Faculty Profiles - MIZUNO, Masashi

Papers - MIZUNO, Masashi

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特集透析療法の課題,展望総論腹膜透析の現状と残された課題

水野正司, 金恒秀, 福井聡介, 鈴木康弘

腎と透析 Vol. 98 ( 1 ) page： 13 - 17 2025.1

Successfully treated C3 glomerulopathy in which protein and genetic analyses were useful for diagnosis. Reviewed

Kanzaki M, Kurahashi M, Watanabe K, Nishikawa M, Fukuoka K, Shimada N, Mizuno M, Asano K.

CEN Case Rep. Vol. 14 page： 188 - 193 2025

特集腎疾患の診断と治療最前線 II.各論1:糸球体疾患(診断と治療) 12.C3腎症 Invited

水野正司

腎と透析 Vol. 97 ( 7 ) page： 130 - 135 2024.12

Delaying treatment for peritonitis could be related to longer hospitalization in patients on peritoneal dialysis Reviewed International journal Open Access

Koshitori, Y; Takai, N; Isomura, Y; Hiramatsu, T; Suzuki, Y; Kim, H; Fukui, S; Mizuno, M

RENAL REPLACEMENT THERAPY Vol. 10 ( 1 ) 2024.11

Successfully treated C3 glomerulopathy in which protein and genetic analyses were useful for diagnosis. Reviewed International journal

Kanzaki M, Kurahashi M, Watanabe K, Nishikawa M, Fukuoka K, Shimada N, Mizuno M, Asano K

CEN case reports 2024.9

Pathophysiological Mechanisms of Peritoneal Fibrosis and Peritoneal Membrane Dysfunction in Peritoneal Dialysis. Reviewed International journal

Yasuhiko Ito, Ting Sun, Mitsuhiro Tawada, Hiroshi Kinashi, Makoto Yamaguchi, Takayuki Katsuno, Hangsoo Kim, Masashi Mizuno, Takuji Ishimoto

International journal of molecular sciences Vol. 25 ( 16 ) 2024.8

Language：English Publishing type：Research paper (scientific journal)

The characteristic feature of chronic peritoneal damage in peritoneal dialysis (PD) is a decline in ultrafiltration capacity associated with pathological fibrosis and angiogenesis. The pathogenesis of peritoneal fibrosis is attributed to bioincompatible factors of PD fluid and peritonitis. Uremia is associated with peritoneal membrane inflammation that affects fibrosis, neoangiogenesis, and baseline peritoneal membrane function. Net ultrafiltration volume is affected by capillary surface area, vasculopathy, peritoneal fibrosis, and lymphangiogenesis. Many inflammatory cytokines induce fibrogenic growth factors, with crosstalk between macrophages and fibroblasts. Transforming growth factor (TGF)-β and vascular endothelial growth factor (VEGF)-A are the key mediators of fibrosis and angiogenesis, respectively. Bioincompatible factors of PD fluid upregulate TGF-β expression by mesothelial cells that contributes to the development of fibrosis. Angiogenesis and lymphangiogenesis can progress during fibrosis via TGF-β-VEGF-A/C pathways. Complement activation occurs in fungal peritonitis and progresses insidiously during PD. Analyses of the human peritoneal membrane have clarified the mechanisms by which encapsulating peritoneal sclerosis develops. Different effects of dialysates on the peritoneal membrane were also recognized, particularly in terms of vascular damage. Understanding the pathophysiologies of the peritoneal membrane will lead to preservation of peritoneal membrane function and improvements in technical survival, mortality, and quality of life for PD patients.

DOI： 10.3390/ijms25168607

PubMed

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特集補体と腎疾患:温故知新腎疾患における補体と病態生理膜性増殖性糸球体腎炎/C3腎症 Invited International journal

水野正司

腎と透析 Vol. 97 ( 1 ) page： 82 - 87 2024.7

Effectiveness of additional topical antibiotics for recurrent or refractory exit-site infection: a case series Reviewed International journal

Asai, N; Suzuki, Y; Asai, A; Kinashi, H; Kamiya, K; Hagita, J; Matsuoka, N; Kawamura, S; Fukui, S; Kim, H; Yamaguchi, M; Katsuno, T; Mizuno, M; Ishimoto, T; Ito, Y

RENAL REPLACEMENT THERAPY Vol. 10 ( 1 ) 2024.6

Rationale and design of the Japanese Biomarkers in Nephrotic Syndrome (J-MARINE) study Reviewed International journal

Kurasawa, S; Kato, S; Ozeki, T; Akiyama, S; Ishimoto, T; Mizuno, M; Tsuboi, N; Kato, N; Kosugi, T; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY Vol. 28 ( 5 ) page： 431 - 439 2024.5

Durvalumab plus carboplatin-etoposide treatment in a patient with small-cell lung cancer on hemodialysis: a case report and literature review. Reviewed International journal

Ushijima F, Hase T, Yamashita Y, Kim H, Shimokata T, Kondo C, Sato T, Baba T, Watanabe S, Futamura K, Ando Y, Mizuno M, Ishii M

International cancer conference journal Vol. 13 ( 2 ) page： 88 - 92 2024.4

Role of endothelial hyaluronan in peritoneal membrane transport and disease conditions during peritoneal dialysis Reviewed International coauthorship International journal

Kamiya, K; Hatayama, N; Tawada, M; Asai, A; Yamauchi, M; Kinashi, H; Kunoki, S; Yamaguchi, M; Mizuno, M; Suzuki, Y; Banshodani, M; Ishimoto, T; Naito, M; Kawanishi, H; Ito, Y

SCIENTIFIC REPORTS Vol. 14 ( 1 ) page： 7412 2024.3

Role of endothelial hyaluronan in peritoneal membrane transport and disease conditions during peritoneal dialysis. Reviewed Open Access

Kamiya K, Hatayama N, Tawada M, Asai A, Yamauchi M, Kinashi H, Kunoki S, Yamaguchi M, Mizuno M, Suzuki Y, Banshodani M, Ishimoto T, Naito M, Kawanishi H, Ito Y.

Sci Rep. Vol. 14 ( 1 ) page： 7412 2024.3

A Case of C3 Nephritis With a Rare Variant of the CFHR5 Gene Reviewed International journal Open Access

Kamido, H; Yamamoto, S; Yokoi, H; Mizuno, M; Yanagita, M

CUREUS JOURNAL OF MEDICAL SCIENCE Vol. 16 ( 2 ) page： e55102 2024.2

今月の特集2 補体をめぐる話題注目の補体異常症 C3腎症

金恒秀, 水野正司

臨床検査 Vol. 68 ( 1 ) page： 88 - 92 2024.1

Delaying treatment for peritonitis could be related to longer hospitalization in patients on peritoneal dialysis. Reviewed Open Access

Koshitori Y, Takai N, Isomura Y, Hiramatsu T, Suzuki Y, Kim H, Fukui S, Mizuno M.

Renal Replacement Therapy 2024

Pathophysiological Mechanisms of Peritoneal Fibrosis and Peritoneal Membrane Dysfunction in Peritoneal Dialysis. Invited Reviewed Open Access

2024

Effectiveness of additional topical antibiotics for recurrent or refractory exit-site infection: a case series. Reviewed Open Access

Asai N, Suzuki Y, Asai A, Kinashi H, Kamiya K, Hagita J, Matsuoka N, Kawamura S, Fukui S, Kim H, Yamaguchi M, Katsuno, T, Mizuno M, Ishimoto T, Ito Y.

Renal Replacement Therapy. Vol. 10 page： 32 2024

特集補体revisited--抗補体療法はどこまで進んだか? 非典型溶血性尿毒症症候群 Invited

水野正司

医学のあゆみ Vol. 287 ( 10 ) page： 757 - 761 2023.12

遺伝性血管性浮腫(Hereditary angioedema:HAE)診療ガイドライン改訂2023年版

堀内孝彦, 大澤勲, 宮田敏行, 赤津裕康, 今井優樹, 大谷克城, 奥健志, 関根英治, 塚本浩, 中尾実樹, 西村純一, 水野正司, 村上良子, 井上徳光, 一般社団法人日本補体学会HAEガイドライン作成委員会

補体 Vol. 60 ( 1 ) page： 23 - 23 2023.8

学校検尿でみつかった、電顕像にて電子密度の異なる沈着物を認めるDense Deposit Diseaseの13歳女児例

手塚優子, 新野亮治, 木内拓海, 岡本健太郎, 村上至孝, 松田修, 澤井俊宏, 水野正司, 清水章

日本小児腎臓病学会雑誌 Vol. 36 ( Suppl. ) page： 179 - 179 2023.5

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Papers - MIZUNO, Masashi