研究者詳細 - 八谷　寛

論文 - 八谷　寛

分割表示 338 件中 141 - 160 件目／全件表示 >>

エチオピア北部の公務員における糖尿病および前糖尿病の危険因子(Risk factors of diabetes and prediabetes among public employees in northern Ethiopia) 国際共著

He Yupeng, Chiang Chifa, Gebremariam Lemlem W., Yatsuya Hiroshi, Hirakawa Yoshihisa, Aoyama Atsuko

国際保健医療 34 巻 ( 3 ) 頁： 140 - 141 2019年9月

High-fat and high-cholesterol diet decreases phosphorylated inositol-requiring kinase-1 and inhibits autophagy process in rat liver 査読有り国際誌

Naito, H; Yoshikawa-Bando, Y; Yuan, Y; Hashimoto, S; Kitamori, K; Yatsuya, H; Nakajima, T

SCIENTIFIC REPORTS 9 巻 ( 1 ) 頁： 12514 - 12514 2019年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

Precise molecular pathways involved in the progression of non-alcoholic steatohepatitis (NASH) remain to be elucidated. As Mallory–Denk bodies were occasionally observed in the enlarged hepatocytes in NASH model rat (SHRSP5/Dmcr) fed high-fat and high-cholesterol (HFC) diet, we aimed to clarify the roles of autophagy and endoplasmic reticulum (ER) stress in NASH progression. Male SHRSP5/Dmcr were randomly divided into 4 groups. Two groups were fed a control diet; the other two groups were fed a HFC diet for 2 and 8 weeks, respectively. The HFC diet increased the autophagy-related proteins levels and microtubule-associated protein 1 light chain 3-II/I ratio after 2 and 8 weeks, respectively. However, regarding ER stress-related proteins, the HFC diet decreased the levels of phosphorylated (p-) inositol-requiring kinase-1 (p-IRE-1) and p-protein kinase RNA-like ER kinase after 2 weeks. Additionally, the HFC diet increased anti-ubiquitin-positive cells and the level of the autophagy substrate p62, suggesting that the HFC diet induced dysfunction in ubiquitin-dependent protein degradation pathways. In conclusion, the HFC diet arrested the autophagy process in the liver; this was particularly associated with decreases in p-IRE-1 expression.

DOI： 10.1038/s41598-019-48973-w

Automated Feedback Messages With Shichifukujin Characters Using IoT System-Improved Glycemic Control in People With Diabetes: A Prospective, Multicenter Randomized Controlled Trial. 査読有り国際誌

Kobayashi T, Tsushita K, Nomura E, Muramoto A, Kato A, Eguchi Y, Onoue T, Goto M, Muto S, Yatsuya H, Arima H

Journal of diabetes science and technology 13 巻 ( 4 ) 頁： 796 - 798 2019年7月

Associations of Daily Walking Time With Pneumonia Mortality Among Elderly Individuals With or Without a Medical History of Myocardial Infarction or Stroke: Findings From the Japan Collaborative Cohort Study 査読有り

Ukawa, S; Zhao, WJ; Yatsuya, H; Yamagishi, K; Tanabe, N; Iso, H; Tamakoshi, A; Mori, M; Sakauchi, F; Motohashi, Y; Tsuji, I; Nakamura, Y; Iso, H; Mikami, H; Kurosawa, M; Hoshiyama, Y; Tanabe, N; Tamakoshi, K; Wakai, K; Tokudome, S; Suzuki, K; Hashimoto, S; Kikuchi, S; Wada, Y; Kawamura, T; Watanabe, Y; Ozasa, K; Miki, T; Date, C; Sakata, K; Kurozawa, Y; Yoshimura, T; Fujino, Y; Shibata, A; Okamoto, N; Shio, H

JOURNAL OF EPIDEMIOLOGY 29 巻 ( 6 ) 頁： 233 - 237 2019年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: The association between daily walking and pneumonia mortality, stratified by the presence of disease conditions, such as myocardial infarction (MI) or stroke, was investigated. Methods: The study participants were 22,280 Japanese individuals (9,067 men and 13,213 women) aged 65-79 years. Inverse propensity weighted competing risk model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for pneumonia mortality. Results: After a median of 11.9 years of follow-up, 1,203 participants died of pneumonia. Participants who did not have a history of MI or stroke and who walked for 1 hour=day or more were less likely to die from pneumonia (HR 0.90; 95% CI, 0.82-0.98) than those walked for 0.5 hours=day. A similar inverse association of pneumonia and walking (0.5 hours=day) was observed among participants with a history of MI (HR 0.66; 95% CI, 0.48-0.90). Among the participants with a history of stroke, those who walked for 0.6-0.9 hours=day were less likely to die because of pneumonia (HR 0.65; 95% CI, 0.43-0.98). Conclusions: Regular walking for?1 hour=day may reduce the risk of pneumonia mortality in elderly individuals with or without cardiovascular disease history.

DOI： 10.2188/jea.JE20170341

Socioeconomic and lifestyle factors associated with depressive tendencies in general Japanese men and women: NIPPON DATA2010 査読有り国際誌

Suzuki, H; Kadota, A; Okuda, N; Hayakawa, T; Nishi, N; Nakamura, Y; Arima, H; Miyagawa, N; Satoh, A; Miyamatsu, N; Yanagita, M; Yatsuya, H; Yamagata, Z; Ohkubo, T; Okamura, T; Ueshima, H; Okayama, A; Miura, K

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE 24 巻 ( 1 ) 頁： 37 - 37 2019年5月

Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 査読有り国際共著国際誌

Johnson, CO; Nguyen, M; Roth, GA; Nichols, E; Alam, T; Abate, D; Abd-Allah, F; Abdelalim, A; Abraha, HN; Abu-Rmeileh, NM; Adebayo, OM; Adeoye, AM; Agarwal, G; Agrawal, S; Aichour, AN; Aichour, I; Aichour, MTE; Alahdab, F; Ali, R; Alvis-Guzman, N; Anber, NH; Anjomshoa, M; Arabloo, J; Arauz, A; Ärnlöv, J; Arora, A; Awasthi, A; Banach, M; Barboza, MA; Barker-Collo, SL; Bärnighausen, TW; Basu, S; Belachew, AB; Belayneh, YM; Bennett, DA; Bensenor, IM; Bhattacharyya, K; Biadgo, B; Bijani, A; Bikbov, B; Bin Sayeed, MS; Butt, ZA; Cahuana-Hurtado, L; Carrero, JJ; Carvalho, F; Castañeda-Orjuela, CA; Castro, F; Catalá-López, F; Chaiah, Y; Chiang, PPC; Choi, JYJ; Christensen, H; Chu, DT; Cortinovis, M; Damasceno, AAM; Dandona, L; Dandona, R; Daryani, A; Davletov, K; De Courten, B; De la Cruz-Góngora, V; Degefa, MG; Dharmaratne, SD; Diaz, D; Dubey, M; Duken, EE; Edessa, D; Endres, M; Faraon, EJA; Farzadfar, F; Fernandes, E; Fischer, F; Flor, LS; Ganji, M; Gebre, AK; Gebremichael, TG; Geta, B; Gezae, KE; Gill, PS; Gnedovskaya, EV; Gómez-Dantés, H; Goulart, AC; Grosso, G; Guo, YM; Gupta, R; Haj-Mirzaian, A; Haj-Mirzaian, A; Hamidi, S; Hankey, GJ; Hassen, HY; Hay, SI; Hegazy, MI; Heidari, B; Herial, NA; Hosseini, MA; Hostiuc, S; Irvani, SSN; Islam, SMS; Jahanmehr, N; Javanbakht, M; Jha, RP; Jonas, JB; Józwiak, JJ; Jürisson, M; Kahsay, A; Kalani, R; Kalkonde, Y; Kamil, TA; Kanchan, T; Karch, A; Karimi, N; Karimi-Sari, H; Kasaeian, A; Kassa, TD; Kazemeini, H; Kefale, AT; Khader, YS; Khalil, IA; Khan, EA; Khang, YH; Khubchandani, J; Kim, D; Kim, YJ; Kisa, A; Kivimäki, M; Koyanagi, A; Krishnamurthi, RK; Kumar, GA; Lafranconi, A; Lewington, S; Li, SS; Lo, WD; Lopez, AD; Lorkowski, S; Lotufo, PA; Mackay, MT; Majdan, M; Majdzadeh, R; Majeed, A; Malekzadeh, R; Manafi, N; Mansournia, MA; Mehndiratta, MM; Mehta, V; Mengistu, G; Meretoja, A; Meretoja, TJ; Miazgowski, B; Miazgowski, T; Miller, TR; Mirrakhimov, EM; Mohajer, B; Mohammad, Y; Mohammadoo-Khorasani, M; Mohammed, S; Mohebi, F; Mokdad, AH; Mokhayeri, Y; Moradi, G; Morawska, L; Velásquez, IM; Mousavi, SM; Muhammed, OSS; Muruet, W; Naderi, M; Naghavi, M; Naik, G; Nascimento, BR; Negoi, RI; Nguyen, CT; Nguyen, LH; Nirayo, YL; Norrving, B; Noubiap, JJ; Ofori-Asenso, R; Ogbo, FA; Olagunju, AT; Olagunju, TO; Owolabi, MO; Pandian, JD; Patel, S; Perico, N; Piradov, MA; Polinder, S; Postma, MJ; Poustchi, H; Prakash, V; Qorbani, M; Rafiei, A; Rahim, F; Rahimi, K; Rahimi-Movaghar, V; Rahman, M; Rahman, MA; Reis, C; Remuzzi, G; Renzaho, AMN; Ricci, S; Roberts, NLS; Robinson, SR; Roever, L; Roshandel, G; Sabbagh, P; Safari, H; Safari, S; Safiri, S; Sahebkar, A; Zahabi, SS; Samy, AM; Santalucia, P; Santos, IS; Santos, JV; Milicevic, MMS; Sartorius, B; Sawant, AR; Schutte, AE; Sepanlou, SG; Shafieesabet, A; Shaikh, MA; Shams-Beyranvand, M; Sheikh, A; Sheth, KN; Shibuya, K; Shigematsu, M; Shin, MJ; Shiue, I; Siabani, S; Sobaih, BH; Sposato, LA; Sutradhar, I; Sylaja, PA; Szoeke, CEI; Ao, BJT; Temsah, MH; Temsah, O; Thrift, AG; Tonelli, M; Topor-Madry, R; Tran, BX; Tran, KB; Truelsen, TC; Tsadik, AG; Ullah, I; Uthman, OA; Vaduganathan, M; Valdez, PR; Vasankari, TJ; Vasanthan, R; Venketasubramanian, N; Vosoughi, K; Vu, GT; Waheed, Y; Weiderpass, E; Weldegwergs, KG; Westerman, R; Wolfe, CDA; Wondafrash, DZ; Xu, GL; Yadollahpour, A; Yamada, T; Yatsuya, H; Yimer, EM; Yonemoto, N; Yousefifard, M; Yu, CH; Zaidi, Z; Zamani, M; Zarghi, A; Zhang, YQ; Zodpey, S; Feigin, VL; Vos, T; Murray, CJL

LANCET NEUROLOGY 18 巻 ( 5 ) 頁： 439 - 458 2019年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：The Lancet Neurology

Background: Stroke is a leading cause of mortality and disability worldwide and the economic costs of treatment and post-stroke care are substantial. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic, comparable method of quantifying health loss by disease, age, sex, year, and location to provide information to health systems and policy makers on more than 300 causes of disease and injury, including stroke. The results presented here are the estimates of burden due to overall stroke and ischaemic and haemorrhagic stroke from GBD 2016. Methods: We report estimates and corresponding uncertainty intervals (UIs), from 1990 to 2016, for incidence, prevalence, deaths, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs). DALYs were generated by summing YLLs and YLDs. Cause-specific mortality was estimated using an ensemble modelling process with vital registration and verbal autopsy data as inputs. Non-fatal estimates were generated using Bayesian meta-regression incorporating data from registries, scientific literature, administrative records, and surveys. The Socio-demographic Index (SDI), a summary indicator generated using educational attainment, lagged distributed income, and total fertility rate, was used to group countries into quintiles. Findings: In 2016, there were 5·5 million (95% UI 5·3 to 5·7) deaths and 116·4 million (111·4 to 121·4) DALYs due to stroke. The global age-standardised mortality rate decreased by 36·2% (−39·3 to −33·6) from 1990 to 2016, with decreases in all SDI quintiles. Over the same period, the global age-standardised DALY rate declined by 34·2% (−37·2 to −31·5), also with decreases in all SDI quintiles. There were 13·7 million (12·7 to 14·7) new stroke cases in 2016. Global age-standardised incidence declined by 8·1% (−10·7 to −5·5) from 1990 to 2016 and decreased in all SDI quintiles except the middle SDI group. There were 80·1 million (74·1 to 86·3) prevalent cases of stroke globally in 2016; 41·1 million (38·0 to 44·3) in women and 39·0 million (36·1 to 42·1) in men. Interpretation: Although age-standardised mortality rates have decreased sharply from 1990 to 2016, the decrease in age-standardised incidence has been less steep, indicating that the burden of stroke is likely to remain high. Planned updates to future GBD iterations include generating separate estimates for subarachnoid haemorrhage and intracerebral haemorrhage, generating estimates of transient ischaemic attack, and including atrial fibrillation as a risk factor. Funding: Bill & Melinda Gates Foundation

DOI： 10.1016/S1474-4422(19)30034-1

Association of gamma-glutamyl transferase and alanine aminotransferase with type 2 diabetes mellitus incidence in middle-aged Japanese men: 12-year follow up 査読有り

Kaneko, K; Yatsuya, H; Li, YY; Uemura, M; Chiang, CF; Hirakawa, Y; Ota, A; Tamakoshi, K; Aoyama, A

JOURNAL OF DIABETES INVESTIGATION 10 巻 ( 3 ) 頁： 837 - 845 2019年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Diabetes Investigation

Aims/Introduction: To prospectively investigate whether simultaneous elevation of gamma-glutamyl transferase (GGT) and alanine aminotransferase (ALT) is associated with the increase of type 2 diabetes mellitus incidence independent of alcohol drinking, body mass index and triglycerides. Methods: A total of 2,775 Japanese male workers who had no history of type 2 diabetes mellitus were followed. High GGT and ALT were defined as the top tertiles (GGT cutpoint: 49 IU/L, ALT cutpoint: 28 IU/L). Three groups were created using these dichotomized GGT and ALT cutpoints: both low, either high or both high. Multivariable Cox proportional hazards models were carried out adjusted for potential confounding factors. Results: A total of 276 type 2 diabetes mellitus cases were identified during 12 years (27,040 person-years) of follow up. Participants with simultaneously elevated GGT and ALT had a significantly higher incidence of type 2 diabetes mellitus, even after adjustment for fasting insulin and fasting blood glucose compared with the group without GGT or ALT elevation. Similar associations were observed in non- or light-to-moderate alcohol drinkers, as well as in participants with normal weight. However, the association was weaker in participants with triglycerides <150 mg/dL. We then evaluated whether the addition of GGT and ALT would improve the prediction of type 2 diabetes mellitus incidence, and found that their inclusion significantly increased the C-statistic, net reclassification improvement and integrated discrimination improvement. Conclusions: Simultaneous elevation of GGT and ALT was significantly associated with type 2 diabetes mellitus incidence, independent of potential confounding factors, including alcohol drinking and obesity, although the association might require concomitant elevation of triglycerides. Inclusion of GGT and ALT improved type 2 diabetes mellitus risk prediction.

DOI： 10.1111/jdi.12930

Working Hours and Risk of Acute Myocardial Infarction and Stroke Among Middle-Aged Japanese Men - The Japan Public Health Center-Based Prospective Study Cohort II 査読有り

Hayashi, R; Iso, H; Yamagishi, K; Yatsuya, H; Saito, I; Kokubo, Y; Eshak, ES; Sawada, N; Tsugane, S

CIRCULATION JOURNAL 83 巻 ( 5 ) 頁： 1072 - 1079 2019年5月

特定保健指導レベルと2型糖尿病発症の関連・その臨床疫学的指標愛知職域コホート

金子佳世, 八谷寛, 李媛英, 上村真由, 江啓発, 平川仁尚, 内藤久雄, 太田充彦, 玉腰浩司, 青山温子

産業衛生学雑誌 61 巻 ( 臨増 ) 頁： 321 - 321 2019年5月

トリクロロエチレンによるCYP2E1抗体上昇とhypersensitivity syndromeとの関係

那須民江, 王海蘭, 袁媛, 内藤久雄, 伊藤由起, 八谷寛, 上島通浩

産業衛生学雑誌 61 巻 ( 臨増 ) 頁： 332 - 332 2019年5月

Recent Status and Methodological Quality of Return-to-Work Rates of Cancer Patients Reported in Japan: A Systematic Review 査読有り国際誌

Ota, A; Fujisawa, A; Kawada, K; Yatsuya, H

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 16 巻 ( 8 ) 2019年4月

Validation of the Japanese Version of the Yale Food Addiction Scale 2.0 (J-YFAS 2.0) 査読有り国際共著

Khine, MT; Ota, A; Gearhardt, AN; Fujisawa, A; Morita, M; Minagawa, A; Li, YY; Naito, H; Yatsuya, H

NUTRIENTS 11 巻 ( 3 ) 頁： 687 - 687 2019年3月

Prevalence and Correlates of Dyslipidemia Among Men and Women in Palau: Findings of the Palau STEPS Survey 2011-2013 査読有り国際共著

Cui, MS; Chiang, CF; Cui, RZ; Honjo, K; Yatsuya, H; Watson, BM; Ikerdeu, E; Mita, T; Madraisau, S; Aoyama, A; Iso, H

JOURNAL OF EPIDEMIOLOGY 29 巻 ( 3 ) 頁： 97 - 103 2019年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: Epidemiological evidence of dyslipidemia in Pacific Island countries is limited despite the knowledge that non-communicable diseases have a high burden in the region. We aimed to examine the prevalence and correlates of dyslipidemia among residents of Palau. Methods: The Palau STEPwise approach to Surveillance (STEPS), which was conducted from 2011 through 2013, comprised three parts: behavioral risk factors; physical measurements; and biochemical tests, covering areas such as blood lipids. We used STEPS-generated data to perform a cross-sectional study of 2,184 randomly selected Palau residents, comprising Palauans and non-Palauans aged 25–64 years. Results: The age-adjusted mean BMI was 29.3 kg/m 2 in men and 29.9 kg/m 2 in women; age-adjusted mean triglycerides value was 182 mg/dL in men and 166 mg/dL in women; and age-adjusted mean cholesterol was 178 mg/dL in men and 183 mg/dL in women. The prevalence of overweight/obesity (BMI ≥25 kg/m 2 ) was 75% in men and 76% in women, and those of hypertriglyceridemia (triglycerides ≥150 mg/dL) and hypercholesterolemia (total cholesterol ≥200 mg/dL) were 48% in men and 41% in women and 18% in men and 23% in women, respectively. Mean values of total cholesterol were 177 mg/dL in Palauan men and 182 mg/dL in non-Palauan men. Mean values of triglycerides were 171 mg/dL in Palauan women and 150 mg/dL in non-Palauan women. Women living in rural areas showed a higher mean value of total cholesterol than those in urban areas. Conclusion: We found a high mean BMI and high prevalence of overweight/obesity and hypertriglyceridemia, but low mean total cholesterol and a low prevalence of hypercholesterolemia in Palau. Lipid profiles varied by age, ethnicity, and living area.

DOI： 10.2188/jea.JE20170127

Multicenter feasibility study of bowel preparation with castor oil for colon capsule endoscopy 査読有り国際誌

Ohmiya, N; Hotta, N; Mitsufuji, S; Nakamura, M; Omori, T; Maeda, K; Okuda, K; Yatsuya, H; Tajiri, H

DIGESTIVE ENDOSCOPY 31 巻 ( 2 ) 頁： 164 - 172 2019年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Digestive Endoscopy

Background and Aim: Extensive use of laxatives and incomplete excretion rates are problematic for colon capsule endoscopy (CCE). The aim of the present study was to determine the effectiveness of castor oil as a booster. Methods: At four Japanese hospitals, 319 examinees undergoing CCE were enrolled retrospectively. Before and after the introduction of castor oil, other preparation reagents were unchanged. Results: Of 319 examinees who underwent CCE, 152 and 167 examinees took regimens with castor oil (between November 2013 and June 2016) and without castor oil (between October 2015 and September 2017), respectively. Capsule excretion rates within its battery life in the groups with and without castor oil were 97% and 81%, respectively (P < 0.0001). Multivariate analysis showed that ages younger than 65 years (adjusted odds ratio [OR], 3.00; P = 0.0048), male gender (adjusted OR, 3.20; P = 0.0051), and use of castor oil (adjusted OR, 6.29; P = 0.0003) were predictors of capsule excretion within its battery life. Small bowel transit time was shorter and total volume of lavage and fluid intake was lower with castor oil than without (P = 0.0154 and 0.0013, respectively). Overall adequate cleansing level ratios with and without castor oil were 74% and 83%, respectively (P = 0.0713). Per-examinee sensitivity for polyps ≥6 mm with and without castor oil was 83% and 85%, respectively, with specificities of 80% and 78%, respectively. Conclusion: Bowel preparation with castor oil was effective for improving capsule excretion rate and reducing liquid loading.

DOI： 10.1111/den.13259

Sleep duration and risk of breast cancer: The JACC Study 査読有り

Cao, JH; Eshak, ES; Liu, KY; Muraki, I; Cui, RZ; Iso, H; Tamakoshi, A; Tamakoshi, A; Mori, M; Kaneko, Y; Tsuji, I; Nakamura, Y; Yamagishi, K; Mikami, H; Kurosawa, M; Hoshiyama, Y; Tanabe, N; Tamakoshi, K; Wakai, K; Tokudome, S; Suzuki, K; Hashimoto, S; Yatsuya, H; Kikuchi, S; Wada, Y; Kawamura, T; Watanabe, Y; Ozasa, K; Mikami, K; Date, C; Sakata, K; Kurozawa, Y; Yoshimura, T; Fujino, Y; Shibata, A; Okamoto, N; Shio, H

BREAST CANCER RESEARCH AND TREATMENT 174 巻 ( 1 ) 頁： 219 - 225 2019年2月

Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium 査読有り国際共著国際誌

Inker, LA; Grams, ME; Levey, AS; Coresh, J; Cirillo, M; Collins, JF; Gansevoort, RT; Gutierrez, OM; Hamano, T; Heine, GH; Ishikawa, S; Jee, SH; Kronenberg, F; Landray, MJ; Miura, K; Nadkarni, GN; Peralta, CA; Rothenbacher, D; Schaeffner, E; Sedaghat, S; Shlipak, MG; Zhang, LX; van Zuilen, AD; Hallan, S; Kovesdy, CP; Woodward, M; Levin, A; Astor, B; Appel, LJ; Greene, T; Chen, TK; Chalmers, J; Arima, H; Perkovic, V; Yatsuya, H; Tamakoshi, K; Li, YY; Hirakawa, Y; Matsushita, K; Grams, M; Sang, YY; Polldnghorne, K; Chadban, S; Atkins, R; Djurdjev, O; Liu, LS; Zhao, MH; Wang, F; Wang, JW; Ebert, N; Martus, P; Tang, ML; Heine, G; Emrich, I; Seiler, S; Zawada, A; Nally, J; Navaneethan, SD; Schold, JD; Zhao, MH; Sarnak, MJ; Katz, R; Hiramoto, J; Iso, H; Yamagishi, K; Umesawa, M; Murald, I; Fukagawa, M; Maruyama, S; Hasegawa, T; Fujii, N; Wheeler, DC; Emberson, J; Townend, J; Landray, M; Brenner, H; Schöttker, B; Saum, KU; Fox, C; Hwang, SJ; Köttgen, A; Schneider, MP; Eckardt, KU; Green, JA; Kirchner, HL; Chang, AR; Ho, K; Ito, S; Miyazaki, M; Nakayama, M; Yamada, G; Irie, F; Sairenchi, T; Yano, Y; Kotani, K; Nakamura, T; Kimm, H; Mok, Y; Chodick, G; Shalev, V; Wetzels, JFM; Blankestijn, PJ; van den Brand, JA; Sarnak, M; Peralta, C; Kollerits, B; Ritz, E; Nitsch, D; Roderick, P; Fletcher, A; Bottinger, E; Ellis, SB; Nadukuru, R; Ueshima, H; Okayama, A; Miura, K; Tanaka, S; Okamura, T; Kadota, A; Kenealy, T; Elley, CR; Drury, PL; Ohkubo, T; Asayama, K; Metold, H; Kikuya, M; Nelson, RG; Knowler, WC; Bakker, SJL; Hak, E; Heerspink, HJL; Brunskill, NJ; Major, RW; Shepherd, D; Medcalf, JF; Bernardo, R; Jassal, SK; Bergstrom, J; Ix, JH; Barrett-Connor, E; Kalantar-Zadeh, K; Sumida, K; Muntner, P; Warnock, D; McClellan, W; de Zeeuw, D; Brenner, B; Ikram, MA; Hoorn, EJ; Dehghan, A; Carrero, JJ; Gasparini, A; Wettermark, B; Elinder, CG; Wong, TY; Sabanayagam, C; Cheng, CY; Sokor, RBBMA; Visseren, FLJ; Evans, M; Segelmark, M; Stendahl, M; Schön, S; Tangri, N; Sud, M; Naimark, DM; Wen, CP; Tsao, CK; Tsai, MK; Chen, CH; Konta, T; Hirayama, A; Ichikawa, K; Lannfelt, L; Larsson, A; Ärnlöv, J; Bilo, HJG; Landman, GWD; van Hateren, KJJ; Kleefstra, N; Hallan, S; Ballew, SH; Chen, JS; Kwak, L; Surapaneni, A

AMERICAN JOURNAL OF KIDNEY DISEASES 73 巻 ( 2 ) 頁： 206 - 217 2019年2月

Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium 査読有り国際共著

Chang, AR; Grams, ME; Ballew, SH; Bilo, H; Correa, A; Evans, M; Gutierrez, OM; Hosseinpanah, F; Iseki, K; Kenealy, T; Klein, B; Kronenberg, F; Lee, BJ; Li, YY; Miura, K; Navaneethan, SD; Roderick, PJ; Valdivielso, JM; Visseren, FLJ; Zhang, LX; Gansevoort, RT; Hallan, SI; Levey, AS; Matsushita, K; Shalev, V; Woodward, M; Astor, B; Appel, L; Greene; Chen, T; Chalmers, J; Woodward, M; Arima, H; Perkovic, V; Yatsuya, H; Tamakoshi, K; Li, Y; Hirakawa, Y; Coresh, J; Matsushita, K; Grams, M; Sang, Y; Polkinghorne, K; Chadban, S; Atkins, R; Levin, A; Djurdjev, O; Dam, B; Klein, R; Klein, B; Lee, K; Zhang, LX; Liu, LS; Zhao, MH; Wang, F; Wang, JW; Levin, A; Djurdjev, O; Tang, M; Heine, G; Emrich, I; Zawada, A; Bauer, L; Nally, J; Navaneethan, S; Schold, J; Zhang, LX; Zhao, MH; Wang, F; Wang, JW; Shlipak, M; Sarnak, M; Katz, R; Hiramoto, J; Iso, H; Yamagishi, K; Umesawa, M; Muraki, I; Fukagawa, M; Maruyama, S; Hamano, T; Hasegawa, T; Fujii, N; Jafar, T; Hatcher, J; Poulter, N; Chaturvedi, N; Wheeler, D; Emberson, J; Townend, J; Landray, M; Hermann; Brenner; Schöttker, B; Saum, KU; Rothenbacher, D; Fox, C; Hwang, SJ; Köttgen, A; Kronenberg, F; Schneider, MP; Eckardt, KU; Green, J; Kirchner, HL; Chang, AR; Ito, S; Miyazaki, M; Nakayama, M; Yamada, G; Cirillo, M; Hallan, S; Romundstad, S; Ovrehus, M; Langlo, KA; Irie, F; Sairenchi, T; Correa, A; Rebholz, CM; Young, B; Boulware, LE; Ishikawa, S; Yano, Y; Kotani, K; Nakamura, T; Jee, SH; Kimm, H; Mok, Y; Lee, BJ; Chodick, G; Shalev, V; Wetzels, JFM; Blankestijn, PJ; van Zuilen, AD; Bots, M; Sarnak, M; Inker, L; Shlipak, M; Sarnak, M; Katz, R; Peralta, C; Kronenberg, F; Kollerits, B; Ritz, E; Nitsch, D; Roderick, P; Fletcher, A; Bottinger, E; Nadkarni, GN; Ellis, SB; Nadukuru, R; Valdivielso, JM; Fernandez, E; Betriu, A; Bermudez-Lopez, M; Stengel, B; Metzger, M; Flamant, M; Houillier, P; Haymann, JP; Froissart, M; Sang, YY; Ueshima, H; Okayama, A; Miura, K; Tanaka, S; Ueshima, H; Okamura, T; Miura, K; Tanaka, S; Kenealy, T; Elley, CR; Collins, JF; Drury, PL; Ohkubo, T; Asayama, K; Metoki, H; Kikuya, M; Nakayama, M; Iseki, K; Iseki, C; Nelson, RG; Knowler, WC; Gansevoort, RT; Bakker, SJL; Heerspink, HJL; Brunskill, N; Major, R; Shepherd, D; Medcalf, J; Bernardo, R; Jassal, SK; Bergstrom, J; Joachim, H; Barrett-Connor, E; Kovesdy, C; Kalantar-Zadeh, K; Sumida, K; Muntner, P; Warnock, D; Judd, S; Panwar, B; Heerspink, HJL; de Zeeuw, D; Brenner, B; Sedaghat, S; Ikram, MA; Hoorn, EJ; Dehghan, A; Wong, TY; Sabanayagam, C; Cheng, CY; Binte, RB; Sokor, MA; Visseren, FLJ; Evans, M; Segelmark, M; Stendahl, M; Schön, S; Tangri, N; Sud, M; Naimark, D; Wen, CP; Tsao, K; Tsai, MK; Chen, CH; Konta, T; Hirayama, A; Ichikawa, K; Hosseinpanah, F; Hadaegh, F; Mirbolouk, M; Azizi, F; Solbu, MD; Jenssen, TG; Eriksen, BO; Eggen, AE; Lannfelt, L; Larsson, A; Ärnlöv, J; Bilo, HJG; Landman, GWD; Van Hateren, KJJ; Kleefstra, N; Coresh, J; Gansevoort, RT; Grams, ME; Hallan, S; Kovesdy, CP; Levey, AS; Matsushita, K; Shalev, V; Woodward, M; Ballew, SH; Chen, JS; Coresh, J; Grams, ME; Kwak, L; Matsushita, K; Sang, YY; Surapaneni, A; Woodward, M

BMJ-BRITISH MEDICAL JOURNAL 364 巻 2019年1月

Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 査読有り国際共著国際誌

James, SL; Theadom, A; Ellenbogen, RG; Bannick, MS; Mountjoy-Venning, WC; Lucchesi, LR; Abbasi, N; Abdulkader, R; Abraha, HN; Adsuar, JC; Afarideh, M; Agrawal, S; Ahmadi, A; Ahmed, MB; Aichour, AN; Aichour, I; Aichour, MTE; Akinyemi, RO; Akseer, N; Alahdab, F; Alebel, A; Alghnam, SA; Ali, BA; Alsharif, U; Altirkawi, K; Andrei, CL; Anjomshoa, M; Ansari, H; Ansha, MG; Antonio, CAT; Appiah, SCY; Ariani, F; Asefa, NG; Asgedom, SW; Atique, S; Awasthi, A; Quintanilla, BPA; Ayuk, TB; Azzopardi, PS; Badali, H; Badawi, A; Balalla, S; Banstola, A; Barker-Collo, SL; Bärnighausen, TW; Bedi, N; Behzadifar, M; Behzadifar, M; Bekele, BB; Belachew, AB; Belay, YA; Bennett, DA; Bensenor, IM; Berhane, A; Beuran, M; Bhalla, A; Bhaumik, S; Bhutta, ZA; Biadgo, B; Biffino, M; Bijani, A; Bililign, N; Birungi, C; Boufous, S; Brazinova, A; Brown, AW; Car, M; Cárdenas, R; Carrero, JJ; Carvalho, F; Castañeda-Orjuela, CA; Catalá-López, F; Chaiah, Y; Champs, AP; Chang, JC; Choi, JYJ; Christopher, DJ; Cooper, C; Crowe, CS; Dandona, L; Dandona, R; Daryani, A; Davitoiu, DV; Degefa, MG; Demoz, GT; Deribe, K; Djalalinia, S; Do, HP; Doku, DT; Drake, TM; Dubey, M; Dubljanin, E; El-Khatib, Z; Eskandarieh, S; Esteghamati, A; Esteghamati, S; Faro, A; Farzadfar, F; Farzaei, MH; Fereshtehnejad, SM; Fernandes, E; Feyissa, GT; Filip, I; Fischer, F; Fukumoto, T; Ganji, M; Gankpe, FG; Gebre, AK; Gebrehiwot, TT; Gezae, KE; Gopalkrishna, G; Goulart, AC; Haagsma, JA; Haj-Mirzaian, A; Haj-Mirzaian, A; Hamadeh, RR; Hamidi, S; Haro, JM; Hassankhani, H; Hassen, HY; Havmoeller, R; Hawley, C; Hay, SI; Hegazy, MI; Hendrie, D; Henok, A; Hibstu, DT; Hoffman, HJ; Hole, MK; Rad, EH; Hosseini, SM; Hostiuc, S; Hu, G; Hussen, MA; Ilesanmi, OS; Irvani, SN; Jakovljevic, M; Jayaraman, S; Jha, RP; Jonas, JB; Jones, KM; Shushtari, ZJ; Jozwiak, JJ; Jürisson, M; Kabir, A; Kahsay, A; Kahssay, M; Kalani, R; Karch, A; Kasaeian, A; Kassa, GM; Kassa, TD; Kassa, ZY; Kengne, AP; Khader, YS; Khafaie, MA; Khalid, N; Khalil, I; Khan, EA; Khan, MS; Khang, YH; Khazaie, H; Khoja, AT; Khubchandani, J; Kiadaliri, AA; Kim, D; Kim, YE; Kisa, A; Koyanagi, A; Krohn, KJ; Defo, BK; Bicer, BK; Kumar, GA; Kumar, M; Lalloo, R; Lami, FH; Lansingh, VC; Laryea, DO; Latifi, A; Leshargie, CT; Levi, M; Li, SS; Liben, ML; Lotufo, PA; Lunevicius, R; Mahotra, NB; Majdan, M; Majeed, A; Malekzadeh, R; Manda, AL; Mansournia, MA; Massenburg, BB; Mate, KKV; Mehndiratta, MM; Mehta, V; Meles, H; Melese, A; Memiah, PTN; Mendoza, W; Mengistu, G; Meretoja, A; Meretoja, TJ; Mestrovic, T; Miazgowski, T; Miller, TR; Mini, GK; Mirica, A; Mirrakhimov, EM; Moazen, B; Mohammadi, M; Mokdad, AH; Molokhia, M; Monasta, L; Mondello, S; Moosazadeh, M; Moradi, G; Moradi, M; Moradi-Lakeh, M; Moradinazar, M; Morrison, SD; Moschos, MM; Mousavi, SM; Murthy, S; Musa, KI; Mustafa, G; Naghavi, M; Naik, G; Najafi, F; Nangia, V; Nascimento, BR; Negoi, I; Nguyen, TH; Nichols, E; Ningrum, DNA; Nirayo, YL; Nyasulu, PS; Ofori-Asenso, R; Ogbo, FA; Oh, IH; Okoro, A; Olagunju, AT; Olagunju, TO; Olivares, PR; Otstavnov, SS; Owolabi, MO; Mahesh, PA; Pakhale, S; Pandey, AR; Pesudovs, K; Pinilla-Monsalve, GD; Polinder, S; Poustchi, H; Prakash, S; Qorbani, M; Radfar, A; Rafay, A; Rafiei, A; Rahimi-Movaghar, A; Rahimi-Movaghar, V; Rahman, M; Rahman, MA; Rai, RK; Rajati, F; Ram, U; Rawaf, DL; Rawaf, S; Reiner, RC; Reis, C; Renzaho, AMN; Resnikoff, S; Rezaei, S; Rezaeian, S; Roever, L; Ronfani, L; Roshandel, G; Roy, N; Ruhago, GM; Saddik, B; Safari, H; Safiri, S; Sahraian, MA; Salamati, P; Saldanha, RD; Samy, AM; Sanabria, J; Santos, JV; Milicevic, MMMS; Sartorius, B; Satpathy, M; Schneider, IJC; Schwebel, DC; Sepanlou, SG; Shabaninejad, H; Shaikh, MAA; Shams-Beyranvand, M; Sharif, M; Sharif-Alhoseini, M; Islam, SMS; She, J; Sheikh, A; Shen, JB; Sheth, KN; Shibuya, K; Shiferaw, MS; Shigematsu, M; Shiri, R; Shiue, I; Shoman, H; Siabani, S; Siddiqi, TJ; Silva, JP; Silveira, DGA; Sinha, DN; Smith, M; Soares, AM; Sobhani, S; Soofi, M; Soriano, JB; Soyiri, IN; Stein, DJ; Stokes, MA; Sufiyan, MB; Sunguya, BF; Sunshine, JE; Sykes, BL; Szoeke, CEI; Tabares-Seisdedos, R; Ao, BJT; Tehrani-Banihashemi, A; Tekle, MG; Temsah, MH; Temsah, O; Topor-Madry, R; Tortajada-Girbés, M; Tran, BX; Tran, KB; Car, LT; Ukwaja, KN; Ullah, I; Usman, MS; Uthman, OA; Valdez, PR; Vasankari, TJ; Venketasubramanian, N; Violante, FS; Wagnew, FS; Waheed, Y; Wang, YP; Weldegwergs, KG; Werdecker, A; Wijeratne, T; Winkler, AS; Wyper, GMA; Yano, Y; Yaseri, M; Yasin, YJ; Ye, PP; Yimer, EM; Yip, P; Yisma, E; Yonemoto, N; Yoon, SJ; Yost, MG; Younis, MZ; Yousefifard, M; Yu, CH; Zaidi, Z; Bin Zaman, S; Zamani, M; Zenebe, ZM; Zodpey, S; Feigin, VL; Vos, T; Murray, CJL

LANCET NEUROLOGY 18 巻 ( 1 ) 頁： 56 - 87 2019年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：The Lancet Neurology

Background: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders. Methods: We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach. Findings: Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247–308]) and second leading cause of deaths (9·0 million [8·8–9·4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34–44] and DALYs by 15% [9–21]) whereas their age-standardised rates decreased (deaths by 28% [26–30] and DALYs by 27% [24–31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42·2% [38·6–46·1]), migraine (16·3% [11·7–20·8]), Alzheimer's and other dementias (10·4% [9·0–12·1]), and meningitis (7·9% [6·6–10·4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1·12 [1·05–1·20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0·7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88·8% (86·5–90·9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer's disease and other dementias (22·3% [11·8–35·1] of DALYs are risk attributable) and idiopathic epilepsy (14·1% [10·8–17·5] of DALYs are risk attributable). Interpretation: Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies. Funding: Bill & Melinda Gates Foundation.

DOI： 10.1016/S1474-4422(18)30415-0

Lifetime Risk of Stroke and Coronary Heart Disease Deaths According to Blood Pressure Level: EPOCH-JAPAN (Evidence for Cardiovascular Prevention From Observational Cohorts in Japan) 査読有り国際誌

Satoh, M; Ohkubo, T; Asayama, K; Murakami, Y; Sugiyama, D; Yamada, M; Saitoh, S; Sakata, K; Irie, F; Sairenchi, T; Ishikawa, S; Kiyama, M; Ohnishi, H; Miura, K; Imai, Y; Ueshima, H; Okamura, T; Iso, H; Kitamura, A; Ninomiya, T; Kiyohara, Y; Nakagawa, H; Nakayama, T; Okayama, A; Sairenchi, T; Tamakoshi, A; Tsuji, I; Miyamoto, Y; Ishikawa, S; Yatsuya, H; Okamura, T

HYPERTENSION 73 巻 ( 1 ) 頁： 52 - 59 2019年1月

Smoking results in accumulation of ectopic fat in the liver 査読有り国際誌

Kato, A; Li, YY; Ota, A; Naito, H; Yamada, H; Nihashi, T; Hotta, Y; Chiang, C; Hirakawa, Y; Aoyama, A; Tamakoshi, K; Yatsuya, H

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY 12 巻頁： 1075 - 1079 2019年

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Diabetes, Metabolic Syndrome and Obesity

Objective: An association between smoking and nonalcoholic fatty liver disease has been reported. However, objective quantification of intrahepatic fat via magnetic resonance spectroscopy (MRS) in relation to smoking has rarely been performed in previous studies. Moreover, the possible pathways via which smoking could induce ectopic fat accumulation have not yet been addressed. The current study aimed to examine the association between smoking status and intrahepatic fat quantity and explore the possible mediating effects of triglycerides (TG) and adiponectin. Subjects and methods: Magnetic resonance imager (MRI) spectra were analyzed to quantify intrahepatic fat in 45 men who were on average 62.3 years of age. Smoking status and alcohol intake were self-reported. Accelerometers were used to record daily total physical activity. Fasting blood TG and adiponectin levels were measured enzymatically. Differences in mean intrahepatic fat values according to smoking status were assessed using analysis of covariance. Results: A stepwise increase in mean intrahepatic fat was observed between never, former, and current smokers, respectively, independent of age, physical activity, alcohol intake, and body mass index (BMI) (P=0.005). Adjustment for TG and adiponectin significantly attenuated this association (P=0.074). Conclusion: Current smoking was significantly associated with increased intrahepatic fat, which may be a result of adipocyte dysfunction, manifested as high circulating TG concentrations and low adiponectin levels.

DOI： 10.2147/DMSO.S212495

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