Faculty Profiles - MIZUNO, Masashi

Papers - MIZUNO, Masashi

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Vascular Endothelial Cell Injury Is an Important Factor in the Development of Encapsulating Peritoneal Sclerosis in Long-Term Peritoneal Dialysis Patients. Reviewed International journal

Tawada M, Ito Y, Hamada C, Honda K, Mizuno M, Suzuki Y, Sakata F, Terabayashi T, Matsukawa Y, Maruyama S, Imai E, Matsuo S, Takei Y

PloS one Vol. 11 ( 4 ) page： e0154644 2016.4

Depression of complement regulatory factors in rat and human renal grafts is associated with the pregress of acute T-cell medicated rejection. Reviewed

Yamanaka K., Kakuta Y., Miyagawa S., Nakazawa S., Kato T., Abe T., Imamura R., Okumi M., Maeda A., Mizuno M., Nonomura N.

PlosOne Vol. 11 ( 2 ) page： e0148881 2016

Rat Models of Acute and/or Chronic Peritoneal Injuries Including Peritoneal Fibrosis and Peritoneal Dialysis Complications

Mizuno Masashi, Ito Yasuhiko

KIDNEY RESEARCH: EXPERIMENTAL PROTOCOLS, 2ND EDITION Vol. 1397 page： 35 - 43 2016

Increase of Antimyeloperoxidase Antineutrophil Cytoplasmic Antibody (ANCA) in Patients with Renal ANCA-associated Vasculitis: Association with Risk to Relapse. Reviewed International journal

Yamaguchi M, Ando M, Kato S, Katsuno T, Kato N, Kosugi T, Sato W, Tsuboi N, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S

The Journal of rheumatology Vol. 42 ( 10 ) page： 1853 - 1860 2015.10

Vascular endothelial growth factor receptor-3 is a novel target to improve net ultrafiltration in methylglyoxal-induced peritoneal injury Reviewed International journal

Takeshi Terabayashi, Yasuhiko Ito, Masashi Mizuno, Yasuhiro Suzuki, Hiroshi Kinashi, Fumiko Sakata, Takako Tomita, Daiki Iguchi, Mitsuhiro Tawada, Ryosuke Nishio, Shoichi Maruyama, Enyu Imai, Seiichi Matsuo, Yoshifumi Takei

LABORATORY INVESTIGATION Vol. 95 ( 9 ) page： 1029 - 1043 2015.9

Language：English Publishing type：Research paper (scientific journal) Publisher：NATURE PUBLISHING GROUP

Appropriate fluid balance is important for good clinical outcomes and survival in patients on peritoneal dialysis. We recently reported that lymphangiogenesis associated with fibrosis developed in the peritoneal cavity via the transforming growth factor-beta 1-vascular endothelial growth factor-C (VEGF-C) pathway. We investigated whether VEGF receptor-3 (VEGFR-3), the receptor for VEGF-C and -D, might be a new target to improve net ultrafiltration by using adenovirus-expressing soluble VEGFR-3 (Adeno-sVEGFR-3) in rodent models of peritoneal injury induced by methylglyoxal (MGO). We demonstrated that lymphangiogenesis developed in these MGO models, especially in the diaphragm, indicating that lymphangiogenesis is a common feature in the peritoneal cavity with inflammation and fibrosis. In MGO models, VEGF-D was significantly increased in the diaphragm; however, VEGF-C was not significantly upregulated. Adeno-sVEGFR-3, which was detected on day 50 after administration via tail vein injections, successfully suppressed lymphangiogenesis in the diaphragm and parietal peritoneum in mouse MGO models without significant effects on fibrosis, inflammation, or neoangiogenesis. Drained volume in the peritoneal equilibration test using a 7.5% icodextrin peritoneal dialysis solution (the 7.5% icodextrin peritoneal equilibration test) was improved by Adeno-sVEGFR-3 on day 22 (P<0.05) and day 50 after reduction of inflammation (P<0.01), indicating that the 7.5% icodextrin peritoneal equilibration test identifies changes in lymphangiogenesis. The solute transport rate was not affected by suppression of lymphangiogenesis. In human peritoneal dialysis patients, the dialysate to plasma ratio of creatinine positively correlated with the dialysate VEGF-D concentration (P<0.001). VEGF-D mRNA was significantly higher in the peritoneal membranes of patients with ultrafiltration failure, indicating that VEGF-D is involved in the development of lymphangiogenesis in peritoneal dialysis patients. These results indicate that VEGFR-3 is a new target to improve net ultrafiltration by suppressing lymphatic absorption and that the 7.5% icodextrin peritoneal equilibration test is useful for estimation of lymphatic absorption.

DOI： 10.1038/labinvest.2015.87

Web of Science

PubMed

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Development of encapsular peritoneal sclerosis (EPS)-like peritonitis in rat and complement activation International journal

Daiki Iguchi, Masashi Mizuno, Emi Shigemoto, Fumiko Sakata, Yasuhiro Suzuki, Alan Okada, Hidechika Okada, Shoichi Maruyama, Seiichi Matsuo, Yasuhiko Ito

MOLECULAR IMMUNOLOGY Vol. 67 ( 1 ) page： 145 - 146 2015.9

Calcified Amorphous Tumor in the Left Atrium in a Patient on Long-term Peritoneal Dialysis Reviewed International journal

Tanaka Akihito, Mizuno Masashi, Suzuki Yasuhiro, Oshima Hideki, Sakata Fumiko, Ishikawa Hideaki, Tsukushi Saori, Ito Yasuhiko

Internal Medicine Vol. 54 ( 5 ) page： 481 - 485 2015

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine

A 66-year-old woman with an 11-year history of peritoneal dialysis (PD) for diabetic nephropathy and renal failure exhibited a movable tumor in the left atrium on echocardiography. Tumor resection was performed due to the difficulty in diagnosing the tumor and the future risk of heart failure and embolization. Light microscopy showed a calcified amorphous tumor (CAT), a rare intracardiac mass characterized by the presence of a pedicle and diffuse calcification. An increased calcium-phosphate product level was suspected as an etiology, although degeneration, inflammation and/or mineral balance disorders may also induce the development of CAT. We herein report the first known case of CAT in a PD patient.

DOI： 10.2169/internalmedicine.54.2967

The efficacy of tolvaptan as a diuretic for chronic kidney disease patients. Reviewed

Tanaka A., Katsuno T., Ozaki T., Sakata F., Kato N., Suzuki Y., Kosugi T., Kato S., Tsuboi N., Sato W., Yasuda Y., Mizuno M., Ito Y., Matsuo S., Maruyama S.

Vol. 70 page： 217-223 2015

Smoking is a risk factor for the relapse of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis.

Yamaguchi M., Ando M., Kato S., Katsuno T., Kato N., Kosugi T., Sato W., Tsuboi N., Yasuda Y., Mizuno M., Ito Y., Matsuo S., Maruyama S

J Rheumatology page： in press 2015

Vasuclar endothelial growth factor receptor-3 is a novel target to improve net ultrafiltration in methylglyoxal-induced peritoneal injury.

Terabayashi T, Ito Y, Mizuno M, Suzuki Y, Kinashi H, Sakata F, Tomita T, Iguchi D, Tawada M, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y.

Lab Invest page： in press 2015

Successful Treatment of Cryptococcus laurentii Peritonitis in a Patient on Peritoneal Dialysis International journal

Asano Marina, Mizutani Makoto, Nagahara Yasuko, Inagaki Koji, Kariya Tetsuyoshi, Masamoto Daijiro, Urai Makoto, Kaneko Yukihiro, Ohno Hideaki, Miyazaki Yoshitsugu, Mizuno Masashi, Ito Yasuhiko

Internal Medicine Vol. 54 ( 8 ) page： 941 - 944 2015

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine

A 32-year-old man on peritoneal dialysis (PD) was hospitalized for seven days due to fever. A diagnosis of yeast-like fungal peritonitis was made by Gram staining. The patient was started on intravenous micafungin and oral fluconazole therapy following removal of the PD catheter. A fungal pathogen was isolated from the peritoneal fluid and identified as Cryptococcus species. Based on antifungal susceptibility testing, the treatment was changed to voriconazole and continued for 3 months. A genetic analysis identified the isolate as Cryptococcus laurentii (C. laurentii). This patient was diagnosed with C. laurentii PD-related peritonitis and was successfully treated with voriconazole and removal of the PD catheter.

DOI： 10.2169/internalmedicine.54.3586

A case of difficult hemodialysis induction in a patient with acute intermittent porphyria

Kojima Keitaro, Mizuno Masashi, Hattori Shinichi, Minoshima Kenichi, Yamaha Masayoshi, Horie Masanobu

Nihon Toseki Igakkai Zasshi Vol. 48 ( 7 ) page： 437 - 441 2015

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society for Dialysis Therapy

A 45-year-old female with a history of chronic renal disease attended our hospital in 2008 with acute intermittent porphyria (AIP). The following year, her renal function deteriorated, and her general condition, and clinical and laboratory findings fulfilled the Japanese criteria for hemodialysis. The porphyrias are metabolic disorders of heme biosynthesis that are triggered and worsened by a number of different drugs. Hemodialysis was initiated in 2009, and we prescribed amlodipine besylate and epoetin beta, paying particular attention to drug safety. Currently, the patient is on hemodialysis and is still taking the medications mentioned above, without any exacerbation of porphyria.

DOI： 10.4009/jsdt.48.437

CiNii Research

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Patient Age and the Prognosis of Idiopathic Membranous Nephropathy Reviewed International journal

Yamaguchi Makoto, Ando Masahiko, Yamamoto Ryohei, Akiyama Shinichi, Kato Sawako, Katsuno Takayuki, Kosugi Tomoki, Sato Waichi, Tsuboi Naotake, Yasuda Yoshinari, Mizuno Masashi, Ito Yasuhiko, Matsuo Seiichi, Maruyama Shoichi

PLOS ONE Vol. 9 ( 10 ) page： e110376 2014.10

Level of soluble C5b-9 complex in dialysis fluid may be a predictor of poor prognosis in peritonitis in peritoneal dialysis patients, especially in culture negative peritonitis International coauthorship International journal

Masashi Mizuno, Yasuhiko Ito, Keiko Higashide, Yumi Sei, Daiki Iguchi, Fumiko Sakata, Yasuhiro Suzuki, Isao Ito, Masanobu Horie, B. Paul Morgan, Seiichi Matsuo

MOLECULAR IMMUNOLOGY Vol. 61 ( 2 ) page： 225 - 225 2014.10

腹膜透析排液中の補体活性化産物測定により、腹膜炎の予後を予想できるか?

水野正司, 伊藤恭彦, 東出慶子, 清祐実, 井口大旗, 坂田史子, 鈴木康弘, 堀江正宣, Morgan B. Paul, 松尾清一

補体 Vol. 51 ( 1 ) page： 93 - 94 2014.8

Smoking is a risk factor for the progression of idiopathic membranous nephropathy Reviewed International journal

Makoto Yamaguchi, Masahiko Ando, Ryohei Yamamoto, Shinichi Akiyama, Sawako Kato, Takayuki Katsuno, Tomoki Kosugi, Waichi Sato, Naotake Tsuboi, Yoshinari Yasuda, Masashi Mizuno, Yasuhiko Ito, Seiichi Matsuo, Shoichi Maruyama

PLoS ONE Vol. 9 ( 6 ) page： e100835 2014.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Public Library of Science

Background: Multiple studies have shown cigarette smoking to be a risk factor for chronic kidney disease. However, it is unknown whether smoking similarly increases the risk for progression of membranous nephropathy. Methods: This study used the Nagoya Nephrotic Syndrome Cohort Study (N-NSCS), including 171 patients with idiopathic membranous nephropathy (IMN) from 10 nephrology centers in Japan. The dose-response relationships between cigarette smoking and the outcomes were assessed by using multivariate Cox proportional hazards models adjusted for clinically relevant factors. The primary outcome was a 30% decline in the estimated glomerular filtration rate (eGFR). The secondary outcome was first complete remission (CR) of proteinuria. Results: During the observation period (median, 37 months
interquartile range, 16-71 months), 37 (21.6%) patients developed a 30% decline in eGFR and 2 (1.2%) progressed to ESRD. CR occurred in 103 (60.2%) patients. Multivariate Cox proportional hazards models revealed current smoking (adjusted hazard ratio [HR], 7.81 [95% confidence interval (CI), 3.17- 19.7]), female sex (adjusted HR, 3.58 [95% CI, 1.87-8.00]), older age (adjusted HR, 1.71 [95% CI, 1.13-2.62] per 10 years), the number of cigarettes smoked daily (adjusted HR, 1.61 [95% CI, 1.23-2.09] per 10 cigarettes daily), and cumulative smoking of ≥40 pack-years (adjusted HR, 5.56 [95% CI, 2.17-14.6]) to be associated with a 30% decline in eGFR. However, smoking was not associated with CR. Conclusion: Smoking is a significant and dose-dependent risk factor for IMN progression. All patients with IMN who smoke should be encouraged to quit. © 2014 Yamaguchi et al.

DOI： 10.1371/journal.pone.0100835

ASSOCIATION OF ANKLE BRACHIAL INDEX AND PROTEIN-ENERGY WASTING WITH MORTALITY IN PATIENTS ON HEMODIALYSIS International journal

Keiko, K; Hirotake, K; Ryo, T; Chieko, M; Kiyohito, K; Hirohisa, K; Masashi, M; Yasuhiro, S; Shouichi, M; Yasuhiko, I; Seiichi, M

NEPHROLOGY Vol. 19 page： 178 - 179 2014.5

LYMPHANGIOGENESIS DEVELOPS DURING PERITONEAL FIBROSIS IN RAT PERITONITIS MODELS

Takeshi, T; Yasuhiko, I; Hiroshi, K; Masashi, M; Yasuhiro, S; Fumiko, S; Takako, T; Mitsuhiro, T; Yumi, S; Daiki, I; Seiichi, M

NEPHROLOGY Vol. 19 page： 193 - 193 2014.5

IMPROVEMENT OF PREVALENCE OF PERITONEAL DIALYSIS (PD) THERAPY IN END-STAGE RENAL DISEASE (ESRD) PATIENTS FROM 2010 TO 2012 IN THE TOKAI AREA OF JAPAN. - FIVE YEARS AFTER THE PREVIOUS STUDY

Mizuno Masashi, Ito Yasuhiko, Suzuki Yasuhiro, Saka Yosuke, Hiramatsu Takeyuki, Tamai Hirofumi, Mizutani Makoto, Naruse Tomohiko, Ohashi Norimi, Kasuga Hirotake, Shimizu Hideaki, Kurata Hisashi, Kurata Kei, Suzuki Satoshi, Maruyama Shoichi, Matsuo Seiichi

NEPHROLOGY Vol. 19 page： 113 - 113 2014.5

EXPRESSION OF MEMBRANE COMPLEMENT REGULATORS IN MESOTHERIAL CELLS OF PATIENTS' PERITONEUM ON PERITONEAL DIALYSIS THERAPY

Yumi, S; Masashi, M; Yasuhiro, S; Masaski, I; Keiko, H; Fumiko, S; Daiki, I; Noriko, O; Seiichi, M; Yasuhiko, I

NEPHROLOGY Vol. 19 page： 151 - 151 2014.5

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Papers - MIZUNO, Masashi