Faculty Profiles - MIZUNO, Masashi

Papers - MIZUNO, Masashi

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Smoking is a risk factor for the relapse of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis.

Yamaguchi M., Ando M., Kato S., Katsuno T., Kato N., Kosugi T., Sato W., Tsuboi N., Yasuda Y., Mizuno M., Ito Y., Matsuo S., Maruyama S

J Rheumatology page： in press 2015

Vasuclar endothelial growth factor receptor-3 is a novel target to improve net ultrafiltration in methylglyoxal-induced peritoneal injury.

Terabayashi T, Ito Y, Mizuno M, Suzuki Y, Kinashi H, Sakata F, Tomita T, Iguchi D, Tawada M, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y.

Lab Invest page： in press 2015

Successful Treatment of Cryptococcus laurentii Peritonitis in a Patient on Peritoneal Dialysis International journal

Asano Marina, Mizutani Makoto, Nagahara Yasuko, Inagaki Koji, Kariya Tetsuyoshi, Masamoto Daijiro, Urai Makoto, Kaneko Yukihiro, Ohno Hideaki, Miyazaki Yoshitsugu, Mizuno Masashi, Ito Yasuhiko

Internal Medicine Vol. 54 ( 8 ) page： 941 - 944 2015

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine

A 32-year-old man on peritoneal dialysis (PD) was hospitalized for seven days due to fever. A diagnosis of yeast-like fungal peritonitis was made by Gram staining. The patient was started on intravenous micafungin and oral fluconazole therapy following removal of the PD catheter. A fungal pathogen was isolated from the peritoneal fluid and identified as Cryptococcus species. Based on antifungal susceptibility testing, the treatment was changed to voriconazole and continued for 3 months. A genetic analysis identified the isolate as Cryptococcus laurentii (C. laurentii). This patient was diagnosed with C. laurentii PD-related peritonitis and was successfully treated with voriconazole and removal of the PD catheter.

DOI： 10.2169/internalmedicine.54.3586

A case of difficult hemodialysis induction in a patient with acute intermittent porphyria

Kojima Keitaro, Mizuno Masashi, Hattori Shinichi, Minoshima Kenichi, Yamaha Masayoshi, Horie Masanobu

Nihon Toseki Igakkai Zasshi Vol. 48 ( 7 ) page： 437 - 441 2015

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society for Dialysis Therapy

A 45-year-old female with a history of chronic renal disease attended our hospital in 2008 with acute intermittent porphyria (AIP). The following year, her renal function deteriorated, and her general condition, and clinical and laboratory findings fulfilled the Japanese criteria for hemodialysis. The porphyrias are metabolic disorders of heme biosynthesis that are triggered and worsened by a number of different drugs. Hemodialysis was initiated in 2009, and we prescribed amlodipine besylate and epoetin beta, paying particular attention to drug safety. Currently, the patient is on hemodialysis and is still taking the medications mentioned above, without any exacerbation of porphyria.

DOI： 10.4009/jsdt.48.437

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Patient Age and the Prognosis of Idiopathic Membranous Nephropathy Reviewed International journal

Yamaguchi Makoto, Ando Masahiko, Yamamoto Ryohei, Akiyama Shinichi, Kato Sawako, Katsuno Takayuki, Kosugi Tomoki, Sato Waichi, Tsuboi Naotake, Yasuda Yoshinari, Mizuno Masashi, Ito Yasuhiko, Matsuo Seiichi, Maruyama Shoichi

PLOS ONE Vol. 9 ( 10 ) page： e110376 2014.10

Level of soluble C5b-9 complex in dialysis fluid may be a predictor of poor prognosis in peritonitis in peritoneal dialysis patients, especially in culture negative peritonitis International coauthorship International journal

Masashi Mizuno, Yasuhiko Ito, Keiko Higashide, Yumi Sei, Daiki Iguchi, Fumiko Sakata, Yasuhiro Suzuki, Isao Ito, Masanobu Horie, B. Paul Morgan, Seiichi Matsuo

MOLECULAR IMMUNOLOGY Vol. 61 ( 2 ) page： 225 - 225 2014.10

腹膜透析排液中の補体活性化産物測定により、腹膜炎の予後を予想できるか?

水野正司, 伊藤恭彦, 東出慶子, 清祐実, 井口大旗, 坂田史子, 鈴木康弘, 堀江正宣, Morgan B. Paul, 松尾清一

補体 Vol. 51 ( 1 ) page： 93 - 94 2014.8

Smoking is a risk factor for the progression of idiopathic membranous nephropathy Reviewed International journal

Makoto Yamaguchi, Masahiko Ando, Ryohei Yamamoto, Shinichi Akiyama, Sawako Kato, Takayuki Katsuno, Tomoki Kosugi, Waichi Sato, Naotake Tsuboi, Yoshinari Yasuda, Masashi Mizuno, Yasuhiko Ito, Seiichi Matsuo, Shoichi Maruyama

PLoS ONE Vol. 9 ( 6 ) page： e100835 2014.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Public Library of Science

Background: Multiple studies have shown cigarette smoking to be a risk factor for chronic kidney disease. However, it is unknown whether smoking similarly increases the risk for progression of membranous nephropathy. Methods: This study used the Nagoya Nephrotic Syndrome Cohort Study (N-NSCS), including 171 patients with idiopathic membranous nephropathy (IMN) from 10 nephrology centers in Japan. The dose-response relationships between cigarette smoking and the outcomes were assessed by using multivariate Cox proportional hazards models adjusted for clinically relevant factors. The primary outcome was a 30% decline in the estimated glomerular filtration rate (eGFR). The secondary outcome was first complete remission (CR) of proteinuria. Results: During the observation period (median, 37 months
interquartile range, 16-71 months), 37 (21.6%) patients developed a 30% decline in eGFR and 2 (1.2%) progressed to ESRD. CR occurred in 103 (60.2%) patients. Multivariate Cox proportional hazards models revealed current smoking (adjusted hazard ratio [HR], 7.81 [95% confidence interval (CI), 3.17- 19.7]), female sex (adjusted HR, 3.58 [95% CI, 1.87-8.00]), older age (adjusted HR, 1.71 [95% CI, 1.13-2.62] per 10 years), the number of cigarettes smoked daily (adjusted HR, 1.61 [95% CI, 1.23-2.09] per 10 cigarettes daily), and cumulative smoking of ≥40 pack-years (adjusted HR, 5.56 [95% CI, 2.17-14.6]) to be associated with a 30% decline in eGFR. However, smoking was not associated with CR. Conclusion: Smoking is a significant and dose-dependent risk factor for IMN progression. All patients with IMN who smoke should be encouraged to quit. © 2014 Yamaguchi et al.

DOI： 10.1371/journal.pone.0100835

ASSOCIATION OF ANKLE BRACHIAL INDEX AND PROTEIN-ENERGY WASTING WITH MORTALITY IN PATIENTS ON HEMODIALYSIS International journal

Keiko, K; Hirotake, K; Ryo, T; Chieko, M; Kiyohito, K; Hirohisa, K; Masashi, M; Yasuhiro, S; Shouichi, M; Yasuhiko, I; Seiichi, M

NEPHROLOGY Vol. 19 page： 178 - 179 2014.5

LYMPHANGIOGENESIS DEVELOPS DURING PERITONEAL FIBROSIS IN RAT PERITONITIS MODELS

Takeshi, T; Yasuhiko, I; Hiroshi, K; Masashi, M; Yasuhiro, S; Fumiko, S; Takako, T; Mitsuhiro, T; Yumi, S; Daiki, I; Seiichi, M

NEPHROLOGY Vol. 19 page： 193 - 193 2014.5

IMPROVEMENT OF PREVALENCE OF PERITONEAL DIALYSIS (PD) THERAPY IN END-STAGE RENAL DISEASE (ESRD) PATIENTS FROM 2010 TO 2012 IN THE TOKAI AREA OF JAPAN. - FIVE YEARS AFTER THE PREVIOUS STUDY

Mizuno Masashi, Ito Yasuhiko, Suzuki Yasuhiro, Saka Yosuke, Hiramatsu Takeyuki, Tamai Hirofumi, Mizutani Makoto, Naruse Tomohiko, Ohashi Norimi, Kasuga Hirotake, Shimizu Hideaki, Kurata Hisashi, Kurata Kei, Suzuki Satoshi, Maruyama Shoichi, Matsuo Seiichi

NEPHROLOGY Vol. 19 page： 113 - 113 2014.5

EXPRESSION OF MEMBRANE COMPLEMENT REGULATORS IN MESOTHERIAL CELLS OF PATIENTS' PERITONEUM ON PERITONEAL DIALYSIS THERAPY

Yumi, S; Masashi, M; Yasuhiro, S; Masaski, I; Keiko, H; Fumiko, S; Daiki, I; Noriko, O; Seiichi, M; Yasuhiko, I

NEPHROLOGY Vol. 19 page： 151 - 151 2014.5

Rat adipose tissue-derived stem cells attenuate peritoneal injuries in rat zymosan-induced peritonitis accompanied by complement activation Reviewed International journal

Kim Hangsoo, Mizuno Masashi, Furuhashi Kazuhiro, Katsuno Takayuki, Ozaki Takenori, Yasuda Kaoru, Tsuboi Naotake, Sato Waichi, Suzuki Yasuhiro, Matsuo Seiichi, Ito Yasuhiko, Maruyama Shoichi

CYTOTHERAPY Vol. 16 ( 3 ) page： 357 - 368 2014.3

Long-term effects of spironolactone in peritoneal dialysis patients. Reviewed

Ito Y., Mizuno M., Suzuki Y., Tamai G., Hiramatsu T.,Ohashi H., Ito I., Kasuga H., Horie M., Maruyama S., Yuzawa Y., Matsubara T., Matsuo S, Nagoya Spiro Study Group.

J Am Soc Nephrol page： in press 2014

Smoking is a risk factor for the progression of idiopathic membranous nephropathy. Reviewed

Yamaguchi M., Ando M., Yamamoto R., Akiyama S., Kato S., Katsuno T., Kosugi T., Sato W., Tsuboi N., Yasuda Y., Mizuno M., Ito Y., Matsuo S., Maruyama S.

PloS One Vol. ９ ( ６ ) page： e100835 2014

Patient age and the prognosis of idiopathic membrane nephropathy. Reviewed

Yamaguchi M., Ando M., Yamamoto R., Akiyama S., Kato S., Katsuno T., Kosugi T., Sato W., Tsuboi N., Yasuda Y., Mizuno M., Ito Y., Matsuo S., Maruyama S.

ProsOne Vol. 9 ( 10 ) page： e110376 2014

Future Expectations of Diagnostic Approaches for Treating Endogenous Peritonitis in Patients on Peritoneal Dialysis Reply International journal

Masashi Mizuno, Yasuhiro Suzuki, Yasuhiko Ito

INTERNAL MEDICINE Vol. 53 ( 6 ) page： 647 - 647 2014

Expression of membrane complement regulators in patients on peritoneal dialysis therapy International coauthorship International journal

Sei, Y; Mizuno, M; Imai, M; Suzuki, Y; Higashide, K; Okada, N; Harris, C; Matsuo, S; Ito, Y

MOLECULAR IMMUNOLOGY Vol. 56 ( 3 ) page： 277 - 278 2013.12

Anti-C5a complementary peptide ameliorates acute peritoneal injury induced by neutralization of Crry and CD59 Reviewed International journal

Tomohiro Mizuno, Masashi Mizuno, Masaki Imai, Yasuhiro Suzuki, Mayu Kushida, Yukihiro Noda, Shoichi Maruyama, Hidechika Okada, Noriko Okada, Seiichi Matsuo, Yasuhiko Ito

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY Vol. 305 ( 11 ) page： F1603 - F1616 2013.12

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：AMER PHYSIOLOGICAL SOC

In peritoneal dialysis (PD) therapy, physical stresses such as exposure to peritoneal dialysate, catheter trauma, and peritonitis may induce peritoneal injury that can prevent continued long-term PD therapy. Therefore, protection of the peritoneum is an important target to enable long-term PD therapy in patients with end-stage renal disease. We previously showed that neutralization of the membrane complement regulators (CRegs) Crry and CD59 in rat peritoneum provokes development of acute peritoneal injury due to uncontrolled complement activation. C5a is a key effecter molecule of the complement system released during acute inflammation. Control of C5a has been proposed as a strategy to suppress inflammatory reactions and, because peritoneal injury is accompanied by inflammation, we hypothesized that C5a targeted therapy might be an effective way to suppress peritoneal injury. In the present study we used an established acute peritonitis model induced by neutralization of CRegs to investigate the effects on acute peritoneal injury of inhibiting C5a. Intravenous administration of an anti-C5a complementary peptide (AcPepA) up to 4 h after induction of injury significantly and dose-dependently prevented accumulation of inflammatory cells and reduced tissue damage in the model, accompanied by decreased C3b deposition. We show that C5a contributed to the development of peritoneal injury. Our results suggest that C5a is a target for preventing or treating peritoneal injury in patients undergoing prolonged PD therapy or with infectious complications.

DOI： 10.1152/ajprenal.00681.2012

Web of Science

PubMed

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TGF-β1 promotes lymphangiogenesis during peritoneal fibrosis.

Kinashi H, Ito Y, Mizuno M, Suzuki Y, Terabayashi T, Nagura F, Hattori R, Matsukawa Y, Mizuno T, Noda Y, Nishimura H, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y

Journal of the American Society of Nephrology : JASN Vol. 24 ( 10 ) page： 1627 - 42 2013.10

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Papers - MIZUNO, Masashi