論文 - 八谷　寛

Endoscopic sphincterotomy and endoscopic biliary stenting do not affect the sensitivity of transpapillary forceps biopsy for the diagnosis of bile duct adenocarcinoma 査読有り 国際誌

Aoki, T; Ohno, E; Ishikawa, T; Mizutani, Y; Iida, T; Yamao, K; Yamamura, T; Furukawa, K; Nakamura, M; Honda, T; Ishigami, M; Yatsuya, H; Kawashima, H

BMC GASTROENTEROLOGY   22 巻 ( 1 ) 頁： 329   2022年7月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：BMC Gastroenterology  

Background: The pathological evaluation of tissues with cholangitis is considered difficult, which can often occur after endoscopic sphincterotomy (EST) and endoscopic biliary stenting (EBS). This study aimed to evaluate the influence of a history of EST and EBS on the sensitivity of transpapillary forceps bile duct biopsy (TB) for bile duct adenocarcinoma. Methods: This retrospective study included consecutive cases of bile duct adenocarcinoma in which TB was performed before July 2020 until the number exceeded that required to support statistical and noninferiority analyses of the sensitivity of TB between patients with and without each variable. The incidence of postprocedural adverse events related to each factor was also investigated. Results: Overall, 280 samples were required in each group, and 437 subjects (792 samples) were included. The sensitivity of TB was 63.6% for the subjects and 59.6% for the biopsy samples. For the biopsy samples, the sensitivity did not differ significantly between samples from patients with and without a history of EST (59.1% vs. 58.9%, P = 0.952) and EBS (62.1% vs. 55.4%, P = 0.065). The sensitivity was significantly higher for samples from patients with jaundice (67.9% vs. 57.0%, P = 0.008). There were significantly fewer procedure-related adverse events in patients with a history of EST (10.8% vs. 19.0%, P = 0.017) and EBS (12.0% vs. 21.7%, P = 0.005). Conclusions: A history of EST or EBS did not influence sensitivity of TB but significantly decreased the incidence of adverse events. To safely and reliably perform TB to diagnose bile duct adenocarcinoma, planning, including for EST and EBS, is necessary.

DOI： 10.1186/s12876-022-02402-x

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Scopus

PubMed

新型コロナウイルス感染拡大が日本の医療・介護・福祉の現場にもたらした初期段階の影響に関する質的研究 査読有り

平野 有希子, 平川 仁尚, 江 啓発, 八谷 寛

東海公衆衛生雑誌   10 巻 ( 1 ) 頁： 85 - 94   2022年7月

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担当区分：最終著者   記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：東海公衆衛生学会  

<p><b>目的</b>　新型コロナウイルス (SARS-COV-2) の感染拡大初期に医療・介護・福祉の現場で起きた課題の構造を整理することは, 今後直面する可能性がある新たな新興感染症への対策策定の第一歩として有用と考えられる。本研究では, 2020年4～5月頃の新型コロナウイルス感染拡大の初期段階における地域の医療・介護・福祉の現場の課題とその構造を実務者の言説の質的分析を通して明らかにすることを目的とした。</p><p><b>方法</b>　医療・介護・福祉従事者27名を対象に2020年4月から5月にオンラインインタビュー調査を実施した。インタビューガイドを用いた半構造化インタビューとし, 自由回答形式で行った。録画したインタビュー内容から逐語録を作成し, テキストデータを質的内容分析により分析した。</p><p><b>結果</b>　質的内容分析の結果, 126種類の意味単位が抽出された。グループ化により, (1) 不足する情報・十分でない情報共有に対する不安や不満, (2) 業務ならびに社会からの差別に対する心身の疲労, (3) 孤独と貧困に対する対応, (4) 感染予防対策における困難さ, の4テーマが抽出された。</p><p><b>結論</b>　本研究の結果から, 新興感染症拡大初期の現場で, 医療資材の不足だけでなく信頼性が高い情報の不足が特に深刻であった。また, 初期に限定した課題ではないが, 医療者の心身の疲労軽減, 孤独や貧困に対する生活支援も重要であった。</p>

DOI： 10.24802/tpha.2022-02

CiNii Research

健診で血圧高値を指摘された高血圧症患者の疾患と治療に対する認識と態度 査読有り

洪 英在, 平川 仁尚, 犬飼 麻里子, 水野 晴子, 江 啓発, 八谷 寛

東海公衆衛生雑誌   10 巻 ( 1 ) 頁： 180 - 186   2022年7月

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担当区分：最終著者   記述言語：日本語   出版者・発行元：東海公衆衛生学会  

<p><b>目的</b>　適切に血圧がコントロールされている人を増やすためには, コントロール不良の高血圧症患者に焦点を当て, その要因を明らかにする必要がある。高血圧症は無症候性であることが多いため, 患者本人の疾患や治療に関する認識への働きかけを行うことが重要であるが, そうした研究は少ない。本研究は, 健診でII度以上の血圧高値を指摘された高血圧患者 (すなわち, 良好なコントロール状態にあるとは判断されない高血圧症患者) の疾患と治療に対する認識や態度を探索することを目的とした。</p><p><b>方法</b>　対象者は, 愛知県岩倉市が2019年度, 2020年度, 2021年度に実施した特定健診受診者の中から, 一度でも収縮期血圧160mmHg以上または拡張期血圧100mmHg以上であった300名に対して研究参加を呼び掛け, 同意が得られた13名とした。データ収集は1回約30分間の1対1の半構造化面接により行われた。データ分析は, 質的内容分析により行われた。</p><p><b>結果</b>　対象者の性別は女性5名, 平均年齢は69.2歳 (60-74歳) であった。2名がBMI 25kg/m²以上の肥満であったがBMI 35kg/m²以上の高度肥満は存在しなかった。13名ともに高血圧症での医療機関通院歴を有し, 8名がかかりつけ医から降圧剤を処方されていた。質的分析の結果, 高血圧に対するイメージ, 治療に関する認識, ピアから受ける影響, 患者からみたかかりつけ医の診療姿勢, 実際に行動変容することの難しさ, の5テーマが抽出された。対象者の中には, 高血圧症に対して重大性を認識していないか, 生活習慣改善に向けて行動を起こすメリットを感じていないようであった。また, 降圧剤について, 必要性を感じず, 副作用を危惧していた。こうした認識は, ピア, つまり同じ疾患を持つ家族・同僚や, かかりつけ医の診療姿勢から影響を受けていた。</p><p><b>結論</b>　コントロールが良好でない可能性がある高血圧症患者の疾患と治療に対する認識と態度として, 行動変容の準備性の低さ, 治療内容に関する否定的な認識, ピアからの影響の大きさ, かかりつけ医の診療姿勢への転嫁的態度が存在する可能性があると考えられた。</p>

DOI： 10.24802/tpha.2022-13

CiNii Research

特定健診およびレセプトデータを用いた愛知県岩倉市における心血管疾患発症リスクおよび人口寄与危険割合に関するコホート研究 査読有り

江 啓発, 藤社 紗梨, 水野 晴子, 平川 仁尚, 八谷 寛

東海公衆衛生雑誌   10 巻 ( 1 ) 頁： 166 - 179   2022年7月

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担当区分：最終著者,　責任著者   記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：東海公衆衛生学会  

<p><b>目的</b>　特定健診とレセプトの分析に基づき保健事業の効果や効率を高めていくこと (データヘルス計画) が保険者には求められているが、課題設定や被保険者への情報提供に資する実態把握には特定健診受診率や有所見者割合、高額医療費者数等の横断的な検討が中心である。そこで本研究は、愛知県岩倉市国民健康保険 (国保) 加入者の特定健診とその後の経年的なレセプト情報を突合したコホート研究データを用い、心血管疾患発症リスクおよび人口寄与危険割合の推定を試みた。</p><p><b>方法</b>　岩倉市国保加入者のうち、2013年から2018年までの5年間に特定健診を1回以上受診した者を対象とし、最初の受診年をベースラインとした。ベースライン以前に心血管疾患の既往歴のある者および問診データに欠損値の多い者を除外した6,496名 (男性2,722名、女性3,774名) を解析対象とした。レセプト情報を用いて追跡期間中の心血管疾患の発症を把握し、特定健診結果から把握した危険因子と全心血管疾患、心筋梗塞、脳卒中の関連を性・年齢および危険因子を相互に調整したCox比例ハザードモデルで検討した。また、多変量調整ハザード比(HR)と発症者における危険因子の割合から人口寄与危険割合を推定した。</p><p><b>結果</b>　解析対象者のベースライン時平均年齢は62.5歳であった。追跡期間中の全心血管疾患、心筋梗塞、脳卒中の発症者数はそれぞれ149名、58名、91名であった。女性に比し男性 (HR : 2.0、95%信頼区間 (CI) : 1.4-2.8)、非現喫煙者に比し現喫煙者 (HR : 1.7、95% CI : 1.1-2.5) は心血管疾患発症リスクが約2倍高かった。非高血圧に比しI度およびII度以上高血圧の心血管疾患発症のハザード比はそれぞれ1.7 (95% CI : 1.1-2.4)、2.3 (95% CI : 1.5-3.5) であった。また、糖尿病 (HR : 2.3、95% CI : 1.4-3.9)、メタボリックシンドローム該当者 (HR : 1.6、95% CI : 1.1-2.3) ともに約2倍の心血管疾患発症リスクと関連した。心血管疾患の人口寄与危険割合は高血圧 (I度以上) で27.2%と最も高く、次いで喫煙11.3% メタボリックシンドローム10.5%、糖尿病10.2%であった。</p><p><b>結論</b>　高血圧、喫煙、糖尿病、メタボリックシンドロームは性、年齢、その他の危険因子に独立して心血管疾患発症リスク上昇と有意に関連した。心血管疾患の人口寄与危険割合は高血圧で最も高かった。</p>

DOI： 10.24802/tpha.2022-12

CiNii Research

Association between C-reactive protein and risk of overall and 18 site-specific cancers in a Japanese case-cohort 査読有り

Suzuki S., Katagiri R., Yamaji T., Sawada N., Imatoh T., Ihira H., Inoue M., Tsugane S., Iwasaki M., Miyamoto Y., Abe S.K., Tanaka S., Moriya T., Minamizono T., Shirai Y., Kuniyoshi H., Yoshimi T., Sonoda H., Tagami T., Ando T., Kimura T., Kokubo Y., Yamagishi K., Mizoue T., Nakamura K., Takachi R., Ishihara J., Iso H., Kitamura T., Saito I., Yasuda N., Mimura M., Sakata K., Noda M., Goto A., Yatsuya H.

British Journal of Cancer   126 巻 ( 10 ) 頁： 1481 - 1489   2022年6月

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記述言語：英語   出版者・発行元：British Journal of Cancer  

Background: Evidence of the association between chronic low-grade inflammation, as reflected by C-reactive protein (CRP) measurements, and cancer risk is equivocal. Specifically, few studies have examined this in uncommon cancers and Asian populations. Methods: We utilised a case-cohort design consisting of multi-types of cancer (N = 3608), and a random subcohort (N = 4432) in a Japanese large population-based study, with a median follow-up time of 15.6 years, and measured baseline plasma CRP using high sensitivity assay. The hazard ratios (HRs) were estimated using weighted Cox proportional hazards methods. Results: The multivariable-adjusted HR (95% confidence interval) for the top quartile of CRP was 1.28 (1.11‒1.48) (Ptrend < 0.001) for overall cancer compared to the bottom quartile of CRP. Among site-specific cancers, higher CRP levels were associated with an increased risk of colorectal, lung, breast, biliary tract, and kidney cancer, and leukaemia. These positive associations remained among participants after >3 years’ follow-up. Furthermore, subgroup analyses for overall cancer robustly showed a positive association with CRP levels, regardless of sex and obesity. Conclusion: Our consistent findings suggested that chronic low-grade inflammation measured by CRP is associated with the risk of cancer.

DOI： 10.1038/s41416-022-01715-8

Scopus

Stoma creation is associated with a low incidence of midline incisional hernia after colorectal surgery: the "fighting over the fascia" theory concerning the incision and stoma hole 査読有り

Ohara, N; Uehara, K; Ogura, A; Sando, M; Aiba, T; Murata, Y; Mizuno, T; Toshio, K; Yokoyama, Y; Ishigaki, S; Li, YY; Yatsuya, H; Ebata, T

SURGERY TODAY   52 巻 ( 6 ) 頁： 953 - 963   2022年6月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Surgery Today  

Purpose: Parastomal hernia (PH) develops more frequently than incisional hernia (IH) after colorectal surgery with stoma. This study evaluated our hypothesis that inward traction of the fascia when closing a midline incision widens the stoma hole and increases the incidence of PH. Methods: A total of 795 patients who underwent colorectal resection between 2006 and 2016 were retrospectively analyzed. The risk classification was constructed from IH risk factors extracted from the non-stoma group. Then, the classification was extrapolated to the stoma group for predicting midline IH and PH. Results: The incidence of IH was 5.3% in the stoma group and 12.5% in the non-stoma group (p = 0.005). PH developed in 19.6% of 97 patients with permanent stoma. The risk classification was able to predict PH without a significant difference but was well balanced in patients with permanent stoma; however, it failed to predict IH in the stoma group. Conclusion: The risk classification constructed from the non-stoma group was useful for predicting not midline IH but PH, suggesting that the stoma site was the most vulnerable for herniation. The “fighting over the fascia” theory between the midline incision and stoma hole may explain the causal relationship between the midline IH and PH.

DOI： 10.1007/s00595-021-02434-y

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Prioritization and sequential exclusion of articles in systematic reviews 査読有り 国際共著 国際誌

Saif-Ur-Rahman, KM; Hasan, M; Hossain, S; Anwar, I; Hirakawa, Y; Yatsuya, H

CAMPBELL SYSTEMATIC REVIEWS   18 巻 ( 2 ) 頁： e1229   2022年6月

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Campbell Systematic Reviews  

It is difficult to match the causes of exclusion among two independent review authors after screening the title and abstract or full texts in systematic reviews. We have proposed the prioritization and sequential exclusion approach to reduce the subjectivity in reporting reasons for exclusion. This approach might reduce the burden of mismatched numbers while describing the cause of exclusion.

DOI： 10.1002/cl2.1229

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PubMed

Implementation strategies for the patient safety reporting system using Consolidated Framework for Implementation Research: a retrospective mixed-method analysis 査読有り

Koike, D; Ito, M; Horiguchi, A; Yatsuya, H; Ota, A

BMC HEALTH SERVICES RESEARCH   22 巻 ( 1 ) 頁： 409   2022年3月

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記述言語：英語   出版者・発行元：BMC Health Services Research  

Background: Healthcare-related adverse events occur because of complex healthcare systems. The patient safety reporting system is a core component of patient safety initiatives in hospitals. However, hospital management often encounters a cultural barrier with its implementation and struggles to overcome the same. Implementation science would be useful for analysing implementation strategies. This study determines the effects of the implemented strategy on an increase in the number of patient safety reports and the determinants of successful implementation, using the implementation framework. Methods: Mixed method analysis was performed in Fujita Health University Hospital (FHUH), a large volume hospital in Japan. We identified strategies to implement the patient safety reporting system by scrutinising internal documents using the Consolidated Framework for Implementation Research (CFIR). The electronic reporting systems developed in 2004 in the FHUH and the number of reports were analysed using the staff data and hospital volumes. Results: Reports (n = 110,058) issued between April 2004 and March 2020 were analysed. The number of reports increased from 2004 to 2008 and from 2013 to 2019, reaching 14,037 reports per year. Between 2009 and 2012, the FHUH experienced a stagnation period where the number of reports were not increasing. From the qualitative materials, we identified 74 strategies which contributed to the implementation of the patient safety reporting system. Among these, the domain of ‘intervention characteristics’ in the CFIR contained 12 strategies, ‘outer settings’ contained 20, ‘inner settings’ contained 21, ‘characteristics of individuals’ contained 8, and ‘process’ contained 13. There were two concentrated periods of the implemented strategies, the number was 17 in 2007 and 10 in 2016. These concentrated periods preceded a remarkable increase in the number of patient safety reports. Conclusions: A safety culture had been fostered in FHUH in the study period. A relationship between number of strategies and development of a reporting culture was observed. The intensity of adequate strategies was needed for implementation of patient safety reporting system. Therefore, the implementation framework is useful for analysing patient safety initiatives for safety culture.

DOI： 10.1186/s12913-022-07822-9

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PubMed

Low Density Lipoprotein Cholesterol Associations With The Risk Of Coronary Heart Disease And Stroke Among Middle-aged Japanese Workers: Analysis Using Inverse Probability Weighting

Al-shoaibi, AA; Li, YY; Chiang, C; Hirakawa, Y; Song, Z; Saif-Ur-Rahman, KM; Masako, S; Masaaki, M; Aoyama, A; Tamakoshi, K; Ota, A; Yatsuya, H

CIRCULATION   145 巻   2022年3月

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（その他学術会議資料等）  

DOI： 10.1161/circ.145.suppl_1.EP32

Web of Science

Smoking cessation, weight gain and risk of cardiovascular disease 査読有り 国際誌

Wang, XW; Dong, JY; Cui, RZ; Muraki, I; Shirai, K; Yamagishi, K; Kokubo, Y; Saito, I; Yatsuya, H; Sawada, N; Iso, H; Tsugane, S

HEART   108 巻 ( 5 ) 頁： 375 - 381   2022年3月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1136/heartjnl-2021-318972

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職業性ストレスと退職後の認知機能低下に関する縦断的研究 愛知職域コホート研究

中島 啓裕, 江 啓発, 平川 仁尚, He Yupeng, 霜田 真子, 玉腰 浩司, 八谷 寛

産業ストレス研究   29 巻 ( 1 ) 頁： 169 - 169   2022年3月

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担当区分：最終著者,　責任著者   記述言語：日本語   掲載種別：研究論文（その他学術会議資料等）   出版者・発行元：日本産業ストレス学会  

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Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019 査読有り 国際共著

Cousin, E; Duncan, BB; Stein, C; Ong, KL; Vos, T; Abbafati, C; Abbasi-Kangevari, M; Abdelmasseh, M; Abdoli, A; Abd-Rabu, R; Abolhassani, H; Abu-Gharbieh, E; Accrombessi, MMK; Adnani, QES; Afzal, MS; Agarwal, G; Agrawaal, KK; Agudelo-Botero, M; Ahinkorah, BO; Ahmad, S; Ahmad, T; Ahmadi, K; Ahmadi, S; Ahmadi, A; Ahmed, A; Salih, YA; Akande-Sholabi, W; Akram, T; Al Hamad, H; Al-Aly, Z; Alcalde-Rabanal, JE; Alipour, V; Aljunid, SM; Al-Raddadi, RM; Alvis-Guzman, N; Amini, S; Ancuceanu, R; Andrei, T; Andrei, CL; Anjana, RM; Ansar, A; Antonazzo, IC; Antony, B; Anyasodor, AE; Arabloo, J; Arizmendi, D; Armocida, B; Artamonov, AA; Arulappan, J; Aryan, Z; Asgari, S; Ashraf, T; Astell-Burt, T; Atorkey, P; Atout, MMW; Ayanore, MA; Badiye, AD; Baig, AA; Bairwa, M; Baker, JL; Baltatu, OC; Banik, PC; Barnett, A; Barone, MTU; Barone-Adesi, F; Barrow, A; Bedi, N; Belete, R; Belgaumi, UI; Bell, AW; Bennett, DA; Bensenor, IM; Beran, D; Bhagavathula, AS; Bhaskar, S; Bhattacharyya, K; Bhojaraja, VS; Bijani, A; Bikbov, B; Birara, S; Bodolica, V; Bonny, A; Brenner, H; Briko, NI; Butt, ZA; dos Santos, FLC; Camera, LA; Campos-Nonato, IR; Cao, Y; Cao, C; Cerin, E; Chakraborty, PA; Chandan, JS; Chattu, VK; Chen, SM; Choi, JYJ; Choudhari, SG; Chowdhury, EK; Chu, DT; Corso, B; Dadras, O; Dai, XC; Damasceno, AAM; Dandona, L; Dandona, R; Dávila-Cervantes, CA; De Neve, JW; Denova-Gutiérrez, E; Dhamnetiya, D; Diaz, D; Ebtehaj, S; Edinur, HA; Eftekharzadeh, S; El Sayed, I; Elgendy, IY; Elhadi, M; Elmonem, MA; Faisaluddin, M; Farooque, U; Feng, XQ; Fernandes, E; Fischer, F; Flood, D; Freitas, M; Gaal, PA; Gad, MM; Gaewkhiew, P; Getacher, L; Ghafourifard, M; Gheshlagh, RG; Ghashghaee, A; Ghith, N; Ghozali, G; Gill, PS; Ginawi, IA; Glushkova, EV; Golechha, M; Gopalani, SV; Guimaraes, RA; Das Gupta, R; Gupta, R; Gupta, VK; Gupta, VB; Gupta, S; Habtewold, TD; Hafezi-Nejad, N; Halwani, R; Hanif, A; Hankey, GJ; Haque, S; Hasaballah, AI; Hasan, SS; Hashi, A; Hassanipour, S; Hay, SI; Hayat, K; Heidari, M; Hossain, MBH; Hossain, S; Hosseini, M; Hoveidamanesh, S; Huang, JJ; Humayun, A; Hussain, R; Hwang, BF; Ibitoye, SE; Ikuta, KS; Inbaraj, LR; Iqbal, U; Islam, MS; Islam, SMS; Islam, RM; Ismail, NE; Isola, G; Itumalla, R; Iwagami, M; Iyamu, IO; Jahani, MA; Jakovljevic, M; Jayawardena, R; Jha, RP; John, O; Jonas, JB; Joo, T; Kabir, A; Kalhor, R; Kamath, A; Kanchan, T; Kandel, H; Kapoor, N; Kayode, GA; Kebede, SA; Keshavarz, P; Keykhaei, M; Khader, YS; Khajuria, H; Khan, MAB; Khan, MN; Khan, M; Khater, AM; Khoja, TAM; Khubchandani, J; Kim, MS; Kim, YJ; Kimokoti, RW; Kisa, S; Kisa, A; Kivimäki, M; Korshunov, VA; Korzh, O; Koyanagi, A; Krishan, K; Defo, BK; Kumar, GA; Kumar, N; Kusuma, D; La Vecchia, C; Lacey, B; Larsson, AO; Lasrado, S; Lee, WC; Lee, CB; Lee, PH; Lee, SWH; Li, MC; Lim, SS; Lim, LL; Lucchetti, G; Majeed, A; Malik, AA; Mansouri, B; Mantovani, LG; Martini, S; Mathur, P; McAlinden, C; Mehedi, N; Mekonnen, T; Menezes, RG; Mersha, AG; Jonasson, JM; Miazgowski, T; Michalek, IM; Mirica, A; Mirrakhimov, EM; Mirza, AZ; Mithra, P; Mohammadian-Hafshejani, A; Mohammadpourhodki, R; Mohammed, A; Mokdad, AH; Molokhia, M; Monasta, L; Moni, MA; Moradpour, F; Moradzadeh, R; Mostafavi, E; Mueller, UO; Murray, CJL; Mustafa, A; Nagel, G; Nangia, V; Naqvi, AA; Nayak, BP; Nazari, J; Ndejjo, R; Negoi, RI; Kandel, N; Nguyen, CT; Nguyen, HLT; Noubiap, JJ; Nowak, C; Oancea, B; Odukoya, OO; Oguntade, AS; Ojo, TT; Olagunju, AT; Onwujekwe, OE; Ortiz, A; Owolabi, MO; Palladino, R; Panda-Jonas, S; Pandi-Perumal, SR; Pardhan, S; Parekh, T; Parvizi, M; Pepito, VCF; Perianayagam, A; Petcu, IR; Pilania, M; Podder, V; Polibin, RV; Postma, MJ; Prashant, A; Rabiee, N; Rabiee, M; Rahimi-Movaghar, V; Rahman, MA; Rahman, MM; Rahman, M; Rahmawaty, S; Rajai, N; Ram, P; Rana, J; Ranabhat, K; Ranasinghe, P; Rao, CR; Rao, S; Rawaf, S; Rawaf, DL; Rawal, L; Renzaho, AMN; Rezaei, N; Rezapour, A; Riahi, SM; Ribeiro, D; Rodriguez, JAB; Roever, L; Rohloff, P; Rwegerera, GM; Ryan, PM; Saber-Ayad, MM; Sabour, S; Saddik, B; Moghaddam, SS; Sahebkar, A; Sahoo, H; Saif-Ur-Rahman, K; Salimzadeh, H; Samaei, M; Sanabria, J; Santric-Milicevic, MM; Sathian, B; Sathish, T; Schlaich, MP; Seidu, AA; Sekerija, M; Kumar, NS; Seylani, A; Shaikh, MA; Shamshad, H; Shawon, MSR; Sheikhbahaei, S; Shetty, JK; Shiri, R; Shivakumar, KM; Shuval, K; Singh, JA; Singh, A; Skryabin, VY; Skryabina, AA; Sofi-Mahmudi, A; Soheili, A; Sun, J; Szerencsés, V; Szócska, M; Tabarés-Seisdedos, R; Tadbiri, H; Tadesse, EG; Tariqujjaman, M; Thankappan, KR; Thapar, R; Thomas, N; Timalsina, B; Tobe-Gai, R; Tonelli, M; Tovani-Palone, MR; Tran, BX; Tripathy, JP; Car, LT; Tusa, BS; Uddin, R; Upadhyay, E; Tahbaz, SV; Valdez, PR; Vasankari, TJ; Verma, M; Villalobos-Daniel, VE; Vladimirov, SK; Vo, B; Vu, GT; Vukovic, R; Waheed, Y; Wamai, RG; Werdecker, A; Wickramasinghe, ND; Winkler, AS; Wubishet, BL; Xu, XY; Xu, SW; Jabbari, SHY; Yatsuya, H; Yaya, S; Yazie, TSY; Yi, SY; Yonemoto, N; Yunusa, I; Zadey, S; Bin Zaman, S; Zamanian, M; Zamora, N; Zastrozhin, MS; Zastrozhina, A; Zhang, ZJ; Zhong, CW; Zmaili, M; Zumla, A; Naghavi, M; Schmidt, MI

LANCET DIABETES & ENDOCRINOLOGY   10 巻 ( 3 ) 頁： 177 - 192   2022年3月

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記述言語：英語   出版者・発行元：The Lancet Diabetes and Endocrinology  

Background: Diabetes, particularly type 1 diabetes, at younger ages can be a largely preventable cause of death with the correct health care and services. We aimed to evaluate diabetes mortality and trends at ages younger than 25 years globally using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods: We used estimates of GBD 2019 to calculate international diabetes mortality at ages younger than 25 years in 1990 and 2019. Data sources for causes of death were obtained from vital registration systems, verbal autopsies, and other surveillance systems for 1990–2019. We estimated death rates for each location using the GBD Cause of Death Ensemble model. We analysed the association of age-standardised death rates per 100 000 population with the Socio-demographic Index (SDI) and a measure of universal health coverage (UHC) and described the variability within SDI quintiles. We present estimates with their 95% uncertainty intervals. Findings: In 2019, 16 300 (95% uncertainty interval 14 200 to 18 900) global deaths due to diabetes (type 1 and 2 combined) occurred in people younger than 25 years and 73·7% (68·3 to 77·4) were classified as due to type 1 diabetes. The age-standardised death rate was 0·50 (0·44 to 0·58) per 100 000 population, and 15 900 (97·5%) of these deaths occurred in low to high-middle SDI countries. The rate was 0·13 (0·12 to 0·14) per 100 000 population in the high SDI quintile, 0·60 (0·51 to 0·70) per 100 000 population in the low-middle SDI quintile, and 0·71 (0·60 to 0·86) per 100 000 population in the low SDI quintile. Within SDI quintiles, we observed large variability in rates across countries, in part explained by the extent of UHC (r2=0·62). From 1990 to 2019, age-standardised death rates decreased globally by 17·0% (−28·4 to −2·9) for all diabetes, and by 21·0% (–33·0 to −5·9) when considering only type 1 diabetes. However, the low SDI quintile had the lowest decline for both all diabetes (−13·6% [–28·4 to 3·4]) and for type 1 diabetes (−13·6% [–29·3 to 8·9]). Interpretation: Decreasing diabetes mortality at ages younger than 25 years remains an important challenge, especially in low and low-middle SDI countries. Inadequate diagnosis and treatment of diabetes is likely to be major contributor to these early deaths, highlighting the urgent need to provide better access to insulin and basic diabetes education and care. This mortality metric, derived from readily available and frequently updated GBD data, can help to monitor preventable diabetes-related deaths over time globally, aligned with the UN's Sustainable Development Targets, and serve as an indicator of the adequacy of basic diabetes care for type 1 and type 2 diabetes across nations. Funding: Bill & Melinda Gates Foundation.

DOI： 10.1016/S2213-8587(21)00349-1

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Everyday wishes of older people living with dementia in care planning: a qualitative study 査読有り

Mamun, MR; Hirakawa, Y; Saif-Ur-Rahman, KM; Sakaguchi, T; Chiang, C; Yatsuya, H

BMC HEALTH SERVICES RESEARCH   22 巻 ( 1 ) 頁： 184   2022年2月

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：BMC Health Services Research  

Background: The dementia care policy in Japan emphasizes the views of people living with dementia in care planning. An exploration of the everyday wishes of older people living with dementia can help clarify their priorities and assist in improving dementia care. This study aimed to explore the everyday wishes of older people living with dementia in Japan. Methods: This qualitative study was conducted in Aichi prefecture in Japan. Older people with mild to moderate dementia were considered for inclusion. Participants were recruited from a dementia outpatient clinic. In-depth interviews were conducted with 36 participants in the same dementia outpatient clinic from January to October 2019. Audio-recorded interviews were transcribed verbatim. Inductive content analysis was carried out to analyze the data. Findings: Participants expressed their everyday wishes within five themes (desire of being connected, freedom to decide, involvement in activities, status quo, and self-reliance). Older people living with dementia loved the connection with their family and wanted to have an enjoyable life by engaging in several activities without others’ interference. They desired to maintain the status quo and not be a burden to others. Conclusions: This study provides evidence on the everyday wishes of people living with dementia. Identified wishes are mostly on emotional aspects of their daily lives. The findings of our study might help provide care for the people living with dementia considering their wishes. Further exploration, including people with severe dementia, is needed.

DOI： 10.1186/s12913-022-07606-1

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その他リンク： https://link.springer.com/article/10.1186/s12913-022-07606-1/fulltext.html

Age and sex differences in factors associated with hypertension among an urban poor population in Bangladesh 査読有り

Al-Shoaibi, AAA; Chiang, CF; Khalequzzaman, M; Choudhury, SR; Hirakawa, Y; Islam, SS; Aoyama, A; Yatsuya, H

NAGOYA JOURNAL OF MEDICAL SCIENCE   84 巻 ( 1 ) 頁： 69 - 79   2022年2月

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担当区分：最終著者   記述言語：英語   出版者・発行元：Nagoya Journal of Medical Science  

This study explores the differences in factors associated with hypertension between younger and older subjects in an urban slum community in Bangladesh. We analyzed the data of 1,008 men and 1,001 women obtained from a cross-sectional survey conducted between October 2015 and April 2016. Multivariable logistic regression models were stratified by age (18 to 44 and 45 to 64 years) in men and women separately. The multivariable model included age (continuous) and the following categorical variables simultaneously: education duration, marital status, tobacco smoking, smokeless tobacco use, total physical activity, body mass index (BMI), waist circumference, and the blood levels of glycated hemoglobin (HbA1c), triglycerides, high and low-density lipoprotein (HDL and LDL) cholesterol. Hypertension was defined as the presence of either blood pressure ≥140/90 mmHg or the use of antihypertensive medication. The prevalence of hypertension was 13.0% (younger men), 14.6% (younger women), 35.6% (older men), and 38.7% (older women). In younger men, higher waist circumference and increased LDL cholesterol levels were significantly associated with hypertension. In older men, physical activity was the only significant factor that was inversely associated with hypertension. In younger women, higher BMI, increased HbA1c, triglycerides, and LDL cholesterol levels were associated with hypertension. In older women, a higher HbA1c was the only factor significantly associated with hypertension. These findings suggest that public health interventions to prevent hypertension may require different approaches according to sex and age groups within the poor urban population in Bangladesh.

DOI： 10.18999/nagjms.84.1.69

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Comparison of laminoplasty and posterior fusion surgery for cervical ossification of posterior longitudinal ligament 査読有り

Nakashima, H; Imagama, S; Yoshii, T; Egawa, S; Sakai, K; Kusano, K; Nakagawa, Y; Hirai, T; Wada, K; Katsumi, K; Fujii, K; Kimura, A; Furuya, T; Kanchiku, T; Nagamoto, Y; Oshima, Y; Nagoshi, N; Ando, K; Takahata, M; Mori, K; Nakajima, H; Murata, K; Matsunaga, S; Kaito, T; Yamada, K; Kobayashi, S; Kato, S; Ohba, T; Inami, S; Fujibayashi, S; Katoh, H; Kanno, H; Li, YY; Yatsuya, H; Koda, M; Kawaguchi, Y; Takeshita, K; Matsumoto, M; Yamazaki, M; Okawa, A

SCIENTIFIC REPORTS   12 巻 ( 1 ) 頁： 748   2022年1月

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記述言語：英語   出版者・発行元：Scientific Reports  

This prospective multicenter study, established by the Japanese Ministry of Health, Labour and Welfare and involving 27 institutions, aimed to compare postoperative outcomes between laminoplasty (LM) and posterior fusion (PF) for cervical ossification of the posterior longitudinal ligament (OPLL), in order to address the controversy surrounding the role of instrumented fusion in cases of posterior surgical decompression for OPLL. 478 patients were considered for participation in the study; from among them, 189 (137 and 52 patients with LM and PF, respectively) were included and evaluated using the Japanese Orthopaedic Association (JOA) scores, the JOA Cervical Myelopathy Evaluation Questionnaire (JOACMEQ), and radiographical measurements. Basic demographic and radiographical data were reviewed, and the propensity to choose a surgical procedure was calculated. Preoperatively, there were no significant differences among the participants in terms of patient backgrounds, radiographical measurements (K-line or cervical alignment on X-ray, OPLL occupation ratio on computed tomography, increased signal intensity change on magnetic resonance imaging), or clinical status (JOA score and JOACMEQ) after adjustments. The overall risk of perioperative complications was found to be lower with LM (odds ratio [OR] 0.40, p = 0.006), and the rate of C5 palsy occurrence was significantly lower with LM (OR 0.11, p = 0.0002) than with PF. The range of motion (20.91° ± 1.05° and 9.38° ± 1.24°, p < 0.0001) in patients who had PF was significantly smaller than in those who had LM. However, multivariable logistic regression analysis showed no significant difference among the participants in JOA score, JOA recovery rate, or JOACMEQ improvement at two years. In contrast, OPLL progression was greater in the LM group than in the PF group (OR 2.73, p = 0.0002). Both LM and PF for cervical myelopathy due to OPLL had resulted in comparable postoperative outcomes at 2 years after surgery.

DOI： 10.1038/s41598-021-04727-1

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Impact of Body Mass Index on Obesity-Related Cancer and Cardiovascular Disease Mortality; The Japan Collaborative Cohort Study 査読有り 国際誌

Matsunaga, M; Yatsuya, H; Iso, H; Li, YY; Yamagishi, K; Tanabe, N; Wada, Y; Ota, A; Tamakoshi, K; Tamakoshi, A

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   29 巻 ( 10 ) 頁： 1547 - 1562   2022年

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担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Journal of Atherosclerosis and Thrombosis  

Aim: We aimed to examine the association of obesity-related cancer and cardiovascular disease (CVD) with body mass index (BMI) and the estimated population attributable fraction in lean Asians. Methods: We studied 102,535 participants aged 40–79 years without histories of cancer or CVD at baseline between 1988 and 2009. The cause-specific hazard ratios (csHRs) of BMI categories (＜18.5, 18.5–20.9, 21.0– 22.9 [reference], 23.0–24.9, 25.0–27.4, and ≥ 27.5 kg/m2) were estimated for each endpoint. The events considered were mortalities from obesity-related cancer (esophageal, colorectal, liver, pancreatic, kidney, female breast, and endometrial cancer) and those from CVD (coronary heart disease and stroke). Population attributable fractions (PAFs) were calculated for these endpoints. Results: During a 19.2-year median follow-up, 2906 died from obesity-related cancer and 4532 died from CVD. The multivariable-adjusted csHRs (95% confidence interval) of higher BMI categories (25–27.4 and ≥ 27.5 kg/m2) for obesity-related cancer mortality were 0.93 (0.78, 1.10) and 1.18 (0.92, 1.50) in men and 1.25 (1.04, 1.50) and 1.48 (1.19, 1.84) in women, respectively. The corresponding csHRs for CVD mortality were 1.27 (1.10, 1.46) and 1.59 (1.30, 1.95) in men and 1.10 (0.95, 1.28) and 1.44 (1.21, 1.72) in women, respectively. The PAF of a BMI ≥ 25 kg/m2 for obesity-related cancer was −0.2% in men and 6.7% in women and that for CVD was 5.0% in men and 4.5% in women. Conclusion: A BMI ≥ 25 kg/m2 is associated with an increased risk of obesity-related cancer in women and CVD in both sexes.

DOI： 10.5551/jat.63143

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Change in the Number of Patient Safety Reports Through a 16-Year Patient Safety Initiative: A Retrospective Study Focusing on the Incident Severity and Type in a Japanese Hospital 査読有り 国際誌

Koike, D; Ito, M; Horiguchi, A; Yatsuya, H; Ota, A

RISK MANAGEMENT AND HEALTHCARE POLICY   15 巻   頁： 2071 - 2081   2022年

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Risk Management and Healthcare Policy  

Purpose: To describe the long-term quantitative change in the number of submissions of patient safety reports after the introduction of a patient safety reporting system, focusing on incident severity and type. Patients and Methods: This study was performed at a tertiary care hospital in Japan. Patient safety reports from 2006 to 2020 were retrospectively reviewed. Incident severity was classified from level 0 (near miss) to level 5 (fatality). The incident types included those related to medication, patient care, drains and catheters, procedures and interventions, examinations, medical devices, and blood transfusions. The study period was divided into 1. 2004–2007; 2. 2008–2014; and 3. 2015–2020 based on the implementation of hospital patient safety strategies. The number of reports per hospital worker was compared among the study periods and the incident levels and types. Results: We analyzed 96,332 reports extracted from the patient safety reporting system of the hospital. The total number of reports per hospital worker has increased over time. The numbers of levels 0 and 1 incidents increased throughout the study period. In addition, levels 3a and 3b incidents increased between periods 2 and 3. All incident types, except for procedure and intervention-related incidents, increased between periods 1 and 2 and between periods 1 and 3. The number of procedure and intervention-related incidents increased between periods 2 and 3, although it did not between periods 1 and 2. Conclusion: We found increases in the number of patient safety reports according to the incident severity and type. This suggests two contextual changes occurring during the cultural maturity process, which reflected the development of organizational patient safety culture in our institution. The first was the establishment of a reporting attitude in the institution. The second was to overcome barriers to patient safety.

DOI： 10.2147/RMHP.S385453

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Prediction of Lifetime Risk of Cardiovascular Disease Deaths Stratified by Sex in the Japanese Population 査読有り 国際誌

Yukiko Imai, Sachiko Mizuno Tanaka, Michihiro Satoh, Takumi Hirata, Yoshitaka Murakami, Katsuyuki Miura, Takashi Waki, Aya Hirata, Toshimi Sairenchi, Fujiko Irie, Mizuki Sata, Toshiharu Ninomiya, Takayoshi Ohkubo, Shizukiyo Ishikawa, Yoshihiro Miyamoto, Hirofumi Ohnishi, Shigeyuki Saitoh, Akiko Tamakoshi, Michiko Yamada, Masahiko Kiyama, Hiroyasu Iso, Kiyomi Sakata, Hideaki Nakagawa, Akira Okayama, Hirotsugu Ueshima, Tomonori Okamura, Yutaka Imai, Akihiko Kitamura, Yutaka Kiyohara, Akiko Harada, Masaru Sakurai, Takeo Nakayama, Ichiro Tsuji, Yoshihiro Kokubo, Hiroshi Yatsuya, Tomonori Okamura

Journal of the American Heart Association   10 巻 ( 23 )   2021年12月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Ovid Technologies (Wolters Kluwer Health)  

<sec xml:lang="en">
<title>Background</title>
<p xml:lang="en">Lifetime risk is an informative estimate for driving lifestyle and behavioral changes especially for young adults. The impact of composite risk factors for cardiovascular disease on lifetime risk stratified by sex has not been investigated in the Japanese population, which has a much lower mortality of coronary heart disease compared with the Western population. We aimed to estimate lifetime risk of death from cardiovascular disease attributable to traditional risk factors.


</sec>
<sec xml:lang="en">
<title>Methods and Results</title>
<p xml:lang="en">We analyzed pooled individual data from the Evidence for Cardiovascular Prevention from Observational Cohorts in a Japanese cohort study. A modified Kaplan–Meier approach was used to estimate the remaining lifetime risk of cardiovascular death. In total, 41 002 Japanese men and women with 537 126 person‐years of follow‐up were included. The lifetime risk at the index‐age of 45 years for those with optimal risk factors (total cholesterol &lt;4.65 mmol/L, systolic blood pressure &lt;120 mm Hg, diastolic blood pressure &lt;80 mm Hg, absence of diabetes, and absence of smoking habit) was lower compared with the highest risk profile of ≥2 risk factors (6.8% [95% CI, 0%–11.9%] versus 19.4% [16.7%–21.4%] for men and 6.9% [1.2%–11.5%] versus 15.4% [12.6%–18.1%] for women).


</sec>
<sec xml:lang="en">
<title>Conclusions</title>
<p xml:lang="en">The magnitude and the number of risk factors were progressively associated with increased lifetime risk even in individuals in early adulthood who tend to have low short‐term risk. The degree of established cardiovascular risk factors can be converted into lifetime risk. Our findings may be useful for risk communication in the early detection of future cardiovascular disease risk.


</sec>

DOI： 10.1161/jaha.121.021753

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Working cancer survivors' physical and mental characteristics compared to cancer-free workers in Japan: a nationwide general population-based study 査読有り 国際誌

Ota, A; Li, YY; Yatsuya, H; Tanno, K; Sakata, K; Yamagishi, K; Iso, H; Yasuda, N; Saito, I; Kato, T; Arima, K; Sou, Y; Shimazu, T; Yamaji, T; Goto, A; Inoue, M; Iwasaki, M; Sawada, N; Tsugane, S

JOURNAL OF CANCER SURVIVORSHIP   15 巻 ( 6 ) 頁： 912 - 921   2021年12月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Journal of Cancer Survivorship  

Purpose: This study compared working cancer survivors’ self-rated health status (SRHS), physical functional capacity, depressive symptoms, and happiness to those of cancer-free workers. Methods: A nationwide general population-based cross-sectional study on a sample of Japanese was conducted. Prevalence of deteriorated SRHS, restricted physical functional capacity, depressive symptoms, and perceived happiness were compared between working cancer survivors and cancer-free workers with multivariable logistic regression analysis adjusted for age and sociodemographic and health-related backgrounds. Results: Of the 28,311 male and 26,068 female workers, 977 (3.5%) and 1267 (4.9%) were cancer survivors, respectively. Working cancer survivors reported deteriorated SRHS more frequently than cancer-free workers: 21.3% vs. 13.8%, multivariable-adjusted odds ratio (95% confidence interval), 1.64 (1.39–1.95) for men, 23.8% vs. 17.5%, 1.34 (1.16–1.54) for women. Restricted physical functional capacity was reported more frequently in working cancer survivors than cancer-free workers: 6.8% vs. 2.6%, 1.76 (1.34–2.32) for men, 4.9% vs. 2.0%, 2.06 (1.56–2.71) for women. No significant difference was found for depressive symptoms: 21.6% vs. 22.9% in men, 30.0% vs. 28.5% in women. Working cancer survivors felt happiness more frequently than cancer-free survivors in men (77.3% vs. 71.7%, 1.21 (1.01–1.45)) but not in women (76.1% vs. 74.9%). Conclusions: Working cancer survivors had worse SRHS and more restricted physical functional capacity than cancer-free workers. In men, working cancer survivors felt happiness more frequently than cancer-free workers. Implications for Cancer Survivors: Continuous support to improve cancer survivors’ SRHS and physical functional capacity would be necessary even while they are working.

DOI： 10.1007/s11764-020-00984-7

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Seasonal variation in submacular hemorrhages in retinal macroaneurysms and its disappearance in age-related macular degeneration 査読有り

Kaneko, H; Takashi, N; Matsunaga, M; Ito, Y; Takeuchi, J; Terasaki, H; Yatsuya, H; Nishiguchi, KM

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY   259 巻 ( 12 ) 頁： 3589 - 3596   2021年12月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Graefe's Archive for Clinical and Experimental Ophthalmology  

Purpose: To investigate whether previously reported seasonal variation and winter-dominant prevalence of acute massive submacular hemorrhages (SMHs) caused by age-related macular degeneration (AMD) disappeared, and those caused by retinal microaneurysms (RMAs) emerged. Method: The medical charts of 95 patients (95 eyes) with SMH caused by AMD and 76 patients (76 eyes) with SMH caused by RMAs in 2012–2019 were retrospectively reviewed. For each subject, the month of onset, the mean ambient temperature of that month were recorded. Results: The monthly numbers of cases of SMHs caused by AMD from January to December were 6, 8, 4, 9, 7, 10, 9, 11, 7, 11, 3, and 10. No significant seasonal variation in the monthly incidence was identified (Roger’s R = 1.89, p = 0.39). The monthly numbers of SMHs caused by RMAs from January to December were 3, 11, 11, 8, 7, 8, 5, 5, 2, 4, 7, and 5. There was significant seasonal variation in the monthly incidence (Roger’s R = 7.67, p = 0.02). There was no significant correlation between the monthly incidence of SMHs caused by RMAs and mean ambient temperature. Conclusion: Our previous study conducted for cases obtained in 1998–2005 showed seasonal cyclic trend in the number of SMHs caused by AMD, with the peak in winter. However, that significant seasonal variation disappeared in 2012–2019 in the present study. Common usage of OCT devices and anti-VEGF drugs might be the reason for the lack of seasonal variation in the cases of SMH caused by AMD. [Figure not available: see fulltext.]

DOI： 10.1007/s00417-021-05280-3

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