Faculty Profiles - ISHIKAWA, Kenji

Papers - ISHIKAWA, Kenji

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Low-temperature growth at 225 °C and characterization of carbon nanowalls synthesized by radical injection plasma-enhanced chemical vapor deposition Reviewed Open Access

Ngo Quang Minh, Ngo Van Nong, Osamu Oda, Kenji Ishikawa, and Masaru Hori

Vacuum Vol. 224 page： 113180 2024.6

Epitaxial growth of high-quality GaN with a high growth rate at low temperatures by radical-enhanced metalorganic chemical vapor deposition Reviewed Open Access

Arun Kumar Dhasiyan, Frank Wilson Amalraj, Swathy Jayaprasad, Naohiro Shimizu, Osamu Oda, Kenji Ishikawa, and Masaru Hori

Scientific Reports Vol. 14 ( 1 ) page： 10861 2024.5

In situ atom-resolved observation of Si (111) 7×7 surface with F radical and Ar ion irradiation simulated atomic layer etching Reviewed Open Access

Takayoshi Tsutsumi, Atsuki Asano, Hiroki Kondo, Kenji Ishikawa, Makoto Sekine, and Masaru Hori

Journal of the Vacuum Science and Technologies A Vol. 42 ( 3 ) page： 032603 2024.5

Nitrogen admixture effects on growth characteristics and properties of carbon nanowalls Reviewed Open Access

Peter Raj Dennis Christy, Ngo Van Nong, Nikolay Britun, Ngo Quang Minh, Thi-Thuy-Nga Nguyen, Hiroki Kondo, Osamu Oda, Kenji Ishikawa and Masaru Hori

Thin Solid Films Vol. 795 page： 140322 2024.4

Dissociative properties of C4F6 obtained using computational chemistry Reviewed Open Access

Toshio Hayashi, Kenji Ishikawa, Makoto Sekine, and Masaru Hori

Japanese Journal of Applied Physics Vol. 63 ( 4 ) page： 04SP26 2024.4

Inhibition of glutamine metabolism increases sensitivity to plasma-activated medium-induced cytotoxicity Reviewed

Shu Tanaka, Sae Hayashi, Tomohiro Otsuka, Tetsuro Kamiya, Kenji Ishikawa, and Hirokazu Hara

Free Radical Research Vol. 58 ( 3 ) page： 170 - 179 2024.3

Plasma-driven sciences: Exploring complex interactions at plasma-boundaries Reviewed Open Access

Kenji Ishikawa, Kazunori Koga, and Noriyasu Ohno

Plasma Vol. 7 ( 1 ) page： 160 - 177 2024.2

High-speed Synthesis and Functionalization of Nanographene by In-liquid Plasma Reviewed Open Access

KONDO Hiroki, TSUTSUMI Takayoshi, ISHIKAWA Kenji, HORI Masaru, HIRAMATSU Mineo

Vacuum and Surface Science Vol. 67 ( 2 ) page： 77 - 82 2024.2

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Vacuum and Surface Science

A novel synthesis method of nanographene materials by using in-liquid plasma has been developed. By this method, the high synthesis rate of nanographene up to 1 mg/min. can be realized. There is a trade-off relationship between synthesis rate and crystallographic domain size with respect to the number of carbon atoms in the raw alcohol molecules. For example, when using 1-butanol (C4H9OH), the synthesis rate is approximately twice as high as when using ethanol (C2H5OH), but the domain size, which indicates crystallographic quality, is about half smaller. On the other hand, when using hexane (C6H14) or benzene (C6H6), the synthesis rate is approximately 17 times and 1.7 times faster than when using hexanol (C6H13OH), respectively, but their domain size is much smaller compared with that by ethanol. This indicates an effect of OH radicals on the domain size improvement. By adding iron (II) phthalocyanine, etc. to the alcohol raw material, nitrogen-doped nanographene materials were successfully synthesized and confirmed their catalytic activity. The mechanism of expression of catalytic activity was also clarified.

DOI： 10.1380/vss.67.77

Open Access

CiNii Research

Elaborate Cooperation of Poly(rC)-binding Proteins 1/2 and Glutathione in Ferroptosis Induced by Plasma-activated Ringer' s Lactate Reviewed Open Access

Li Jiang, Hao Zheng, Moe Ishida, Qinying Lyu, Shinya Akatsuka, Yashiro Motooka, Kotaro Sato, Yoshitaka Sekido, Kae Nakamura, Hiromasa Tanaka, Kenji Ishikawa, Hiroaki Kajiyama, Masaaki Mizuno, Masaru Hori, and Shinya Toyokuni

Free Radical Biology and Medicine Vol. 214 page： 28 - 41 2024.2

Surface sulfurization of amorphous carbon films in the chemistry of oxygen plasma added with SO2 or OCS for high-aspect-ratio etching Reviewed Open Access

Kenji Ishikawa, Thi-Thuy-Nga Nguyen, Yuta Aoki, Hiroyasu Sato, Junichi Kawakami, Shuji Tsuno, Shin-Nan Hsiao, and Masaru Hori

Applied Surface Science Vol. 645 page： 158876 2024.2

Oxygen radical irradiation transforms an organic fertilizer l-tryptophan into an environment and human-friendly bactericide Reviewed Open Access

Naoyuki Iwata, Kenji Ishikawa, Yasuhiro Nishikawa, Hiroyuki Kato, Motoyuki Shimizu, Masashi Kato, Hiromasa Tanaka, Masafumi Ito, and Masaru Hori

Environmental Technology and Innovation Vol. 33 page： 103496 2024.2

High linear energy transfer (LET) nature of alanine radical yield by soft X-ray irradiations studied by electron spin resonance (ESR) applications Reviewed

Seiko Nakagawa, Akinari Yokoya, Maki Ohara, Noriko Usami, Mizue Asada, Motoyasu Fujiwara, Toshikazu Nakamura, and Kenji Ishikawa

Radiation Physics and Chemistry Vol. 214 page： 111304 2024.1

Cold Atmospheric Pressure Plasma-Activated Liquids for Cancer Treatment Reviewed

Miron, C; Hiromasa, T; Britun, N; Hashizume, H; Ishikawa, K; Du, LY; Yamakawa, T; Kurebayashi, Y; Kondo, T; Kondo, H; Kajiyama, H; Toyokuni, S; Mizuno, M; Hori, M

ADVANCES IN DIGITAL HEALTH AND MEDICAL BIOENGINEERING, VOL 3, EHB-2023 Vol. 111 page： 150 - 162 2024

Language：English Publishing type：Research paper (scientific journal) Publisher：IFMBE Proceedings

Low-temperature plasma (LTP) is a promising tool that can assist in cancer treatment. Plasma-treated liquids have shown a selective cytotoxic effect on cancer cells attributed to reactive species formed in discharge, but this mechanism is not completely understood. In this study, the chemical compounds formed by plasma irradiation of Ringer’s lactate solutions and their effects on non-tumorigenic breast epithelial cells (MCF-10A) and breast cancer cells (MCF-7) were investigated. Among these compounds, glyceric acid increased the cell viability by more than two-fold compared to the control samples for MCF-10A and MCF-7 cells, whereas the tricarballylic acid had a pronounced cytotoxic effect on the cells when incubated with solutions of 0.6 mM to 50 mM concentrations. A good selectivity in killing the cancer cells was observed when the chemical compounds identified in plasma-treated liquids (such as ethyl acetate, glyceric acid, and tricarballylic acid) were used in a mixture solution of a certain concentration. The results show that the LTP-generated chemical compounds have both, stimulatory and inhibitory effects on cell viability, and the best selectivity is achieved only when these compounds are combined in a certain amount and have a synergistic effect, completely killing only the cancer cells.

DOI： 10.1007/978-3-031-62523-7_17

Web of Science

Scopus

Bias-supply timing tailored to the aspect ratio dependence of silicon trench etching in Ar plasma with alternately injected C4F8 and SF6 Reviewed Open Access

Taito Yoshie, Kenji Ishikawa, Thi-Thuy-Nga Nguyen, Shih-Nan Hsiao, Takayoshi Tsutsumi, Makoto Sekine, and Masaru Hori

Applied Surface Science Vol. 638 page： 157981 2023.11

An approach to reduce surface charging with cryogenic plasma etching using hydrogen-fluoride contained gases Reviewed

Shih-Nan Hsiao, Makoto Sekine, Kenji Ishikawa, Yuki Iijima, Yoshinobu Ohya, and Masaru Hori

Applied Physics Letters Vol. 123 ( 21 ) page： 1 - 4 2023.11

Gas-phase study of the behavior of trimethyl gallium and triethyl gallium by optical emission spectroscopy and quadrupole mass spectroscopy for the growth of GaN by REMOCVD (radical-enhanced metalorganic chemical vapor deposition) Reviewed

Arun Kumar Dhasiyan, Swathy Jayaprasad, Frank Wilson Amalraj, Naohiro Shimizu, Osamu Oda, Kenji Ishikawa, and Masaru Hori

Japanese Journal of Applied Physics Vol. 62 ( SN ) page： SN1019 2023.11

Deposition of carbon-based materials directly on copper foil and nickel foam as 2D-and 3D-networked metal substrates by in-liquid plasma Reviewed Open Access

Ma. Shanlene D.C. Dela Vega, Thi-Thuy-Nga Nguyen, Hiroki Kondo, Takayoshi Tsutsumi, Kenji Ishikawa, and Masaru Hori

Plasma Processes and Polymers Vol. 20 ( 11 ) page： 1 - 5 2023.11

The Possibility of Cancer Therapy with a Combination of Low-temperature Plasma and Hyperthermia Invited Reviewed

KONDO TAKASHI, HASHIZUME HIROSHI, TANAKA HIROMASA, ISHIKAWA KENJI, SAITOH JUN-ICHI, HORI MASARU

Thermal Medicine Vol. 39 ( 3 ) page： 21 - 30 2023.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society for Thermal Medicine

Low temperature plasma (LTP) has been proposed as a novel therapeutic method for its anti-cancer potential. However, its biological effects in combination with other physical modalities remain to be elusive. Therefore, this study was aimed to determine the effects of low temperature helium plasma (He-LTP) in combination with mild hyperthermia (HT, 42℃ for 20 min). Human lymphoma U937 cells were exposed to HT, immediately after He-LTP treatment. He-LTP in combination with HT showed enhanced cell death, which was accompanied by increased intracellular reactive oxygen species (ROS) production. These findings suggest that He-LTP can enhance the apoptotic effects of mild HT due to the increased in intracellular ROS generation as He-LTP has been known to caused marked induction of ROS in the aqueous medium. These findings would be helpful when establishing a therapeutic strategy for LTP in combination with mild HT. Here, the biological effects of LTP, and the combination with hyperthermia and LTP or LTP -activated solutions for cancer therapy have been summarized in this review.

DOI： 10.3191/thermalmed.39.21

CiNii Research

Development of an experimental system for cell viability assays of yeasts using gas-temperature controllable plasma jets Reviewed Open Access

Yoshimura, S; Otsubo, Y; Yamashita, A; Johzuka, K; Tsutsumi, T; Ishikawa, K; Hori, M

Japanese Journal of Applied Physics Vol. 62 ( SL ) 2023.9

Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Journal of Applied Physics

The characteristics of a gas-temperature-controllable atmospheric-pressure helium plasma jet and the development of an experimental system for cell viability assays of yeasts (fission yeast Schizosaccharomyces pombe and budding yeast Saccharomyces cerevisiae) are reported. The physicochemical properties of the plasma plume, which can maintain the temperature of the irradiated object at a temperature suitable for yeast, were not significantly different from those of a typical helium plasma jet. Furthermore, good reproducibility of cell viability was observed when gas temperature, gas flow rate, applied high voltage, and irradiation distance remained fixed, and only irradiation time was used as a parameter. This experimental system allows us to carry out various experiments, such as the search for plasma-resistant mutants that will contribute to the identification of genes involved in resistance to direct plasma irradiation.

DOI： 10.35848/1347-4065/acd4ca

Web of Science

Scopus

Organic decomposition and synthesis reactions in lactated solution exposed to nonequilibrium atmospheric pressure plasma Reviewed

Liu, Y; Ishikawa, K; Tanaka, H; Miron, C; Kondo, T; Nakamura, K; Mizuno, M; Kajiyama, H; Toyokuni, S; Hori, M

PLASMA PROCESSES AND POLYMERS Vol. 20 ( 5 ) 2023.5

Language：English Publishing type：Research paper (scientific journal) Publisher：Plasma Processes and Polymers

Lactate is used in the food and pharmaceutical industries and is a crucial intermediate for synthesis. Plasma-activated lactate (PAL) in Ringer's solution was recently shown to have effective antitumor action. Small molecule aldehydes, ketones, and organic acids were produced from lactate during plasma exposure, and five-membered conjugated lactone isomers of furanone (C5H6O2) were detected formed by interactions of lactate or its fragments with •OH, organic radicals, and H2O2. 2,3-Dimethyl-tartaric acid may be the effective component in PAL for the selective killing of cancer but not normal cells and possible pathways for its synthesis are provided. Aqueous reaction mechanisms are explained, including dehydration, esterification, hydrolysis, and dimerization. This study will help develop novel cancer therapies and further plasma organic chemistry.

DOI： 10.1002/ppap.202200193

Web of Science

Scopus

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Papers - ISHIKAWA, Kenji