Faculty Profiles - NAGANAWA, Shinji

Papers - NAGANAWA, Shinji

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Gd-based Contrast Enhancement of the Perivascular Spaces in the Basal Ganglia Reviewed Open Access

Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka

MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 16 ( 1 ) page： 61 - 65 2017

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：JPN SOC MAGNETIC RESONANCE IN MEDICINE

Purpose: In textbooks, the perivascular space (PVS) is described as non-enhancing after the intravenous administration of gadolinium-based contrast agent (IV-GBCA). We noticed that the PVS sometimes has high signal intensity (SI) on heavily T-2-weighted 3D-FLAIR (hT(2)-FL) images obtained 4 h after IV-GBCA. The purpose of this study was to retrospectively evaluate the contrast enhancement of the PVS.
Materials and Methods: In 8 healthy subjects and 19 patients with suspected endolymphatic hydrops, magnetic resonance cisternography (MRC) and hT(2)-FL images were obtained before and 4 h after a single dose of IV-GBCA. No subjects had renal insufficiency. On axial MRC at the level of the anterior commissure (AC)-posterior commissure (PC) line, 1 cm circular regions of interest (ROIs) were drawn centering on the PVS in the bilateral basal ganglia and thalami. Three-millimeter diameter ROIs were set in the cerebrospinal fluid (CSF) of the bilateral ambient cistern. The ROIs on MRC were copied onto the hT2-FL images and the SI was measured. The SI ratio (SIR) was defined as SIRPVS = SI of PVS/SI of the thalami, and SIRCSF = SI of CSF/SI of the thalami. The average of the bilateral values was used for the calculation. The SIRCSF, SIRPVS, and SI of the thalami were compared between before and 4 h after IV-GBCA.
Results: The SIR was increased significantly from 1.02 +/- 0.37 to 2.65 +/- 0.82 in the CSF (P < 0.01) and from 1.20 +/- 0.35 to 2.13 +/- 1.23 in the PVS at 4 h after IV-GBCA (P < 0.01). The SI of the thalami showed no significant difference.
Conclusion: The enhancement of the PVS at 4 h after IV-GBCA was confirmed even in subjects without renal insufficiency. It is possible that the GBCA in the blood vessels might have permeated into the cerebrospinal fluid (CSF) space and the PVS. This might be a first step in the imaging evaluation of the glymphatic system (waste clearance system) of the brain.

DOI： 10.2463/mrms.mp.2016-0039

Open Access

Web of Science

PubMed

Quantitative evaluation of interstitial pneumonia using 3D-curved high-resolution CT imaging parallel to the chest wall: A pilot study. Reviewed International journal Open Access

Hiroyasu Umakoshi, Shingo Iwano, Tsutomu Inoue, Yuanzhong Li, Shinji Naganawa

PloS one Vol. 12 ( 9 ) page： e0185532 2017

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: To quantify the imaging findings of patients with interstitial pneumonia (IP) and emphysema using three-dimensional curved high-resolution computed tomography (3D-cHRCT) at a constant depth from the chest wall, and compare the results to visual assessment of IP and each patient's diffusing capacity of the lungs for carbon monoxide (DLco). METHODS: We retrospectively reviewed the axial CT findings and pulmonary function test results of 95 patients with lung cancer (72 men and 23 women, aged 45-84 years) with or without IP, as follows: non-IP (n = 47), mild IP (n = 31), and moderate IP (n = 17). The 3D-cHRCT images of the lung at a 1-cm depth from the chest wall were reconstructed automatically using original software; total area (TA), high-attenuation area (HAA) >-500 HU, and low-attenuation area (LAA) <-950 HU were calculated on a workstation. The %HAA and %LAA were calculated as follows: [Formula: see text], and [Formula: see text]. RESULTS: The %HAA and %LAA respective values were 3.2±0.9 and 27.7±8.2, 3.9±1.2 and 27.6±5.9, and 6.9±2.2 and 25.4±8.7 in non-IP, mild IP, and moderate IP patients, respectively. There were significant differences in %HAA between the 3 groups of patients (P<0.001), but no differences in %LAA (P = 0.558). Multiple linear regression analysis revealed that %HAA and %LAA were negatively correlated with predicted DLco (standard partial regression coefficient [b*] = -0.453, P<0.001; b* = -0.447, P<0.001, respectively). CONCLUSIONS: The %HAA and %LAA values computed using 3D-cHRCT were significantly correlated with DLco and may be important quantitative parameters for both IP and emphysema.

DOI： 10.1371/journal.pone.0185532

Open Access

Web of Science

PubMed

Detection of endolymphatic hydrops using traditional MR imaging sequences

Naganawa Shinji, Sone Michihiko

AMERICAN JOURNAL OF OTOLARYNGOLOGY Vol. 38 ( 5 ) page： 637-638 2017

CSF Pulsation Artifacts on ADC Maps Obtained with Readout-segmented EPI Open Access

Ohashi Toshio, Naganawa Shinji, Kanou Mai, Ikeda Mitsuru

MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 16 ( 2 ) page： 123-128 2017

A multicenter survey of stage T1 glottic cancer treated with radiotherapy delivered in 2.25-Gy fractions in clinical practice: An initial 5-year analysis. Open Access

Yoshiyuki Itoh, Seiji Kubota, Mariko Kawamura, Yoshihito Nomoto, Takayuki Murao, Kouji Yamakawa, Shunichi Ishihara, Naoki Hirasawa, Akiko Asano, Shigeo Yanagawa, Shinji Naganawa

Nagoya J. Med. Sci. Vol. 78 ( 4 ) page： 399-406 2016.12

Active brain changes after initiating fingolimod therapy in multiple sclerosis patients using individual voxel-based analyses for diffusion tensor imaging. Reviewed Open Access

Joe Senda, Hirohisa Watanabe, Kuniyuki Endo, Keizo Yasui, Yasuhiro Hawsegawa, Noritaka Yoneyama, Takashi Tsuboi, Kazuhiro Hara, Mizuki Ito, Naoki Atsuta, Bagarinao Epifanio Jr, Masahisa Katsuno, Shinji Naganawa, Gen Sobue

Nagoya J Med Sci. Vol. 78 ( 4 ) page： 455-463 2016.12

Magnetic resonance imaging of cardiac sarcoidosis: an evaluation of the cardiac segments and layers that exhibit late gadolinium enhancement. Reviewed Open Access

Tomohiro Komada, Kojiro Suzuki, Hiroaki Ishiguchi, Hisashi Kawai, Takahiro Okumura, Akihiro Hirashiki, Shinji Naganawa

Nagoya J. Med. Sci. Vol. 78 page： 437-446 2016.11

Involvement of the caudate nucleus head and its networks in sporadic amyotrophic lateral sclerosis-frontotemporal dementia continuum. Open Access

Michihito Masuda, Joe Senda, Hirohisa Watanabe, Bagarinao Epifanio, Yasuhiro Tanaka, Kazunori Imai, Yuchi Riku, Yuanzhe Li, Ryoichi Nakamura, Mizuki Ito, Shinsuke Ishigaki, Naoki Atsuta, Haruki Koike, Katsuno Masahisa, Nobutaka Hattori, Shinji Naganawa, Gen Sobue

Amyotroph Lateral Scler Frontotemporal Degener. Vol. 17 ( 7-8 ) page： 571-579 2016.10

Ⅳ ISMRMから読み解くMRI最新動向　1.臨床の視点から見たISMRM2016のトピックス―頭頸部領域を中心に

長縄慎二

INNERVISION Vol. 31 ( 9 ) page： 66-68 2016.9

Impact of Thin-Section Computed Tomography-Determined Combined Pulmonary Fibrosis and Emphysema on Outcomes Among Patients With Resected Lung Cancer Reviewed

Naozumi Hashimoto, Shingo Iwano, Koji Kawaguchi, Takayuki Fukui, Koichi Fukumoto, Shota Nakamura, Shunsuke Mori,Koji Sakamoto, Kenji Wakai, Kohei Yokoi, Yoshinori Hasegawa

Ann Thorac Surg. Vol. 102 ( 2 ) page： 440-447 2016.8

BOOK REVIEW：頭頸部の臨床画像診断学　改訂第3版

長縄慎二

画像診断 Vol. 36 ( 8 ) page： 799 2016.7

Diffusion tensor studies and voxel-based morphometry of the temporal lobe to determine the cognitive prognosis in cases of Alzheimer's disease and mild cognitive impairment: Do white matter changes precede gray matter changes?

Toshiaki Taoka, Fumihiko Yasuno, Masayuki Morikawa, Makoto Inoue, Kuniaki Kiuchi, Soichiro Kitamura, Kiwamu Matsuoka, Toshifumi Kishimoto, Kimihiko Kichikawa, Shinji Naganawa

SpringerPlus. Vol. 5 ( 1 ) page： 1023 2016.7

Evaluation of locoregional invasiveness of small-sized non-small cell lung cancers by enhanced dual-energy computed tomography. Reviewed Open Access

Hironori Shimamoto, Shingo Iwano, Hiroyasu Umakoshi, Koji Kawaguchi, Shinji Naganawa

Cancer Imaging. Vol. 16 ( 1 ) page： 18 2016.7

Characterization of stochastic noise and post-irradiation density growth for reflective-type radiochromic film in therapeutic photon beam dosimetry. Reviewed Open Access

Takeshi Kamomae, Masataka Oita, Naoki Hayashi, Motoharu Sasaki, Hideki Aoyama, Hiroshi Oguchi, Mariko Kawamura, Hajime Monzen, Yoshiyuki Itoh, Shiniji Naganawa

Phys Med Vol. 32 page： 1314-1320 2016.7

Late Rectal Toxicity from Image-guided Intensity Modulated Radiotherapy for Prostate Cancer.

Maki S, Itoh Y, Kubota S, Okada T, Nakahara R, Ito J, Kawamura M, Kamomae T, Naganawa S, Yoshino Y, Gotoh M, Ikeda M

Anticancer Res. Vol. 36 ( 6 ) page： 2967-2973 2016.6

Meniere's disease.

Tsutomu Nakashima, Ilmari Pyykko, Megan A. Arroll, Margaretha L. Casselbrant, Carol A. Foster, Nauman F. Manzoor, Cliff A. Megerian, Shinji Naganawa, Yi Ho Young

Nat Rev Dis Primers. 2016.5

Contrast-enhanced magnetic resonance pancreatography with gadoteridol by heavily T2-weighted three-dimensional fluid-attenuated inversion recovery: preliminary results in healthy subjects. Open Access

Kojiro Suzuki, Shinji Naganawa, Naohiro Furuhashi, Masahiro Yamazaki, Hiroshi Ogawa and Hisashi Kawai

Nagoya J. Med. Sci. Vol. 78 ( 2 ) page： 175-181 2016.5

Application of histogram analysis for the evaluation of vascular permeability in glioma by the K2 parameter obtained with the dynamic susceptibility contrast method: Comparisons with Ktrans obtained with the dynamic contrast enhance method and cerebral blood volume.

Toshiaki Taoka, Hisashi Kawai , Toshiki Nakane , Saeka Hori, Tomoko Ochi, Toshiteru Miyasaka, Masahiko Sakamoto, Kimihiko Kichikawa, Shinji Naganawa

Magn Reson Imaging. Vol. 34 ( 7 ) page： 896-901 2016.4

非正規分布拡散画像の評価方法の開発

田岡俊昭、長縄慎二、川井　恒

脳とこころの研究センター　脳疾患克服に向けた次世代創訳開発のためのコホート・コンソーシアム型研究拠点形成　平成27年度活動報告書 page： 32 2016.3

Comparison of the multidetector-row computed tomography findings of IgG4-related sclerosing cholangitis and extrahepatic cholangiocarcinoma.

Yata Masaki, Suzuki Kojiro, Furuhashi Naohiro, Kawakami K, Kawai Y, Naganawa Shinji

Clin Radiol. Vol. 71 ( 3 ) page： 203-210 2016.3

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Papers - NAGANAWA, Shinji