Faculty Profiles - MIZUNO, Masashi

Papers - MIZUNO, Masashi

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Specific collaboration between rat membrane complement regulators, Crry and CD59, protects peritoneum from damage by autologous complement activation in peritoneal dialysate fluid

Tomohiro Mizuno, Masashi Mizuno, B. Paul Morgan, Noriko Okada, Yukihiro Noda, Yukio Yuzawa, Seiichi Matsuo, Yasuhiko Ito

MOLECULAR IMMUNOLOGY Vol. 46 ( 14 ) page： 2859 - 2860 2009.9

Lymphatic vessels develop during tubulointerstitial fibrosis Reviewed International journal

Sakamoto Izumi, Ito Yasuhiko, Mizuno Masashi, Suzuki Yasuhiro, Sawai Akiho, Tanaka Akio, Maruyama Shoichi, Takei Yoshifumi, Yuzawa Yukio, Matsuo Seiichi

KIDNEY INTERNATIONAL Vol. 75 ( 8 ) page： 828 - 838 2009.4

Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice. Reviewed

Kurata K, Maruyama S, Kato S, Sato W, Yamamoto J, Ozaki T, Nitta A, Nabeshima T, Morita Y, Mizuno M, Ito Y, Yuzawa Y, Matsuo S.

Am J Physiol Renal Physiol Vol. 297 ( F1510-1517 ) 2009

Lymphatic vessels develop during tubulointerstitial fibrosis. Reviewed

Sakamoto I, Ito Y, Mizuno M, Suzuki Y, Sawai A, Tanaka A, Maruyama S, Takei Y, Yuzawa Y, Matsuo S.

Kidney Int Vol. 75 page： 828-838 2009

The role of membrane complement regulators in the normal peritoneal cavity

Tomohiro Mizuno, Masashi Mizuno, Yasuhiko Ito, Seiiti Matsuo, Yukihiro Noda

JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 109 page： 59P - 59P 2009

Zymosan, but not LPS, triggers severe and progressive peritoneal injury accompanied by complement activation in a rat peritonitis model initiated by mechanical scraping Reviewed International coauthorship International journal

Masashi Mizuno, Yasuhiko Ito, Tomohiro Mizuno, Claire L. Harris, B. Paul Morgan, Natalie Hepburn, Hayato Nishimura, Seiichi Matsuo

MOLECULAR IMMUNOLOGY Vol. 45 ( 16 ) page： 4153 - 4154 2008.10

Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model Reviewed International journal

Nishimura Hayato, Ito Yasuhiko, Mizuno Masashi, Tanaka Akio, Morita Yoshiki, Maruyama Shoichi, Yuzawa Yukio, Matsuo Seiichi

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY Vol. 294 ( 5 ) page： F1084 - F1093 2008.5

The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility. Reviewed

Donev RM., Sivasankar B., Mizuno M., Morgan BP.

Mol. Immunol. Vol. 45 page： 534-542 2008.1

The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility (Retracted article. See vol. 58, pg. 150, 2014) Reviewed International coauthorship International journal

Rossen M. Donev, Baalasubrarnanian Sivasankar, Masashi Mizuno, B. Paul Morgan

MOLECULAR IMMUNOLOGY Vol. 45 ( 2 ) page： 534 - 542 2008.1

Language：English Publishing type：Research paper (scientific journal) Publisher：PERGAMON-ELSEVIER SCIENCE LTD

\In mouse, genes encoding complement regulators CD55 and CD59 have been duplicated. The first described form of CD59, CD59a, is broadly distributed in mouse tissues, while the later identified CD59b was originally described as testis specific. Subsequent studies have been contradictory, some reporting widespread and abundant expression of CD59b. Resolution of the distribution patterns of the CD59 isoforms is important for interpretation of disease studies utilising CD59 knockout mice. Here we have performed a comprehensive distribution study of the CD59 isoforms at the mRNA and protein levels. These data confirm that expression of CD59b is essentially restricted to adult testis; trace expression in other tissues is a consequence of contamination with blood cells, shown previously to express CD59b at low level. In testis, onset of expression of CD59b coincided with puberty and was predominant on the spermatozoal acrosome. Ligation of CD59b, but not CD59a, markedly reduced spermatozoal motility, suggesting a specific role in reproductive function. (c) 2007 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.molimm.2007.05.011

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Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model. Reviewed

Nishimura H, Ito Y, Mizuno M, Tanaka A, Morita Y, Maruyama S, Yuzawa Y, Matsuo S.

Am J Physiol Renal Physiol Vol. 294 page： F1084-F1093 2008

『特集　アシドーシスとアルカローシス』代謝性酸塩基平衡異常における治療の基本とその方法 Invited

伊藤恭彦、水野正司

薬局 Vol. 59 page： 42-47 2008

本邦のCAPD療法の現況　–　CAPD療法に対する取り組み　大学・教育病院の役割 Invited

伊藤恭彦、水野正司、丸山彰一、湯澤　由紀夫、松尾清一

臨床透析 Vol. 24 page： 205-210 2008

Complement C3a receptor was highly found in the glomeruli of inflamed human lupus nephritis International coauthorship International journal

Mizuno, M; Blanchin, S; Gasque, P; Nishikawa, K; Matsuo, S

MOLECULAR IMMUNOLOGY Vol. 44 ( 16 ) page： 3953 - 3953 2007.9

CD59b is abundantly expressed only in testis and plays a role in acrosome activation and spermatozoal motility Reviewed International coauthorship International journal

Donev, RM; Sivasankar, B; Mizuno, M; Morgan, BP

MOLECULAR IMMUNOLOGY Vol. 44 ( 16 ) page： 3956 - 3956 2007.9

A protein toxin from the sea anemone Phyllodiscus semoni targets the kidney and causes a renal injury resembling haemolytic uremic syndrome. Reviewed

Mizuno M., Nozaki M., Morine N., Suzuki N., Nishikawa K., Morgan BP., Matsuo S.

Am. J. Pathol. Vol. 171 page： 402-414 2007.8

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

Envenomation by the sea anemone Phyllodiscus semoni causes fulminant dermatitis and, rarely, acute renal failure in humans. Here, we investigated whether the venom extracted from the nematocysts (PsTX-T) was nephrotoxic when administered intravenously in rats and whether PsTX-T induced activation of the complement system. Although small dose of PsTX-T induced acute tubular necrosis in rats resembling pathology seen in patients, kidneys displayed glomerular injury with glomerular endothelial damage, thrombus formation, mesangiolysis, and partial rupture of glomerular basement membrane, accompanied by severe tubular necrosis at 24 hours after administration of 0.03 mg of PsTX-T per animal, similar to the glomerular findings typical of severe hemolytic uremic syndrome. The early stage injury was accompanied by specific PsTX-T binding, massive complement C3b, and membrane attack complex deposition in glomeruli in the regions of injury and decreased glomerular expression of complement regulators. A pathogenic role for complement was confirmed by demonstrating that systemic complement inhibition reduced renal injury. The isolated nephrotoxic component, a 115-kd protein toxin (PsTX-115), was shown to cause identical renal pathology. The demonstration that PsTX-T and PsTX-115 were highly nephrotoxic acting via induction of complement activation suggests that inhibition of complement might be used to prevent acute renal damage following envenomation by P. semoni.

CD55 in rat male reproductive tissue: Differential expression in testis and expression of a unique truncated isoform on spermatozoa International coauthorship International journal

Mizuno, M; Donev, RM; Harris, CL; Morgan, BP

MOLECULAR IMMUNOLOGY Vol. 44 ( 7 ) page： 1613 - 1622 2007.3

Immunisation with CD46 generates a strong autoantibody response targeting the spermatozoal acrosome in rat

Mizuno, M; Harris, CL; Morgan, BP

MOLECULAR IMMUNOLOGY Vol. 44 ( 1-3 ) page： 216 - 216 2007.1

High levels of complement C3a receptor in the glomeruli of inflamed human lupus nephritis. Reviewed

Mizuno M., Blanchin S., Gasque P., Nishikawa K., Matsuo S.

Am. J. Kidney Dis. Vol. 49 page： 598-606 2007

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Taking into consideration the key role of the complement system in renal diseases, we investigated molecular and cellular properties of the human complement C3a receptor (C3aR) in vitro and in situ, looking at its expression in several human renal pathological states. METHODS: Several antibodies were generated and used for immunohistochemistry and Western blot analyses to address C3aR expression and its regulation in vitro on cell lines of myeloid cells and nonmyeloid cell lineages. Furthermore, C3aR distribution was investigated in control nephrectomized kidneys and 116 biopsy specimens from patients with renal diseases, including lupus nephritis (lupus-N). RESULTS: C3aR is a highly N-glycosylated protein with an apparent molecular mass of 65 to 95 kd expressed by myeloid and endothelial cells. C3aR is particularly upregulated in response to interferon gamma treatment, but was unaffected by the other inflammatory cytokines, such as tumor necrosis factor alpha and transforming growth factor beta. In normal human kidney, C3aR staining was not observed. However, glomerular C3aR staining was detected in 42.9% of lupus-N specimens in association with immunoglobulin G immune-complex depositions. Staining intensity correlated with disease severity. C3aR was found in the endothelial area of 81.3% of samples classified as World Health Organization class IV with active lesions. Conversely, C3aR was not detected by means of immunohistochemistry in kidneys from patients with other renal diseases. CONCLUSION: Our data indicate that C3aR expression is tightly regulated and altered in certain disease conditions. C3aR may be used as a unique biomarker of diagnosis and disease activity in patients with lupus-N.

よく使う利尿薬について習熟する　スピロノラクトン Invited

水野正司、伊藤恭彦

Medicina Vol. 44 page： 359-342 2007

Immunization with autologous CD46 in rats generates a strong autoantibody response that targets spermatozoa. Reviewed

Mizuno M., Harris CL., Morgan BP.

J. Reprod. Immunol. Vol. 73 page： 135-147 2007

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