Faculty Profiles - MIZUNO, Masashi

Papers - MIZUNO, Masashi

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Extracellular histones decrease the expression of membrane complement regulators Reviewed International journal

Mizuno Tomohiro, Nagano Fumihiko, Mizuno Masashi, Iwata Ayumi, Takahashi Kazuo, Tsuboi Naotake, Maruyama Shoichi, Nagamatsu Tadashi, Imai Masaki

MOLECULAR IMMUNOLOGY Vol. 102 page： 189-189 2018.10

Peritoneal expression of membrane complement regulators in peritoneal dialysis patients with fungal peritonitis

Fukui Sosuke, Suzuki Yasuhiro, Tawada Mitsuhiro, Matsukawa Yoshihisa, Imai Masaki, Maruyama Shoichi, Ito Yasuhiko, Mizuno Masashi

MOLECULAR IMMUNOLOGY Vol. 102 page： 152 - 152 2018.10

Comprehensive analysis of complement proteins and genes in thrombotic microangiopathy in Japan

Hidaka, Y; Inoue, N; Ohtani, K; Ohtsuka, Y; Sawai, T; Miyata, T; Ohsawa, I; Okada, H; Kinoshita, T; Sekine, H; Tsukamoto, H; Nakao, M; Mizuno, M; Murakami, Y; Horiuchi, T; Wakamiya, N

MOLECULAR IMMUNOLOGY Vol. 102 page： 163 - 163 2018.10

SODIUM RESTRICTED DIET DURING CONSERVATIVE THERAPY IN PATIENTS WITH END-STAGE RENAL DISEASES (ESRD) MAY RESCUE RESIDUAL RENAL FUNCTION (RRF) FOR THE FIRST YEAR AFTER STARTING PERITONEAL DIALYSIS (PD)

Hiramatsu Tetsuaki, Mizuno Masashi, Nomori Sumiyo, Sakata Fumiko, Suzuki Yasuhiro, Maruyama Shoichi, Yasuhiko Ito, Noguchi Satoshi

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 33 page： . 2018.5

高齢腹膜透析患者の地域連携における現状と課題

伊藤恭彦, 水野正司, 鈴木康弘, 杉山斉, 深水圭, 猪阪善隆

医工学治療 Vol. 30 ( Suppl. ) page： 161 - 161 2018.3

TGF-beta 1-VEGF-A pathway induces neoangiogenesis with peritoneal fibrosis in patients undergoing peritoneal dialysis Reviewed International journal

Kariya Tetsuyoshi, Nishimura Hayato, Mizuno Masashi, Suzuki Yasuhiro, Matsukawa Yoshihisa, Sakata Fumiko, Maruyama Shoichi, Takei Yoshifumi, Ito Yasuhiko

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY Vol. 314 ( 2 ) page： F167 - F180 2018.2

Current Status of Peritoneal Dialysis in Japan. Reviewed International coauthorship International journal

Ito Y, Tawada M, Tine S, Mizuno M, Suzuki Y, Katsuno T

Contributions to nephrology Vol. 196 page： 123 - 128 2018

Peritoneal eosinophils increase during induction of peritoneal dialysis and may be related to production of C3a in peritoneal dialysate

Mizuno Masashi, Shigemoto Emi, Kobayashi Kazuma, Iguchi Daiki, Sakata Fumiko, Suzuki Yasuhiro, Maruyama Shoichi, Ito Yasuhiko

MOLECULAR IMMUNOLOGY Vol. 89 page： 193-193 2017.9

Establishment of a complement examination system for complement-related diseases by the Japanese Association for Complement Research (JACR)

Yoshihiko Hidaka, Norimitsu Inoue, Yasufumi Ohtsuka, Toshihiro Sawai, Toshiyuki Miyata, Isao Osawa, Katsuki Ohtani, Hidechika Okada, Taroh Kinoshita, Hideharu Sekine, Hiroshi Tsukamoto, Miki Nakao, Masashi Mizuno, Yoshiko Murakami, Takahiko Horiuchi, Nobutaka Wakamiya

MOLECULAR IMMUNOLOGY Vol. 89 page： 192 - 192 2017.9

Hexamerization-enhanced CD20 antibody mediates complement-dependent cytotoxicity in serum genetically deficient in C9 Reviewed International coauthorship International journal Open Access

Ronald P. Taylor, Margaret A. Lindorfer, Erika M. Cook, Frank J. Beurskens, Janine Schuurman, Paul W. H. I. Parren, Clive S. Zent, Karl R. VanDerMeid, Richard Burack, Masashi Mizuno, B. Paul Morgan

CLINICAL IMMUNOLOGY Vol. 181 page： 24 - 28 2017.8

Language：English Publishing type：Research paper (scientific journal) Publisher：ACADEMIC PRESS INC ELSEVIER SCIENCE

We examined complement-dependent cytotoxicity (CDC) by hexamer formation-enhanced CD20 mAb Hx-7D8 of patient-derived chronic lymphocytic leukemia (CLL) cells that are relatively resistant to CDC. CDC was analyzed in normal human serum (NHS) and serum from an individual genetically deficient for C9. Hx-7D8 was able to kill up to 80% of CLL cells in complete absence of C9. We conclude that the narrow C5b-8 pores formed without C9 are sufficient for CDC due to efficient antibody-mediated hexamer formation. In the absence of C9, we observed transient intracellular increases of Ca2+ during CDC (as assessed with FLUO-4) that were extended in time. This suggests that small C5b-8 pores allow Ca2+ to enter the cell, while dissipation of the fluorescent signal accompanying cell disintegration is delayed. The Ca2+ signal is retained concomitantly with TOPRO-3 (viability dye) staining, thereby confirming that Ca2+ influx represents the most proximate mediator of cell death by CDC. (C) 2017 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.clim.2017.05.016

Apoptosis inhibitor of macrophage ameliorates fungus-induced peritoneal injury model in mice Reviewed International journal Open Access

Takako Tomita, Satoko Arai, Kento Kitada, Masashi Mizuno, Yasuhiro Suzuki, Fumiko Sakata, Daisuke Nakano, Emiri Hiramoto, Yoshifumi Takei, Shoichi Maruyama, Akira Nishiyama, Seiichi Matsuo, Toru Miyazaki, Yasuhiko Ito

SCIENTIFIC REPORTS Vol. 7 ( 1 ) page： 6450 2017.7

Language：English Publishing type：Research paper (scientific journal) Publisher：NATURE PUBLISHING GROUP

Fungal peritonitis in a patient on peritoneal dialysis (PD) is a refractory injury accompanied by severe inflammation, predisposing patients to a poor prognosis. Defective clearance of necrotic tissue interferes with amelioration of tissue injury and induces abnormal tissue remodeling. In the recent reports, apoptosis inhibitor of macrophage (AIM, also called CD5L) prevents obesity, hepatocellular carcinoma and acute kidney injury. Here, we investigated potential roles of AIM in prevention of progression of fungal peritonitis models. AIM(-/)-mice subjected to zymosan-induced peritonitis exhibited progressive inflammation and sustained peritoneal necrosis tissue on day 28 after the disease induction, whereas there was an improvement in AIM(+/+) mice. This appeared to be caused by deposition of AIM at the necrotic peritoneum in AIM(+/+) mice. In vitro, AIM enhanced the engulfment of necrotic debris by macrophages derived from zymosan-induced peritonitis, M1-and M2a-like bone marrow derived macrophages, as well as by mesothelial cells. In addition, administration of recombinant AIM dramatically ameliorated severe inflammation associated with necrosis in zymosan-induced peritonitis of AIM(-/)-mice. Our observations suggest that AIM appears to be involved in the repair process of zymosan-induced peritonitis, and thus, could be the basis of development of new therapeutic strategies for PD-related fungal peritonitis.

DOI： 10.1038/s41598-017-06824-6

Sodium chloride promotes tissue inflammation via osmotic stimuli in subtotal-nephrectomized mice Reviewed International coauthorship International journal

Fumiko Sakata, Yasuhiko Ito, Masashi Mizuno, Akiho Sawai, Yasuhiro Suzuki, Takako Tomita, Mitsuhiro Tawada, Akio Tanaka, Akiyoshi Hirayama, Akihiro Sagara, Takashi Wada, Shoichi Maruyama, Tomoyoshi Soga, Seiichi Matsuo, Enyu Imai, Yoshifumi Takei

LABORATORY INVESTIGATION Vol. 97 ( 4 ) page： 432 - 446 2017.4

Language：English Publishing type：Research paper (scientific journal) Publisher：NATURE PUBLISHING GROUP

Chronic inflammation, which is often associated with high all-cause and cardiovascular mortality, is prevalent in patients with renal failure; however, the precise mechanisms remain unclear. High-salt intake was reported to induce lymphangiogenesis and autoimmune diseases via osmotic stimuli with accumulation of sodium or chloride. In addition, sodium was recently reported to be stored in the extremities of dialysis patients. We studied the effects and mechanisms of high salt loading on tissue and systemic inflammation in subtotal-nephrectomized mice (5/6Nx) and in cultured cells. Macrophage infiltration in the peritoneal wall (P<0.001), heart (P<0.05) and para-aortic tissues (P<0.001) was significantly higher in 5/6Nx with salt loading (5/6Nx/NaCl) than in 5/6Nx without salt loading (5/6Nx/Water); however, there were no significant differences in blood pressure and renal function between the groups. Tissue interleukin-6, monocyte chemotactic protein-1 (MCP-1), serum- and glucocorticoid-inducible kinase 1 (Sgk1) and tonicity-responsive enhancer binding protein (TonEBP) mRNA were significantly elevated in the peritoneal wall and heart with 5/6Nx/NaCl when compared with 5/6Nx/Water. Sodium was stored in the abdominal wall, exerting high-osmotic conditions. Reversal of salt loading reduced macrophage infiltration associated with decreased TonEBP in 5/6Nx/NaCl. Macrophage infiltration associated with fibrosis induced by salt loading was decreased in the 5/6Nx/NaCl/CC chemokine receptor 2 (CCR2, receptor of MCP-1)-deficient mice when compared with 5/6Nx/NaCl/Wild mice, suggesting that CCR2 is required for macrophage infiltration in 5/6Nx with NaCl loading. In cultured mesothelial cells and cardiomyocytes, culture media with high NaCl concentration induced MCP-1, Sgk1 and TonEBP mRNA, all of which were suppressed by TonEBP siRNA, indicating that both MCP-1 and Sgk1 are downstream of TonEBP. Our study indicates that high NaCl intake induces MCP-1 expression leading to macrophage infiltration via the TonEBP-MCP-1 pathway in 5/6Nx/NaCl mice, and that TonEBP has a central role in inflammation in patients with renal failure taking high salt.

DOI： 10.1038/labinvest.2017.4

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Tetracycline Reduces Kidney Damage Induced by <i>Loxosceles</i> Spider Venom Reviewed International coauthorship International journal

Okamoto, CK; Van den Berg, CW; Masashi, M; Gonçalves-de-Andrade, RM; Tambourgi, DV

TOXINS Vol. 9 ( 3 ) 2017.3

Complement component 5 promotes lethal thrombosis International journal

Mizuno Tomohiro, Yoshioka Kengo, Mizuno Masashi, Shimizu Mie, Nagano Fumihiko, Okuda Tomoyuki, Tsuboi Naotake, Maruyama Shoichi, Nagamatsu Tadashi, Imai Masaki

SCIENTIFIC REPORTS Vol. 7 page： 42714 2017.2

PDのエビデンス

多和田光洋, 鈴木康弘, 水野正司, 伊藤恭彦

日本透析医学会雑誌 Vol. 50 ( 11 ) page： 685 - 691 2017

Therapeutic effects of a C5a antagonist, AcPepA, for severe peritoneal injuries associated with fungal infection in a rat model

Masashi Mizuno, Daiki Iguchi, Emi Shigemoto, Kazuma Kobayashi, Fumiko Sakata, Yasuhiro Suzuki, Alan Okada, Hidechika Okada, Seiichi Matsuo, Yasuhiko Ito

IMMUNOBIOLOGY Vol. 221 ( 10 ) page： 1212 - 1212 2016.10

C5 promotes histone-induced lethal thromboembolism Reviewed

Tomohiro Mizuno, Kengo Yoshioka, Masashi Mizuno, Naotake Tsuboi, Shoichi Maruyama, Tadashi Nagamatsu, Masaki Imai

IMMUNOBIOLOGY Vol. 221 ( 10 ) page： 1140 - 1141 2016.10

Complement promote releasing transglutaminase 2 from cytoplasm Reviewed International journal

Hara Kaori, Mizuno Tomohiro, Takahashi Kazuo, Mizuno Masashi, Kato Akihiro, Onouchi Takanori, Tsutsumi Yutaka, Tatsukawa Hideki, Nagamatsu Tadashi, Hitomi Kiyotaka, Yuzawa Yukio

IMMUNOBIOLOGY Vol. 221 ( 10 ) page： 1142 - 1142 2016.10

TGF-beta-VEGF-A PATHWAY INDUCES NEOANGIOGENESIS IN PERITONEAL FIBROSIS OF PERITONEAL DIALYSIS

Tetsuyoshi Kariya, Yasuhiko Ito, Masashi Mizuno, Yasuhiro Suzuki, Fumiko Sakata, Takeshi Terabayashi, Takako Ishii, Mitsuhiro Tawada, Daiki Iguchi, Shoichi Maruyama, Seiichi Matsuo

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 31 page： 35 - 35 2016.5

APOPTOSIS INHIBITOR OF MACROPHAGE PROTEIN AMELIORATES FUNGUS-INDUCED PERITONEAL INJURY IN MICE BY UPREGULATION OF CLEARANCE OF NECROTIC DEBRIS

Takako Tomita, Yasuhiko Ito, Kento Kitada, Masashi Mizuno, Yasuhiro Suzuki, Fumiko Sakata, Daisuke Nakano, Shoichi Maruyama, Satoko Arai, Toru Miyazaki, Akira Nishiyama, Seiichi Matsuo

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 31 page： 1503 - 1503 2016.5

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Papers - MIZUNO, Masashi