Faculty Profiles - NAGANAWA, Shinji

Papers - NAGANAWA, Shinji

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Sudden sensorineural hearing loss associated with inner ear anomaly. Reviewed

Sugiura M, Nakashima T, Naganawa S, Otake Y, Mukaida T, Sone M, Sato E

Otol Neurotol Vol. 26 ( 2 ) page： 241-246 2005

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: This study was conducted to evaluate the frequency of inner ear anomaly in patients with sudden sensorineural hearing loss and in control subjects. STUDY DESIGN: Retrospective case review. SETTING: A tertiary referral center. PATIENTS AND INTERVENTION: We evaluated 366 patients (165 men and 201 women; age range, 3-91 yr) with sudden sensorineural hearing loss and 228 control subjects without sensorineural hearing loss using magnetic resonance imaging. Three hundred fifty-six patients had unilateral and 10 patients had bilateral sudden sensorineural hearing loss. RESULTS: Eleven (2.9%) of 376 ears with sudden sensorineural hearing loss had inner ear anomaly. Nine patients (2.5%) had inner ear anomaly associated with sudden sensorineural hearing loss, but none of the 228 control subjects had the anomaly. The current study demonstrated that the frequency of inner ear anomaly in patients with sudden sensorineural hearing loss was significantly higher than in control subjects. CONCLUSION: Our study reveals that inner ear anomaly may be associated with sudden sensorineural hearing loss in 2.5% of patients.

DOI： 10.1097/00129492-200503000-00019

Apparent diffusion coefficient in cervical cancer of the uterus: comparison with the normal uterine cervix. Reviewed

Naganawa S, Sato C, Kumada H, Ishigaki T, Miura S, Takizawa O

Eur Radiol Vol. 15 ( 1 ) page： 71-78 2005

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

A relation between apparent diffusion coefficient (ADC) values and tumor cellular density has been reported. The purpose of this study was to measure the ADC values of cervical cancers in the uterus and compare them with those of normal cervical tissues, and to test whether ADC could differentiate between normal and malignant cervical tissues in the uterus. Twelve consecutive female patients with cervical cancer of the uterus and ten female patients with other pelvic abnormalities were included in this study. ADC was measured at 1.5 T with b-factors of 0, 300 and 600 s/mm2 using single-shot echo-planar diffusion-weighted imaging and a parallel imaging technique. The mean ADC value of cervical cancer lesions was 1.09+/-0.20 x 10(-3) mm2/s, and that of normal cervix tissue was 1.79+/-0.24 x 10(-3) mm2/s (P<0.0001). In nine patients treated by chemotherapy and/or radiation therapy, the mean ADC value of the cervical cancer lesion increased significantly after therapy (P<0.001). The present study showed, with a small number of patients, that ADC measurement has a potential ability to differentiate between normal and cancerous tissue in the uterine cervix. Further study is necessary to determine the accuracy of ADC measurement in monitoring the treatment response.

DOI： 10.1007/s00330-004-2529-4

Long-term follow-up in patients with Pendred syndrome: vestibular, auditory and other phenotypes. Reviewed

Sugiura M, Sato E, Nakashima T, Sugiura J, Furuhashi A, Yoshino T, Nakayama A, Mori N, Murakami H, Naganawa S

Eur Arch Otorhinolaryngol Vol. 262 ( 9 ) page： 737-743 2005

Language：English Publishing type：Research paper (scientific journal)

Fourteen patients with a Pendred syndrome gene (Pds) mutation and three patients without the mutation were studied to evaluate long-term vestibular and auditory manifestations among patients with bilateral enlarged vestibular aqueducts (EVA). Charts were reviewed retrospectively for age, gender, otological history, presence or absence of vertigo, results of magnetic resonance imaging, relevant gene mutations and perchlorate discharge test. A missense mutation, His 723 Arg (H723R), was identified in the homozygous state in six patients and in the heterozygous state in seven patients. Another missense mutation, Tyr 410 Met (T410 M), was identified in the heterozygous state in one patient. Patients with vertigo tended to have hearing fluctuation, compared with the patients without vertigo. Patients homozygous for H723R tended to have more episodes of vertigo than the heterozygous individuals. Only one patient who was homozygous for H723R had goiter. The long-term outcome of hearing level in patients with the H723R mutation was significantly better compared with published results for patients with a Pds mutation, but not for those with the H723R mutation. Whether environmental factors or a subtype of the Pds mutation H723R are related to the long-term outcome for these patients must be clarified.

DOI： 10.1007/s00405-004-0884-z

Contralateral and ipsilateral responses in primary somatosensory cortex following electrical median nerve stimulation--an fMRI study. Reviewed

Nihashi T, Naganawa S, Sato C, Kawai H, Nakamura T, Fukatsu H, Ishigaki T, Aoki I

Clin Neurophysiol Vol. 116 ( 4 ) page： 842-848 2005

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Ten healthy adult subjects were examined using functional magnetic resonance imaging (fMRI) to investigate responses in the contralateral and ipsilateral primary somatosensory cortex (SI) following electrical stimulation of the median nerve. METHODS: The right and left median nerves were stimulated alternately at the wrist in the different sessions. First, the location of the response in contralateral SI was identified following median nerve stimulation, and then, a spherical search volume with a 10mm radius centered on the region of the contralateral response was determined. Whether or not fMRI activation occurred within this sphere following ipsilateral stimulation was examined using a 3T MR imager. RESULTS: A response in contralateral SI was observed in 8 of the 10 subjects in right and left hemisphere. Responses in ipsilateral SI were observed in 6 of 8 subjects in right hemisphere, and the region of the response tended to be posterior to the contralateral region. On the other hand, in left hemisphere, the ipsilateral responses were found in three. CONCLUSIONS: In the present study, not only contralateral SI but also ipsilateral SI was activated following median nerve. The location of the ipsilateral activation was significantly more posterior than the contralateral one in right hemisphere. SIGNIFICANCE: The region of activation in ipsilateral SI was located in the posterior portion of post central gyrus, corresponding to around BA2 and 5 in human.

【最近の画像診断の進歩　CT,MRI,PET】　高磁場MRI

長縄慎二

日本医師会雑誌 Vol. 134 page： 1722-1726 2005

多発性硬化症におけるIsotropic 3D FLAIR法の有用性

末永正機, 伊藤瑞規, 熱田直樹, 渡邉宏久, 祖父江元, 深津博, 長縄慎二

臨床神経学 Vol. 45 page： 1035 2005

多系統萎縮症とパーキンソン病の鑑別　橋の拡散テンソル画像,拡散強調画像の有用性

伊藤瑞規, 熱田直樹, 川合圭成, 渡邉宏久, 祖父江元, 長縄慎二, 深津博, 石垣武男

臨床神経学 Vol. 45 page： 1168 2005

多系統萎縮症における認知機能障害　画像との関連

川合圭成, 伊藤瑞規, 渡邉宏久, 祖父江元, 武田章敬, 長縄慎二, 深津博, 加藤克彦, 石垣武男

臨床神経学 Vol. 45 page： 1185 2005

【医療環境の変化に対して放射線診療は今後どう対応すべきか　画像診断を中心に】　高度画像診断機器導入による画像診断へのインパクト　医療制度の変化を踏まえて　超高磁場MRIのインパクト(3T MRIを含めて)　脳以外への活用方法

長縄慎二

日独医報 Vol. 50 page： 479-489 2005

第３３回日本磁気共鳴医学会大会にみるBody diffusionの動向

長縄慎二

Innervision Vol. 20 ( 12 ) page： 112 2005

高磁場MRI

長縄慎二

日本医師会雑誌 Vol. 134 ( 9 ) page： 1722-1726 2005

超高磁場MRIのインパクト(3T MRIをふくめて）脳以外への活用方法

長縄慎二

日独医報 Vol. 50 ( 3 ) page： 479-489 2005

前立腺癌，子宮頸癌におけるADC測定の意義

長縄慎二

画像診断 Vol. 25 ( 6 ) page： 737-743 2005

Authorship：Lead author Language：Japanese

DWIBSにおいての癌描出のメカニズムは十分に把握されておらず，基礎的な検討としても，現時点での臨床的な課題としても，さまざまな種類の癌のADCを測定することが重要である．前立腺癌と子宮頸癌におけるADC計測の結果と臨床的な位置付けを1.5T，3Tでの結果に基づいて解説する

電子ポスター(Cypos)元年　JRC2005を振り返って

石垣武男　藤田広志　深津博　長縄慎二　片渕哲朗　原武史

Innervision Vol. 20 ( 7 ) page： 28-33 2005

第64回日本医学放射線学会学術集会　イメージインタープリテーションセッション症例出題集

長縄慎二、原真咲

日本医学放射線学会誌別冊付録 Vol. 65 ( 3 ) page： 1-28 2005

第64回日本医学放射線学会学術集会　イメージインタープリテーションセッション症例出題集

長縄慎二、原真咲

日本医学放射線学会誌別冊付録 Vol. 65 ( 2 ) page： 1-14 2005

Serial evaluation of diffusion tensor brain fiber tracking in a patient with severe diffuse axonal injury. Reviewed

Naganawa S, Sato C, Ishihra S, Kumada H, Ishigaki T, Miura S, Watanabe M, Maruyama K, Takizawa O

AJNR Am J Neuroradiol Vol. 25 ( 9 ) page： 1553-1556 2004.10

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

Serial evaluation of diffusion tensor brain fiber tracking was performed in a 27-year-old female patient with diffuse axonal injury after a traffic accident. Although the result of brain fiber tracking was not necessarily parallel to her clinical symptoms, it may have predicted the neurologic prognosis.

Rad Talk ISMRM2004

長縄慎二

Rad Fan Vol. 2 ( 6 ) page： 47-56 2004.10

High-speed imaging at 3 Tesla: a technical and clinical review with an emphasis on whole-brain 3D imaging. Reviewed

Naganawa S, Kawai H, Fukatsu H, Ishigaki T, Komada T, Maruyama K, Takizawa O

Magn Reson Med Sci Vol. 3 ( 4 ) page： 177-187 2004

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

Improvements to the inherently high specific-absorption rate (SAR) of high-speed imaging at 3T are necessary in order to render this method clinically feasible. Various efforts have been undertaken to improve the associated hardware and software. In this review, we focus on whole-brain isotropic 3D imaging with a turbo spin-echo sequence with variable flip-angle echo trains (3D-TSE-VFL) and present its technical and clinical features. This sequence can be used to acquire images of various contrasts including T2-weighted, fat-suppressed T2-weighted, fluid-attenuated inversion recovery (FLAIR), fat-suppressed FLAIR, and STIR (short tau inversion recovery). Various aspects of 3D-TSE-VFL are discussed, including CSF (cerebrospinal fluid) and metal artifacts, STIR contrast, small-part visualization other than brain, and the possibility of serial subtraction. Some images from clinical cases are presented.

MR imaging of gastric cancer in vitro: accuracy of invasion depth diagnosis.

Sato C, Naganawa S, Kumada H, Miura S, Ishigaki T

Eur Radiol Vol. 14 ( 9 ) page： 1543-1549 2004

Language：English Publishing type：Research paper (scientific journal)

The purpose of this study was to evaluate the accuracy of grading cancerous invasion of the gastric wall in vitro using magnetic resonance (MR) imaging. Twelve specimens of gastric carcinoma were examined at 1.5-T using a small, loop surface coil. They were imaged within 2 days of fixation in formalin. The field of view was 30 mm; the matrix size was 256x256, and the section thickness was 2 mm. T1-weighted, T2-weighted and short inversion time inversion recovery (STIR) images were obtained. Two radiologists evaluated the MR images independently, and in discrepant cases, consensus was obtained through discussion. Findings on MR images were compared with histopathologic findings. All T1-weighted, T2-weighted and STIR images depicted the normal gastric wall as consisting of six layers. STIR images depicted normal six layers most clearly. Histologically, the cancerous invasion was found to extend into the mucosa in 4 of the 12 specimens, the submucosa in 3, the muscularis propria in 2, the subserosa in 2 and the serosa in 1. The grading by MR imaging matched the histopathologic findings for all 12 tumors. The overall accuracy was 100%. Thus, MR imaging in vitro was sufficiently accurate for grading cancerous invasion of the gastric wall.

DOI： 10.1007/s00330-004-2362-9

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Papers - NAGANAWA, Shinji