Faculty Profiles - MIZUNO, Masashi

Papers - MIZUNO, Masashi

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【腎臓病の分子生物学】　腎障害のメディエータ　補体制御による進行性腎疾患治療の可能性

松尾清一, 水野正司

医学のあゆみ Vol. 193 page： 32-35 2000

【急性腎不全の全て-2000】　病因・病態　急性腎不全とサイトカイン Invited

松尾清一, 水野正司

腎と透析 Vol. 49 page： 373-376 2000

A case report of acute renal failure following a sting presumedly by a sea anemone. Reviewed

Mizuno M., Nishikawa K., Yuzawa Y., Kanie T., Mori H., Araki Y., Hotta N., Matsuo S.

Am. J. Kidney Dis. Vol. 36 page： E10 2000

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

A 27-year-old man suffering from severe swelling and pain in his right arm was referred to our hospital. He showed signs of acute renal failure (ARF) with severe dermatitis of his right arm. Three days before being admitted, he accidentally touched some kind of marine organism with his right hand while snorkeling in the Sulu Sea around Cebu Island. Within a few minutes, he was experiencing severe pain in his right hand. Then his right hand gradually became swollen. The marine creature responsible for this injury was thought to have been a sea anemone, which is a type of coelenterate. Histologic findings of a renal biopsy indicated that acute tubular necrosis (ATN) had caused ARF in this patient's case. Supportive therapies improved renal function of this patient, and steroid pulse therapy attenuated the severe skin discoloration. The ATN was thought to have been caused by the poison from a sea anemone because there were no other conceivable reasons for the patient's condition. This is the first time that a marine envenomation case has been reported in which the sting of a sea anemone has caused ATN without the failure of any other organs.

The role of complement in the progression of renal fibrosis: a clinical study. Invited Reviewed

Matsuo S., Morita Y., Mizuno M., Nishikawa K., Yuzawa Y.

Nephrol. Dial. Transplant. Vol. 15 page： 53-54 2000

CD59 protects kidneys from complement mediated injury in collaboration with Crry in rats. Reviewed

Watanabe M., Morita Y., Mizuno M., Nishikawa K., Yuzawa Y., Hotta N., Morgan B.P., Okada N., Okada H., Matsuo S.

Kidney Int. Vol. 58 page： 1569-1579 2000

Abolition of anti-glomerular basement membrane antibody-mediated glomerulonephritis in FcRgamma-deficient mice. Reviewed

Wakayama H., Hasegawa Y., Kawabe T., Hara T., Matsuo S., Mizuno M., Takai T., Kikutani H., Shimokata K.

Eur. J. Immunol. Vol. 30 page： 1182-1190 2000

Comparison of the suppressive effects of soluble CR1 and C5a receptor antagonist in acute arthritis induced by anti-rat CD59 antibody. Reviewed

Mizuno M., Nishikawa K., Morgan B.P., Matsuo S.

Clin. Exp. Immunol. Vol. 119 page： 368-375 2000

The role of complement in the progression of renal fibrosis: a clinical study Invited Reviewed International journal

S Matsuo, Y Morita, M Mizuno, K Nishikawa, Y Yuzawa

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 15 page： 53 - 54 2000

A case report of acute renal failure following a sting presumedly by a sea anemone. Reviewed

Mizuno M, Nishikawa K, Yuzawa Y, Kanie T, Mori H, Araki Y, Hotta N, Matsuo S

Am. J. Kidney Dis. Vol. 36 page： E10 2000

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

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The role of complement in the progression of renal fibrosis: a clinical study. Reviewed International journal

Matsuo S, Morita Y, Mizuno M, Nishikawa K, Yuzawa Y

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Vol. 15 Suppl 6 page： 53 - 4 2000

Direct Gram staining of blood culture sample enabled the early diagnosis of brain abscess due to Listeria monocytogenes Reviewed

TAKANO Akemi, ADACHI Hiroaki, MIZUNO Masashi, KAWAMURA Kumiko, SOBUE Gen

Rinsho Shinkeigaku (Clin Neurol) Vol. 39 ( 11 ) page： 1164 - 1167 1999.11

Inhibition of a membrane complement regulatory protein by a monoclonal antibody induces acute lethal shock in rats primed with lipopolysaccharide Reviewed International journal

M Mizuno, K Nishikawa, N Okada, S Matsuo, K Ito, H Okada

JOURNAL OF IMMUNOLOGY Vol. 162 ( 9 ) page： 5477 - 5482 1999.5

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：AMER ASSOC IMMUNOLOGISTS

Rats pretreated with traces of LPS developed acute fatal shock syndrome after i.v. administration of a mAb that inhibits the function of a membrane complement regulatory molecule, Such a shock was not observed after the administration of large amounts of LPS instead of the mAb following LPS pretreatment. The lethal response did not occur in rats depleted of either leukocytes or complement, and a C5a receptor antagonist was found to inhibit the reaction. Furthermore, LPS-treated rats did not suffer fatal shock following the injection of cobra venom factor, which activates complement in the fluid phase so extensively as to exhaust complement capacity, Therefore, complement activation on cell membranes is a requirement for this type of acute reaction.

Web of Science

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Inhibition of a membrane complement regulatory protein by a monoclonal antibody induces acute lethal shock in rats primed with lipopolysaccharide. Reviewed International journal

Mizuno M, Nishikawa K, Okada N, Matsuo S, Ito K, Okada H

Journal of immunology (Baltimore, Md. : 1950) Vol. 162 ( 9 ) page： 5477 - 82 1999.5

血液培養サンプルのグラム染色により早期診断が可能であったリステリア脳膿瘍の1例 Reviewed

高野明美, 足立弘明, 水野正司, 川村久美子, 祖父江元

臨床神経学 Vol. 39 page： 1164-1167 1999

Functional inhibition of a membrane complement regulatory protein induces lethal shock in rats primed with trace levels of lipopolysaccharide. Reviewed

Mizuno M., Nishikawa K., Okada N., Mastuo S., Okada H., Ito K., Okada H.

J. Immunol. Vol. 162 page： 5477-5482 1999