Faculty Profiles - MIZUNO, Masashi

遺伝性血管性浮腫(Hereditary angioedema:HAE)診療ガイドライン改訂2019年版 Reviewed

堀内孝彦, 大澤勲, 今井優樹, 大谷克城, 関根英治, 塚本浩, 中尾実樹, 西村純一, 水野正司, 村上良子, 山本哲郎, 木下タロウ, 大井洋之, 井上徳光, 若宮伸隆, 野々山恵章, 一般社団法人日本補体学会, 厚生労働省難治性疾患等政策研究事業「原発性免疫不全症候群の診断基準・重症度分類および診療ガイドラインの確立に関する研究」研究班

補体 Vol. 57 ( 1 ) page： 3 - 22 2020.12

補体活性異常とC3腎症 Invited Reviewed

水野正司

日本小児腎臓病学会雑誌 Vol. 33 ( 1Suppl. ) page： 51 - 51 2020.12

ANALYSIS OF FREQUENCY AND KINDS OF ALARM HISTORIES OF HOME PD SYSTEM KAGUYA DURING THE INTRODUCTION: PERIOD IN A SINGLE CENTRE

Hiramatsu Tetsuaki, Mizuno Masasi, Suzuki Yasuhiro, Nomori Sumiyo, Suzuki Masafumi, Shiga Yoshiko, Sato Yuka, Nakamura Tomohiro, Ishimoto Takuji, Kosugi Tomoki, Maruyama Shoichi, Koyama Tomio

NEPHROLOGY Vol. 25 page： 77 - 78 2020.10

CASES OF ACUTE APPENDICITIS IN PATIENTS ON PERITONEAL DIALYSIS (PD) IN A SINGLE CENTRE DURING 15 YEARS

Mizuno, M; Suzuki, Y; Kojima, H; Sato, Y; Kinashi, H; Katsuno, T; Maruyama, S; Ito, Y

NEPHROLOGY Vol. 25 page： 82 - 82 2020.10

The effectiveness and safety of computed tomographic peritoneography and video-assisted thoracic surgery for hydrothorax in peritoneal dialysis patients: A retrospective cohort study in Japan. Reviewed International coauthorship International journal

Naoya Matsuoka, Makoto Yamaguchi, Akimasa Asai, Keisuke Kamiya, Hiroshi Kinashi, Takayuki Katsuno, Takaaki Kobayashi, Hirofumi Tamai, Takatoshi Morinaga, Takaaki Obayashi, Kichio Nakabayashi, Shigehisa Koide, Michimasa Nakanishi, Katsushi Koyama, Yasuhiro Suzuki, Takuji Ishimoto, Masashi Mizuno, Yasuhiko Ito

PloS one Vol. 15 ( 9 ) page： e0238602 2020.9

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

INTRODUCTION: Albeit uncommon, hydrothorax is an important complication of peritoneal dialysis (PD). Due to paucity of evidence for optimal treatment, this study aimed to evaluate the effectiveness and safety of computed tomographic (CT) peritoneography and surgical intervention involving video-assisted thoracic surgery (VATS) for hydrothorax in a retrospective cohort of patients who underwent PD in Japan. METHODS: Of the 982 patients who underwent PD from six centers in Japan between 2007 and 2019, 25 (2.5%) with diagnosed hydrothorax were enrolled in this study. PD withdrawal rates were compared between patients who underwent VATS for diaphragm repair (surgical group) and those who did not (non-surgical group) using the Kaplan-Meier method and log-rank test. RESULTS: The surgical and non-surgical groups comprised a total of 11 (44%) and 14 (56%) patients, respectively. Following hydrothorax diagnosis by thoracentesis and detection of penetrated sites on the diaphragm using CT peritoneography, VATS was performed at a median time of 31 days (interquartile range [IQR], 20-96 days). During follow-up (median, 26 months; IQR, 10-51 months), 9 (64.3%) and 2 (18.2%) patients in the non-surgical and surgical groups, respectively, withdrew from PD (P = 0.021). There were no surgery-related complications or hydrothorax relapse in the surgical group. CONCLUSIONS: This study demonstrated the effectiveness and safety of CT peritoneography and VATS for hydrothorax. This approach may be useful in hydrothorax cases to avoid early drop out of PD and continue PD in the long term. Further studies are warranted to confirm these results.

DOI： 10.1371/journal.pone.0238602

CD55 EXPRESSION CHANGES IN MESOTHELIAL CELLS OF PATIENTS ON PERITONEAL DIALYSIS (PD) THERAPY

補体からみたC3腎症とaHUS Invited

水野正司

日本小児腎臓病学会雑誌 Vol. 33 ( 1 ) page： 59 - 60 2020.4

Successful Introduction of Peritoneal Dialysis in an End-stage Renal Failure Patient with Idiopathic Aplastic Anemia Reviewed International journal

Suzuki Yasuhiro, Mizuno Masashi, Sakata Fumiko, Kojima Hiroshi, Sato Yuka, Kishimoto Mayuko, Suzuki Nobuaki, Kinashi Hiroshi, Saito Shoji, Katsuno Takayuki, Kosugi Tomoki, Maruyama Shoichi, Murata Makoto, Kiyoi Hitoshi, Ito Yasuhiko

Internal Medicine Vol. 59 ( 5 ) page： 683 - 687 2020

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine

A 45-year-old man with idiopathic aplastic anemia required renal replacement therapy (RRT) due to end-stage renal disease (ESRD). We succeeded in inserting the peritoneal dialysis (PD) catheter under cover of frequent red blood cell and platelet infusions because of severe pancytopenia. During the one-year period after starting PD using an ultraviolet-ray sterilization device, he developed severe leukopenia but no PD-related peritonitis or exit site/tunnel infection until he died of pneumonia. This case suggests that PD might be a suitable choice as RRT in ESRD patients with aplastic anemia, even in those with severe pancytopenia.

DOI： 10.2169/internalmedicine.3775-19

Dietary salt restriction during conservative therapy may prevent declines in residual renal function for the first year after starting peritoneal dialysis in patients with end-stage renal diseases Invited Reviewed International journal

Tetsuaki Hiramatsu, Masashi Mizuno, Yasuhiro Suzuki, Sumiyo Nomori, Yoshiko Shiga, Ting Sun, Takako Ishii, Hiroshi Kojima, Takayuki Katsuno, Tomohiro Nakamura, Tomoki Kosugi, Shoichi Maruyama, Tomio Koyama, Satoshi Noguchi, Yasuhiko Ito

Integrative Food, Nutrition and Metabolism Vol. 7 ( 1 ) 2020

Excessive salt intake increases peritoneal solute transport rate via local tonicity-responsive enhancer binding protein in subtotal nephrectomized mice. Reviewed International journal

Sun T, Sakata F, Ishii T, Tawada M, Suzuki Y, Kinashi H, Katsuno T, Takei Y, Maruyama S, Mizuno M, Ito Y

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Vol. 34 ( 12 ) page： 2031 - 2042 2019.12

Ozeki Toshikazu, Mizuno Masashi, Kobayashi Kazuma, Iguchi Daiki, Sei Yumi, Suzuki Yasuhiro, Kojima Hiroshi, Fukui Sosuke, Yamashita Ryoko, Kinashi Hiroshi, Imai Masaki, Maruyama Shoichi, Ito Yasuhiko

MOLECULAR IMMUNOLOGY Vol. 114 page： 422 - 422 2019.10

Connective tissue growth factor is correlated with peritoneal lymphangiogenesis. Reviewed International coauthorship International journal

Hiroshi Kinashi, Naohiro Toda, Ting Sun, Tri Q Nguyen, Yasuhiro Suzuki, Takayuki Katsuno, Hideki Yokoi, Jan Aten, Masashi Mizuno, Shoichi Maruyama, Motoko Yanagita, Roel Goldschmeding, Yasuhiko Ito

Scientific reports Vol. 9 ( 1 ) page： 12175 - 12175 2019.8

Language：English Publishing type：Research paper (scientific journal)

Lymphatic absorption in the peritoneal cavity may contribute to ultrafiltration failure in peritoneal dialysis (PD). Lymphatic vessels develop during PD-related peritoneal fibrosis. Connective tissue growth factor (CTGF, also called CCN2) is an important determinant of fibrotic tissue remodeling, but little is known about its possible involvement in lymphangiogenesis. In this study, we investigated the relationship between CTGF and peritoneal lymphangiogenesis. A positive correlation was observed between vascular endothelial growth factor-C (VEGF-C), a major lymphangiogenic growth factor, and the CTGF concentration in human PD effluents. CTGF expression was positively correlated with expression of lymphatic markers and VEGF-C in human peritoneal biopsies. We found a positive correlation between the increase in CTGF and the increase in VEGF-C in cultured human peritoneal mesothelial cells (HPMCs) treated with transforming growth factor-β1 (TGF-β1). The diaphragm is a central player in peritoneal lymphatic absorption. CTGF expression was also correlated with expression of VEGF-C and lymphatics in a rat diaphragmatic fibrosis model induced by chlorhexidine gluconate (CG). Furthermore, CTGF gene deletion reduced VEGF-C expression and peritoneal lymphangiogenesis in the mouse CG model. Inhibition of CTGF also reduced VEGF-C upregulation in HPMCs treated with TGF-β1. Our results suggest a close relationship between CTGF and PD-associated lymphangiogenesis.

DOI： 10.1038/s41598-019-48699-9

C4著明低値を示した抗H因子抗体陽性C3腎炎の1例

田中寿弥, 木谷昂志, 塩津弥生, 砂原康人, 山内紘子, 中村格, 山下紀行, 草場哲郎, 益澤尚子, 小西英一, 澤井俊宏, 水野正司, 玉垣圭一

日本腎臓学会誌 Vol. 61 ( 6 ) page： 877 - 877 2019.8

Mouse NC/Jic strain provides novel insights into host genetic factors for malaria research International journal

Ohno Tamio, Miyasaka Yuki, Kuga Masako, Ushida Kaori, Matsushima Miyoko, Kawabe Tsutomu, Kikkawa Yoshiaki, Mizuno Masashi, Takahashi Masahide

Experimental Animals Vol. 68 ( 3 ) page： 243 - 255 2019.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Association for Laboratory Animal Science

Malaria is caused by Plasmodium parasites and is one of the most life-threatening infectious diseases in humans. Infection can result in severe complications such as cerebral malaria, acute lung injury/acute respiratory distress syndrome, and acute renal injury. These complications are mainly caused by P. falciparum infection and are major causes of death associated with malaria. There are a few species of rodent-infective malaria parasites, and mice infected with such parasites are now widely used for screening candidate drugs and vaccines and for studying host immune responses and pathogenesis associated with disease-related complications. We found that mice of the NC/Jic strain infected with rodent malarial parasites exhibit distinctive disease-related complications such as cerebral malaria and nephrotic syndrome, in addition to a rapid increase in parasitemia. Here, we focus on the analysis of host genetic factors that affect malarial pathogenesis and describe the characteristic features, utility, and future prospects for exploitation of the NC/Jic strain as a novel mouse model for malaria research.

DOI： 10.1538/expanim.18-0185

Effects of long-term treatment with low-GDP, pH-neutral solutions on peritoneal membranes in peritoneal dialysis patients. Reviewed International journal

Tawada M, Hamada C, Suzuki Y, Sakata F, Sun T, Kinashi H, Katsuno T, Takei Y, Maruyama S, Honda K, Mizuno M, Ito Y

Clinical and experimental nephrology Vol. 23 ( 5 ) page： 689 - 699 2019.5

Differences in peritoneal solute transport rates in peritoneal dialysis. Reviewed

Marina Asano, Takako Ishii, Akiyoshi Hirayama, Masashi Mizuno, Yasuhiro Suzuki, Fumiko Sakata, Shin-Ichi Akiyama, Shoichi Maruyama, Tomoyoshi Soga, Hiroshi Kinashi, Takayuki Katsuno, Yasuhiko Ito

Clinical and experimental nephrology Vol. 23 ( 1 ) page： 122 - 134 2019.1

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Ultrafiltration failure associated with peritoneal membrane dysfunction is one of the main complications for patients on long-term peritoneal dialysis (PD). The dialysate-to-plasma concentration ratio (D/P) of creatinine is widely used to assess peritoneal membrane function. However, other small-sized solutes have not been studied in detail as potential indicators of peritoneal permeability. METHODS: We studied the D/Ps of small, middle-sized and large molecules in peritoneal equilibration tests in 50 PD patients. We applied metabolomic analysis of comprehensive small molecular metabolites using capillary electrophoresis time-of-flight mass spectrometry. RESULTS: D/Ps of middle-sized and large molecules correlated positively with D/P creatinine. Most D/Ps of small molecules correlated positively with D/P creatinine. Among 38 small molecules contained in the dialysate, urea, citrulline and choline showed significantly lower ability to permeate than creatinine. In the relationship between D/Ps of creatinine and small molecules, regression coefficients of three molecules were less than 0.3, representing no correlation to D/P creatinine. Five molecules showed negative regression coefficients. Among these molecules, hippurate and 3-indoxyl sulfate showed relatively high teinpro binding rates, which may affect permeability. Serum concentrations of two molecules were higher in the Low Kt/V group, mainly due to high protein binding rates. CONCLUSIONS: D/Ps of some molecules did not correlate with D/P creatinine. Factors other than molecular weight, such as charge and protein binding rate, are involved in peritoneal transport rates. Metabolomic analysis appears useful to analyze small molecular uremic toxins, which could accumulate in PD patients, and the status of peritoneal membrane transport for each molecule.

DOI： 10.1007/s10157-018-1611-1