研究者詳細 - 八谷　寛

論文 - 八谷　寛

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Habitual tub bathing and risks of incident coronary heart disease and stroke 査読有り国際誌

Ukai, T; Iso, H; Yamagishi, K; Saito, I; Kokubo, Y; Yatsuya, H; Muraki, I; Eshak, ES; Sawada, N; Tsugane, S

HEART 106 巻 ( 10 ) 頁： 732 - 737 2020年5月

ウルソデオキシコール酸添加による高脂肪食誘導性肝炎・線維化の軽減作用

内藤久雄, 北森一哉, 橋本沙幸, 浅野友美, 八谷寛, 那須民江

産業衛生学雑誌 62 巻 ( 臨増 ) 頁： 610 - 610 2020年5月

降圧薬ヒドララジンは高脂肪食摂取した高血圧ラットの肝線維化を抑制する

内藤久雄, 袁媛, 北森一哉, 橋本沙幸, 浅野友美, 八谷寛, 那須民江

日本衛生学雑誌 75 巻 ( Suppl. ) 頁： S161 - S161 2020年3月

トリクロロエチレン曝露によるCYP2E1抗体の上昇とその影響因子

那須民江, 王海蘭, 袁媛, 内藤久雄, 伊藤由起, 柳場由絵, 八谷寛, 上島通浩

産業衛生学雑誌 62 巻 ( 2 ) 頁： 105 - 105 2020年3月

労働者の生活習慣指導のありかた特定健康診査による保健指導レベルと2型糖尿病発症の関連およびその人口寄与危険割合愛知職域コホート研究

金子佳世, 八谷寛, 李媛英, 上村真由, 江啓発, 平川仁尚, 内藤久雄, 太田充彦, 玉腰浩司, 青山温子

産業衛生学雑誌 62 巻 ( 2 ) 頁： 94 - 94 2020年3月

Human herpesvirus-6B infection in pediatric allogenic hematopoietic stem cell transplant patients: Risk factors and encephalitis 査読有り国際誌

Miura, H; Kawamura, Y; Hattori, F; Tanaka, M; Kudo, K; Ihira, M; Yatsuya, H; Takahashi, Y; Kojima, S; Sakaguchi, H; Yoshida, N; Hama, A; Yoshikawa, T

TRANSPLANT INFECTIOUS DISEASE 22 巻 ( 1 ) 頁： e13203 2020年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Transplant Infectious Disease

Background: Human herpesvirus-6B (HHV-6B) infection after allogenic hematopoietic stem cell transplantation (allo-HSCT) is known to be associated with post-transplant limbic encephalitis in adults. Meanwhile, the association between HHV-6B infection and central nervous system complications remains unclear in pediatric allo-HSCT patients. Methods: In this study, HHV-6B infection was monitored for more than 50 days after HSCT using virus isolation and real-time PCR. Clinical information such as patient background and encephalitis status was collected retrospectively from medical records. Risk factors for HHV-6B infection were determined by the Cox proportional hazards model, and the clinical features of HHV-6B encephalitis in pediatric allo-HSCT patients were elucidated. Results: Human herpesvirus-6B infection was observed in 74 (33.8%) of 219 patients at 3-47 days (median 18, interquartile range 13-20). Risk factors identified in multivariable analysis were hematological malignancy (hazards ratio [HR], 5.0; 95% confidence interval [CI], 2.3/12.5; P <.0001), solid tumor (HR, 4.8; CI, 1.5/16.3; P =.0104), unrelated donor (HR, 2.1; CI, 1.0/4.6; P =.0378), and sex-mismatched donor (HR 1.8; CI, 1.1/3.0; P =.0257). HHV-6B encephalitis occurred in only one of the 219 patients (0.46%); this patient demonstrated the typical clinical course of posterior reversible encephalopathy syndrome. Conclusion: Hematological malignancy, solid tumor, unrelated donor, and sex-mismatched donor were significant risk factors for HHV-6B infection after pediatric allo-HSCT. In pediatric allo-HSCT patients, the incidence of HHV-6B encephalitis was low and the clinical features differed from those in adult patients.

DOI： 10.1111/tid.13203

Association of Vegetable, Fruit, and Okinawan Vegetable Consumption With Incident Stroke and Coronary Heart Disease 査読有り

Yoshizaki, T; Ishihara, J; Kotemori, A; Yamamoto, J; Kokubo, Y; Saito, I; Yatsuya, H; Yamagishi, K; Sawada, N; Iwasaki, M; Iso, H; Tsugane, S

JOURNAL OF EPIDEMIOLOGY 30 巻 ( 1 ) 頁： 37 - 45 2020年1月

Non-High-Density Lipoprotein Cholesterol and Risk of Stroke Subtypes and Coronary Heart Disease The Japan Public Health Center-Based Prospective (JPHC) Study 査読有り

Saito, I; Yamagishi, K; Kokubo, Y; Yatsuya, H; Iso, H; Sawada, N; Inoue, M; Tsugane, S

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 27 巻 ( 4 ) 頁： 363 - 374 2020年

Depressive Tendency and the Risk of Death from Pneumonia: The JACC Study 査読有り

Tanabe, N; Seki, N; Horikawa, C; Yatsuya, H; Yamagishi, K; Iso, H; Ukawa, S; Tamakoshi, A

INTERNAL MEDICINE 59 巻 ( 24 ) 頁： 3123 - 3130 2020年

Cross-sectional association between working and depression prevalence in cancer survivors: a literature review 査読有り国際誌

Atsuhiko Ota, Kenji Kawada, Akizumi Tsutsumi, Hiroshi Yatsuya

Environmental and Occupational Health Practice 2 巻 ( 1 ) 頁： n/a - n/a 2020年

Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study 査読有り国際誌

Murai, U; Yamagishi, K; Sata, M; Kokubo, Y; Saito, I; Yatsuya, H; Ishihara, J; Inoue, M; Sawada, N; Iso, H; Tsugane, S

AMERICAN JOURNAL OF CLINICAL NUTRITION 110 巻 ( 6 ) 頁： 1449 - 1455 2019年12月

Association Between Body Mass Index and All-Cause Death in Japanese Population: Pooled Individual Participant Data Analysis of 13 Cohort Studies 査読有り

Hozawa, A; Hirata, T; Yatsuya, H; Murakami, Y; Kuriyama, S; Tsuji, I; Sugiyama, D; Satoh, A; Tanaka-Mizuno, S; Miura, K; Ueshima, H; Okamura, T

JOURNAL OF EPIDEMIOLOGY 29 巻 ( 12 ) 頁： 457 - 463 2019年12月

Diagnostic contribution of cytological examination to endobronchial ultrasound-guided transbronchial biopsy for lung malignancies 査読有り

Kajikawa, S; Imai, N; Okachi, S; Yatsuya, H; Souma, T; Watanabe, T; Goto, Y; Minezawa, T; Hashimoto, N; Imaizumi, K; Hasegawa, Y

NAGOYA JOURNAL OF MEDICAL SCIENCE 81 巻 ( 4 ) 頁： 613 - 620 2019年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nagoya Journal of Medical Science

Although endobronchial ultrasound guided transbronchial biopsy (TBB) with a guide sheath (EBUSGS) is widely used for diagnosis of peripheral pulmonary lesions, the diagnostic contribution of cytology (bronchial brushing, bronchial washing and biopsy forceps rinse) has not been established. To determine the diagnostic contribution of cytological examination to EBUS-GS-TBB, we reviewed medical records of patients with lung malignancies who had undergone TBB with EBUS-GS (EBUS-GS group, n=187) or TBB without EBUS-GS (conventional TBB [CTBB] group, n=197) at Nagoya University Hospital. Although the mean size of target lesions was significantly larger in the CTBB group than the EBUS-GS group, the total diagnostic rate was equivalent between two groups (EBUS-GS: 73.3%, CTBB: 66.0%). In the EBUS-GS group, cytological procedures increased the diagnostic rate by 9.1% (17/137), compared with only 4.1% (8/130) in the CTBB group. Sensitivity of cytology among biopsy-negative patients was significantly higher in EBUS-GS group than CTBB group (P=0.022). Furthermore, in the EBUS-GS group, among 17 patients whose malignant diagnoses could only be established cytologically, bronchial brushing contributed to the malignant diagnosis in 64.7% (11/17). These data may suggest that cytological examination, especially bronchial brushing, may be an important diagnostic contributor in EBUS-GS-TBB.

DOI： 10.18999/nagjms.81.4.613

Comparing different definitions of prediabetes with subsequent risk of diabetes: an individual participant data meta-analysis involving 76 513 individuals and 8208 cases of incident diabetes 査読有り国際共著国際誌

Lee, CMY; Colagiuri, S; Woodward, M; Gregg, EW; Adams, R; Azizi, F; Gabriel, R; Gill, TK; Gonzalez, C; Hodge, A; Jacobs, DR ; Joseph, JJ; Khalili, D; Magliano, DJ; Mehlig, K; Milne, R; Mishra, G; Mongraw-Chaffin, M; Pasco, JA; Sakurai, M; Schreiner, PJ; Selvin, E; Shaw, JE; Wittert, G; Yatsuya, H; Huxley, RR

BMJ OPEN DIABETES RESEARCH & CARE 7 巻 ( 1 ) 頁： e000794 2019年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMJ Open Diabetes Research and Care

Objective There are currently five widely used definition of prediabetes. We compared the ability of these to predict 5-year conversion to diabetes and investigated whether there were other cut-points identifying risk of progression to diabetes that may be more useful. Research design and methods We conducted an individual participant meta-analysis using longitudinal data included in the Obesity, Diabetes and Cardiovascular Disease Collaboration. Cox regression models were used to obtain study-specific HRs for incident diabetes associated with each prediabetes definition. Harrell's C-statistics were used to estimate how well each prediabetes definition discriminated 5-year risk of diabetes. Spline and receiver operating characteristic curve (ROC) analyses were used to identify alternative cut-points. Results Sixteen studies, with 76 513 participants and 8208 incident diabetes cases, were available. Compared with normoglycemia, current prediabetes definitions were associated with four to eight times higher diabetes risk (HRs (95% CIs): 3.78 (3.11 to 4.60) to 8.36 (4.88 to 14.33)) and all definitions discriminated 5-year diabetes risk with good accuracy (C-statistics 0.79-0.81). Cut-points identified through spline analysis were fasting plasma glucose (FPG) 5.1 mmol/L and glycated hemoglobin (HbA1c) 5.0% (31 mmol/mol) and cut-points identified through ROC analysis were FPG 5.6 mmol/L, 2-hour postload glucose 7.0 mmol/L and HbA1c 5.6% (38 mmol/mol). Conclusions In terms of identifying individuals at greatest risk of developing diabetes within 5 years, using prediabetes definitions that have lower values produced non-significant gain. Therefore, deciding which definition to use will ultimately depend on the goal for identifying individuals at risk of diabetes.

DOI： 10.1136/bmjdrc-2019-000794

Television Viewing Time and Breast Cancer Incidence or Japanese Premenopausal and Postmenopausal Women: The JACC Study 査読有り

Cao, JH; Eshak, ES; Liu, KY; Muraki, I; Cui, RZ; Iso, H; Tamakoshi, A; Mori, M; Kaneko, Y; Tsuji, I; Nakamura, Y; Yamagishi, K; Mikami, H; Kurosawa, M; Hoshiyama, Y; Tanabe, N; Tamakoshi, K; Wakai, K; Tokudome, S; Suzuki, K; Hashimoto, S; Yatsuya, H; Kikuchi, S; Wada, Y; Kawamura, T; Watanabe, Y; Ozasa, K; Mikami, K; Date, C; Sakata, K; Yoshimura, T; Fujino, Y; Shibata, A; Okamoto, N; Shio, H; Kurozawa, Y

CANCER RESEARCH AND TREATMENT 51 巻 ( 4 ) 頁： 1509 - 1517 2019年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Cancer Research and Treatment

Purpose The evidence on effects of TV viewing time among premenopausal and postmenopausal women for breast cancer risk remains controversial and limited. Materials and Methods A prospective study encompassing 33,276 (17,568 premenopausal, and 15,708 postmenopausal) women aged 40-79 years in whom TV viewing time, menstrual, and reproductive histories were determined by a self-administered questionnaire. The follow-up was from 1988 to 2009 and hazard ratios (HRs) with 95% confidence intervals (CIs) of breast cancer incidence were calculated for longer TV viewing time in reference to shorter TV viewing time by Cox proportional hazard models. Results During 16.8-year median follow-up, we found positive associations between TV viewing time and breast cancer incidence with a borderline significant trend among total women and a significant trend among postmenopausal women. Among total women, the multivariable HRs (95% CIs) for risk of breast cancer in reference to < 1.5 hr/day of TV viewing time were 0.89 (0.59-1.34) for 1.5 to < 3.0 hr/day, 1.19 (0.82-1.74) for 3.0 to < 4.5 hr/day, and 1.45 (0.91-2.32) for ≥ 4.5 hr/day (p for trend=0.053) and among postmenopausal women, the corresponding risk estimates were 1.10 (0.42-2.88), 2.54 (1.11-5.80), and 2.37 (0.92-6.10) (p for trend=0.009), respectively. Conclusion Prolonged TV viewing time was associated with increased risk of breast cancer, especially among postmenopausal women.

DOI： 10.4143/crt.2018.705

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The association between weight fluctuation and all-cause mortality A systematic review and meta-analysis 査読有り国際共著国際誌

Zhang, Y; Hou, FF; Li, JX; Yu, HY; Li, L; Hu, SL; Shen, GD; Yatsuya, H

MEDICINE 98 巻 ( 42 ) 頁： e17513 2019年10月

メタボリックシンドローム、空腹時血糖、腹囲身長比による6年後の2型糖尿病発症予測能査読有り

金子佳世, 八谷寛, 李媛英, 江啓発, 平川仁尚, 太田充彦, 玉腰浩司, 青山温子

日本公衆衛生学会総会抄録集 78回巻頁： 220 - 220 2019年10月

メタボリックシンドローム、空腹時血糖、腹囲身長比による6年後の2型糖尿病発症予測能

金子佳世, 八谷寛, 李媛英, 江啓発, 平川仁尚, 太田充彦, 玉腰浩司, 青山温子

日本公衆衛生学会総会抄録集 78回巻頁： 220 - 220 2019年10月

Body Mass Index and Risks of Incident Ischemic Stroke Subtypes: The Japan Public Health Center-Based Prospective (JPHC) Study. 査読有り国際誌

Li Y, Yatsuya H, Iso H, Yamagishi K, Saito I, Kokubo Y, Sawada N, Tsugane S

Journal of epidemiology 29 巻 ( 9 ) 頁： 325 - 333 2019年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Epidemiology

Background: The association of body mass index (BMI) with risks of ischemic stroke subtypes have not been established. Methods: Cumulative average BMI was calculated using self-reported body weight and height obtained from baseline (Cohort I in 1990, and Cohort II from 1993-1994) and 5- and 10-year questionnaire surveys of Japan Public Health Center-based prospective (JPHC) study. A total of 42,343 men and 46,413 women aged 40-69 years were followed-up for the incidence of lacunar, large-artery occlusive, and cardioembolic strokes. A sub-distribution hazard model was used to estimate subdistribution hazard ratios (SHRs) and the 95% confidence intervals (CIs). Results: During a median of 20.0 years of follow-up, we documented 809 and 481 lacunar, 395 and 218 large-artery occlusive, and 568 and 298 cardioembolic strokes in men and women, respectively. After adjustment for baseline age, updated smoking, alcohol consumption, leisure-time physical activity, and histories of hypertension, dyslipidemia, and diabetes mellitus, cumulative average BMI was positively linearly associated with lacunar (trend P = 0.007), large-artery occlusive (trend P = 0.002), and cardioembolic (trend P < 0.001) strokes in men, and with lacunar (trend P < 0.001) and large-artery occlusive (trend P = 0.003) strokes in women. There were approximately two-fold excess risk of cardioembolic stroke in both sexes and of lacunar and large-artery occlusive strokes in women for cumulative average BMI ≥30 kg=m2 compared to BMI 23-<25 kg=m2. Conclusion: Cumulative average BMI showed a positive linear effect on sub-distribution hazards of lacunar, large-artery occlusive, and cardioembolic strokes in both sexes, except for cardioembolic stroke in women.

DOI： 10.2188/jea.JE20170298

労働災害における休業見込期間と実休業日数の差異労働者死傷病報告と実休業日数との乖離査読有り

加藤善士, 太田充彦, 八谷寛

労働安全衛生研究 12 巻 ( 3 ) 頁： 173 - 179 2019年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：(独)労働者健康安全機構労働安全衛生総合研究所

労働基準監督署では,労働災害の重篤度を休業見込期間により判断し,労働災害防止施策を展開している.しかし,労働災害の休業が当初の休業見込期間を超えて長期に及ぶことがある.的確な労働災害防止施策を展開するためには,休業期間を早期に正確に把握することが重要となる.そこで某労働基準監督署管内の過去3年間に発生した労働災害1,672件(男性1,204名,女性468名)について,事業場から報告される労働者死傷病報告と労働者災害補償内容を対比し,休業見込期間と実際の実休業日数の乖離状況を調べ,業種,事業場規模,性別,年齢,業務経験期間,平均賃金との関連を検討した.休業見込期間を超えて実際に休業した者の割合は男性で71.2%,女性で63.9%であった.休業見込期間(中央値:男性30日,女性28日)と実休業日数(中央値:男性50日,女性39日)は男性の方が長かった.休業見込期間を超えて休業する者の割合は,男性において事業場業種,事業場規模,年齢で有意な差が認められた.また,実休業日数/休業見込期間比の中央値は男性1.38,女性1.20と男女間で有意な差があった.労働災害の重篤度を休業見込期間で判断することは,重篤度を過小評価する可能性が高く,実休業日数が休業見込期間を超える割合には,男女で差があった.(著者抄録)

DOI： 10.2486/josh.JOSH-2019-0009-CHO

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