Faculty Profiles - MIZUNO, Masashi

Papers - MIZUNO, Masashi

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遺伝子組換えヒトエリスロポエチンによる赤血球造血刺激因子製剤療法低反応性腹膜透析患者の持続型赤血球層血刺激因子製剤Darbepoetin Alfa投与の効果 Reviewed Open Access

平松英樹、林祐樹、水野正司、鈴木康弘、戸田晋、伊藤功、丸山彰一、伊藤恭彦、松尾清一

日本透析医学会会誌 Vol. 45 page： 247-253 2012

各論２　腹膜透析ガイドライン, 3. 腹膜炎管理 ISPDガイドラインを本邦の実地臨床にいかに活用するか？本邦のガイドラインをいかにすべきか？ Invited

伊藤恭彦、水野正司、鈴木康弘、清祐実、平松英樹、松尾清一

臨床透析 Vol. 28 page： 856-864 2012

至摘透析・体液管理, 腹膜透析における小・中・大分子量物質除去と腹膜機能の関連性

5. 平松英樹、伊藤恭彦、水野正司、鈴木康弘、戸田晋、坪井直毅、伊藤功、佐藤和一、丸山彰一、今井圓裕、林裕樹、松尾清一

腎と透析 2012 （腎と透析　別冊） Vol. 73 page： 235-236 2012

IV. 課題と対策（２）腹膜炎 - 名古屋大学関連施設レジストリーからみたPD腹膜炎の問題点. Invited

伊藤恭彦、水野正司、鈴木康弘、他

臨床と透析 Vol. 28 page： 571-577 2012

腹膜組織における補体活性化の観点からみた、現在の透析液の問題

水野正司、伊藤恭彦、鈴木康弘、松尾清一

腎と透析 2012 （腎と透析　別冊） Vol. 73 page： 109-110 2012

Adequate administration of darbepoetin alfa improves renal anemia in Japanese peritoneal dialysis patients for whom the maximum dose of recombinant human erythropoietin did not fully achieve improved anemia International coauthorship

Hiramatsu Hideki, Hayashi Hiroki, Mizuno Masashi, Suzuki Yasuhiro, Toda Susumu, Ito Isao, Maruyama Shoichi, Ito Yasuhiko, Matsuo Seiichi

Nihon Toseki Igakkai Zasshi Vol. 45 ( 3 ) page： 247 - 253 2012

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society for Dialysis Therapy

Although the maximum approved dosage of recombinant human erythropoietin (rHuEPO) is 24,000IU/month in patients on peritoneal dialysis (PD) therapy in Japan, the improvement of renal anemia is not always satisfactorily maintained at a blood hemoglobin (Hb) level>10.0g/dL. Among 46 patients on PD therapy in our hospital, we investigated the effects of darbepoetin alfa (DA) in 8 patients (DA group) with Hb<10.0g/dL after the administration of rHuEPO at 12,000IU/2 weeks, compared with the 38 other patients (non-DA group) with Hb>10.0g/dL after the administration of rHuEPO at a dose<12,000IU/2 weeks. In terms of background data, the residual renal function was lower and serumβ<SUB>2</SUB> microglobulin level was higher in the DA group, compared with the non-DA group. As an inflammatory marker, the serum C-reactive protein level was also higher in the DA group than in the non-DA group. After 18 weeks of DA administration instead of rHuEPO, the mean (±standard deviation) Hb level increased to 11.0±0.8g/dL. The Hb level eventually reached>10.0g/dL in all patients using DA instead of rHuEPO. Of note, serum ferritin levels in all 46 patients were within the normal range, suggesting that low iron storage was not a direct reason for anemia in this study. The present results suggest that renal anemia in patients on PD therapy who remained inadequately managed using the maximum approved dosage of rHuEPO was caused by an inadequate dosage of rHuEPO, and might be controlled to target levels using an adequate dosage of DA.

DOI： 10.4009/jsdt.45.247

CiNii Research

Combined Values of Serum Albumin, C-Reactive Protein and Body Mass Index at Dialysis Initiation Accurately Predicts Long-Term Mortality Reviewed International journal

Takahashi Ryo, Ito Yasuhiko, Takahashi Hiroshi, Ishii Hideki, Kasuga Hirotake, Mizuno Masashi, Suzuki Yasuhiro, Yuzawa Yukio, Maruyama Shoichi, Murohara Toyoaki, Imai Enyu, Matsuo Seiichi

AMERICAN JOURNAL OF NEPHROLOGY Vol. 36 ( 2 ) page： 136 - 143 2012

腹膜組織における補体活性化の観点からみた、現在の透析液の問題

水野正司, 伊藤恭彦, 鈴木康弘, 松尾清一

腎と透析 2012 （腎と透析別冊） Vol. 73 page： 109-110 2012

平松英樹, 林祐樹, 水野正司, 鈴木康弘, 戸田晋, 伊藤功, 丸山彰一, 伊藤恭彦, 松尾清一

日本透析医学会会誌 Vol. 45 page： 247-253 2012

各論２腹膜透析ガイドライン, 3. 腹膜炎管理 ISPDガイドラインを本邦の実地臨床にいかに活用するか？本邦のガイドラインをいかにすべきか？ Invited

伊藤恭彦, 水野正司, 鈴木康弘, 清祐実, 平松英樹, 松尾清一

臨床透析 Vol. 28 page： 856-864 2012

A case of perforative peritonitis caused by a piece of bamboo in a patient on peritoneal dialysis Reviewed International journal

SUZUKI Yasuhiro, MIZUNO Masashi, NAKASHIMA Ryoko, HIRAMATSU Hideki, TODA Susumu, SATO Waichi, TSUBOI Naotake, ITO Isao, MARUYAMA Shoichi, IMAI Enyu, MATSUO Seiichi, ITO Yasuhiko

Vol. 15 ( 6 ) page： 962 - 965 2011.12

A case of perforative peritonitis caused by a piece of bamboo in a patient on peritoneal dialysis Reviewed International journal

Yasuhiro Suzuki, Masashi Mizuno, Ryoko Nakashima, Hideki Hiramatsu, Susumu Toda, Waichi Sato, Naotake Tsuboi, Isao Ito, Shoichi Maruyama, Enyu Imai, Seiichi Matsuo, Yasuhiko Ito

CLINICAL AND EXPERIMENTAL NEPHROLOGY Vol. 15 ( 6 ) page： 962 - 965 2011.12

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER

We report a case of peritonitis resulting from colon perforation caused by ingestion of a rare foreign body in a patient on peritoneal dialysis (PD). A 72-year-old woman on PD was hospitalized with abdominal pain and cloudy PD fluid (PDF). Although conventional antibiotic therapy was started because of a diagnosis of infectious peritonitis, low-grade fever, abdominal pain and a high number of white blood cells in PDF persisted. On day 3, anaerobic bacteria were recognized on bacterial culture of PDF, suggesting a gastrointestinal etiology. During exploratory laparotomy, sigmoidal perforation by a piece of bamboo, probably resulting from ingestion of contaminated food, was found.

DOI： 10.1007/s10157-011-0529-7

Web of Science

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Peritonitis is still an important factor for withdrawal from peritoneal dialysis therapy in the Tokai area of Japan

MIZUNO Masashi, ITO Yasuhiko, TANAKA Akio, SUZUKI Yasuhiro, HIRAMATSU Hideki, WATANABE Midoriko, TSURUTA Yoshikazu, MATSUOKA Teppei, ITO Isao, TAMAI Hiroshi, KASUGA Hirotake, SHIMIZU Hideaki, KURATA Hisashi, INAGUMA Daijo, HIRAMATSU Takeyuki, HORIE Masanobu, NARUSE Tomohiko, MARUYAMA Shoichi, IMAI Enyu, YUZAWA Yukio, MATSUO Seiichi

Clinical and experimental nephrology Vol. 15 ( 5 ) page： 727 - 737 2011.10

Non-physiological osmolarity and pH in peritoneal dialysis fluid impair complement regulation in rat peritoneal mesothelial cells International coauthorship International journal

Mizuno, M; Mizuno, T; Ito, Y; Suzuki, Y; Kinashi, H; Noda, Y; Yamada, K; Okada, N; Morgan, BP; Matsuo, S

MOLECULAR IMMUNOLOGY Vol. 48 ( 14 ) page： 1690 - 1690 2011.8

Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients. Reviewed

Sawai A, Ito Y, Mizuno M, Suzuki Y, Toda S, Ito I, Hattori R, Matsukawa Y, Gotoh M, Takei Y, Yuzawa Y, Matsuo S

Vol. 26 ( 7 ) page： 2322-2332 2011.7

Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients Reviewed International journal Open Access

Sawai Akiho, Ito Yasuhiko, Mizuno Masashi, Suzuki Yasuhiro, Toda Susumu, Ito Isao, Hattori Ryohei, Matsukawa Yoshihisa, Gotoh Momokazu, Takei Yoshifumi, Yuzawa Yukio, Matsuo Seiichi

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 26 ( 7 ) page： 2322 - 2332 2011.7

Specific collaboration between rat membrane complement regulators Crry and CD59 protects peritoneum from damage by autologous complement activation Reviewed International coauthorship International journal

Tomohiro Mizuno, Masashi Mizuno, B. Paul Morgan, Yukihiro Noda, Kiyofumi Yamada, Noriko Okada, Yukio Yuzawa, Seiichi Matsuo, Yasuhiko Ito

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 26 ( 6 ) page： 1821 - 1830 2011.6

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：OXFORD UNIV PRESS

Background. The peritoneal cavity is isolated from the outside and is usually a sterile environment. Patients on peritoneal dialysis (PD) have PD fluid (PDF) infused into the peritoneal cavity. We previously showed that unregulated complement activation could contribute to the development of peritoneal inflammation in yeast peritonitis in PD therapy. In that situation, suppression of local complement activation is essential to protect the host from further injury. The membrane complement regulators (CRegs), Crry, CD55 and CD59, are expressed in the rat peritoneum, especially along the mesothelial cell layer.
Methods. We investigated CRegs' functional roles in the peritoneal cavity using blocking mAb against each CReg and complement activation in different PDFs.
Results. Blockade of any single CReg did not cause spontaneous peritoneal injury in rat. Combined blockade of Crry and CD59 induced focal peritoneal tissue injury and heavy accumulation of inflammatory cells with peritoneal edema at 24 h. Deposits of C3 and C5b-9 were found on the peritoneal surface after combined blocking of Crry and CD59. Systemic complement depletion by cobra venom factor abrogated these inflammatory changes. When combined blockade of Crry and CD59 was performed with PDF of different pH and glucose concentration in rats, the peritoneal injuries were enhanced with lower pH and higher glucose concentration. These results were confirmed by in vitro experiments using primary rat mesothelial cell culture.
Conclusions. Rat CRegs, Crry and CD59, specifically collaborate to control complement activation in rat peritoneum. During PD, impairment of CReg might contribute to the development of severe peritoneal inflammation.

DOI： 10.1093/ndt/gfq683

Web of Science

PubMed

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Lymphangiogenesis develop during tubulo-interstitial fibrosis via TGF-beta VEGF-C pathway in rat unilateral ureteral obstruction. Reviewed

Suzuki Y, Ito Y, Mizuno M, Sawai A, Kinashi H, Noda Y, Kato H, Shimizu H, Fujita Y, Matsui K, Imai E, Yuzawa Y, Matsuo S, Takei Y.

Kidney Int Vol. ??? in press page： ???????? 2011

Asymptomatic diverticulosis identified by computed tomography is not a risk factor for enteric peritonitis. Reviewed

Toda S, Ito Y, Mizuno M, Suzuki Y, Ito I, Hiramatsu H, Ozaki T, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S.

Nephrol Dial Transplant Vol. ?? page： ?????? in press 2011

A case of perforative peritonitis by a piece of bamboo in a patient on peritoneal dialysis. Reviewed

Suzuki Y., Mizuno M., Nakashima R., Hiramatsu H., Toda S., Sato W., Tsuboi N., Ito I., Maruyama S., Imai E., Matsuo S., Ito Y.

Clin Exp Nephrol Vol. 15 page： 962-965 2011

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Papers - MIZUNO, Masashi