Faculty Profiles - MIZUNO, Masashi

Papers - MIZUNO, Masashi

Division display 181 - 200 of about 334 ／ All the affair displays >>

Non-physiological osmolarity and pH in peritoneal dialysis fluid impair complement regulation in rat peritoneal mesothelial cells International coauthorship International journal

Mizuno, M; Mizuno, T; Ito, Y; Suzuki, Y; Kinashi, H; Noda, Y; Yamada, K; Okada, N; Morgan, BP; Matsuo, S

MOLECULAR IMMUNOLOGY Vol. 48 ( 14 ) page： 1690 - 1690 2011.8

Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients. Reviewed

Sawai A, Ito Y, Mizuno M, Suzuki Y, Toda S, Ito I, Hattori R, Matsukawa Y, Gotoh M, Takei Y, Yuzawa Y, Matsuo S

Vol. 26 ( 7 ) page： 2322-2332 2011.7

Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients Reviewed International journal

Sawai Akiho, Ito Yasuhiko, Mizuno Masashi, Suzuki Yasuhiro, Toda Susumu, Ito Isao, Hattori Ryohei, Matsukawa Yoshihisa, Gotoh Momokazu, Takei Yoshifumi, Yuzawa Yukio, Matsuo Seiichi

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 26 ( 7 ) page： 2322 - 2332 2011.7

Specific collaboration between rat membrane complement regulators Crry and CD59 protects peritoneum from damage by autologous complement activation Reviewed International coauthorship International journal

Tomohiro Mizuno, Masashi Mizuno, B. Paul Morgan, Yukihiro Noda, Kiyofumi Yamada, Noriko Okada, Yukio Yuzawa, Seiichi Matsuo, Yasuhiko Ito

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 26 ( 6 ) page： 1821 - 1830 2011.6

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：OXFORD UNIV PRESS

Background. The peritoneal cavity is isolated from the outside and is usually a sterile environment. Patients on peritoneal dialysis (PD) have PD fluid (PDF) infused into the peritoneal cavity. We previously showed that unregulated complement activation could contribute to the development of peritoneal inflammation in yeast peritonitis in PD therapy. In that situation, suppression of local complement activation is essential to protect the host from further injury. The membrane complement regulators (CRegs), Crry, CD55 and CD59, are expressed in the rat peritoneum, especially along the mesothelial cell layer.
Methods. We investigated CRegs' functional roles in the peritoneal cavity using blocking mAb against each CReg and complement activation in different PDFs.
Results. Blockade of any single CReg did not cause spontaneous peritoneal injury in rat. Combined blockade of Crry and CD59 induced focal peritoneal tissue injury and heavy accumulation of inflammatory cells with peritoneal edema at 24 h. Deposits of C3 and C5b-9 were found on the peritoneal surface after combined blocking of Crry and CD59. Systemic complement depletion by cobra venom factor abrogated these inflammatory changes. When combined blockade of Crry and CD59 was performed with PDF of different pH and glucose concentration in rats, the peritoneal injuries were enhanced with lower pH and higher glucose concentration. These results were confirmed by in vitro experiments using primary rat mesothelial cell culture.
Conclusions. Rat CRegs, Crry and CD59, specifically collaborate to control complement activation in rat peritoneum. During PD, impairment of CReg might contribute to the development of severe peritoneal inflammation.

DOI： 10.1093/ndt/gfq683

Web of Science

PubMed

researchmap

A case of fulminant peritonitis caused by Streptococcus mitis in a patient on peritoneal dialysis. Reviewed

Mizuno M., Ito Y, Masuda T, Toda S, Hiramatsu H, Suzuki Y, Ozaki T, Yasuda Y, Ito I, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S.

Intern Med Vol. 50 page： 471-474 2011

Lymphangiogenesis develop during tubulo-interstitial fibrosis via TGF-beta VEGF-C pathway in rat unilateral ureteral obstruction. Reviewed

Suzuki Y, Ito Y, Mizuno M, Sawai A, Kinashi H, Noda Y, Kato H, Shimizu H, Fujita Y, Matsui K, Imai E, Yuzawa Y, Matsuo S, Takei Y.

Kidney Int Vol. ??? in press page： ???????? 2011

Asymptomatic diverticulosis identified by computed tomography is not a risk factor for enteric peritonitis. Reviewed

Toda S, Ito Y, Mizuno M, Suzuki Y, Ito I, Hiramatsu H, Ozaki T, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S.

Nephrol Dial Transplant Vol. ?? page： ?????? in press 2011

A case of perforative peritonitis by a piece of bamboo in a patient on peritoneal dialysis. Reviewed

Suzuki Y., Mizuno M., Nakashima R., Hiramatsu H., Toda S., Sato W., Tsuboi N., Ito I., Maruyama S., Imai E., Matsuo S., Ito Y.

Clin Exp Nephrol Vol. 15 page： 962-965 2011

A case of acute renal failure caused by cholesterol embolization after carotid artery stenting that was improved by peritoneal dialysis. Reviewed

Mizuno M., Ito Y., Hayasaki T., Suzuki Y., Hiramatsu H., Toda S., Tatematsu M., Ozaki T., Sato W., Tsuboi N., Ito I., Marumaya S., Imai E., Matsuo S.

Intern Med Vol. 50 page： 1719-1723 2011

A case of acute renal failure caused by cholesterol embolization after carotid artery stenting that was improved by peritoneal dialysis. Reviewed

Mizuno M., Ito Y., Hayasaki T., Suzuki Y., Hiramatsu H., Toda S., Tatematsu M., Ozaki T., Sato W., Tsuboi N., Ito I., Marumaya S., Imai E., Matsuo S.

Intern Med Vol. 50 page： 1719-1723 2011

腹膜透析にかかわる腹膜組織障害における補体の関与 Invited

水野正司、伊藤恭彦、松尾清一

医学のあゆみ Vol. 239 page： 779-783 2011

残腎機能を有する腹膜透析患者に対するシナカルセト投与時のMg、K代謝に及ぼす影響 Reviewed

柴田佳菜子、伊藤恭彦、水野正司、鈴木康弘、平松英樹、伊藤功、戸田晋、丸山彰一、中尾誠、松尾清一

日本透析医学会会誌 Vol. 44 page： 1007-1013 2011

A Case of Fulminant Peritonitis Caused by Streptococcus mitis in a Patient on Peritoneal Dialysis Reviewed International journal

Mizuno Masashi, Ito Yasuhiko, Masuda Tomohiro, Toda Susumu, Hiramatsu Hideki, Suzuki Yasuhiro, Ozaki Takenori, Yasuda Yoshinari, Ito Isao, Tsuboi Naotake, Sato Waichi, Maruyama Shoichi, Imai Enyu, Matsuo Seiichi

Internal Medicine Vol. 50 ( 5 ) page： 471 - 474 2011

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine

A 54-year-old woman on peritoneal dialysis (PD) was hospitalized with peritonitis with a high body temperature, abdominal pain and cloudy peritoneal fluid. She progressively fell into septic-like shock within only 6 hours after onset. The causative bacteria were Streptococcus mitis (S. mitis), part of the normal flora of oral cavity, intestine, female genial tract and upper respiratory tract. S. mitis shows pathogenicity for diseases such as endocarditis, brain abscesses and sepsis in children with malignancy or transplantation. However, S. mitis rarely shows severe pathogenic responses in adults. We report herein a case of fulminant peritonitis caused by S. mitis in an adult PD patient.

DOI： 10.2169/internalmedicine.50.4122

Effects of cinacalcet on magnesium and potassium metabolism in peritoneal dialysis patients with residual renal function International journal

Shibata Kanako, Ito Yasuhiko, Mizuno Masashi, Suzuki Yasuhiro, Hiramatsu Hideki, Ito Isao, Toda Susumu, Maruyama Shoichi, Matsuo Seiichi

Nihon Toseki Igakkai Zasshi Vol. 44 ( 10 ) page： 1007 - 1013 2011

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society for Dialysis Therapy

Cinacalcet, a calcimimetic agent, binds to the calcium-sensing receptor (CaSR) and effectively decreases parathyroid hormone (PTH) secretion. CaSR is expressed in organs such as the parathyroid, kidneys, and bone. In the kidneys, it is expressed in the thick ascending limb (TAL) and the distal tubule (DT). In the TAL, activation of CaSR inhibits magnesium and calcium resorption by direct or indirect mechanisms. It also inhibits recycling of potassium back into the lumen by potassium channels. Peritoneal dialysis (PD) is thought to preserve the residual renal function (RRF) longer than hemodialysis. RRF is thus an important prognostic factor for PD patients. We investigated the effects on electrolyte balance and safety of cinacalcet. Six PD patients with RRF received once-daily oral cinacalcet at 25mg for two months. We examined the changes in levels of serum iPTH, and serum and urinary excretion of phosphorus, calcium, magnesium, and potassium for two months. Median (interquatile range: IQR) serum iPTH levels decreased significantly from 427.2 (351.2~1,313.3) pg/mL to 234.4 (86.0~721.3) pg/mL. Serum phosphorus levels and urinary excretion of phosphorus also decreased significantly. In contrast, concentrations of serum calcium, magnesium, and potassium, and urinary excretion of calcium, magnesium, and potassium did not change significantly. Serum levels of magnesium and potassium were not significantly altered, and were within the normal ranges (before, median 2.2 (IQR: 1.9~2.3) mg/dL, after, median 2.0 (IQR: 1.8~2.5) mg/dL for Mg; and before, median 4.5 (IQR: 4.4~5.2) mEq/L to 4.6 (IQR: 4.2~4.8) mEq/L for K). Based on these findings regarding the potassium and magnesium balance, cinacalcet appears to be useful and safe for the treatment of secondary hyperparathyroidism in PD patients with RRF.

DOI： 10.4009/jsdt.44.1007

CiNii Research

A Case of Acute Renal Failure Caused by Cholesterol Embolization after Carotid Artery Stenting that was Improved by Peritoneal Dialysis International journal

Mizuno Masashi, Ito Yasuhiko, Hayasaki Takahiro, Suzuki Yasuhiro, Hiramatsu Hideki, Toda Susumu, Mizuno Tomohiro, Tatematsu Miho, Ozaki Takenori, Yasuda Yoshinari, Sato Waichi, Tsuboi Naotake, Ito Isao, Maruyama Shoichi, Imai Enyu, Matsuo Seiichi

Internal Medicine Vol. 50 ( 16 ) page： 1719 - 1723 2011

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine

A 68-year-old man was admitted with acute renal failure caused by cholesterol embolization after undergoing carotid artery stenting. Hemodialysis therapy (HD) was immediately required because of uremia, using nafamostat mesilate as an anticoagulant for HD. However, blue toes and gangrene of the feet worsened. To prevent use of anticoagulants and stabilize BP, HD was changed to peritoneal dialysis (PD). After starting PD, blue toes and gangrene improved markedly. Residual renal function also partially recovered. Although BP was unstable during HD, stability of BP and avoidance of anticoagulants during PD therapy might have contributed to the good results.

DOI： 10.2169/internalmedicine.50.5358

Asymptomatic diverticulosis identified by computed tomography is not a risk factor for enteric peritonitis. Reviewed International journal

Toda S, Ito Y, Mizuno M, Suzuki Y, Ito I, Hiramatsu H, Ozaki T, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S

Nephrol Dial Transplant Vol. ?? page： ?????? in press 2011

残腎機能を有する腹膜透析患者に対するシナカルセト投与時のMg、K代謝に及ぼす影響 Reviewed

柴田佳菜子, 伊藤恭彦, 水野正司, 鈴木康弘, 平松英樹, 伊藤功, 戸田晋, 丸山彰一, 中尾誠, 松尾清一

日本透析医学会会誌 Vol. 44 page： 1007-1013 2011

Pathological changes in chronic eosinophilic peritonitis in peritoneal dialysis patient. Reviewed International journal

Yuzawa Y, Ito Y, Mizuno M, Sawai A, Matsuo S

NDT plus Vol. 3 ( 4 ) page： 372 - 5 2010.8

Membrane complement regulators may protect against encapsular peritoneal sclerosis (EN) in a chronic proliferative peritoneal inflammation model of zymosan peritonitis in the rat International coauthorship International journal

Masashi Mizuno, Yasuhiko Ito, Tomohiro Mizuno, Yasuhiro Suzuki, Yukihiro Noda, Kiyofumi Yamada, Claire L. Harris, Noriko Okada, B. Paul Morgan, Seiichi Matsuo

MOLECULAR IMMUNOLOGY Vol. 47 ( 13 ) page： 2270 - 2270 2010.8

[Recent knowledge of complement system and the protective roles]. Invited

Mizuno M, Matsuo S

Nihon rinsho. Japanese journal of clinical medicine Vol. 68 Suppl 6 page： 49 - 52 2010.6

　 PREV - NEXT 　

<MIZUNO, Masashi>

Papers - MIZUNO, Masashi