Haddadi, R; Hadi, NR; Haile, TG; Hajibeygi, R; Haj-Mirzaian, A; Halwani, R; Hamidi, S; Hankey, GJ; Hannan, MA; Haque, S; Harandi, H; Harlianto, N; Hasan, SMM; Hasan, S; Hasani, H; Hassanipour, S; Hassen, MB; Haubold, J; Hayat, K; Heidari, G; Heidari, M; Hessami, K; Hiraike, Y; Holla, R; Hossain, S; Hossain, MS; Hosseini, MS; Hosseinzadeh, M; Hosseinzadeh, H; Huang, JJ; Huda, N; Hussain, S; Huynh, HH; Hwang, BF; Ibitoye, SE; Ikeda, N; Ilic, IM; Ilic, M; Inbaraj, LR; Iqbal, A; Islam, SMS; Islam, RM; Ismail, NE; Iso, H; Isola, G; Itumalla, R; Iwagami, M; Iwu, CCD; Iyamu, IO; Iyasu, AN; Jacob, L; Jafarzadeh, A; Jahrami, H; Jain, R; Jaja, C; Jamalpoor, Z; Jamshidi, E; Janakiraman, B; Jayanna, K; Jayapal, SK; Jayaram, S; Jayawardena, R; Jebai, R; Jeong, W; Jin, YZ; Jokar, M; Jonas, JB; Joseph, N; Joseph, A; Joshua, CE; Joukar, F; Jozwiak, JJ; Kaambwa, B; Kabir, A; Kabthymer, RH; Kadashetti, V; Kahe, F; Kalhor, R; Kandel, H; Karanth, S; Karaye, IM; Karkhah, S; Katoto, PD; Kaur, N; Kazemian, S; Kebede, SA; Khader, YS; Khajuria, H; Khalaji, A; AB Khan, M; Khan, M; Khan, A; Khanal, S; Khatatbeh, MM; Khater, AM; Khateri, S; Khorashadizadeh, F; Khubchandani, J; Kibret, BG; Kim, MS; Kimokoti, RW; Kisa, A; Kivimaki, M; Kolahi, AA; Komaki, S; Kompani, F; Koohestani, HR; Korzh, O; Kostev, K; Kothari, N; Koyanagi, A; Krishan, K; Krishnamoorthy, Y; Defo, BK; Kuddus, M; Kuddus, MA; Kumar, R; Kumar, H; Kundu, S; Kurniasari, MD; Kuttikkattu, A; La Vecchia, C; Lallukka, T; Larijani, B; Larsson, AO; Latief, K; Lawal, BK; Le, TTT; Le, TTB; Lee, SWH; Lee, M; Lee, WC; Lee, PH; Lee, SW; Lee, SW; Legesse, SM; Lenzi, J; Li, YZ; Li, MC; Lim, SS; Lim, LL; Liu, XF; Liu, CJ; Lo, CH; Lopes, G; Lorkowski, S; Lozano, R; Lucchetti, G; Maghazachi, AA; Mahasha, PW; Mahjoub, S; Mahmoud, MA; Mahmoudi, R; Mahmoudimanesh, M; Mai, AT; Majeed, A; Sanaye, PM; Makris, KC; Malhotra, K; Malik, AA; Malik, I; Mallhi, TH; Malta, DC; Mamun, AA; Mansouri, B; Marateb, HR; Mardi, P; Martini, S; Martorell, M; Marzo, RR; Masoudi, R; Masoudi, S; Mathews, E; Maugeri, A; Mazzaglia, G; Mekonnen, T; Meshkat, M; Mestrovic, T; Jonasson, JM; Miazgowski, T; Michalek, IM; Minh, LHN; Mini, GK; Miranda, JJ; Mirfakhraie, R; Mirrakhimov, EM; Mirza-Aghazadeh-Attari, M; Misganaw, A; Misgina, KH; Mishra, M; Moazen, B; Mohamed, NS; Mohammadi, E; Mohammadi, M; Mohammadian-Hafshejani, A; Mohammadshahi, M; Mohseni, A; Mojiri-Forushani, H; Mokdad, AH; Momtazmanesh, S; Monasta, L; Moniruzzaman, M; Mons, U; Montazeri, F; Ghalibaf, AM; Moradi, Y; Moradi, M; Sarabi, MM; Morovatdar, N; Morrison, SD; Morze, J; Mossialos, E; Mostafavi, E; Mueller, UO; Mulita, F; Mulita, A; Murillo-Zamora, E; Musa, KI; Mwita, JC; Nagaraju, SP; Naghavi, M; Nainu, F; Nair, TS; Najmuldeen, HHR; Nangia, V; Nargus, S; Naser, AY; Nassereldine, H; Natto, ZS; Nauman, J; Nayak, BP; Ndejjo, R; Negash, H; Negoi, RI; Nguyen, HTH; Nguyen, DH; Nguyen, PT; Nguyen, VT; Nguyen, HQ; Niazi, RK; Nigatu, YT; Ningrum, DNA; Nizam, MA; Nnyanzi, LA; Noreen, M; Noubiap, JJ; Nzoputam, OJ; Nzoputam, CI; Oancea, B; Odogwu, NM; Odukoya, OO; Ojha, VA; Okati-Aliabad, H; Okekunle, AP; Okonji, OC; Okwute, PG; Olufadewa, II; Onwujekwe, OE; Ordak, M; Ortiz, A; Osuagwu, UL; Oulhaj, A; Owolabi, MO; Padron-Monedero, A; Padubidri, JR; Palladino, R; Panagiotakos, D; Panda-Jonas, S; Pandey, A; Pandey, A; Pandi-Perumal, SR; Stoian, AMP; Pardhan, S; Parekh, T; Parekh, U; Pasovic, M; Patel, J; Patel, JR; Paudel, U; Pepito, VCF; Pereira, M; Perico, N; Perna, S; Petcu, IR; Petermann-Rocha, FE; Podder, V; Postma, MJ; Pourali, G; Pourtaheri, N; Prates, EJS; Qadir, MMF; Qattea, I; Raee, P; Rafique, I; Rahimi, M; Rahimifard, M; Rahimi-Movaghar, V; Rahman, MO; Rahman, MA; Rahman, MHU; Rahman, M; Rahman, MM; Rahmani, M; Rahmani, S; Rahmanian, V; Rahmawaty, S; Rahnavard, N; Rajbhandari, B; Ram, P; Ramazanu, S; Rana, J; Rancic, N; Ranjha, MMAN; Rao, CR; Rapaka, D; Rasali, DP; Rashedi, S; Rashedi, V; Rashid, AM; Rashidi, MM; Ratan, ZA; Rawaf, S; Rawal, L; Redwan, EMM; Remuzzi, G; Rengasamy, KRR; Renzaho, AMN; Reyes, LF; Rezaei, N; Rezaei, N; Rezaeian, M; Rezazadeh, H; Riahi, SM; Rias, YA; Riaz, M; Ribeiro, D; Rodrigues, M; Rodriguez, JAB; Roever, L; Rohloff, P; Roshandel, G; Roustazadeh, A; Rwegerera, GM; Saad, AMA; Saber-Ayad, MM; Sabour, S; Sabzmakan, L; Saddik, B; Sadeghi, E; Saeed, U; Moghaddam, SS; Safi, S; Safi, SZ; Saghazadeh, A; Sharif-Askari, NS; Sharif-Askari, FS; Sahebkar, A; Sahoo, SS; Sahoo, H; Saif-Ur-Rahman, KM; Sajid, MR; Salahi, S; Salahi, S; Saleh, MA; Salehi, MA; Salomon, JA; Sanabria, J; Sanjeev, RK; Sanmarchi, F; Santric-Milicevic, MM; Sarasmita, MA; Sargazi, S; Sathian, B; Sathish, T; Sawhney, M; Schlaich, MP; Schmidt, MI; Schuermans, A; Seidu, AA; Kumar, NS; Sepanlou, SG; Sethi, Y; Seylani, A; Shabany, M; Shafaghat, T; Shafeghat, M; Shafie, M; Shah, NS; Shahid, S; Shaikh, MA; Shanawaz, M; Shannawaz, M; Sharfaei, S; Shashamo, BB; Shiri, R; Shittu, A; Shivakumar, KM; Shivalli, S; Shobeiri, P; Shokri, F; Shuval, K; Sibhat, MM; Silva, LMLR; Simpson, CR; Singh, JA; Singh, P; Singh, S; Siraj, MS; Skryabina, AA; Sohag, AA; Soleimani, H; Solikhah, S; Soltani-Zangbar, MS; Somayaji, R; Sorensen, RJD; Starodubova, AV; Sujata, S; Suleman, M; Sun, J; Sundström, J; Tabares-Seisdedos, R; Tabatabaei, SM; Tabatabaeizadeh, SA; Tabish, M; Taheri, M; Taheri, E; Taki, E; Tamuzi, JJLL; Tan, KK; Tat, NY; Taye, BT; Temesgen, WA; Temsah, MH; Tesler, R; Thangaraju, P; Thankappan, KR; Thapa, R; Tharwat, S; Thomas, N; Ticoalu, JHV; Tiyuri, A; Tonelli, M; Tovani-Palone, MR; Trico, D; Trihandini, I; Tripathy, JP; Tromans, SJ; Tsegay, GM; Tualeka, AR; Tufa, DG; Tyrovolas, S; Ullah, S; Upadhyay, E; Vahabi, SM; Vaithinathan, AG; Valizadeh, R; van Daalen, KR; Vart, P; Varthya, SB; Vasankari, TJ; Vaziri, S; Verma, MV; Verras, GI; Vo, DC; Wagaye, B; Waheed, Y; Wang, ZY; Wang, YQ; Wang, C; Wang, F; Wassie, GT; Wei, MYW; Weldemariam, AH; Westerman, R; Wickramasinghe, ND; Wu, YF; Wulandari, RDWI; Xia, J; Xiao, H; Xu, SW; Xu, XY; Yada, DY; Yang, L; Yatsuya, H; Yesiltepe, M; Yi, SY; Yohannis, HK; Yonemoto, N; You, YY; Bin Zaman, S; Zamora, N; Zare, I; Zarea, K; Zarrintan, A; Zastrozhin, MS; Zeru, NG; Zhang, ZJ; Zhong, CW; Zhou, JJ; Zielinska, M; Zikarg, YT; Zodpey, S; Zoladl, M; Zou, ZY; Zumla, A; Zuniga, YMH; Magliano, DJ; Murray, CJL; Hay, SI; Vos, T

LANCET 402 巻 ( 10397 ) 頁： 203 - 234 2023年7月

掲載種別：研究論文（学術雑誌）出版者・発行元：Lancet

Background: Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of type 1 and type 2 diabetes in 2021, the proportion of the type 2 diabetes burden attributable to selected risk factors, and projections of diabetes prevalence through 2050. Methods: Estimates of diabetes prevalence and burden were computed in 204 countries and territories, across 25 age groups, for males and females separately and combined; these estimates comprised lost years of healthy life, measured in disability-adjusted life-years (DALYs; defined as the sum of years of life lost [YLLs] and years lived with disability [YLDs]). We used the Cause of Death Ensemble model (CODEm) approach to estimate deaths due to diabetes, incorporating 25 666 location-years of data from vital registration and verbal autopsy reports in separate total (including both type 1 and type 2 diabetes) and type-specific models. Other forms of diabetes, including gestational and monogenic diabetes, were not explicitly modelled. Total and type 1 diabetes prevalence was estimated by use of a Bayesian meta-regression modelling tool, DisMod-MR 2.1, to analyse 1527 location-years of data from the scientific literature, survey microdata, and insurance claims; type 2 diabetes estimates were computed by subtracting type 1 diabetes from total estimates. Mortality and prevalence estimates, along with standard life expectancy and disability weights, were used to calculate YLLs, YLDs, and DALYs. When appropriate, we extrapolated estimates to a hypothetical population with a standardised age structure to allow comparison in populations with different age structures. We used the comparative risk assessment framework to estimate the risk-attributable type 2 diabetes burden for 16 risk factors falling under risk categories including environmental and occupational factors, tobacco use, high alcohol use, high body-mass index (BMI), dietary factors, and low physical activity. Using a regression framework, we forecast type 1 and type 2 diabetes prevalence through 2050 with Socio-demographic Index (SDI) and high BMI as predictors, respectively. Findings: In 2021, there were 529 million (95% uncertainty interval [UI] 500–564) people living with diabetes worldwide, and the global age-standardised total diabetes prevalence was 6·1% (5·8–6·5). At the super-region level, the highest age-standardised rates were observed in north Africa and the Middle East (9·3% [8·7–9·9]) and, at the regional level, in Oceania (12·3% [11·5–13·0]). Nationally, Qatar had the world's highest age-specific prevalence of diabetes, at 76·1% (73·1–79·5) in individuals aged 75–79 years. Total diabetes prevalence—especially among older adults—primarily reflects type 2 diabetes, which in 2021 accounted for 96·0% (95·1–96·8) of diabetes cases and 95·4% (94·9–95·9) of diabetes DALYs worldwide. In 2021, 52·2% (25·5–71·8) of global type 2 diabetes DALYs were attributable to high BMI. The contribution of high BMI to type 2 diabetes DALYs rose by 24·3% (18·5–30·4) worldwide between 1990 and 2021. By 2050, more than 1·31 billion (1·22–1·39) people are projected to have diabetes, with expected age-standardised total diabetes prevalence rates greater than 10% in two super-regions: 16·8% (16·1–17·6) in north Africa and the Middle East and 11·3% (10·8–11·9) in Latin America and Caribbean. By 2050, 89 (43·6%) of 204 countries and territories will have an age-standardised rate greater than 10%. Interpretation: Diabetes remains a substantial public health issue. Type 2 diabetes, which makes up the bulk of diabetes cases, is largely preventable and, in some cases, potentially reversible if identified and managed early in the disease course. However, all evidence indicates that diabetes prevalence is increasing worldwide, primarily due to a rise in obesity caused by multiple factors. Preventing and controlling type 2 diabetes remains an ongoing challenge. It is essential to better understand disparities in risk factor profiles and diabetes burden across populations, to inform strategies to successfully control diabetes risk factors within the context of multiple and complex drivers. Funding: Bill & Melinda Gates Foundation.

DOI： 10.1016/S0140-6736(23)01301-6

Work and Family Conflicts, Depression, and "Ikigai": A Mediation Analysis in a Cross-cultural Study Between Japanese and Egyptian Civil Workers 国際共著 Open Access

Eshak, ES; Baba, S; Yatsuya, H; Iso, H; Hirakawa, Y; Mahfouz, EM; Chifa, C; Sakaniwa, R; El-khateeb, AS

JOURNAL OF EPIDEMIOLOGY 33 巻 ( 7 ) 頁： 360 - 366 2023年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: Total work-family conflicts (TWFCs) could associate with mental health, and having ikigai (a purpose of life) may mediate this association. Methods: In a cross-cultural study of 4,792 Japanese Aichi Workers’ Cohort study participants and 3,109 Egyptian civil workers, the Midlife Development in the United States (MIDUS) questionnaire measured TWFCs and the Center for Epidemiological Studies Depression (CES-D) 11-item scale measured depression. We used logistic regression models to estimate odds ratios (ORs) of having depression and a high-ikigai across levels of TWFCs (low, moderate, and high), and the PROCESS macro of Hayes to test the mediation effect. Results: The prevalence of high TWFCs, depression, and having a high ikigai were 17.9%, 39.4%, and 70.1% in Japanese women, 10.5%, 26.8%, and 70.1% in Japanese men, 23.7%, 58.2%, and 24.7% in Egyptian women, and 19.1%, 38.9%, and 36.9% in Egyptian men, respectively. Compared with participants with low TWFCs, the multivariable ORs of depression in Japanese women and men with high TWFCs were 4.11 (95% confidence interval [CI], 2.99–5.65) and 5.42 (95% CI, 4.18–7.02), and those in Egyptian women and men were 4.43 (95% CI, 3.30–5.95) and 4.79 (95% CI, 3.53–6.48), respectively. The respective ORs of having a high-ikigai were 0.46 (95% CI, 0.33–0.64) and 0.40 (95% CI, 0.31–0.52) in Japanese women and men and were 0.34 (95% CI, 0.24–0.48) and 0.28 (95% CI, 0.20–0.39) in Egyptian women and men. No interaction between TWFCs and country was observed for the associations with depression or ikigai. Ikigai mediated (up to 18%) the associations between the TWFCs and depression, especially in Egyptian civil workers. Conclusion: TWFCs were associated with depression, and having low ikigai mediated these associations in Japanese and Egyptian civil workers.

DOI： 10.2188/jea.JE20210338

Impact of combined resection of the internal iliac artery on loss of volume of the gluteus muscles after pelvic exenteration 査読有り

Murata, Y; Uehara, K; Ogura, A; Ishigaki, S; Aiba, T; Mizuno, T; Kokuryo, T; Yokoyama, Y; Yatsuya, H; Ebata, T

SURGERY TODAY 53 巻 ( 7 ) 頁： 791 - 799 2023年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Surgery Today

Purpose: To clarify the influence of additional internal iliac artery (IIA) resection on the loss of the gluteus muscle volume after pelvic exenteration (PE). Methods: The subjects of this retrospective analysis were 78 patients who underwent PE with or without IIA resection (n = 44 and n = 34, respectively) between 2006 and 2018. The areas of gluteal muscles (GMs) and psoas muscles (PSMs) were calculated using CT images before and 6 months after PE, and the difference was compared. Results: The volumes of the GMs and PSMs were significantly reduced after PE (P < 0.001 and P = 0.005, respectively). In the IIA resection group, the GMs were significantly reduced after surgery, but the PSMs were not. The maximum GM (Gmax) was the most atrophied among the GMs. Multivariable analysis revealed that complete IIA resection was an independent promotor of the loss of volume of the Gmax (P = 0.044). In 18 patients with unilateral IIA resection, the downsizing rate of the Gmax was significantly greater on the resected side than on the non-resected side (P = 0.008). Conclusions: The GMs and PSMs were significantly smaller after PE. Complete IIA resection reduced the Gmax area remarkably. Preservation of the superior gluteus artery is likely to help maintain Gmax size, suggesting a potential preventative measure against secondary sarcopenia.

DOI： 10.1007/s00595-022-02635-z

Predictive Value of Long-Term Systolic Blood Pressure Variability for the Development of Type 2 Diabetes Mellitus 査読有り

Yatsuya, H; Song, ZA; Hong, YJ; Mamun, R; Yoshida, Y; Akter, T; Nuamah, G; Tajima, R; Lin, JY; Al-Shoaibi, A; Chiang, C; Nakano, Y; Li, YY; Matsunaga, M; Ota, A; Tamakoshi, K

CIRCULATION 147 巻 2023年2月

Relationship Between Fasting Blood Glucose Levels in Middle Age and Cognitive Function in Later Life: The Aichi Workers' Cohort Study Open Access

Shimoda, M; Kaneko, K; Nakagawa, T; Kawano, N; Otsuka, R; Ota, A; Naito, H; Matsunaga, M; Ichino, N; Yamada, H; Chiang, CF; Hirakawa, Y; Tamakoshi, K; Aoyama, A; Yatsuya, H

JOURNAL OF EPIDEMIOLOGY 33 巻 ( 2 ) 頁： 76 - 81 2023年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: There is limited evidence regarding the relationship between Diabetes mellitus (DM) in middle age and mild cognitive impairment after a follow-up. Therefore, we investigated the relationship between fasting blood glucose (FBG) levels in middle age and cognitive function assessed using the Japanese version of the Montreal Cognitive Assessment (MoCA-J) in later life, following over 15 years of follow-up in the Aichi Workers’ Cohort Study in Japan. Methods: Participants were 253 former local government employees aged 60–79 years in 2018 who participated in a baseline survey conducted in 2002. Using baseline FBG levels and self-reported history, participants were classified into the normal, impaired fasting glucose (IFG) and, and DM groups. Total MoCA-J score ranges from 0 to 30, and cognitive impairment was defined as MoCA-J score ≤25 in this study. A general linear model was used to estimate the mean MoCA-J scores in the FBG groups, adjusted for age, sex, educational year, smoking status, alcohol consumption, physical activity, body mass index, systolic blood pressure, total cholesterol, and estimated glomerular filtration rate. Results: The mean MoCA-J score in the total population was 25.0, and the prevalence of MoCA-J score ≤25 was 49.0%. Multivariable-adjusted total MoCA-J scores were 25.2, 24.8, and 23.4 in the normal, IFG, and DM groups, respectively. The odds ratio of MoCA-J score ≤25 in the DM group was 3.29. Conclusion: FBG level in middle age was negatively associated with total MoCA-J scores assessed later in life, independent of confounding variables.

DOI： 10.2188/jea.JE20210128

Secondhand smoke and the risk of incident cardiovascular disease among never-smoking women (vol 162, 107145, 2022) 査読有り国際誌

Kobayashi, Y; Yamagishi, K; Muraki, I; Kokubo, Y; Saito, I; Yatsuya, H; Iso, H; Tsugane, S; Sawada, N

PREVENTIVE MEDICINE 167 巻頁： 107396 - 107396 2023年2月

The Association Between Adult Height and Stroke Incidence in Japanese Men and Women: A Population-based Case-Control Study Open Access

Kondo, Y; Yatsuya, H; Ota, A; Matsumoto, S; Ueda, A; Watanabe, H; Toyoshima, H

JOURNAL OF EPIDEMIOLOGY 33 巻 ( 1 ) 頁： 23 - 30 2023年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: No studies have examined the associations between adult height and ischemic stroke subtypes. Methods: We conducted a population-based case-control study that included 2,451 thrombotic and 687 embolic stroke cases, as well as 1,623 intracerebral and 768 subarachnoid hemorrhage cases without history of stroke aged 40–79 years, and the same number of sex-and age-matched controls. Cases and controls were grouped according to the quintile cut-off values of height in controls, and the third quintile, which was approximately the average height group, was used as the reference group. Height divided by one standard deviation of height in controls was also examined as a continuous variable. The analyses were carried out separately for participants aged 40–59 years and 60–79 years. Results: In both younger and older men, height was linearly inversely associated with total and thrombotic strokes, and the shortest quintile compared to the reference group was associated with increased risks of these strokes. Although height was linearly inversely associated with embolic stroke and intracerebral hemorrhage in younger men, the shortest quintile did not show increased risks of these strokes. Height did not seem to be associated with total stroke and any stroke subtypes in younger women. In contrast, the tallest quintile was significantly associated with increased risks of total stroke and intracerebral hemorrhage, and height tended to be positively associated with these strokes in older women. Conclusion: We reported the associations between adult height and ischemic stroke subtypes for the first time, which differed according to sex and age group.

DOI： 10.2188/jea.JE20200531

Including measures of chronic kidney disease to improve cardiovascular risk prediction by SCORE2 and SCORE2-OP 査読有り国際共著国際誌 Open Access

Matsushita, K; Kaptoge, S; Hageman, SHJ; Sang, YY; Ballew, SH; Grams, ME; Surapaneni, A; Sun, LL; Arnlov, J; Bozic, M; Brenner, H; Brunskill, NJ; Chang, AR; Chinnadurai, R; Cirillo, M; Correa, A; Ebert, N; Eckardt, KU; Gansevoort, RT; Gutierrez, O; Hadaegh, F; He, J; Hwang, SJ; Jafar, TH; Jassal, SK; Kayama, T; Kovesdy, CP; Landman, GW; Levey, AS; Lloyd-Jones, DM; Major, RW; Miura, K; Muntner, P; Nadkarni, GN; Nowak, C; Ohkubo, T; Pena, MJ; Polkinghorne, KR; Sairenchi, T; Schaeffner, E; Schneider, MP; Shalev, V; Shlipak, MG; Solbu, MD; Stempniewicz, N; Tollitt, J; Valdivielso, JM; van der Leeuw, J; Wang, AYM; Wen, CP; Woodward, M; Yamagishi, K; Yatsuya, H; Zhang, LX; Dorresteijn, JAN; Di Angelantonio, E; Visseren, FLJ; Pennells, L; Coresh, J

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY 30 巻 ( 1 ) 頁： 8 - 16 2023年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：European Journal of Preventive Cardiology

Aims: The 2021 European Society of Cardiology (ESC) guideline on cardiovascular disease (CVD) prevention categorizes moderate and severe chronic kidney disease (CKD) as high and very-high CVD risk status regardless of other factors like age and does not include estimated glomerular filtration rate (eGFR) and albuminuria in its algorithms, systemic coronary risk estimation 2 (SCORE2) and systemic coronary risk estimation 2 in older persons (SCORE2-OP), to predict CVD risk. We developed and validated an 'Add-on' to incorporate CKD measures into these algorithms, using a validated approach. Methods: In 3,054 840 participants from 34 datasets, we developed three Add-ons [eGFR only, eGFR + urinary albumin-to-creatinine ratio (ACR) (the primary Add-on), and eGFR + dipstick proteinuria] for SCORE2 and SCORE2-OP. We validated C-statistics and net reclassification improvement (NRI), accounting for competing risk of non-CVD death, in 5,997 719 participants from 34 different datasets. Results: In the target population of SCORE2 and SCORE2-OP without diabetes, the CKD Add-on (eGFR only) and CKD Add-on (eGFR + ACR) improved C-statistic by 0.006 (95%CI 0.004-0.008) and 0.016 (0.010-0.023), respectively, for SCORE2 and 0.012 (0.009-0.015) and 0.024 (0.014-0.035), respectively, for SCORE2-OP. Similar results were seen when we included individuals with diabetes and tested the CKD Add-on (eGFR + dipstick). In 57 485 European participants with CKD, SCORE2 or SCORE2-OP with a CKD Add-on showed a significant NRI [e.g. 0.100 (0.062-0.138) for SCORE2] compared to the qualitative approach in the ESC guideline. Conclusion: Our Add-ons with CKD measures improved CVD risk prediction beyond SCORE2 and SCORE2-OP. This approach will help clinicians and patients with CKD refine risk prediction and further personalize preventive therapies for CVD.

DOI： 10.1093/eurjpc/zwac176

MEASURES OF LONG-TERM SYSTOLIC BLOOD PRESSURE VARIABILITY AND THEIR ASSOCIATIONS WITH THE RISK OF INCIDENT TYPE 2 DIABETES MELLITUS

Song, ZA; He, YP; Chiang, CF; Alshoaibi, AAA; Rahman, KMSU; Mamun, MR; Aoyama, A; Hirakawa, Y; Matsunaga, M; Ota, A; Tamakoshi, K; Li, YY; Yatsuya, H

JOURNAL OF HYPERTENSION 41 巻頁： E134 - E134 2023年1月

Association of Low-Density Lipoprotein Cholesterol with Risk of Coronary Heart Disease and Stroke among Middle-Aged Japanese Workers: An Analysis using Inverse Probability Weighting 査読有り国際共著 Open Access

Al-Shoaibi, AAA; Li, YY; Song, Z; Chiang, CF; Hirakawa, Y; Saif-Ur-Rahman, KM; Shimoda, M; Nakano, Y; Matsunaga, M; Aoyama, A; Tamakoshi, K; Ota, A; Yatsuya, H

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 30 巻 ( 5 ) 頁： 455 - 466 2023年

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Atherosclerosis and Thrombosis

Aims: The associations between low-density lipoprotein cholesterol (LDL-C) and the risk of cardiovascular disease (CVD) subtypes are not well established among the Japanese population. This study used longitudinal data from the Aichi Workers’ Cohort Study to explore the association between LDL-C levels and the risk of coronary heart disease (CHD) and stroke subtypes. Methods: Pooled data of 8966 adults (7093men and 1903 women) who were recruited between (2002) and (2008) were used for the current analysis. Propensity scores for the LDL-C categories were generated using multinomial logistic regression. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from the inverse probability weighted Cox proportional hazards model for LDL-C category associations with risks of CHD, stroke subtypes, and CVD. Results: During a median follow-up of 12 years, 122 strokes (57 ischemic strokes, 25 intracerebral hemorrhage, and 40 unknown subtypes) and 82 cases of CHD were observed. LDL-C 160– mg/dL compared to LDL-C 100– 119 mg/dL was positively and significantly associated with the risk of CHD (HR: 4.56; 95% CI: 1.91–10.9) but not with ischemic stroke (HR: 0.99; 95% CI: 0.44–2.22). LDL-C was inversely associated with the risk of intracerebral hemorrhage (P for trend=0.009). Conclusion: In middle-aged Japanese workers, LDL-C was significantly and positively associated with CHD, but not with ischemic stroke. LDL-C was inversely significantly associated with intracerebral hemorrhage.

DOI： 10.5551/jat.63519

Sociodemographic and behavioral factors related to obesity among adults in the Republic of Palau based on the WHO STEPwise approach to NCD risk factor surveillance 2011-2013: A cross-sectional study 査読有り国際共著 Open Access

Hasegawa, M; Honjo, K; Chiang, CF; Mita, T; Watson, BM; Ikerdeu, E; Madraisau, S; Yatsuya, H; Aoyama, A; Iso, H

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE 28 巻 ( 0 ) 頁： 39 - 39 2023年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Environmental Health and Preventive Medicine

Background: Pacific islanders face drastic increase of obesity-related noncommunicable disease (NCD) due to lifestyle shifts of unhealthy diets and physical inactivity. To date, however, obesity related factors have not been well elucidated in Republic of Palau. This study aimed to investigate sociodemographic and behavioral factors related to obesity using the national level data in Palau. Methods: This is a cross-sectional, population-based study analyzing random sampling data of 2133 adults aged 25–64 years (of 20 thousand national population) from the WHO STEPwise approach to NCD risk factor surveillance (STEPS) implemented between 2011 and 2013. Sociodemographic and behavioral factors were obtained by the STEPS standardized questionnaire for NCD risk factors plus the question on betel nut chewing because of its common behavior in Micronesian countries. Logistic regression analysis was performed to estimate multivariable odds ratio (OR) of general obesity (body mass index ≥30.0 kg/m<sup>2</sup>) and central obesity (waist circumference ≥90 cm in men and ≥80 cm in women). Results: Means of body mass index, prevalence of general obesity and central obesity were higher in women (29.9 kg/m<sup>2</sup>, 45.5% and 85.4%) than in men (29.3 kg/m<sup>2</sup>, 40.4% and 67.6%). After adjusted by other potential factors, native Palauan (OR 4.4, 95% CI, 2.7–7.0 for men and 3.6, 2.3–5.6 for women), betel nut chewing (1.5, 1.1–2.1 for men and 1.6, 1.2–2.3 for women), men who work at government office (1.6, 1.2–2.1), women with higher household income (1.4, 1.0–1.8) were positively associated with general obesity, while frequent vegetable intake were inversely associated with it among women (0.71, 0.54–0.93). Similar associations were observed between the aforementioned factors and central obesity. Conclusions: Native Palauan, people with betel nut chewing behavior, government employment and higher income appeared to be associated with obesity, while frequent vegetable consumption were inversely associated with obesity. Further interventions for prevention and control of obesity are necessary through the enhancing public relation activities to understand harmful health effects on betel nuts chewing and recommending domestic production of vegetables.

DOI： 10.1265/ehpm.22-00309

Renal Dysfunction after Rectal Cancer Surgery: A Long-term Observational Study Open Access

Sando, M; Uehara, K; Li, YY; Ogura, A; Murata, Y; Mizuno, T; Yatsuya, H; Ebata, T

JOURNAL OF THE ANUS RECTUM AND COLON 7 巻 ( 3 ) 頁： 176 - 185 2023年

記述言語：英語出版者・発行元：Journal of the Anus Rectum and Colon

Objectives: Despite the high incidence of urinary dysfunction (UD) after rectal surgery, it remains questionable whether UD causes future chronic kidney disease (CKD). This study aimed to clarify the long-term trends in renal function and risk factors for future CKD after rectal resection. Methods: For comparison, patients who underwent rectal resection (n = 129) and colectomy (n = 127) between 2006 and 2017 were identified. The estimated glomerular filtration rate (eGFR) ratio was calculated as the ratio to the baseline. “eGFR ratio < 0.75 at 3-year” was adopted as a surrogate indicator of future CKD. Results: eGFR ratio significantly decreased in the rectal cohort compared with the colon cohort at 1.5 years (0.9 vs. 0.95, p = 0.008) and at 3 years (0.85 vs. 0.94, p < 0.001). Although the preoperative prevalence of CKD was lower in the rectal than the colon cohort (13.9% vs. 23.6%, p = 0.055), it was similar at 3 years (29.5% vs. 30.7%). In multivariate analysis, females, and cT4 were independent risk factors for future CKD, but UD itself was not. Conclusions: Postoperative eGFR significantly decreased after rectal cancer surgery compared to colectomy. The prevalence of CKD more than doubled at 3 years after rectal resection. The female sex and cT4 tumor, instead of the UD, were independent risk factors for future CKD.

DOI： 10.23922/jarc.2022-059

Increasing Role of Overweight/Obesity as the Determinant of Hypertension and the Consequent Cardiovascular Diseases in Japan Open Access

Yatsuya, H

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 30 巻 ( 4 ) 頁： 323 - 325 2023年

Psychological Distress During the Coronavirus Disease 2019 Pandemic and Associated Factors Among Undergraduate Students in Japan 査読有り Open Access

Sato, Y; Yatsuya, H; Saijo, Y; Yoshioka, E; Tabuchi, T

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS 17 巻 ( 12 ) 頁： e294 2022年12月

記述言語：英語出版者・発行元：Disaster Medicine and Public Health Preparedness

Objective: This cross-sectional study aimed to examine factors potentially associated with psychological distress among undergraduate students during the coronavirus disease 2019 pandemic in Japan. Methods: We analyzed data of 958 undergraduates (median age 20 y; 56.8% women) from a Web-based, self-administered questionnaire survey conducted from August to September 2020. Prevalence ratios (PRs) for psychological distress defined as 5 points or over of the Kessler Psychological Distress Scale (K6) were calculated by Poisson regression models. Results: The proportion of psychological distress was 40.0%. In the mutually-adjusted model, the following were significantly associated with psychological distress: decreases in household income to 50-99% of the prepandemic amount compared with no change (PR = 1.48), newly experiencing unpaid wages compared with no experience (PR = 1.44), insufficient money to buy necessities compared with no shortage (PR = 1.45), receiving a student loan or scholarship compared with none (PR = 1.27), and communication 1 to 3 times a month compared with at least once a week (PR = 1.22). In contrast, school closure during the pandemic compared with no closure was inversely associated with psychological distress (PR = 0.78). Conclusions: Among undergraduate students in Japan, economic difficulties significantly predicted psychological distress.

DOI： 10.1017/dmp.2022.245

Possible contribution of COVID-19 vaccination to the subsequent mental well-being in Japan 査読有り国際誌 Open Access

Chiang, CF; Morita, S; Hirakawa, Y; Priya, FT; Matsumoto, Y; Ota, A; Yatsuya, H; Tabuchi, T

SCIENTIFIC REPORTS 12 巻 ( 1 ) 頁： 21195 - 21195 2022年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

The coronavirus disease 2019 (COVID-19) pandemic has had a severe impact on mental well-being. Vaccination may have played a pivotal role in enduring this mental health crisis. The present study aimed to longitudinally investigate the association between COVID-19 vaccination and mental health status among Japanese population in 2021. Longitudinal data of 17,089 individuals aged 15–79 years who participated in a nationwide online study were analyzed. Baseline and follow-up mental health statuses were assessed using the Kessler Psychological Distress Scale (K6). General linear and multivariable logistic regression models adjusted for baseline levels of mental distress were used to examine the association between vaccine receipt and follow-up levels of mental health. Mean K6 scores were lower in the vaccinated than in the non-vaccinated participants. Those who had received one or two doses of COVID-19 vaccines were associated with improved mental health at follow-up in subjects with psychological distress at baseline (odds ratio [OR] 1.31 and 1.35, respectively) and were inversely associated with deteriorated mental health status at follow-up in subjects without psychological distress at baseline (OR 0.66 and 0.70, respectively) compared with no vaccination groups, respectively. The present study would indicate that one or two doses of COVID-19 vaccinations contributed to mental well-being in Japan. This finding might provide evidence for promoting vaccination against COVID-19 and emerging infectious diseases in the future.

DOI： 10.1038/s41598-022-25357-1

Super-additive associations between parity and education level on mortality from cardiovascular disease and other causes: the Japan Collaborative Cohort Study 査読有り国際誌 Open Access

Yasukawa S., Eguchi E., Tamakoshi A., Iso H., Tamakoshi A., Mori M., Kaneko Y., Tsuji I., Nakamura Y., Yamagishi K., Mikami H., Kurosawa M., Hoshiyama Y., Tanabe N., Tamakoshi K., Wakai K., Ando M., Suzuki K., Hashimoto S., Yatsuya H., Kikuchi S., Wada Y., Okabayashi S., Ozasa K., Mikami K., Sakata K., Kurozawa Y., Fujino Y.

BMC Women S Health 22 巻 ( 1 ) 2022年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMC Women S Health

Background: While women’s parity status and education level have independent associations with cardiovascular and other diseases, no studies have evaluated the additive interaction of these two factors. Therefore, we examined the additive interaction between parity and education level on mortality from stroke, coronary heart disease, total cardiovascular disease, cancer, non-cardiovascular disease, and non-cancer causes, and all causes in Japanese women. Methods: This study followed 41,242 women aged 40–79 years without a history of cardiovascular disease or cancer from 1988 to 1990 until 2009. Baseline parity and education level were classified into four categories, with highly educated parous women as the reference group. Cox proportional hazards regression analyses were performed to calculate the risk of mortality. We also assessed the additive interactions between parity and education level on mortality from cardiovascular disease and other causes using the relative excess risk due to interaction obtained using Cox models. Results: During the median follow-up period of 19.1 years, we identified 6299 deaths. In a multivariable model adjusted for cardiovascular disease and other disease risk factors, nulliparous women with low education levels had increased multivariable-adjusted hazard ratios of 1.67 (95% confidence interval [CI] 1.13, 2.47) for stroke, 1.98 (95% CI 1.15, 3.39) for coronary heart disease, 1.71 (95% CI 1.34,2.18) for total cardiovascular disease, 1.69 (95% CI 1.33, 2.14) for non-cardiovascular and non-cancer, and 1.51 (95% CI 1.30, 1.75) for all-cause mortality when compared with highly educated parous women. Moreover, we observed significant additive interactions between parity and education level on total cardiovascular disease mortality (P = 0.04), non-cardiovascular disease and non-cancer mortality (P = 0.01), and all-cause mortality (P = 0.005). Conclusions: Nulliparity and low education levels are super-additively associated with total cardiovascular disease, non-cardiovascular and non-cancer, and all-cause mortality risks, suggesting that nulliparous women with low education levels need specific support for preventing mortality related to cardiovascular and other diseases.

DOI： 10.1186/s12905-022-01805-y

The association of public trust with the utilization of digital contact tracing for COVID-19 in Japan 査読有り国際誌 Open Access

He, YP; Yatsuya, H; Ota, A; Tabuchi, T

PUBLIC HEALTH IN PRACTICE 4 巻頁： 100279 - 100279 2022年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Public Health in Practice

Objectives: To examin whether public trust was associated with the utilization of COVID-19 Contact Confirming Application (COCOA) in those who self-reported a history of COVID-19. Study design: Cross-sectional study. Methods: Data were obtained from the Japan Society and New Tobacco Internet Survey, a nationwide online survey conducted from February to March 2021, which also assessed items related to COVID-19 and public trust. We included 453 participants with a history of COVID-19. Participants' reports of their general trust in the national government and the related policies, attitudes toward COVID-19 vaccination, and the adherence to the preventive measures against SARS-CoV-2 spread were compared between COCOA users and non-users controlling for age, sex, and socioeconomic statuses by analysis of covariance. Mediation analysis was conducted to examine whether public trust mediates the associations of certain participants’ characteristics with COCOA utilization. Results: Seventy-six percent (344/453) reported the COCOA utilization. Compared to non-users, the users were younger, more likely to be men and had a tendency to have higher education. They were more willing to get COVID-19 vaccination, adherent to public health measures against the spread of the SARS-Cov-2, and more likely to express trust in government in general and policies related to COVID-19 independent of age, sex, and the socioeconomic status. Trust in government did not mediate the associations of age and education with COCOA utilization. Conclusions: The utilization of digital contact tracing technology for the health of public during pandemic was related to the degree of trust in the government in Japan.

DOI： 10.1016/j.puhip.2022.100279

Gender Difference in Fear and Anxiety about and Perceived Susceptibility to COVID-19 in the Third Wave of Pandemic among the Japanese General Population: A Nationwide Web-Based Cross-Sectional Survey 査読有り国際誌 Open Access

Sasaki, R; Ota, A; Yatsuya, H; Tabuchi, T

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 19 巻 ( 23 ) 2022年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Environmental Research and Public Health

Existing research suggested gender differences in fear and anxiety about and perceived susceptibility to COVID-19 and previous infectious disease pandemics. We analyzed whether women felt fear and anxiety about and perceived susceptibility to COVID-19 more frequently than men in Japan. We conducted a cross-sectional analysis using internet survey data collected during the third wave of the pandemic in Japan. The subjects were enrolled from the Japanese general population: 11,957 men and 11,559 women. Fear and anxiety specifically related to COVID-19 were evaluated with the Japanese version of the Fear of COVID-19 Scale (FoCS). The question “How likely do you think you will be infected with COVID-19?” was used to assess the perceived susceptibility to COVID-19. Women had higher mean (standard deviation) FoCS scores [18.6 (5.6) vs. 17.5 (5.9), d = 0.190] and reported the median or higher FoCS score (57.4% vs. 51.4%, φ = 0.060) and perceived susceptibility (13.6% vs. 11.5%, φ = 0.032) more frequently than men. The odds ratios (95% confidence intervals) adjusted for age, having a spouse, comorbidities, watching commercial TV stations’ news programs, employment status, and household income were 1.24 (1.17–1.32) and 1.27 (1.16–1.38), respectively. We observed that women were more anxious and fearful about and perceived the susceptibility to infectious diseases more frequently than men even one year after the pandemic occurred in Japan, although the effect size was small.

DOI： 10.3390/ijerph192316239

Association between long-term alcohol consumption and insomnia symptoms in civil servants: Aichi Workers' Cohort Study. 査読有り

Terabe M, Kitajima T, Ota A, Yatsuya H, Iwata N

Fujita medical journal 8 巻 ( 4 ) 頁： 103 - 107 2022年11月

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