研究者詳細 - 佐藤　ちひろ

論文 - 佐藤　ちひろ

分割表示 376 件中 261 - 280 件目／全件表示 >>

Complex formation of 70-kDa heat shock protein with acidic glycolipids and phospholipids. 査読有り

Harada Y, Sato C, Kitajima K.

Biochem Biophys Res Commun. 353 巻頁： 655-660 2007年

The rainbow trout CMP-sialic acid synthetase utilises a nuclear localization signal different from that identified in the mouse enzyme. 査読有り

Tiralongo J, Fujita A, Sato C, Kitajima K, Lehmann F, Oschlies M, Gerardy-Schahn R, Munster-Kuhnel AK.

Glycobiology 17 巻頁： 945-954 2007年

Identification of an inflammation-inducible serum protein recognized by anti-disialic acid antibodies as carbonic anhydrase II. 査読有り

Yasukawa, Z., Sato, C., and Kitajima, K.

J Biochem. 141 巻頁： 429-441 2007年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Acute phase proteins are an important marker of inflammation and sometimes have a role in the general defense response towards tissue injury. In the present study, we identified a 32 kDa protein that was immunoreactive with monoclonal antibody 2-4B (mAb.2-4B), which is specific to di/oligoNeu5Gc structures, and that behaved as an acute phase protein following stimulation with either turpentine oil or lipopolysaccharides. The 32 kDa protein was identified as carbonic anhydrase II (CA-II), based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analyses of the purified protein. Mouse and human CA-II was immunoreactive and immunoprecipitated with mAb.2-4B, but contained no sialic acid. In addition to mAb.2-4B, the mAb. S2-566 an antibody specific for diNeu5Ac-containing glycans, recognized the CA-II, whereas an anti-oligo/polysialic acid antibody did not. These results indicate that a part of the CA-II protein structure mimics the disialic acid structure recognized by the monoclonal antibodies. This is the first report that CA-II circulates in the serum following inflammation.

シアル酸の構造多様性とその生物学的意義. 招待有り

北島　健、郷　慎司、藤田　明子、佐藤ちひろ

細胞工学 26 巻頁： 629-634 2007年

Membrane microdomain formation is crucial in epiboly during gastrulation of medaka. 査読有り

Adachi, T., Sato, C., and Kitajima, K.

Biochem. Biophys. Res. Commun. 355 巻頁： 174-180 2007年

Development of sensitive chemical and immunochemical methods for detecting sulfated sialic acids and their application to glycoconjugates from sea urchin sperm and eggs 査読有り

Yamakawa, N., Sato C., Miyata, S., Maehashi, E., Toriyama, T., Sato, N., Furuhata, K., and Kitajima. K.

Biochimie 89 巻頁： 1396-1408 2007年

Glycobiology of polysialic acids on sea urchin gametes. 招待有り査読有り

Miyata, S., Sato, C., and Kitajima, K.

Trends Glycosci. Glycotech. 19 巻頁： 83-95 2007年

Hypoxia-enhanced expression of free deaminoneuraminic acid in human cancer cells. 査読有り

Go, S., Sato, C., Yin, J., Kannagi, R., and Kitajima, K.

Biochem. Biophys. Res. Commun. 357 巻頁： 537-542. 2007年

Identification of the nuclear export signals that regulate the intracellular localization of the mouse CMP-sialic acid synthetase. 査読有り

Fujita, A, Sato C, and Kitajima, K.

Biochem. Biophys. Res. Commun. 355 巻頁： 174-180 2007年

The rainbow trout CMP-sialic acid synthetase utilises a nuclear localization signal different from that identified in the mouse enzyme. 査読有り

Tiralongo J, Fujita A, Sato C, Kitajima K, Lehmann F, Oschlies M, Gerardy-Schahn R, Munster-Kuhnel AK

Glycobiology 17 巻頁： 945-954 2007年

Development of sensitive chemical and immunochemical methods for detecting sulfated sialic acids and their application to glycoconjugates from sea urchin sperm and eggs 査読有り

Yamakawa, N, Sato C, Miyata, S, Maehashi, E, Toriyama, T, Sato, N, Furuhata, K, Kitajima. K

Biochimie 89 巻頁： 1396-1408 2007年

Complex formation of 70-kDa heat shock protein with acidic glycolipids and phospholipids. 査読有り

Harada Y, Sato C, Kitajima K

Biochem Biophys Res Commun. 353 巻頁： 655-660 2007年

シアル酸の構造多様性とその生物学的意義. 招待有り

北島健, 郷慎司, 藤田明子, 佐藤ちひろ

細胞工学 26 巻頁： 629-634 2007年

Glycobiology of polysialic acids on sea urchin gametes. 招待有り査読有り

Miyata, S, Sato, C, Kitajima, K

Trends Glycosci. Glycotech. 19 巻頁： 83-95 2007年

Membrane microdomain formation is crucial in epiboly during gastrulation of medaka. 査読有り

Adachi, T, Sato, C, Kitajima, K

Biochem. Biophys. Res. Commun. 355 巻頁： 174-180 2007年

Identification of the nuclear export signals that regulate the intracellular localization of the mouse CMP-sialic acid synthetase. 査読有り

Fujita, A, Sato C, Kitajima, K

Biochem. Biophys. Res. Commun. 355 巻頁： 174-180 2007年

Hypoxia-enhanced expression of free deaminoneuraminic acid in human cancer cells. 査読有り

Go, S, Sato, C, Yin, J, Kannagi, R, Kitajima, K

Biochem. Biophys. Res. Commun. 357 巻頁： 537-542. 2007年

AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss.

Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, Malinow R

Neuron 52 巻 ( 5 ) 頁： 831-43 2006年12月

Expression and functional importance of the carbohydrate antigen 3D11 in early embryo of medaka, Oryzias latipes

Kitajima Ken, Hara Hiroaki, Adachi Tomoko, Sato Chihiro

ZOOLOGICAL SCIENCE 23 巻 ( 12 ) 頁： 1175-1175 2006年12月

Flagellasialin: a novel sulfated alpha2,9-linked polysialic acid glycoprotein of sea urchin sperm flagella. 査読有り

Miyata S, Sato C, Kumita H, Toriyama M, Vacquier VD, Kitajima K

Glycobiology 16 巻 ( 12 ) 頁： 1229 - 41 2006年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Glycobiology

A novel α2,9-linked polysialic acid (polySia)-containing glycoprotein of sea urchin sperm flagella was identified and named "flagellasialin." Flagellasialin from Hemicentrotus pulcherrimus shows a diverse relative molecular mass on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of 40-80 kDa. Flagellasialin is a 96-amino acid, threonine-rich, heavily O-glycosylated (80-90% by weight) glycoprotein with a single transmembrane segment at its C-terminus and no apparent cytosolic domain. Of 12 extracellular Thr residues, eight are O-glycosylated and three are nonglycosylated. Flagellasialin is highly expressed in the testis but cannot be detected in the ovary. The amino acid sequences of flagellasialin from three sea urchin species (H. pulcherrimus, Strongylocentrotus purpuratus, and Strongylocentrotus franciscanus) are identical, but some species differences exist in the three core glycan structures to which the sulfated α2,9-linked polyNeu5Ac chain is linked. Finally, the treatment of sperm with a specific antibody against the α2,9-linked polyNeu5Ac structure results in the elevation of intracellular Ca2+ and inhibition of sperm motility and fertilization, implicating flagellasialin as a regulator of these critical processes. © 2006 Oxford University Press.

DOI： 10.1093/glycob/cwl036

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論文 - 佐藤　ちひろ