Faculty Profiles - NAGANAWA, Shinji

Papers - NAGANAWA, Shinji

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Improved 3D-real Inversion Recovery: A Robust Imaging Technique for Endolymphatic Hydrops after Intravenous Administration of Gadolinium.

Naganawa S, Kawai H, Taoka T, Sone M

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 2018.3

Distinct manifestation of cognitive deficits associate with different resting-state network disruptions in non-demented patients with Parkinson's disease.

Kawabata K, Watanabe H, Hara K, Bagarinao E, Yoneyama N, Ogura A, Imai K, Masuda M, Yokoi T, Ohdake R, Tanaka Y, Tsuboi T, Nakamura T, Hirayama M, Ito M, Atsuta N, Maesawa S, Naganawa S, Katsuno M, Sobue G

Journal of neurology Vol. 265 ( 3 ) page： 688-700 2018.3

Distinct manifestation of cognitive deficits associate with different resting-state network disruptions in non-demented patients with Parkinson's disease

Kawabata Kazuya, Watanabe Hirohisa, Hara Kazuhiro, Bagarinao Epifanio, Yoneyama Noritaka, Ogura Aya, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ohdake Reiko, Tanaka Yasuhiro, Tsuboi Takashi, Nakamura Tomohiko, Hirayama Masaaki, Ito Mizuki, Atsuta Naoki, Maesawa Satoshi, Naganawa Shinji, Katsuno Masahisa, Sobue Gen

JOURNAL OF NEUROLOGY Vol. 265 ( 3 ) page： 688-700 2018.3

特集　脳脊髄液動態のすべて　脳脊髄液による老廃物のクリアランス―glymphaticシステム―

田岡俊昭、長縄慎二

画像診断 Vol. 38 ( 3 ) page： 268-276 2018.3

MR画像による脳内の物質輸送機構の解明

長縄慎二、田岡俊昭、川井　恒

脳とこころの研究センター　脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成　　　平成29年度活動報告書 page： 25-26 2018.3

脳とこころの研究センター長　挨拶

長縄慎二

脳とこころの研究センター　脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成　　　平成29年度活動報告書 page： 1 2018.3

後下小脳動脈抹消部動脈瘤の診断におけるthin slab MIP法の有用性

長縄慎二

日本脳神経CI学会機関誌 Vol. 39 ( 3-4 ) page： 121-130 2018.3

Patients with anti-thyroid antibodies are prone to develop destructive thyroiditis by nivolumab: a prospective study Reviewed

Tomoko Kobayashi, Shintaro Iwama, Yoshinori Yasuda, Norio Okada, Taku Tsunekawa, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Yoshihiro Ito, Yoshiaki Morishita, Motomitsu Goto, Hidetaka Suga, Ryoichi Banno, Kenji Yokota, Tetsunari Hase, Masahiro Morise, Naozumi Hashimoto, Masahiko Ando, Hitoshi Kiyoi, Momokazu Gotoh, Yuichi Ando, Masashi Akiyama, Yoshinori Hasegawa, Hiroshi Arima

Journal of the Endocrine Society 2018.2

Detecting sub-second changes in brain activation patterns during interictal epileptic spike using simultaneous EEG-fMRI. Reviewed International journal

Epifanio Bagarinao, Satoshi Maesawa, Yuji Ito, Naotaka Usui, Jun Natsume, Hirohisa Watanabe, Minoru Hoshiyama, Toshihiko Wakabayashi, Gen Sobue, Shinji Naganawa, Haruo Isoda

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Vol. 129 ( 2 ) page： 377 - 389 2018.2

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Epileptic spikes are associated with rapidly changing brain activation involving the epileptic foci and other brain regions in the "epileptic network". We aim to resolve these activation changes using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) recordings. METHODS: Simultaneous EEG-fMRI recordings from 9 patients with epilepsy were used in the analysis. Our method employed the whole scalp EEG data to generate regressors for the analysis of fMRI data using the general linear model. RESULTS: We were able to resolve, with milliseconds temporal resolution, changes in activation patterns involving suspected epileptic foci and other brain regions in the epileptic network during spike and slow wave. Using summary maps (called SSWAS maps) which show the activation frequency of voxels, we found that suspected epileptic foci tend to be significantly active during this interval. SSWAS maps also enabled the detection of the epileptic foci in 4 of 5 patients where the conventional event-timing-based analysis failed to identify. CONCLUSION: These findings demonstrated the efficacy of the method and the potential application of SSWAS maps to identify epileptic foci. SIGNIFICANCE: The method could help resolve activation changes during epileptic spike and could provide insights into the underlying pathophysiology of these changes.

DOI： 10.1016/j.clinph.2017.11.018

Web of Science

PubMed

Imaging of the endolymphatic space in patients with Ménière's disease. Reviewed International journal

Tadao Yoshida, Satofumi Sugimoto, Masaaki Teranishi, Hironao Otake, Masahiro Yamazaki, Shinji Naganawa, Tsutomu Nakashima, Michihiko Sone

Auris, nasus, larynx Vol. 45 ( 1 ) page： 33 - 38 2018.2

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To examine endolymphatic hydrops (EH) using magnetic resonance imaging (MRI) in patients with definite Ménière's disease (MD) and those with nonotological diseases. METHODS: We studied 32 patients with unilateral MD, 10 patients with bilateral MD and 21 patients with control ears who had other benign diseases not associated with hearing or vestibular dysfunction. The mean age of the subjects was 54.0 years (range 27-74) in the MD group and 56.1 years (range 24-79) in the control group. Using MRI, the degree of EH was classified as none, mild and significant in the cochlea and vestibule separately. The ratio of the area of endolymphatic space to the vestibular fluid space was calculated for the vestibule. The duration of MD was defined as the months between the first attack of MD and the MRI study. RESULTS: EH was present in the cochlea of 45/52 affected ears of patients with MD (87%) and in 16/42 control ears (38%). Significant cochlear hydrops was present in 37/52 affected ears (71%) and in 4/42 control ears (10%). EH in the vestibule was present in 49/52 affected ears (94%) and in 3/42 control ears (7%). Significant vestibular hydrops was present in 40/52 affected ears (77%) and in none of the 42 control ears. There was no relationship between the degree of EH and its duration. Using a cut off value for the relative size of EH in the vestibule of 41.9%, the test had a sensitivity of 88.5% and a specificity of 100% to diagnose definite MD. CONCLUSION: Cochlear EH was occasionally observed in control ears on MRI, as in normal temporal bone specimens. The presence or absence and degree of vestibular EH were significantly different between ears with MD and control ears. EH in the vestibule might be a specific predictor of definite MD.

DOI： 10.1016/j.anl.2017.02.002

Web of Science

PubMed

早期声門癌に対するS-1併用化学放射線療法の長期成績

高瀬裕樹, 伊藤善之, 木村香菜, 岡田徹, 久保田誠司, 川村麻里子, 中原理絵, 大家祐実, 香西由加, 長縄慎二, 藤本保志, 曾根三千彦

Japanese Journal of Radiology Vol. 36 ( Suppl. ) page： 22 - 22 2018.2

胸壁並行断面CTを用いた間質性肺炎の経時的評価

馬越弘泰, 岩野信吾, 伊藤倫太郎, 島本宏矩, 長縄慎二

Japanese Journal of Radiology Vol. 36 ( Suppl. ) page： 19 - 19 2018.2

非小細胞肺癌の局所浸潤性の予測に関する造影dual energy CTとFDG-PET/CTの比較

伊藤倫太郎, 岩野信吾, 島本宏矩, 馬越弘泰, 伊藤信嗣, 長縄慎二, 加藤克彦

Japanese Journal of Radiology Vol. 36 ( Suppl. ) page： 20 - 20 2018.2

【脳脊髄液動態のすべて】脳脊髄液による老廃物のクリアランス glymphaticシステム

田岡俊昭, 長縄慎二

画像診断 Vol. 38 ( 3 ) page： 268 - 276 2018.2

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(株)Gakken

glymphaticシステムは頭蓋内の脳脊髄液,脳内の間質液を含む循環に関連した1つのコンセプトであり,脳実質内の老廃物を洗い出すシステムとして広く受け入れられるようになりつつある.その一方で,以前から提唱されている細小動脈壁の排出路を介したシステムとの関連も含めて,この仮説に関して不明な点も多く,現時点で多くの議論がある.(著者抄録)

Other Link： https://search.jamas.or.jp/default/link?pub_year=2018&ichushi_jid=J00235&link_issn=&doc_id=20180226160007&doc_link_id=10.15105%2FGZ.0000000353&url=https%3A%2F%2Fdoi.org%2F10.15105%2FGZ.0000000353&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

Relationship between Contrast Enhancement of the Perivascular Space in the Basal Ganglia and Endolymphatic Volume Ratio. Reviewed

Toshio Ohashi, Shinji Naganawa, Toshio Katagiri, Kayao Kuno

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine Vol. 17 ( 1 ) page： 67 - 72 2018.1

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: We routinely obtain the endolymphatic hydrops (EH) image using heavily T2-weighted three dimensional-fluid attenuated inversion recovery (hT2w-3D-FLAIR) imaging at 4 hours after intravenous administration of a single-dose of gadolinium-based contrast media (IV-SD-GBCM). While repeating the examination, we speculated that the contrast enhancement of the perivascular space (PVS) in the basal ganglia might be related to the degree of EH. Therefore, the purpose of this study was to investigate the relationship between the endolymphatic volume ratio (%ELvolume) and the signal intensity of the PVS (SI-PVS). MATERIALS AND METHODS: In 20 patients with a suspicion of EH, a heavily T2-weighted 3D-turbo spin echo sequence for MR cisternography (MRC) and an hT2w-3D-FLAIR as a positive perilymph image (PPI) were obtained at 4 hours after IV-SD-GBCM. The %ELvolume of the cochlea and the vestibule were measured on the previously reported HYDROPS2-Mi2 image. The PVS in the basal ganglia was segmented on MRC using a region-growing method. The PVS regions were copied and pasted onto the PPI, and the SI-PVS was measured. The larger value of the right and the left ears was employed as the %ELvolume, and the weighted average of both sides was employed as the SI-PVS. The correlation between the %ELvolume and the SI-PVS was evaluated. RESULT: There was a strong negative linear correlation between the %ELvolume of the cochlea and the SI-PVS (r = -0.743, P < 0.001); however, there was no significant correlation between the %ELvolume of the vestibule and the SI-PVS (r = -0.267, P = 0.256). CONCLUSION: There was a strong negative correlation between the cochlear %ELvolume and the SI-PVS. Contrast enhancement of PVS might be a biomarker of EH.

DOI： 10.2463/mrms.mp.2017-0001

Web of Science

PubMed

Gadolinium-based Contrast Media, Cerebrospinal Fluid and the Glymphatic System: Possible Mechanisms for the Deposition of Gadolinium in the Brain. Reviewed

Toshiaki Taoka, Shinji Naganawa

Magn Reson Med Sci. 2018.1

Differences in Signal Intensity and Enhancement on MR Images of the Perivascular Spaces in the Basal Ganglia versus Those in White Matter

Naganawa Shinji, Nakane Toshiki, Kawai Hisashi, Taoka Toshiaki

MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 17 ( 4 ) page： 301-307 2018

Clinical MR imaging of endolymphatic hydrops: Updates on scanning methods, image processing and interpretation. Reviewed

Shinji Naganwa

Solutions in Contrast Imaging. Vol. 9 ( 5 ) page： 1-5 2018

An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan. Reviewed

Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Toshihiko Wakabayashi, Masafumi Kuzuya, NorioOzaki, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Gen Sobue

Neuroimage ( 169 ) page： 134-144 2017.12

Longitudinal up-regulation of endolymphatic hydrops in patients with Meniere's disease during medical treatment. Reviewed International journal

Munehisa Fukushima, Tadashi Kitahara, Ryohei Oya, Shiro Akahani, Hidenori Inohara, Shinji Naganawa, Noriaki Takeda

Laryngoscope investigative otolaryngology Vol. 2 ( 6 ) page： 344 - 350 2017.12

Language：English Publishing type：Research paper (scientific journal)

Objective/Hypothesis: Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments. Study Design: Prospective, single-arm repeated measures. Methods: Eleven MD patients were enrolled. All subjects prospectively underwent gadolinium-enhanced inner ear magnetic resonance (MR) imaging and neuro-otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months. Results: The frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13-91% of the pre-treatment level. The volume ratio of post-treatment EH-to-pre-treatment EH ranged from 1.01-3.22. The total volume of pre-treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level. Conclusion: EH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period. Level of Evidence: 2b.

DOI： 10.1002/lio2.115

Web of Science

PubMed

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Papers - NAGANAWA, Shinji