研究者詳細 - 八谷　寛

論文 - 八谷　寛

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Renal Dysfunction after Rectal Cancer Surgery: A Long-term Observational Study 査読有り

Sando, M; Uehara, K; Li, YY; Ogura, A; Murata, Y; Mizuno, T; Yatsuya, H; Ebata, T

JOURNAL OF THE ANUS RECTUM AND COLON 7 巻 ( 3 ) 頁： 176 - 185 2023年

Increasing Role of Overweight/Obesity as the Determinant of Hypertension and the Consequent Cardiovascular Diseases in Japan

Yatsuya, H

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 30 巻 ( 4 ) 頁： 323 - 325 2023年

Psychological Distress During the Coronavirus Disease 2019 Pandemic and Associated Factors Among Undergraduate Students in Japan 査読有り

Sato, Y; Yatsuya, H; Saijo, Y; Yoshioka, E; Tabuchi, T

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS 17 巻 ( 12 ) 頁： e294 2022年12月

記述言語：英語出版者・発行元：Disaster Medicine and Public Health Preparedness

Objective: This cross-sectional study aimed to examine factors potentially associated with psychological distress among undergraduate students during the coronavirus disease 2019 pandemic in Japan. Methods: We analyzed data of 958 undergraduates (median age 20 y; 56.8% women) from a Web-based, self-administered questionnaire survey conducted from August to September 2020. Prevalence ratios (PRs) for psychological distress defined as 5 points or over of the Kessler Psychological Distress Scale (K6) were calculated by Poisson regression models. Results: The proportion of psychological distress was 40.0%. In the mutually-adjusted model, the following were significantly associated with psychological distress: decreases in household income to 50-99% of the prepandemic amount compared with no change (PR = 1.48), newly experiencing unpaid wages compared with no experience (PR = 1.44), insufficient money to buy necessities compared with no shortage (PR = 1.45), receiving a student loan or scholarship compared with none (PR = 1.27), and communication 1 to 3 times a month compared with at least once a week (PR = 1.22). In contrast, school closure during the pandemic compared with no closure was inversely associated with psychological distress (PR = 0.78). Conclusions: Among undergraduate students in Japan, economic difficulties significantly predicted psychological distress.

DOI： 10.1017/dmp.2022.245

Web of Science

Scopus

PubMed

Possible contribution of COVID-19 vaccination to the subsequent mental well-being in Japan 査読有り国際誌

Chiang, CF; Morita, S; Hirakawa, Y; Priya, FT; Matsumoto, Y; Ota, A; Yatsuya, H; Tabuchi, T

SCIENTIFIC REPORTS 12 巻 ( 1 ) 頁： 21195 - 21195 2022年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

The coronavirus disease 2019 (COVID-19) pandemic has had a severe impact on mental well-being. Vaccination may have played a pivotal role in enduring this mental health crisis. The present study aimed to longitudinally investigate the association between COVID-19 vaccination and mental health status among Japanese population in 2021. Longitudinal data of 17,089 individuals aged 15–79 years who participated in a nationwide online study were analyzed. Baseline and follow-up mental health statuses were assessed using the Kessler Psychological Distress Scale (K6). General linear and multivariable logistic regression models adjusted for baseline levels of mental distress were used to examine the association between vaccine receipt and follow-up levels of mental health. Mean K6 scores were lower in the vaccinated than in the non-vaccinated participants. Those who had received one or two doses of COVID-19 vaccines were associated with improved mental health at follow-up in subjects with psychological distress at baseline (odds ratio [OR] 1.31 and 1.35, respectively) and were inversely associated with deteriorated mental health status at follow-up in subjects without psychological distress at baseline (OR 0.66 and 0.70, respectively) compared with no vaccination groups, respectively. The present study would indicate that one or two doses of COVID-19 vaccinations contributed to mental well-being in Japan. This finding might provide evidence for promoting vaccination against COVID-19 and emerging infectious diseases in the future.

DOI： 10.1038/s41598-022-25357-1

Super-additive associations between parity and education level on mortality from cardiovascular disease and other causes: the Japan Collaborative Cohort Study 査読有り国際誌

Yasukawa S., Eguchi E., Tamakoshi A., Iso H., Tamakoshi A., Mori M., Kaneko Y., Tsuji I., Nakamura Y., Yamagishi K., Mikami H., Kurosawa M., Hoshiyama Y., Tanabe N., Tamakoshi K., Wakai K., Ando M., Suzuki K., Hashimoto S., Yatsuya H., Kikuchi S., Wada Y., Okabayashi S., Ozasa K., Mikami K., Sakata K., Kurozawa Y., Fujino Y.

BMC Women's Health 22 巻 ( 1 ) 2022年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMC Women's Health

Background: While women’s parity status and education level have independent associations with cardiovascular and other diseases, no studies have evaluated the additive interaction of these two factors. Therefore, we examined the additive interaction between parity and education level on mortality from stroke, coronary heart disease, total cardiovascular disease, cancer, non-cardiovascular disease, and non-cancer causes, and all causes in Japanese women. Methods: This study followed 41,242 women aged 40–79 years without a history of cardiovascular disease or cancer from 1988 to 1990 until 2009. Baseline parity and education level were classified into four categories, with highly educated parous women as the reference group. Cox proportional hazards regression analyses were performed to calculate the risk of mortality. We also assessed the additive interactions between parity and education level on mortality from cardiovascular disease and other causes using the relative excess risk due to interaction obtained using Cox models. Results: During the median follow-up period of 19.1 years, we identified 6299 deaths. In a multivariable model adjusted for cardiovascular disease and other disease risk factors, nulliparous women with low education levels had increased multivariable-adjusted hazard ratios of 1.67 (95% confidence interval [CI] 1.13, 2.47) for stroke, 1.98 (95% CI 1.15, 3.39) for coronary heart disease, 1.71 (95% CI 1.34,2.18) for total cardiovascular disease, 1.69 (95% CI 1.33, 2.14) for non-cardiovascular and non-cancer, and 1.51 (95% CI 1.30, 1.75) for all-cause mortality when compared with highly educated parous women. Moreover, we observed significant additive interactions between parity and education level on total cardiovascular disease mortality (P = 0.04), non-cardiovascular disease and non-cancer mortality (P = 0.01), and all-cause mortality (P = 0.005). Conclusions: Nulliparity and low education levels are super-additively associated with total cardiovascular disease, non-cardiovascular and non-cancer, and all-cause mortality risks, suggesting that nulliparous women with low education levels need specific support for preventing mortality related to cardiovascular and other diseases.

DOI： 10.1186/s12905-022-01805-y

Scopus

The association of public trust with the utilization of digital contact tracing for COVID-19 in Japan 査読有り国際誌

He, YP; Yatsuya, H; Ota, A; Tabuchi, T

PUBLIC HEALTH IN PRACTICE 4 巻頁： 100279 - 100279 2022年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Public Health in Practice

Objectives: To examin whether public trust was associated with the utilization of COVID-19 Contact Confirming Application (COCOA) in those who self-reported a history of COVID-19. Study design: Cross-sectional study. Methods: Data were obtained from the Japan Society and New Tobacco Internet Survey, a nationwide online survey conducted from February to March 2021, which also assessed items related to COVID-19 and public trust. We included 453 participants with a history of COVID-19. Participants' reports of their general trust in the national government and the related policies, attitudes toward COVID-19 vaccination, and the adherence to the preventive measures against SARS-CoV-2 spread were compared between COCOA users and non-users controlling for age, sex, and socioeconomic statuses by analysis of covariance. Mediation analysis was conducted to examine whether public trust mediates the associations of certain participants’ characteristics with COCOA utilization. Results: Seventy-six percent (344/453) reported the COCOA utilization. Compared to non-users, the users were younger, more likely to be men and had a tendency to have higher education. They were more willing to get COVID-19 vaccination, adherent to public health measures against the spread of the SARS-Cov-2, and more likely to express trust in government in general and policies related to COVID-19 independent of age, sex, and the socioeconomic status. Trust in government did not mediate the associations of age and education with COCOA utilization. Conclusions: The utilization of digital contact tracing technology for the health of public during pandemic was related to the degree of trust in the government in Japan.

DOI： 10.1016/j.puhip.2022.100279

Gender Difference in Fear and Anxiety about and Perceived Susceptibility to COVID-19 in the Third Wave of Pandemic among the Japanese General Population: A Nationwide Web-Based Cross-Sectional Survey 査読有り国際誌

Sasaki, R; Ota, A; Yatsuya, H; Tabuchi, T

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 19 巻 ( 23 ) 2022年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Environmental Research and Public Health

Existing research suggested gender differences in fear and anxiety about and perceived susceptibility to COVID-19 and previous infectious disease pandemics. We analyzed whether women felt fear and anxiety about and perceived susceptibility to COVID-19 more frequently than men in Japan. We conducted a cross-sectional analysis using internet survey data collected during the third wave of the pandemic in Japan. The subjects were enrolled from the Japanese general population: 11,957 men and 11,559 women. Fear and anxiety specifically related to COVID-19 were evaluated with the Japanese version of the Fear of COVID-19 Scale (FoCS). The question “How likely do you think you will be infected with COVID-19?” was used to assess the perceived susceptibility to COVID-19. Women had higher mean (standard deviation) FoCS scores [18.6 (5.6) vs. 17.5 (5.9), d = 0.190] and reported the median or higher FoCS score (57.4% vs. 51.4%, φ = 0.060) and perceived susceptibility (13.6% vs. 11.5%, φ = 0.032) more frequently than men. The odds ratios (95% confidence intervals) adjusted for age, having a spouse, comorbidities, watching commercial TV stations’ news programs, employment status, and household income were 1.24 (1.17–1.32) and 1.27 (1.16–1.38), respectively. We observed that women were more anxious and fearful about and perceived the susceptibility to infectious diseases more frequently than men even one year after the pandemic occurred in Japan, although the effect size was small.

DOI： 10.3390/ijerph192316239

Association between long-term alcohol consumption and insomnia symptoms in civil servants: Aichi Workers' Cohort Study. 査読有り

Terabe M, Kitajima T, Ota A, Yatsuya H, Iwata N

Fujita medical journal 8 巻 ( 4 ) 頁： 103 - 107 2022年11月

Long-term variability and change trend of systolic blood pressure and risk of type 2 diabetes mellitus in middle-aged Japanese individuals: findings of the Aichi Workers' Cohort Study 査読有り国際共著国際誌

Song, ZA; He, YP; Chiang, CF; Al-Shoaibi, AAA; Saif-Ur-Rahman, KM; Mamun, MR; Aoyama, A; Hirakawa, Y; Matsunaga, M; Ota, A; Tamakoshi, K; Li, YY; Yatsuya, H

HYPERTENSION RESEARCH 45 巻 ( 11 ) 頁： 1772 - 1780 2022年11月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Hypertension Research

Studies have reported that short-term blood pressure (BP) variability (BPV) is associated with type 2 diabetes mellitus (T2DM) incidence, but the association with long-term BPV remains unclear. The present study investigated the associations of long-term BPV as well as the time trend of BP changes over time with the incidence of T2DM. This study followed a cohort of 3017 Japanese individuals (2446 male, 571 female) aged 36–65 years from 2007 through March 31, 2019. The root-mean-square error (RMSE) and the slope of systolic BP (SBP) change regressed on year were calculated individually using SBP values obtained from 2003 to baseline (2007). A multivariable Cox proportional hazard model was applied to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for tertiles of SBP RMSE and continuous SBP slopes adjusted for age, sex, smoking status, regular exercise, sodium intake, family history of diabetes, sleep disorder, body mass index (BMI), SBP, and fasting blood glucose (FBG) at baseline, and BMI slope from 2003 to 2007. The highest RMSE tertile compared to the lowest was associated with a significantly higher incidence of T2DM after adjusting for covariates (HR: 1.79, 95% CI: 1.15, 2.78). The slope was also significantly associated with T2DM incidence until baseline SBP and FBG were adjusted (HR: 1.03, 95% CI: 0.99, 1.07). In conclusion, long-term SBP variability was significantly associated with an increased incidence of T2DM independent of baseline age, sex, BMI, SBP, FBG, lifestyle factors and BMI slope from 2003 until baseline.

DOI： 10.1038/s41440-022-00993-2

その他リンク： https://www.nature.com/articles/s41440-022-00993-2

Increased serum anti-CYP2E1 IgG autoantibody levels may be involved in the pathogenesis of occupational trichloroethylene hypersensitivity syndrome: a case-control study 査読有り国際誌

Nakajima, T; Wang, HL; Yuan, Y; Ito, Y; Naito, H; Kawamoto, Y; Takeda, K; Sakai, K; Zhao, N; Li, HL; Qiu, XX; Xia, LH; Chen, JB; Wu, QF; Li, LY; Huang, HL; Yanagiba, Y; Yatsuya, H; Kamijima, M

ARCHIVES OF TOXICOLOGY 96 巻 ( 10 ) 頁： 2785 - 2797 2022年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Archives of Toxicology

Occupational exposure to trichloroethylene (TCE) causes a systemic skin disorder with hepatitis known as TCE hypersensitivity syndrome (TCE-HS). Human Leukocyte Antigen (HLA)-B*13:01 is its susceptibility factor; however, the immunological pathogenesis of TCE-HS remains unknown. We herein examined the hypothesis that autoantibodies to CYP2E1 are primarily involved in TCE-HS. A case–control study of 80 TCE-HS patients, 186 TCE-tolerant controls (TCE-TC), and 71 TCE-nonexposed controls (TCE-nonEC) was conducted to measure their serum anti-CYP2E1 antibody (IgG) levels. The effects of TCE exposure indices, such as 8-h time-weighted-average (TWA) airborne concentrations, urinary metabolite concentrations, and TCE usage duration; sex; smoking and drinking habits; and alanine aminotransferase (ALT) levels on the antibody levels were also analyzed in the two control groups. There were significant differences in anti-CYP2E1 antibody levels among the three groups: TCE-TC > TCE-HS patients > TCE-nonEC. Antibody levels were not different between HLA-B*13:01 carriers and noncarriers in TCE-HS patients and TCE-TC. The serum CYP2E1 measurement suggested increased immunocomplex levels only in patients with TCE-HS. Multiple regression analysis for the two control groups showed that the antibody levels were significantly higher by the TCE exposure. Women had higher antibody levels than men; however, smoking, drinking, and ALT levels did not affect the anti-CYP2E1 antibody levels. Anti-CYP2E1 antibodies were elevated at concentrations lower than the TWA concentration of 2.5 ppm for TCE exposure. Since HLA-B*13:01 polymorphism was not involved in the autoantibody levels, the possible mechanism underlying the pathogenesis of TCE-HS is that TCE exposure induces anti-CYP2E1 autoantibody production, and HLA-B*13:01 is involved in the development of TCE-HS.

DOI： 10.1007/s00204-022-03326-x

Association between irregular daily routine and risk of incident stroke and coronary heart disease in a large Japanese population 査読有り国際誌

Yoshizaki, T; Ishihara, J; Kotemori, A; Kokubo, Y; Saito, I; Yatsuya, H; Yamagishi, K; Sawada, N; Iwasaki, M; Iso, H; Tsugane, S

SCIENTIFIC REPORTS 12 巻 ( 1 ) 頁： 15750 - 15750 2022年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

Circadian misalignments have been linked to adverse cardiometabolic outcomes. However, the association between irregular daily routine and the risk of cardiovascular disease (CVD) remains unknown. We examined this association in a prospective study in Japan. The study included 78,115 Japanese participants aged 45–74 years. The self-reported daily routine was evaluated using the question, ‘Is your daily routine or activity schedule regular?’ The response (yes/no) was obtained as a binary variable. Cox proportional hazard regression analysis was used to estimate the hazard ratios and 95% confidence intervals for the association between an irregular daily routine and CVD incidence risk. Among the participants, 23.7% reported an irregular daily routine. During the mean follow-up period of 13.3 years, we observed 4641 CVD events. An irregular daily routine was significantly associated with increased risks of CVD and total stroke in women, but not in men. This positive association between an irregular daily routine and the risk of CVD was weak in the high vegetable and fruit consuming population. An irregular daily routine is positively associated with the risk of incident CVD, especially in women. These associations may be weak in populations that consume a diet rich in vegetables and fruits.

DOI： 10.1038/s41598-022-20019-8

Diabetes management in people living with dementia in Japan: a qualitative exploration 査読有り国際誌

KM, SUR; HIRANO, Y; HIRAKAWA, Y; YATSUYA, H

PSYCHOGERIATRICS 22 巻 ( 5 ) 頁： 728 - 735 2022年9月

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Psychogeriatrics

Background: Dementia and diabetes are highly prevalent among the older society in Japan. People living with dementia (PLWD) often face hurdles in managing diabetes. This study explored the perspectives of healthcare providers in Japan regarding diabetes management in PLWD. Methods: We conducted a qualitative study using in-depth interviews as a data collection method. A total of 15 physicians and nurses were interviewed. A qualitative content analysis of the codes was performed to generate the themes. Results: The major themes focused on the management of medications/therapeutic regimen, difficulties of continuing health care, emotional aspects of PLWD for adherence to lifestyle modification, and varying direction and degree of family support for diabetes care. Conclusion: PLWD in Japan face challenges in medication management, food restriction, and lifestyle modification. Policies to engage home visit care workers in medication management, consideration of the emotional aspect of PLWD, and utilisation of social support might help in the proper management of diabetes in PLWD.

DOI： 10.1111/psyg.12876

Web of Science

Scopus

PubMed

Secondhand smoke and the risk of incident cardiovascular disease among never-smoking women 査読有り国際誌

Kobayashi, Y; Yamagishi, K; Muraki, I; Kokubo, Y; Saito, I; Yatsuya, H; Iso, H; Tsugane, S; Sawada, N

PREVENTIVE MEDICINE 162 巻頁： 107145 - 107145 2022年9月

母体特性と妊娠中期血清n3系多価不飽和脂肪酸濃度の関連

金子佳世, 伊藤由起, 加藤沙耶香, 榎原毅, 八谷寛, 上島通浩

日本公衆衛生学会総会抄録集 81回巻頁： 207 - 207 2022年9月

A comparative study of the work-family conflicts prevalence, their sociodemographic, family, and work attributes, and their relation to the self-reported health status in Japanese and Egyptian civil workers 査読有り国際共著国際誌

Abd El Latief, OK; Eshak, ES; Mahfouz, EM; Iso, H; Yatsuya, H; Sameh, EM; Ghazawy, ER; Baba, S; Emam, SA; El-khateeb, AS; Hassan, EE

BMC PUBLIC HEALTH 22 巻 ( 1 ) 頁： 1490 2022年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMC Public Health

Background: Cross-cultural studies studying work-family conflicts (W_F_Cs) are scarce. We compared the prevalence of W_F_Cs, factors correlated with them, and their association with self-rated health between Japan and Egypt. Methods: Among 4862 Japanese and 3111 Egyptian civil workers recruited by a convenience sample in 2018/2019 and reported self-rated health status, we assessed the W_F_Cs by the Midlife Development in the US (MIDUS) and attributed them to sociodemographic, family, and work variables. We also evaluated the W_F_Cs’ gender- and country-specific associations with self-rated health by logistic regression analyses. Results: W_F_Cs were more prevalent in Egyptian than in Japanese women (23.7% vs. 18.2%) and men (19.1% vs. 10.5%), while poor self-rated health was more prevalent in Japanese than Egyptians (19.3% and 17.3% vs. 16.9% and 5.5%). Longer working hours, shift work, and overtime work were positively associated with stronger work-to-family conflict (WFC). Whereas being single was inversely associated with stronger family-to-work conflict (FWC). Living with children, fathers, or alone in Japan while education in Egypt was associated with these conflicts. The OR (95% CI) for poor self-reported health among those with the strong, in reference to weak total W_F_Cs, was 4.28 (2.91–6.30) and 6.01 (4.50–8.01) in Japanese women and men and was 2.46 (1.75–3.47) and 3.11 (1.67–5.80) in Egyptian women and men. Conclusions: Japanese and Egyptian civil workers have different prevalence and correlated factors of W_F_Cs and self-rated health. W_F_Cs were associated in a dose–response pattern with poor-self-rated health of civil workers in both countries.

DOI： 10.1186/s12889-022-13924-0

その他リンク： https://link.springer.com/article/10.1186/s12889-022-13924-0/fulltext.html

[Impact of the COVID-19 pandemic on national and prefectural health and nutrition examination surveys: A report by the Monitoring Report Committee of the Japanese Society of Public Health]. 査読有り

Kubo A, Kuno K, Maruyama K, Tsukinoki R, Noda H, Egawa K, Shibuya I, Sei M, Chihara M, Nishina K, Yatsuya H

[Nihon koshu eisei zasshi] Japanese journal of public health 69 巻 ( 8 ) 頁： 586 - 594 2022年8月

担当区分：最終著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本公衆衛生学会

目的　新型コロナウイルス感染症の蔓延により2020年度および2021年度の国民健康・栄養調査が中止され，都道府県の調査も中止または延期が予想されたため，日本公衆衛生学会公衆衛生モニタリング・レポート委員会生活習慣病・公衆栄養グループでは都道府県民健康・栄養調査の実施状況を調査し，公衆衛生施策立案のために必要なデータ収集の現状と課題を検討した。方法　47都道府県の調査担当者を対象に，郵送もしくは電子媒体による自記式質問紙調査を実施した。結果　47都道府県（回収率100％）から回答が得られた。健康・栄養調査を実施しているのは44自治体（93.6％）であった。新型コロナウイルス感染症の影響から2020年度調査予定の18自治体のうち「予定通りの内容で実施した」は2（11.1％）「中止した」は16（88.9％）であった。2021年度調査予定の31自治体のうち「予定通りの内容で実施した」は4（12.9％）「内容を一部変更して実施した」は5（16.1％）「中止した」は22（71.0％）であった。今後の調査方法について，身体状況調査実施の32自治体のうち「変更する予定はない」は6（18.8％）「未定」は18（56.3％）であった。栄養摂取状況調査実施の40自治体のうち「変更する予定はない」は12（30.0％）「未定」は19（47.5％）であった。2か年とも調査を中止した13自治体の各種計画評価は「各種計画期間を延長する」8（61.5％）「その他」7（53.8％）であった。2か年に調査を中止または延期した38自治体のうち，各種計画評価に関する問題点は「調査法の変更に伴う経年評価が不可能になる」「コロナ禍でのライフスタイル変化の影響が想定される」「評価に影響はないが評価期間が短縮となる」「国民健康・栄養調査中止により全国比較が不可能である」等があげられた。結論　都道府県健康増進計画等の評価のため，ほとんどの自治体が都道府県民健康・栄養調査を実施していた。また，全国比較ができるよう国民健康・栄養調査と同じ方式で実施する自治体が多かった。新型コロナウイルス感染症の影響により，国民健康・栄養調査と同様に調査を中止する都道府県が多く，今後の調査も未定と回答する自治体が多かった。

DOI： 10.11236/jph.22-020

PubMed

CiNii Research

Dietary Patterns Derived from Reduced Rank Regression Are Associated with the 5-Year Occurrence of Metabolic Syndrome: Aichi Workers' Cohort Study 査読有り国際誌

Li, YY; Yatsuya, H; Wang, CC; Uemura, M; Matsunaga, M; He, YP; Khine, M; Ota, A

NUTRIENTS 14 巻 ( 15 ) 頁： 3019 - 3019 2022年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nutrients

The aim of the present study was to derive dietary patterns to explain variation in a set of nutrient intakes or in the measurements of waist circumference (WC) and fasting blood glucose (FBG) using reduced rank regression (RRR) and to prospectively investigate these patterns in relation to the risk of developing metabolic syndrome (MetS) and its components during the follow-up. The study participants were comprised of 2944 government employees aged 30–59 years without MetS. RRR was applied with 38 food groups as predictors and with two sets of response variables. The first set included intake of putatively beneficial nutrients, and the first factor retained was named the Healthy Dietary Pattern (HDP). The second one included baseline WC and FBG, and the first factor was named the Unhealthy Dietary Pattern (UHDP). Multivariable Cox proportional hazard model was used to estimate hazard ratio and 95% confidence intervals with adjustments for age, sex, total energy consumption and other potential confounders. During the 5-year median follow-up, we ascertained 374 cases of MetS. The HDP score was inversely associated with the incidence of MetS (p-trend = 0.009) and hypertension (p-trend = 0.002) and marginally significantly associated with elevated triglyceride and decreased high-density lipoprotein cholesterol (p-trend = 0.08). The UHDP score was linearly positively associated with the incidence of MetS and all its components (all p-trend < 0.05). Both the HDP and UHDP predicted the development of MetS and its components.

DOI： 10.3390/nu14153019

Combined Exoscopic and Endoscopic Two-Step Keyhole Approach for Intracranial Meningiomas 査読有り国際誌

Watanabe, T; Iwami, K; Kishida, Y; Nagatani, T; Yatsuya, H; Miyachi, S

CURRENT ONCOLOGY 29 巻 ( 8 ) 頁： 5370 - 5382 2022年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Current Oncology

The advantages of neuroendoscopic surgery are the wide viewing angle and the freedom of an axis of view with minimal surgical trauma. With the advent of the exoscope, which has similar advantages to endoscopy, such as a small body and ergonomically superior heads-up surgery, it has become possible to add a field of view that is similar to that of microsurgery to endoscopic surgery. By taking advantage of the features of these scopes, we report the usefulness of the minimally invasive combined exoscopic and endoscopic two-step keyhole approach (EEKA) for various types of meningiomas. We reviewed data from 34 consecutive cases of EEKA for various types of intracranial meningiomas compared with that of conventional microsurgery. All of the tumors were resected as planned without severe complications. Significantly better outcome data were obtained in terms of the blood loss and the surgical time in the EEKA group, in addition to the craniotomy size. The well-illuminated fine vision in the deep corners by the endoscope enabled radical resection of the tumors with minimum burden on the patients. This technique has the potential for minimally invasive surgery in intracranial meningioma patients, including the older population.

DOI： 10.3390/curroncol29080426

Influence of the COVID-19 pandemic on regular clinic visits and medication prescriptions among people with diabetes: Retrospective cohort analysis of health care claims 査読有り国際誌

Maeda, T; Nishi, T; Harada, M; Tanno, K; Nishiya, N; Asayama, K; Okuda, N; Sugiyama, D; Yatsuya, H; Okayama, A; Arima, H

MEDICINE 101 巻 ( 29 ) 頁： e29458 2022年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Medicine (United States)

The aim of this study was to investigate the effect of the COVID-19 pandemic on regular clinic visits among people with diabetes and to elucidate the factors related to visit patterns among these patients during the pandemic. This was a longitudinal study using anonymized insurance claims data from the Joint Health Insurance Society in Tokyo from October 2017 to September 2020. First, we identified patients with diabetes who were fully enrolled in the health plan from fiscal year 2017 until September 2020 and who were regularly receiving glucose-lowering medications (every 1-3 months) from October 2017 to September 2018. We divided follow-up into the pre-pandemic period (October 2018 to March 2020) and the pandemic period (April 2020 to September 2020). A multilevel logistic regression model was used to determine the risks of delayed clinic visits/medication prescriptions (i.e., >3 months after a previous visit/prescription) during the pandemic period. We identified 1118 study participants. The number of delayed clinic visits/medication prescriptions during the pre-pandemic and pandemic periods was 188/3354 (5.6%) and 125/1118 (11.2%), respectively. There was a significant increase in delayed clinic visits during the pandemic (adjusted odds ratio 3.68 (95% confidence interval 2.24 to 6.04, P <.001), even after controlling for confounding factors. We also found a significant interaction between sex and delayed visits; women had significantly fewer clinic visits during the COVID-19 pandemic than men. We clarified the relationship of the COVID-19 pandemic with delays in regular clinic visits and medication prescriptions among people with diabetes. The response to the COVID-19 pandemic differed between men and women.

DOI： 10.1097/MD.0000000000029458

High Maternal Total Cholesterol Is Associated With No-Catch-up Growth in Full-Term SGA Infants: The Japan Environment and Children's Study 査読有り国際誌

Kaneko, K; Ito, Y; Ebara, T; Kato, S; Matsuki, T; Tamada, H; Sato, H; Saitoh, S; Sugiura-Ogasawara, M; Yatsuya, H; Kamijima, M; Grp

FRONTIERS IN ENDOCRINOLOGY 13 巻頁： 939366 - 939366 2022年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Frontiers in Endocrinology

Objectives: Infants born small for gestational age (SGA) with no catch-up growth (No-CU) are at high risk of intellectual and developmental disabilities. However, factors leading to No-CU among SGA infants are unclear. This study aimed to examine the association between maternal total cholesterol (TC) in mid-pregnancy and No-CU at 3 years among full-term SGA infants. Study Design: The Japan Environment and Children’s Study (JECS) is a nationwide prospective birth cohort study. We extracted a total of 2,222 mothers and full-term SGA infants (length and/or weight <‐2 standard deviation [SD]) without congenital abnormalities from the original JECS cohort comprising a total of 104,062 fetal records. According to the distribution of maternal TC in the entire cohort, participants were classified into nine groups per each fifth percentile with the 20th–79th percentiles (204–260 mg/dl) as the reference group. No-CU was defined by a Z-score of height at 3 years <‐2 SD according to the growth standard charts for Japanese children. Multivariable-adjusted logistic regression models were carried out using multiple imputations. Additionally, a multiple-adjusted restricted cubic spline model was performed in the complete dataset. Results: A total of 362 (16.3%) children were No-CU at 3 years. After adjusting for the Z-score of birth weight, age of mother, smoking status, weight gain during pregnancy, breastfeeding and meal frequency at 2 years, and parents’ heights, the odds ratio (95% confidence intervals) of No-CU was 2.95 (1.28–6.80) for children whose maternal TC levels were in the highest category (≥294 mg/dl), compared to the reference group. A multiple-adjusted restricted cubic spline model showed a non-linear trend of the significant association between high maternal TC and No-CU (p for linear trend = 0.05, p for quadratic trend <0.05). Conclusion: High maternal TC at mid-pregnancy was associated with No-CU among SGA infants. Such infants should be carefully followed up to introduce appropriate growth hormonal treatment. The findings may support previous animal experimental studies which indicated that maternal high-fat diet exposure induces impairment of growth and skeletal muscle development in the offspring. Future studies are required to elucidate the detailed mechanism.

DOI： 10.3389/fendo.2022.939366

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