Faculty Profiles - MIZUNO, Masashi

Papers - MIZUNO, Masashi

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基礎カンファレンス腹膜線維化に関する基礎研究の進歩、腹膜線維症・機能不全と成長因子

伊藤恭彦, 水野正司, 松尾清一

腎と透析2010 Vol. Vol.69 page： 128 - 131 2010

名大腎不全システム研究会レジストリによる東海地区13施設の3年間(2005～2007)解析から得た、現在の腹膜透析療法の傾向と問題点 Reviewed

水野正司, 伊藤恭彦, 松尾清一

腎と透析2010 Vol. Vol.69 page： 638 - 640 2010

Acute Kidney Injury Presenting a Feature of Leukemic Infiltration during Therapy for Chronic Myelogenous Leukemia International journal

Yukio Yuzawa, Waichi Sato, Tomohiro Masuda, Yuzuru Hamada, Miho Tatematsu, Yoshinari Yasuda, Takenori Ozaki, Isao Ito, Masashi Mizuno, Shoichi Maruyama, Yasuhiko Ito, Seiichi Matsuo

INTERNAL MEDICINE Vol. 49 ( 12 ) page： 1139 - 1142 2010

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN SOC INTERNAL MEDICINE

Chronic myelogenous leukemia (CML) is a myeloproliferative disease that originates in abnormal pluripotent bone marrow stem cells and it is consistently associated with the Philadelphia chromosome and/or BCR/ABL fusion gene. Renal infiltration of leukemic cells is relatively rare in CML and is associated with renal impairment. We describe a patient who developed acute renal failure by tubulointerstitial nephropathy during treatment with imatinib mesylate for CML. The acute kidney injury was subsequently found to be due to direct leukemic infiltration. Treatment with hydroxycarbamide and prednisolone resulted in stabilization of the renal function for approximately 4 months. Leukemic infiltration into the kidney should always be considered when a patient with CML presents with renal impairment, regardless of the clinical stage, as the renal failure often responds well to chemotherapy.

DOI： 10.2169/internalmedicine.48.2747

名大腎不全システム研究会レジストリによる東海地区13施設の３年間（2005～2007）解析から得た、現在の腹膜透析療法の傾向と問題点

水野正司, 伊藤恭彦, 田中章郎, 平松英樹, 渡辺緑子, 稲熊大城, 戸田晋, 檀原敦, 玉井宏史, 倉田久嗣, 春日弘毅, 志水英明, 松岡哲平, 鶴田吉和, 堀江正宣, 成瀬友彦, 平松武幸, 伊藤功, 丸山彰一, 湯澤由紀夫, 松尾清一

腎と透析 2010 （腎と透析別冊） Vol. 69 page： 638-640 2010

基礎カンファレンス腹膜線維化に関する基礎研究の進歩, 腹膜線維症・機能不全と成長因子特にTGF-β/CTGF/VEGFからの検討

伊藤恭彦, 水野正司, 水谷真, 西村勇人, 鈴木康弘, 澤井晶穂, 鬼無洋, 湯澤由紀夫, 松尾清一

腎と透析 2010（腎と透析別冊） Vol. 69 page： 128-131 2010

Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice Reviewed International journal

Kei Kurata, Shoichi Maruyama, Sawako Kato, Waichi Sato, Jun-ichiro Yamamoto, Takenori Ozaki, Atsumi Nitta, Toshitaka Nabeshima, Yoshiki Morita, Masashi Mizuno, Yasuhiko Ito, Yukio Yuzawa, Seiichi Matsuo

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY Vol. 297 ( 6 ) page： F1510 - 7 2009.12

Language：English Publishing type：Research paper (scientific journal) Publisher：AMER PHYSIOLOGICAL SOC

Kurata K, Maruyama S, Kato S, Sato W, Yamamoto J, Ozaki T, Nitta A, Nabeshima T, Morita Y, Mizuno M, Ito Y, Yuzawa Y, Matsuo S. Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice. Am J Physiol Renal Physiol 297: F1510-F1517, 2009. doi:10.1152/ajprenal.90330.2008.-Peritoneal fibrosis (PF) is an important complication of peritoneal dialysis therapy. The present study was performed to examine the mechanisms of PF in view of the plasminogen activator (PA)/plasmin/matrix metalloproteinase (MMP) cascade. PF was induced in tissue-type PA (tPA) deficient mice and wild-type mice by intraperitoneal injection of chlorhexidine gluconate. Mice were killed on day 21, and tissue samples were taken. Histopathological studies were performed. Plasmin activity, gelatinases activity, and the levels of tPA, transforming growth factor-beta 1 (TGF-(sic)1), and MMP-2 mRNA were determined. Protein levels of MMP- 3, tissue inhibitor of metalloproteinases (TIMP)-1, -2, and -3, phospho-Smad3, membrane-type 1 (MT1)-MMP, and MT3-MMP were also studied. On day 21, tPA +/+ mice showed severe PF, whereas tPA -/- mice showed milder change. Submesothelial basement membranes were dissolved in tPA +/+ mice while they were relatively preserved in tPA -/- mice. The levels of macrophage infiltration, staining for alpha-smooth muscle actin (alpha-SMA) and collagen type III, and vascular density were all significantly lower in tPA -/- mice than in tPA +/+ mice. The levels of plasmin activity, pro- and active MMP- 2, mRNA expression of tPA and TGF-beta 1, and phospho-Smad3 protein were also lower in tPA -/- mice. No difference was observed between the two groups concerning the protein levels of MMP-3, TIMP-1, TIMP-2, TIMP-3, MT1-MMP, or MT3-MMP. These results indicate that the presence of tPA enhances inflammation, angiogenesis, and fibrogenesis in the peritoneum of the PF model mice. Activation of the PA/plasmin/MMP cascade may play a pivotal role in the pathogenesis of PF.

DOI： 10.1152/ajprenal.90330.2008

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Specific collaboration between rat membrane complement regulators, Crry and CD59, protects peritoneum from damage by autologous complement activation in peritoneal dialysate fluid

Tomohiro Mizuno, Masashi Mizuno, B. Paul Morgan, Noriko Okada, Yukihiro Noda, Yukio Yuzawa, Seiichi Matsuo, Yasuhiko Ito

MOLECULAR IMMUNOLOGY Vol. 46 ( 14 ) page： 2859 - 2860 2009.9

Lymphatic vessels develop during tubulointerstitial fibrosis Reviewed International journal Open Access

Sakamoto Izumi, Ito Yasuhiko, Mizuno Masashi, Suzuki Yasuhiro, Sawai Akiho, Tanaka Akio, Maruyama Shoichi, Takei Yoshifumi, Yuzawa Yukio, Matsuo Seiichi

KIDNEY INTERNATIONAL Vol. 75 ( 8 ) page： 828 - 838 2009.4

Lymphatic vessels develop during tubulointerstitial fibrosis. Reviewed

Sakamoto I, Ito Y, Mizuno M, Suzuki Y, Sawai A, Tanaka A, Maruyama S, Takei Y, Yuzawa Y, Matsuo S.

Kidney Int Vol. 75 page： 828-838 2009

Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice. Reviewed

Kurata K, Maruyama S, Kato S, Sato W, Yamamoto J, Ozaki T, Nitta A, Nabeshima T, Morita Y, Mizuno M, Ito Y, Yuzawa Y, Matsuo S.

Am J Physiol Renal Physiol Vol. 297 ( F1510-1517 ) 2009

The role of membrane complement regulators in the normal peritoneal cavity

Tomohiro Mizuno, Masashi Mizuno, Yasuhiko Ito, Seiiti Matsuo, Yukihiro Noda

JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 109 page： 59P - 59P 2009

Zymosan, but not LPS, triggers severe and progressive peritoneal injury accompanied by complement activation in a rat peritonitis model initiated by mechanical scraping Reviewed International coauthorship International journal

Masashi Mizuno, Yasuhiko Ito, Tomohiro Mizuno, Claire L. Harris, B. Paul Morgan, Natalie Hepburn, Hayato Nishimura, Seiichi Matsuo

MOLECULAR IMMUNOLOGY Vol. 45 ( 16 ) page： 4153 - 4154 2008.10

Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model Reviewed International journal

Nishimura Hayato, Ito Yasuhiko, Mizuno Masashi, Tanaka Akio, Morita Yoshiki, Maruyama Shoichi, Yuzawa Yukio, Matsuo Seiichi

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY Vol. 294 ( 5 ) page： F1084 - F1093 2008.5

The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility. Reviewed

Donev RM., Sivasankar B., Mizuno M., Morgan BP.

Mol. Immunol. Vol. 45 page： 534-542 2008.1

The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility (Retracted article. See vol. 58, pg. 150, 2014) Reviewed International coauthorship International journal

Rossen M. Donev, Baalasubrarnanian Sivasankar, Masashi Mizuno, B. Paul Morgan

MOLECULAR IMMUNOLOGY Vol. 45 ( 2 ) page： 534 - 542 2008.1

Language：English Publishing type：Research paper (scientific journal) Publisher：PERGAMON-ELSEVIER SCIENCE LTD

\In mouse, genes encoding complement regulators CD55 and CD59 have been duplicated. The first described form of CD59, CD59a, is broadly distributed in mouse tissues, while the later identified CD59b was originally described as testis specific. Subsequent studies have been contradictory, some reporting widespread and abundant expression of CD59b. Resolution of the distribution patterns of the CD59 isoforms is important for interpretation of disease studies utilising CD59 knockout mice. Here we have performed a comprehensive distribution study of the CD59 isoforms at the mRNA and protein levels. These data confirm that expression of CD59b is essentially restricted to adult testis; trace expression in other tissues is a consequence of contamination with blood cells, shown previously to express CD59b at low level. In testis, onset of expression of CD59b coincided with puberty and was predominant on the spermatozoal acrosome. Ligation of CD59b, but not CD59a, markedly reduced spermatozoal motility, suggesting a specific role in reproductive function. (c) 2007 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.molimm.2007.05.011

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Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model. Reviewed

Nishimura H, Ito Y, Mizuno M, Tanaka A, Morita Y, Maruyama S, Yuzawa Y, Matsuo S.

Am J Physiol Renal Physiol Vol. 294 page： F1084-F1093 2008