研究者詳細 - 八谷　寛

論文 - 八谷　寛

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日本人男性における血清レプチン濃度と5年間追跡後の体重変化. 招待有り

八谷寛, 玉腰浩司, 大塚礼, 間淵智子, 和田恵子, 張恵明, 村田千代栄, 石川美由紀, 近藤高明, 豊嶋英明.

健康医科学研究助成論文集 19 巻頁： 110-117 2004年

肥満者における心血管疾患発症の過剰リスクを説明する新しい軸－血清レプチン値と白血球数の関連－招待有り

八谷寛, 淵智子, 大塚礼, 和田恵子, 長澤伸江, 張恵明, 村田千代栄, 石川美由紀, 堀容子, 近藤高明, 玉腰浩司, 豊嶋英明.

健康管理事業団研究助成論文集 10 巻頁： 19-25 2004年

Individual and joint impact of family history and Helicobacter pylori infection on the risk of stomach cancer: a nested case-control study. 査読有り

Yatsuya H, Toyoshima H, Tamakoshi A, Kikuchi S, Tamakoshi K, Kondo T, Mizoue T, Tokui N, Hoshiyama Y, Sakata K, Hayakawa N, Yoshimura T; Japan Collaborative Cohort Study Group.

British Journal of Cancer 91 巻 ( 5 ) 頁： 929-934 2004年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

We used 202 cases of stomach cancer and 394 controls nested within the Japan Collaborative Cohort Study For Evaluation of Cancer Risk (JACC study) to investigate whether family history has an independent effect on the risk of stomach cancer after controlling for the Helicobacter pylori infection. A positive history of stomach cancer in one or more first-degree relatives was associated with an increased risk of the disease in women, but not in men after controlling for H. pylori infection and other confounding variables. Women with both a family history and H. pylori infection were associated with more than five-fold increased risk of the disease (OR 5.10, 95% CI 1.58-16.5) compared to those without these factors. These results suggest the existence of inherited susceptibility to the disease in women, and that measurements of H. pylori infection together with the family history allow meaningful evaluation of risk beyond that provided by either factor alone.

Serum phospholipid transfer protein mass as a possible protective factor for coronary heart diseases. 査読有り

Yatsuya H, Tamakoshi K, Hattori H, Otsuka R, Wada K, Zhang H, Mabuchi T, Ishikawa M, Murata C, Yoshida T, Kondo T, Toyoshima H.

Circulation Journal 68 巻 ( 1 ) 頁： 11-16 2004年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Phospholipid transfer protein (PLTP) can generate pre-beta high-density lipoprotein (HDL), an efficient acceptor of peripheral cholesterol, by mediating a process called HDL conversion. The transfer of phospholipids to immature HDL is also essential in maintaining reverse cholesterol transport. The phospholipid transfer activity of PLTP has been associated with various patho-physiological conditions; however, little information is available concerning the relationship between PLTP mass and disease. METHODS AND RESULTS: Using a sandwich enzyme-linked immunosorbent assay, PLTP concentration was measured and related to the risk of developing cardiovascular disease in a worksite-based cohort of Japanese men (n=2,567). Multiple linear regression analysis showed significant associations between PLTP and HDL cholesterol, triglycerides, low-density lipoprotein cholesterol, and body mass index (standardized beta=0.395, -0.191, -0.064, and -0.064, respectively; R(2)=0.31). During the follow-up period, there were 10 cases of coronary heart disease (CHD) and 7 of stroke. The multivariate adjusted relative risk of CHD was 0.46 (95% confidence interval, 0.20-1.07) for an increase of 1 standard deviation in the PLTP value (p=0.071). PLTP concentration was not related to the risk of stroke. CONCLUSIONS: The results of this prospective study indicate that the serum PLTP concentration would serve as a predictor of CHD, independent of HDL cholesterol, triglycerides and other established risk factors.

A nested case-control study of stomach cancer in relation to green tea consumption in Japan. 査読有り

Hoshiyama Y, Kawaguchi T, Miura Y, Mizoue T, Tokui N, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Tamakoshi A, Ohno Y, Yoshimura T; Japan Collaborative Cohort Study Group.

Br J Cancer 90 巻 ( 1 ) 頁： 135-8 2004年

A prospective study of body size and colon cancer mortality in Japan: The JACC Study. 査読有り

Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki K, Ito Y, Tamakoshi A; JACC Study Group.

Int J Obes Relat Metab Disord 28 巻 ( 4 ) 頁： 551-8 2004年

A prospective study on the possible association between having children and colon cancer risk: findings from the JACC Study. 査読有り

Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki K, Ito Y, Tamakoshi A; JACC Study Group.

Cancer Sci 95 巻 ( 3 ) 頁： 243-7 2004年

A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women: findings from the JACC study. 査読有り

Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki K, Suzuki S, Kawado M, Ozasa K, Ito Y, Tamakoshi A; JACC Study Group.

Cancer Sci 95 巻 ( 7 ) 頁： 602-7 2004年

肥満女性と結腸癌招待有り

医学のあゆみ 208 巻頁： 229-230 2004年

人間ドックの有効性と限界招待有り

玉腰浩司, 八谷寛, 豊嶋英明.

総合臨床 53 巻頁： 2435-2438 2004年

Association of flatfoot with pain, fatigue and obesity in Japanese over sixties. 査読有り

Otsuka R, Yatsuya H, Miura Y, Murata C, Tamakoshi K, Oshiro K, Nishio N, Ishikawa M, Zhang HM, Shiozawa M, Kobayashi A, Ito M, Hori Y, Kondo T, Toyoshima H.

Nippon Koshu Eisei Zasshi 50 巻 ( 10 ) 頁： 988-98 2003年10月

Effect of tactile interference stimulation of the ear in human primary somatosensory cortex: a magnetoencephalographic study. 査読有り

Nihashi T, Kakigi R, Hoshiyama M, Miki K, Kajita Y, Yoshida J, Yatsuya H.

Clin Neurophysiol 114 巻 ( 10 ) 頁： 1866-78 2003年10月

Long-term body weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese men. 査読有り

Tamakoshi K, Yatsuya H, Kondo T, Ishikawa M, Zhang H, Murata C, Otsuka R, Mabuchi T, Hori Y, Zhu S, Yoshida T, Toyoshima H.

Int J Obes Relat Metab Disord 27 巻 ( 9 ) 頁： 1059-65 2003年9月

Aggregation of stomach cancer history in parents and offspring in comparison with other sites. 査読有り

Kondo T, Toyoshima H, Tsuzuki Y, Hori Y, Yatsuya H, Tamakoshi K, Tamakoshi A, Ohno Y, Kikuchi S, Sakata K, Hoshiyama Y, Hayakawa N, Tokui N, Mizoue T, Yoshimura T.

Int J Epidemiol 頁： 579-83 2003年8月

Prospective study of screening for stomach cancer in Japan. 査読有り

Mizoue T, Yoshimura T, Tokui N, Hoshiyama Y, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Tamakoshi A, Ohno Y, Fujino Y, Kaneko S; Japan Collaborative Cohort Study Group.

Int J Cancer 106 巻 ( 1 ) 頁： 103-7 2003年8月

The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state. 査読有り

Tamakoshi K, Yatsuya H, Kondo T, Hori Y, Ishikawa M, Zhang H, Murata C, Otsuka R, Zhu S, Toyoshima H.

Int J Obes Relat Metab Disord 27 巻 ( 4 ) 頁： 443-9 2003年4月

U-shaped association between white blood cell count and fasting plasma glucose level. 査読有り

Tamakoshi K, Yatsuya H, Kondo T, Hori Y, Zhang H, Ishikawa M, Murata C, Otsuka R, Zhu S, Toyoshima H.

Diabetes Care 26 巻 ( 3 ) 頁： 950 2003年3月

The accuracy of long-term recall of past body weight in Japanese adult men. 査読有り

Tamakoshi K, Yatsuya H, Kondo T, Hirano T, Hori Y, Yoshida T, Toyoshima H.

Int J Obes Relat Metab Disord 27 巻 ( 2 ) 頁： 247-52 2003年2月

Gender and age differences in lifestyle factors related to hypertension in middle-aged civil service employees. 査読有り

Hori Y, Toyoshima H, Kondo T, Tamakoshi K, Yatsuya H, Zhu S, Kawamura T, Toyama J, Okamoto N.

J Epidemiol 13 巻 ( 1 ) 頁： 38-47 2003年1月

Reproducibility and validity of a simple checklist-type questionnaire for food intake and dietary behavior. 査読有り

Yatsuya H, Ohwaki A, Tamakoshi K, Wakai K, Koide K, Otsuka R, Mabuchi T, Murata C, Zhang H, Ishikawa M, Kondo T, Toyoshima H.

Journal of Epidemiology 13 巻 ( 5 ) 頁： 235-245 2003年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: A simple, reliable, and valid food questionnaire is needed in clinical dietary assessments, community health education, and multi-purpose epidemiologic studies to obtain a crude measure of dietary intake. METHODS: To assess the validity and reproducibility of a simple 4-point scale food intake and behavior checklist, it was compared to two 3-day weighed dietary records. The FBC was administered to 47 students of a dietician course and their parents (n = 94) over a 9-month interval to assess the reproducibility. The mean intakes of selected food groups assessed by the two dietary records completed between food intake and behavior checklists were compared to the responses to the food intake and behavior checklist to assess its validity. RESULTS: The kappa statistics for reproducibility ranged from 0.25 for confectionaries to 0.63 for a preference for fatty foods (median, 0.39). There was a reasonable level of correlation between the dietary record and the food intake and behavior checklist in the intake of eggs, milk, and fruits (r = 0.53, 0.56, and 0.50, respectively). There was a weaker but still significant correlation in the intake of vegetables, and alcohol (r = 0.31 and 0.45, respectively). No significant correlation was observed in the intake of meat, fish, confectionaries, and soft drinks. However, those who reported consuming mainly fish rather than meat were found to eat significantly less meat and animal fat. Similarly, those who did not prefer fatty foods consumed significantly less meat, animal fat, and polyunsaturated fatty acids. CONCLUSIONS: This simple food checklist was useful in collecting data on egg, milk, and fruit consumption. Assessing intake frequency of vegetables, meat or fish with the FBC may be useful in screening high- or low-intake individuals.

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