Faculty Profiles - MIZUNO, Masashi

Papers - MIZUNO, Masashi

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Successful Introduction of Peritoneal Dialysis in an End-stage Renal Failure Patient with Idiopathic Aplastic Anemia Reviewed International journal

Suzuki Yasuhiro, Mizuno Masashi, Sakata Fumiko, Kojima Hiroshi, Sato Yuka, Kishimoto Mayuko, Suzuki Nobuaki, Kinashi Hiroshi, Saito Shoji, Katsuno Takayuki, Kosugi Tomoki, Maruyama Shoichi, Murata Makoto, Kiyoi Hitoshi, Ito Yasuhiko

Internal Medicine Vol. 59 ( 5 ) page： 683 - 687 2020

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine

A 45-year-old man with idiopathic aplastic anemia required renal replacement therapy (RRT) due to end-stage renal disease (ESRD). We succeeded in inserting the peritoneal dialysis (PD) catheter under cover of frequent red blood cell and platelet infusions because of severe pancytopenia. During the one-year period after starting PD using an ultraviolet-ray sterilization device, he developed severe leukopenia but no PD-related peritonitis or exit site/tunnel infection until he died of pneumonia. This case suggests that PD might be a suitable choice as RRT in ESRD patients with aplastic anemia, even in those with severe pancytopenia.

DOI： 10.2169/internalmedicine.3775-19

Dietary salt restriction during conservative therapy may prevent declines in residual renal function for the first year after starting peritoneal dialysis in patients with end-stage renal diseases Invited Reviewed International journal

Tetsuaki Hiramatsu, Masashi Mizuno, Yasuhiro Suzuki, Sumiyo Nomori, Yoshiko Shiga, Ting Sun, Takako Ishii, Hiroshi Kojima, Takayuki Katsuno, Tomohiro Nakamura, Tomoki Kosugi, Shoichi Maruyama, Tomio Koyama, Satoshi Noguchi, Yasuhiko Ito

Integrative Food, Nutrition and Metabolism Vol. 7 ( 1 ) 2020

Excessive salt intake increases peritoneal solute transport rate via local tonicity-responsive enhancer binding protein in subtotal nephrectomized mice. Reviewed International journal

Sun T, Sakata F, Ishii T, Tawada M, Suzuki Y, Kinashi H, Katsuno T, Takei Y, Maruyama S, Mizuno M, Ito Y

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Vol. 34 ( 12 ) page： 2031 - 2042 2019.12

CD55 EXPRESSION CHANGES IN MESOTHELIAL CELLS OF PATIENTS ON PERITONEAL DIALYSIS (PD) THERAPY

Ozeki Toshikazu, Mizuno Masashi, Kobayashi Kazuma, Iguchi Daiki, Sei Yumi, Suzuki Yasuhiro, Kojima Hiroshi, Fukui Sosuke, Yamashita Ryoko, Kinashi Hiroshi, Imai Masaki, Maruyama Shoichi, Ito Yasuhiko

MOLECULAR IMMUNOLOGY Vol. 114 page： 422 - 422 2019.10

Connective tissue growth factor is correlated with peritoneal lymphangiogenesis. Reviewed International coauthorship International journal

Hiroshi Kinashi, Naohiro Toda, Ting Sun, Tri Q Nguyen, Yasuhiro Suzuki, Takayuki Katsuno, Hideki Yokoi, Jan Aten, Masashi Mizuno, Shoichi Maruyama, Motoko Yanagita, Roel Goldschmeding, Yasuhiko Ito

Scientific reports Vol. 9 ( 1 ) page： 12175 - 12175 2019.8

Language：English Publishing type：Research paper (scientific journal)

Lymphatic absorption in the peritoneal cavity may contribute to ultrafiltration failure in peritoneal dialysis (PD). Lymphatic vessels develop during PD-related peritoneal fibrosis. Connective tissue growth factor (CTGF, also called CCN2) is an important determinant of fibrotic tissue remodeling, but little is known about its possible involvement in lymphangiogenesis. In this study, we investigated the relationship between CTGF and peritoneal lymphangiogenesis. A positive correlation was observed between vascular endothelial growth factor-C (VEGF-C), a major lymphangiogenic growth factor, and the CTGF concentration in human PD effluents. CTGF expression was positively correlated with expression of lymphatic markers and VEGF-C in human peritoneal biopsies. We found a positive correlation between the increase in CTGF and the increase in VEGF-C in cultured human peritoneal mesothelial cells (HPMCs) treated with transforming growth factor-β1 (TGF-β1). The diaphragm is a central player in peritoneal lymphatic absorption. CTGF expression was also correlated with expression of VEGF-C and lymphatics in a rat diaphragmatic fibrosis model induced by chlorhexidine gluconate (CG). Furthermore, CTGF gene deletion reduced VEGF-C expression and peritoneal lymphangiogenesis in the mouse CG model. Inhibition of CTGF also reduced VEGF-C upregulation in HPMCs treated with TGF-β1. Our results suggest a close relationship between CTGF and PD-associated lymphangiogenesis.

DOI： 10.1038/s41598-019-48699-9

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C4著明低値を示した抗H因子抗体陽性C3腎炎の1例

田中寿弥, 木谷昂志, 塩津弥生, 砂原康人, 山内紘子, 中村格, 山下紀行, 草場哲郎, 益澤尚子, 小西英一, 澤井俊宏, 水野正司, 玉垣圭一

日本腎臓学会誌 Vol. 61 ( 6 ) page： 877 - 877 2019.8

Mouse NC/Jic strain provides novel insights into host genetic factors for malaria research International journal

Ohno Tamio, Miyasaka Yuki, Kuga Masako, Ushida Kaori, Matsushima Miyoko, Kawabe Tsutomu, Kikkawa Yoshiaki, Mizuno Masashi, Takahashi Masahide

Experimental Animals Vol. 68 ( 3 ) page： 243 - 255 2019.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Association for Laboratory Animal Science

Malaria is caused by Plasmodium parasites and is one of the most life-threatening infectious diseases in humans. Infection can result in severe complications such as cerebral malaria, acute lung injury/acute respiratory distress syndrome, and acute renal injury. These complications are mainly caused by P. falciparum infection and are major causes of death associated with malaria. There are a few species of rodent-infective malaria parasites, and mice infected with such parasites are now widely used for screening candidate drugs and vaccines and for studying host immune responses and pathogenesis associated with disease-related complications. We found that mice of the NC/Jic strain infected with rodent malarial parasites exhibit distinctive disease-related complications such as cerebral malaria and nephrotic syndrome, in addition to a rapid increase in parasitemia. Here, we focus on the analysis of host genetic factors that affect malarial pathogenesis and describe the characteristic features, utility, and future prospects for exploitation of the NC/Jic strain as a novel mouse model for malaria research.

DOI： 10.1538/expanim.18-0185

Effects of long-term treatment with low-GDP, pH-neutral solutions on peritoneal membranes in peritoneal dialysis patients. Reviewed International journal

Tawada M, Hamada C, Suzuki Y, Sakata F, Sun T, Kinashi H, Katsuno T, Takei Y, Maruyama S, Honda K, Mizuno M, Ito Y

Clinical and experimental nephrology Vol. 23 ( 5 ) page： 689 - 699 2019.5

Differences in peritoneal solute transport rates in peritoneal dialysis. Reviewed

Marina Asano, Takako Ishii, Akiyoshi Hirayama, Masashi Mizuno, Yasuhiro Suzuki, Fumiko Sakata, Shin-Ichi Akiyama, Shoichi Maruyama, Tomoyoshi Soga, Hiroshi Kinashi, Takayuki Katsuno, Yasuhiko Ito

Clinical and experimental nephrology Vol. 23 ( 1 ) page： 122 - 134 2019.1

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Ultrafiltration failure associated with peritoneal membrane dysfunction is one of the main complications for patients on long-term peritoneal dialysis (PD). The dialysate-to-plasma concentration ratio (D/P) of creatinine is widely used to assess peritoneal membrane function. However, other small-sized solutes have not been studied in detail as potential indicators of peritoneal permeability. METHODS: We studied the D/Ps of small, middle-sized and large molecules in peritoneal equilibration tests in 50 PD patients. We applied metabolomic analysis of comprehensive small molecular metabolites using capillary electrophoresis time-of-flight mass spectrometry. RESULTS: D/Ps of middle-sized and large molecules correlated positively with D/P creatinine. Most D/Ps of small molecules correlated positively with D/P creatinine. Among 38 small molecules contained in the dialysate, urea, citrulline and choline showed significantly lower ability to permeate than creatinine. In the relationship between D/Ps of creatinine and small molecules, regression coefficients of three molecules were less than 0.3, representing no correlation to D/P creatinine. Five molecules showed negative regression coefficients. Among these molecules, hippurate and 3-indoxyl sulfate showed relatively high teinpro binding rates, which may affect permeability. Serum concentrations of two molecules were higher in the Low Kt/V group, mainly due to high protein binding rates. CONCLUSIONS: D/Ps of some molecules did not correlate with D/P creatinine. Factors other than molecular weight, such as charge and protein binding rate, are involved in peritoneal transport rates. Metabolomic analysis appears useful to analyze small molecular uremic toxins, which could accumulate in PD patients, and the status of peritoneal membrane transport for each molecule.

DOI： 10.1007/s10157-018-1611-1

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HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy Reviewed International journal

Kawakita Chieko, Kinomura Masaru, Otaka Nozomu, Kitagawa Masashi, Sugiyama Hitoshi, Kusano Nobuchika, Mizuno Masashi, Wada Jun

Internal Medicine Vol. 58 ( 20 ) page： 3001 - 3007 2019

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine

A 57-year-old man was diagnosed with IgA nephropathy. Hematuria and proteinuria were improved by tonsillectomy plus methylprednisolone pulse therapy. Lymphadenopathy, hypocomplementemia and pancytopenia were observed six years later, and urinalysis abnormalities recurred. A biopsy revealed mesangial proliferative glomerulonephritis with C3-dominant deposition. Human immunodeficiency virus (HIV) antibody demonstrated positive conversion. He was diagnosed with HIV-associated immune complex kidney disease (HIVICK). The hematuria, proteinuria and hypocomplementemia were improved by reducing the HIV viral load through antiretroviral therapy. When C3-dominant deposition is observed on a renal biopsy, HIVICK must be differentiated.

DOI： 10.2169/internalmedicine.2439-18

Investigation on the benefits of mycophenolate mofetil and therapeutic drug monitoring in the treatment of Japanese patients with lupus nephritis Reviewed International journal

Takayuki Katsuno, Takenori Ozaki, Takaya Ozeki, Asaka Hachiya, Hangsoo Kim, Noritoshi Kato, Takuji Ishimoto, Sawako Kato, Tomoki Kosugi, Naotake Tsuboi, Masashi Mizuno, Yasuhiko Ito, Shoichi Maruyama

Clinical and Experimental Nephrology Vol. 22 ( 6 ) page： 1341 - 1350 2018.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Tokyo

Background: Mycophenolate mofetil (MMF) is recommended as a first-line immunosuppressant to treat lupus nephritis (LN). Prognosis and therapeutic response in LN are known to vary depending on race. We investigated the benefits of MMF and therapeutic drug monitoring (TDM) in the treatment of Japanese LN patients. Methods: In this retrospective cohort study, a total of 20 patients with LN who started MMF treatment were included. Clinical data were collected regularly after MMF administration. We evaluated complete remission (CR) rate as the primary outcome. Predictors of CR were identified using univariate and multivariate analyses. In the research of TDM, the correlation with the area under the curve (AUC) was analyzed at MMF dose, single-point value, treatment response, and adverse events. Results: Overall, 70% of cases showed CR
both flare-ups and refractory cases had favorable results. Cases of LN with nephrotic syndrome (NS) or class III/IV + V showed a significantly lower CR rate (p &lt
0.005). The ratio of maintaining CR after MMF therapy was as high as 85.7%. In multivariate analysis, NS was an independent negative predictor of CR (HR 0.09, 95% confidence interval 0.01–0.81
p = 0.03). The relationship between AUC and MMF dose was low, and AUC correlated with trough level (r = 0.73). AUC tended to be high in the treatment responder (p = 0.09), but did not correlate with adverse events of infection (p = 0.92). Conclusion: MMF is a beneficial treatment option for Japanese LN patients, and further investigation on TDM-based therapy is needed.

DOI： 10.1007/s10157-018-1590-2

Anti-C5a complementary peptide mitigates zymosan-induced severe peritonitis with fibrotic encapsulation in rat pretreated with methylglyoxal. Reviewed International journal

Iguchi D, Mizuno M, Suzuki Y, Sakata F, Maruyama S, Okada A, Okada H, Ito Y

American journal of physiology. Renal physiology Vol. 315 ( 6 ) page： F1732 - F1746 2018.12

Peritoneal expression of membrane complement regulators in peritoneal dialysis patients with fungal peritonitis

Fukui Sosuke, Suzuki Yasuhiro, Tawada Mitsuhiro, Matsukawa Yoshihisa, Imai Masaki, Maruyama Shoichi, Ito Yasuhiko, Mizuno Masashi

MOLECULAR IMMUNOLOGY Vol. 102 page： 152 - 152 2018.10

Extracellular histones decrease the expression of membrane complement regulators Reviewed International journal

Mizuno Tomohiro, Nagano Fumihiko, Mizuno Masashi, Iwata Ayumi, Takahashi Kazuo, Tsuboi Naotake, Maruyama Shoichi, Nagamatsu Tadashi, Imai Masaki

MOLECULAR IMMUNOLOGY Vol. 102 page： 189-189 2018.10

Comprehensive analysis of complement proteins and genes in thrombotic microangiopathy in Japan

Hidaka, Y; Inoue, N; Ohtani, K; Ohtsuka, Y; Sawai, T; Miyata, T; Ohsawa, I; Okada, H; Kinoshita, T; Sekine, H; Tsukamoto, H; Nakao, M; Mizuno, M; Murakami, Y; Horiuchi, T; Wakamiya, N

MOLECULAR IMMUNOLOGY Vol. 102 page： 163 - 163 2018.10

SODIUM RESTRICTED DIET DURING CONSERVATIVE THERAPY IN PATIENTS WITH END-STAGE RENAL DISEASES (ESRD) MAY RESCUE RESIDUAL RENAL FUNCTION (RRF) FOR THE FIRST YEAR AFTER STARTING PERITONEAL DIALYSIS (PD)

Hiramatsu Tetsuaki, Mizuno Masashi, Nomori Sumiyo, Sakata Fumiko, Suzuki Yasuhiro, Maruyama Shoichi, Yasuhiko Ito, Noguchi Satoshi

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 33 page： . 2018.5

高齢腹膜透析患者の地域連携における現状と課題

伊藤恭彦, 水野正司, 鈴木康弘, 杉山斉, 深水圭, 猪阪善隆

医工学治療 Vol. 30 ( Suppl. ) page： 161 - 161 2018.3

TGF-beta 1-VEGF-A pathway induces neoangiogenesis with peritoneal fibrosis in patients undergoing peritoneal dialysis Reviewed International journal

Kariya Tetsuyoshi, Nishimura Hayato, Mizuno Masashi, Suzuki Yasuhiro, Matsukawa Yoshihisa, Sakata Fumiko, Maruyama Shoichi, Takei Yoshifumi, Ito Yasuhiko

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY Vol. 314 ( 2 ) page： F167 - F180 2018.2

Current Status of Peritoneal Dialysis in Japan. Reviewed International coauthorship International journal

Ito Y, Tawada M, Tine S, Mizuno M, Suzuki Y, Katsuno T

Contributions to nephrology Vol. 196 page： 123 - 128 2018

Peritoneal eosinophils increase during induction of peritoneal dialysis and may be related to production of C3a in peritoneal dialysate

Mizuno Masashi, Shigemoto Emi, Kobayashi Kazuma, Iguchi Daiki, Sakata Fumiko, Suzuki Yasuhiro, Maruyama Shoichi, Ito Yasuhiko

MOLECULAR IMMUNOLOGY Vol. 89 page： 193-193 2017.9

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Papers - MIZUNO, Masashi