Faculty Profiles - MIZUNO, Masashi

Papers - MIZUNO, Masashi

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Membrane complement regulators protect against the development of type II collagen-induced arthritis in rats Reviewed International coauthorship International journal

M Mizuno, K Nishikawa, OB Spiller, BP Morgan, N Okada, H Okada, S Matsuo

ARTHRITIS AND RHEUMATISM Vol. 44 ( 10 ) page： 2425 - 2434 2001.10

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-LISS

Objective. To investigate changes in the distribution patterns of membrane complement regulators (MCRs) during the development of type II collagen-induced arthritis (CIA) and to examine the protective effects of these molecules against the augmentation of CIA in the knee joint.
Methods. Immunohistochemistry was used to examine the distribution of the MCRs Crry, DAF, and CD59 in the synovium of knee joints before and 2, 4, and 10 weeks after induction of CIA by immunization with type II collagen. In addition, at 2 or 10 weeks after induction of CIA, rats were injected intraarticularly with anti-Crry and/or anti-CD59 as the F(ab')(2) fraction of monoclonal antibodies (mAb). Knee joint swelling and histologic changes in the synovium were examined 2 weeks after mAb injection.
Results. Synovial expression of Crry, DAF, and CD59 decreased in parallel with increased inflammation. When Crry and CD59 were functionally blocked at 2 weeks after the induction of CIA, swelling of the knee joints was markedly increased. Blocking of either regulator alone had no effect on swelling. Thickening of the synovial surface and proliferation of subsynovial tissue were all increased after blocking Crry and CD59, whereas blocking of either MCR alone had no effect. When both Crry and CD59 were blocked, deposits of membrane attack complex were found in the synovium.
Conclusion. Our findings indicate that in rats with CIA and severely inflamed synovium, local expression of MCR is reduced. The MCRs Crry and CD59 appear to suppress the development of CIA.

DOI： 10.1002/1529-0131(200110)44:10<2425::AID-ART407>3.0.CO;2-4

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The role of C5a in the development of thrombotic glomerulonephritis in rats

Kondo C, Mizuno M, Nishikawa K, Yuzawa Y, Hotta N, Matsuo S

CLINICAL AND EXPERIMENTAL IMMUNOLOGY Vol. 124 ( 2 ) page： 323 - 329 2001.5

The role of C5a in the development of thrombotic glomerulonephritis in rats. Reviewed International journal

Kondo C, Mizuno M, Nishikawa K, Yuzawa Y, Hotta N, Matsuo S

Clinical and experimental immunology Vol. 124 ( 2 ) page： 323 - 9 2001.5

Glomerulocystic kidney associated with subacute necrotizing-encephalomyelopathy Reviewed International journal

T Yamakawa, F Yoshida, T Kumagai, H Watanabe, A Takano, M Mizuno, H Ikeguchi, Y Morita, G Sobue, S Matsuo

AMERICAN JOURNAL OF KIDNEY DISEASES Vol. 37 ( 2 ) page： E14 2001.2

Language：English Publishing type：Research paper (scientific journal) Publisher：W B SAUNDERS CO

A 22-year-old man with subacute necrotizing-encephalomyelopathy (SNE; Leigh's disease) was diagnosed as having progressive renal dysfunction. The clinical diagnosis of Leigh's disease was obtained by the typical central nervous lesions, abnormalities in other organs, and increased lactate concentrations in blood and cerebrospinal fluid. We performed an open biopsy of the right kidney. Light microscopic studies of the renal specimen showed diffuse glomerulocystic kidney (GCK) with tubulointerstitial damage. Electron microscopic examination showed marked swelling and increase in the number of mitochondria of the renal tubular epithelial cells. Therefore, it is suggested that mitochondrial disease seems to play an important role in developing GCK. (C) 2001 by the National Kidney Foundation, Inc.

DOI： 10.1053/ajkd.2001.21358

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【尿蛋白と尿細管障害】　尿中補体成分と尿細管障害 Invited

松尾清一, 森田良樹, 水野正司

細胞 Vol. 33 page： 12-15 2001

【Innate immunity】　臨床　補体制御因子と疾患 Reviewed

松尾清一, 水野正司

現代医療 Vol. 33 page： 1011-1016 2001

Glomerulocystic Kidney Associated With Subacute Necrotizing-Encephalomyelopathy. Reviewed

Yamakawa T., Yoshida H., Kumagai T., Watanabe H., Takano A., Mizuno M., Ikeguchi H., Morita Y., Sobue G., Matsuo S.

Am. J. Kidney Dis. Vol. 37 page： E14 2001

Blockage of complement regulators in the conjunctiva and within the eye leads to massive inflammation and iritis. Reviewed

Bardenstein SD., Cheyer JC, Lee C., Cocuzzi E., Mizuno M., Okada N., Medof EM.

Immunology Vol. 104 page： 423-430 2001

Membrane complement regulators protect against the development of type II collagen-induced arthritis (CIA) in rats. Reviewed

Mizuno M., Nishikawa K., Spiller OB., Morgan BP., Okada N., Okada H., Matsuo S.

Arthritis Rheum. Vol. 44 page： 2425-2434 2001

The effects of a new synthetic selectin blocker in an acute rat thrombotic glomerulonephritis. Reviewed

Ito I., Yuzawa Y., Mizuno M., Nishikawa K., Jomori T., Tashita A., Hotta N., Matsuo S.

Am. J. Kidney Dis. Vol. 38 page： 265-273 2001

The Role of C5a in The Development of Thrombotic Glomerulonephritis in Rats. Reviewed

Kondo C., Mizuno M., Nishikawa K., Yuzawa Y., Hotta N., Matsuo S.

Clin. Exp. Immunol. Vol. 124 page： 323-329 2001

【尿蛋白と尿細管障害】尿中補体成分と尿細管障害 Invited

松尾清一, 森田良樹, 水野正司

細胞 Vol. 33 ( 1 ) page： 12-15 - 15 2001

Acute renal failure after a sea anemone sting Reviewed International journal

M Mizuno, K Nishikawa, Y Yuzawa, T Kanie, H Mori, Y Araki, N Hotta, S Matsuo

AMERICAN JOURNAL OF KIDNEY DISEASES Vol. 36 ( 2 ) page： art. no. - E10 2000.8

Language：English Publishing type：Research paper (scientific journal) Publisher：W B SAUNDERS CO

A 27-year-old man suffering from severe swelling and pain in his right arm was referred to our hospital. He showed signs of acute renal failure (ARF) with severe dermatitis of his right arm. Three days before being admitted, he accidentally touched some kind of marine organism with his right hand while snorkeling in the Sulu Sea around Cebu Island. Within a few minutes, he was experiencing severe pain in his right hand. Then his right hand gradually became swollen. The marine creature responsible for this injury was thought to have been a sea anemone, which is a type of coelenterate. Histologic findings of a renal biopsy indicated that acute tubular necrosis (ATN) had caused ARF in this patient's case. Supportive therapies improved renal function of this patient, and steroid pulse therapy attenuated the severe skin discoloration. The ATN was thought to have been caused by the poison from a sea anemone because there were no other conceivable reasons for the patient's condition. This is the first time that a marine envenomation case has been reported in which the sting of a sea anemone has caused ATN without the failure of any other organs. (C) 2000 by the National Kidney Foundation, Inc.

DOI： 10.1053/ajkd.2000.9006

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Abolition of anti-glomerular basement membrane antibody-mediated glomerulonephritis in FcRgamma-deficient mice. Reviewed International journal

Wakayama H, Hasegawa Y, Kawabe T, Hara T, Matsuo S, Mizuno M, Takai T, Kikutani H, Shimokata K

European journal of immunology Vol. 30 ( 4 ) page： 1182 - 90 2000.4

Comparison of the suppressive effects of soluble CR1 and C5a receptor antagonist in acute arthritis induced in rats by blocking of CD59 Reviewed International coauthorship

Mizuno M, Nishikawa K, Morgan BP, Matsuo S

CLINICAL AND EXPERIMENTAL IMMUNOLOGY Vol. 119 ( 2 ) page： 368 - 375 2000.2

Comparison of the suppressive effects of soluble CR1 and C5a receptor antagonist in acute arthritis induced in rats by blocking of CD59. Reviewed International coauthorship International journal

Mizuno M, Nishikawa K, Morgan BP, Matsuo S

Clinical and experimental immunology Vol. 119 ( 2 ) page： 368 - 75 2000.2

Abolition of anti-glomerular basement membrane antibody-mediated glomerulonephritis in FcRgamma-deficient mice. Reviewed

Wakayama H., Hasegawa Y., Kawabe T., Hara T., Matsuo S., Mizuno M., Takai T., Kikutani H., Shimokata K.

Eur. J. Immunol. Vol. 30 page： 1182-1190 2000

Comparison of the suppressive effects of soluble CR1 and C5a receptor antagonist in acute arthritis induced by anti-rat CD59 antibody. Reviewed

Mizuno M., Nishikawa K., Morgan B.P., Matsuo S.

Clin. Exp. Immunol. Vol. 119 page： 368-375 2000

A case report of acute renal failure following a sting presumedly by a sea anemone. Reviewed

Mizuno M., Nishikawa K., Yuzawa Y., Kanie T., Mori H., Araki Y., Hotta N., Matsuo S.

Am. J. Kidney Dis. Vol. 36 page： E10 2000

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

【腎臓病の分子生物学】　腎障害のメディエータ　補体制御による進行性腎疾患治療の可能性

松尾清一, 水野正司

医学のあゆみ Vol. 193 page： 32-35 2000

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