Faculty Profiles - NAGANAWA, Shinji

Papers - NAGANAWA, Shinji

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Abnormal Flow Dynamics Result in Low Wall Shear Stress and High Oscillatory Shear Index in Abdominal Aortic Dilatation: Initial in vivo Assessment with 4D-flow MRI. Reviewed

Yasuo Takehara, Haruo Isoda, Mamoru Takahashi, Naoki Unno, Norihiko Shiiya, Takasuke Ushio, Satoshi Goshima, Shinji Naganawa, Marcus Alley, Tetsuya Wakayama, Atsushi Nozaki

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine Vol. 19 ( 3 ) page： 235 - 246 2020

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To characterize the non-laminar flow dynamics and resultant decreased wall shear stress (WSS) and high oscillatory shear index (OSI) of the infrarenal abdominal aortic dilatation, cardiac phase-resolved 3D phase-contrast MRI (4D-flow MRI) was performed. METHODS: The prospective single-arm study was approved by the Institutional Review Board and included 18 subjects (median 67.5 years) with the dilated infrarenal aorta (median diameter 35 mm). 4D-flow MRI was conducted on a 1.5T MRI system. On 3D streamline images, laminar and non-laminar (i.e., vortex or helical) flow patterns were visually assessed both for the dilated aorta and for the undilated upstream aorta. Cardiac phase-resolved flow velocities, WSS and OSI, were also measured for the dilated aorta and the upstream undilated aorta. RESULTS: Non-laminar flow represented by vortex or helical flow was more frequent and overt in the dilated aorta than in the undilated upstream aorta (P < 0.0156) with a very good interobserver agreement (weighted kappa: 0.82-1.0). The WSS was lower, and the OSI was higher on the dilated aortic wall compared with the proximal undilated segments. In mid-systole, mean spatially-averaged WSS was 0.20 ± 0.016 Pa for the dilated aorta vs. 0.68 ± 0.071 Pa for undilated upstream aorta (P < 0.0001), and OSI on the dilated aortic wall was 0.093 ± 0.010 vs. 0.041 ± 0.0089 (P = 0.013). The maximum values and the amplitudes of the WSS at the dilated aorta were inversely proportional to the ratio of dilated/undilated aortic diameter (r = -0.694, P = 0.0014). CONCLUSION: 4D-flow can characterize abnormal non-laminar flow dynamics within the dilated aorta in vivo. The wall of the infrarenal aortic dilatation is continuously and increasingly affected by atherogenic stimuli due to the flow disturbances represented by vortex or helical flow, which is reflected by lower WSS and higher OSI.

DOI： 10.2463/mrms.mp.2019-0188

Web of Science

PubMed

2020年　最新医療機器の現状と展望　CTおよびMRIなどの画像診断装置の今後の在り方と展望 Reviewed

長縄慎二

月刊新医療データブック・シリーズ　医療機器システム白書 Vol. - ( - ) page： 12 - 15 2019.12

私と医療　New Med Essay ―第176回　動機はいい加減だったものの、真面目に取り組めばこそ― Reviewed

長縄慎二

月刊新医療 Vol. 540 ( - ) page： 77 - 77 2019.11

正常老化におけるTHK5351分布様式と安静時機能的ネットワークの関係性

吉田有佑, 横井孝政, 渡辺宏久, 山口博司, Bagarinao Epifanio, 桝田道人, 加藤隼康, 小倉礼, 大嶽れい子, 川畑和也, 原一洋, 勝野雅央, 加藤克彦, 長縄慎二, 岡村信行, 矢内一彦, 祖父江元

臨床神経学 Vol. 59 ( Suppl. ) page： S297 - S297 2019.11

Balloon-Occluded Retrograde Transvenous Obliteration for Fundal Gastric Variceal Bleeding in a Small Child. Reviewed International journal

Tomohiro Komada, Kojiro Suzuki, Kazuo Oshima, Masaya Matsushima, Ken Nagasaka, Shinji Naganawa

Journal of vascular and interventional radiology : JVIR Vol. 30 ( 10 ) page： 1624 - 1625 2019.10

ちょっと気になる胆・膵画像ティーチングファイルから(第43回) 術前診断が困難であった膵lymphangiomaの1例

小川浩, 竹原康雄, 長縄慎二, 高見秀樹, 中黒匡人

胆と膵 Vol. 40 ( 10 ) page： 841 - 844 2019.10

Glymphatic systemとMRI―ヒトでの可視化に向けた取り組み Reviewed

長縄慎二

医学のあゆみ Vol. 270 ( 13 ) page： 1189 - 1192 2019.10

Multi-window levels and widths imaging 画像変換による新たな読影手法の検討

伊藤倫太郎, 岩野信吾, 小田紘久, 森健策, 長縄慎二

日本医学放射線学会秋季臨床大会抄録集 Vol. 55回 page： S531 - S532 2019.9

Reorganization of brain networks and its association with general cognitive performance over the adult lifespan. Reviewed International journal

Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Toshiaki Taoka, Shuji Koyama, Hiroki C Tanabe, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Norio Ozaki, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Gen Sobue

Scientific reports Vol. 9 ( 1 ) page： 11352 - 11352 2019.8

Language：English Publishing type：Research paper (scientific journal)

Healthy aging is associated with structural and functional changes in the brain even in individuals who are free of neurodegenerative diseases. Using resting state functional magnetic resonance imaging data from a carefully selected cohort of participants, we examined cross sectional changes in the functional organization of several large-scale brain networks over the adult lifespan and its potential association with general cognitive performance. Converging results from multiple analyses at the voxel, node, and network levels showed widespread reorganization of functional brain networks with increasing age. Specifically, the primary processing (visual and sensorimotor) and visuospatial (dorsal attention) networks showed diminished network integrity, while the so-called core neurocognitive (executive control, salience, and default mode) and basal ganglia networks exhibited relatively preserved between-network connections. The visuospatial and precuneus networks also showed significantly more widespread increased connectivity with other networks. Graph analysis suggested that this reorganization progressed towards a more integrated network topology. General cognitive performance, assessed by Addenbrooke's Cognitive Examination-Revised total score, was positively correlated with between-network connectivity among the core neurocognitive and basal ganglia networks and the integrity of the primary processing and visuospatial networks. Mediation analyses further indicated that the observed association between aging and relative decline in cognitive performance could be mediated by changes in relevant functional connectivity measures. Overall, these findings provided further evidence supporting widespread age-related brain network reorganization and its potential association with general cognitive performance during healthy aging.

DOI： 10.1038/s41598-019-47922-x

Web of Science

PubMed

High-dose-rate intracavitary brachytherapy for recurrent cervical cancer in the vaginal stump after hysterectomy Reviewed Open Access

Kozai Yuka, Itoh Yoshiyuki, Kawamura Mariko, Nakahara Rie, Ito Junji, Okada Tohru, Kikkawa Fumitaka, Ikeda Mitsuru, Naganawa Shinji

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 81 ( 3 ) page： 351 - 358 2019.8

Language：English Publishing type：Research paper (scientific journal)

This study aimed to evaluate the treatment outcomes of patients who received high-dose-rate intracavitary brachytherapy (HDR-BT) using Iridium-192 with or without external beam radiotherapy as definitive treatment for recurrent cervical cancer after hysterectomy. Thirty-six patients with local recurrence after hysterectomy received radiotherapy including HDR-BT from 2005 to 2013. Overall survival, local control rate, and progression-free survival were estimated retrospectively via the Kaplan-Meier method. Late adverse events were also scored using the Common Terminology Criteria for Adverse Events (version 3.0). Median follow-up time was 38 (range, 7.4-101.3) months. The 3-year estimates of overall survival, local control rate, and progression-free survival were 100.0%, 82.8%, and 76.8%, respectively. Two patients (5.6%) had grade 2 lymphedema, but no other adverse events greater than grade 2 were reported. In conclusion, HDR-BT was an effective treatment modality for patients with cervical cancer recurrence in the vaginal stump.

DOI： 10.18999/nagjms.81.3.351

Open Access

Web of Science

PubMed

Whole abdominopelvic intensity-modulated radiation therapy for peritoneal disseminated rhabdomyosarcoma with three-year follow-up: a case report. Reviewed International journal

Mariko Kawamura, Kuniyasu Okudaira, Yoshiyuki Itoh, Takeshi Kamomae, Eri Nishikawa, Hideki Muramatsu, Yoshiyuki Takahashi, Kazuki Yokota, Shinji Naganawa

Radiation oncology (London, England) Vol. 14 ( 1 ) page： 127 - 127 2019.7

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The role of local radiotherapy in the treatment of metastatic rhabdomyosarcoma is important. However, with peritoneal dissemination, the application of local therapy is challenging. Although there are few reports addressing the efficacy of the whole abdominopelvic irradiation to peritoneal disseminated rhabdomyosarcoma patients, no precise curse of treatment nor the follow up result is explained in paper nor in the text. CASE PRESENTATION: Six years old rhabdomyosarcoma boy with peritoneal dissemination was treated at our facility under COG D9803 protocol (vincristine, dactinomycin, and cyclophosphamide (VAC)). He underwent tumor resection on the 14th week according to the protocol. During surgery, the 2-cm residual tumor was completely resected, but in the pelvis, numerous nodules that were suspected as peritoneal disseminated tumors were observed. We administered 30 Gy/20fr whole abdominopelvic radiotherapy using volumetric modulated arc therapy (VMAT) technique and a 6 Gy sequential boost to pelvis after the surgery and completed the protocol treatment. During the course of treatment, the patient experienced G4 hematological toxicity and received multiple transfusions, particularly after whole abdominopelvic irradiation. He has achieved complete remission and is alive without evidence of recurrence and severe late adverse effect for 3 years. In terms of growth, his height and weight are within the average values for Japanese boys at the same age. CONCLUSION: By using the VMAT technique, a patient with peritoneal disseminated rhabdomyosarcoma can be treated, and a dose of 30 Gy to the whole abdominopelvis with concurrent chemotherapy may be tolerable.

DOI： 10.1186/s13014-019-1333-x

Web of Science

PubMed

2.胸部領域　胸部画像診断におけるAIと臨床研究について Reviewed

伊藤倫太郎、岩野信吾、長縄慎二

INNERVISION Vol. 34 ( 7 ) page： 25 - 28 2019.7

Postoperative recurrence of clinical early-stage non-small cell lung cancers: a comparison between solid and subsolid nodules. Reviewed International journal

Shingo Iwano, Hiroyasu Umakoshi, Shinichiro Kamiya, Kohei Yokoi, Koji Kawaguchi, Takayuki Fukui, Shinji Naganawa

Cancer imaging : the official publication of the International Cancer Imaging Society Vol. 19 ( 1 ) page： 33 - 33 2019.6

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: For subsolid non-small cell lung cancers (NSCLCs), solid size (SS), which is the maximal diameter of the solid component, correlates more accurately with tumor prognosis than the total size, which is the maximal diameter of the entire tumor, including ground-glass opacity. We reviewed the propriety of the TNM staging based on the SS for early-stage NSCLCs. METHODS: We retrospectively reviewed the preoperative radiological reports, clinical records, and pathological reports of NSCLC cases in our hospital between 2010 and 2013, and clinical stage (c-Stage) 0 and I tumors were selected. Disease-free survival (DFS), based on survival analysis, was used to assess the tumor characteristics that predicted the prognosis. RESULTS: A total of 247 NSCLC diagnoses in 231 patients (88 women and 143 men; age, 67 ± 7 years) were included in our cohort. They were classified into solid (n = 131) and subsolid (n = 116) nodules. The DFS curves indicated that prognosis was significantly worse in the following order: c-Stage 0, c-Stage IA, and c-Stage IB tumors (p = 0.016). Patients with solid nodules showed a significantly worse prognosis than patients with subsolid nodules (p < 0.001). A multivariate Cox proportional hazards model showed that the significant predictive factors for DFS were c-Stage (hazard ratio, 1.600; p = 0.020) and solid nodules (hazard ratio, 3.077; p = 0.031). CONCLUSIONS: For early-stage NSCLCs, the c-Stage based on the SS in subsolid nodules was useful for predicting postoperative DFS. In addition, whether nodules were solid or subsolid was another independent prognostic factor.

DOI： 10.1186/s40644-019-0219-3

Web of Science

PubMed

Monitoring of fatigue in radiologists during prolonged image interpretation using fNIRS. Reviewed

Takashi Nihashi, Takeo Ishigaki, Hiroko Satake, Shinji Ito, Osamu Kaii, Yoshine Mori, Kazuhiro Shimamoto, Hiromichi Fukushima, Kojiro Suzuki, Hiroyasu Umakoshi, Mitsuo Ohashi, Fumio Kawaguchi, Shinji Naganawa

Japanese journal of radiology Vol. 37 ( 6 ) page： 437 - 448 2019.6

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To determine whether functional near-infrared spectroscopy (fNIRS) allows monitoring fatigue in radiologists during prolonged image interpretation. MATERIALS AND METHODS: Nine radiologists participated as subjects in the present study and continuously interpreted medical images and generated reports for cases for more than 4 h under real clinical work conditions. We measured changes in oxygenated hemoglobin concentrations [oxy-Hb] in the prefrontal cortex using 16-channel fNIRS (OEG16ME, Spectratech) every hour during the Stroop task to evaluate fatigue of radiologists and recorded fatigue scale (FS) as a behavior data. RESULTS: Two subjects showed a subjective feeling of fatigue and an apparent decrease in brain activity after 4 h, so the experiment was completed in 4 h. The remaining seven subjects continued the experiment up to 5 h. FS decreased with time, and a significant reduction was observed between before and the end of image interpretation. Seven out of nine subjects showed a minimum [oxy-Hb] change at the end of prolonged image interpretation. The mean change of [oxy-Hb] at the end of all nine subjects was significantly less than the maximum during image interpretation. CONCLUSION: fNIRS using the change of [oxy-Hb] may be useful for monitoring fatigue in radiologists during image interpretation.

DOI： 10.1007/s11604-019-00826-2

Web of Science

PubMed

食道平滑筋腫 Reviewed

兵藤良太、岩野信吾、長縄慎二

画像診断 Vol. 39 ( 7 ) page： 662 - 663 2019.6

【人工知能が医療を変える!医療分野におけるAI研究開発最前線2019】領域別・画像診断におけるAI研究開発の最前線胸部領域胸部画像診断におけるAIと臨床研究について

伊藤倫太郎, 岩野信吾, 長縄慎二

INNERVISION Vol. 34 ( 7 ) page： 25 - 28 2019.6

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(株)インナービジョン

2006年から始まった第三次AIブームによりAIの研究が加速度的に進み、現在ではスマートフォンのカメラや音声入力など身近なものに活用されている。放射線医学においては古くから人工知能(AI)を用いた研究が行われ、臨床にも応用されていた。最近では、さらに発展したAIを用いたCADの開発が盛んであり、世界中の研究者が開発を競っている。本稿では、加速度的に進歩するAIと放射線医学とのかかわりについて、主に胸部画像診断の観点から現在の状況と問題点についてまとめ、実際の研究例について提示する。(著者抄録)

Increased signal intensity of low-concentration gadolinium contrast agent by longer repetition time in heavily T<sub>2</sub>-weighted-3D-FLAIR.

Kato Y, Bokura K, Taoka T, Naganawa S

Japanese journal of radiology Vol. 37 ( 5 ) page： 431-435 2019.5

Phase II study of chemoradiotherapy combined with gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic ductal adenocarcinoma (NUPAT 05 Trial): study protocol for a single arm phase II study. Reviewed

Nao Takano, Suguru Yamada, Akihiro Hirakawa, Yukihiro Yokoyama, Hiroki Kawashima, Osamu Maeda, Tohru Okada, Eizaburo Ohno, Junpei Yamaguchi, Takuya Ishikawa, Fuminori Sonohara, Masaya Suenaga, Hideki Takami, Masamichi Hayashi, Yukiko Niwa, Yoshiki Hirooka, Yoshiyuki Ito, Shinji Naganawa, Yuichi Ando, Masato Nagino, Hidemi Goto, Tsutomu Fujii, Yasuhiro Kodera

Nagoya journal of medical science Vol. 81 ( 2 ) page： 233 - 239 2019.5

Language：English Publishing type：Research paper (scientific journal)

The efficacy of nab-paclitaxel combined with gemcitabine (GnP) and of chemoradiotherapy (CRT) for unresectable locally advanced pancreatic ductal adenocarcinoma (UR-LA PDAC) is still unclear. We previously conducted a phase I study of CRT using GnP and determined the recommended dose and have now designed a phase II trial to evaluate the efficacy of CRT incorporating GnP for UR-LA PDAC. Eligibility criteria are chemotherapy-naïve patients with UR-LA PDAC as defined by the NCCN guidelines version 2. 2016. Study patients will receive 100 mg/m2 nab-paclitaxel and 800 mg/m2 gemcitabine on Days 1, 8, and 15 per 4-week cycle with concurrent radiation therapy (total dose of 50.4 Gy in 28 fractions of 1.8 Gy per day, 5 days per week). Treatment will be continued until disease progression or surgery, which is to be performed only for patients in whom the disease is well-controlled at 8 months from beginning the protocol treatment. Primary endpoint is 2-year overall survival rate and co-primary endpoint is resection rate. Secondary endpoints are overall survival, progression free survival, time to treatment failure, response rate, disease control rate, early tumor shrinkage, depth of response, reduction of SUV-max on PET-CT, serum tumor markers, relative dose intensity, safety, and Quality of life. This study will show the efficacy and safety of chemoradiotherapy combined with GnP.

DOI： 10.18999/nagjms.81.2.233

Web of Science

PubMed

子宮平滑筋肉腫 Reviewed

櫻井悠介、岩野信吾、長縄慎二、下山芳江、新美　薫

画像診断 Vol. 39 ( 6 ) page： 512 - 513 2019.5

画像診断と病理食道平滑筋腫

兵藤良太, 岩野信吾, 長縄慎二, 宮田一志, 島田聡子

画像診断 Vol. 39 ( 7 ) page： 662 - 663 2019.5

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Papers - NAGANAWA, Shinji