Faculty Profiles - MIZUNO, Masashi

Papers - MIZUNO, Masashi

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Transforming growth factor-beta induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction International journal

Suzuki Yasuhiro, Ito Yasuhiko, Mizuno Masashi, Kinashi Hiroshi, Sawai Akiho, Noda Yukihiro, Mizuno Tomohiro, Shimizu Hideaki, Fujita Yoshiro, Matsui Katsuyuki, Maruyama Shoichi, Imai Enyu, Matsuo Seiichi, Takei Yoshifumi

KIDNEY INTERNATIONAL Vol. 81 ( 9 ) page： 865 - 879 2012.5

Atrial natriuretic peptide ameliorates peritoneal fibrosis in rat peritonitis model Reviewed International journal

Hiroshi Kato, Tomohiro Mizuno, Masashi Mizuno, Akiho Sawai, Yasuhiro Suzuki, Hiroshi Kinashi, Fumiko Nagura, Shoichi Maruyama, Yukihiro Noda, Kiyofumi Yamada, Seiichi Matsuo, Yasuhiko Ito

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 27 ( 2 ) page： 526 - 536 2012.2

Language：English Publishing type：Research paper (scientific journal) Publisher：OXFORD UNIV PRESS

Atrial natriuretic peptide (ANP) was recently reported to ameliorate fibrosis in the heart and experimental renal diseases and vascular thickening after balloon injury. Peritoneal fibrosis is an important complication of long-term peritoneal dialysis, and peritonitis is a factor in its onset. In the present study, we investigated the effects of ANP in a rat peritonitis-induced peritoneal fibrosis model.
As pretreatment, an osmotic pump containing vehicle (saline) or ANP (0.15 or 0.3 mu g/min) was inserted through the carotid vein in male Sprague-Dawley rats. ANP or saline was continuously infused using the osmotic pump. Three days after administration of ANP or saline, rats underwent peritoneal scraping in a blind manner and were sacrificed on Day 14. The effects of ANP were evaluated based on peritoneal thickness, immunohistochemistry and real-time polymerase chain reaction. In each experiment, we evaluated messenger RNA (mRNA) expression of the ANP receptor natriuretic peptide receptor A (NPR-A) in the peritoneum after scraping. The effects of ANP were also studied in cultured peritoneal fibroblasts and mesothelial cells.
We observed a significant increase in NPR-A mRNA in the peritoneum. Peritoneal thickness increased with time and peaked on Day 14, but ANP significantly reduced peritoneal thickness. Parameters such as number of macrophages and CD-31-positive vessels and expression of type III collagen/transforming growth factor-beta/plasminogen activator inhibitor-1 (PAI-1)/connective tissue growth factor (CTGF) were significantly suppressed by ANP. In cultured peritoneal fibroblasts and mesothelial cells, ANP suppressed angiotensin II-induced upregulation of CTGF and PAI-1.
Our results suggest that ANP is useful in preventing inflammation-induced peritoneal fibrosis.

DOI： 10.1093/ndt/gfr302

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Renal impairment after laparoscopic radical nephrectomy affects hypoglycaemic therapy Reviewed International journal

Mizuno T., Ito K., Miyagawa Y., Kimura K., Suzuki Y., Mizuno M., Ito Y., Funahashi Y., Hattori R., Gotoh M., Noda Y., Yamada K.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS Vol. 37 ( 1 ) page： 49 - 52 2012.2

Aliskiren-Induced Chyloperitoneum in a Patient on Peritoneal Dialysis Reviewed International journal

Y. Saka, H. Tachi, H. Sakurai, M. Tawada, A. Sawai, Y. Shimamura, M. Mizuno, S. Maruyama, S. Matsuo, Y. Ito

PERITONEAL DIALYSIS INTERNATIONAL Vol. 32 ( 1 ) page： 111 - U123 2012.1

Aliskiren-induced chyloperotoneum in a patient on peritoneal dialysis. et al. A case report. Reviewed

Saka Y, Tachi H, Sakurai H, Tawada M, Sawai A, Shimamura Y, Mizuno M, Maruyama S, Matsuo S, Ito Y.

Perit Dial Int Vol. 32 page： 111-113 2012

Guideline for hereditary angioedema (HAE) 2010 by the Japanese association for complement research. Invited Reviewed

Horiuchi T., Ohi H., Ohsawa I., Fujita T., Matsushita M., Okada N., Seya T., Yamamoto T., Endo Y., Hatanaka M., Wakamiya N., Mizuno M., Nakao M., Okada H., Tsukamoto H., Matsumoto M., Inoue N., Nonaka M., Kinoshita T.

Allergol Int Vol. 61 ( 4 ) page： 559-562 2012

Short-term administration of diclofenac sodium affects renal function after laparoscopic radical nephrectomu in elderly patients. Reviewed

Mizuno T., Ito K., Miyagawa Y., Ishikawa K., Suzuki Y., Mizuno M., Ito Y., Funabashi Y., Hattori R., Gotoh M., Yamada K., Noda Y.

Jpn J Clin Oncol Vol. 42 ( 11 ) page： 1073-1078 2012

Exploiting the nephrotoxic effects of venom from the sea anemone, Phyllodiscus semoni, to create a hemolytic uremic syndrome model in the rat. Invited Reviewed

Mizuno M., Ito Y, Morgan BP.

Marine Drugs Vol. 10 page： 1582-1604 2012

Combined values of serum albumin, C-reactive protein and body mass index at dialysis initiation accurately predicts log-term mortality. Reviewed

Takahashi R., Ito Y., Takahashi H., Ishii H., Kasuga H., Mizuno M., Suzuki Y., Yuzawa Y., Maruyama S., Murohara T., Imai E., Matsuo S.

Am J Nephrol Vol. 36 page： 136-143 2012

A rare case of acute kidney injury associated with autoimmune hemolytic anemia and thrombocytopenia after long-term usage of oxaliplatin. Reviewed

Ito I., Ito Y., Mizuno M., Suzuki Y., Yasuda K., Ozaki T., Kosugi T., Yasuda Y., Sato Y., Tsuboi N., Maruyama S., Imai E., Matsuo S.

Clin Exp Nephrol Vol. 16 page： 490-494 2012

Membrane complement regulators protect against fibrin exudation in a severe peritoneal inflammation model in rats. Reviewed

Mizuno M., Ito Y., Mizuno T., Suzuki Y., Harris CL., Okada N, Matsuo S, Morgan BP.

Am J Physil Renal Physiol Vol. 302 page： F1245-F1251 2012

Transforming growth factor-β induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction. Reviewed

Suzuki Y., Ito Y., Mizuno M., Kinashi H., Sawai A., Noda Y., Mizuno T., Shimizu H., Fujita Y., Matsui K., Maruyama S., Imai E., Matsuo S., Takei Y.

Kidney Int. Vol. 81 page： 865-879 2012

Renal impairment after laparoscopic radical nephrectomy affects hypoglycemic therapy. Reviewed

Mizuno T., Ito K., Miyagawa Y., Kimura K., Suzuki K., Mizuno M., Ito Y., Funabashi Y., Hattori R., Gotoh M., Noda Y., Yamada K.

J. Clin Pharm Therapy Vol. 37 page： 49-52 2012

Atrial natriuretic peptide ameliorates peritoneal fibrosis in a rat peritonitis model. Reviewed

Kato H., Mizuno T., Mizuno M., Sawai A., Suzuki Y., Kinashi H., Nagura F., Maruyama S., Noda Y., Yamada K., Matsuo S., Ito Y.

Nephrol. Dial. Transplant. Vol. 27 page： 526-536 2012

各論２　腹膜透析ガイドライン, 3. 腹膜炎管理 ISPDガイドラインを本邦の実地臨床にいかに活用するか？本邦のガイドラインをいかにすべきか？ Invited

伊藤恭彦、水野正司、鈴木康弘、清祐実、平松英樹、松尾清一

臨床透析 Vol. 28 page： 856-864 2012

至摘透析・体液管理, 腹膜透析における小・中・大分子量物質除去と腹膜機能の関連性

5. 平松英樹、伊藤恭彦、水野正司、鈴木康弘、戸田晋、坪井直毅、伊藤功、佐藤和一、丸山彰一、今井圓裕、林裕樹、松尾清一

腎と透析 2012 （腎と透析　別冊） Vol. 73 page： 235-236 2012

IV. 課題と対策（２）腹膜炎 - 名古屋大学関連施設レジストリーからみたPD腹膜炎の問題点. Invited

伊藤恭彦、水野正司、鈴木康弘、他

臨床と透析 Vol. 28 page： 571-577 2012

腹膜組織における補体活性化の観点からみた、現在の透析液の問題

水野正司、伊藤恭彦、鈴木康弘、松尾清一

腎と透析 2012 （腎と透析　別冊） Vol. 73 page： 109-110 2012

遺伝子組換えヒトエリスロポエチンによる赤血球造血刺激因子製剤療法低反応性腹膜透析患者の持続型赤血球層血刺激因子製剤Darbepoetin Alfa投与の効果 Reviewed

平松英樹、林祐樹、水野正司、鈴木康弘、戸田晋、伊藤功、丸山彰一、伊藤恭彦、松尾清一

日本透析医学会会誌 Vol. 45 page： 247-253 2012

Adequate administration of darbepoetin alfa improves renal anemia in Japanese peritoneal dialysis patients for whom the maximum dose of recombinant human erythropoietin did not fully achieve improved anemia International coauthorship

Hiramatsu Hideki, Hayashi Hiroki, Mizuno Masashi, Suzuki Yasuhiro, Toda Susumu, Ito Isao, Maruyama Shoichi, Ito Yasuhiko, Matsuo Seiichi

Nihon Toseki Igakkai Zasshi Vol. 45 ( 3 ) page： 247 - 253 2012

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society for Dialysis Therapy

Although the maximum approved dosage of recombinant human erythropoietin (rHuEPO) is 24,000IU/month in patients on peritoneal dialysis (PD) therapy in Japan, the improvement of renal anemia is not always satisfactorily maintained at a blood hemoglobin (Hb) level>10.0g/dL. Among 46 patients on PD therapy in our hospital, we investigated the effects of darbepoetin alfa (DA) in 8 patients (DA group) with Hb<10.0g/dL after the administration of rHuEPO at 12,000IU/2 weeks, compared with the 38 other patients (non-DA group) with Hb>10.0g/dL after the administration of rHuEPO at a dose<12,000IU/2 weeks. In terms of background data, the residual renal function was lower and serumβ<SUB>2</SUB> microglobulin level was higher in the DA group, compared with the non-DA group. As an inflammatory marker, the serum C-reactive protein level was also higher in the DA group than in the non-DA group. After 18 weeks of DA administration instead of rHuEPO, the mean (±standard deviation) Hb level increased to 11.0±0.8g/dL. The Hb level eventually reached>10.0g/dL in all patients using DA instead of rHuEPO. Of note, serum ferritin levels in all 46 patients were within the normal range, suggesting that low iron storage was not a direct reason for anemia in this study. The present results suggest that renal anemia in patients on PD therapy who remained inadequately managed using the maximum approved dosage of rHuEPO was caused by an inadequate dosage of rHuEPO, and might be controlled to target levels using an adequate dosage of DA.

DOI： 10.4009/jsdt.45.247

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