Faculty Profiles - MIZUNO, Masashi

Papers - MIZUNO, Masashi

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Complement and complement regulators in the male reproductive system. Invited Reviewed

Harris CL., Mizuno M., Morgan BP.

Mol Immunol Vol. 43 page： 57-67 2006

Complement membrane attack is required for endplate damage and clinical disease in experimental myasthenia gravis in Lewis rats. Reviewed

Chamberlain-Banoub J., Neal JW., Mizuno M., Harris CL., Morgan BP.

Clin Exp Immunol Vol. 146 page： 278-286 2006

CD55 expression in rat male reproductive tissue: Differential expression in testis and expression of a unique truncated isoform on spermatozoa. Reviewed

Mizuno M., Donev RM., Harris CL., Morgan BP.

Mol. Immunol. Vol. 44 page： 1624-1633 2006

A review of current knowledge of the complement system and the therapeutic opportunities in inflammatory arthritis. Invited Reviewed

Mizuno M.

Curr Med Chem Vol. 13 page： 1707-1717 2006

Unique expression patterns of membrane complement regulators and C3 in rat testes and spermatozoa delineate the blood-testis barrier and suggest distinct functional roles in germ cell development. Reviewed

Mizuno M., Harris CL., Morgan BP.

J Reprod Immunol Vol. 69 page： 23-34 2006

Mizuno M, Harris CL, Morgan BP

J Reprod Immunol Vol. 69 page： 23-34 2006

Shiga toxin 1causes direct renal injury in rats Reviewed International journal

Yamamoto ET, Mizuno M, Nishikawa K, Miyazawa S, Zhang LS, Matsuo S, Natori Y

INFECTION AND IMMUNITY Vol. 73 ( 11 ) page： 7099 - 7106 2005.11

Novel C5a regulators in inflammatory disease Invited Reviewed International journal

M Mizuno, DS Cole

EXPERT OPINION ON INVESTIGATIONAL DRUGS Vol. 14 ( 7 ) page： 807 - 821 2005.7

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：ASHLEY PUBLICATIONS LTD

Complement is part of the innate immune system, acting to protect the host from microorganisms such as bacteria, and other foreign and abnormal cells. Although primarily protective, complement activation can also cause damage to the host. In a number of inflammatory diseases, including rheumatoid arthritis and dermatitis, there is excessive and inappropriate complement activation. Many of the toxic effects seen in these conditions are attributable to the excessive production of the anaphylatoxin C5a, which may contribute to both the initiation and progression of the disease. Therefore, the regulation of C5a production and modulation of its function are good pharmacological targets in these disorders. As yet, there are no effective agents for the therapeutic regulation of C5a in routine clinical practice. This review describes the role of C5a in inflammatory disease, animal models used to study C5a-related effects, and current strategies aimed at regulating C5a. There is also a discussion of the strengths and weaknesses of these approaches, and an outline of the likely progress of this class of drugs in the future.

DOI： 10.1517/13543784.14.7.807

Web of Science

PubMed

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Expression of CD46 in developing rat spermatozoa: ultrastructural localisation and utility as a marker of the various stages of the seminiferous tubuli. Reviewed

Mizuno M., Harris CL., Suzuki N., Matsuo S., Morgan BP.

Biol Reprod Vol. 72 page： 908-915 2005

Shiga toxin-1 causes direct renal injury in rats. Reviewed

Yamamoto ET., Mizuno M., Nishikawa K., Miyazawa S., Zhang L., Matsuo S., Natori Y.

Infect Immun Vol. 73 page： 7099-7106 2005

Novel C5a regulators in inflammation. Invited Reviewed

Mizuno M., Cole DS.

Expert Opin Investig Drugs Vol. 14 page： 807-821 2005

CD59a is the primary regulator of membrane attack complex assembly in the mouse.

Baalasubramanian S, Harris CL, Donev RM, Mizuno M, Omidvar N, Song WC, Morgan BP

Journal of immunology (Baltimore, Md. : 1950) Vol. 173 ( 6 ) page： 3684 - 92 2004.9

Inummohistochemical analysis of membrane complement regulatory proteins in rat testis: unique roles for DAF and MCP in spermatozoal function?

Mizuno, M; Harris, CL; Morgan, BP

MOLECULAR IMMUNOLOGY Vol. 41 ( 2-3 ) page： 280 - 280 2004.6

The possibilities and pitfalls for anti-complement therapies in inflammatory diseases. Invited Reviewed

Mizuno M., Morgan BP.

Current Drug Targets Inflammation & Allergy Vol. 3 page： 85-94 2004

CD59a is the primary regulator of membrane attack complex assembly in the mouse. Reviewed

Baalasubramanian S., Harris CL., Donev RM., Mizuno M., Omidvar N., Song W., Morgan BP.

J. Immunol. Vol. 173 page： 3684-3692 2004

Rat membrane cofactor protein (MCP; CD46) is expressed only in the acrosome of developing and mature spermatozoa and mediates binding to immobilized activated C3. Reviewed

Mizuno M., Harris CL., Johnson PM., Morgan BP.

Biol Reprod Vol. 71 page： 1374-1383 2004

Deletion of the gene encoding CD59a in mice increases disease severity in a murine model of rheumatoid arthritis. Reviewed

Williams AS., Mizuno M., Richards PJ., Holt DS., Morgan BP

Arthritis Rheum Vol. 50 page： 3035-3044 2004

In two patients on long-term hemodialysis, Etidronate Disodium improved their discomfort and extremities' blood flow associated with severe abnormal arterial wall calcification. Reviewed

Mizuno M., Kashima N., Kato K., Ito A, Matsuo S.

Clin Drug Invest Vol. 24 page： 365-371 2004

Improvement in Discomfort and Decreased Blood Flow Associated with Severe Arterial Wall Calcification following Etidronic Acid. Reviewed International journal

Mizuno M, Kashima N, Kato K, Ito A, Matsuo S

Clinical drug investigation Vol. 24 ( 6 ) page： 365 - 71 2004

Implication of the complement system in the induction of antiglomerular basement membrane glomerulonephritis in WKY rats Reviewed International journal

SHIKE Tatsuhiko, ISOME Masato, MIZUNO Masashi, SUZUKI Junzo, MATSUO Seiichi, YAMAMOTO Tadashi, SUZUKI Hitoshi

Pathol Int Vol. 53 ( 11 ) page： 757 - 761 2003.11

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Papers - MIZUNO, Masashi