Faculty Profiles - NAGANAWA, Shinji

Papers - NAGANAWA, Shinji

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Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases. Reviewed

Toshiaki Taoka, Yoshitaka Masutani, Hisashi Kawai, Toshiki Nakane, Kiwamu Matsuoka, Fumihiko Yasuno, Toshifumi Kishimoto, Shinji Naganawa

Japanese journal of radiology Vol. 35 ( 4 ) page： 172 - 178 2017.4

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: The activity of the glymphatic system is impaired in animal models of Alzheimer's disease (AD). We evaluated the activity of the human glymphatic system in cases of AD with a diffusion-based technique called diffusion tensor image analysis along the perivascular space (DTI-ALPS). MATERIALS AND METHODS: Diffusion tensor images were acquired to calculate diffusivities in the x, y, and z axes of the plane of the lateral ventricle body in 31 patients. We evaluated the diffusivity along the perivascular spaces as well as projection fibers and association fibers separately, to acquire an index for diffusivity along the perivascular space (ALPS-index) and correlated them with the mini mental state examinations (MMSE) score. RESULTS: We found a significant negative correlation between diffusivity along the projection fibers and association fibers. We also observed a significant positive correlation between diffusivity along perivascular spaces shown as ALPS-index and the MMSE score, indicating lower water diffusivity along the perivascular space in relation to AD severity. CONCLUSION: Activity of the glymphatic system may be evaluated with diffusion images. Lower diffusivity along the perivascular space on DTI-APLS seems to reflect impairment of the glymphatic system. This method may be useful for evaluating the activity of the glymphatic system.

DOI： 10.1007/s11604-017-0617-z

Web of Science

PubMed

Magnetic resonance imaging evaluation of endolymphatic hydrops andpost-operative findings in cases with otosclerosis.

Michihiko Sone, Tadao Yoshida, Satofumi Sugimoto, Kyoko Morimoto, Yuriko Okazaki, Masaaki Teranishi, Shinji Naganawa, Tsutomu Nakashima

Acta Otolaryngol. Vol. 137 ( 3 ) page： 242-245 2017.3

Do gadolinium-based contrast agents affect the 18F-FDG PET/CT uptake in the dentate nucleus and the globus pallidus? Reviewed

Shinji Naganawa

J Nucl Med Technol. 2017.3

Modulation of immunological activity on macrophages induced by diazinon Reviewed

Nanako Ogasawara, Miyoko Matsushima, Nami Kawamura, Kazuko Atsumi, Takehiro Yamaguchi, Haruka Ochi, Yuto Kusatsugu, Sayaka Oyabu, Naozumi Hashimoto, Yoshinori Hasegawa, Jun Ueyama, Tsutomu Kawabe

TOXICOLOGY Vol. 379 page： 22 - 30 2017.3

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER IRELAND LTD

Diazinon is an organophosphorus (OP) insecticide and is widely used not only in agriculture but also homes and garden in Japan. Diazinon has been reported to increase TNF-alpha production in rat serum and brain, suggesting that it can modify the proinflammatory response. In this study, we investigated the effects of diazinon on macrophage functions, such as cytokine production, reactive oxygen species (ROS) generation, cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) expressions, cell-surface molecule expressions, and phagocytosis in RAW264.7 cells. In RAW264.7 cells, diazinon induced the production of TNF-alpha and IL-6. Diazinon induced ROS generation and the expressions of COX-2, iNOS, and cell-surface molecules CD40, CD86, and MI-IC class II, but reduced phagocytic activity in RAW264.7 cells. ERIC and p38, but not JNK and p65 were involved in diazinon-induced IL-6 expression in RAW264.7 cells. We also examined these proinflammatory responses in bone marrow-derived macrophages (BMDM) and bronchoalveolar lavage fluid (BALF) cells. These results suggested that diazinon can activate macrophages and enhance inflammatory responses. (C) 2017 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.tox.2017.01.014

Web of Science

Scopus

Other Link： http://orcid.org/0000-0003-0660-2726

Emerging neuroradiological topics in journals from related societies. Reviewed

Yukunori Korogi, Shinji Naganawa

Jpn. J Radiol. Vol. 35 ( 1 ) page： 1-2 2017.2

Postoperative chemoradiation therapy using high dose cisplatin and fluorouracil for high- and intermediate-risk uterine cervical cancer. Reviewed

Rise Miyauchi, Yoshiyuki Itoh, Mariko Kawamura, Akihiro Hirakawa, Kiyosumi Shibata, Hiroaki Kajiyama, Rie Nakahara, Seiji Kubota, Junji Ito, Tohru Okada, Fumitaka Kikkawa, Shinji Naganawa

Nagoya J Med Sci. Vol. 79 ( 2 ) page： 211-220 2017.2

Imaging of the endolymphatic space in patients with Ménière's disease. Reviewed

Tadao Yoshida, Satofumi Sugimoto, Masaaki Teranishi, Hironao Otake, Masahiro Yamazaki, Shinji Naganawa, Tsutomu Nakashima, Michihiko Sone

Auris Nasus Larynx. ( 17 ) page： 30142-6 2017.2

Dual Energy CTによる小型肺癌の造影評価

島本宏矩, 岩野信吾, 馬越弘泰, 伊藤倫太郎, 長縄慎二

Japanese Journal of Radiology Vol. 35 ( Suppl. ) page： 34 - 34 2017.2

胸壁並行断面CTを用いた間質性肺炎の定量的評価

馬越弘泰, 岩野信吾, 伊藤倫太郎, 長縄慎二

Japanese Journal of Radiology Vol. 35 ( Suppl. ) page： 34 - 34 2017.2

ドパミントランスポータシンチグラフィにおける解析ソフトの有用性に関する研究

松澤伸一郎, 加藤克彦, 国本啓太, 本田将之, 椋本竜斗, 小田川哲郎, 阿部真治, 藤田尚利, 櫻木庸博, 伊藤信嗣, 伊藤倫太郎, 岩野信吾, 長縄慎二

核医学 Vol. 54 ( 1 ) page： 663 - 663 2017.2

FDG-PETによる非小細胞肺癌の予後予測因子の検討 SUVmaxと体積を考慮した指標の比較

伊藤信嗣, 岩野信吾, 伊藤倫太郎, 長縄慎二, 加藤克彦

核医学 Vol. 54 ( 1 ) page： 565 - 565 2017.2

Endolymphatic hydrops in patients with unilateral and bilateral Meniere's disease.

Kyoko Morimoto, Tadao Yoshida, Saiko Sugiura, Masahiro Kato, Ken Kato, Masaaki Teranishi, Shinji Naganawa, Tsutomu Nakashima, Michihiko Sone

Acta Otolaryngol. Vol. 137 ( 1 ) page： 23-28 2017.1

Structure of the Medullary Veins of the Cerebral Hemisphere and Related Disorders. Reviewed

Toshiaki Taoka, Akio Fukuisumi, Toshiteru Miyasaka, Hisashi Kawai, Toshiki Nakane, Kimihiko Kichikawa, Shinji Naganawa

Radiographics. Vol. 37 ( 1 ) page： 281-297 2017.1

Visualization of Middle Ear Ossicles in Elder Subjects with Ultra-short Echo Time MR Imaging

Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka, Kojiro Suzuki, Shingo Iwano, Hiroko Satake, David Grodzki

MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 16 ( 2 ) page： 93 - 97 2017

Language：English Publishing type：Research paper (scientific journal) Publisher：JPN SOC MAGNETIC RESONANCE MEDICINE

Purpose: To evaluate the visualization of middle ear ossicles by ultra-short echo time magnetic resonance (MR) imaging at 3T in subjects over 50 years old.
Materials and Methods: Sixty ears from 30 elder patients that underwent surgical or interventional treatment for neurovascular diseases were included (ages: 50-82, median age: 65; 10 men, 20 women). Patients received follow-up MR imaging including routine T1-and T2-weighted images, time-of-flight MR angiography, and ultra-short echo time imaging (PETRA, pointwise encoding time reduction with radial acquisition). All patients underwent computed tomography (CT) angiography before treatment. Thin-section source CT images were correlated with PETRA images. Scan parameters for PETRA were: TR 3.13, TE 0.07, flip angle 6 degrees, 0.83 x 0.83 x 0.83 mm resolution, 3 min 43 s scan time. Two radiologists retrospectively evaluated the visibility of each ossicular structure as positive or negative using PETRA images. The structures evaluated included the head of the malleus, manubrium of the malleus, body of the incus, long process of the incus, and the stapes. Signal intensity of the ossicles was classified as: between labyrinthine fluid and air, similar to labyrinthine fluid, between labyrinthine fluid and cerebellar parenchyma, or higher than cerebellar parenchyma.
Results: In all ears, the body of the incus was visible. The head of the malleus was visualized in 36/60 ears. The manubrium of the malleus and long process of the incus was visualized in 1/60 and 4/60 ears, respectively. The stapes were not visualized in any ear. Signal intensity of the visible structures was between labyrinthine fluid and air in all ears.
Conclusion: The body of the incus was consistently visualized with intensity between air and labyrinthine fluid on PETRA images in aged subjects. Poor visualization of the manubrium of the malleus, long process of the incus, and the stapes limits clinical significance of middle ear imaging with current PETRA methods.

DOI： 10.2463/mrms.mp.2015-0171

Web of Science

PubMed

Gd-based Contrast Enhancement of the Perivascular Spaces in the Basal Ganglia

Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka

MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 16 ( 1 ) page： 61 - 65 2017

Language：English Publishing type：Research paper (scientific journal) Publisher：JPN SOC MAGNETIC RESONANCE IN MEDICINE

Purpose: In textbooks, the perivascular space (PVS) is described as non-enhancing after the intravenous administration of gadolinium-based contrast agent (IV-GBCA). We noticed that the PVS sometimes has high signal intensity (SI) on heavily T-2-weighted 3D-FLAIR (hT(2)-FL) images obtained 4 h after IV-GBCA. The purpose of this study was to retrospectively evaluate the contrast enhancement of the PVS.
Materials and Methods: In 8 healthy subjects and 19 patients with suspected endolymphatic hydrops, magnetic resonance cisternography (MRC) and hT(2)-FL images were obtained before and 4 h after a single dose of IV-GBCA. No subjects had renal insufficiency. On axial MRC at the level of the anterior commissure (AC)-posterior commissure (PC) line, 1 cm circular regions of interest (ROIs) were drawn centering on the PVS in the bilateral basal ganglia and thalami. Three-millimeter diameter ROIs were set in the cerebrospinal fluid (CSF) of the bilateral ambient cistern. The ROIs on MRC were copied onto the hT2-FL images and the SI was measured. The SI ratio (SIR) was defined as SIRPVS = SI of PVS/SI of the thalami, and SIRCSF = SI of CSF/SI of the thalami. The average of the bilateral values was used for the calculation. The SIRCSF, SIRPVS, and SI of the thalami were compared between before and 4 h after IV-GBCA.
Results: The SIR was increased significantly from 1.02 +/- 0.37 to 2.65 +/- 0.82 in the CSF (P < 0.01) and from 1.20 +/- 0.35 to 2.13 +/- 1.23 in the PVS at 4 h after IV-GBCA (P < 0.01). The SI of the thalami showed no significant difference.
Conclusion: The enhancement of the PVS at 4 h after IV-GBCA was confirmed even in subjects without renal insufficiency. It is possible that the GBCA in the blood vessels might have permeated into the cerebrospinal fluid (CSF) space and the PVS. This might be a first step in the imaging evaluation of the glymphatic system (waste clearance system) of the brain.

DOI： 10.2463/mrms.mp.2016-0039

Web of Science

PubMed

Detection of endolymphatic hydrops using traditional MR imaging sequences

Naganawa Shinji, Sone Michihiko

AMERICAN JOURNAL OF OTOLARYNGOLOGY Vol. 38 ( 5 ) page： 637-638 2017

Quantitative evaluation of interstitial pneumonia using 3D-curved high-resolution CT imaging parallel to the chest wall: A pilot study. Reviewed International journal

Hiroyasu Umakoshi, Shingo Iwano, Tsutomu Inoue, Yuanzhong Li, Shinji Naganawa

PloS one Vol. 12 ( 9 ) page： e0185532 2017

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: To quantify the imaging findings of patients with interstitial pneumonia (IP) and emphysema using three-dimensional curved high-resolution computed tomography (3D-cHRCT) at a constant depth from the chest wall, and compare the results to visual assessment of IP and each patient's diffusing capacity of the lungs for carbon monoxide (DLco). METHODS: We retrospectively reviewed the axial CT findings and pulmonary function test results of 95 patients with lung cancer (72 men and 23 women, aged 45-84 years) with or without IP, as follows: non-IP (n = 47), mild IP (n = 31), and moderate IP (n = 17). The 3D-cHRCT images of the lung at a 1-cm depth from the chest wall were reconstructed automatically using original software; total area (TA), high-attenuation area (HAA) >-500 HU, and low-attenuation area (LAA) <-950 HU were calculated on a workstation. The %HAA and %LAA were calculated as follows: [Formula: see text], and [Formula: see text]. RESULTS: The %HAA and %LAA respective values were 3.2±0.9 and 27.7±8.2, 3.9±1.2 and 27.6±5.9, and 6.9±2.2 and 25.4±8.7 in non-IP, mild IP, and moderate IP patients, respectively. There were significant differences in %HAA between the 3 groups of patients (P<0.001), but no differences in %LAA (P = 0.558). Multiple linear regression analysis revealed that %HAA and %LAA were negatively correlated with predicted DLco (standard partial regression coefficient [b*] = -0.453, P<0.001; b* = -0.447, P<0.001, respectively). CONCLUSIONS: The %HAA and %LAA values computed using 3D-cHRCT were significantly correlated with DLco and may be important quantitative parameters for both IP and emphysema.

DOI： 10.1371/journal.pone.0185532

Web of Science

PubMed

Thoracic Temporal Subtraction Three Dimensional Computed Tomography (3D-CT): Screening for Vertebral Metastases of Primary Lung Cancers. Reviewed International journal

Shingo Iwano, Rintaro Ito, Hiroyasu Umakoshi, Takatoshi Karino, Tsutomu Inoue, Yuanzhong Li, Shinji Naganawa

PloS one Vol. 12 ( 1 ) page： e0170309 2017

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: We developed an original, computer-aided diagnosis (CAD) software that subtracts the initial thoracic vertebral three-dimensional computed tomography (3D-CT) image from the follow-up 3D-CT image. The aim of this study was to investigate the efficacy of this CAD software during screening for vertebral metastases on follow-up CT images of primary lung cancer patients. MATERIALS AND METHODS: The interpretation experiment included 30 sets of follow-up CT scans in primary lung cancer patients and was performed by two readers (readers A and B), who each had 2.5 years' experience reading CT images. In 395 vertebrae from C6 to L3, 46 vertebral metastases were identified as follows: osteolytic metastases (n = 17), osteoblastic metastases (n = 14), combined osteolytic and osteoblastic metastases (n = 6), and pathological fractures (n = 9). Thirty-six lesions were in the anterior component (vertebral body), and 10 lesions were in the posterior component (vertebral arch, transverse process, and spinous process). The area under the curve (AUC) by receiver operating characteristic (ROC) curve analysis and the sensitivity and specificity for detecting vertebral metastases were compared with and without CAD for each observer. RESULTS: Reader A detected 47 abnormalities on CT images without CAD, and 33 of them were true-positive metastatic lesions. Using CAD, reader A detected 57 abnormalities, and 38 were true positives. The sensitivity increased from 0.717 to 0.826, and on ROC curve analysis, AUC with CAD was significantly higher than that without CAD (0.849 vs. 0.902, p = 0.021). Reader B detected 40 abnormalities on CT images without CAD, and 36 of them were true-positive metastatic lesions. Using CAD, reader B detected 44 abnormalities, and 39 were true positives. The sensitivity increased from 0.783 to 0.848, and AUC with CAD was nonsignificantly higher than that without CAD (0.889 vs. 0.910, p = 0.341). Both readers detected more osteolytic and osteoblastic metastases with CAD than without CAD. CONCLUSION: Our temporal 3D-CT subtraction CAD software easily detected vertebral metastases on the follow-up CT images of lung cancer patients regardless of the osteolytic or osteoblastic nature of the lesions.

DOI： 10.1371/journal.pone.0170309

Web of Science

PubMed

CSF Pulsation Artifacts on ADC Maps Obtained with Readout-segmented EPI

Ohashi Toshio, Naganawa Shinji, Kanou Mai, Ikeda Mitsuru

MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 16 ( 2 ) page： 123-128 2017

A multicenter survey of stage T1 glottic cancer treated with radiotherapy delivered in 2.25-Gy fractions in clinical practice: An initial 5-year analysis.

Yoshiyuki Itoh, Seiji Kubota, Mariko Kawamura, Yoshihito Nomoto, Takayuki Murao, Kouji Yamakawa, Shunichi Ishihara, Naoki Hirasawa, Akiko Asano, Shigeo Yanagawa, Shinji Naganawa

Nagoya J. Med. Sci. Vol. 78 ( 4 ) page： 399-406 2016.12

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Papers - NAGANAWA, Shinji