Faculty Profiles - NAGANAWA, Shinji

Papers - NAGANAWA, Shinji

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7テスラMR装置における高空間分解能3次元位相コントラスト磁気共鳴法を利用した脳血流動態解析の制度検証 Reviewed

田嶋駿亮、礒田治夫、福永雅喜、長縄慎二

脳とこころの研究センター脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成平成30年度活動報告書 Vol. - ( - ) page： 24 - 24 2019.3

腎静脈に発生した平滑筋肉腫 Invited Reviewed

松島正哉、林　葉子、岩野信吾、長縄慎二、下山芳江

画像診断 Vol. 39 ( 3 ) page： 252 - 253 2019.3

脳とこころの研究センター長　挨拶 Reviewed

長縄慎二

脳とこころの研究センター脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成平成30年度活動報告書 Vol. - ( - ) page： 1 - 1 2019.3

MRによる血液-脳間質液-脳脊髄液の動態の解明 Reviewed

長縄慎二、田岡俊昭、川井　恒

脳とこころの研究センター脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成平成30年度活動報告書 Vol. - ( - ) page： 29 - 30 2019.3

Quantitative Follow-Up Assessment of Patients with Interstitial Lung Disease by 3D-Curved High-Resolution CT Imaging Parallel to the Chest Wall. Reviewed Open Access

Hiroyasu Umakoshi, Shingo Iwano, Tsutomu Inoue, Yuanzhong Li, Keigo Nakamura, Shinji Naganawa

Nagoya journal of medical science Vol. 81 ( 1 ) page： 41 - 53 2019.2

Language：English Publishing type：Research paper (scientific journal)

We evaluated the progression of interstitial lung disease (ILD) by three-dimensional curved high-resolution computed tomography (3D-cHRCT) at a constant depth from the chest wall and compare the results to pulmonary function test (PFT) results on a follow-up assessment. We reviewed the patients with ILD who underwent HRCT and concurrent PFTs at least twice from April 2008 to December 2014. Forty-five patients with ILD were enrolled. 3D-cHRCT images of the lung at various depths from the chest wall were reconstructed, and total area (TA), high-attenuation area (HAA) >-500 HU, and %HAA ([HAA/TA] × 100) were calculated. The TA, HAA, and %HAA ratios (follow-up to baseline) were assessed for use in the diagnosis of physiologically progressive ILD (defined as; forced vital capacity [FVC] ratio <0.9 or %diffusing capacity of the lung for carbon monoxide [%DLCO] ratio <0.85 [follow-up to baseline]). Of all ratios obtained from 3D-cHRCT images at 5-30mm depths, the %HAA ratio at 20-mm had the largest area under the receiver operating characteristic curve (0.815, 95 % confidence interval 0.677-0.953). By univariate logistic regression analysis, TA, HAA, and %HAA ratios at 20-mm showed significant correlations with physiologically progressive ILD. 3D-cHRCT imaging performed in parallel with the chest wall offers novel quantitative parameters that are useful for following ILD.

DOI： 10.18999/nagjms.81.1.41

Open Access

Web of Science

PubMed

パーキンソン病におけるdefault mode network Reviewed

渡辺宏久、勝野雅央、長縄慎二、祖父江元

CLINICAL NEUROSCIENCE (月間　臨床神経科学) Vol. 37 ( 2 ) page： 212 - 216 2019.2

膵上皮内腫瘍性病変 Reviewed

小川　浩、岩野信吾、長縄慎二、中黒匡人

画像診断 Vol. 39 ( 2 ) page： 142 - 143 2019.2

原発性肺癌の術前臨床病期診断の正確性

岩野信吾, 馬越弘泰, 伊藤倫太郎, 島本宏矩, 長縄慎二

Japanese Journal of Radiology Vol. 37 ( Suppl. ) page： 25 - 25 2019.2

イピリムマブに伴う下垂体炎の3例

加藤理恵子, 川井恒, 田岡俊昭, 長縄慎二, 岩間信太郎

Japanese Journal of Radiology Vol. 37 ( Suppl. ) page： 25 - 25 2019.2

Significance of internal auditory canal diverticula in ears with otosclerosis. Open Access

Wang F, Yoshida T, Shimono M, Sugimoto S, Teranishi M, Naganawa S, Sone M

Acta oto-laryngologica page： 1-4 2019.1

画像診断と病理骨芽細胞腫

駒田智大, 岩野信吾, 長縄慎二, 新井英介, 西田佳弘, 下山芳江

画像診断 Vol. 39 ( 1 ) page： 4-5 - 5 2018.12

Signal Intensity of the Cerebrospinal Fluid after Intravenous Administration of Gadolinium-based Contrast Agents: Strong Contrast Enhancement around the Vein of Labbe. Open Access

Ohashi T, Naganawa S, Ogawa E, Katagiri T, Kuno K

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 2018.11

Can low b value diffusion weighted imaging evaluate the character of cerebrospinal fluid dynamics?

Taoka T, Naganawa S, Kawai H, Nakane T, Murata K

Japanese journal of radiology 2018.11

Age Dependence of Gadolinium Leakage from the Cortical Veins into the Cerebrospinal Fluid Assessed with Whole Brain 3D-real Inversion Recovery MR Imaging. Open Access

Naganawa S, Nakane T, Kawai H, Taoka T

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 2018.11

2019年　最新医療機器の動向を探る　CTおよびMRIなどの画像診断機器の最新潮流ならびに今後のあり方

長縄慎二

医療機器システム白書 page： 14-17 2018.11

Analysis of late adverse events and their chronological changes after radiation therapy for cervical cancer Open Access

Yamada Takehiro, Ishihara Shunichi, Kawai Michiyasu, Itoh Yoshiyuki, Naganawa Shinji, Ikeda Mitsuru

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 80 ( 4 ) page： 487-496 2018.11

画像診断レポート未読問題について Reviewed

長縄慎二

健康文化 Vol. 53 ( - ) page： 138 - 142 2018.11

第三次人工知能ブーム？ Reviewed

長縄慎二

健康文化 Vol. 53 ( - ) page： 1 - 2 2018.11

Significance of Endolymphatic Hydrops Herniation Into the Semicircular Canals Detected on MRI.

Sugimoto S, Yoshida T, Teranishi M, Kobayashi M, Shimono M, Naganawa S, Sone M

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology Vol. 39 ( 10 ) page： 1229-1234 2018.10

Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer's Disease: A PET (THK5351, PiB) and Resting fMRI Study. Reviewed International journal Open Access

Takamasa Yokoi, Hirohisa Watanabe, Hiroshi Yamaguchi, Epifanio Bagarinao, Michihito Masuda, Kazunori Imai, Aya Ogura, Reiko Ohdake, Kazuya Kawabata, Kazuhiro Hara, Yuichi Riku, Shinsuke Ishigaki, Masahisa Katsuno, Shinichi Miyao, Katsuhiko Kato, Shinji Naganawa, Ryuichi Harada, Nobuyuki Okamura, Kazuhiko Yanai, Mari Yoshida, Gen Sobue

Frontiers in aging neuroscience Vol. 10 page： 304 - 304 2018.10

Language：English Publishing type：Research paper (scientific journal)

Background: Imaging studies in Alzheimer's disease (AD) have yet to answer the underlying questions concerning the relationship among tau retention, neuroinflammation, network disruption and cognitive decline. We compared the spatial retention patterns of 18F-THK5351 and resting state network (RSN) disruption in patients with early AD and healthy controls. Methods: We enrolled 23 11C-Pittsburgh compound B (PiB)-positive patients with early AD and 24 11C-PiB-negative participants as healthy controls. All participants underwent resting state functional MRI and 18F-THK5351 PET scans. We used scaled subprofile modeling/principal component analysis (SSM/PCA) to reduce the complexity of multivariate data and to identify patterns that exhibited the largest statistical effects (variances) in THK5351 concentration in AD and healthy controls. Findings: SSM/PCA identified a significant spatial THK5351 pattern composed by mainly three clusters including precuneus/posterior cingulate cortex (PCC), right and left dorsolateral prefrontal cortex (DLPFC) which accounted for 23.6% of the total subject voxel variance of the data and had 82.6% sensitivity and 79.1% specificity in discriminating AD from healthy controls. There was a significant relationship between the intensity of the 18F-THK5351 covariation pattern and cognitive scores in AD. The spatial patterns of 18F-THK5351 uptake showed significant similarity with intrinsic functional connectivity, especially in the PCC network. Seed-based connectivity analysis from the PCC showed significant decrease in connectivity over widespread brain regions in AD patients. An evaluation of an autopsied AD patient with Braak V showed that 18F-THK5351 retention corresponded to tau deposition, monoamine oxidase-B (MAO-B) and astrogliosis in the precuneus/PCC. Interpretation: We identified an AD-specific spatial pattern of 18F-THK5351 retention in the precuneus/PCC, an important connectivity hub region in the brain. Disruption of the functional connections of this important network hub may play an important role in developing dementia in AD.

DOI： 10.3389/fnagi.2018.00304

Open Access

Web of Science

PubMed

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Papers - NAGANAWA, Shinji