Faculty Profiles - NAGANAWA, Shinji

Papers - NAGANAWA, Shinji

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Clinical significance of endolymphatic imaging after intratympanic gadolinium injection

TSUTOMU NAKASHIMA, SHINJI NAGANAWA2, NAOMI KATAYAMA,MASAAKI TERANISHI, SEIICHI NAKATA, MAKOTO SUGIURA,MICHIHIKO SONE, SACHIO KASAI, MAYUMI YOSHIOKA& ASAKO YAMAMOTO

Acta Oto-Laryngologica Vol. 129 page： 9-14 2009

Grading of endolymphatic hydrops using magnetic resonance imaging

TSUTOMU NAKASHIMA, SHINJI NAGANAWA, ILMARI PYYKKO,WILLIAM P.R. GIBSON, MICHIHIKO SONE, SEIICHI NAKATA,MASAAKI TERANISHI

Acta Oto-Laryngologica Vol. 129 page： 5-8 2009

Diagnostic Whole-Body Scanning Before Radioiodine Therapy for Pulmonary Metastases of Diffrentiated Thyroid Cancer. Predictve Value and Recommendations.

Tachi Y, Iwano S, Kato K, Tadokoro M, Naganawa S

Clin Nucl Med Vol. 33 ( 12 ) page： 845-851 2008.12

Endovascular Management of Ruptured Pancreaticoduodenal Artery Aneurysms Associated with Celiac Axis Stenosis.

Suzuki K, Tachi Y, Ito S, Maruyama K, Mori Y, Komada T, Matsushima M, Ota T, Naganawa S

Cardiovasc Intervent Radiol Vol. 31 ( 6 ) page： 1082-7 2008.11

Language：English Publishing type：Research paper (scientific journal)

The purpose of this study was to assess the efficacy of transcatheter arterial embolization for ruptured pancreaticoduodenal artery (PDA) aneurysms associated with celiac axis stenosis (CS). Seven patients (four men and three women; mean age, 64; range, 43-84) were treated with transcatheter arterial embolization between 2002 and 2007. They were analyzed with regard to the clinical presentation, radiological finding, procedure, and outcome. All patients presented with sudden epigastric pain or abdominal discomfort. Contrast-enhanced CT showed a small aneurysm and retroperitoneal hematoma around the pancreatic head in all patients. The aneurysms ranged from 0.3 to 0.9 cm in size. In one patient, two aneurysms were detected. The aneurysms were located in the pancreaticoduodenal artery (n = 5) and the dorsal pancreatic artery (n = 3). Embolization was performed with microcoils in all aneurysms (n = 8). N-Butyl 2-cyanoacrylate (n = 1) and gelatine particle (n = 1) were also used. Complete occlusion was achieved in four patients. In the other three patients, a significantly reduced flow to the aneurysm remained at final angiography. However, these aneurysms were thrombosed on follow-up CT within 2 weeks. And there was no recurrence of the symptoms and bleeding during follow-up (mean, 28 months; range, 5-65 months) in all patients. In conclusion, transcatheter arterial embolization for PDA aneurysms associated with CS is effective. Significant reduction of the flow to the aneurysm at final angiography may be predictive of future thrombosis.

Arteriovenous malformation of the pancreas: assessment of clinical and multislice CT features.

Ogawa H, Itoh S, Mori Y, Suzuki K, Ota T, Naganawa S

Abdom Imaging. Vol. Epub ahead of print 2008.10

特集　地方会を考えるー地方会の意義；中部の場合ー

長縄慎二

Vol. 166 page： 8-9 2008.9

Three-Dimensional Fluid-Attenuated Inversion Recovery Magnetic Resonance Imaging Findings and Prognosis in Sudden Sensorineural Hearing Loss.

Yoshida T, Sugiura M, Naganawa S, Teranishi M, Nakata S, Nakashima T.

Laryngoscope Vol. 118 ( 8 ) page： 1433-7 2008.8

Imaging analysis in cases with inflammation-induced sensorineural hearing loss.

Sone Michiko, Mizuno Terukazu, Naganawa Shinji, Nakashima Tsutomu

Acta Otolaryngol Vol. 8 page： 1-5 2008.8

Focal inflammation in the embryological ventral pancreas: assessment using CT and MRI.

Itoh, S; Suzuki, K; Kawai, H; Naganawa, S

Clin Radiol Vol. 63 page： 433-441 2008.4

Cognitive impairments in multiple system atrophy: MSA-C vs MSA-P.

Kawai, Y; Suenaga, M; Takeda, A; Ito, M; Watanabe, H; Tanaka, F; Kato, K; Fukatsu, H; Naganawa, S; Kato, T; Ito, K; Sobue, G

Neurology Vol. 70 page： 1390-1396 2008.4

Language：English Publishing type：Research paper (scientific journal)

We evaluated comprehensive neuropsychological tests and regional brain blood flow to compare cognitive dysfunction between two types of multiple system atrophy: predominant cerebellar ataxia (MSA-C) and predominant parkinsonism (MSA-P). METHODS: Twenty-one patients with MSA-C, 14 patients with MSA-P, and 21 age- and education-matched control subjects were subjected to neuropsychological tests and SPECT. The neuropsychological tests examined general cognition, verbal and visual memory, working memory, visuospatial and constructional ability, language, executive function, depression, and anxiety, while SPECT analysis examined brain perfusion. RESULTS: Patients with MSA-P showed severe involvement of visuospatial and constructional function, verbal fluency, and executive function compared with control subjects. Patients with MSA-C showed involvement only in visuospatial and constructional function compared with control subjects and a milder degree of involvement compared with patients with MSA-P. Patients with MSA-P tended toward a wide and severe impairment in cognitive function compared with patients with MSA-C. In addition, neuropsychological impairment in patients with MSA-P was significantly correlated with a decrease in prefrontal perfusion. This significant relation was not correlated to other factors such as age, education, and severity of cerebellar ataxia and parkinsonism, which are relevant factors associated with cognitive performance. CONCLUSIONS: Patients with multiple system atrophy-parkinsonism show more severe and more widespread cognitive dysfunctions than patients with multiple system atrophy-cerebellar ataxia. Our results also indicate that cognitive dysfunction in patients with multiple system atrophy-parkinsonism may be associated with prefrontal involvement.

*Separate visualization of endolymphatic space, perilymphatic space and bone by a single pulse sequence; 3D-inversion recovery imaging utilizing real reconstruction after intratympanic Gd-DTPA administration at 3 Tesla.

Naganawa S, Satake H, Kawamura M, Fukatsu H, Sone M, Nakashima T

Eur Radiol Vol. 18 ( 5 ) page： 920-924 2008.3

*Imaging of Endolymphatic and Perilymphatic Fluid at 3T After Intratympanic Administration of Gadolinium-Diethylene-Triamine Pentaacetic Acid.

Naganawa S, Sugiura M, Kawamura M, Fukatsu H, Sone M, Nakashima T

AJNR Am J Neuroradiol Vol. 29 ( 4 ) page： 724-726 2008.1

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

SUMMARY: By optimizing the inversion time of a 3D inversion-recovery turbo spin-echo sequence at 3T, we obtained separate images of endolymphatic and perilymphatic space 24 hours after intratympanic administration of gadolinium contrast material. In patients with Meniere disease, endolymphatic hydrops were detected not only in the cochlea but also in the vestibule. Fusion of the 2 types of images visualized the entire fluid space of the labyrinth and the spatial relationship of the 2 spaces.

Arterial Spin Labeling(syngo ASL) Case Report from Nagoya University

Shinji Naganawa

MAGNETON Flash page： 26-33 2008.1

Neuroendocrine tumor in the breast.

Ogawa H, Nishio A, Satake H, Naganawa S, Imai T, Sawaki M, Yamamoto E, Miyata T.

Radiat Med Vol. 26 ( 1 ) page： 28-32 2008.1

Language：English Publishing type：Research paper (scientific journal)

A 34-year-old woman with a past history of a carcinoid tumor in the right ovary presented with a right breast mass found on contrast-enhanced computed tomography (CT) of the chest. She was asymptomatic, and her blood tests were normal. The mass measured about 2 cm. Mammography showed a lobular, circumscribed, high-density mass without microcalcifications in the upper outer quadrant of the right breast. Ultrasonography showed an irregular mass with both hypoechoic and hyperechoic components with increased vascularity. The mass was well enhanced on contrast-enhanced CT and dynamic magnetic resonance imaging. At the same time, a well-enhanced small nodule was detected in the pouch of Douglas. Both of the tumors were resected, and a primary breast neuroendocrine tumor (solid neuroendocrine carcinoma) and peritoneal dissemination of the ovarian carcinoid tumor were diagnosed.

Development and evaluation of a novel lossless image compression method (AIC: artificial intelligence compression method) using neural networks as artificial intelligence.

Fukatsu, Hiroshi; Naganawa, Shinji; Yumura, Shinnichiro

Radiat Med Vol. 26 page： 120-128 2008

内耳MRIの最前線

長縄慎二

臨床放射線 vol.53 No.11 Vol. 23 ( 11 ) page： 1324-1333 2008

Imaging endolymphatic hydrops at 3 tesla using 3D-FLAIR with intratympanic Gd-DTPA administration.

Naganawa, Shinji; Satake, Hiroko; Iwano, Shingo; Fukatsu, Hiroshi; Sone, Michihiko; Nakashima, Tsutomu

Magn Reson Med Sci Vol. 7 page： 85-91 2008

Intraductal papillary mucinous neoplasm of the pancreas: assessment of the likelihood of invasiveness with multisection CT.

Ogawa, Hiroshi; Itoh, Shigeki; Ikeda, Mitsuru; Suzuki, Kojiro; Naganawa, Shinji

Radiology Vol. 248 page： 876-886 2008

Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging investigation of inner ear disturbances in cases of middle ear cholesteatoma with labyrinthine fistula

Sone M, Mizuno T, Sugiura M, Naganawa S, Nakashima T.

Otol Neurotol. Vol. 28 ( 8 ) page： 1029-33 2007.12

Language：English Publishing type：Research paper (scientific journal)

To investigate the cause of inner ear disturbances in cases of middle ear cholesteatoma with labyrinthine fistula. SETTING: University hospital. STUDY DESIGN: Prospective case study. PATIENTS: Eight patients who were scheduled to undergo surgery for middle ear cholesteatoma with labyrinthine fistula were included in this study. INTERVENTION: Imaging analysis was performed using a 3-dimensional fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging sequence. MAIN OUTCOME MEASURES: Three-dimensional FLAIR findings were compared with clinical symptoms associated with inner ear disturbance and surgical observations of the fistula. RESULTS: Three-dimensional FLAIR in 6 patients revealed areas of high signal intensity in the inner ears on the affected sides and areas with increased signal after the administration of gadolinium, especially in cases accompanied by acute sensorineural hearing loss. These images were considered to be indicative of breakdown of the blood-labyrinth barrier due to middle ear cholesteatoma. This finding was also present in a patient with no clinical symptoms of inner ear disturbances. CONCLUSION: Three-dimensional FLAIR images of the inner ear are valuable in evaluating labyrinthine fistula in patients with cholesteatoma. Future studies are needed to better understand the role of 3-dimensional FLAIR in predicting the severity of inner ear disturbance.

Vestibular aqueduct in sudden sensorineural hearing loss

Sugiura M, Naganawa S, Ishida IM, Teranishi M, Nakata S, Yoshida T, Nakashima T

J Laryngol Otol Vol. 26 page： 1-6 2007.11

Language：English Publishing type：Research paper (scientific journal)

To evaluate the vestibular aqueduct in patients with sudden sensorineural hearing loss.Methods:We evaluated 19 patients (12 men and seven women; age range, 22-79 years) with unilateral sudden sensorineural hearing loss, using computed tomography and magnetic resonance imaging. All these patients had unilateral sudden sensorineural hearing loss. We also evaluated 47 control subjects (22 men and 25 women; age range, 22-79 years).Results:In sensorineural hearing loss affected ears, the width of the vestibular aqueduct at the midpoint and at the operculum was significantly greater than that in contralateral ears or in control ears. The width of the vestibular aqueduct at the midpoint and the operculum did not correlate with the audiometric threshold or the audiogram configuration. Contrast enhancement of the ipsilateral endolymphatic sac was observed in 17 of 19 patients with sudden sensorineural hearing loss (89 per cent). Eleven of these 17 patients also showed enhancement on the contralateral side, but no patient showed enhancement only on the contralateral side. In sensorineural hearing loss affected ears, the width of the vestibular aqueduct did not differ significantly between those patients with and without enhancement.Conclusions:The vestibular aqueducts of sudden sensorineural hearing loss affected ears are wider than those of controls. Precise imaging and evaluation of the inner ear is essential when investigating the pathological conditions responsible for sudden sensorineural hearing loss.

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Papers - NAGANAWA, Shinji