研究者詳細 - 佐藤　ちひろ

論文 - 佐藤　ちひろ

分割表示 376 件中 221 - 240 件目／全件表示 >>

Sialome analysis of the cephalochordate Branchiostoma belcheri, a key organism for vertebrate evolution. 査読有り

Guérardel Y, Chang LY, Fujita A, Coddeville B, Maes E, Sato C, Harduin-Lepers A, Kubokawa K, Kitajima K

Glycobiolgy 頁： in press 2012年

Co-expression of two distinct polysialic acids, α2,8- and α2,9-linked polymers of N-acetylneuraminic acid, in distinct glycoproteins and glycolipids in sea urchin sperm. 査読有り

21 巻頁： 1596-1605 2011年12月

New function of polysialic acid and its involvement in neural activities

Sato C.

Seikagaku 83 巻 ( 3 ) 頁： 189-196 2011年12月

Co-expression of two distinct polysialic acids, α2,8- and α2,9-linked polymers of N-acetylneuraminic acid, in distinct glycoproteins and glycolipids in sea urchin sperm. 査読有り

Miyata S, Yamakawa N, Toriyama M, Sato C, Kitajima K

Glycobiology 21 巻頁： 1596-1605 2011年12月

The Roles of Carbohydrate Binding in Cell Adhesion and Inflammation 査読有り

Kitajima K., Sato C.

Carbohydrate Recognition: Biological Problems, Methods, and Applications 頁： 33 - 63 2011年7月

ポリシアル酸の新機能と神経形成維持機構

佐藤ちひろ, 北島健

生化學 83 巻 ( 3 ) 頁： 189-196 2011年3月

ポリシアル酸の新機能と神経形成維持機構査読有り

佐藤ちひろ, 北島　健

生化学 83 巻頁： 189-196 2011年3月

[New function of polysialic acid and its involvement in neural activities].

Sato C, Kitajima K

Seikagaku. The Journal of Japanese Biochemical Society 83 巻 ( 3 ) 頁： 189-96 2011年3月

New functions of polysialic acid and its relationship to schizophrenia 査読有り

Sato C and Kitajima K

23 巻頁： 221-238 2011年

Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in schizophrenia 査読有り

Isomura, R., Kitajima, K., and Sato, C.

J. Biol. Chem. 286 巻頁： 21535-21545 2011年

Human KDN (deaminated neuraminic acid) and its elevated expression in cancer cells: mechanism and significance. 査読有り

Inoue S, Kitajima K, Sato C, Go S

Advances in experimental medicine and biology 705 巻頁： 669 - 78 2011年

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）出版者・発行元：Advances in Experimental Medicine and Biology

Sialic acids are a family of nine-carbon carboxylated sugars having a nonulosonate skeletal structure (Fig. 35.1). This structure is uniquely different from that of other sugar units of animal glycans. The most popular sialic acid is N-acetylneuraminic acid (Neu5Ac), which is universally found on cell surface glycocalyx and in secreted glycoproteins of vertebrates and some invertebrates. Sialic acids have low acid-base dissociation constants and give a negative charge on the cell surface under a wide range of physiological pH. In nature, more than 50 kinds of sialic acids are known. Nearly all of them are derived from Neu5Ac by a substitution on the hydroxyl groups (e.g., O-acetyl-Neu5Ac) and/or a hydroxylation of the N-acetyl group (e.g., N-glycolylneuraminic acid, Neu5Gc). Each modified sialic acid has properties different from those of Neu5Ac and is believed to contribute to specific physiological functions. In animal cells, sialic acids are most frequently the terminal sugars of cell surface glycolipids and glycoproteins, and any change that occurs on sialic acids can considerably influence the biological properties of a cell. © 2011 Springer Science+Business Media, LLC.

DOI： 10.1007/978-1-4419-7877-6_35

Web of Science

Scopus

PubMed

Mechanism regulating Ca2+-dependent mechanosensory behaviour in sea urchin spermatozoa. 査読有り

Kambara Y, Shiba K, Yoshida M, Sato C, Kitajima K, Shingyoji C

Cell structure and function 36 巻 ( 1 ) 頁： 69 - 82 2011年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Cell Structure and Function

Flagellar movement of the sea urchin sperm is regulated by intracellular Ca2+. Flagellasialin, a polysialic acid-containing glycoprotein, as well as other membrane proteins seems responsible for the Ca2+ control. To elucidate the mechanism of Ca2+ dynamics underlying flagellar movement, we analysed the sperm's mechanosensory behavioural responses by using microtechniques. In sea water containing 10 mM Ca2+, the sperm swim in circular paths. When a mechanical stimulus was applied to the sperm head with a glass microstylus, the sperm showed a series of flagellar responses, consisting of a stoppage of beating (quiescence) and a recovery of swimming in a straight path, followed by swimming in a circular path again; as the result the sperm avoided the obstacle. Ca2+-imaging with Fluo-4 showed that the intracellular Ca2+ was high in the quiescence and gradually decreased after that. The effects of blockers and antibodies against candidate components revealed that the Ca2+ influx was induced by Ca2+ channels and the Ca2+ efflux was induced by a flagellasialin-related Ca2+- efflux system, plasma membrane Ca2+-ATPases and the K+-dependent Na+/Ca2+ exchanger. The results show that the Ca2+-dependent mechanosensory behaviour of the sea urchin sperm is regulated by organized functioning of the membrane environment including the plasma membrane proteins and flagellasialin. © 2011 by Japan Society for Cell Biology.

DOI： 10.1247/csf.10020

Mechanism Regulating Ca2+-dependent Mechanosensory Behaviour in Sea Urchin Spermatozoa

Kambara Yuka, Shiba Kogiku, Yoshida Manabu, Sato Chihiro, Kitajima Ken, Shingyoji Chikako

CELL STRUCTURE AND FUNCTION 36 巻 ( 1 ) 頁： 69-82 2011年

Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in schizophrenia 査読有り

Isomura, R, Kitajima, K, Sato, C

J. Biol. Chem. 286 巻頁： 21535-21545 2011年

New functions of polysialic acid and its relationship to schizophrenia 査読有り

Sato C, Kitajima K

TIGG 23 巻頁： 221-238 2011年

Developmental stage-dependent expression of an alpha2,8-trisialic acid unit on glycoproteins in mouse brain. 査読有り

Inoko E, Nishiura Y, Tanaka H, Takahashi T, Furukawa K, Kitajima K, Sato C

Glycobiology 20 巻 ( 7 ) 頁： 916 - 28 2010年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Glycobiology

The monoclonal antibody mAb.A2B5 is a marker for the detection of oligodendrocyte progenitor cells that differentiate into type-2 astrocytes and oligodendrocytes. It is also a useful antibody for separating these cells from other lineage populations. The epitope of this antibody is considered to be the gangliosides GT3 and GQ1c. In this study, we sought to define more precisely the structure of the epitope. Accordingly, we chemically synthesized defined oligosialic acid structures linked to phosphatidylethanolamine and bovine serum albumin and used these to determine the antigenic specificity. mAb.A2B5 recognized the Neu5Acα2→8-Neu5Acα2→8Neu5Acα → structure on both glycolipids and glycoproteins. We then examined whether the mAb. A2B5 epitope exists on glycoproteins in developing mouse brains. Western blot analyses revealed the expression of four glycoproteins reactive with the mAb.A2B5, and their expression was dependent on the stage of neural development. All the immunoreactivity in these glycoproteins with mAb.A2B5 disappeared after sialidase treatment and were resistant to chloroform/methanol extraction. These epitopes were also detected in brain homogenates from both GD3 synthetase-null and GD3/GD2 synthetase double null mice. These findings show that the α 2,8- trisialic acid (triSia) unit recognized by mAb.A2B5 resides not only on gangliosides but also on glycoproteins in developing mouse brain. We postulate that the triSia structure on glycoproteins may be involved in oligodendrocyte differentiation, similar to the case with the α 2,8-triSia structure on gangliosides. Real time polymerase chain reaction analysis of the developmental expression of all known ST8Sia genes, which are responsible for the biosynthesis of α 2,8- linked Sia residues, showed that ST8Sia III gene expression correlated with expression of the triSia epitope. We suggest that ST8Sia III is the principal sialyltransferase responsible for synthesis of the α 2,8-triSia units on glycoproteins. © The Author 2010. Published by Oxford University Press. All rights reserved.

DOI： 10.1093/glycob/cwq049

Web of Science

Scopus

PubMed

糖鎖と統合失調症招待有り

佐藤ちひろ

生体の科学 61 巻頁： 160-166 2010年

IgG2 dominancy and carbohydrate recognition specificity of C3H/He mouse antibodies directed to cross-reactive carbohydrate determinants (CCDs) bearing beta-(1,2)-xylose and alpha-(1,3)-fucose. 査読有り

Hino S, Umeda F, Inumaru S, Aoki N, Sato, C., Okajima T, Nadano D, Matsuda T.

Immunol Lett 133 巻頁： 28-34 2010年

Survival signals of hepatic stellate cells in liver regeneration are regulated by glycosylation changes in rat vitronectin, especially decreased sialylation. 査読有り

Sano K, Miyamoto Y, Kawasaki N, Hashii N, Itoh S, Murase M, Date K, Yokoyama M, Sato, C., Kitajima K, Ogawa H.

J Biol Chem 285 巻頁： 17301-17309 2010年

Extensive enrichment of N-glycolylneuraminic acid in extracellular sialoglycoproteins abundantly synthesized and secreted by human cancer cells. 査読有り

Inoue, S., Sato, C. and Kitajima, K

Glycobiology 20 巻頁： 752-762 2010年

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